Thalamic atrophy and cognition in multiple sclerosis

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Thalamic atrophy and cognition in multiple sclerosis.(PMID:17875909)

Houtchens MK, Benedict RH, Killiany R, Sharma J, Jaisani Z, Singh B, Weinstock-Guttman B, Guttmann CR, Bakshi R

Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Partners MS Center, Boston, MA 02115, USA.Neurology [2007, 69(12):1213-23]

Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural

DOI: 10.1212/01.wnl.0000276992.17011.b5

Abstract Highlight Terms

Diseases(4) Chemicals(1)

OBJECTIVES: Recent studies have indicated that brain atrophy is more closely associated with cognitive impairment in multiplesclerosis (MS) than are conventional MRI lesion measures. Enlargement of the third ventricle shows a particularly strongcorrelation with cognitive impairment, suggesting clinical relevance of damage to surrounding structures, such as the thalamus.Previous imaging and pathology studies have demonstrated thalamic involvement in MS. In this study, we tested the hypothesisthat thalamic volume is lower in MS than in normal subjects, and that thalamic atrophy in MS correlates with cognitive function.

METHODS: We studied 79 patients with MS and 16 normal subjects. A subgroup of 31 MS subjects underwent cognitive testing.The thalamus was segmented in whole from three-dimensional MRI scans. We also determined whole brain atrophy (brainparenchymal fraction), third ventricular width, and whole brain T2-weighted (fluid-attenuated inversion recovery) hyperintense,T1 hypointense, and gadolinium-enhanced lesion volumes.

RESULTS: Normalized thalamic volume was 16.8% lower in the MS group (p < 0.0001) vs controls. Cognitive performance in alldomains was moderately to strongly related to thalamic volume in the MS group (r = 0.506 to 0.724, p < 0.005), and thalamicvolume entered and remained in all regression models predicting cognitive performance. Thalamic volume showed a weakrelationship to physical disability score (r = -0.316, p = 0.005).

CONCLUSION: These findings suggest that thalamic atrophy is a clinically relevant biomarker of the neurodegenerative diseaseprocess in multiple sclerosis.

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(PMID:18727673)

Short-latency afferent inhibition predicts verbal memory performance in patients with multiple sclerosis.

(PMID:18854915)

Cognitive changes in multiple sclerosis.

(PMID:18928350)

Strongly reduced volumes of putamen and thalamus in Alzheimer's disease: an MRI study.

(PMID:19022861)

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(PMID:19022862)

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(PMID:19162280)

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(PMID:19168189)

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(PMID:19281850)

Thalamic atrophy and cognition in multiple sclerosis. - Abstract - UK Pu... http://ukpmc.ac.uk/abstract/MED/17875909

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Quantification and clinical relevance of brain atrophy in multiple sclerosis: a review.

(PMID:19353226)

Regional white matter atrophy--based classification of multiple sclerosis in cross-sectional and longitudinal data.

(PMID:19696139)

Brain MRI lesion load at 1.5T and 3T versus clinical status in multiple sclerosis.

(PMID:19888926)

Thalamocortical sensorimotor circuit in multiple sclerosis: an integrated structural and electrophysiological assessment.

(PMID:20162580)

Cognition in multiple sclerosis: relevance of lesions, brain atrophy and proton MR spectroscopy.

(PMID:20635111)

MRI and cognition in multiple sclerosis.

(PMID:20635114)

Neuropsychological rehabilitation in adult multiple sclerosis.

(PMID:20640467)

Neuroimaging in multiple sclerosis: neurotherapeutic implications.

(PMID:21274685)

Magnetic resonance imaging in multiple sclerosis: the role of conventional imaging.

(PMID:21439445)

Cites the following

No data available

Reviews - displaying 100 of 109

MRI markers of destructive pathology in multiple sclerosis-related cognitive dysfunction.

(PMID:16626748)

Rovaris M, Comi G, Filippi M

Journal of the neurological sciences [2006 Jun 15;245(1-2):111-6]

Clinical and MRI assessment of brain damage in MS.

(PMID:11794475)

Comi G, Rovaris M, Leocani L, Martinelli V, Filippi M

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [2001 Nov;22 Suppl

2:S123-7]

MRI correlates of cognitive dysfunction in multiple sclerosis patients.

(PMID:10871808)

Rovaris M, Filippi M

Journal of neurovirology [2000 May;6 Suppl 2:S172-5]

[Cognitive impairment in multiple sclerosis].

(PMID:15871058)

Karlińska I, Selmaj K

Neurologia i neurochirurgia polska [2005 Mar-Apr;39(2):125-33]

Correlating brain atrophy with cognitive dysfunction, mood disturbances, and personality disorder in multiple sclerosis.

(PMID:15228758)

Benedict RH, Carone DA, Bakshi R

Journal of neuroimaging : official journal of the American Society of Neuroimaging [2004 Jul;14(3 Suppl):36S-45S]

Assessment of the damage of the cerebral hemispheres in MS using neuroimaging techniques.

(PMID:10606810)

Comi G, Rovaris M, Leocani L, Martinelli V, Filippi M

Journal of the neurological sciences [2000 Jan 15;172 Suppl 1:S63-6]


2 of 18 5/19/2011 8:56 PM

Magnetic resonance imaging measures of brain atrophy in multiple sclerosis.

(PMID:16596564)

Anderson VM, Fox NC, Miller DH

Journal of magnetic resonance imaging : JMRI [2006 May;23(5):605-18]

Cognitive impairment in multiple sclerosis.

(PMID:17495620)

Hoffmann S, Tittgemeyer M, von Cramon DY

Current opinion in neurology [2007 Jun;20(3):275-80]

Brain atrophy and cognitive impairment in multiple sclerosis: a review.

(PMID:17503128)

Lanz M, Hahn HK, Hildebrandt H

Journal of neurology [2007 May;254 Suppl 2:II43-8]

Magnetic resonance imaging in multiple sclerosis.

(PMID:16400309)

Napoli SQ, Bakshi R

Reviews in neurological diseases [2005 Summer;2(3):109-16]

Clinical-magnetic resonance imaging correlations in multiple sclerosis.

(PMID:16385015)

Zivadinov R, Leist TP

Journal of neuroimaging : official journal of the American Society of Neuroimaging [2005;15(4 Suppl):10S-21S]

Multiple sclerosis.

(PMID:17226744)

Benedict RH, Bobholz JH

Seminars in neurology [2007 Feb;27(1):78-85]

Neuropsychological impairment in systemic lupus erythematosus: a comparison with multiple sclerosis.

