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EVALUASI KESTABILANEVALUASI KESTABILAN

SUSPENSISUSPENSI

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MetodeMetode EvaluasiEvaluasi SuspensiSuspensi

1. Volume1. Volume SedimentasiSedimentasi ( F )( F )

F = HF = HUU/H/H00 x 100 %x 100 %HargaHarga F = > 1 1 pressure in particle 2

S(a)1 > S(a)2

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Ostwald ripening (2)

L

(a)1

L

(a)2

x(a)1 x(a)2S(a)1 S(a)2

S(a)1 > S(a)2

L(a)1 > L(a)2

L(a) + RT ln x(a)1 > L

(a) + RT ln x(a)2

At equilibrium: S(a)1 = L(a)1 en S(a)2 = L(a)2

x(a)1> x(a)2

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Packaging and Storage of Suspensions:Packaging and Storage of Suspensions:

1) Should be packaged in wide mouth1) Should be packaged in wide mouth

containers having adequate air space abovecontainers having adequate air space abovethe liquid.the liquid.

2) Should be stored in tight containers2) Should be stored in tight containers

protected from: freezing and excessiveprotected from: freezing and excessiveheat & lightheat & light

3) Label:3) Label: "Shake Before Use""Shake Before Use" to ensureto ensure

uniform distribution of solid particles anduniform distribution of solid particles andthereby uniform and proper dosage.thereby uniform and proper dosage.

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ASA

SA

SA