Geriatrics and Gerontology

GerontologyInternational Journal of Experimental, Clinical, Behavioral and Technological Gerontology

Karger

66 | 05 | 20Gerontology |

The importance of vaccines for the older population

Many infectious diseases are more frequent and are associ-ated with high morbidity and mortality in older adults. Vac-cination is the most efficient strategy to prevent infections, and older adults are an important target population for vaccination in order to promote health in this age group. Age-related changes in the immune system as well as other factors, such as comorbidities, obesity or frailty, influ-ence vaccine-induced immune responses in old age. Awareness that vaccines developed for children might not be optimal for adults, and particularly for the older popula-tion, has only arisen in the recent past. Vaccination against influenza, pneumococcal disease, and herpes zoster is spe-cifically recommended for older adults in many countries, and various strategies have been pursued in order to opti-mize these vaccines. However, there are still many patho-gens, which severely affect the older population, but for which no vaccines are currently available. Extensive re-search and development are ongoing to further improve existing vaccines and to design novel vaccines in order to provide protection for this vulnerable age group. In order to exploit the full protective potential of vaccines it is es-sential to improve vaccine uptake and overcome vaccine hesitancy by providing information and education to stake-holders, health care professionals, and the general public.

This book is relevant for researchers working on age-related changes in the immune system or on vaccine development, for health care professionals treating older patients, and for the stakeholders and decision makers involved in vaccina-tion recommendations and implementation.

Contents

• Preliminaries: Weinberger, B. (Innsbruck)• Preface: Weinberger, B. (Innsbruck)

Immunosenescence and Other Risk Factors AffectingVaccination Success in Old Age• How Inflammation Blunts Innate Immunity in Aging:

Goldberg, E.L.; Shaw, A.C.; Montgomery, R.R. (New Haven, CT)

• Natural Killer Cells, Aging, and Vaccination: Witkowski, J.M. (Gdansk); Larbi, A. (Singapore/Tunis); Le Page, A.; Fülöp, T. (Sherbrooke, QC)

• Changes in T Cell Homeostasis and Vaccine Responses in Old Age: Wong, G.C.L. (Singapore); Strickland, M.C. (Singapore/Southhampton); Larbi, A. (Singapore/Sherbrooke, QC/Tunis)

• Age-Related Changes in B Cells Relevant to Vaccine Responses: Dunn-Walters, D.; Stewart, A.; Sinclair, E.; Serangeli, I. (Guildford)

• Comorbidities in the Elderly and Their Possible Influence on Vaccine Response: Kwetkat, A. (Jena); Heppner, H.J. (Witten/Schwelm)

• The Impact of Obesity and Metabolic Syndrome on Vaccination Success: Frasca, D.; Blomberg, B.B. (Miami, FL)

Current Vaccines for the Older Population• Influenza Vaccination: Accelerating the Process for New

Vaccine Development in Older Adults: McElhaney, J.E. (Sudbury, ON); Andrew, M.K. (Halifax, NS); Haynes, L.; Kuchel, G.A. (Farmington, CT); McNeil, S.A. (Halifax, NS); Pawelec, G. (Sudbury, ON/Tübingen)

• Vaccines to Protect Older Adults against Pneumococcal Disease: van de Garde, M.D.B.; Knol, M.J.; Rots, N.Y.; van Baarle, D.; van Els, C.A.C.M. (Bilthoven)

• Herpes Zoster and Its Prevention by Vaccination:Johnson, R.W. (Bristol); Levin, M.J. (Aurora, CO)

• Vaccination of Adults and the Older Population against Tetanus, Diphtheria, Pertussis, and Tick-Borne Encephalitis:The Importance of Booster Vaccinations throughout Life:Weinberger, B. (Innsbruck)

• Vaccines for Older Travelers: Jilg, W. (Regensburg)

The Future of Vaccines for the Older Population• Vaccination against Respiratory Syncytial Virus:

