Patch Test Concentrations and Vehicles for Testing Contact ...

Patch testing is a relatively safe and reasonably reli-able method for identifying contact allergens in pa-tients with contact dermatitis. It has been clearlyshown that patch testing is necessary in the majorityof patients with eczema [1]. The technique of patchtesting is described in Chap. 22.

All patients are tested with the European standardseries, containing the most frequent contact allergensin European countries (Table 1). Often, standard se-ries patch testing is not enough, and additional aller-gens or potential allergens need to be tested, basedon the patient’s history and clinical examination. Ex-amples are products and chemicals to which the pa-tient is exposed occupationally or in his or her homeenvironment. Test series containing the most fre-quent allergens in certain products (preservatives,fragrances, dental materials, plastics and glues, me-dicaments) or in certain occupations (hairdressing,pesticides, oil and cooling fluid) are very helpful. Ap-proximately 510 patch test materials are commercial-ly available from Hermal (Reinbek, Germany, www.hermal.de), Chemotechnique Diagnostics (Malmö,Sweden, www.chemotechnique.se) and Brial Allergen(Greven, Germany, www.brial.com).

For other chemicals and products, the investigatormust decide how to apply them as a patch test. Chem-icals usually need to be diluted, and it is of the utmostimportance to use an appropriate patch test concen-tration and vehicle to avoid both false-negative andfalse-positive (irritant) reactions. The most usefulreference source for documented test concentrationsand vehicles of chemicals, groups of chemicals andproducts is the book Patch testing. Test concentra-tions and vehicles for 3700 chemicals [2]. Other usefullists are provided in recent textbooks on contact der-matitis [3–6].

Guidelines for testing the patient’s own contactmaterials are provided in Chap. 50.

Table 2 lists alphabetically all chemicals men-tioned in this book with their test concentrations andvehicles (sometimes two concentrations are suggest-ed when insufficient data are available) as suggestedby the various authors. All allergens commerciallyavailable are also listed with their supplier(s), theirtest concentrations, and vehicles as supplied. Itshould be appreciated that for a considerable num-ber of allergens, the concentrations vary betweensuppliers. Table 3 provides a list of test concentra-tions for groups of chemicals as suggested by variousauthors in this book. Table 4 finally is an alphabeticallisting of commonly used abbreviations and their fullchemical synonyms.

References

1. Rycroft RJG (1990) Is patch testing necessary? In:Champion RH, Pye RJ (eds) Recent advances in dermatol-ogy, vol 8. Churchill Livingstone, Edinburgh, pp 101–111

2. De Groot AC (1994) Patch testing. Test concentrations andvehicles for 3700 chemicals, 2nd edn. Elsevier, Amsterdam

3. Rietschel RL, Fowler JF Jr (eds) (1995) Fisher’s contact der-matitis, 4th edn. Williams and Wilkins, Baltimore, Md.

4. Adams RM (1990) Occupational skin disease, 2nd edn.Saunders, Philadelphia, Pa.

5. De Groot AC, Weijland JW, Nater JP (1994) Unwantedeffects of cosmetics and drugs used in dermatology, 3rdedn. Elsevier, Amsterdam

6. Kanerva L, Elsner P, Wahlberg JE, Maibach HI (eds) (2000)Handbook of occupational dermatology. Springer, BerlinHeidelberg New York

Chapter 49

Patch Test Concentrations and Vehicles for Testing Contact AllergensAnton C. De Groot, Peter J. Frosch

49

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Table 1. The European standard series

Chemical Test concentrationand vehicle

Metals Cobalt chloride 1% pet.Nickel sulfate 5% pet.Potassium dichromate 0.5% pet.

Rubber chemicals Thiuram mix 1% pet.Dipentamethylenethiuram disulfide (0.25%)Tetramethylthiuram disulfide (0.25%)Tetraethylthiuram disulfide (0.25%)Tetramethylthiuram monosulfide (0.25%)

N-Isopropyl-N´-phenyl-p-phenylenediamine 0.1% pet.Mercapto mix 2% pet.

