Cleistanthane diterpenes from the seed of Caesalpinia sappan and their antiausterity activity...
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Supplimentary material Cleistanthane Diterpenes from the Seed of Caesalpinia sappan and their antiausterity activity against PANC-1 human pancreatic cancer cell line Nguyen Xuan Hai, a Nguyen Thi Thanh Mai, a Nguyen Anh Thy, a Nguyen Thi Y Nhi, a Phan Thi Anh Dao, a Ho Thi Phuoc, a Phan Nguyen Huu Trong, a Dang Hoang Phu, a Nguyen Trung Nhan, a Jun-ya Ueda, b Suresh Awale* ,b a Faculty of Chemistry, University of Science, Vietnam National University-Hochiminh City, Vietnam b Frontier Research Core for Life Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan *Corresponding author at: Frontier Research Core for Life Sciences, University of Toyama, 2630- Sugitani, Toyama 930-0194, Japan. Tel.: +81 076-434-7640; fax: +81 076-434-7640; E-mail: [email protected] (S. Awale). Contents 1 H NMR, 13 C NMR, DEPT, COSY, HSQC, HMBC, NOESY and MS spectrum of tomocinon (1) S1− S8 1 H NMR, 13 C NMR, DEPT, COSY, HSQC, HMBC, NOESY and MS spectrum of tomocinol A (2) S9− S16 1 H NMR, 13 C NMR, DEPT, COSY, HSQC, HMBC, NOESY and MS spectrum of tomocinol B (3) S17− S24
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Transcript of Cleistanthane diterpenes from the seed of Caesalpinia sappan and their antiausterity activity...
Supplimentary material
Cleistanthane Diterpenes from the Seed of Caesalpinia sappan and their
antiausterity activity against PANC-1 human pancreatic cancer cell line
Nguyen Xuan Hai,a Nguyen Thi Thanh Mai,a Nguyen Anh Thy,a Nguyen Thi Y Nhi,a Phan Thi Anh
Dao,a Ho Thi Phuoc,a Phan Nguyen Huu Trong,a Dang Hoang Phu,a Nguyen Trung Nhan,a Jun-ya Ueda,b
Suresh Awale*,b
a Faculty of Chemistry, University of Science, Vietnam National University-Hochiminh City, Vietnam
bFrontier Research Core for Life Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194,
Japan
*Corresponding author at: Frontier Research Core for Life Sciences, University of Toyama, 2630-
Sugitani, Toyama 930-0194, Japan. Tel.: +81 076-434-7640; fax: +81 076-434-7640; E-mail:
[email protected] (S. Awale).
Contents
1H NMR, 13C NMR, DEPT, COSY, HSQC, HMBC, NOESY and MS spectrum of tomocinon (1)
S1−S8
1H NMR, 13C NMR, DEPT, COSY, HSQC, HMBC, NOESY and MS spectrum of tomocinol A (2)
S9−S16
1H NMR, 13C NMR, DEPT, COSY, HSQC, HMBC, NOESY and MS spectrum of tomocinol B (3)
S17−S24
Fig. S1 1H
NM
R spectrum
of compound 1 (C
DC
l3 , 500 MH
z)
Fig. S2 13C
NM
R spectrum
of compound 1 (C
DC
l3 , 500 MH
z)
Fig. S3 DEPT spectrum
of compound 1 (C
DC
l3 )
Fig. S4 C
OSY
spectrum of com
pound 1 (CD
Cl3 )
Fig. S5 H
SQC
spectrum of com
pound 1 (CD
Cl3 )
Fig. S6 H
MB
C spectrum
of compound 1 (C
DC
l3 )
Fig. S7 N
OESY
spectrum of com
pound 1 (CD
Cl3 )
Fig. S8 M
S spectrum of com
pound 1
Fig. S9 1H
NM
R spectrum
of compound 2 (C
DC
l3 , 500 MH
z)
Fig. S10 13C
NM
R spectrum
of compound 2 (C
DC
l3 , 500 MH
z)
Fig. S11 D
EPT spectrum of com
pound 2 (CD
Cl3 )
Fig. S12 C
OSY
spectrum of com
pound 2 (CD
Cl3 )
Fig. S13 H
SQC
spectrum of com
pound 2 (CD
Cl3 )
Fig. S14 H
MB
C spectrum
of compound 2 (C
DC
l3 )
Fig. S25 N
OESY
spectrum of com
pound 2 (CD
Cl3 )
Fig. S16 M
S spectrum of com
pound 2
Fig. S17 1H
NM
R spectrum
of compound 3 (C
DC
l3 , 500 MH
z)
Fig. S18 13C
NM
R spectrum
of compound 3 (C
DC
l3 , 500 MH
z)
Fig. S19 D
EPT spectrum of com
pound 3 (CD
Cl3 )
Fig. S20 C
OSY
spectrum of com
pound 3 (CD
Cl3 )
Fig. S21 H
SQC
spectrum of com
pound 3 (CD
Cl3 )
Fig. S22 H
MB
C spectrum
of compound 3 (C
DC
l3 )
Fig. S23 N
OESY
spectrum of com
pound 3 (CD
Cl3 )
Fig. S24 M
S spectrum of com
pound 3
