Department of Biochemistry 2019 - McGill University

Department of Biochemistry 2019

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FACULTY PUBLICATIONS

2019 BEAUCHEMIN, N. Jeyakumar T, Fodil N, Van Der Kraak L, Meunier C, Cayrol R, McGregor K, Langlais D, Greenwood CMT, Beauchemin N, Gros P. Inactivation of Interferon Regulatory Factor 1 Causes Susceptibility to Colitis-Associated Colorectal Cancer. Sci Rep. 2019 Dec 11;9(1):18897. doi: 10.1038/s41598-019-55378-2. PubMed PMID: 31827213. Jeyakumar T, Beauchemin N, Gros P. Impact of the Microbiome on the Human Genome. Trends Parasitol. 2019 Oct;35(10):809-821. doi: 10.1016/j.pt.2019.07.015. Epub 2019 Aug 23. Review. PubMed PMID: 31451407. BERGHUIS, A.M. Rivera B, Nadaf J, Fahiminiya S, Apellaniz-Ruiz M, Saskin A, Chong AS, Sharma S, Wagener R, Revil T, Condello V, Harra Z, Hamel N, Sabbaghian N, Muchantef K, Thomas C, de Kock L, Hébert-Blouin MN, Bassenden AV, Rabenstein H, Mete O, Paschke R, Pusztaszeri MP, Paulus W, Berghuis A, Ragoussis J, Nikiforov YE, Siebert R, Albrecht S, Turcotte R, Hasselblatt M, Fabian MR, Foulkes WD. DGCR8 microprocessor defect characterizes familial multinodular goiter with schwannomatosis. J Clin Invest. 2019 Dec 5. pii: 130206. doi: 10.1172/JCI130206. [Epub ahead of print] PubMed PMID: 31805011. Kennedy JM, Georges A, Bassenden AV, Vidal SM, Berghuis AM, Taniuchi I, Majewski J, Lathrop M, Behr MA, Langlais D, Gros P. ZBTB7B (ThPOK) IS REQUIRED FOR PATHOGENESIS OF CEREBRAL MALARIA AND PROTECTION AGAINST PULMONARY TUBERCULOSIS. Infect Immun. 2019 Dec 2. pii: IAI.00845-19. doi: 10.1128/IAI.00845-19. [Epub ahead of print] PubMed PMID: 31792077. Feng Y, Park J, Li SG, Boutin R, Viereck P, Schilling MA, Berghuis AM, Tsantrizos YS. Chirality-Driven Mode of Binding of α-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS). J Med Chem. 2019 Nov 14;62(21):9691-9702. doi: 10.1021/acs.jmedchem.9b01104. Epub 2019 Oct 16. PubMed PMID: 31577901. Toulouse JL, Yachnin BJ, Ruediger EH, Deon D, Gagnon M, Saint-Jacques K, Ebert MCCJC, Forge D, Bastien D, Colin DY, Vanden Eynde JJ, Marinier A, Berghuis AM, Pelletier JN. Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues. ACS Omega. 2019 Jun 10;4(6):10056-10069. doi: 10.1021/acsomega.9b00640. eCollection 2019 Jun 30. PubMed PMID: 31460098; PubMed Central PMCID: PMC6648814. Gobeil SMC, Ebert MCCJC, Park J, Gagné D, Doucet N, Berghuis AM, Pleiss J, Pelletier JN. The Structural Dynamics of Engineered β-Lactamases Vary Broadly on Three Timescales yet