N-Cyclohexylbenzothiazyl sulfenamide (0.5%)Dibenzothiazyl disulfide (0.5%)Mercaptobenzothiazole (0.5%)Morpholinyl mercaptobenzothiazole (0.5%)

Mercaptobenzothiazole 2% pet.

Medicaments Budesonide 0.01% pet.Benzocaine 5% pet.Neomycin sulfate 20% pet.Clioquinol® 5% pet.Tixocortol pivalate 0.1% pet.

Cosmetic ingredients Balsam of Peru (Myroxylon pereirae) 25% pet.5-Chloro-2-methylisothiazol-3-one/2-methylisothiazol-3-one (MCI/MI) 0.01% aq.Colophonium (rosin) 20% pet.Formaldehyde 1% aq.Fragrance mix (incl. 5% sorbitan sesquioleate) 8% pet.

α-Amylcinnamaldehyde (1%)Cinnamal(dehyde) (1%)Cinnamyl alcohol (1%)Eugenol (1%)Geraniol (1%)Hydroxycitronellal (1%)Iso-eugenol (1%)Oak moss absolute (Evernia prunastri) (1%)

Paraben mix 16% pet.Butylparaben (4%)Ethylparaben (4%)Methylparaben (4%)Propylparaben (4%)

p-Phenylenediamine free base 1% pet.Quaternium-15 1% pet.Wool wax alcohols (lanolin alcohol) 30% pet.Hydroxymethylpentylcyclohexenecarboxaldehyde (Lyral®) 5% pet.

Miscellaneous p-tert-Butylphenol formaldehyde resin 1% pet.Epoxy resin 1% pet.Primin 0.01% pet.Sesquiterpene lactone mix 0.1% pet.

Alantolactone (0.033%)Dehydrocostus lactone (0.033%)Costunolide (0.033%)

Anton C. De Groot, Peter J. Frosch908

49

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Table 2. Test concentrations, vehicles and commercial availability of contact allergens. [Alc. Alcohol, aq. water, DMSO dimethylsulfoxide, Glyc. glycerine, MEK methyl ethyl ketone (butanone), o.o. olive oil, pet. petrolatum, prop. glyc. propylene glycol.] [icrImmediate contact reactions reported (Chaps 5 and 26), de drug eruption with positive patch test reported (Chap. 24), fde fixeddrug eruption with positive patch test reported (Chap. 24), ph photosensitivity reported (Chaps 6, 17 and 27), phde photosensi-tive drug eruption with positive photopatch test reported (Chaps 6, 17, 24 and 27)]

Allergen Test Concentration and vehicle Suppliers

Trolab Chemo Brial

Abietic acid (icr) 10% pet. + + +Acebutolol hydrochloride 2% pet.Aceclofenac 1% petAcetylsalicylic acid (icr) 10% pet.Achillea millefolium (yarrow extract) 1% pet. + +Acid black 48 (CI 65005) 1% pet.Acid red 14 (azorubine) 0.1% alc.Acid red 118 (CI 26410) 5% pet. +Acid red 359 5% pet. +Acid violet 17 (CI 42650) 1% pet.Acid yellow 36 (CI 13065, metanil yellow) 1% pet. + + +Acid yellow 61 (CI 18968) 5% pet.Actarit (phde) 1% petAciclovir (fde) 5% pet.Alantolactone (icr) 0.33% pet.Alclometasone-17,21-dipropionate 1% alc. 1% pet.Alcohol, ethyl (icr) 10% aq.Alimemazine tartrate see Trimeprazine tartrateAllantoin 0.5% aq.Althiazide (phde) 10% pet. or aq.Aluminum (icr) PureAluminum chloride hexahydrate 2% pet.Allylisopropylacetylurea See ApronalideAmalgam 5% pet.Amalgam alloying metals 20% pet. + +Amalgam non gamma 2 5% pet.Amcinonide 1% alc. 0.1% pet. 0.1% pet.Amerchol ® L-101 See Lanolin alcohol and