Green, C.A. (Oxford); Drysdale, S.B. (Oxford/London); Pollard, A.J. (Oxford); Sande, C.J. (Oxford/Kilifi)

• Vaccination Against Nosocomial Infections in Elderly Adults:Anderson, A.S.; Scully, I.L.; Pride, M.W.; Jansen, K.U. (Pearl River, NY)

• Novel Technologies to Improve Vaccines for Older Adults:Laupèze, B.; van der Most, R. (Wavre); Del Giudice, G. (Siena)

• Strategies to Improve Vaccine Uptake throughout Adulthood: Ecarnot, F. (Besançon); Maggi, S. (Padua); Michel, J.-P. (Geneva)

Author Index / Subject Index

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Vaccines for Older Adults: Current Practices and Future OpportunitiesEditor Birgit Weinberger

Vaccines for Older Adults: Current Practices and Future OpportunitiesEditor: Weinberger, B. (Innsbruck)X + 254 p., 17 fig., 9 in color, 11 tab., 2020CHF 123.00 / EUR 115.00 / USD 145.00 Hard cover or online prices for personal customersPrices subject to change, VAT not included EUR price for eurozone countries, USD price for USA and Latin America onlyISBN 978–3–318–06677–7e-ISBN 978–3–318–06678–4

Interdisciplinary Topics in Gerontology and Geriatrics, Vol. 43Series Editor: Fülöp, T. (Sherbrooke, QC)ISSN 2297–3508 / e-ISSN 2297–3486

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Interdisciplinary Topics inGerontology and Geriatrics

Editor: T. Fulop

Vol. 43

Vaccines for Older Adults: Current Practices and Future Opportunities

Editor

B. Weinberger

Printed in Germany on acid-free and non-aging paper (ISO 9706) by Stückle Druck, Ettenheim

International Journal of Experimental, Clinical, Behavioral, Regenerative and Technological Gerontology

Founded 1957 by F. Verzár as “Gerontologia”Merged 1975 with “Gerontologia Clinica”, founded 1959 by E. Woodford-Williams and

A.N. Exton-SmithContinued by F. Bourlière (1971–1983), H.P. von Hahn (1984–1990), M. Ermini (1991–1994),

W. Meier-Ruge (1995–2007), G. Wick (2008–2019)

Organ of the International Association of Gerontology and Geriatrics (IAGG)

Editor-in-Chief

Tamas Fülöp – University of Sherbrooke, Sherbrooke, QC, Canada

Managing Editor

G. Lepperdinger – Salzburg

Section Editors

Clinical SectionChristophe J. Büla – University of Lausanne Medical Center, Lausanne, SwitzerlandMonika Lechleitner – A.ö. Landeskrankenhaus Hochzirl, Zirl, AustriaPeter Pietschmann – Medical University of Vienna, Vienna, Austria

Experimental SectionAndrzej Bartke – Southern Illinois University School of Medicine, Springfield, IL, USABjörn Schumacher – University of Cologne, Cologne, GermanyNektarios Tavernarakis – University of Crete, Heraklion, GreeceJan Vijg – Albert Einstein College of Medicine, Bronx, NY, USA

Behavioral Science SectionDenis Gerstorf – Humboldt-University, Berlin, GermanyJulie D. Henry – University of Queensland, St. Lucia, QLD, AustraliaThomas M. Hess – North Carolina State University, Raleigh, NC, USATim Windsor – Flinders University, Adelaide, SA, Australia

Regenerative SectionDavid M. Gardiner – University of California at Irvine, Irvine, CA, USAGünter Lepperdinger – Universität Salzburg, Salzburg, Austria

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Gerontology

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Technological SectionBijan Najafi – Baylor College of Medicine, Houston, TX, USAMichael Schwenk – Universität Heidelberg, Heidelberg, Germany

