Post on 16-Jul-2015
INH
ALA
LEBIH
JAU
H
Dr Salim S Thalib
INH
ALA
SI
OBAT MEL. SAL. NAPAS
BENTUK AEROSOL
TUJUAN TERAPI
LOKAL DAN SISTEMIK
DEFINISI
INH
ALA
SI
MANFAAT
DOSIS RENDAH
EFEK SAMPING MINIMAL
ONSET CEPAT
INH
ALA
SI
INH
ALA
SI
TINGGI
RENDAH
INH
ALA
SI
LAMA
MINIMAL
KHASIAT OBAT
EFEK SISTEMIK
PENYERAPAN ORAL
PLASMA PROTEIN
INH
ALA
SI
DEPOSISI AEROSOL
IMPACTION
PADA PARU
SEDIMANTATIONDIFFUSION
INH
ALA
SI
IMPACTION
INH
ALA
SI
IMPACTION SEDIMANTATION
INH
ALA
SI
DIFFUSION
INH
ALA
SI
DEPOSISI AEROSOLPADA PARU
NASOPHARENGEAL
IMPACTION
TRACHEOBRONCHIAL
IMPACTION
(CENTRAL)
SEDIMANTATION
PULMONARY
SEDIMANTATIONDIFFUSION
(PERIPHERAL)
INH
ALA
SI
UKURAN AEROSOL
MEDIAN DIAMETER-MICROMETERMASS MEDIAN DIAMETER-
MICROMETER
DEP
OS
ITIO
NFR
AC
TIO
N
INH
ALA
SI
KECEPATAN AEROSOL
TEND TO GET
TEND TO SLOWER FLOW
DEPOSITED IN UPPER AIRWAY
MINIMIZED UPPER AIRWAY
ENHANCHES DISTAL DELIVERY
HIGH VELOCITY
LOW VELOCITY
DEPOSITION
DEPOSITION
DEPOSITION
INH
ALA
SI
TIPE PERNAPASAN
BREATH HOLD AT END INSPIRATION
INCREASED CENTRALRAPID INHALATION
SLOW INHALATION
INCREASED PERIPHERAL
INH
ALA
SI ABSORPTION
ABSORPTION
TIPE PERNAPASAN
LOW SYSTEMIC
IMPACTIONVASCULER BED
HIGH SYSTEMIC
HUMIDIFICATIONNASAL BREATHING
MOUTH BREATHING
INH
ALA
SI
PENETRASI OBAT
SMALL AIRWAY MORE DEPOSITION
NARROWING AIRWAY :
VARIASI NORMAL JALAN NAPAS
PENYAKIT DASAR PARU
KED
ALA
M P
AR
U
BRONCHOSPAM, FIBROTIC, SECRETMORE DEPOSITION IN CENTRAL
Martonen TK , Pharm Respir 1995, 12: 96
IN CENTRAL
INH
ALA
SI
PENETRASI OBATK
EDA
LAM
PA
RU
ADULT CHILD CHILD WITHINFLAMED AIRWAY
INH
ALA
SI
FACTORS AFFECTING DELIVERY
OF AEROSOLIZED TO THE LUNG
FAC
TO
RS
AFFEC
TIN
G D
ELIVER
Y
INH
ALA
SI
HASIL TERAPI MELALUI
EFEK TOPIKAL
PROSES
ABSORBSIGABUNGAN
INH
ALA
SI
H.derendorf, Eur J 2006 ; 28 1042-1050
On site activation in the lung. low oropharyngeal exposure. Negligible oral bioavallability. protein binding and rapid
clearance
Decrease local and
systemic side effects
small particle High receptor binding activity. long pulmonary residence
time.Lipid conjugation.