(PMID:18521755)

Benedict RH, Shucard JL, Zivadinov R, Shucard DW

Neuropsychology review [2008 Jun;18(2):149-66]

Cognitive dysfunction in multiple sclerosis: natural history, pathophysiology and management.

(PMID:12056920)

Bagert B, Camplair P, Bourdette D

CNS drugs [2002;16(7):445-55]

Cognitive impairment in multiple sclerosis: evidence-based analysis and recommendations.

(PMID:17659875)

Rogers JM, Panegyres PK

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [2007 Oct;14(10):919-27]

Cognitive and brain imaging measures of multiple sclerosis.

(PMID:1345734)

Pozzilli C, Passafiume D, Anzini A, Borsellino G, Koudriavsteva T, Sarlo G, Fieschi C

Italian journal of neurological sciences [1992 Dec;13(9 Suppl 14):133-6]

The relationship between MRI and PET changes and cognitive disturbances in MS.

(PMID:16650436)

Sørensen PS, Jønsson A, Mathiesen HK, Blinkenberg M, Andresen J, Hanson LG, Ravnborg M


[Cognitive impairment].

(PMID:19361675)

Reuter F, Audoin B, Rico A, Malikova I, Ranjeva JP, Pelletier J

Revue neurologique [2009 Mar;165 Suppl 4:S113-22]

Role of MRI in multiple sclerosis II: brain and spinal cord atrophy.

(PMID:14766398)

Zivadinov R, Bakshi R

Frontiers in bioscience : a journal and virtual library [2004 Jan 1;9:647-64]

T1- and T2-based MRI measures of diffuse gray matter and white matter damage in patients with multiple sclerosis.

(PMID:17425729)

Neema M, Stankiewicz J, Arora A, Dandamudi VS, Batt CE, Guss ZD, Al-Sabbagh A, Bakshi R


3 of 18 5/19/2011 8:56 PM

Journal of neuroimaging : official journal of the American Society of Neuroimaging [2007 Apr;17 Suppl 1:16S-21S]

The neuropsychiatry of multiple sclerosis: a review of recent developments.

(PMID:17415083)

Ghaffar O, Feinstein A

Current opinion in psychiatry [2007 May;20(3):278-85]

Cognitive loss in multiple sclerosis. Case reports and review of the literature.

(PMID:2644924)

Franklin GM, Nelson LM, Filley CM, Heaton RK

Archives of neurology [1989 Feb;46(2):162-7]

Cognitive impairments in multiple sclerosis: a review.

(PMID:11831417)

DeSousa EA, Albert RH, Kalman B

American journal of Alzheimer's disease and other dementias [2002 Jan-Feb;17(1):23-9]

[Neuropsychological evaluation in multiple sclerosis].

(PMID:17285522)

Arnett P, Forn C

Revista de neurologia [2007 Feb 1-15;44(3):166-72]

Central nervous system atrophy and clinical status in multiple sclerosis.

(PMID:15228757)

Zivadinov R, Bakshi R


Measuring brain atrophy in multiple sclerosis.

(PMID:17425728)

De Stefano N, Battaglini M, Smith SM


MRI relapses have significant pathologic and clinical implications in multiple sclerosis.

(PMID:17346748)

Traboulsee A

Journal of the neurological sciences [2007 May 15;256 Suppl 1:S19-22]

Multiple sclerosis-related cognitive changes: a review of cross-sectional and longitudinal studies.

(PMID:16643953)

Amato MP, Zipoli V, Portaccio E


Measurement of whole-brain atrophy in multiple sclerosis.

(PMID:15228755)

Pelletier D, Garrison K, Henry R


Transcranial brain sonography findings related to neuropsychological impairment in multiple sclerosis.

(PMID:17503129)

Walter U, Horowski S, Benecke R, Zettl UK


Gray matter involvement in multiple sclerosis.

(PMID:17325269)

Pirko I, Lucchinetti CF, Sriram S, Bakshi R

Neurology [2007 Feb 27;68(9):634-42]

Measurement of brain and spinal cord atrophy by magnetic resonance imaging as a tool to monitor multiple sclerosis.

(PMID:16385017)

Bakshi R, Dandamudi VS, Neema M, De C, Bermel RA

Journal of neuroimaging : official journal of the American Society of Neuroimaging [2005;15(4 Suppl):30S-45S]

Measures of brain and spinal cord atrophy in multiple sclerosis.

(PMID:9647295)

Losseff NA, Miller DH

Journal of neurology, neurosurgery, and psychiatry [1998 May;64 Suppl 1:S102-5]

[Disseminated sclerosis: organic basis for mental disorders and cognitive dysfunction].

(PMID:2006091)


4 of 18 5/19/2011 8:56 PM

Stenager E, Knudsen L, Jensen K

Nordisk medicin [1991;106(2):43-4, 49]

[Memory in multiple sclerosis: review of performance and relationship with clinical variables and neuroimaging].

(PMID:9951032)

Porcel J, Barrios M, Borràs C, Guàrdia J

Revista de neurologia [1998 Dec;27(160):1034-42]

[Psychological and neuropsychological problems in multiple sclerosis].

(PMID:14556476)

Béquet D, Taillia H, Clervoy P, Renard JL, Flocard F

Bulletin de l'Academie nationale de medecine [2003;187(4):683-94; discussion 695-7]

Brain and spinal cord atrophy in multiple sclerosis: role as a surrogate measure of disease progression.

(PMID:11524021)

Simon JH

CNS drugs [2001;15(6):427-36]

Rethinking cognitive function in multiple sclerosis: a nursing perspective.

(PMID:12795033)

Halper J, Kennedy P, Miller CM, Morgante L, Namey M, Ross AP

The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses [2003 Apr;35(2):70-81]

Can imaging techniques measure neuroprotection and remyelination in multiple sclerosis?

(PMID:17548573)

Zivadinov R

Neurology [2007 May 29;68(22 Suppl 3):S72-82; discussion S91-6]

Reduction of brain volume in MS. MRI and pathology findings.

(PMID:15949505)

Lycklama à Nijeholt GJ


The measurement and clinical relevance of brain atrophy in multiple sclerosis.

(PMID:16426992)

Bermel RA, Bakshi R

Lancet neurology [2006 Feb;5(2):158-70]

The role of MRS and fMRI in multiple sclerosis.

(PMID:16400835)

Tartaglia MC, Arnold DL

Advances in neurology [2006;98:185-202]

Brain reorganization during attention and memory tasks in multiple sclerosis: insights from functional MRI studies.

(PMID:16626753)

Mainero C, Pantano P, Caramia F, Pozzilli C


Neuropsychological investigations of multiple sclerosis: a clinical perspective.

