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6/6/2016 Vol 8, Issue 5, 2016
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ISSN: 0975–1491
Vol 8, Issue 5, 2016
TABLE OF CONTENTS
Review Article(s)
COFFEE: A HEALTH FUEL-BLOT POPULAR DRINKING 1-7
Torequl Islam, Marcus VinÍcius Oliveira Barros De Alenc, Guilherme Antonio Lopes DeOliveira, Ana Maria Oliveira Ferreira Da Mata, Samara Wanessa Cardoso Silva,MÁrcia Fernanda Correia Jardim Paz, Ana AmÉlia De Carvalho Melo-Cavalcante
Abstract || View PDF || View HTML || Download PDF [28 Downloads] 58 Views
A REVIEW ON BIOLOGICAL IMPORTANCE OF PYRIMIDINES IN THE NEW ERA 8-21
Meeta Sahu, Nadeem Siddiqui
Abstract || View PDF || View HTML || Download PDF [18 Downloads] 45 Views
THE PROSPECT, PROMISES AND HINDRANCES OF STATIN BASEMOLECULES: LOOK BACK TO LOOK FORWARD
22-33
Meor Mohd Affandi Mmr, Minaketan Tripathy, Aba Majeed
Abstract || View PDF || View HTML || Download PDF [11 Downloads] 21 Views
Original Article(s)
ISOLATION, SCREENING, AND CHARACTERIZATION OF CHITINASEPRODUCING BACTERIA FROM MARINE WASTES
34-36
S. Krithika, C. Chellaram
Abstract || View PDF || View HTML || Download PDF [23 Downloads] 175 Views
ANTIHYPERGLYCEMIC, ANTIOXIDANT, AND PANCREAS REGENERATIONACTIVITIES OF BLACK CUMIN (NIGELLA SATIVA L.) SEEDS ETHANOLEXTRACT IN ALLOXAN-INDUCED DIABETIC RATS
37-40
Gunawan P. Widodo, Rina Herowati, Jason M. Perangin-Angin, Jefri E.Y. Kamlasi
Abstract || View PDF || View HTML || Download PDF [19 Downloads] 87 Views
SERUM ANTI-ZONA PELLUCIDA ANTIBODIES IS CORRELATED WITHESTRADIOL LEVEL IN WOMEN WITH IN VITRO FERTILIZATION FAILURE
41-44
Hussein Kadhem Al-Hakeim, Iman Muhammed Jebur, Rafie Shakir Alkhafaji
Abstract || View PDF || View HTML || Download PDF [11 Downloads] 36 Views
DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FORSIMULTANEOUS ESTIMATION OF IMPURITIES FROM OLMESARTANMEDOXIMIL AND HYDROCHLOROTHIAZIDE TABLET
45-48
A. D. Mali, U. B. More, U. B. More
Abstract || View PDF || View HTML || Download PDF [16 Downloads] 50 Views
ANTI-NOCICEPTIVE AND ANTI-INFLAMMATORY PROPERTIES OF ESSENTIALOIL AND AQUEOUS EXTRACT OF ORMENIS MIXTA L. IN RODENTS
49-52
Ghizlane Hajjaj, Aziz Bahlouli, Mouna Tajani, Yahia Cherrah, Amina Zellou
Abstract || View PDF || View HTML || Download PDF [13 Downloads] 36 Views
ANTITUMOUR ACTIVITY OF MESO-ZEAXANTHINE AND ITS MECHANISM OFACTION
53-57
Home > Archives > Vol 8, Issue 5, 2016
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6/6/2016 Vol 8, Issue 5, 2016
http://innovareacademics.in/journals/index.php/ijpps/issue/view/Vol8Issue5 2/7
Firdous A. P., Binitha P. P, Girija Kuttan, Ramadasan Kuttan
Abstract || View PDF || View PDF || View HTML || Download PDF [8 Downloads] 58 Views
DRUG UTILIZATION STUDY OF ANTIHYPERGLYCEMIC AGENTS INOUTPATIENTS AT OPD CLINICS IN SOUTH INDIAN METROPOLITAN CITY
58-61
Kayamkani Abedulla Khan
Abstract || View PDF || View HTML || Download PDF [8 Downloads] 33 Views
AQUEOUS BARK EXTRACT OF TERMINALIA ARJUNA PROTECTS AGAINSTPHENYLHYDRAZINE INDUCED OXIDATIVE DAMAGE IN GOAT RED BLOODCELL MEMBRANE BOUND AND METABOLIC ENZYMES
62-70
Sudeshna Paul, Debosree Ghosh, Arnab Kumar Ghosh, Debajit Bhowmick, DebasishBandyopadhyay, Aindrila Chattopadhyay
Abstract || View PDF || View HTML || Download PDF [14 Downloads] 15 Views
IN SILICO PHARMACOKINETICS AND MOLECULAR DOCKING OF THREELEADS ISOLATED FROM TARCONANTHUS CAMPHORATUS L.