Increase or prolong the anti
inflammatory effects
PHARMACOKINETIC PHARMACODYNAMIC
EFEK SAMPING INH
ALA
SI APAKAH ADA
TERAPI
INH
ALA
SI
POTENTIAL LOCAL
INH
ALA
SIc
POTENTIAL SYSTEMIC
SKIN BRUISING
INH
ALA
SI
PERANAN TERAPI
INHALASI PENYAKIT PARU
PER
AN
AN
TER
AP
I INH
ALA
SI P
AD
A P
ENYA
KIT
PA
RU
PCP
P
INH
ALA
SI
METERED DOSE PRESSURIZED
INHALERS
DDRY POWDERINHALERS
NNEBULIZERJET & ULTRA SONIC
PMETERED DOSE INHALERS
PRESSURIZED
INH
ALA
SI
PMETERED DOSE INHALERS
INH
ALA
SI
PRESSURIZED
PMETERED DOSE INHALERS
INH
ALA
SI
PRESSURIZED
PROPELLANTS
FORMULATION ACTUATOR
CONTAINER
METERING VALVE
PMETERED DOSE INHALERS CONTAINER
PRESSURIZED
PMETERED DOSE INHALERS PROPELLANTS
PRESSURIZED
PMETERED DOSE INHALERS ACTUATOR
PRESSURIZED
PMETERED DOSE INHALERS How to use
PRESSURIZED
PMETERED DOSE INHALERS
ADVANTAGES DISADVANTAGES
PRESSURIZED
PMETERED DOSE INHALERS
SPACER DEVICES
PRESSURIZED
PMETERED DOSE INHALERS
SPACER DEVICES
PRESSURIZED
INH
ALA
SI
PMETERED DOSE INHALERS
SPACER DEVICES
PRESSURIZED
EFFECT OF DIAMETER AND SPACER LENGTHON AVAILABILITY OF DRUG
INH
ALA
SI
WHY USE A WITH AN INHALER
INHALER ALONE, INHALER WITH SPACER,
MEDICINE ENDS UP IN MORE MEDICINE ISTHE MOUTH,
THROAT,STOMACH AND DELIVERED TO THE
DEVICES
PMETERED DOSE INHALERS
SPACER DEVICES
3 CATEGORIES :
SIMPLE TUBE HOLDING CHAMBER
RESERVE - FLOW
PRESSURIZED
PMETERED DOSE INHALERS
SIMPLE TUBE
SIMPLE TUBE EXTENTION
PRESSURIZED
TO ACTUATOR
SPACER
MOUTHPIECE
PMETERED DOSE INHALERS
VALVE HOLDING PRESSURIZED
CHAMBER
PMETERED DOSE INHALERS
VALVE HOLDING PRESSURIZED
CHAMBER
PMETERED DOSE INHALERS How to use
PRESSURIZED WITH SPACER
P- MDI WITH SPACER
RESERVE FLOWDEVICES
PMETERED DOSE INHALERS
PRESSURIZED
INH
ALA
SI
INHALERS FOR CHILDREN
INH
ALA
SI
DRY POWDER INHALERS
INH
ALA
SI
DRY POWDER INHALERS
PORTABLE INSPIRATORY FLOW-DRIVEN DEVICES THAT DELIVER POWDER FORMULATIONS OFINHALED DRUG TO LUNG
INH
ALA
SI
DRY POWDER INHALERS
INH
ALA
SI
DRY POWDER INHALERS
PRINCIPLES OF DRY POWDER INHALER DESIGN
INH
ALA
SI
DRY POWDER INHALERS
TU
RB
O H
ALE
R
INH
ALA
SI
DRY POWDER INHALERS
PERBANDINGAN DEPOSISI OBAT
P-MDI 15 % DPI 32 % Thorsson et al, 1998
INH
ALA
SI
DRY POWDER INHALERS
INH
ALA
SI
INH
ALA
SI
DRY POWDER INHALERS
INH
ALA
SI
DRY POWDER INHALERS
INH
ALA
SI
DRY POWDER INHALERS
INH
ALA
SI
DRY POWDER INHALERS
INH
ALA
SI
DRY POWDER INHALERS
INH
ALA
SI
DRY POWDER INHALERS
INH
ALA
SI
DRY POWDER INHALERS
INH
ALA
SI
DRY POWDER INHALERS
INH
ALA
SI
DRY POWDER INHALERS
INH
ALA
SI
NEBULIZER
INH
ALA
SI
NEBULIZER
INH
ALA
SI
JET -NEBULIZER
INH
ALA
SI
JET -NEBULIZER
INH
ALA
SI
ULTRA SONIC -NEBULIZER
INH
ALA
SI
ULTRA SONIC -NEBULIZER
INH
ALA
SI
MIST INHALER
CHARACTERISTIC OF THE
AEROSOL GENERATORS
•KARAKTERISTIK INH
ALA
SI ID
EAL
OBAT
BIAYA TERAPI YANG EKONOMIS
DEPOSISI OROPHARYNX RENDAH
DEPOSISI PARU TINGGI
NYAMAN, KOORDINASI MINIMAL
INH
ALA
KE ALI LEBIH
JAU
H
Dr Salim S Thalib