Editorial Board

Clinical SectionJohannes Attems – Newcastle University, Newcastle upon Tyne, UKMichael D. Beach – University of Pittsburgh School of Nursing, Pittsburgh, PA, USAJoel Belmin – Sorbonne University, Paris, FranceMartin Burtscher – Universität Innsbruck, Innsbruck, AustriaGiuseppe Del Giudice – Novartis Vaccines and Diagnostics, Siena, ItalyVincent C. Emery – University of Senate, Guildford, UKJorge D. Erusalimsky – University of Wales, Cardiff, UKTimothy W. Farrell – University of Utah, Salt Lake City, UT, USALuigi Fontana – The University of Sydney, Sydney, NSW, AustraliaM. Eric Gershwin – University of California at Davis, Davis, CA, USAJorg Goronzy – Stanford University School of Medicine, Stanford, CA, USAUrs Granacher – University of Postdam, Potsdam, GermanyStefan Gravenstein – Brown University, Providence, RI, USAErin R. Hascup – SIU School of Medicine, Springfield, IL, USAKlaus Hauer – Bethanien Krankenhaus, Heidelberg, GermanyDae Hyun Kim – Harvard Medical School, Boston, MA, USAFlorian Kronenberg – Medizinische Universität Innsbruck, Innsbruck, AustriaTom F. Lue – University of California at San Francisco, San Francisco, CA, USAAndrea B. Maier – The University of Melbourne, Melbourne, VIC, AustraliaS. Jay Olshansky – University of Illinois at Chicago, Chicago, IL, USAMarwan N. Sabbagh – Cleveland Clinic, Las Vegas, NV, USARené Schwendimann – Universität Basel, Basel, SwitzerlandKlaus Seppi – Medizinische Universität Innsruck, Innsbruck, AustriaThomas M. Stulnig – Medical University of Vienna, Vienna, AustriaDonald Craig Willcox – Okinawa International University, Ginowan, Japan

Experimental SectionAi-Min Bao – Zhejiang University, Hangzhou, ChinaHolly M. Brown-Borg – University of North Dakota, Grand Forks, ND, USACollin Y. Ewald – ETH Zurich, Zurich, SwitzerlandBjörn Falkenburger – University Medical Centre Carl Gustav Carus, Dresden, GermanyDaniela Frasca – University of Miami, Miami, FL, USALeonid Gavrilov – NORC and the University of Chicago, Chicago, IL, USAEfstathios S. Gonos – National Hellenic Research Foundation, Athens, GreeceMarcia C. Haigis – Harvard Medical School, Boston, MA, USALaura Haynes – University of Connecticut Health Center, Farmington, CT, USA

(Continued)

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Susan E. Howlett – Dalhousie University, Halifax, NS, CanadaS. Michal Jazwinski – Tulane Center for Aging, New Orleans, LA, USAGuido Kroemer – Inserm U848, Villejuif, FranceAntonello Lorenzini – University of Bologna, Bologna, ItalyArnold Mitnitski – Dalhousie University, Halifax, NS, CanadaAlexey Moskalev – Komi Science Center of RAS, Syktyvkar, Russian FederationJanko Nikolich-Zugich – University of Arizona College of Medicine, Tucson, AZ, USAWilson Savino – Oswaldo Cruz Institute, Rio de Janeiro, BrazilYaron Tomer – Albert Einstein College of Medicine, Bronx, NY, USANatascia Ventura – Heinrich Heine University, Düsseldorf, GermanyAndrus Viidik – Aarhus, DenmarkGeorg Wick – Innsbruck Medical University, Biocenter,

Division for Experimental Pathology and Immunology, Innsbruck, AustriaJacek M. Witkowski – Medical University of Gdańsk, Gdańsk, PolandJohannes Zuber – Institute of Molecular Pathology, Vienna, Austria

