Laporan Resmi Emulsi Iecoris

7/17/2019 Laporan Resmi Emulsi Iecoris

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LAPORAN RESMI

PRAKTIKUM TEKNOLOGI SEDIAAN CAIR – SEMI PADAT

SEMESTER II

PERCOBAAN PEMBUATAN SEDIAAN EMULSI OLEUM IECORIS

ASELII DENGAN EMULGATOR TWEEN 80 DAN SPAN 80

KELOMPOK 1 :

1. ASRINI A112002

2. MENIK MEGAWATI A1131006

3. NANDA MAPRILIA A1131008

DIPLOMA III FARMASI

AKADEMI FARMASI NUSAPUTERA

SEMARANG

TAHUN 2013/201

I. !UDUL PERCOBAAN :



PEMBUATAN SEDIAAN EMULSI OLEUM IECORIS ASELII

II. TU!UAN PERCOBAAN :

1. M"#$%&' (")*&&+ "#%,(* #*+-& *&+ O,"%# *"*( &((",**

2. M",&%&+ 4"+5%*&+ (")*&&+ "#%,(*

3. M"+57*'%+5 4"+5&%7 HLB '"7&)&4 ('&$*,*'&( "#%,(*

III. TIN!AUAN PUSTAKA

a. Pengertian Emulsi

M"+%%' FI I "#%,(* &)&,&7 (*('"# )%& 9&(" -&+5 (&,&7 (&'%

&*&++-& '")*(4"(* )&,&# &*&+ -&+5 ,&*+ )&,&# $"+'% '"'"(&+ "*,.

!*& #*+-& -&+5 #"%4&+ 9&(" '")*(4"(* )&+ ,&%'&+ &* #"%4&&+ 9&("

4"#$&;&(*('"# *+* )*("$%' "#%,(* #*+-& )&,&# &*. S"$&,*+-& *& &*

&'&% ,&%'&+ &* -&+5 #"%4&&+ 9&(" '")*(4"(* )&+ #*+-& &'&% $&7&+

("4"'* #*+-& #"%4&&+ 9&(" 4"#$&;& (*('"# *+* )*("$%' "#%,(* &*

)&,&# #*+-&. E#%,(* )&4&' )*('&$*,&+ )"+5&+ 4"+&#$&7&+ $&7&+

4"+5"#%,(* -&+5 #"+"5&7 &,"("+(* -&*'% 4"+-&'%&+ '"'"(&+ "*,

#"+&)* '"'"(&+ $"(& )&+ &7*+-& #"+&)* (&'% 9&(" '%+55&, -&+5

#"#*(&7. FI ") I 1<<= 7&, >

b. Komponen Emulsi

K#4+"+ )&* "#%,(* )&4&' )*5,+5&+ #"+&)* 2 #&&# -&*'% :

1. K#4+"+ )&(&

A)&,&7 $"7&+ 4"#$"+'% "#%,(* -&+5 7&%( '")&4&' )&,&# "#%,(*

'")** &'&(:

• F&(" )*(4"( / 9&(" *+'"+&, / 9&(" )*(+'*+%"

?&*'% @&' &* -&+5 '"$&5*$&5* #"+&)* $%'*&+ "*, " )&,&# @&'

&* ,&*+.

• F&(" +'*+%" / 9&(" "'"+&, / 9&(" ,%&

?&*'% @&' &* )&,&# "#%,(* -&+5 $"9%+5(* ("$&5&* $&7&+ )&(&

4"+)%%+5 )&* "#%,(* '"("$%'.

• E#%,5&'

A)&,&7 $&7&+ )&* "#%,(* -&+5 $"9%+5(* %+'% #"+('&$*,&+

"#%,(*.

2. K#4+"+ '&#$&7&+

B&7&+ '&#$&7&+ -&+5 ("*+5 )*'&#$&7&+ 4&)& "#%,(* %+'%

#"#4","7 7&(*, -&+5 ,"$*7 $&*. M*(&,+-& *5"+ (&4*(,*(

4"("&'*" 4"+5&;"' &+'*(*)&+.

P"("&'*" -&+5 )*5%+&&+ &+'&& ,&*+ #"'*, )&+ 44*, 4&&$"+ &(&#

$"+@&' &(&# ($&' 9"+, "(, )&+ ,$%'&+, $"+@&,+*%#

,*)& 9"+*, #"%* &("'&' )&+ ,&*+,&*+.