(PMID:7749892)

O'Connor MG

Clinical neuroscience (New York, N.Y.) [1994;2(3-4):225-8]

[Cognitive disorders in multiple sclerosis].

(PMID:17607192)

Brochet B, Bonnet M, Deloire M, Hamel D, Salort-Campana E

Revue neurologique [2007 Jun;163(6-7):697-702]

Relation between functional brain imaging, cognitive impairment and cognitive rehabilitation in patients with multiple sclerosis.

(PMID:17503130)

Penner IK, Opwis K, Kappos L


Cognitive changes in early MS: a call for a common framework.

(PMID:16635495)

Achiron A, Barak Y


Neuroimaging in multiple sclerosis.


5 of 18 5/19/2011 8:56 PM

(PMID:17531854)

Zivadinov R, Cox JL

International review of neurobiology [2007;79:449-74]

The clinico-radiological paradox in multiple sclerosis revisited.

(PMID:12045719)

Barkhof F


[Cognitive impairment in multiple sclerosis patients].

(PMID:15754791)

Zivadinov R, Sepcić J

Lijecnicki vjesnik [2004 Jul-Aug;126(7-8):204-10]

Update on the relationships between neuropsychological dysfunction and structural MRI in multiple sclerosis.

(PMID:16533137)

Tekok-Kilic A, Benedict RH, Zivadinov R

Expert review of neurotherapeutics [2006 Mar;6(3):323-31]

Cognitive dysfunction in multiple sclerosis: a review of recent developments.

(PMID:12858063)

Bobholz JA, Rao SM


The neuropsychology of multiple sclerosis: contributions of neuroimaging research.

(PMID:11559473)

Wishart HA, Flashman L, Saykin AJ

Current psychiatry reports [2001 Oct;3(5):373-8]

[Multiple sclerosis and cognitive impairment].

(PMID:15011370)

Nishiyama H, Kuroiwa Y

Nippon rinsho. Japanese journal of clinical medicine [2004 Jan;62 Suppl:298-301]

Cognitive impairment and neurophysiological correlates in MS.

(PMID:16697015)

Magnano I, Aiello I, Piras MR


Clinical management of cognitive impairment in multiple sclerosis: a review of current evidence.

(PMID:14561373)

Amato MP, Zipoli V

International MS journal / MS Forum [2003 Aug;10(3):72-83]

[Cognitive functions in multiple sclerosis. Bibliographic review (1980-1991)].

(PMID:1419088)

Vicens A, de Castro P

Neurologia (Barcelona, Spain) [1992 Aug-Sep;7(7):185-9]

MRI to monitor treatment efficacy in multiple sclerosis.

(PMID:17425736)

Fazekas F, Soelberg-Sorensen P, Comi G, Filippi M


Therapy-induced plasticity of cognitive functions in MS patients: insights from fMRI.

(PMID:16713204)

Penner IK, Kappos L, Rausch M, Opwis K, Radü EW

Journal of physiology, Paris [2006 Jun;99(4-6):455-62]

[Cognitive and emotional disorders in multiple sclerosis. Can a management strategy be envisioned?].

(PMID:10815288)

Pelletier J, Benoit N, Montreuil M, Habib M

Pathologie-biologie [2000 Mar;48(2):121-31]

Cognitive dysfunction in multiple sclerosis: Assessment, imaging, and risk factors.

(PMID:16847772)

Wallin MT, Wilken JA, Kane R

Journal of rehabilitation research and development [2006 Jan-Feb;43(1):63-72]


6 of 18 5/19/2011 8:56 PM

Imaging the optic nerve in multiple sclerosis.

(PMID:16193891)

Rocca MA, Hickman SJ, Bö L, Agosta F, Miller DH, Comi G, Filippi M

Multiple sclerosis (Houndmills, Basingstoke, England) [2005 Oct;11(5):537-41]

The relation between MRI measures of inflammation and neurodegeneration in multiple sclerosis.

(PMID:15949493)

Inglese M, Benedetti B, Filippi M


Magnetic resonance imaging surrogates of multiple sclerosis pathology and their relationship to central nervous system atrophy.

(PMID:15228759)

Meier DS, Weiner HL, Khoury SJ, Guttmann CR


Reliability and validity of neuropsychological screening and assessment strategies in MS.

(PMID:17503124)

Benedict RH, Zivadinov R

Journal of neurology [2007 May;254 Suppl 2:II22-II25]

Measurement of spinal cord atrophy in multiple sclerosis.

(PMID:15228756)

Lin X, Tench CR, Evangelou N, Jaspan T, Constantinescu CS


Progression of leukoaraiosis and cognition.

(PMID:17673724)

Schmidt R, Petrovic K, Ropele S, Enzinger C, Fazekas F

Stroke; a journal of cerebral circulation [2007 Sep;38(9):2619-25]

Diagnostics of cognitive dysfunctions in multiple sclerosis.

(PMID:17503126)

Engel C, Greim B, Zettl UK


Biomarkers and surrogate outcomes in neurodegenerative disease: lessons from multiple sclerosis.

(PMID:15717029)

Miller DH

NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics [2004 Apr;1(2):284-94]

Influences on cognition by immunosuppression and immunomodulation in multiple sclerosis.

(PMID:17503133)

Tumani H, Uttner I


[The application of magnetic resonance imaging transfer to the study of multiple sclerosis patients: review and analysis of literature].

(PMID:12690734)

Grimaud J, Zhou LQ, Zhu YM

Revue neurologique [2002 Dec;158(12 Pt 1):1157-73]

Cognitive dysfunctions in multiple sclerosis--a "multiple disconnection syndrome"?

(PMID:17503122)

Calabrese P, Penner IK


Cognitive screening in multiple sclerosis.

(PMID:17503125)

Scherer P


Cognition and fatigue in multiple sclerosis: Potential effects of medications with central nervous system activity.

(PMID:16847774)

Oken BS, Flegal K, Zajdel D, Kishiyama SS, Lovera J, Bagert B, Bourdette DN

Journal of rehabilitation research and development [2006 Jan-Feb;43(1):83-90]

Treatment of symptoms in multiple sclerosis.

(PMID:16687058)

Schwendimann RN

Neurological research [2006 Apr;28(3):306-15]


7 of 18 5/19/2011 8:56 PM

Identification of brain atrophy with MRI in MS.

(PMID:9762685)

Thompson AJ

Multiple sclerosis (Houndmills, Basingstoke, England) [1998 Jun;4(3):257-9]

[Therapeutic management of cognitive disorders in multiple sclerosis].

(PMID:17607193)

Defer GL, Daniel F, Derache N

Revue neurologique [2007 Jun;163(6-7):703-10]

[Pathology of the thalamus and schizophrenia--an overview].