71-77
Amina I. Dirar, Ayman Y. Waddad, Magdi A. Mohamed, Malik S. Mohamed, Wadah J.Osman, Mona S. Mohammed, Mohamed A.A. Elbadawi, Sami Hamdoun
Abstract || View PDF || View HTML || Download PDF [5 Downloads] 105 Views
VIRTUAL SCREENING OF PHYTOCHEMICALS FOR METHOTREXATE LIKEDIHYDROFOLATE REDUCTASE AND AMINOIMIDAZOLE-4-CARBOXAMIDERIBONUCLEOTIDE (AICAR) TRANSFORMYLASE INHIBITORY PROPERTYUSING MOLEGRO VIRTUAL DOCKER
83-87
Devaprasad Markandeyan, Subramaniyan Kannaiyan, Sanmathi Suresh, RahulNimmakayala, Richard Ilamurugan, Kumaran Santhalingam, Benedict Paul
Abstract || View PDF || View HTML || Download PDF [3 Downloads] 52 Views
ANTIFERTILITY ACTIVITY OF Β-SITOSTEROL ISOLATED FROM BARLERIAPRIONITIS (L.) ROOTS IN MALE ALBINO RATS.
88-96
Kamini Singh, R. S. Gupta
Abstract || View PDF || View HTML || Download PDF [27 Downloads] 54 Views
ANXIOLYTIC ACTIVITY OF MARINE MACROALGAE SARGASSUM ILICIFOLIUMAND PADINA TETRASTOMATICA IN MICE
97-101
Subhash R. Yende, Uday N. Harle, Abhay M. Ittadwar
Abstract || View PDF || View HTML || Download PDF [7 Downloads] 28 Views
CHARACTERIZATION OF ANTIOXIDANT AND ANTIPROLIFERATIVE ACTIVITIESOF INDIAN SALMON (ELEUTHERONEMA TETRADACTYLUM) PROTEINHYDROLYSATES
102-108
Anahita Bakhshizadeh Gashti, H. S. Prakash
Abstract || View PDF || View HTML || Download PDF [8 Downloads] 28 Views
IN VITRO ANTIOXIDANT AND CYTOTOXIC ACTIVITY OF RUTIN AND PIPERINEAND THEIR SYNERGISTIC EFFECT
78-82
Prapurnachandra Yadala, A. H. M. Viswanathswamy
Abstract || View PDF || View HTML || Download PDF [11 Downloads] 31 Views
EFFECT OF TOLL-LIKE RECEPTOR INHIBITOR IMIQUIMOD ON IL1R1INTERACTION WITH IL-1RA AND ITS SNP VARIANT-AN IN SILICO APPROACH
109-112
Anand Thiyagaraj, Jithin S. Sunny, Waheeta Hopper
Abstract || View PDF || View HTML || Download PDF [6 Downloads] 53 Views
SYNTHESIS, CHARACTERIZATION AND PRELIMINARY ANTIMICROBIALEVALUATION OF NEW SCHIFF BASES OF AMPICILLIN AND AMOXICILLINDERIVED FROM ISATIN DERIVATIVES
113-116
May Mohammed Jawad Al-Mudhafar
Abstract || View PDF || View HTML || Download PDF [11 Downloads] 54 Views
ANTI-ARTHRITIC AND ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC LEAFEXTRACT OF ORMOCARPUM SENNOIDES
117-121
S. Srividya, G. Sridevi
Abstract || View PDF || View HTML || Download PDF [8 Downloads] 21 Views
EVALUATION OF DIURETIC AND ANTIUROLITHIATIC PROPERTIES OFETHANOLIC EXTRACT OF SIDA ACUTA BURM. F. IN WISTAR ALBINO RATS
122-126
Manu Mathew George, Shalini Adiga, Avin S., Amruta Tripathy
Abstract || View PDF || View HTML || Download PDF [5 Downloads] 19 Views
6/6/2016 Vol 8, Issue 5, 2016
http://innovareacademics.in/journals/index.php/ijpps/issue/view/Vol8Issue5 3/7
INVESTIGATION OF FORCED DEGRADATION PRODUCTS OF ETODOLAC BYLC AND LC-MS/MS
127-135
Divya Saxena, Shailesh Damale, Ajit Datar
Abstract || View PDF || View HTML || Download PDF [5 Downloads] 36 Views
NANOPRECIPITATION TECHNIQUE FOR PREPARATION OF STERICALLYSTABILIZED RISPERIDONE NANOSUSPENSION: IN VITRO AND IN VIVOSTUDY
136-142
Heba F. Salem, Rasha M. Kharshoum
Abstract || View PDF || View HTML || Download PDF [5 Downloads] 58 Views
DESIGN, IN-SILICO DOCKING AND PREDICTIVE ADME PROPERTIES OF SOMETHIAZOLIDINE-2, 4-DIONES DERIVATIVES AS PPARΓ MODULATORS
143-150
Sabina Yasmin, Venkatesan Jayaprakash
Abstract || View PDF || View HTML || Download PDF [7 Downloads] 67 Views
APPLICATION OF A VALIDATED STABILITY-INDICATING HPTLC METHOD FORSIMULTANEOUS QUANTITATIVE DETERMINATION OF CANDESARTANCILEXETIL AND HYDROCHLOROTHIAZIDE IN PHARMACEUTICAL DOSAGEFORM
151-157
Ambekar A. M., Kuchekar B. S.