paraffinum liquidumAmethocaine See Tetracaine hydrochlorideAmikacin sulfate 20% pet.4-Aminoantipyrine See Ampyronep-Aminoazobenzene (Solvent yellow 1, CI 11000) 0.25% pet 1% pet. + 1% pet.ε-Aminocaproic acid 1% aq.Amino-4-N, N-diethylaniline sulfate (TSS Agfa®) 1% pet.2-2-(Aminoethoxy)ethanol See DiglycolamineAmino-4-N-ethyl-N-(methanesulfon- 1% pet. + +aminoethyl)-m-toluidine (CD 3)Aminoglycosides (de) 20% pet.m-Aminophenol 1% pet. + + +p-Aminophenol (CI 76550) (icr) 1% pet. + + +Aminophylline (fde) 10% pet.Amitriptyline (phde) 5% pet.Amlexanox (fde) 1% pet.Ammoniated mercury 1% pet. + + +Ammonium bituminosulfonate See IchthammolAmmonium heptamolybdate 1% aq.Ammonium hexachloroplatinate (icr) 0.1% aq. +Ammonium persulfate (icr) 2.5% pet. + + +Ammonium tetrachloroplatinate (icr) 0.25% pet. + 0.25% aq. +Ammonium thioglycolate 1% pet., fresh 2.5% aq. 1% pet.Amorolfine 1% pet.Ampicillin (icr) 5% pet. +Ampiroxicam (phde) 1% pet.Amprolium hydrochloride 10% aq.Ampyrone (4-aminoantipyrine) (icr) 10% pet.

Chapter 49Patch Test Concentrations and Vehicles 909

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Table 2. Continued


Trolab Chemo Brial

α-Amylcinnamaldehyde (icr) 2% pet. 1% pet. + 1% pet.Amylocaine hydrochloride 5% pet +Anethole 5% pet.Aniline 1% pet. +Antazoline 1% pet.Anthemis nobilis (chamomilla romana) 1% pet.Antipyrine (phenazone) (de) 5% pet.Apronalide (allylisopropylacetylurea) (fed) 5% pet.Arnica montana (arnica extract) 0.5% pet. + +Arsanilic acid 10% pet.Atenolol (de) 10% pet.Atranorin (ph) 0.1% pet.Atropine sulfate 1% aq. or pet + (aq.) + (aq.)Azathioprine 1% pet.Azidamfenicol 2% pet.Azodicarbonamide 0.5% pet.Azodiisobutyrodinitrile 1% pet.Azorubine See Acid red 14Bacitracin (icr) 20% pet. + 5% pet. +Bacitracin zinc 20% pet.Balsam of Peru See Myroxylon pereiraeBalsam of Tolu See Myroxylon toluiferumBasic brown 1 See Bismarck Brown RBasic red 46 1% pet.Beech tar See Fagus sylvaticaBefunolol 1% aq.Benomyl 0.1–1% pet.Benoxinate See OxybuprocaineBenzaldehyde (icr) 5% pet. + +Benzalkonium chloride (BAK) 0.01–0.1% aq. 0.1% pet. 0.1% aq. 0.1% pet.Benzamine lactate 1% pet.2-Benzimidazolethiol 1% pet.

(2-mercaptobenzimidazole)Benzisothiazolinone (BIT) (ph) 0.1% pet. + 0.05% pet. +Benzocaine (icr) (ph) 5% pet. + + +Benzodiazepines (de) 1–5% aq. or pet.Benzoic acid (icr) (ph) 5% pet. 5% pet.; 1%