A+'*(*)&+ -&+5 )*5%+&&+ &+'&& ,&*+ &(&# &($&' L.'47",

&(&# (*'&' 44*, 5&,,&' &(&# 5&,,&'.

c. Tipe Emulsi

B")&(&&+ #&&# @&' &* -&+5 $"9%+5(* ("$&5&* 9&(" *+'"+&, &'&%4%+

"'"+&, #&& "#%,(* )*5,+5&+ #"+&)* 2 #&&# :1. E#%,(* '*4" O/W *, *+ ;&'"

A'&% )*("$%' %5& '*4" M/A #*+-& )&,&# &* &)&,&7 "#%,(* -&+5

'")** &'&( $%'*&+ #*+-& -&+5 '"("$& ")&,&# &*. M*+-& ("$&5&*

9&(" *+'"+&, )&+ &* ("$&5&* 9&(" "'"+&,.

2. E#%,(* '*4" W/O ;&'" *+ *,

A'&% )*("$%' %5& '*4" A/M &* )&,# #*+-& &)&,&7 "#%,(* -&+5

'")** &'&( $%'*&+ &* -&+5 '"("$& ")&,&# #*+-&. A* ("$&5&* 9&("

*+'"+&, 9)&+ #*+-& ("$&5&* 9&(" "'"+&,.

d. Tujuan Pemakaian Emulsi

E#%,(* )*$%&' %+'% )*4","7 (%&'% 4"4&&' -&+5 ('&$*, )&+ &'& )&*

&#4%&+ 2 &*&+ -&+5 (&,*+5 '*)& $*(& $"&#4%.

1. D*4"5%+&&+ ("$&5&* $&' )&,&# / 4" &,.

U#%#+-& "#%,(* '*4" O/W

2. D*4"5%+&&+ ("$&5&* $&' ,%&.

B*(& '*4" O/W &'&%4%+ W/O '"5&+'%+5 $&+-& 9&' #*(&,+-& (*9&'

@&'+-& &'&% "+*( "9" '"&4* -&+5 )*"7"+)&*.

e. Teori Terjadinya Emulsi

U+'% #"+5"'&7%* 4("( '"$"+'%+-& "#%,(* )*"+&, #&&# '"*

-&+5 #",*7&' 4("( '"&)*+-& "#%,(* )&* (%)%' 4&+)&+5 -&+5 $"$")&

$")& -&*'% :

1. T"* T"5&+5&+ P"#%&&+ (Surface Tension)

M,"%, #"#*,** )&-& '&* #"+&* &+'&& #,"%, -&+5 (""+*( -&+5

)*("$%' )&-& kohesi. S",&*+ *'% #,"%, %5& #"#*,** )&-& '&*

#"+&* &+'&& #,"%, -&+5 '*)& (""+*( -&+5 )*("$%' )&-& adhesi.

T"5&+5&+ -&+5 '"&)* 4&)& 4"#%&&+ )*+&#&&+ '"5&+5&+

4"#%&&+ (surface tension) )&+ '"5&+5&+ -&+5 '"&)* &+'&& )%&

&*&+ )*+&#&&+ '"5&+5&+ $*)&+5 $&'&( (interfacial tension).

S"#&*+ '*+55* 4"$")&&+ '"5&+5&+ -&+5 '"&)* 4&)& $*)&+5

#"+5&*$&'&+ &+'&& ")%& @&' &* *'% ("#&*+ (%(&7 %+'%

$"&#4%. D&,&# '"* *+* )*&'&&+ $&7;& 4"+&#$&7&+ "#%,5&'

&&+ #"+%%+&+ &'&%+ #"+57*,&+5&+ '"5&+5&+ -&+5 '"&)* 4&)&



$*)&+5 $&'&( ("7*+55& &+'&& ")%& @&' &* '"("$%' &&+ #%)&7

$"&#4%.

2. T"* O*"+'&(* B"+'% B&* O*"+'") W")5"

S"'*&4 #,"%, "#%,5&' )*$&5* #"+&)* )%& ",#4 -&*'% :

•

K",#4 7*)9*,* $&5*&+ )&* "#%,5&' -&+5 (%& 4&)& &*.• K",#4 ,*49*,* $&5*&+ -&+5 (%& 4&)& #*+-&.