Abstract || View PDF || View HTML || Download PDF [5 Downloads] 19 Views
HEPATOPROTECTIVE EFFECT OF PHYLLANTHUS NIRURI ALKALOIDFRACTION IN D–GALACTOSAMINE INDUCED HEPATITIS IN RATS
158-161
Bhasha Shanmugam, Kondeti Ramudu Shanmugam, Gangaraju Doraswamy, ShakuriRavi, Gangiginta Venkata Subbaiah, Kurakula Srinivas, Kesireddy Sathyavelu Reddy
Abstract || View PDF || View HTML || Download PDF [9 Downloads] 44 Views
EFFECTS OF N-NITROSODIBUTYLAMINE ON THE LIVER MITOCHONDRIAMORPHOLOGY AND ON THE EXPRESSION OF LIVER MITOCHONDRIALMEMBRANE SURFACE PROTEINS IN MICE.
162-168
Sthiti Porna Dutta, Robin Patnaik Jamir, Stephanie Paula Basaiawmoit, Anis Alam
Abstract || View PDF || View HTML || Download PDF [3 Downloads] 40 Views
FLOATING PULSATILE DRUG DELIVERY SYSTEM OF FAMOTIDINE: DESIGN,STATISTICAL OPTIMIZATION, AND IN VITRO EVALUATION
169-181
Madhusudhan Malladi, Raju Jukanti
Abstract || View PDF || View HTML || Download PDF [2 Downloads] 24 Views
GC-MS ANALYSIS AND EVALUATION OF BIOACTIVITIES OF KAEMPFERIAPARISHII - A NATURAL SOURCE OF TOTAROL
182-186
Suprava Sahoo, Sudipta Jena, Ambika Sahoo, Asit Ray, Noohi Nasim, Basudeba Kar,Sanghamitra Nayak
Abstract || View PDF || View HTML || Download PDF [3 Downloads] 57 Views
CYTOMORPHOLOGY OF SOME MEDICINAL GRASSES FROM HANGRANGVALLEY OF DISTRICT KINNAUR, HIMACHAL PRADESH
187-190
Kamlesh Kumari, Manjit Inder Singh Saggoo
Abstract || View PDF || View HTML || Download PDF [3 Downloads] 32 Views
ABSORPTION CORRECTION METHOD FOR THE SIMULTANEOUSESTIMATION OF N-ACETYL-L-CYSTEINE AND AMBROXOL HYDROCHLORIDEIN BULK AND IN COMBINED TABLET DOSAGE FORM
191-195
Vedang Kinjawadekar, Snehalatha Boddu, Deepali Jadhav, Sudha Rathod
Abstract || View PDF || View HTML || Download PDF [3 Downloads] 30 Views
SYNTHESIS OF MESOPOROUS SILICA NANOPARTICLES AND DRUGLOADING FOR GRAM POSITIVE AND GRAM NEGATIVE BACTERIA
196-201
S. Sharmiladevi, A. Shanmuga Priya, M. V. Sujitha
Abstract || View PDF || View HTML || Download PDF [6 Downloads] 19 Views
SCREENING OF SOME MEDICINAL PLANTS FOR THEIR ANTIMICROBIALACTIVITIES
202-206
Tilak Raj, Punit Kumar, Radha Rathee, Kashyap Kumar Dubey
Abstract || View PDF || View HTML || Download PDF [7 Downloads] 16 Views
ANTIFUNGAL ACTIVITY OF ENDOPHYTIC FUNGI ISOLATED FROM LANNEACOROMANDELICA – AN INSILICO APROACH
207-210
6/6/2016 Vol 8, Issue 5, 2016
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N. Premjanu, C. Jaynthy, S. Diviya
Abstract || View PDF || View HTML || Download PDF [13 Downloads] 23 Views
HISTONE ACETYLTRANSFERASE P300/CBP-ASSOCIATED FACTOR INHIBITIONBY QUERCETIN AS ANTICANCER DRUG CANDIDATE WITH IN SILICO AND INVITRO APPROACH
211-215
Rabiatul Adawiyah, Suryani ., I Made Artika
Abstract || View PDF || View HTML || Download PDF [2 Downloads] 13 Views
EXCIPIENTS COPROCESSING INFLUENCE ON THE INTERACTING VARIABLESTHAT AFFECT THE DISINTEGRATION PROPERTIES OF A PARACETAMOLTABLET FORMULATION
216-221
Abayomi Tolulope Ogunjimi, Gbenga Alebiowu
Abstract || View PDF || View HTML || Download PDF [5 Downloads] 6 Views
PHARMACOGNOSTICAL AND PHYTOCHEMICAL STUDIES OF PIPER BETLELINN.LEAF
222-226
Sapna Saini, Anju Dhiman, Sanju Nanda
Abstract || View PDF || View HTML || Download PDF [4 Downloads] 17 Views
ESSENTIAL OIL CONTENT AND CHEMICAL COMPOSITION OF EIGHT DILL(ANETHUM GRAVEOLENS L.) CULTIVARS CULTIVATED UNDER EGYPTIANCONDITIONS
227-231
Said-Al Ahl Hah, Omer Ea
Abstract || View PDF || View HTML || Download PDF [3 Downloads] 10 Views
DEVELOPMENT OF COSMOCEUTICAL PRODUCTS FROM NANO-SIZEDACTIVE COLOUR CONSTITUENTS OF RATANJOT, SEABUCKTHORN ANDANNATTO
232-237
Swati Pal, Sunita Malhotra, Satyanarayan Naik
Abstract || View PDF || View HTML || Download PDF [7 Downloads] 26 Views
FORMULATION AND EVALUATION OF ORAL SELF MICROEMULSIFYINGDRUG DELIVERY SYSTEM OF CANDESARTAN CILEXETIL
238-243
Jill Bhadresh Shukla
Abstract || View PDF || View HTML || Download PDF [3 Downloads] 30 Views
IMPACT ON PROLINE CONTENT OF JATROPHA CURCAS IN FLY ASHAMENDED SOIL WITH RESPECT TO HEAVY METALS
244-247
Seema Raj, Sumedha Mohan
Abstract || View PDF || View HTML || Download PDF [2 Downloads] 9 Views
PRENATAL DEVELOPMENTAL TOXICITY EVALUATION OF LOW MOLECULARWEIGHT GALACTOMANNANS BASED STANDARDIZED FENUGREEK SEEDEXTRACT DURING ORGANOGENESIS PERIOD OF PREGNANCY IN RATS
248-253
Pallavi Deshpande, Vishwaraman Mohan, Mukul Pore, Shailesh Gumaste, PrasadThakurdesai
Abstract || View PDF || View HTML || Download PDF [2 Downloads] 5 Views
CARDIO PROTECTIVE EFFECT OF TAMARINDUS INDICA. LINN AGAINSTISOPROTERENOL INDUCED MYOCARDIAL INFARCTION IN RATS
254-260
Nabeel Kinattingal, S. N. Manjula, K. Mruthunjaya, A. M. Mahalakshmi
Abstract || View PDF || View HTML || Download PDF [5 Downloads] 12 Views
PENTACYCLIC TRITERPENOIDS FROM THE STEM-BARK OF ALBIZIACHEVALIERI HAMS (MIMOSACEAE)
261-265
Mathias S. N., Abubakar M. S., October N.