Behavioral Science SectionKaarin J. Anstey – University of New South Wales, Sydney, NSW, AustraliaKira S. Birditt – University of Michigan, Ann Arbor, MI, USALinda Clare – University of Exeter, Exeter, UKDale Dannefer – Case Western Reserve University, Cleveland, OH, USAXin-Qi Dong – Rutgers University, New Brunswick, NJ, USAKatherine L. Fiori – Adelphi University, Garden City, NY, USAAlan J. Gow – Heriot-Watt University, Edinburgh, UKDaniel Grühn – North Carolina State University, Raleigh, NC, USADenise Park – University of Texas at Dallas Center for Brain Health, Dallas, TX, USAChristina Röcke – University of Zurich, Zurich, SwitzerlandBrent J. Small – University of South Florida, Tampa, FL, USA

Regenerative SectionJames Adjaye – Heinrich Heine University, Düsseldorf, GermanyIlaria Bellantuono – The University of Sheffield, Sheffield, UKUmberto Galderisi – Università della Campania “Luigi Vanvitelli”, Naples, ItalyJohannes Grillari – University of Natural Resources and Life Sciences, Vienna, AustriaHeinrich Jasper – Genentech, Inc., South San Francisco, CA, USAKyung-Sun Kang – Seoul National University, Seoul, Republic of KoreaArmand Keating – Princess Margaret Hospital, Toronto, ON, CanadaJames R. Mitchell – Harvard University, Boston, MA, USAPatrick Vermette – University of Sherbrooke, Sherbrooke, QC, CanadaQingbo Xu – King’s College London, London, UK

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Technological SectionSumi Helal – Lancaster University, Lancaster, UKJorunn L. Helbostad – Norwegian University of Science and Technology, Trondheim,

NorwayHylton B. Menz – La Trobe University, Bundoora, VIC, AustraliaPrudence Plummer – MGH Institute of Health Professions, Boston, MA, USANeil D. Reeves – Manchester Metropolitan University, Manchester, UKWolfgang Zagler – Vienna, Austria

Statistical ConsultantChristopher Ryne Estabrook – University of Illinois at Chicago, Chicago, IL, USA

Editor for the IAGG

Monica Rodriguez Perracini – City University of Sao Paulo, Sao Paulo, Brazil

(Continued)

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Journal Information

Aims and ScopeIn view of the ever-increasing fraction of elderly people, understanding the mechanisms of aging and age-related diseases has become a matter of urgent necessity. Gerontology, the oldest journal in the field, is also the only journal that responds to this need by drawing topical contributions from multiple disciplines to support the fundamental goals of extend-ing active life and enhancing its quality. The range of papers is classified into five sections. In the Clinical Section, the aetiology, pathogenesis, prevention and treatment of age-related diseases are discussed from a gerontological rather than a geriatric viewpoint. The Experi-mental Section contains up-to-date contributions from basic gerontological research. Pa-pers dealing with behavioural development and related topics are placed in the Behavioural Science Section. Basic aspects of regeneration in different experimental biological systems as well as in the context of medical applications are dealt with in the Regenerative Section whereas the Technological Section contains important information on major technological advances for the elderly. Providing a primary source of high-quality papers covering all as-pects of aging in humans and animals, Gerontology serves as an ideal information tool for all readers interested in the topic of aging from a broad perspective.

ISSN Print Edition: 0304-324XISSN Online Edition: 1423-0003

Journal Homepage: www.karger.com/gerBibliographic Indices: This journal is regularly listed in bibliographic services, including PubMed/MED-LINE, Web of Science, Google Scholar, Scopus, Em-base.

Publication Data: Gerontology is published 6 times a year. Volume 66 with 6 issues appears in 2020.

Copyright: © 2020 S. Karger AG, Basel (Switzerland). All rights reserved. No part of this publication may be translated into other languages, reproduced or uti-lized in any form or by any means, electronic or me-chanical, including photocopying, recording, micro-copying, or by any information storage and retrieval system, without permission in writing from the pub-lisher.