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Sustain Native Function. Sci Rep. 2019 Apr 30;9(1):6656. doi: 10.1038/s41598-019-42866-8. PubMed PMID: 31040324; PubMed Central PMCID: PMC6491436. Ilie A, Gao AYL, Boucher A, Park J, Berghuis AM, Hoffer MJV, Hilhorst-Hofstee Y, McKinney RA, Orlowski J. A potential gain-of-function variant of SLC9A6 leads to endosomal alkalinization and neuronal atrophy associated with Christianson Syndrome. Neurobiol Dis. 2019 Jan;121:187-204. doi: 10.1016/j.nbd.2018.10.002. Epub 2018 Oct 5. PubMed PMID: 30296617. BOUCHARD, M. Roux M, Bouchard M, Kmita M. Multifaceted Hoxa13 function in urogenital development underlies the Hand-Foot-Genital Syndrome. Hum Mol Genet. 2019 May 15;28(10):1671-1681. doi: 10.1093/hmg/ddz013. PubMed PMID: 30649340. DOSTIE, J. Gentile C, Berlivet S, Mayran A, Paquette D, Guerard-Millet F, Bajon E, Dostie J, Kmita M. PRC2-Associated Chromatin Contacts in the Developing Limb Reveal a Possible Mechanism for the Atypical Role of PRC2 in HoxA Gene Expression. Dev Cell. 2019 Jul 22;50(2):184-196.e4. doi: 10.1016/j.devcel.2019.05.021. Epub 2019 Jun 13. PubMed PMID: 31204170. Wang XQD, Cameron CJF, Paquette D, Segal D, Warsaba R, Blanchette M, Dostie J. 2C-ChIP: measuring chromatin immunoprecipitation signal from defined genomic regions with deep sequencing. BMC Genomics. 2019 Feb 28;20(1):162. doi: 10.1186/s12864-019-5532-5. PubMed PMID: 30819105; PubMed Central PMCID: PMC6394006. Xue Y, Meehan B, Macdonald E, Venneti S, Wang XQD, Witkowski L, Jelinic P, Kong T, Martinez D, Morin G, Firlit M, Abedini A, Johnson RM, Cencic R, Patibandla J, Chen H, Papadakis AI, Auguste A, de Rink I, Kerkhoven RM, Bertos N, Gotlieb WH, Clarke BA, Leary A, Witcher M, Guiot MC, Pelletier J, Dostie J, Park M, Judkins AR, Hass R, Levine DA, Rak J, Vanderhyden B, Foulkes WD, Huang S. CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary. Nat Commun. 2019 Feb 4;10(1):558. doi: 10.1038/s41467-018-06958-9. PubMed PMID: 30718512; PubMed Central PMCID: PMC6361890. Xue Y, Meehan B, Fu Z, Wang XQD, Fiset PO, Rieker R, Levins C, Kong T, Zhu X, Morin G, Skerritt L, Herpel E, Venneti S, Martinez D, Judkins AR, Jung S, Camilleri-Broet S, Gonzalez AV, Guiot MC, Lockwood WW, Spicer JD, Agaimy A, Pastor WA, Dostie J, Rak J, Foulkes WD, Huang S. SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer. Nat Commun. 2019 Feb 4;10(1):557. doi: 10.1038/s41467-019-08380-1. PubMed PMID: 30718506; PubMed Central PMCID: PMC6362083. DROUIN, J. Khetchoumian K, Balsalobre A, Mayran A, Christian H, Chénard V, St-Pierre J, Drouin J. Pituitary cell translation and secretory capacities are enhanced cell autonomously by the