alc./glyc.Benzoin resin see Styrax benzoinBenzophenone-3 (oxybenzone) (ph) 10% pet. + + +Benzophenone-4 (sulisobenzone) (ph) (icr) 10% pet. + + +Benzophenone-10 (mexenone) (ph) 10% pet. +IH-Benzotriazole 1% pet. + + +Benzyl benzoate 5% pet.Benzoyl peroxide (icr) 1% pet. + + +Benzydamine hydrochloride (ph) 5% pet. or aq.Benzyl alcohol (icr) 1% pet. + + +Benzyl cinnamate 5% pet.Benzylhemiformal 1% pet.Benzyl salicylate 1–5% pet. 1% pet. 2% pet. 1% pet.Bergamot oil See Citrus bergamiaBeryllium chloride or sulfate 1% pet.Betamethasone dipropionate 1% alc.Betamethasone-17-valerate 1% alc. 0.12% pet. 1% pet. 0.12% pet.Betaxolol hydrochloride 1% aq.Betula alba (birch tar) 3% pet.BHA (butylated hydroxyanisole) (icr) 2% pet. + + +; 2% alc.BHT (butylated hydroxytoluene) (icr) 2% pet. + + +; 2% alc.Bifonazole 1% alc.


49

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Table 2. Continued


Trolab Chemo Brial

Bioban ® CS-1135 1% pet. + + +Bioban ® CS-1246 1% pet. + +Bioban® P 1487 1% pet. 0.5% pet. 1% pet.Biocheck 60 ® 0.2% aq.Bis(aminopropyl)-lauramine 0.01–0.1–1% aq.Bis(dibutyldithiocarbamato) zinc See Zinc dibutyldithiocarbamateBis(diethyldithiocarbamato) zinc See Zinc diethyldithiocarbamateBIS-EMA 1% pet. +BIS-GMA 2% pet. + + +BIS-MA 2% pet. +Bismarck Brown (vesuvine brown, 0.5% pet. + +

basic brown 1, CI 21000)Bismuth neodecanoate 1% pet.Bisphenol A See 4,4´-isopropylidenediphenolBisphenol A dimethacrylate 2% pet.Bithionol (ph) (icr) 1% pet. + + +Black rubber mix (N-isopropyl-N-phenyl-p- 0.25% pet.

phenylenediamine, N-cyclohexyl-N-phenyl-p-phenylenediamine, N, N-diphenyl-p-phenylenediamine)

Boric acid 10% pet.Brilliant black 0.1%

coca/glyc.Brilliant lake red R (D&C red 31, CI 15800) 1% pet.

(ph) (icr)5-Bromo-4´-chlorosalicylanilide (ph) 1% pet.2-Bromo-2-nitropropane-1,3-diol (icr) 0.5% pet. 0.25% pet. 0.5% pet.Budesonide 0.1% pet. + 0.01% pet. +Bucillamine (de) 1% pet.Bufexamac 5% pet. + +Bupivacaine 1% pet.Butacaine 5% pet.1,4-Butanediol diacrylate (BUDA) 0.1% pet. +1,4-Butanediol dimethacrylate (BUDMA) 2% pet. + +Butethamine hydrochloride 5% pet.Butyl acrylate (BA) 0.1% pet. + +Butyl aminobenzoate 5% pet.Butylated hydroxyanisole See BHAButylated hydroxytoluene see BHT4-tert-Butylbenzoic acid 1% pet.p-tert-Butylcatechol (PTBC) 0.25% pet + 1% pet.Butyl glycidyl ether 0.25% pet.t-Butyl hydroquinone 1% pet. + + +n-Butyl methacrylate (BMA) 2% pet. +Butyl methoxydibenzoylmethane (ph) 10% pet. + + +Butylparaben (icr) 3% pet. + + +p-tert-Butylphenol 1% pet. + + +p-tert-Butylphenolformaldehyde resin (PTBP) 1% pet. + + +Cadmium chloride (ph) 0.5% pet. 1% aq. +Caine mix I (procaine hydrochloride, 3.5% pet

dibucaine hydrochloride).Caine mix II (dibucaine hydrochloride, 10% pet.

lidocaine, tetracaine)Caine mix III (benzocaine, dibucaine, tetracaine) 10% petCaine mix IV (amylocaine, lidocaine, prilocaine) 10% petCalcipotriol 2 µg/ml alc.Camphor (icr) 1% pet.Camphoroquinone 1% pet.Cananga odorata (cananga oil, ylang-ylang oil) 5% pet. 2% pet.Captan 0.5% aq. or pet. 0.5% pet.