M&(*+5#&(*+5 ",#4 &&+ $"5&$%+5 )"+5&+ @&' &* -&+5

)*(""+*( ",#4 7*)9*,* ")&,&# &* )&+ ",#4 ,*49*,

")&,&# #*+-&. D"+5&+ )"#**&+ "#%,5&' (",&7,&7 #"+&)*

'&,* 4"+5*&' &+'&& &* )&+ #*+-&. A+'&& ")%& ",#4

'"("$%' &&+ #"#$%&' (%&'% "("*#$&+5.

S"'*&4 "+*( "#%,5&' #"#*,** 7&5& "("*#$&+5&+ -&+5

$"(&+-& '*)& (&#&. H&5& "("*#$&+5&+ *'% )*"+&, )"+5&+

*('*,&7 HLB H-)47-, L*447-, B&,&+" -&*'% &+5& -&+5

#"+%+%&+ 4"$&+)*+5&+ &+'&& ",#4 ,*49*, )"+5&+

",#4 7*)9*,.

Semakin besar harga HLB berarti semakin banysuka pada air,

itu artinya emulgator tersebut lebih mudah larut dalam air dan

demikian sebaliknya.

T&$", H&5& HLB

HARGA HLB KEGUNAAN

1 – 3 A+'* F&#*+5 A5"+'

– 6 E#%,5&' '*4" W/O

> – < B&7&+ 4"#$&(&7 ;"''*+5 &5"+'

8 – 18 E#%,5&' '*4" O/W

13 – 1= D"'"5"+'

10 – 18 K",&%'&+ (,%$*,*@*+5 &5"+'

C&& P"7*'%+5&+ HLB

R%#%( I

K"'"&+5&+ : H&5& HLB -&+5 )*#*+'& HLB -&+5 )*$%'%7&+

A H&5& HLB '*+55*

A $ – HLB$ 100

HLB& – HLB$

B & 100 A



B H&5& HLB "+)&7

R%#%( II

K"'"&+5&+ : B B"&' "#%,5&'

R%#%( III C&& 4"("+'&(*

R%#%( I C&& A,*5&'*"

N*,&* HLB B"$"&4& S%9'&+

AT HLB AT HLB

T;""+ 20 16> S4&+ 20 86

T;""+ 0 1=6 S4&+ 60 >

T;""+ 80 1=0 S4&+ 80 =

T;""+ 60 1< A,&", 83 3>

T;""+ 8= 110 G# 80

T;""+ 6= 10= '*"'&+,&#*+ 120

3. T"* I+'"4&(*&, F*,#

B&7;& "#%,5&' &&+ )*("&4 4&)& $&'&( &+'&& &* )&+ #*+-&

("7*+55& '"$"+'% ,&4*(&+ 9*,# -&+5 &&+ #"#$%+5%( 4&'*", 9&("

)*(4"(.

U+'% #"#$"*&+ ('&$*,*'&( #&(*#%# 4&)& "#%,(* (-&&' "#%,5&'

-&+5 )*4&&* &)&,&7 :

• D&4&' #"#$"+'% ,&4*(&+ 9*,# -&+5 %&' '&4* ,%+&

• !%#,&7+-& %%4 %+'% #"+%'%4 ("#%& 4"#%&&+ 4&'*", 9&("

)*(4"(

• D&4&' #"#$"+'% ,&4*(&+ 9*,# )"+5&+ "4&' )&+ )&4&' #"+%'%4

("#%& 4"#%&&+ 4&'*", )"+5&+ ("5"&.

. T"* E,"'* D%$," L&-"

T"* *+* (",&7,&7 '*&4 4&'*", #*+-& )*,*+)%+5* ,"7 2 $"+'"+5

,&4*(&+ ,*('* -&+5 (&,*+5 $",&;&+&+. T"&)*+-& #%&'&+ ,*('*

)*("$&$&+ ,"7 (&,7 (&'% )&* "'*5& && )*$&;&7 *+* :

• T"&)*+-& *+*(&(* )&* #,"%, 4&)& 4"#%&&+ 4&'*",

• T"&)*+-& &$($(* ,"7 *+ 4&'*", )&* &*&+ ("*'&+-&

• T"&)*+-& 5"("&+ 4&'*", )"+5&+ &*&+ )*("*'&+-&

B1 HLB1 B2 HLB2 B &#4%&+ HLB &#4%&+



. Bahan Pengemulsi !Emulgator"

E#%,5&' &,&#

E#%,5&' -&+5 )*4","7 )&* &,&# '&+4& 4("( -&+5 %#*'.