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transcription factor Creb3l2. Nat Commun. 2019 Sep 3;10(1):3960. doi: 10.1038/s41467-019-11894-3. PubMed PMID: 31481663; PubMed Central PMCID: PMC6722061. Mayran A, Sochodolsky K, Khetchoumian K, Harris J, Gauthier Y, Bemmo A, Balsalobre A, Drouin J. Pioneer and nonpioneer factor cooperation drives lineage specific chromatin opening. Nat Commun. 2019 Aug 23;10(1):3807. doi: 10.1038/s41467-019-11791-9. PubMed PMID: 31444346; PubMed Central PMCID: PMC6707328. Desanlis I, Kherdjemil Y, Mayran A, Bouklouch Y, Gentile C, Sheth R, Zeller R, Drouin J, Kmita M, HOX13-dependent chromatin accessibility modulates the target repertoires of the HOX factors, BioRxiv (2019) doi.org/10.1101/789875 DUCHAINE, T.F. Donayo AO, Johnson RM, Tseng HW, Izreig S, Gariepy A, Mayya VK, Wu E, Alam R, Lussier C, Jones RG, Duchaine TF. Oncogenic Biogenesis of pri-miR-17∼92 Reveals Hierarchy and Competition among Polycistronic MicroRNAs. Mol Cell. 2019 Jul 25;75(2):340-356.e10. doi: 10.1016/j.molcel.2019.05.033. Epub 2019 Jun 26. PubMed PMID: 31253575. Tran AT, Chapman EM, Flamand MN, Yu B, Krempel SJ, Duchaine TF, Eroglu M, Derry WB. MiR-35 buffers apoptosis thresholds in the C. elegans germline by antagonizing both MAPK and core apoptosis pathways. Cell Death Differ. 2019 Dec;26(12):2637-2651. doi: 10.1038/s41418-019-0325-6. Epub 2019 Apr 5. PubMed PMID: 30952991. Mayya VK, Duchaine TF. Ciphers and Executioners: How 3'-Untranslated Regions Determine the Fate of Messenger RNAs. Front Genet. 2019 Jan 24;10:6. doi: 10.3389/fgene.2019.00006. eCollection 2019. Review. PubMed PMID: 30740123; PubMed Central PMCID: PMC6357968. FABIAN, M.R. Fakim H, Fabian MR. Communication Is Key: 5'-3' Interactions that Regulate mRNA Translation and Turnover. Adv Exp Med Biol. 2019;1203:149-164. doi: 10.1007/978-3-030-31434-7_6. PubMed PMID: 31811634. Fabian MR. Of seeds and supplements: structural insights into extended microRNA-target pairing. EMBO J. 2019 Jul 1;38(13):e102477. doi: 10.15252/embj.2019102477. Epub 2019 Jun 18. PubMed PMID: 31268603; PubMed Central PMCID: PMC6600611. Apellaniz-Ruiz M, Segni M, Kettwig M, Glüer S, Pelletier D, Nguyen VH, Wagener R, López C, Muchantef K, Bouron-Dal Soglio D, Sabbaghian N, Wu MK, Zannella S, Fabian MR, Siebert R, Menke J, Priest JR, Foulkes WD. Mesenchymal Hamartoma of the Liver and DICER1 Syndrome. N Engl J Med. 2019 May 9;380(19):1834-1842. doi: 10.1056/NEJMoa1812169. PubMed PMID: 31067372. Choquet K, Forget D, Meloche E, Dicaire MJ, Bernard G, Vanderver A, Schiffmann R, Fabian MR, Teichmann M, Coulombe B, Brais B, Kleinman CL. Leukodystrophy-associated POLR3A mutations down-regulate the RNA polymerase III transcript and important regulatory RNA


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BC200. J Biol Chem. 2019 May 3;294(18):7445-7459. doi: 10.1074/jbc.RA118.006271. Epub 2019 Mar 21. PubMed PMID: 30898877; PubMed Central PMCID: PMC6509492. Duchaine TF, Fabian MR. Mechanistic Insights into MicroRNA-Mediated Gene Silencing. Cold Spring Harb Perspect Biol. 2019 Mar 1;11(3). pii: a032771. doi: 10.1101/cshperspect.a032771. Review. PubMed PMID: 29959194. Rivera, B., Nadaf, J., Fahiminiya, S., Apellaniz-Ruiz, M., Saskin, A., Chong, A.S., Sharma, S., Wagener, R., Revil, T., Condello, V., Harra, Z., Hamel, N., Sabbaghian, N., Muchantef, K., Thomas, C., de Kock, L., Hébert-Blouin, M.N., Bassenden, A.V., Rabenstein, H., Mete, O., Paschke, R., Pusztaszeri, M.P., Paulus, W., Berghuis, A., Ragoussis, J., Nikiforov, Y.E., Siebert, R., Albrecht, S., Turcotte, R., Hasselblatt, M., Fabian, M.R. & Foulkes, W.D. (2019) DGCR8 microprocessor defect characterizes familial multinodular goiter with schwannomatosis. J. Clin. Invest. Epub ahead of print. PMID: 31805011; DOI: 10.1172/JCI130206 GALLOUZI, I.E. Janice Sánchez B, Tremblay AK, Leduc-Gaudet JP, Hall DT, Kovacs E, Ma JF, Mubaid S, Hallauer PL, Phillips BL, Vest KE, Corbett AH, Kontoyiannis DL, Hussain SNA, Hastings KEM, Di Marco S, Gallouzi IE. Depletion of HuR in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy. Nat Commun. 2019 Sep 13;10(1):4171. doi: 10.1038/s41467-019-12186-6. PubMed PMID: 31519904; PubMed Central PMCID: PMC6744452. Mubaid S, Ma JF, Omer A, Ashour K, Lian XJ, Sanchez BJ, Robinson S, Cammas A, Dormoy-Raclet V, Di Marco S, Chittur SV, Tenenbaum SA, Gallouzi IE. HuR counteracts miR-330 to promote STAT3 translation during inflammation-induced muscle wasting. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17261-17270. doi: 10.1073/pnas.1905172116. Epub 2019 Aug 12. PubMed PMID: 31405989; PubMed Central PMCID: PMC6717253. Sadek J, Omer A, Hall D, Ashour K, Gallouzi IE. Alternative polyadenylation and the stress response. Wiley Interdiscip Rev RNA. 2019 Sep;10(5):e1540. doi: 10.1002/wrna.1540. Epub 2019 May 2. Review. PubMed PMID: 31050180. Al Khatib HA, Al Thani AA, Gallouzi I, Yassine HM. Epidemiological and genetic characterization of pH1N1 and H3N2 influenza viruses circulated in MENA region during 2009-2017. BMC Infect Dis. 2019 Apr 11;19(1):314. doi: 10.1186/s12879-019-3930-6. PubMed PMID: 30971204; PubMed Central PMCID: PMC6458790. GEHRING, K. Yuan T, Yang M, Gehring K, Sampson NS. Mycobacterium tuberculosis Exploits a Heterohexameric Enoyl-CoA Hydratase Retro-Aldolase Complex for Cholesterol Catabolism. Biochemistry. 2019 Oct 15;58(41):4224-4235. doi: 10.1021/acs.biochem.9b00673. Epub 2019 Oct 7. PubMed PMID: 31568719.