Abstract || View PDF || View HTML || Download PDF [2 Downloads] 8 Views
EVALUATION OF STRESS ALLEVIATING POTENTIAL OF PERGULARIA DAEMIAON CERTAIN IMMUNOLOGICAL PARAMETERS
266-270
G. Sridevi, K. Sembulingam, Prema Sembulingam, Muhammed Ibrahim, S. Srividya
Abstract || View PDF || View HTML || Download PDF [3 Downloads] 8 Views
GLIMEPIRIDE FAST DISINTEGRATING TABLETS: FORMULATION,EVALUATION AND IN-VIVO DISINTEGRATION AND DYNAMIC STUDIES
271-278
Satheesh Jogala, Laxman Ankathi, Ramesh Naik Jarupula
Abstract || View PDF || View HTML || Download PDF [12 Downloads] 17 Views
DEVELOPMENT AND VALIDATION OF RP-HPLC AND UV
6/6/2016 Vol 8, Issue 5, 2016
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DEVELOPMENT AND VALIDATION OF RP-HPLC AND UVSPECTROPHOTOMETRIC METHODS FOR THE QUANTIFICATION OFCAPECITABINE
279-287
Sumanta Mondal, Reddy Narendra, Debjit Ghosh, Seru Ganapaty
Abstract || View PDF || View HTML || Download PDF [10 Downloads] 33 Views
ASSESSMENT OF PSYCHOLOGICAL STRESSORS OF DEPRESSION ANDANXIETY USING DEPRESSION ANXIETY STRESS SCALE-21 IN SOUTH INDIANHEALTHY VOLUNTEERS
288-295
Abhilash Thomas, Satendra K Dubey, Malay K. Samanta, Anu Alex, Sanesh P. Jose
Abstract || View HTML || View PDF || Download PDF [0 Downloads] 16 Views
EFFECT OF C-GLYCOSYL FLAVONE FROM URGINEA INDICA ON ANTIBIOTICINDUCED MICROBIAL CELL DEATH
296-305
Bevara Ganesh Babu, A.D. Naveen Kumar, Anil Badana, Seema Kumari, Anjali Jha, R.R. Malla
Abstract || View HTML || View PDF || Download PDF [0 Downloads] 21 Views
HPLC ASSAY OF MODEL TABLET FORMULATIONS CONTAININGMETRONIDAZOLE AND CIPROFLOXACIN
306-310
Vania Maslarska, Boyka Tsvetkova, Lily Peikova, Bistra Kostova, Dimitar Rachev,Stanislav Bozhanov, Nelina Zareva
Abstract || View PDF || View HTML || Download PDF [9 Downloads] 32 Views
EFFECT OF BIODEGRADABLE CO-POLYMERS AND DIVALENT CATIONS ONTHE SUSTAINED RELEASE ABILITY OF PROPRANOLOL HYDROCHLORIDELOADED BIOMATERIAL MICROSPHERES
311-317
Shahira F El-Menshawe, Rasha M. Kharshoum, Doaa S Hamad, Abdelkhalek Halawa
Abstract || View PDF || View HTML || Download PDF [2 Downloads] 12 Views
INFLUENCE OF PEG-4000 ON THE MICELLIZATION BEHAVIOR OF SDBS ANDCPC AT DIFFERENT TEMPERATURES
318-321
Vivek Sharma, Varsha Thakur, Ashish Kumar
Abstract || View PDF || View HTML || Download PDF [2 Downloads] 6 Views
LOADING OF CLARITHROMYCIN AND PACLITAXEL ON SYNTHESIZEDCDS/NIO NANOPARTICLES AS PROMISING NANOCARRIERS
322-333
Mustafa R. Abdulbaqi, Nidhal K. Maraie, Ashour H. Dawood
Abstract || View PDF || Download PDF [8 Downloads] 33 Views
UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OFTRAMADOL HYDROCHLORIDE AND ACECLOFENAC IN BULK AND TABLETDOSAGE FORM
334-340
Lydia Jeeboi, Snehalatha Boddu
Abstract || View PDF || View HTML || Download PDF [5 Downloads] 48 Views
RAPID SYNTHESIS OF SILVER NANOPARTICLES USING AQUEOUS LEAFEXTRACT OF ACHYRANTHES ASPERA AND STUDY OF THEIR ANTIMICROBIALAND FREE RADICAL SCAVENGING ACTIVITIES
341-346
Pushpalatha Bobbu, Vasudeva Reddy Netala, Aishwarya S., Indireddy Rama ManoharReddy, Venkata Subbaah Kotakadi, Vijaya Tartte
Abstract || View PDF || View HTML || Download PDF [5 Downloads] 24 Views
DEVELOPMENT OF SPECTROPHOTOMETRIC METHODS FOR THE ANALYSISOF FLORFENICOL IN BULK AND DOSAGE FORMS
347-349
Mohamed Elimam, Shaza Shantier, Elrasheed Gadkariem, Magdi Mohamed
Abstract || View PDF || View HTML || Download PDF [5 Downloads] 14 Views