D&4&' )*5,+5&+ #"+&)* '*5& 5,+5&+ -*'% :1. E#%,5&' &,&# )&* '%#$%7'%#$%7&+

M"%4&&+ "#%,5&' '*4" O/W 4"& '"7&)&4 ","',*' )&+

&,7, &)& '*+55* %5& )&4&' )*%(& $&'"*. O,"7 ("$&$ *'%

4&)& 4"#$%&'&+ "#%,(* )"+5&+ #"+55%+&&+ "#%,5&' *+*

7&%( (",&,% )*'&#$&7 $&7&+ 4"+5&;"'.

&. G# A&$ / PGA &+ D%*+ 1<= 7&, 63

S&+5&' $&* %+'% '*4" O/W )&+ %+'% $&' #*+%#.

B*,& '*)& )*&'&&+ ,&*+ #&& "#%,(* )"+5&+ 5# &&$

#"+55%+&&+ 5# &&$ ("$&+-& )&* %#,&7#*+-&+-&. U+'% #"#$%&' 4%( "#%,(* )*4",%&+ &*

1= $"&' 5#. S",&*+ *'% )*("$%'&+ :

L"#&,"#& 4&)&' : PGA (&#& $&+-& )"+5&+

,"#& 4&)&'.

M*+-& ,"#& : PGA $"&' #*+-& "%&,*

,"%# **+*

M*+-& &'(** : PGA (&#& $&+-& )"+5&+ #*+-&

&'(** &+ D%*+ 1<= 7&, 68 O,"%# I"*( A(",** F+&( 1<>87&, 21>

M"+55%+&&+ PGA 30 )&* $"&' #*+-&.

$. T&5&&+'7 &+ D%*+1<= 7&, 6<

E#%,5&' *+* 7&+-& $""& 4&)& 4'*#%# 4H = – 6.

T&5&&+'7 )*5"%( )"+5&+ &* -&+5 20 $&+-&+-&.

T&5&&+'7 $"9%+5(* ("$&5&* 4"+5"+'&, '*)& )&4&'

#"#$"+'% ,*) 4",*+)%+5.

. A5&&5& &+ D%*+ 1<= 7&, >1

E#%,5&' *+* %&+5 "9"'*9 &4&$*,& )*4&&* ("+)**&+. P&)&%#%#+-& @&' *+* )*'&#$&7&+ %+'% #"+&#$&7 *((*'&(

)&* "#%,(* )"+5&+ 5# &&$. B*&(&+-& )*5%+&&+ 1 – 2

). C7+)%(

". S&+5&' $&* %+'% "#%,(* #*+-& *&+ &"+& )&4&'

#"+%'%4 &(& )&* #*+-& '"("$%'. C&& #"#4"(*&4&+

+-& (&#& ("4"'* &5&.

9. E#%,5&' ,&*+

P"'*+ #"'*, (",%,(&&$(*#"'*, (",%,(& 1 – 2

2. E#%,5&' &,&# )&* 7";&+&. K%+*+5 '",%



K%+*+5 '",% #"+5&+)%+5 ,"*'*+ 5,+5&+ 4'"*+ / &(#

&#*+ )&+ ,"('", -&+5 ("#%&+-& )&4&' $"9%+5(*

("$&5&* "#%,5&'. M"%4&&+ "#%,5&' '*4" O/W. &' *+*

)&4&' #"+5"#%,(*&+ #*+-& ,"#& "#4&' &,* $"&'+-&

)&+ #*+-& #"+5%&4 )%& &,* $"&'+-&.

$. A)"4( ,&+&"

&' *+* #"%4&&+ "#%,5&' '*4" W/O )&+ $&+-&

)*5%+&&+ %+'% 4"#&&*&+ ,%&. D&,&# "&)&&+ "*+5

)&4&' #"+-"&4 &* 2 $"&'+-&.

