Slide 1

Wound HealingPembimbing:

dr. DEDDY SAPUTRA, SpBP-REPresented by:Indra

Balut luka2200 SMPlester Cuci lukaFase-fase penyembuhan EarlyIntermediateLateTerminalInflamasi Seluler, angio, epitelKolagen, kontraksiRemodeling 4

Early wound healingLuka apapun perdarahanHemostasis Kerusakan seluler INFLAMASIPicu proses penyembuhan Coagulation Cascade

Inflamation Neutrofil Makrofag Limfosit Fagosit, MMPs, stimulate prolif fibroblas, produxi kolagenIntermediate Wound HealingKemotaksis sel mesenkimEpitelialisasi Proliferasi sel mesenkim angiogenesisFibroblas Late Wound HealingSintesa kolagen Wound contraction Terminal Wound HealingScar RemodellingKolagen dengan air dan GAGsCytokines & Growth FactorsEpidermal growth factor Fibroblast growth factor Platelet-derived growth factorTransforming growth factor Aktifitas kolagenNeovaskularisai Sintesa fibronektin Migrasi dan proliferasi sel endotelKemotaksis neutrofil dan makrofagThe most potent stimulant collagen synthesis15Gangguan penyembuhan luka

Scar

Hipertrofik scar Keloid Widened-scar formationParut abnormal THANK YOU