(PMID:15529234)

Danos P

Fortschritte der Neurologie-Psychiatrie [2004 Nov;72(11):621-34]

Identification and management of cognitive disorders in multiple sclerosis--a consensus approach.

(PMID:16477483)

Lensch E, Matzke M, Petereit HF, Scherer P, Schramm S, Calabrese P

Journal of neurology [2006 Feb;253 Suppl 1:I29-31]

Pain in Parkinson's disease and multiple sclerosis: its relation to the medial and lateral pain systems.

(PMID:16143170)

Scherder E, Wolters E, Polman C, Sergeant J, Swaab D

Neuroscience and biobehavioral reviews [2005;29(7):1047-56]

Brain atrophy in multiple sclerosis: what we know and would like to know.

(PMID:17262994)

Simon JH

Multiple sclerosis (Houndmills, Basingstoke, England) [2006 Dec;12(6):679-87]

Measures of cognitive and emotional changes in multiple sclerosis and underlying models of brain dysfunction.

(PMID:16626747)

Gainotti G


[Intellect and mood disorders in multiple sclerosis].

(PMID:1925376)

Montreuil M, Derouesné C

La Revue du praticien [1991 Sep 15;41(20):1913-8]

Cognitive impairment in multiple sclerosis.

(PMID:17503127)

Winkelmann A, Engel C, Apel A, Zettl UK


Neurophysiological and cognitive markers of disease evolution in multiple sclerosis.

(PMID:9762686)

Comi G, Martinelli V, Locatelli T, Leocani L, Medaglini S


Cerebral plasticity in multiple sclerosis: insights from fMRI.

(PMID:12120689)

Cifelli A, Matthews PM

Multiple sclerosis (Houndmills, Basingstoke, England) [2002 May;8(3):193-9]

Cortical lesions and brain atrophy in MS.

(PMID:15893328)

Kutzelnigg A, Lassmann H


Benign multiple sclerosis.

(PMID:16637931)

Glad S, Nyland H, Myhr KM

Acta neurologica Scandinavica. Supplementum [2006;183:55-7]

The psychosocial consequences of pediatric multiple sclerosis.

(PMID:17438240)

MacAllister WS, Boyd JR, Holland NJ, Milazzo MC, Krupp LB, International Pediatric MS Study Group


8 of 18 5/19/2011 8:56 PM

Neurology [2007 Apr 17;68(16 Suppl 2):S66-9]

Measures of physical and cognitive function and work status among individuals with multiple sclerosis: a review of the literature.

(PMID:15794498)

Pompeii LA, Moon SD, McCrory DC

Journal of occupational rehabilitation [2005 Mar;15(1):69-84]

[Impairment of cognitive processes in patients with multiple sclerosis].

(PMID:9480474)

Szafraniec L, Czernicki J

Przeglad lekarski [1997;54(7-8):572-5]

Prognostic factors in multiple sclerosis.

(PMID:17531853)

Bergamaschi R

International review of neurobiology [2007;79:423-47]

Neuropsychological evaluation and treatment of multiple sclerosis: the importance of a neuro-rehabilitation focus.

(PMID:15893679)

Pepping M, Ehde DM

Physical medicine and rehabilitation clinics of North America [2005 May;16(2):411-36, viii]

[Cognitive impairment in patients with multiple system atrophy].

(PMID:15011334)

Watanabe H, Takeda A, Kawai Y, Sobue G

Nippon rinsho. Japanese journal of clinical medicine [2004 Jan;62 Suppl:127-31]

Progress in neurorehabilitation in multiple sclerosis.

(PMID:12045723)

Thompson AJ


Cognitive function and cerebral assessment in patients who have Cushing's syndrome.

(PMID:15850847)

Bourdeau I, Bard C, Forget H, Boulanger Y, Cohen H, Lacroix A

Endocrinology and metabolism clinics of North America [2005 Jun;34(2):357-69, ix]

[Applicability of P300 potential in evaluation of cognitive processes in children and adolescents].

(PMID:17474172)

Galas-Zgorzalewicz B

Przeglad lekarski [2006;63 Suppl 1:1-3]

Pediatric multiple sclerosis.

(PMID:17122726)

Chitnis T

The neurologist [2006 Nov;12(6):299-310]

Steroids and brain atrophy in multiple sclerosis.

(PMID:15882880)

Zivadinov R


Clinical characteristics of cortical multiple sclerosis.

(PMID:16626743)

Zarei M


Other Related Articles - displaying 100 of 601

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(PMID:19542262)

Patti F, Amato MP, Trojano M, Bastianello S, Tola MR, Goretti B, Caniatti L, Di Monte E, Ferrazza P, Brescia Morra V, Lo Fermo S, Picconi O,

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(PMID:12639726)

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N

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Serial MRI in multiple sclerosis: a prospective pilot study of lesion load, whole brain volume and thalamic atrophy.

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Taylor I, Butzkueven H, Litewka L, MacGregor LR, Szoeke C, Cook M, Mitchell P, Kilpatrick TJ, Tubridy N

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [2004 Feb;11(2):153-8]

The correlation between ventricular diameter measured by transcranial sonography and clinical disability and cognitive dysfunction in patients withmultiple sclerosis.

(PMID:10987895)

Berg D, Mäurer M, Warmuth-Metz M, Rieckmann P, Becker G


MRI techniques and cognitive impairment in the early phase of relapsing-remitting multiple sclerosis.


10 of 18 5/19/2011 8:56 PM

(PMID:11338408)

Zivadinov R, De Masi R, Nasuelli D, Bragadin LM, Ukmar M, Pozzi-Mucelli RS, Grop A, Cazzato G, Zorzon M

Neuroradiology [2001 Apr;43(4):272-8]

Regional magnetic resonance imaging lesion burden and cognitive function in multiple sclerosis: a longitudinal study.

(PMID:11176944)

Sperling RA, Guttmann CR, Hohol MJ, Warfield SK, Jakab M, Parente M, Diamond EL, Daffner KR, Olek MJ, Orav EJ, Kikinis R, Jolesz FA, Weiner HL

Archives of neurology [2001 Jan;58(1):115-21]

Brain atrophy in relapsing-remitting multiple sclerosis: relationship with 'black holes', disease duration and clinical disability.

(PMID:10727693)

Paolillo A, Pozzilli C, Gasperini C, Giugni E, Mainero C, Giuliani S, Tomassini V, Millefiorini E, Bastianello S

Journal of the neurological sciences [2000 Mar 15;174(2):85-91]

The relationship of brain and cervical cord volume to disability in clinical subtypes of multiple sclerosis: a three-dimensional MRI study.