3. E#%,5&' &,&# )&* '&+&7 #*+"&,

&. M&5+"(*%# A,%#%+*# S*,*&'/ ""5%#

&' *+* #"%4&&+ "#%,5&' '*4" O/W. S")&+5&+

4"#&&*&+ -&+5 ,&@*# &)&,&7 ("$&+-& 1 . E#%,(* *+*7%(%( %+'% 4"#&&*&+ ,%&.

$. B"+'+*'

T&+&7 ,*&' -&+5 '")** )&* ("+-&;& &,%#%+*%# (*,*&'-&+5

)&4&' #"+5&$($(*&+ ("%#,&7 $"(& &* ("7*+55&

#"#$"+'% #&((& ("4"'* 5",. P"#&&*&+ %+'% "#%,5&'

("$&+-& =

. E#%,5&' B%&'&+

&. S&$%+ &+ D%*+ 1<= 7&, >0

S&+5&' $&+-& )*4&&* %+'% '%%&+ ,%&. D&4&' )*5%+&&+

("$&5&* "#%,5&' '*4" O/W #&%4%+ '*4" W/O ("(%&*

&,"+(*+-&. S&$%+ &,*%# $"&,"+(* 1 )*5%+&&+ %+'%

"#%,5&' '*4" O/W (")&+5&+ (&$%+ &,(*%# $"&,"+(* 2

#"%4&&+ "#%,5&' '*4" W/O.

$. T;""+ 20 : 0 : 60 : 80

. S4&+ 20 : 0 : 80

E#%,5&' )&4&' )*",#4&+ #"+&)* :

A+*+* : (&$%+ &,&,* +&'*%# ,&%-, (%,9&' K&'*+* : ("+-&;& &##+*%# %&'"+"

N+ *+* : ';""+ )&+ (4&+

A#9'" : 4'"*+ ,"*'*+

g. #ara Pembuatan Emulsi

D*"+&, 3 #"')" )&,&# 4"#$%&'&+ "#%,(* -&*'% :

1. M"')" 5# "*+5 &'&% #"')"+ +'*+"+'&,

D&,&# #"')" *+* @&' 4"+5"#%,(* $*&(&+- 5# &&+

)*&#4% )"+5&+ #*+-& '","$*7 )&7%,% "#%)*&+ )*



'&#$&7 &* %+'% 4"#$"+'%&+ 4%( "#%,(* $&%

)*"+"&+.

2. M"')" 5# $&(&7 &'&% #"')" *+55*(

&' 4"+5"#%,(* )*'&#$&+ ")&,&# &* @&' 4"+5"#%,(*

%#%#+-& ,&%' &5& #"#$"+'% (%&'% #%*,&5

"#%)*&+ 4",&7&+,&7&+ #*+-& )*&#4%&+ %+'%

#"#$"+'% "#%,(* ("'",&7 *'% $&% )*"+"&+.

3. M"')" $', &'&% #"')" $', 9$"(

D*5%+&&+ %+'% #*+-& #"+5%&4 )&+ @&'@&' -&+5

$"(*9&' #*+-& )&+ #"#4%+-&* *((*'&( "+)&7

%&+5 "+'&,. S"$% 5# )*#&(%&+ )&,&# $',

"*+5 "#%)*&+ )*'&#$&7&+ 2 $&5*&+ &* '%'%4 $',

"#%)*&+ &#4%&+ '"("$%' )* %&'. T&#$&7&+

&* (")**' )"#* (")**' (&#$*, )*.

h. #ara $embedakan Tipe Emulsi

1. D"+5&+ 4"+5"+"&+ 9&("

S"'*&4 "#%,(* )&4&' )*"+"&+ )"+5&+ 9&("

"('"+&,+-&.

2. D"+5&+ 4"+5"&'&+ / 4"#$"*&+ ;&+&

&' ;&+& &&+ '"("$& &'& )&,&# "#%,(* &4&$*,& @&'

'"("$%',&%' )&,&# 9&(" "('"+&,+-& )&* "#%,(*

'"("$%'. D*,*7&' )*$&;&7 #*(4.