https://www.ncbi.nlm.nih.gov/pubmed/31805011

https://doi.org/10.1172/JCI130206


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Yang M, Chen YS, Ichikawa M, Calles-Garcia D, Basu K, Fakih R, Bui KH, Gehring K. Cryo-electron microscopy structures of ArnA, a key enzyme for polymyxin resistance, revealed unexpected oligomerizations and domain movements. J Struct Biol. 2019 Oct 1;208(1):43-50. doi: 10.1016/j.jsb.2019.07.009. Epub 2019 Jul 22. PubMed PMID: 31344437. Zhang Z, Kozlov G, Chen YS, Gehring K. Mechanism of thienopyridone and iminothienopyridinedione inhibition of protein phosphatases. Medchemcomm. 2019 Apr 5;10(5):791-799. doi: 10.1039/c9md00175a. eCollection 2019 May 1. PubMed PMID: 31191869; PubMed Central PMCID: PMC6540955. GIGUÈRE, V. Smith HW, Hirukawa A, Sanguin-Gendreau V, Nandi I, Dufour CR, Zuo D, Tandoc K, Leibovitch M, Singh S, Rennhack JP, Swiatnicki M, Lavoie C, Papavasiliou V, Temps C, Carragher NO, Unciti-Broceta A, Savage P, Basik M, van Hoef V, Larsson O, Cooper CL, Vargas Calderon AC, Beith J, Millar E, Selinger C, Giguère V, Park M, Harris LN, Varadan V, Andrechek ER, O'Toole SA, Topisirovic I, Muller WJ. An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis. Nat Commun. 2019 Jul 1;10(1):2901. doi: 10.1038/s41467-019-10681-4. PubMed PMID: 31263101; PubMed Central PMCID: PMC6603039. Xia H, Dufour CR, Giguère V. ERRα as a Bridge Between Transcription and Function: Role in Liver Metabolism and Disease. Front Endocrinol (Lausanne). 2019 Apr 5;10:206. doi: 10.3389/fendo.2019.00206. eCollection 2019. Review. PubMed PMID: 31024446; PubMed Central PMCID: PMC6459935. Ghanbari F, Hebert-Losier A, Barry J, Poirier D, Giguere V, Mader S, Philip A. Isolation and functional characterization of a novel endogenous inverse agonist of estrogen related receptors (ERRs) from human pregnancy urine. J Steroid Biochem Mol Biol. 2019 Jul;191:105352. doi: 10.1016/j.jsbmb.2019.04.001. Epub 2019 Apr 5. PubMed PMID: 30954508. Morita M, Siddiqui N, Katsumura S, Rouya C, Larsson O, Nagashima T, Hekmatnejad B, Takahashi A, Kiyonari H, Zang M, St-Arnaud R, Oike Y, Giguère V, Topisirovic I, Okada-Hatakeyama M, Yamamoto T, Sonenberg N. Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7973-7981. doi: 10.1073/pnas.1816023116. Epub 2019 Mar 29. PubMed PMID: 30926667; PubMed Central PMCID: PMC6475422. Likhite N, Yadav V, Milliman EJ, Sopariwala DH, Lorca S, Narayana NP, Sheth M, Reineke EL, Giguère V, Narkar V. Loss of Estrogen-Related Receptor Alpha Facilitates Angiogenesis in Endothelial Cells. Mol Cell Biol. 2019 Feb 15;39(5). pii: e00411-18. doi: 10.1128/MCB.00411-18. Print 2019 Mar 1. PubMed PMID: 30602497; PubMed Central PMCID: PMC6379583. GROS, P. Jeyakumar T, Fodil N, Van Der Kraak L, Meunier C, Cayrol R, McGregor K, Langlais D, Greenwood CMT, Beauchemin N, Gros P. Inactivation of Interferon Regulatory Factor 1 Causes