(PMID:14616292)

Lin X, Blumhardt LD, Constantinescu CS

Acta neurologica Scandinavica [2003 Dec;108(6):401-6]

Diffusion-weighted imaging predicts cognitive impairment in multiple sclerosis.

(PMID:17613599)

Benedict RH, Bruce J, Dwyer MG, Weinstock-Guttman B, Tjoa C, Tavazzi E, Munschauer FE, Zivadinov R

Multiple sclerosis (Houndmills, Basingstoke, England) [2007 Jul;13(6):722-30]

Multiple sclerosis: hyperintense lesions in the brain on nonenhanced T1-weighted MR images evidenced as areas of T1 shortening.

(PMID:17690319)

Janardhan V, Suri S, Bakshi R

Radiology [2007 Sep;244(3):823-31]

Impact of individual cognitive profile on visuo-motor reorganization in relapsing-remitting multiple sclerosis.

(PMID:17689504)

Gioia MC, Cerasa A, Liguori M, Passamonti L, Condino F, Vercillo L, Valentino P, Clodomiro A, Quattrone A, Fera F

Brain research [2007 Sep 5;1167:71-9]

The relationship between whole brain volume and disability in multiple sclerosis: a comparison of normalized gray vs. white matter withmisclassification correction.

(PMID:15961046)

Sanfilipo MP, Benedict RH, Sharma J, Weinstock-Guttman B, Bakshi R

NeuroImage [2005 Jul 15;26(4):1068-77]

Regional lobar atrophy predicts memory impairment in multiple sclerosis.

(PMID:16091537)

Benedict RH, Zivadinov R, Carone DA, Weinstock-Guttman B, Gaines J, Maggiore C, Sharma J, Tomassi MA, Bakshi R

AJNR. American journal of neuroradiology [2005 Aug;26(7):1824-31]

Quality of life and its relationship to brain lesions and atrophy on magnetic resonance images in 60 patients with multiple sclerosis.

(PMID:11030802)

Janardhan V, Bakshi R

Archives of neurology [2000 Oct;57(10):1485-91]

Brain volumetry counterparts of cognitive impairment in patients with multiple sclerosis.

(PMID:19157420)

Sastre-Garriga J, Arévalo MJ, Renom M, Alonso J, González I, Galán I, Montalban X, Rovira A

Journal of the neurological sciences [2009 Jul 15;282(1-2):120-4]

Neocortical volume decrease in relapsing-remitting MS patients with mild cognitive impairment.

(PMID:15249616)

Amato MP, Bartolozzi ML, Zipoli V, Portaccio E, Mortilla M, Guidi L, Siracusa G, Sorbi S, Federico A, De Stefano N

Neurology [2004 Jul 13;63(1):89-93]

Association of neocortical volume changes with cognitive deterioration in relapsing-remitting multiple sclerosis.

(PMID:17698706)

Amato MP, Portaccio E, Goretti B, Zipoli V, Battaglini M, Bartolozzi ML, Stromillo ML, Guidi L, Siracusa G, Sorbi S, Federico A, De Stefano N

Archives of neurology [2007 Aug;64(8):1157-61]

Gray and white matter brain atrophy and neuropsychological impairment in multiple sclerosis.

(PMID:16534104)

Sanfilipo MP, Benedict RH, Weinstock-Guttman B, Bakshi R

Neurology [2006 Mar 14;66(5):685-92]


11 of 18 5/19/2011 8:56 PM

Cognitive decline in multiple sclerosis: impact of topographic lesion distribution on differential cognitive deficit patterns.

(PMID:19667010)

Tiemann L, Penner IK, Haupts M, Schlegel U, Calabrese P


White matter and lesion T1 relaxation times increase in parallel and correlate with disability in multiple sclerosis.

(PMID:12242554)

Parry A, Clare S, Jenkinson M, Smith S, Palace J, Matthews PM

Journal of neurology [2002 Sep;249(9):1279-86]

Frontal parenchymal atrophy measures in multiple sclerosis.

(PMID:15471374)

Locatelli L, Zivadinov R, Grop A, Zorzon M


Determination of ventricular diameters in multiple sclerosis patients with transcranial sonography (TCS)--a two year follow-up study.

(PMID:14999486)

Kallmann BA, Sauer J, Schliesser M, Warmuth-Metz M, Flachenecker P, Becker Dagger G, Rieckmann P, Mäurer M

Journal of neurology [2004 Jan;251(1):30-4]

Gray matter atrophy is related to long-term disability in multiple sclerosis.

(PMID:18570297)

Fisniku LK, Chard DT, Jackson JS, Anderson VM, Altmann DR, Miszkiel KA, Thompson AJ, Miller DH

Annals of neurology [2008 Sep;64(3):247-54]

Cognitive reserve moderates the negative effect of brain atrophy on cognitive efficiency in multiple sclerosis.

(PMID:19573279)

Sumowski JF, Chiaravalloti N, Wylie G, Deluca J

Journal of the International Neuropsychological Society : JINS [2009 Jul;15(4):606-12]

Smoking is associated with increased lesion volumes and brain atrophy in multiple sclerosis.

(PMID:19687451)

Zivadinov R, Weinstock-Guttman B, Hashmi K, Abdelrahman N, Stosic M, Dwyer M, Hussein S, Durfee J, Ramanathan M

Neurology [2009 Aug 18;73(7):504-10]

Gray matter atrophy in multiple sclerosis: a longitudinal study.

(PMID:18661561)

Fisher E, Lee JC, Nakamura K, Rudick RA

Annals of neurology [2008 Sep;64(3):255-65]

Cognitive impairment and structural brain damage in benign multiple sclerosis.

(PMID:18815387)

Rovaris M, Riccitelli G, Judica E, Possa F, Caputo D, Ghezzi A, Bertolotto A, Capra R, Falautano M, Mattioli F, Martinelli V, Comi G, Filippi M

Neurology [2008 Nov 4;71(19):1521-6]

Cognitive impairment in patients with relapsing-remitting multiple sclerosis. The correlation with MRI lesion volume.

(PMID:19105110)

Karlińska I, Siger M, Lewańska M, Selmaj K

Neurologia i neurochirurgia polska [2008 Sep-Oct;42(5):416-23]

Brain atrophy as a marker of cognitive impairment in mildly disabling relapsing-remitting multiple sclerosis.

(PMID:18727673)

Sánchez MP, Nieto A, Barroso J, Martín V, Hernández MA

European journal of neurology : the official journal of the European Federation of Neurological Societies [2008 Oct;15(10):1091-9]

Regional brain atrophy is associated with physical disability in multiple sclerosis: semiquantitative magnetic resonance imaging and relationship toclinical findings.