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Contents

Vol. 66, No. 5, 2020

Clinical Section

Viewpoint

419 Lymphatic Capillaries in AgingJakic, B. (Innsbruck/Uppsala); Kerjaschki, D. (Vienna); Wick, G. (Innsbruck)

Debate

427 The Crucial Role of Nurses and Social Workers in Initiating End-of-Life Communication to Reduce Overtreatment in the Midst of the COVID-19 PandemicRaftery, C. (Southport, QLD); Lewis, E. (Randwick, NSW); Cardona, M. (Southport, QLD/Robina, QLD)

Short Communication

431 Immunological Implications of Physical Inactivity among Older Adults during the COVID-19 PandemicDamiot, A.; Pinto, A.J. (São Paulo); Turner, J.E. (Bath); Gualano, B. (São Paulo)

Original Papers

439 Negative Association between Caloric Intake and Estimated Glomerular Filtration Rate in a Chinese Population: Mediation Models Involving Mitochondrial FunctionMa, C.; He, S.; Li, P.; Zhang, H.; Li, W.; Li, Y. (Beijing)

447 The Prospective Studies of Atherosclerosis (Proof-ATHERO) Consortium: Design and RationaleTschiderer, L.; Seekircher, L.; Klingenschmid, G. (Innsbruck); Izzo, R. (Naples); Baldassarre, D. (Milan); Iglseder, B. (Salzburg); Calabresi, L. (Milan); Liu, J. (Beijing); Price, J.F. (Edinburgh); Bae, J.-H. (Daejeon); Brouwers, F.P. (The Hague); de Groot, E. (Eindhoven/Lunteren); Schmidt, C.; Bergström, G. (Gothenburg); Aşçi, G. (Bornova-Izmir); Gresele, P. (Perugia); Okazaki, S. (Osaka); Kapellas, K. (Adelaide, SA); Landecho, M.F. (Navarra); Sattar, N. (Glasgow); Agewall, S. (Oslo); Zou, Z.-Y. (Beijing); Byrne, C.D. (Southampton); Nanayakkara, P.W.B. (Amsterdam); Papagianni, A. (Thessaloniki); Witham, M.D. (Newcastle); Bernal, E. (Murcia); Ekart, R. (Maribor); van Agtmael, M.A. (Amsterdam); Neves, M.F. (Rio de Janeiro); Sato, E. (Chiba); Ezhov, M. (Moscow); Walters, M. (Glasgow); Olsen, M.H. (Odense); Stolić, R. (Kragujevac); Zozulińska-Ziółkiewicz, D.A. (Poznan); Hanefeld, M. (Dresden); Staub, D. (Basel); Nagai, M. (Hiroshima); Nieuwkerk, P.T. (Amsterdam); Huisman, M.V. (Leiden); Kato, A. (Hamamatsu); Honda, H. (Tokyo); Parraga, G. (London, ON); Magliano, D. (Melbourne, VIC); Gabriel, R. (Madrid); Rundek, T. (Miami, FL); Espeland, M.A. (Winston-Salem, NC); Kiechl, S.; Willeit, J. (Innsbruck); Lind, L. (Uppsala); Empana, J.P. (Paris); Lonn, E. (Hamilton, ON); Tuomainen, T.-P. (Kuopio); Catapano, A. (Milan); Chien, K.-L. (Taipei); Sander, D. (Feldafing/Munich); Kavousi, M. (Rotterdam); Beulens, J.W.J. (Amsterdam); Bots, M.L. (Utrecht); Sweeting, M.J. (Leicester/Cambridge); Lorenz, M.W. (Frankfurt am Main); Willeit, P. (Innsbruck/Cambridge)

460 Which Factors Contribute to Frailty among the Oldest Old? Results of the Multicentre Prospective AgeCoDe and AgeQualiDe StudyHajek, A.; Brettschneider, C. (Hamburg); Röhr, S.; Gühne, U. (Leipzig); van der Leeden, C.; Lühmann, D. (Hamburg); Mamone, S.; Wiese, B. (Hanover); Weyerer, S.; Werle, J. (Mannheim); Fuchs, A.; Pentzek, M. (Düsseldorf); Weeg, D.; Mösch, E. (Munich); Heser, K.; Wagner, M.; Maier, W. (Bonn); Riedel-Heller, S.G. (Leipzig); Scherer, M.; König, H.-H. (Hamburg)

