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Maftuchah Rochmanti, dr., M.Kes
DEPARTEMEN FARMAKOLOGI FK NAIR
MFT12GITFKMUA
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O!AT LOKAL
"ALRAN #ERNA $GIT%
O!AT PEN&AKIT TKAK'PEPTIK
ANTIEMETIK
PEN#A(AR ) LA*ANT ANTIDIARE
MFT12GITFKMUA
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O!AT PEN&AKIT TKAK'PEPTIK
ANTA"ID
ANTI"EKRE"I A"AM LAM!NG AGEN &ANG MELINDNGI MKO"A
ANTI!IOTIK
MFT12GITFKMUA
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PEN&AKIT TKAK'PEPTIK
+us Pe-tium $Tua +amun/
dan Tua duodenum%
Ref+us /astroesofa/us $GERD 0
Gastroeso-ha/ea+ Ref+u1 Disease% "tress're+ated /astritis
MFT12GITFKMUA
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PEN&E!A! LK" PEPTIKM
Asam +amun/ 2 -e-ti 3an/ tin//i
Iritasi
"u-+ai darah 3an/ uru
"eresi muus 3an/ uru
Infesi $!ateri (e+icoacter -3+ori%
MFT12GITFKMUA
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ANTA"ID
MFT12GITFKMUA
!asa +emah 3an/ ereasi den/an
asam hidro+orida +amun/ untu
mementu /aram dan air
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4.. ANTA"ID
Antasid meru-aan uffer ion hidro/en 5
Men/uran/i easaman +amun/
Pe-sin tida atif da+am +arutan -( diatas 6,7
men/hi+an/an n3eri -erut -ada tua -e-ti
MFT12GITFKMUA
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Efe "am-in/ 5
Natrium icaronate5
A+a+osis sistemi, retensi cairan #a+cium caronate5
(i-era+semia, nefro+itiasis
A+uminium hidro1ide5 Konsti-asi
Ma/nesium hidro1ide5 Diare
4.. ANTA"ID
MFT12GITFKMUA
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MFT12GITFKMUA
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#imetidine, Ranitidine, Famotidine, Ni9atidine
Menurunan seresi asam +amun/ = >7?
-ada -emerian dosis tun//a+, terutama
sesaat see+um tidur
Tera-i -eme+iharaan5
mence/ah eamuhan, terutama i+a
terda-at miroa (e+icoacter -3+ori
ANTAGONI" RE"EPTOR (8
MFT12GITFKMUA
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(Modified and reproduced, with permission, from Danilewith M et al:
Ranitidine suppression of gastric hypersecretion resistant to cimetidine.
N Engl J Med 1!"#$%&:"%.'
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4.. #IMETIDINE
Mem-un3ai cincin imida9o+e den/an
modifiasi rantai c3ano/uanidine
EFEK "AMPING5
' Diare, mua+, muntah atau ecemasan
' Granu+osito-enia, tromosito-enia,
dan -ansito-enia
' Gineomastia $-ada -emaaian
an/a +ama dan dosis tin//i%
MFT12GITFKMUA
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4.. RANITIDINE
Mem-un3ai cincin furan
EFEK "AMPING5
' Diare, mua+, muntah atau
ecemasan
' #ardiac arrh3tmia $-emerian i:%
' Anicteric drug induced hepatitis
MFT12GITFKMUA
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FAMOTIDINE
FARMAKOKINETIK
Per ora+5 asorsi ai OOA5 am
DOA5 7 B 8 am
E+iminasi5 /ina+ $@ B C7?%
MFT12GITFKMUA
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4.. FAMOTIDINE
Mem-un3ai strutur thia9o+e
EFEK "AMPING5
' Diare
' Mua+, muntah' Kecemasan
MFT12GITFKMUA
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NIHATIDINE
FARMAKOKINETIK
Per ora+5 asorsi >7 ?