(PMID:11296581)

Bakshi R, Benedict RH, Bermel RA, Jacobs L

Journal of neuroimaging : official journal of the American Society of Neuroimaging [2001 Apr;11(2):129-36]

Rate of brain atrophy in benign vs early multiple sclerosis.

(PMID:19204160)

Gauthier SA, Berger AM, Liptak Z, Duan Y, Egorova S, Buckle GJ, Glanz BI, Khoury SJ, Bakshi R, Weiner HL, Guttmann CR


[Magnetic resonance imaging correlates of cognitive dysfunction in patients with multiple sclerosis].

(PMID:10935260)


12 of 18 5/19/2011 8:56 PM

Filippi M

Revista de neurologia [2000 Jun 16-30;30(12):1253-6]

Longitudinal study of cognitive dysfunction in multiple sclerosis: neuropsychological, neuroradiological, and neurophysiological findings.

(PMID:12810771)

Piras MR, Magnano I, Canu ED, Paulus KS, Satta WM, Soddu A, Conti M, Achene A, Solinas G, Aiello I

Journal of neurology, neurosurgery, and psychiatry [2003 Jul;74(7):878-85]

Cognitive correlates of supratentorial atrophy on MRI in multiple sclerosis.

(PMID:11589650)

Edwards SG, Liu C, Blumhardt LD

Acta neurologica Scandinavica [2001 Oct;104(4):214-23]

Volumes of brain atrophy and plaques correlated with neurological disability in secondary progressive multiple sclerosis.

(PMID:10426145)

Dastidar P, Heinonen T, Lehtimäki T, Ukkonen M, Peltola J, Erilä T, Laasonen E, Elovaara I

Journal of the neurological sciences [1999 May 1;165(1):36-42]

Cortical atrophy and personality in multiple sclerosis.

(PMID:18590355)

Benedict RH, Hussein S, Englert J, Dwyer MG, Abdelrahman N, Cox JL, Munschauer FE, Weinstock-Guttman B, Zivadinov R

Neuropsychology [2008 Jul;22(4):432-41]

T1 lesion load and cerebral atrophy as a marker for clinical progression in patients with multiple sclerosis. A prospective 18 months follow-upstudy.

(PMID:11509079)

Sailer M, Losseff NA, Wang L, Gawne-Cain ML, Thompson AJ, Miller DH

European journal of neurology : the official journal of the European Federation of Neurological Societies [2001 Jan;8(1):37-42]

Thalamic atrophy in Huntington's disease co-varies with cognitive performance: a morphometric MRI analysis.

(PMID:15459079)

Kassubek J, Juengling FD, Ecker D, Landwehrmeyer GB

Cerebral cortex (New York, N.Y. : 1991) [2005 Jun;15(6):846-53]

Retinal nerve fiber layer is associated with brain atrophy in multiple sclerosis.

(PMID:17938370)

Gordon-Lipkin E, Chodkowski B, Reich DS, Smith SA, Pulicken M, Balcer LJ, Frohman EM, Cutter G, Calabresi PA

Neurology [2007 Oct 16;69(16):1603-9]

Quantitative diffusion weighted imaging measures in patients with multiple sclerosis.

(PMID:17498974)

Tavazzi E, Dwyer MG, Weinstock-Guttman B, Lema J, Bastianello S, Bergamaschi R, Cosi V, Benedict RH, Munschauer FE 3rd, Zivadinov R

NeuroImage [2007 Jul 1;36(3):746-54]

Regional grey matter atrophy in clinically isolated syndromes at presentation.

(PMID:18469033)

Henry RG, Shieh M, Okuda DT, Evangelista A, Gorno-Tempini ML, Pelletier D

Journal of neurology, neurosurgery, and psychiatry [2008 Nov;79(11):1236-44]

Neuropsychological and MRI measures predict short-term evolution in benign multiple sclerosis.

(PMID:19641173)

Portaccio E, Stromillo ML, Goretti B, Zipoli V, Siracusa G, Battaglini M, Giorgio A, Bartolozzi ML, Guidi L, Sorbi S, Federico A, Amato MP, De Stefano

N

Neurology [2009 Aug 18;73(7):498-503]

Whole-brain atrophy in multiple sclerosis measured by automated versus semiautomated MR imaging segmentation.

(PMID:15205136)

Sharma J, Sanfilipo MP, Benedict RH, Weinstock-Guttman B, Munschauer FE 3rd, Bakshi R

AJNR. American journal of neuroradiology [2004 Jun-Jul;25(6):985-96]

Gray matter atrophy in patients with ischemic stroke with cognitive impairment.

(PMID:18258824)

Stebbins GT, Nyenhuis DL, Wang C, Cox JL, Freels S, Bangen K, deToledo-Morrell L, Sripathirathan K, Moseley M, Turner DA, Gabrieli JD, Gorelick

PB

Stroke; a journal of cerebral circulation [2008 Mar;39(3):785-93]

Selective caudate atrophy in multiple sclerosis: a 3D MRI parcellation study.

(PMID:12634479)

Bermel RA, Innus MD, Tjoa CW, Bakshi R


13 of 18 5/19/2011 8:56 PM

Neuroreport [2003 Mar 3;14(3):335-9]

Validation of linear cerebral atrophy markers in multiple sclerosis.

(PMID:18068987)

Butzkueven H, Kolbe SC, Jolley DJ, Brown JY, Cook MJ, van der Mei IA, Groom PS, Carey J, Eckholdt J, Rubio JP, Taylor BV, Mitchell PJ, Egan GF,

Kilpatrick TJ

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [2008 Feb;15(2):130-7]

An fMRI study of planning-related brain activity in patients with moderately advanced multiple sclerosis.

(PMID:15471372)

Lazeron RH, Rombouts SA, Scheltens P, Polman CH, Barkhof F


A three-year, multi-parametric MRI study in patients at presentation with CIS.

(PMID:18274802)

Rocca MA, Agosta F, Sormani MP, Fernando K, Tintorè M, Korteweg T, Tortorella P, Miller DH, Thompson A, Rovira A, Montalban X, Polman C,

Barkhof F, Filippi M

Journal of neurology [2008 May;255(5):683-91]

Gray matter T2 hypointensity is related to plaques and atrophy in the brains of multiple sclerosis patients.

(PMID:11266686)

Bakshi R, Dmochowski J, Shaikh ZA, Jacobs L

Journal of the neurological sciences [2001 Mar 15;185(1):19-26]

Structural and functional MRI correlates of Stroop control in benign MS.