MOLECULAR ANALYSIS OF GENE EXPRESSION RELATED TO THE EFFECTSOF DLBS3233 TREATMENT IN DIFFERENTIATION OF 3T3-L1 PRE-ADIPOCYTE
350-355
Rehmadanta Sitepu, Debbie Sofie Retnoningrum, Raymond R. TjandrawinataTjandrawinata
Abstract || View PDF || View HTML || Download PDF [4 Downloads] 22 Views
DEVELOPMENT AND EVALUATION OF OFLOXACIN FLOATING TABLETSUSING NATURAL POLYMER: STERCULIA FOETIDA LINN. GUM
356-360
Vijay D. Gulkari, Suparna S. Bakhle, Leena S. Yelane
Abstract || View PDF || View HTML || Download PDF [3 Downloads] 21 Views
DOCKING STUDIES ON BIOACTIVE COMPOUNDS OF NYCTANTHES ARBOR-
TRISTIS
361-365
6/6/2016 Vol 8, Issue 5, 2016
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TRISTIS
T. D. Sandhya Kumari, M. A Singara Charya
Abstract || View PDF || View HTML || Download PDF [3 Downloads] 11 Views
DEVELOPMENT AND VALIDATION OF A STABILITY-INDICATING RP-HPLCMETHOD FOR THE DETERMINATION OF XIPAMIDE IN PURE AND DOSAGEFORMS
366-371
Heba M. El-Sayed, Soad S. Abd El-Hay
Abstract || View PDF || View HTML || Download PDF [5 Downloads] 4 Views
PREVENTION OF OBESITY AND DEVELOPMENT OF METABOLIC SYNDROMEBY MANGOSTEEN (GARCINIA MANGOSTANA L.) PERICARP ETHANOLICEXTRACT IN MALE WISTAR RATS FED WITH HIGH-FAT DIET
372-378
Alkilany Salem Abuzaid, Elin Yulinah Iskandar, Neng Fisheri Kurniati, I Ketut Adnyana
Abstract || View PDF || View HTML || Download PDF [3 Downloads] 38 Views
EXTRACELLULAR ALKALINE PROTEASE PRODUCING HALO-ALKALITOLERANT BACTERIA ISOLATED FROM MARINE COASTS OF ODISHA
379-386
Abhas Kumar Maharana, Ishita Sinha, Prakash Chandra Behera, Pratima Ray
Abstract || View PDF || View HTML || Download PDF [2 Downloads] 36 Views
ANTIFUNGAL ACTIVITY OF NATURAL COLOURANT FROM MELIACOMPOSITA BARK AND ITS APPLICATION IN FUNCTIONAL TEXTILEFINISHING
387-391
Anita Pal, Rakesh Kumar, Y. C. Tripathi
Abstract || View PDF || View HTML || Download PDF [6 Downloads] 19 Views
CYTOTOXIC EFFECTS OF ALBIZIA ZYGIA (DC) J. F. MACBR, A GHANAIANMEDICINAL PLANT, AGAINST HUMAN T-LYMPHOBLAST-LIKE LEUKEMIA,PROSTATE AND BREAST CANCER CELL LINES
392-396
Regina Appiah-Opong, Isaac Kwadwo Asante, Dorcas Osei Safo, Isaac Tuffour,Ebenezer Ofori-Attah, Takuhiro Uto, Alexander Kwadwo Nyarko
Abstract || View PDF || View HTML || Download PDF [11 Downloads] 28 Views
Short Communication(s)
MORAXELLA OSLOENSIS MEDIATED SYNTHESIS OF TIO2 NANOPARTICLES 397-400
Valli Nachiyar C., Vijayalakshmi R., Nivedha Kumar, Bavanilatha M., Swetha Sunkar
Abstract || View PDF || View HTML || Download PDF [7 Downloads] 24 Views
THE ANALYSIS OF ANTIBIOTIC CONSUMPTION WITHIN THE TERTIARYHEALTHCARE INSTITUTION IN SERBIA DURING 10-YEAR PERIOD (2001-2010)
401-403
Jelena BrusiĆ- Renaud, Mirjana AntunoviĆ, Vesna ŠuljagiĆ
Abstract || View PDF || View HTML || Download PDF [4 Downloads] 15 Views
PHASE DEPENDENT DISCREPANCY IN MURINE VAGINAL MICRO-ENVIRONMENT: A CORRELATIVE ANALYSIS OF PH, GLYCOGEN AND SERUMESTROGEN UPON EXPOSURE TO LAPATINIB DITOSYLATE
404-407
Mahadevan Ganesan, Balamuthu Kadalmani
Abstract || View PDF || View HTML || Download PDF [4 Downloads] 10 Views
ANTIMICROBIAL ACTIVITY OF SYZYGIUM CALOPHYLLIFOLIUM WALP. LEAFEXTRACT
408-410
N Sumithra, Sevanan Rajesh Kumar
Abstract || View PDF || View HTML || Download PDF [6 Downloads] 9 Views
THE COMBINATION OF ROSELLA (HIBISCUS SABDARIFFA, L) AND STEVIA(STEVIA REBAUDIANA) EXTRACTS INCREASE THE ANTIOXIDANT ACTIVITYAND STABILITY