#ma15 7,@ ' am
DOA5 7 am
E+iminasi5 /ina+ $>7?%
T 0 B 8 amMFT12GITFKMUA
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4.. NIHATIDINE
Potensi5
8 1 +eih uat dari #imetidine
Mem-un3ai strutur thia9o+e
EFEK "AMPING5
' Diare, mua+, muntah
' Kecemasan
MFT12GITFKMUA
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AGEN ANTIM"KARINIK
PIRENHEPINE
Re+atif se+etif untu rese-tor
musarini
MFT12GITFKMUA
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OMEPRAHOLE
Menurunan seresi asam +amun/
Mem-un3ai efe antimiroa terhada-
(e+icoacter -3+ori
FARMAKOKINETIK
"uasana asam5 inatif dierian sea/ai
ta+et sa+ut enteri
Asorsi5 usus ha+us -ada -( asa $'6 am%
DOA5 = hari
MFT12GITFKMUA
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4.. OMEPRAHOLE
INDIKA"I5
Tua +amun/
Esofa/itis
"indroma Ho++in/er'E++ison
EFEK "AMPING5
(i-er/astrinemia $-ada -en//unaan
an/a -anan/%
#a Gaster teradi -ada tius -ercoaan,
teta-i tida -ada mencit atau manusia
MFT12GITFKMUA
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LAN"OPRAHOLE
Menurunan seresi asam +amun/
Pun3a efe antimiroa terhada- (. -3+ori
FARMAKOKINETIK
"uasana asam 5inatif dierian sea/ai
ta+et sa+ut enteri
T 0 ,@ am, teta-i da-at men/hamat
asam +amun/ 8 ' 6 hari
MFT12GITFKMUA
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4.. LAN"OPRAHOLE
INDIKA"I
Tua +amun/
Esofa/itis
Tua duodenum
EFEK "AMPING
(i-er/astrinemia $-ada -en//unaan
an/a -anan/%
#a Gaster teradi -ada tius -ercoaan,
teta-i tida -ada mencit atau manusiaMFT12GITFKMUA
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AGEN &ANG
MELINDNGI MKO"A
"#RALFATE
"EN&AA !I"MT( KOLOID
#AR!ENO*OLONE
PRO"TAGLANDINE
MFT12GITFKMUA
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"#RALFATE
A+uminum sucrose su+fate
!eera sea/ai saar terhada- (#+
Men/uran/i ati:itas -e-sin dan
menin/atan -rosta/+andin arin/an
MFT12GITFKMUA
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4.. "#RALFATE
FARMAKOKINETIK
Asorsi dari GIT5 san/at sediit
Pen/atifan oat diutuhan suasana
asam -emerian ersama A(8 atau
antasid da-at menurunan
ioa:ai+ai+itasMFT12GITFKMUA
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4.. "#RALFATE
INTERAK"I O!AT
Men/hamat asorsi Tetrasi+in,
arfarin, Fenitoin, Di/osin,
"i-rof+osasin dan Norf+osasin
dierian den/an inter:a+ 8 am
MFT12GITFKMUA
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4.. "#RALFATE
INDIKA"I5 ' Tua +amun/
' Tua duodenum
KONTRA INDIKA"I5
' Ga/a+ /ina+
EFEK "AMPING5
' Konsti-asi $6,C? -asien%
MFT12GITFKMUA
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"EN&AA !I"MT( KOLOID
Dicitrate ismuthate dan !ismuth
susa+ic3+ate
"aar muosa +amun/ terhada-
asam
Memunuh (. -3+ori
MFT12GITFKMUA
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PRO"TAGLANDINE
Prosta/+andin E $Miso-rosto+%
"timu+asi seresi muus daniaronat o+eh muosa /aster
Men/uran/i resio teradin3a
u+serasi da+am -en//unaan N"AID
MFT12GITFKMUA
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4.. PRO"TAGLANDINE
FARMAKOKINETIK
Asorsi ce-at dan dihidro+isis
menadi entu atif
Metao+isme5 +i:er E+iminasi5 /ina+
EFEK "AMPING5
' N3eri adomina+, diare
' Kontrasi uterus men/ontro+
-erdarahan -ost -artum
MFT12GITFKMUA
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ANTI!IOTIK
Di/unaan -ada Tua -e-ti ronis
3an/ diseaan o+eh (. -3+ori
Oat -i+ihan5
Proton Pum- Inhiitor, atau
"en3aa !ismuth Ko+oid, atau
Tetrac3c+ine, Metronida9o+e,
Amo1ici++in dan #+arithrom3cin