49_907_928 05.11.2005 12:13 Uhr Seite 911

Table 2. Continued


Trolab Chemo Brial

Captopril (de) 0.1–3% petCarbamazepine (de) (fde) (phde) 10% pet. or alc. / 0.01–10% pet.Carba mix (N, N-diphenylguanidine, 3% pet. 3% pet.

zinc dibutyl dithiocarbamate,zinc diethyldithiocarbamate)

Carbenicillin (de) 5% aq.Carprofen 5% pet.Carteolol 1% aq.Castor oil PureCD 2 (color developer 2) See Methyl-3-amino-4-N, N-

diethyl-anilineCD 3 (color developer 3) See Amino-4-N-ethyl-N-(methane-

sulfonaminoethyl)-m-toluidineCD 4 (color developer 4) See 4-(N-Ethyl-N-2-hydroxyethyl)-

2-methylphenylenediamine sulfate

Cedarwood oil See Cedrus atlanticaCedrus atlantica (cedarwood oil) (ph) 10% pet. + +Celecoxib (de) 10% pet.Cetalkonium chloride 0.1% pet. 0.1% pet.Cetrimide See Cetrimonium bromideCetrimonium bromide (Cetrimide) 0.25% pet.Cetyl alcohol (icr) 5% pet. +Cetyl alcohol, stearyl alcohol 20% pet. + + +Cetylpyridinium chloride 0.1% pet. + +Chamomilla recutita (chamomile extract) (icr) 2.5% pet.Chamomilla romana see Anthemis nobilisChlorambucil 2% pet.Chloramine-T (icr) 0.05% aq.Chloramphenicol (icr) 5% pet. + + 10% pet.Chlorhexidine diacetate (ph, icr) 0.5% aq.Chlorhexidine digluconate (ph) (icr) 0.5% aq. + + +Chlormezanone (fde) 10% pet. or alc.Chloroacetamide 0.2% pet. + + +p-Chloro-m-cresol (PCMX) (icr) 1% pet. + + +5-Chloro-2-methyl-4-isothiazolin-3-one 0.01–0.02% aq.5-Chloro-2-methylisothiazol-3-one (MCI), 0.01% aq. + + +

2-methylisothiazol-3-one (MI) 5-Chloro-1-methyl-4-nitroimidazole 0.1% pet.Chlorothalonil (icr) 0.001–0.01% acet.Chloroxylenol 1% pet. 0.5% pet. 1% pet.Chlorphenesin 1% pet.Chlorpheniramine maleate 5% pet. +Chlorpromazine hydrochloride (phde) (icr) 0.1–1% pet. or aq. 0.1% pet. 1% pet.Chlorquinaldol (ph) 5% pet. + + +Chlortetracycline hydrochloride 5% pet. 1% pet.Chromic chloride 1% pet.Chromic potassium sulfate 2% aq.Chromic sulfate 0.5% pet.Chrysanthemum cinerariaefolium 1% pet. +

(pyrethrum) (icr)Chrysanthemum parthenium 1% pet.

(feverfew flower extract)Cimetidine (de) 1% aq.Cinchocaine® See Dibucaine hydrochlorideCinnamal (cinnamic aldehyde) (ph) (icr) 1% pet. + 2% pet. +Cinnamic acid (icr) 5% pet.Cinnamomum cassia (cinnamon oil) (ph)(icr) 0.5% pet.Cinnamyl alcohol 1–5% pet. 1% pet. 2% pet. 1% pet.Cinnoxicam 1% pet.