411-412
Nurkhasanah ., Dyah Nur Indah Minangsari, Vania Aniska Yulianny
Abstract || View PDF || View HTML || Download PDF [8 Downloads] 24 Views
PHYTOCHEMICAL SCREENING AND COMPARISON OF ANTIOXIDANTACTIVITY OF WATER AND ETHANOL EXTRACT PROPOLIS FROM MALAYSIA
413-415
Umar Zayyanu Usman, Ainul Bahiyah Abu Bakar, Mahaneem Mohamed
Abstract || View PDF || View HTML || Download PDF [6 Downloads] 83 Views
INTERACTION OF EBOLA VIRUS WITH INNATE AND ADAPTIVE IMMUNESYSTEM: AN IN SILICO STUDY
416-417
6/6/2016 Vol 8, Issue 5, 2016
http://innovareacademics.in/journals/index.php/ijpps/issue/view/Vol8Issue5 7/7
Open Access Policy || Publication Ethics
The publication is licensed under a Creative Commons License (CC BY) http://i.creativecommons.org/l/by/3.0/88x31.png. View Legal Code
Copyright © 2014 All Rights Reserved: Innovare Academic Sciences || Designed By: Anchal
SYSTEM: AN IN SILICO STUDY
Sony Jacob K.
Abstract || View PDF || View HTML || Download PDF [3 Downloads] 14 Views
ANTIDYSLIPIDEMIC ACTIVITY OF KATUK LEAVES SAPONINS FRACTION(SAUROPUS ANDROGYNUS (L.) MERR) IN RATS INDUCED WITH FAT-RICHDIET
418-420
Ni Kadek Warditiani, Milawati ., Ni Made Pitri Susanti
Abstract || View PDF || View HTML || Download PDF [4 Downloads] 18 Views
Case Study(s)
A RARE INSTANCE OF DIASTASE/PEPSIN – INDUCED HYPERSENSITIVITYREACTION
421-422
Navin Patil, Karthik Rao N, Handattu Manjunatha Hande, A Avinash, RaghavendraRao, Sushil Kiran Kunder, Anurag Pathak, Talha Ahmed
Abstract || View PDF || View HTML || Download PDF [4 Downloads] 2 Views
Erratum
WOUND HEALING ACTIVITY OF FRUITS OF ANAMIRTA COCCULUS LINN INRATS
423
V. Satya, M. Paridhavi
Abstract || Download PDF [4 Downloads] 3 Views
ANTI DYSLIPIDEMIC ACTIVITY OF KATUK LEAVES SAPONINS FRACTION (SAUROPUS ANDROGYNUS (L) MERR) IN RATS INDUCED WITH FAT-RICH DIET
Short Communication
NI KADEK WARDITIANI1, MILAWATI1, NI MADE PITRI SUSANTI1 1Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Udayana University, Bali, Indonesia 80361
Email: kadek.warditiani@gmail.com
Received: 30 Sep 2015 Revised and Accepted: 30 Mar 2016
ABSTRACT
Objective: The present study was to evaluate the anti dyslipidemic activity and the atherogenic indicator of saponin compound from katuk leaves (Sauropus androgynus (L).
Methods: This compound separated from Katuk leaves crude extract by column chromatography (a mobile phase: silica GF 254; mobile phase = gradient polarity of solvent (chloroform: methanol = 1:9-9:1). Male Wistar rats were fed with fat-rich diet (15% pig fats, 5% duck egg yolk) for 30 d to increase its total cholesterol level, triglyceride, LDL and to decrease blood HDL level compared to normal lipid level. Saponins fraction of Katuk leaves dose 10 and 30 mg/kg BW was given for 2 w and then its lipid level in blood was measured. Lipid level difference from each group was analyzed statistically.
Results: Total cholesterol, triglyceride, LDL and HDL level from a group of rats that were given saponins fraction of Katuk leaves was significantly different with negative control rats group and was not significantly different compared to normal control rats. Saponins fraction was able to reduce CRR, AR, and IAP value in treated rats.
Conclusion: Katuk leaves saponins fraction can become an anti dyslipidemic and also prevent the cardiovascular disorder in Wistar male rats.
