Post on 21-Feb-2018
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A Trial of Combination Antimalarial
Therapies in Children from Papua NewGuinea
leh !"EL#I "ULI"TIA NING"I$
%onsulen !
Dr& Rini' "p&A' (&%es
SMF ANAK RS. DR. M. YUNUS BENGKULU
FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN
UNIVERSITAS BENGKULU
2015
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IDENTITA" JURNAL
Judul
A Trial of Combination Antimalarial Therapies inChildren from Papua New Guinea
Harin A. Karunajeewa, M.., .!., "#o Mueller, Ph.$., Mi%hele!enn, M.$., &nmoore 'in, Ph.$., "rwin 'aw, M.., .!., P. !er#ina
Gomorrai, $ip.Nurs., (li#e (a, H.&.(., !u)anne Gri*n,$ip.Nurs., Ka+e Kotab, $ip.Nurs., Penias !uano, .!%.Nurs.,Nandao Taron-a, Ali%e ra, $ul%ie 'autu, .!%., Madhu Pae/!harp, Ph.$., 0ina 1on, .!%., !am !alman, Peter !iba, Ph.$.,
Kenneth 2. "lett, Ph.$., and Timoth+ M.&. $a#is, $.Phil., M..,.!.
The New &nland Journal of Medi%inewas published at www.nejm.or
Desember )**+
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M&T($&
Desain Penelitian
Penelitian dimulai dari April 3445 6 Juli 3447
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PA!"&N
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Prosedur Klinis dan'aboratorium
ilaianKlinis
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Prosedur Klinis dan'aboratorium
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2ollow p Hari -e/83 ntu-Melihat &fe- Pemberian (bat
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Analisis !tatisti-
Kelompo-
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HA!"'
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PA!"&N
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f - i i l
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&fe-ti#itas MelawanPlasmodium falciparum
9 :;< ana- 6 ana- +an menalami
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P l i G t it i t b - t d t
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Pre#alensi Gametositemia terban+a- terdapatpada -elompo- Kloro-uin 6 !P =Ma-simum pada
hari -e/7 +aitu >
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&fe-ti#itas MelawanPlasmodium vivax
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(onitorin, %eamanan
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(onitorin, %eamananTida- ada penari-an obat +an disebab-an oleh efe- sampin
pada penelitian.
"nsidensi terjadin+a demam dan mutah antara hari 4 /7 padapenunaan -ombinasi artemisinin lebih rendahdibandin-an %loro-uin . "P=PB4.448. Tetapi untu- ejala
+an lain tida- ada perbedaan sini-an antar perbedaanpenobatan.
"nsidensi terjadin+a ruam lebih tini denan penunaaanArtesunate . "P dan Dih/droartemisinin0Pipera1uine
dibandin-an denan %loro-uin . "P =PB4.448
'impa serin teraba pada -elompo- Artemeter .Lumefentrine =PB4.44D
Kadar Hb sama pada -elompo- perla-uan, rata/ ratapenin-atan dihari -e /83 +aitu :,7 ;dl
Hipoli-emia tida- ada perbedaan sini-an di setiap ana-.
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$is-usi
ilaianKlinis
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C0"T"CA' APP0A"!A'
J(0NA'
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Judul
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Populasi di%antum-an
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PIC
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PIC
Patient
2)* oran, usia 3*-elompo- e4perimen
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PICInter5ention
Mela-u-an analisis statisti- data pasien untu-
menindeti-asi penanda bio-imia stres o-sidatif +aitu
pero-sidasi lipid +an ditandai denan tin-at TA0!
dan status antio-sidasi total +an ditandai denan
tin-at Eitamin & dan TAC.
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PICComparison ntu- membandin-an patoenesis -eter-aitan usia
dan -atara- diabeti- denan -atara- nu-lir dan -orti-aldenan -elompo- -ontrol pada lensa dan serum
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PIC
(ut%ome Pero-sidasi lipid +an ditandai denan TA0! se%ara
sini-an menin-at bai- dalam serum maupun lensapada -etia -elompo- -atara- dibandin-an denan-elompo- -ontrol
!tatus antio-sida total +an ditandai denan tin-at#itamin & dan TAC pada plasma dan lensa se%arasini-an menurun pada -etia -elompo- -atara-dibandin-an denan -elompo- -ontrol.
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TERI(A %A"I$