49

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Table 2. Continued


Trolab Chemo Brial

Ciprofloxacin (fde) 10% pet.Citiolone (fde) 10% DMSOCitronellal 2% pet.Citrus aurantium dulcis (neroli oil) (ph) 2% pet. + +Citrus bergamia (bergamot oil) (ph) 2% pet.Citrus dulcis (orange oil) (ph) 2% pet.Citrus limonum (lemon oil) (ph) 2% pet. + +Clioquinol® (icr) 5% pet. + + +Clarithromycin (fde) 10% aq.Clindamycin phosphate (de) 1–20% aq. or pet.Clobetasol-17-propionate (icr) 1% alc. 0.25% pet. 1% pet. 0.25% pet.Clobetasone butyrate 1% alc.Clomipramine (phde) 0.1% pet.Clonidine 1% pet.Cloprednol 1% alc.Clotrimazole 5% pet./1% alc. + (pet.) + (pet)Clove oil See Eugenia caryophyllusCloxacillin (de) (icr) PureCoal tar See Pix ex carboneCobalt chloride (ph) (icr) 1% pet. + + +Cobaltous sulfate (ph) 2.5% pet.Cocamide DEA 0.5% pet. + + +Cocamidopropyl betaine 1% aq. + + 1%

alc./aq.Codeine phosphate (de) 0.05% aq.Cold cream PureColophonium (rosin) (ph) (icr) 20% pet. + + +Compositae mix (Tanacetum vulgare, 6% pet. 5% pet. 5% pet.

Arnica montana, parthenolide,Chamomilla romana, Achillea millefolium)

Congo red 2% pet.Copper oxide See Cupric oxideCopper 8-quinolinate 1% pet.Copper sulfate See Cupric sulfateCorticosteroid mix (budesonide, tixocortol 2.1% pet.

pivalate, hydrocortisone-17-butyrate)Coumarin (ph) 1% pet.Coumarone indene resin 20% pet.p-Cresol 1% aq.Cresyl glycidyl ether (icr) 0.25% pet. + +Croconazole 1% alc.Cromoglicate sodium See CromolynCromolyn (cromoglicate sodium) (icr) 2% aq. 2% pet.Crotamiton 3% pet.Cupric oxide (copper oxide) 5% pet.Cupric sulfate (copper sulfate) (icr) 1% pet. 2% pet. 1% aq.;

2% pet.Cyclohexanone resin 1% pet.Cycloheximide 1% pet.N-Cyclohexylbenzothiazyl sulfenamide (CBS) 1% pet. + + +N-Cyclohexyl-N-phenyl-p-phenylene-diamine 1% pet.

(CPPD)Cyclohexyl thiophthalimide 1% pet. 0.5% pet. + +Cyclomethycaine hydrochloride 1% pet.Cyclopentolate hydrochloride 0.5% aq.Cymbopogon schoenanthus (lemon grass oil) (ph) 2% pet. + +Dandelion See Taraxacum officinaleDazomet 0.1% pet.D and C red 31 See Brilliant lake red RD and C yellow 11 See Solvent yellow 33