(PMID:18041737)

Rocca MA, Valsasina P, Ceccarelli A, Absinta M, Ghezzi A, Riccitelli G, Pagani E, Falini A, Comi G, Scotti G, Filippi M

Human brain mapping [2009 Jan;30(1):276-90]

Structural brain abnormalities in multiple sclerosis patients with major depression.

(PMID:14981175)

Feinstein A, Roy P, Lobaugh N, Feinstein K, O'Connor P, Black S

Neurology [2004 Feb 24;62(4):586-90]

Brain atrophy in multiple sclerosis: impact of lesions and of damage of whole brain tissue.

(PMID:12356208)

Kalkers NF, Vrenken H, Uitdehaag BM, Polman CH, Barkhof F


Cortical cerebral metabolism correlates with MRI lesion load and cognitive dysfunction in MS.

(PMID:10680783)

Blinkenberg M, Rune K, Jensen CV, Ravnborg M, Kyllingsbaek S, Holm S, Paulson OB, Sørensen PS

Neurology [2000 Feb 8;54(3):558-64]

Is a preserved functional reserve a mechanism limiting clinical impairment in pediatric MS patients?

(PMID:19107755)

Rocca MA, Absinta M, Ghezzi A, Moiola L, Comi G, Filippi M

Human brain mapping [2009 Sep;30(9):2844-51]

Memory impairment in multiple sclerosis: correlation with deep grey matter and mesial temporal atrophy.

(PMID:18829629)

Benedict RH, Ramasamy D, Munschauer F, Weinstock-Guttman B, Zivadinov R

Journal of neurology, neurosurgery, and psychiatry [2009 Feb;80(2):201-6]

The relationship between inflammation and atrophy in clinically isolated syndromes suggestive of multiple sclerosis: a monthly MRI study aftertriple-dose gadolinium-DTPA.

(PMID:15083288)

Paolillo A, Piattella MC, Pantano P, Di Legge S, Caramia F, Russo P, Lenzi GL, Pozzilli C

Journal of neurology [2004 Apr;251(4):432-9]

Use of combined conventional and quantitative MRI to quantify pathology related to cognitive impairment in multiple sclerosis.

(PMID:17673493)

Lin X, Tench CR, Morgan PS, Constantinescu CS

Journal of neurology, neurosurgery, and psychiatry [2008 Apr;79(4):437-41]

Cognitive impairment in relapsing-remitting multiple sclerosis can be predicted by imaging performed several years earlier.

(PMID:17986503)

Summers M, Fisniku L, Anderson V, Miller D, Cipolotti L, Ron M

Multiple sclerosis (Houndmills, Basingstoke, England) [2008 Mar;14(2):197-204]


14 of 18 5/19/2011 8:56 PM

Optimizing the association between disability and biological markers in MS.

(PMID:11591845)

Kalkers NF, Bergers E, Castelijns JA, van Walderveen MA, Bot JC, Adèr HJ, Polman CH, Barkhof F

Neurology [2001 Oct 9;57(7):1253-8]

Neocortical volume decrease in relapsing-remitting multiple sclerosis with mild cognitive impairment.

(PMID:16631794)

Portaccio E, Amato MP, Bartolozzi ML, Zipoli V, Mortilla M, Guidi L, Siracusa G, Sorbi S, Federico A, De Stefano N


Brain magnetic resonance imaging correlates of cognitive impairment in multiple sclerosis.

(PMID:8340796)

Comi G, Filippi M, Martinelli V, Sirabian G, Visciani A, Campi A, Mammi S, Rovaris M, Canal N

Journal of the neurological sciences [1993 Apr;115 Suppl:S66-73]

Thalamic involvement and its impact on clinical disability in patients with multiple sclerosis: a diffusion tensor imaging study at 3T.

(PMID:19369608)

Tovar-Moll F, Evangelou IE, Chiu AW, Richert ND, Ostuni JL, Ohayon JM, Auh S, Ehrmantraut M, Talagala SL, McFarland HF, Bagnato F

AJNR. American journal of neuroradiology [2009 Aug;30(7):1380-6]

Changes in the normal appearing brain tissue and cognitive impairment in multiple sclerosis.

(PMID:10644780)

Filippi M, Tortorella C, Rovaris M, Bozzali M, Possa F, Sormani MP, Iannucci G, Comi G

Journal of neurology, neurosurgery, and psychiatry [2000 Feb;68(2):157-61]

Brain atrophy and lesion load in a large population of patients with multiple sclerosis.

(PMID:16043800)

Tedeschi G, Lavorgna L, Russo P, Prinster A, Dinacci D, Savettieri G, Quattrone A, Livrea P, Messina C, Reggio A, Bresciamorra V, Orefice G,

Paciello M, Brunetti A, Coniglio G, Bonavita S, Di Costanzo A, Bellacosa A, Valentino P, Quarantelli M, Patti F, Salemi G, Cammarata E, Simone IL,

Salvatore M, Bonavita V, Alfano B

Neurology [2005 Jul 26;65(2):280-5]

Cognitive slowing in multiple sclerosis is strongly associated with brain volume reduction.

(PMID:17263004)

Lazeron RH, de Sonneville LM, Scheltens P, Polman CH, Barkhof F

Multiple sclerosis (Houndmills, Basingstoke, England) [2006 Dec;12(6):760-8]

Brain MRI lesions and atrophy are related to depression in multiple sclerosis.

(PMID:10817583)

Bakshi R, Czarnecki D, Shaikh ZA, Priore RL, Janardhan V, Kaliszky Z, Kinkel PR

Neuroreport [2000 Apr 27;11(6):1153-8]

Diagnostic accuracy of retinal abnormalities in predicting disease activity in MS.

(PMID:17470751)

Sepulcre J, Murie-Fernandez M, Salinas-Alaman A, García-Layana A, Bejarano B, Villoslada P

Neurology [2007 May 1;68(18):1488-94]

Independent contributions of cortical gray matter atrophy and ventricle enlargement for predicting neuropsychological impairment in multiplesclerosis.

(PMID:17524670)

Tekok-Kilic A, Benedict RH, Weinstock-Guttman B, Dwyer MG, Carone D, Srinivasaraghavan B, Yella V, Abdelrahman N, Munschauer F, Bakshi R,

Zivadinov R

NeuroImage [2007 Jul 15;36(4):1294-300]

Serial neuropsychological assessment and magnetic resonance imaging analysis in multiple sclerosis.

(PMID:9267977)

Hohol MJ, Guttmann CR, Orav J, Mackin GA, Kikinis R, Khoury SJ, Jolesz FA, Weiner HL

Archives of neurology [1997 Aug;54(8):1018-25]

Cognitive impairment in probable multiple sclerosis.

