Patofisiologi Parkinson 31 March

5
Patofisiologi

Transcript of Patofisiologi Parkinson 31 March

Page 1: Patofisiologi Parkinson 31 March

Patofisiologi

Page 2: Patofisiologi Parkinson 31 March

Anatomi Ganglia Basalis

Allan RH, Samuels MA, editors. Adams and Victor’s Principles of Neurology. 9th ed. New York: McGraw Hill; 2009.pp 61-77)

Page 3: Patofisiologi Parkinson 31 March

Dopamin pada Ganglia Basalis

• Sintesis dopamin dilakukan pada substansia nigra pars kompakta

• Reseptor D1 pada Striatum memberikan efek eksitatori pada neuron putamen yang merupakan neuron asal yang membentuk jalur langsung striaopallidal.

• Reseptor D2 memediasi efek inhibitori pada jalur tidak langsung striatopallidal.

Page 4: Patofisiologi Parkinson 31 March

Allan RH, Samuels MA, editors. Adams and Victor’s Principles of Neurology. 9th ed. New York: McGraw Hill; 2009.pp 61-77)

Page 5: Patofisiologi Parkinson 31 March

Allan RH, Samuels MA, editors. Adams and Victor’s Principles of Neurology. 9th ed. New York: McGraw Hill; 2009.pp 61-77)