49_907_928 05.11.2005 12:13 Uhr Seite 913

Table 2. Continued


Trolab Chemo Brial

DDT 1% pet. or acet.Desketoprofen 1% pet.Desonide 1% alc.Desoximetasone (ph) 1% alc.Dexamethasone 0.5% pet.Dexamethasone acetate 1% alc.Dexamethasone phosphate 1% alc.Dexamethasone 21-phosphate disodium salt 1% pet.Dexpanthenol See PanthenolDiallyl disulfide 1% -5% pet. 1% pet.4,4´-Diaminodiphenylmethane (ph) 0.5% pet. + + +Diazolidinyl urea 2% pet. + + +Dibenzothiazyl disulfide (MBTS) 1% pet. + + +Dibenzthione (sulbentine) 3% pet.1,2-Dibromo-2,4-dicyanobutane See Methyldibromo glutaronitrileDibromosalicylanilide (ph) 1% pet.Dibucaine hydrochloride (Cinchocaine ®) (ph) 5% pet. + + +Dibutyl phthalate 5% pet. + + +Dibutylthiourea 1% pet. + + +Dibutyl- and diethylthiourea mix 1% pet.Dichlorophene (ph) 0.5% pet. + 1% pet. +Diclofenac sodium 1% pet. 5% pet.Dicyanodiamide 0.1% aq.Dicyclohexylcarbodiimide 0.1% acet. and lowerDiethanolamine 2% pet. + +Diethyleneglycol diacrylate (DEGDA) 0.1% pet. +Diethylenetriamine (DETA) 1% pet. 0.5% pet. +Di-2-ethylhexyl phthalate (DEHP) See Dioctyl phthalateDiethyl phthalate 5% pet.Diethylstilbestrol 1% pet.Diethylthiourea 1% pet. +Diflorasone diacetate 1% alc.Diflucortolone pivalate 1% alc.Difolatan 0.1% pet.Diglycolamine [2-(2-aminoethoxy)ethanol] 1% pet.Dihydroquinidine (de) Pulverized tablet, pureDihydrostreptomycin 0.1% pet.4,4´-Dihydroxydiphenyl 0.1% pet. 0.1% pet.Diisopropyl carbodiimide 0.1% acet. and lowerDiltiazem (de) 1% pet.Dimethylaminoethyl ether 1% pet.N, N-Dimethylaminoethyl methacrylate 0.2% pet.Dimethylaminopropylamine 1% aq.Dimethylaminopropyl ethyl carbodiimide 0.1% acet. and lowerDimethyl dihydroxyethyleneurea 4.5% aq.Dimethylol dihydroxyethyleneurea 5% aq.4,4-Dimethyloxazolidine/3,4,4,trimethyl- See Bioban® CS-1135

oxazolidineN, N´-Dimethyl-p-phenylenediamine 0.25% pet.Dimethyl phthalate 5% pet. + +Dimethylol propylene urea 5% aq.N, N-Dimethyl-p-toluidine 2% pet. 5% pet. 2% pet.N, N-di-β-Naphthyl-p-phenylenediamine 1% pet.

(DBNPD)2,4-Dinitrochlorobenzene (DNCB) (icr) 0.01–0.1% aq. or acet.Dioctyl phthalate (di-2-ethylhexyl phthalate) (icr) 5% pet. + 2% pet. +Dipentamethylenethiuram disulfide 0.25% pet. 1% pet. 0.25% pet.Dipentamethylenethiuram tetrasulfide 0.25% pet.Dipentene (D-limonene) 2% pet. + 1% pet. +Diperocaine 1% pet.