E#%,(* ,&%'&+ S%)&+ III )&4&' #"#$"* ;&+& #"&7

4&)& "#%,(* '*4" W/O

E#%,(* ,&%'&+ M"'*,"+ B,%" )&4&' #"#$"* ;&+&

$*% 4&)& "#%,(* '*4" O/W

3. D"+5&+ "'&( (&*+5

B*,& "#%,(* )*'"'"(&+ 4&)& "'&( (&*+5 "'&( (&*+5

#"+&)* $&(&7 #&& '*4" O/W )&+ &4&$*,& '*#$%, +)&

#*+-& 4&)& "'&( $"&'* "#%,(* '*4" W/O

. D"+5&+ +)%'**'&( ,*('*

A,&' -&+5 )*4&&* &)&,&7 &;&' )&+ ('4 +'& )&+

,&#4% +"+ J ;&'' )*7%$%+5&+ ("&& ("*. L&#4%

+"+ &&+ #"+-&,& $*,& ","')& )*",%4&+ )&,&#

"#%,(* '*4" O/W)&+ &&+ #&'* &4&$*,& )*",%4&+

)&,&# "#%,(* '*4" W/O.

i. Kestabilan Emulsi



E#%,(* )*&'&&+ '*)& ('&$*, &4&$*,& #"+5&,&#* 3 7&,7&,

("4"'* :

1. C"&#*+5

?&*'% '"4*(&7+-& "#%,(* #"+&)* 2 ,&4*(&+ )*#&+&

-&+5 (&'% #"+5&+)%+5 9&(" )*(4"( ,"$*7 $&+-& )&*

,&4*(&+ -&+5 ,&*++-&. B"(*9&' reversible, $*(& )*5

4",&7&+ )&+ &&+ '")*(4"(* "#$&,*.

2. K&,"("+ )&+ &*+5 $"&*+5

A)&,&7 4"&7+-& "#%,(* &"+& 9*,# -&+5 #",*4%'*

4&'*", %(& )&+ $%'* #*+-& &&+ &,"("+

#"+-&'%. B"(*9&' irreversible '*)& $*(& )*4"$&**.

H&, *+* )*&"+&&+ :

&. P"*('*;& *#*& 4"+&#$&7&+ &,7, 4"%$&7&+ 4H

$. P"*('*;& 9*(*& ("4"'* 4"#&+&(&+ 4"+-&*+5&+

4"+)*+5*+&+ 4"+5&)%&+.

3. I+"(*

A)&,&7 4"*('*;& 4"%$&7&+ ("&& '*$&'*$& (%'*4"

"#%,(* O/W #"+&)* W/O &'&%4%+ ("$&,*+-&. B"(*9&'

irreversible.

I. TIN!AUAN BAHAN1. O,"%# I"*( A(",** FI ") I 1<<= 7&, 628

P"#"*&+ : C&*&+ #*+-& "+" $"$&% 7&( '*)& '"+5* &( )&+ $&%

("4"'* *&+.

K",&%'&+ : S%& ,&%' )&,&# "'&+, #%)&7 ,&%' )&,&# "'" )&,&#

,9# )&,&# &$+)*(%,9*)& )&+ )&,&# "'*, &("'&'.

K"5%+&&+ : P"+&#$&7 +&9% #&&+ #"#4""4&' "5"+"&(* (",

D(*( : 3 6<> 5/1= #, F#%,&*%# N&(*+&, 1<>8 7&, 21>

2. T;""+ 80 FI ") I 1<<= 7&, 68>

P"#"*&+ : &*&+ ("4"'* #*+-& "+*7 $";&+& %+*+5 #%)& 7%+55&

,&' #%)& $&% 7&( ,"#&7 &(& 4&7*' )&+ 7&+5&'.

K",&%'&+ : S&+5&' #%)&7 ,&%' )&,&# &* ,&%'&+ '*)& $"$&% )&+ 4&'*(

'*)& $";&+&. L&%' )&,&# "'&+, )&,&# "'*, &("'&' '*)& ,&%'

)&,&# #*+-& #*+"&,.

K"5%+&&+ : E#%,5&' 1 – 10 '*4" &*

3. S4&+ 80 M&'*+)&," =>>

P"#"*&+ : C&*&+ "+'&, $";&+& %+*+5

K",&%'&+ : P&'*( '*)& ,&%' '"'&4* '")*(4"(* )&,&# &* )&4&'

$"&#4% )"+5&+ &,7, (")**' ,&%' )&,&# #*+-& &4&(.