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Susceptibility to Colitis-Associated Colorectal Cancer. Sci Rep. 2019 Dec 11;9(1):18897. doi: 10.1038/s41598-019-55378-2. PubMed PMID: 31827213. Kennedy JM, Georges A, Bassenden AV, Vidal SM, Berghuis AM, Taniuchi I, Majewski J, Lathrop M, Behr MA, Langlais D, Gros P. ZBTB7B (ThPOK) IS REQUIRED FOR PATHOGENESIS OF CEREBRAL MALARIA AND PROTECTION AGAINST PULMONARY TUBERCULOSIS. Infect Immun. 2019 Dec 2. pii: IAI.00845-19. doi: 10.1128/IAI.00845-19. [Epub ahead of print] PubMed PMID: 31792077. Amato KR, Jeyakumar T, Poinar H, Gros P. Shifting Climates, Foods, and Diseases: The Human Microbiome through Evolution. Bioessays. 2019 Oct;41(10):e1900034. doi: 10.1002/bies.201900034. Epub 2019 Sep 16. Review. PubMed PMID: 31524305. Jeyakumar T, Beauchemin N, Gros P. Impact of the Microbiome on the Human Genome. Trends Parasitol. 2019 Oct;35(10):809-821. doi: 10.1016/j.pt.2019.07.015. Epub 2019 Aug 23. Review. PubMed PMID: 31451407. Teyra J, Singer AU, Schmitges FW, Jaynes P, Kit Leng Lui S, Polyak MJ, Fodil N, Krieger JR, Tong J, Schwerdtfeger C, Brasher BB, Ceccarelli DFJ, Moffat J, Sicheri F, Moran MF, Gros P, Eichhorn PJA, Lenter M, Boehmelt G, Sidhu SS. Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15. Structure. 2019 Apr 2;27(4):590-605.e5. doi: 10.1016/j.str.2019.01.002. Epub 2019 Jan 31. PubMed PMID: 30713027. GUARNÉ, A. Reimer JM, Eivaskhani M, Harb I, Guarné A, Weigt M, Schmeing TM. Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility. Science. 2019 Nov 8;366(6466). pii: eaaw4388. doi: 10.1126/science.aaw4388. PubMed PMID: 31699907. Seffouh A, Jain N, Jahagirdar D, Basu K, Razi A, Ni X, Guarné A, Britton RA, Ortega J. Structural consequences of the interaction of RbgA with a 50S ribosomal subunit assembly intermediate. Nucleic Acids Res. 2019 Nov 4;47(19):10414-10425. doi: 10.1093/nar/gkz770. PubMed PMID: 31665744; PubMed Central PMCID: PMC6821245. Guarné A. The More the Merrier: When Four Interfaces Are Better Than One. Structure. 2019 Oct 1;27(10):1483-1484. doi: 10.1016/j.str.2019.09.002. PubMed PMID: 31577936. Nanji T, Gehrke EJ, Shen Y, Gloyd M, Zhang X, Firby CD, Huynh A, Razi A, Ortega J, Elliot MA, Guarné A. Streptomyces IHF uses multiple interfaces to bind DNA. Biochim Biophys Acta Gen Subj. 2019 Nov;1863(11):129405. doi: 10.1016/j.bbagen.2019.07.014. Epub 2019 Jul 31. PubMed PMID: 31376411. Razi A, Davis JH, Hao Y, Jahagirdar D, Thurlow B, Basu K, Jain N, Gomez-Blanco J, Britton RA, Vargas J, Guarné A, Woodson SA, Williamson JR, Ortega J. Role of Era in assembly and homeostasis of the ribosomal small subunit. Nucleic Acids Res. 2019 Sep 5;47(15):8301-8317. doi: 10.1093/nar/gkz571. PubMed PMID: 31265110; PubMed Central PMCID: PMC6736133. Ferrero DS, Ruiz-Arroyo VM, Soler N, Usón I, Guarné A, Verdaguer N. Supramolecular


