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7/26/2019 jurding hasya
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Oleh:
Hasyati Dwi Kinasih 1410221013
Pembimbing:
dr. Catur Banuai! "#. "
KEPANITERAAN KLINIK DEPARTEMEN SARAF
FAKULTAS KEDOKTERAN UPN “VETERAN” JAKARTAPeriode 23 Mei – 26 Juni 2!6
JOURNAL READING

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Latar Belakang
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e r e + r o - * / i n • M e n i n $ ' # & ' # n n e u r o $ e n e / i / d i $ * r u / d e n & # & e . i ) ) o , # % ) u /
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• R i # * # & ) e % + e r i # n ) e ) & i d e ) o r , i n e + r # i n

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finctional MagneticResonance Imaging r/1MRI

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• Di+eri'#n ! '#-i /e.#rido/i/ 3 %- dien,er'#nd#-#% /#-ine 9&o&#- in1u/! %-: IV
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Peni-#i#n
Ke#arahanstr'%e saat (0
0NI>SS
0 MRI un&u'%eni-#i -e/i##- d#&#diu+#. %en(#di'oordin#&&e%)-#&e o&#'%e%enu.i MNI
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0 r/1MRI

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D e / # i n
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A n # - i / i / ' e # % # n # n • S , r e e n i n $ d # & # # # - @ r i # * # & % e d i / - e n $ ' # ) 8 ) e % e r i ' / # # n 1 i / i ' 8 d # & #
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A n # - i / i / / & # & i / & i '
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An#-i/i/ ITT0LOF /u+'e-o%)o'
)#/ien den$#n $$n5 Mo&ori' +er#&
9n37 ,ere+ro-*/in2
)-#/e+o!7:
E1e' /i$ni1i'#n #n&#r#
#'&u d#n (eni/ in&er4en/i
FMA0T 9F38!2 <5B68 ) =
8: FMA0UL 9F38!2
3568 ) = 8:
Terd#)#& )er+ed##n
/i$ni1i'#n )#d# FMA0T
FMA0UL )#d# T2 T3
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d#/#r 9T: di 'e-o%)o' ere+ro-*/in 9r2
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5676:

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#n#-i/i/ /u+'e-o%)o' ITT0LOF )#/ien den$#n
$#n$$u#n %o&ori' /ed#n$
9n 2B ere+ro-*/in n !<8 )-#/e+o n ! GFMA0T di T G;<:
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An#-i/i/ di DTI
/u+'e-o%)o' ITT0
LOF )#/ien den$#n
$#n$$u#n %o&ori'
+er#& )#d# T
in&er#'/i /i$ni1i'#n #n&#r#
#'&u d#n (eni/ in&er4en/i
un&u' ADi)/i 9F28B 25;3!8 )
= 8: d#n RDi)/i 9F28B
35<B8 ) = 8:
#n#-i/i/ ITT0
LOF /u+'e-o%)o'
)#/ien $#n$$u#n %o&ori'
/ed#n$ )#d# T8 u(i ANOVA %enun(u''#n
in&er#'/i /i$ni1i'#n #n&#r#
#'&u d#n (eni/ in&er4en/i
)#d# DTI 9FAi)/i 8 ADi)/i
d#n RDi)/i:

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r/1MRI d#&# di#n#-i/i/ d#ri 2B )#/ien 9ere+ro-*/in
n !38 )-#/e+o n !6:
Peru+#.#n d#-#%
'one'/i/en/ori%o&or
)enin$'#&#n
/i%e&ri/ 'one'&i4i&#/
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ere+ro-*/in
u(i ANOVA +eru-#n$
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/i$ni1i'#n
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(eni/ in&er4en/i
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#n&#r# SM!/
+i-#&er#-
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)er+ed##n *#n$
/i$ni1i'#n d#-#%
)eru+#.#n LI T! d#n
T3