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467 Clinical Characteristics of Elderly Patients with COVID-19 in Hunan Province, China: A Multicenter, Retrospective StudyGuo, T.; Shen, Q.; Guo, W.; He, W.; Li, J.; Zhang, Y. (Changsha); Wang, Y. (Zhuzhou); Zhou, Z. (Changsha); Deng, D. (Shaoyang); Ouyang, X. (Changsha); Xiang, Z. (Huaihua); Jiang, M. (Xiangtan); Liang, M. (Xiangxi); Huang, P. (Zhuzhou); Peng, Z.; Xiang, X. (Changsha); Liu, W. (Yueyang); Luo, H.; Chen, P.; Peng, H. (Changsha)

Behavioral Science Section

Mini-Review

476 Psychological Resilience as an Emergent Characteristic for Well-Being: A Pragmatic ViewTay, P.K.C. (Singapore); Lim, K.K. (Singapore/London)

Original Papers

484 A Mixed-Method Study on Strategies in Everyday Personal Goals among Community-Dwelling Older AdultsJoly-Burra, E. (Geneva); Van der Linden, M. (Geneva/Liège); Ghisletta, P. (Geneva/Brig)

494 Executive Control, Alerting, Updating, and Falls in Cognitively Healthy Older AdultsZhang, C.; Dong, X.; Ding, M.; Chen, X. (Guangzhou); Shan, X. (Beijing); Ouyang, H.; Tao, Q. (Guangzhou)

Technological Section

Original Paper

506 A Proactive Mobile Health Application Program for Promoting Self-Care Health Management among Older Adults in the Community: Study Protocol of a Three-Arm Randomized Controlled TrialWong, A.K.C.; Wong, F.K.Y.; Chang, K.K.P. (Hong Kong)

Experimental Section

Original Paper

514 Natural Selection at the NHLH2 Core Promoter Exceptionally Long CA-Repeat in Human and Disease-Only Genotypes in Late-Onset Neurocognitive DisorderAfshar, H. (Tehran); Adelirad, F. (Tabriz); Kowsari, A.; Kalhor, N. (Qom); Delbari, A. (Tehran); Najafipour, R. (Qazvin); Foroughan, M.; Bozorgmehr, A.; Khamse, S. (Tehran); Nazaripanah, N. (Tabriz); Ohadi, M. (Tehran)

Concise but fully substantiated international reports of clinically ori-ented research into the science and current management of uro-genital disorders form the nucleus of original as well as basic research papers. These are supplemented by up-to-date reviews by interna-tional experts on the state-of-the-art of key topics of clinical urologi-cal practice. Essential topics receiving regular coverage include the introduction of new techniques and instrumentation as well as the evaluation of new functional tests and diagnostic methods. Special attention is given to advances in new surgical techniques and clinical oncology. The regular publication of selected case reports represents the great variation in urological disease and illustrates treatment solu-tions in singular cases.

Urologia InternationalisFounded: 1955Category: Clinical ResearchFields of Interest: Urology, Andrology

Listed in bibliographic services, including: PubMed/MEDLINE, Web of Science, Google Scholar, Scopus, Embase

2019: Volumes 102, 1034 issues per volumeLanguage: EnglishISSN 0042–1138e-ISSN 1423–0399

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An independent international forum for clinically oriented research

Impact Factor: 1.508

Offi cial Scientifi c Journal

Deutsche Gesellschaft für Urologie

EditorsM.P. Wirth, DresdenO.W. Hakenberg, RostockD. Castro-Diaz, Santa Cruz de TenerifeB. Wullich, Erlangen