K"5%+&&+ : E#%,5&' 1 – 10 '*4" #*+-&

. G,*(", FI ") I 1<<= 7&, 13



P"#"*&+ : C&*&+ "+*7 ("4"'* (-%4 '*)& $";&+& &(& #&+*( 7&+-&

$,"7 $"$&% 7&( ,"#&7 '&&# &'&% '*)& "+& 7*5(4*(

+"'&, )"+5&+ ,&#%(.

K",&%'&+ : )&4&' $"&#4% )"+5&+ &* )&+ )"+5&+ "'&+, '*)& ,&%'

)&,&# ,9# )&,&# "'" )&+ )&,&# #*+-& ,"#& )&+

)&,&# #*+-& #"+5%&4.

K"5%+&&+ : A+'*#*$& 4"("&'*" "#,*"+' 4",&%' 30

HBE 200< 7&, 28

=. S$*', FI ") I 1<<= 7&, >=6

P"#"*&+ : ("$% 5&+%, 7*5(4*( ;&+& 4%'*7 &(& #&+*(

K",&%'&+ : S&+5&' #%)&7 ,&%' )&,&# &* (%& ,&%' )&,&# "'&+,

K"5%+&&+ : S;""'*+5 &5"+' &, (,%'*+ 20 – 3= HBE200<7&, 6><

. FORMULASI

I. ALAT DAN BAHAN

ALAT BAHAN

B"" 5,&(( O,"%# I"*( A(",**

T"##"'" T;""+ 80

C&;&+ P"(","+ S4&+ 80

B,"+)" G,*(",

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II. PERHITUNGAN DOSIS DAN !UMLAH BAHAN

T&$", )(*( 4"#&&*&+ 1 6<>5/1=#,

U#% D(*( R&+5" D(*( P"#&&*&+ / C C" D(*(

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/ 12 6<> 5 1>3 1

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R/ O,"%# I"*( A(",** 3=5/1=#,

T;""+ 80 6

S4&+ 80

G,*(", 28

S$*', 30

E(("+" FDC .(.

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> > / >12 6<> 5 2=68 068

8 8 / 812 6<> 5 2>88 063

< < / 20 6<> 5 313> 086

10 10 / 20 6<> 5 38= 0>=

11 11 / 20 6<> 5 383 1 0<1

12 12 / 20 6<> 5 182 1 08313 13 / 20 6<> 5 =31 1 0<6

T&$", )(*( 4"#&&*&+ 1 7&* 3 6<>5/1=#,

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2 2 / 212 20.<1 5 2<8> 3 J 088

3 3 / 312 20<1 5 182 3 1/3 083

/ 12 20<1 5 =228 3 1

= = / =12 20<1 5 61=0 3 08=

6 6 / 612 20<1 5 6<>0 3 0>=> > / >12 20<1 5 >>0 3 068

8 8 / 812 20<1 5 836 3 063

< < / 20 20<1 5 <10 3 086

10 10 / 20 20<1 5 10== 3 0>=

11 11 / 20 20<1 5 11=01 3 1 0<1

12 12 / 20 20.<1 5 12=6 3 1 083

13 13 / 20 20<1 5 13=<2 3 1 0<6

T&$", 4"7*'%+5&+ %#,&7 $&7&+

N

.

N&#& B&7&+ P"7*'%+5&+ B&7&+ P"+*#$&+5&+ B&7&+

1 O,"%# I"*( 3=5/1=#, 3= 5 3= 5

2 T;""+ 80 6 < 5 8<83 5

3 S4&+ 80 6 5 6 5

G,*(", 28 2 5 2 5

= S$*', 30 = 5 8<= 5

6 E(("+" FDC .(. .(.

> A%&)"(' A) 1=0 #, A) 1=0 #,

III. SKEMA KER!A

S*&4&+ &,&' )&+ $&7&+ 4&+&(&+ &*

K&,*$&(* $', 1=0 #,

R"+)&# #'*" )&+ ('&#4" )"+5&+ &* -&+5 (%)&7 )*4&+&(&+

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