Keywords: Dyslipidemia, Katuk leaves saponins fraction, Lipid profile
© 2016 The Authors. Published by Innovare Academic Sciences Pvt Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Increased low-density lipoprotein cholesterol (LDL-C) and decreased high-density lipoprotein cholesterol (HDL-C) are risk factors for cardiovascular diseases (CVD) [1]. Smaller LDL-C more easily oxidized compared LDL-C particles so small LDL-C are much more atherogenic [2]. HDL-C particles play a protective role against the development atherosclerosis [3]. The AIP (atherogenic index value accurately reflects the presence of atherogenic small LDL-C particles and HDL-C particles and it also a sensitive predictor of coronary atherosclerosis and cardiovascular risk [4].
In Indonesia, Katuk leaves (S. androgynus (L) Merr) were easily found. Based on the previous research, ethanol extract of Katuk leaves could have activity as antihyperlipidemic that decreasing total cholesterol, triglyceride, LDL-C and increasing HDL-C in the blood [5]. Katuk leaves contained secondary metabolites such as saponins, triterpene, polyphenol, flavonoid, and isoflavone. Yamamoto et al., stated that saponins, triterpene, and polyphenol had an activity of anti-obesity because it could block both pancreatic lipase enzyme in small intestine and absorption of triglyceride in the body [6]. Han et al., also stated that the saponins contained in tea leaves could block the pancreatic lipase enzyme so it could decrease body weight and adipose tissue in rabbits fed with fat-rich diet [7]. Saponins fraction of Ilex paraguariensis at dose 1.75±0.2 mg/day/animal could induced lipogenesis in muscle and adipose tissue [8]. The aim of this work is to assess the effects of saponin fraction of Katuk leaves on decreasing total cholesterol, triglyceride, LDL-C, and increasing HDL-C and calculate atherosclerosis index value in rats induced with fat-rich diet.
Katuk leaves (S. androgynus (L) Merr.) obtained from the local area of Girimulyo village, Nanggulan area, Kulonprogo regency, Yogyakarta, Indonesia. This plant was identified and authenticated by a botanist at the Pharmaceutical Biology Laboratory, Faculty of Pharmacy, Gadjah Mada University, Indonesia.
Katuk leaves powder was defatted with n-hexane and the n-hexane insoluble part was macerated. The ethanol soluble part was separated, and its solvent was evaporated. Fractionation was conducted with column chromatography, the solvent ratio of
chloroform: methanol 9:1 until 1:9 for 20 ml. Each 5 ml of the fraction was stored.
Saponins identification was conducted with foam height test; some fraction was mixed with water and shaken vigorously. It would form the persistent appearance of foam with 1-10 cm height and when added with HCl 2N, the foam would still present [9].
Wistar male albino rats, aged 4 w, 150-200 g of weight were used for the antidyslipimic study. The rats were maintained under controlled condition, were used in the experiment. The rats were fed with standard chow diet and given drink ad libitum. Ethical Clearance of the animal’s handling was provided by the Faculty of Veterinary, Udayana University no: 189/KE-PH-Lit-1/V/2015. Environment condition adaptation for animals was conducted for 1 w. Animals were then grouped as following:
- Normal group: rats were fed with normal diet.
- Negative control group: rats were fed with fat-rich diet.
- Positive control group: rats were fed with fat-rich diet and treated with 1.8 mg/kg BW simvastatin [10].
- Saponins fraction group 1: rats were fed with fat-rich diet and treated with Katuk leaves saponins fraction with 10 mg/kg BW.
- Saponins fraction group 2: rats were fed with fat-rich diet and treated with Katuk leaves saponins fraction with 30 mg/kg BW.
After environment adaptation, dyslipidemia induction was done by giving fat-rich diet (15% lard, 10% yolk) for 30 d and blood lipid level was then measured [11]. After blood lipid level measurement, treated rats were given Katuk leaves saponins fraction and simvastatin in treatment groups for 2 w. Katuk leaves saponins fraction was given at doses 10 and 30 mg/kg BW, its higher than saponins fraction of Ilex paraguariensis doses 1.75±0.2 mg/day/animal [8].
Total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL) measured with standard reagent (DiaSys, Holzeim, Germany).
International Journal of Pharmacy and Pharmaceutical Sciences
ISSN- 0975-1491 Vol 8, Issue 5, 2016
Warditiani et al.
Int J Pharm Pharm Sci, Vol 8, Issue 5, 418-420
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The atherogenic indices were calculated as follows: [12]
Cardiac Risk Ratio (CRR) = TG/HDL
Atherogenic Coefficient (AC) = (TG-HDL)/HDL
Atherogenic Index of Plasma (AIP) = log (TG/HDL)
The obtained data was absorbance data. The obtained absorbance value was changed into blood lipid level (mg/dL). Blood lipid level data homogeneity and normality from all animal groups were analyzed and then Mann-Whitney test was used.
Column chromatography was used to saponin separation compound from a crude extract of Katuk leaves. We use combination solvent chloroform and methanol (9:1 until 1:9 each 10 ml). The fraction was collect each 5 ml. The fraction obtained until 20 fractions. TLC staning with H2SO4 spray and H2SO4. vanilline used to detect the content of terpenoid compound in each fraction. The result shown that fraction number 11 until 20 contained terpenoid compound. Foaming test of the fraction was used to detect the content of saponin compound. fraction no 15-17 was positive formed foam.