Official Scientific Journal Deutsche Gesellschaft für Urologie

Treatment

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SmoSUFU

GLI

GLI

Stemness, survival, proliferationTreatment resistance

Wnt

Axin

LRP

Axin APC

TCF/Lef

NotchDelta, Jagged

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PCa stem cellsPCa cells

Selected contributions• The 2017 Update of the German Clinical Guideline on Epidemiology, Diagnostics, Therapy, Prevention, and Management of Uncomplicated Urinary Tract Infections in Adult Patients. Part II: Therapy and Prevention: Kranz, J. (Eschweiler/Berlin); Schmidt, S. (Berlin); Lebert, C. (Nürnberg); Schneidewind, L. (Berlin/Greifswald); Mandraka, F. (Freiburg); Kunze, M. (Cologne); Helbig, S. (Dresden); Vahlensieck, W. (Bad Nauheim); Naber, K. (Munich); Schmiemann, G. (Bremen); Wagenlehner, F.M. (Giessen)

• Health-Related Quality of Life after Radical Cystectomy for Bladder Can-cer in Elderly Patients with Ileal Orthotopic Neobladder or Ileal Conduit: Results from a Multicentre Cross-Sectional Study Using Validated Ques-tionnaires: Cerruto, M.A. (Verona); D’Elia, C. (Bolzano); Siracusano, S.; Saleh, O.; Gacci, M. (Florence); Cacciamani, G.; De Marco, V.; Porcaro, A.B.; Balzarro, M.; Niero, M.; Lonardi, C. (Verona); Iafrate, M. (Padua); Bassi, P. (Rome); Imbimbo, C. (Naples); Racioppi, M. (Rome); Talamini, R. (Aviano); Ciciliato, S. (Trieste); Serni, S.; Carini, M. (Florence); Verze, P. (Naples); Artibani, W. (Verona)

• Evaluation of Magnetic Resonance Imaging/Ultrasound-Fusion Biopsy in Patients with Low-Risk Prostate Cancer Under Active Surveillance Under-going Surveillance Biopsy: Borkowetz, A.; Renner, T.; Platzek, I.; Toma, M.; Herout, R.; Baunacke, M.; Groeben, C.; Huber, J.; Laniado, M.; Baretton, G.B.; Froehner, M.; Zastrow, S.; Wirth, M.P. (Dresden)

• Risk Factors for Failure of Male Slings and Artificial Urinary Sphincters: Results from a Large Middle European Cohort Study: Hüsch, T. (Mainz); Kretschmer, A. (Munich/Vancouver, BC); Thomsen, F.; Kronlachner, D. (Frankfurt); Kurosch, M. (Mainz); Obaje, A. (Hildesheim); Anding, R. (Bonn); Pottek, T. (Hamburg); Rose, A. (Duisburg); Olianas, R. (Lüneburg); Friedl, A. (Vienna); Hübner, W. (Korneuburg); Homberg, R. (Hamm); Pfitzenmaier, J. (Bielefeld); Grein, U. (Schwelm); Queissert, F. (Muenster); Naumann, C.M. (Kiel); Schweiger, J. (Erfurt); Wotzka, C. (Stuttgart); Nyarangi-Dix, J. (Heidelberg); Hofmann, T. (Schwäbisch Hall); Ulm, K.; Bauer, R.M. (Munich); Haferkamp, A. (Mainz); Debates on Male Incontinence (DOMINO-Project)

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https://www.karger.com/Journal/Issue/279707

Although laboratory and clinical cancer research need to be closely linked, ob-servations at the basic level often remain removed from medical applications. This journal works to accelerate the translation of experimental results into the clinic, and back again into the laboratory for further investigation. The fundamen-tal purpose of this effort is to advance clinically-relevant knowledge of cancer, and improve the outcome of prevention, diagnosis and treatment of malignant disease. The journal publishes significant clinical studies from cancer programs around the world, along with important translational laboratory findings, mini-reviews (invited and submitted) and in-depth discussions of evolving and con-troversial topics in the oncology arena. A unique feature of the journal is a section which focuses on rapid peer-review and subsequent publication of short reports of phase 1 and phase 2 clinical cancer trials, with a goal of insuring that high-quality clinical cancer research quickly enters the public domain, regardless of the trial’s ultimate conclusions regarding efficacy or toxicity.