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arrangement of the full-length Zika virus NS5. PLoS Pathog. 2019 Apr 5;15(4):e1007656. doi: 10.1371/journal.ppat.1007656. eCollection 2019 Apr. PubMed PMID: 30951555; PubMed Central PMCID: PMC6469808. Almawi AW, Scotland MK, Randall JR, Liu L, Martin HK, Sacre L, Shen Y, Pillon MC, Simmons LA, Sutton MD, Guarné A. Binding of the regulatory domain of MutL to the sliding β-clamp is species specific. Nucleic Acids Res. 2019 May 21;47(9):4831-4842. doi: 10.1093/nar/gkz115. PubMed PMID: 30916336; PubMed Central PMCID: PMC6511837. Mok MCY, Campalans A, Pillon MC, Guarné A, Radicella JP, Junop MS. Identification of an XRCC1 DNA binding activity essential for retention at sites of DNA damage. Sci Rep. 2019 Feb 28;9(1):3095. doi: 10.1038/s41598-019-39543-1. PubMed PMID: 30816207; PubMed Central PMCID: PMC6395731. Huynh A, Arnold DM, Kelton JG, Smith JW, Horsewood P, Clare R, Guarné A, Nazy I. Characterization of platelet factor 4 amino acids that bind pathogenic antibodies in heparin-induced thrombocytopenia. J Thromb Haemost. 2019 Feb;17(2):389-399. doi: 10.1111/jth.14369. Erratum in: J Thromb Haemost. 2019 Sep;17(9):1578. PubMed PMID: 30582672. Liu L, Ortiz Castro MC, Rodríguez González J, Pillon MC, Guarné A. The endonuclease domain of Bacillus subtilis MutL is functionally asymmetric. DNA Repair (Amst). 2019 Jan;73:1-6. doi: 10.1016/j.dnarep.2018.10.003. Epub 2018 Oct 24. PubMed PMID: 30391220. HUANG, S. Kong T, Ahn R, Yang K, Zhu X, Fu Z, Morin G, Bramley R, Cliffe NC, Xue Y, Kuasne H, Li Q, Jung S, Gonzalez AV, Camilleri-Broët S, Guiot MC, Park M, Ursini-Siegel J, Huang S. CD44 promotes PD-L1 expression and its tumor-intrinsic function in breast and lung cancers. Cancer Res. 2019 Nov 13. pii: canres.1108.2019. doi: 10.1158/0008-5472.CAN-19-1108. [Epub ahead of print] PubMed PMID: 31722999. Kong T, Xue Y, Cencic R, Zhu X, Monast A, Fu Z, Pilon V, Sangwan V, Guiot MC, Foulkes WD, Porco JA Jr, Park M, Pelletier J, Huang S. eIF4A Inhibitors Suppress Cell-Cycle Feedback Response and Acquired Resistance to CDK4/6 Inhibition in Cancer. Mol Cancer Ther. 2019 Nov;18(11):2158-2170. doi: 10.1158/1535-7163.MCT-19-0162. Epub 2019 Aug 8. PubMed PMID: 31395685. Shorstova T, Marques M, Su J, Johnston J, Kleinman CL, Hamel N, Huang S, Alaoui-Jamali MA, Foulkes WD, Witcher M. SWI/SNF-Compromised Cancers Are Susceptible to Bromodomain Inhibitors. Cancer Res. 2019 May 15;79(10):2761-2774. doi: 10.1158/0008-5472.CAN-18-1545. Epub 2019 Mar 15. PubMed PMID: 30877105. Xue Y, Meehan B, Macdonald E, Venneti S, Wang XQD, Witkowski L, Jelinic P, Kong T, Martinez D, Morin G, Firlit M, Abedini A, Johnson RM, Cencic R, Patibandla J, Chen H, Papadakis AI, Auguste A, de Rink I, Kerkhoven RM, Bertos N, Gotlieb WH, Clarke BA, Leary A, Witcher M, Guiot MC, Pelletier J, Dostie J, Park M, Judkins AR, Hass R, Levine DA, Rak J, Vanderhyden B, Foulkes WD, Huang S. CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary. Nat Commun. 2019 Feb