Based on rat’s blood lipid measurement, it was known that the treated animals fed with fat-rich diet for 6 w had an elevation of total cholesterol level, LDL and triglyceride and reduction of HDL compared to normal control group (fig. 1). There was a significant lipid profile difference between groups fed with fat-rich diet (negative control, positive control, 10 and 30 mg/kg BW saponins fraction group) towards the normal control group (p<0.05). Dyslipidemia condition characterized by hypercholesterolemia and hypertriglyceridemia is a most prevalent indicator of cardiovascular diseases [13].
Fig. 1: Alteration graph of blood TC (total cholesterol), TG (triglyceride), LDL and HDL after fat-rich diet (n=5; mean±SD). *
signs show that there are significant difference with normal control group (p<0.05)
TC = blood total cholesterol level; TG= blood triglyceride level; LDL= blood LDL level; HDL= blood HDL level; = normal
control; = negative control; = 1.8 mg/kg BW simvastatin group; = 10 mg/kg BW saponins fraction group; = 30 mg/kg
BW saponins fraction group
Treatments (simvastatin, 10 and 30 mg/kg BW saponins fraction) were conducted for 3 w. Blood measurement of rats show that
saponins fraction and simvastatin could decrease TC, TG, and LDL and increase blood HDL level (fig. 2). There was a significant lipid profile difference between treatment groups (simvastatin, 10 and 30 mg/kg BW saponins fraction) towards negative control group. Increased level of LDL-C and triglyceride in serum is a risk factor for cardiovascular disease [14]. The antidyslipidemic activity of saponins fraction is not significantly different with positive control group ability (simvastatin). Saponins have the ability in block pancreatic lipase enzyme so that cholesterol absorption in the intestine will decrease [15, 16]. Saponins of sea cucumber can decreased lipids by enhancing β-oxidation via activating PPARα [8]. Saponins fraction of Ilex paraguariensis at dose 1.75±0.2 mg/day/animal were able to influence the lipid metabolism of male Wistar rats fed with a high-fat diet by induce lipogenesis in muscle and adipose tissue. It’s also could induced a 40% increase fecal fat excretion. These results may be correlated with saponins ability to inhibited pancreatic lipase enzyme [8].
Fig. 2: Alteration graph of blood TC (total cholesterol), TG (triglyceride), LDL and HDL treatment (n=5; mean±SD). * signs show that there are significant difference with negative control
group (p<0.05) TC = blood total cholesterol level; TG= blood triglyceride level;
LDL= blood LDL level; HDL= blood HDL level; = normal control; = negative control; = 1.8 mg/kg BW simvastatin
group; = 10 mg/kg BW saponins fraction group; = 30 mg/kg BW saponins fraction group
Atherogenic is an indicator that shows cardiovascular disorder. The higher the value, the risk of cardiovascular disorder will increase [17-19]. In this research, saponin fraction could decrease atherogenic indicators such as CRR, AC and AIP (table 1) according to Ikewuchi and Ikewuchi [11]. There was an elevated ratio of TG: HDL (CRR) in treated rats fed with fat-rich diet for 6 w and this indicates risk of cardiovascular disorder. There were significant difference of CRR, AC and AIP value between normal control group and other groups (p<0,05). Saponin fraction could reduce TG level and increase HDL level in blood and it made the CRR value decrease. Atherogenic index is a powerful indicator of heart disease risk. The ability of saponin to decrease atherogenic index can be used as one way to prevent cardiovascular disorder due to its ability as anti dyslipidemic agent. All of results show the indication of protective mechanism of saponin fraction of Sauropus androgynus (L) merr. against the development of atherosclerosis as well as the dyslipidemia condition.
Table 1: Atherogenic index alteration before and after treatment in rats
Groups CRR AC AIP Before After Before After Before After
Normal control 9.1602 5.4049 8.1602 4.4049 0.9604 0.7318 Negative control 22.8104* 59.6515 21.8104* 58.6515 1.3577* 1.7401 Positive control 19.8102* 2.0327+ 18.8102* 1.0327+ 1.2949* 0.2989+ Saponins 10 mg/kg BW 22.8528* 1.9322+ 21.8528* 0.9322+ 1.3582* 0.2729+ Saponins 30 mg/kg BW 19.3786* 4.4372+ 18.3786* 3.4372+ 1.2790* 0.6365+
CRR = Cardiac Risk Ratio; AC = Atherogenic Coefficient; AIP = Atherogenic Index of Plasma; * significantly different with normal control group (p<0.05);+significantly different with before treatment (p<0.05), Katuk leaves saponins fraction (Sauropus androgynus (L) merr.) can reduce TC, TG and LDL level and elevate HDL level in blood. Saponins fraction also able to decrease atherogenic indicators (CRR, AC and AIP) so that it can prevent cardiovascular disorder.
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ACKNOWLEDGEMENT
We gratefully thank to Universitas Udayana Bali Indonesia through Research Grand Dosen Muda 2014.
CONFLICTS OF INTERESTS
All authors have none to declare
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ANTI DYSLIPIDEMIC ACTIVITYOF KATUK LEAVES
SAPONINS FRACTION(SAUROPUS ANDROGYNUS(L) MERR) IN RATS INDUCED
WITH FAT-RICH DIETby Kadek Warditiani
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ANTI DYSLIPIDEMIC ACTIVITY OF KATUK LEAVESSAPONINS FRACTION (SAUROPUS ANDROGYNUS (L)MERR) IN RATS INDUCED WITH FAT-RICH DIETORIGINALITY REPORT
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