OncologyFounded: 1948Category: Clinical and Basic ResearchField of Interest: Oncology

Listed in bibliographic services, including:PubMed/MEDLINE, Web of Science, Google Scholar, Scopus, Embase

2019: Volumes 96, 976 issues per volumeLanguage: EnglishISSN 0030–2414e-ISSN 1423–0232 More information at w w w.karger.com/ocl

Your source for important clinical and translational laboratory studies from around the world

International Journal of Cancer Research and Treatment

Editor-in-ChiefM. Markman, Philadelphia, PA

Regional Editor JapanO. Hino, Tokyo

International Journal of Cancer Research and Treatment

Selected contributions• Immune Checkpoint Inhibition in Hepatocellular Carcinoma: Basics and Ongoing Clinical Trials: Kudo, M. (Osaka-Sayama)

• The New Combination Docetaxel, Prednisone and Curcumin in Patients with Castration-Resistant Prostate Cancer: A Pilot Phase II Study: Mahammedi, H.; Planchat, E.; Pouget, M.; Durando, X. (Clermont-Ferrand); Curé, H. (Reims); Guy, L.; Van-Praagh, I. (Clermont-Ferrand); Savareux, L.; Atger, M. (Beaumont); Bayet-Robert, M.; Gadea, E.; Abrial, C.; Thivat, E.; Chollet, P. (Clermont-Ferrand); Eymard, J.-C. (Reims)

• Global Epidemiology of Head and Neck Cancers: A Continuing Challenge: Gupta, B.; Johnson, N.W. (Gold Coast, QLD); Kumar, N. (Pune)

• Diabetes and Body Mass Index Are Associated with Neuropathy and Prognosis in Colon Cancer Patients Treated with Capecitabine and Oxaliplatin Adjuvant Chemotherapy: Ottaiano, A.; Nappi, A.; Tafuto, S.; Nasti, G.; De Divitiis, C.; Romano, C.; Cassata, A.; Casaretti, R.; Silvestro, L.; Avallone, A.; Capuozzo, M.; Capozzi, M.; Maiolino, P.; Quagliariello, V.; Scala, S.; Iaffaioli, V.R. (Naples)

• miRNA-503 Promotes Tumor Progression and Is Associated with Early Recurrence and Poor Prognosis in Human Colorectal Cancer: Noguchi, T.; Toiyama, Y.; Kitajima, T.; Imaoka, H.; Hiro, J.; Saigusa, S.; Tanaka, K.; Inoue, Y.; Mohri, Y. (Tsu); Toden, S. (Dallas, TX); Kusunoki, M. (Tsu)

• A Novel Scoring System Based on Fibrinogen and the Neutrophil-Lymphocyte Ratio as a Predictor of Chemotherapy Response and Prognosis in Patients with Advanced Gastric Cancer: Arigami, T.; Uenosono, Y.; Ishigami, S.; Okubo, K.; Kijima, T.; Yanagita, S.; Okumura, H.; Uchikado, Y.; Kijima, Y.; Nakajo, A; Kurahara, H.; Kita, Y.; Mori, S.; Maemura, K.; Natsugoe, S. (Kagoshima)

• Results from a Phase I Study of Lapatinib with Gemcitabine and Cisplatin in Advanced or Metastatic Bladder Cancer: EORTC Trial 30061: Cerbone, L.; Sternberg, C.N. (Rome); Sengeløv, L. (Herlev); Agerbaek, M. (Aarhus); Van Herpen, C. (Nijmegen); Marreaud, S.; Collette, S. (Brussels); Zhang, J. (Research Triangle Park, NC); Daugaard, G. (Copenhagen)

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