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Diskusi
> # / i - S & u d i • e r e + r o - * / i n / e - # % # 3 % i n $ $ u d i / & r o ' e 1 # / e / u + # ' u & ) e r + # i ' # n ) # d # 1 u n $ / i % o & o r i ' 3 + u - # n / e & e - # . o n / e & / & r o ' e H ' e - o % ) o ' ) - # / e + o
• P e n $ o + # & # n e r e + r o - * / i n / e - # % # 3 % i n $ $ u / e - # % # / & r o ' e 1 # / e / u + # ' u &
% e n u n ( u ' ' # n & i d # ' # d # e 1 e ' / # % ) i n $ / e r i u /

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S&udi )#d# .e#n %enun(u''#n 'e/#%##n d#-#% e'/)re/i $en
&er'#i& )-#/&i/i&#/ d#n &r#n/-#/i #n&#r# ##- )er'e%+#n$#n o&#'
d#n 1#/e /e%i#'u& /e&e-#. /&ro'e
"en ini d#n )ro&ein )en&in$ un&u' )er&u%+u.#n /#r#18
/*n#)&o$ene/i/ d#n )ro-i1er#/i /)ine dendri&i'5
D#-#% /&udi .e#n /&ro'e8 re.#+i-i&#/i %o&or0/en/ori' /e,#r#
/i$ni1i'#n %enin$'#& /##& )e%+eri#n ere+ro-*/in di%u-#i
d#-#% #'&u <; (#% /e&e-#. /&ro'e
Sed#n$'#n )#d# %#nu/i# di)er'ir#'#n indo )eriod un&u'
)e%u-i.#n ini #'#n -e+i. -#%# 9.#ri /d %in$$u:

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e1e' ere+ro-*/in )#d# )-#/&i/i&#/ 'one'/i %o&ori' den$#n DTI
d#n r/1MRI
An#-i/i/ ST0i/e DTI &e-#. %enun(u''#n /i$ni1i'#n/i in&er#'/i
un&u' RD d#n AD #n&#r# (eni/ in&er4en/i d#n #'&u )#d#
'e-o%)o' ,ere+ro-*/in
RD %enun(u''#n
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*#n$ %ere1-e'/i'#n #d#n*#
de%*e-in#/i
- )enurun#n AD
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Po&en/i ,ere+ro-*/in
&er.#d#) )er-indun$#n
de%*e-in#/i

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D#-#% )ene-i&i#n #-#u)un &id#' #d# in&er#'/i #n&#r# (eni/
in&er4en/i d#n #'&u di&un(u''#n un&u' FA
FA
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Ke-o%)o' ere+ro-*/in %enun(u''#n )e%u-i.#n 'one'&i4i&#/
1un$/ion#- /i%e&ri/ -e+i. +#i' )#d# 1un$/i %o&ori' 'or&i'#-

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Kelemahan penelitian
&id#' +i/# %en,#)#i &u(u#n u&#%#
%en$e4#-u#/i e1e'&i4i&#/ere+ro-*/in un&u' )e%u-i.#n %o&ori' diu'ur d#ri )enin$'#&#nFMA0T )#d# )#/ien den$#n $#n$$u#n %o&ori' /ed#n$ .in$$#+er#&
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#n*#' 1#'&or -#in d#-#% )e%u-i.#n %o&or )#d# )#/ien /&ro'e *#n$&id#' di /,reenin$ /e,#r# -en$'#)
S&udi -e+i. -#n(u& den$#n u'ur#n /#%)e- -e+i. +e/#r #'#n
di)er-u'#n un&u' %ene-##. %#/#-#. ini5

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Kesimpulan
Studi ini menunjukkan bahwapengobatan Cerebrolysin diatas
minggu dalam kombinasi dengan terapi
rehabilitasi di stroke !ase subakut amandan menyediakan e!ek menguntungkanpada pemulihan motorik pada pasien
dengan gangguan motorik berat