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4;10(1):558. doi: 10.1038/s41467-018-06958-9. PubMed PMID: 30718512; PubMed Central PMCID: PMC6361890. Xue Y, Meehan B, Fu Z, Wang XQD, Fiset PO, Rieker R, Levins C, Kong T, Zhu X, Morin G, Skerritt L, Herpel E, Venneti S, Martinez D, Judkins AR, Jung S, Camilleri-Broet S, Gonzalez AV, Guiot MC, Lockwood WW, Spicer JD, Agaimy A, Pastor WA, Dostie J, Rak J, Foulkes WD, Huang S. SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer. Nat Commun. 2019 Feb 4;10(1):557. doi: 10.1038/s41467-019-08380-1. PubMed PMID: 30718506; PubMed Central PMCID: PMC6362083. KAZAK, L. Bertholet AM, Chouchani ET, Kazak L, Angelin A, Fedorenko A, Long JZ, Vidoni S, Garrity R, Cho J, Terada N, Wallace DC, Spiegelman BM, Kirichok Y. H(+) transport is an integral function of the mitochondrial ADP/ATP carrier. Nature. 2019 Jul;571(7766):515-520. doi: 10.1038/s41586-019-1400-3. Epub 2019 Jul 24. PubMed PMID: 31341297; PubMed Central PMCID: PMC6662629. Papadopoli D, Boulay K, Kazak L, Pollak M, Mallette F, Topisirovic I, Hulea L. mTOR as a central regulator of lifespan and aging. F1000Res. 2019 Jul 2;8. pii: F1000 Faculty Rev-998. doi: 10.12688/f1000research.17196.1. eCollection 2019. Review. PubMed PMID: 31316753; PubMed Central PMCID: PMC6611156. Kazak L, Rahbani JF, Samborska B, Lu GZ, Jedrychowski MP, Lajoie M, Zhang S, Ramsay LC, Dou FY, Tenen D, Chouchani ET, Dzeja P, Watson IR, Tsai L, Rosen ED, Spiegelman BM. Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity. Nat Metab. 2019;1(3):360-370. doi: 10.1038/s42255-019-0035-x. Epub 2019 Feb 25. PubMed PMID: 31161155; PubMed Central PMCID: PMC6544051. Dumesic PA, Egan DF, Gut P, Tran MT, Parisi A, Chatterjee N, Jedrychowski M, Paschini M, Kazak L, Wilensky SE, Dou F, Bogoslavski D, Cartier JA, Perrimon N, Kajimura S, Parikh SM, Spiegelman BM. An Evolutionarily Conserved uORF Regulates PGC1α and Oxidative Metabolism in Mice, Flies, and Bluefin Tuna. Cell Metab. 2019 Jul 2;30(1):190-200.e6. doi: 10.1016/j.cmet.2019.04.013. Epub 2019 May 16. PubMed PMID: 31105043; PubMed Central PMCID: PMC6620024. Chouchani ET, Kazak L, Spiegelman BM. New Advances in Adaptive Thermogenesis: UCP1 and Beyond. Cell Metab. 2019 Jan 8;29(1):27-37. doi: 10.1016/j.cmet.2018.11.002. Epub 2018 Nov 29. Review. PubMed PMID: 30503034. KISS, R.S. Ratemi Z, Kiss RS and Rocheleau CE. C. elegans rab-18 mutants display reduced lipid content under fed and fasted conditions. microPublication Biology. 2019. 10.17912/ micro pub. biology. 000188


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Department of Biochemistry 2019 - McGill University

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