MFT12GITFKMUA
ANTIEMETIK
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ANTIEMETIK
MFT12GITFKMUA
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4.. ANTIEMETIK
Antihistamine ( 5 D3-henh3dramine,
Dimenh3drinate
Efetif men/atasi mua+ muntah arena mau
-era+anan $de-resi a+ur :estiu+oseree+um%
Phenothia9ine $Proch+or-era9ine,
Prometha9ine%, Dro-erido+
Meru-aan anta/onis rese-tor do-aminMFT12GITFKMUA
ANTIEMETIK
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4.. ANTIEMETIK
Metoc+o-ramide
Meru-aan anta/onis rese-tor do-amine
$D8 rece-tor anta/onist%
Efetif men/atasi mua+ muntah -ada-en//unaan oat antianer dan
mence/ah mua+ muntah sete+ah
di+auan anestesi umum
Da-at timu+ /ea+a -arinsonism, efe
estra-iramida+ dan hi-er-ro+atinemia
-ada -en//unaan an/a -anan/
MFT12GITFKMUA
ANTIEMETIK
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Ondansetron, Granisetron, Do+asetron
dan Pa+onosetron
Meru-aan anta/onis rese-tor serotonin
$@'(T rece-tor anta/onist%
Efetif men/atasi mua+ muntah -ada
-en//unaan oat antianer dan
mence/ah mua+ muntah sete+ahdi+auan anestesi umum
#orticosteroid5 De1amethasone
4.. ANTIEMETIK
MFT12GITFKMUA
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"co-o+amine5 Antimuscarinic dru/s
A-re-itant
Meru-aan anta/onis rese-tor neuroinin$NK 1 receptor antagonist %, 3aitu suatu
rese-tor di #N" 3an/ diati:asi o+eh
Substance P dan Tach3inin +ain Efetif men/atasi mua+ muntah -ada
-en//unaan oat antianer
4.. ANTIEMETIK
MFT12GITFKMUA
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PEN#A(AR
PEN#A(AR IRITAN ATA "TIMLTAN
PEN#A(AR &ANG MEMPER!E"AR
OLME I"I ""
PELNAK FE"E"
MFT12GITFKMUA
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MFT12GITFKMUA
PEN#A(AR IRITAN ATA "TIMLTAN
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PEN#A(AR IRITAN ATA "TIMLTAN
Min3a castor5
dihidro+isis da+am usus eci+ a/ian atas
menadi ricino+eic acid, suatu iritan +oa+
3an/ menin/atan moti+itas usus
#ascara, "enna dan A+oes5
men/andun/ a+a+oida emo+ien 3an/
meru-aan stimu+tan o+on
Pheno+-htha+ein dan !isacod3+
MFT12GITFKMUA
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PELNAK FE"E"
Meru-aan a/en'a/en 3an/ teremu+si
den/an feses, eera mem-er+una feses
Min3a minera+, su-osituria /+3serin dan
Dioct3+ sodium su+fosuccinate
MFT12GITFKMUA
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ANTIDIARE
AD"OR!ENT
OPIOID LARTAN RE(IDRA"I
MFT12GITFKMUA
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!ahan den/an area -ermuaan 3an/ +uas
Men/iat 9at 3an/ ereda termasu tosin,
den/an men/inati:asi dan men/e+iminasi
Kao+in -oder 2 "iat a+uminum hidrat, serin/
ominasi d/ Pectin, (am-ir tida
eraha3a 2 efetif -ada an3a asus
!ismuth susa+ic3+ate, men/iat ahan
tosin dan me+indun/i -ermuaan muosa
3an/ teriritasi
AD"OR!ENT
MFT12GITFKMUA
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LAM!NG
men/hamat seresi (#+, /era +amun/ ,
tonus otot , maanan +amat e duodenum
"" (AL"
ontrasi -ro-u+sif , tonus 2 s-asme
-eriodi
, asor-si air isi -adat
"" !E"AR /eraan -ro-u+si , tonus , s-asme usus
esar onsti-asi
OPIOID
MFT12GITFKMUA
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LARTAN RE(IDRA"I
G+uosa 3/ men/andun/ +arutan /aram
memudahan cairan diasor-si rn tosin
tida merusa cotrans-ort NaJ 2 /+uosa
me+a+ui muosa e-ite+
Tida men/hentian diare, ta-i dehidrasi
erhasi+ dice/ah
Na#+ ,@ G+uosa 87 Na(#O 8,@ K#+ ,@
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