(PMID:12640060)

Achiron A, Barak Y

Journal of neurology, neurosurgery, and psychiatry [2003 Apr;74(4):443-6]

Magnetic resonance imaging measures of brain and spinal cord atrophy correlate with clinical impairment in secondary progressive multiplesclerosis.

(PMID:18632782)

Furby J, Hayton T, Anderson V, Altmann D, Brenner R, Chataway J, Hughes R, Smith K, Miller D, Kapoor R


15 of 18 5/19/2011 8:56 PM

Multiple sclerosis (Houndmills, Basingstoke, England) [2008 Sep;14(8):1068-75]

Cortical lesions and cognitive impairment in multiple sclerosis.

(PMID:20635113)

Rinaldi F, Calabrese M, Grossi P, Puthenparampil M, Perini P, Gallo P

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [2010 Nov;31(Suppl

2):S235-7]

[Brain atrophy and cognitive disorder in multiple sclerosis].

(PMID:12501577)

Pál E, Kosztolányi P, Perlaky P

Orvosi hetilap [2002 Dec 1;143(48):2681-5]

Cognitive dysfunction in patients with clinically isolated syndromes or newly diagnosed multiple sclerosis.

(PMID:17623735)

Glanz BI, Holland CM, Gauthier SA, Amunwa EL, Liptak Z, Houtchens MK, Sperling RA, Khoury SJ, Guttmann CR, Weiner HL

Multiple sclerosis (Houndmills, Basingstoke, England) [2007 Sep;13(8):1004-10]

Frontal cortex atrophy predicts cognitive impairment in multiple sclerosis.

(PMID:11884654)

Benedict RH, Bakshi R, Simon JH, Priore R, Miller C, Munschauer F

The Journal of neuropsychiatry and clinical neurosciences [2002 Winter;14(1):44-51]

Depression and anxiety in multiple sclerosis. A clinical and MRI study in 95 subjects.

(PMID:11437165)

Zorzon M, de Masi R, Nasuelli D, Ukmar M, Mucelli RP, Cazzato G, Bratina A, Zivadinov R

Journal of neurology [2001 May;248(5):416-21]

Thalamic atrophy and cognition in unilateral temporal lobe epilepsy.

(PMID:18419837)

Seidenberg M, Hermann B, Pulsipher D, Morton J, Parrish J, Geary E, Guidotti L

Journal of the International Neuropsychological Society : JINS [2008 May;14(3):384-93]

Cortical atrophy is relevant in multiple sclerosis at clinical onset.

(PMID:17361339)

Calabrese M, Atzori M, Bernardi V, Morra A, Romualdi C, Rinaldi L, McAuliffe MJ, Barachino L, Perini P, Fischl B, Battistin L, Gallo P

Journal of neurology [2007 Sep;254(9):1212-20]

Medulla oblongata volume: a biomarker of spinal cord damage and disability in multiple sclerosis.

(PMID:18556361)

Liptak Z, Berger AM, Sampat MP, Charil A, Felsovalyi O, Healy BC, Hildenbrand P, Khoury SJ, Weiner HL, Bakshi R, Guttmann CR

AJNR. American journal of neuroradiology [2008 Sep;29(8):1465-70]

Infratentorial hypointense lesion volume on T1-weighted magnetic resonance imaging correlates with disability in patients with chronic cerebellarataxia due to multiple sclerosis.

(PMID:11440742)

Hickman SJ, Brierley CM, Silver NC, Moseley IF, Scolding NJ, Compston DA, Miller DH


T2 hypointensity in the deep gray matter of patients with benign multiple sclerosis.

(PMID:19482861)

Ceccarelli A, Filippi M, Neema M, Arora A, Valsasina P, Rocca MA, Healy BC, Bakshi R


Cortical/subcortical disease burden and cognitive impairment in patients with multiple sclerosis.

(PMID:10696031)

Rovaris M, Filippi M, Minicucci L, Iannucci G, Santuccio G, Possa F, Comi G

AJNR. American journal of neuroradiology [2000 Feb;21(2):402-8]

Whole-brain atrophy in multiple sclerosis measured by two segmentation processes from various MRI sequences.

(PMID:14607319)

Horsfield MA, Rovaris M, Rocca MA, Rossi P, Benedict RH, Filippi M, Bakshi R

Journal of the neurological sciences [2003 Dec 15;216(1):169-77]

Quantitative volumetric analysis of brain magnetic resonance imaging from patients with multiple sclerosis.

(PMID:9702685)

Filippi M, Mastronardo G, Rocca MA, Pereira C, Comi G

Journal of the neurological sciences [1998 Jun 30;158(2):148-53]


16 of 18 5/19/2011 8:56 PM

Lacunar lesions are independently associated with disability and cognitive impairment in CADASIL.

(PMID:17620550)

Viswanathan A, Gschwendtner A, Guichard JP, Buffon F, Cumurciuc R, O'Sullivan M, Holtmannspötter M, Pachai C, Bousser MG, Dichgans M,

Chabriat H

Neurology [2007 Jul 10;69(2):172-9]

[Reduced signal intensity of T2 weighted MR imaging of thalamus and putamen in multiple sclerosis in Japan].

(PMID:11186904)

Nishii T, Hirata A, Masaki T, Kaida K, Nakamura R, Motoyoshi K, Kamakura K

Rinsho shinkeigaku = Clinical neurology [2000 Jul;40(7):677-82]

Evidence for a direct association between cortical atrophy and cognitive impairment in relapsing-remitting MS.

(PMID:16360321)

Morgen K, Sammer G, Courtney SM, Wolters T, Melchior H, Blecker CR, Oschmann P, Kaps M, Vaitl D

NeuroImage [2006 Apr 15;30(3):891-8]

Regional hippocampal atrophy in multiple sclerosis.

(PMID:18375977)

Sicotte NL, Kern KC, Giesser BS, Arshanapalli A, Schultz A, Montag M, Wang H, Bookheimer SY

Brain : a journal of neurology [2008 Apr;131(Pt 4):1134-41]

Memory performance in multiple sclerosis patients correlates with central brain atrophy.

(PMID:16900756)

Hildebrandt H, Hahn HK, Kraus JA, Schulte-Herbrüggen A, Schwarze B, Schwendemann G

Multiple sclerosis (Houndmills, Basingstoke, England) [2006 Aug;12(4):428-36]

Relation between MR abnormalities and patterns of cognitive impairment in multiple sclerosis.

(PMID:9633700)

Rovaris M, Filippi M, Falautano M, Minicucci L, Rocca MA, Martinelli V, Comi G

Neurology [1998 Jun;50(6):1601-8]

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18 of 18 5/19/2011 8:56 PM

Thalamic atrophy and cognition in multiple sclerosis

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