49

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Table 2. Continued


Trolab Chemo Brial

Diphenhydramine hydrochloride (ph) 1% pet. +1,3-Diphenylguanidine (DPG) (icr) 1% pet. + + +Diphenylmethane 4,4-diisocyanate (MDI) (icr) 2% pet. + 1% pet.N, N’-Diphenyl-p-phenylenediamine (DPPD) 1% pet. 0.25% pet. 1% pet. 0.25% pet.Diphenylthiourea (DPTU) 1% pet. + + +Dipivalyl epinephrine hydrochloride 1% aq.Dipyrone (metamizole) (fde) (icr) 10% pet. 1% pet.Direct black 38 (CI 30235) 1% pet.Direct orange 34 (CI 40215) 1% pet. 5% pet.Disodium EDTA (edetic acid disodium salt) 1% pet. + + +Disperse black 1 (CI 11365) 1% pet.Disperse black 2 (CI 11255) 1% pet.Disperse blue 1 (CI 64500) 1% pet. +Disperse blue 3 (CI 61505) 1% pet. + + +Disperse blue 7 (CI 62500) 1% pet.Disperse blue 26 (CI 63305) 1% pet.Disperse blue 35 (ph) 1% pet. +Disperse blue 85 (CI 11370) 1% pet. +Disperse blue 102 1% pet.Disperse blue 106 (CI 111935) 1% pet. +Disperse blue 124 1% pet. +Disperse blue 153 1% pet. +Disperse blue mix (124/106) 1% pet. + +Disperse brown 1 (CI 11153) 1% pet. +Disperse orange 1 (CI 11080) 1% pet. +Disperse orange 3 (CI 11005) 1% pet. + + +Disperse orange 13 (CI 26080) 1% pet.Disperse orange 76 1% pet.Disperse red 1 (CI 11110) 1% pet. + + +Disperse red 11 (CI 62015) 1% pet. + +Disperse red 17 (CI 11210) 1% pet. + + +Disperse red 153 1% pet.Disperse yellow 1 (CI 10345) 1% pet.Disperse yellow 3 (CI 11855) 1% pet. + + +Disperse yellow 9 (CI 10375) 1% pet. + + +Disperse yellow 27 1% pet.Disperse yellow 39 1% pet.Disperse yellow 49 1% pet.Disperse yellow 54 (CI 47020) 1% pet.Disperse yellow 64 (CI 47023) 1% pet.4,4´-Dithiodimorpholine 1% pet.Dithranol 0.02% pet.Di-o-tolyl biguanidine 1% pet.Diurethane dimethacrylate 2% pet. 2% pet.DMDM hydantoin 2% aq. + + +Dodecyldi(aminoethyl)glycine (DDAG) 0.5% aq.Dodecyl dimethyl ammonium chloride 0.01–0.1–1% aq

(quaternium-12).Dodecyl gallate (lauryl gallate) 0.3% pet. 0.25% pet. 0.3% pet.Dodecyl mercaptan 0.1% pet. + +Doxepin 5% pet.Doxycycline (phde) (fde) 10% alc. or pet.Drometrizole [2-(2´-hydroxy-5´-methyl- 1% pet.

phenyl)benzotriazole]Echothiophate iodine 1% aq.Econazole nitrate 1% alc. +Edetic acid disodium salt See Disodium EDTAEnilconazole 1% alc.Eosine (ph) 5% pet. 50% pet.Ephedrine hydrochloride (de) 5% aq. 1% pet.


49_907_928 05.11.2005 12:13 Uhr Seite 915

Table 2. Continued


Trolab Chemo Brial

Epichlorohydrin 0.1% pet.Epinephrine 1% aq.Epoxy acrylate 0.5% pet.Epoxy resin (icr) 1% pet. + + +Epoxy resin, cycloaliphatic 0.5% pet.Erythromycin (base and salts) (de) 1% pet. + +Erythrosine (ph) 0.25% pet.;

alc./glyc.Estradiol 2% alc.Ethacridine lactate monohydrate (Rivanol®) 2% pet.Ethanolamine (monoethanolamine) 2% pet. 2% pet.Ethenzamide (fde) 20% pet.Ethoxyquin (ph) 1% pet. 0.5% pet.Ethyl acrylate (EA) 0.1% pet. +Ethyl alcohol 10% aq.7-Ethylbicyclooxazolidine See Bioban® CS-1246Ethylbutyl thiourea 1% pet.Ethyl cyanoacrylate 5% pet. 10% pet.Ethylenediamine dihydrochloride (ph) (icr) 1% pet. + + +Ethyleneglycol dimethacrylate (EGDMA) 2% pet. + + +Ethylene thiourea See 2-ImidazolidinethioneEthylene urea See 2-ImidazolidinoneEthyleneurea + melamine-formaldehyde 5% pet.2-Ethylhexyl acrylate (EHA) 0.1% pet. + +2-Ethylhexyl-p-dimethylaminobenzoate See Octyl dimethyl PABA2-Ethylhexyl-p-methoxycinnamate see Octyl methoxycinnamate4-(N-Ethyl-N-2-hydroxyethyl)-2-methyl- 1% pet. + +

phenylenediamine sulfate (CD 4)Ethyl methacrylate (EMA) 2% pet. +Ethylparaben (icr) 3% pet. + + +Ethyl sebacate 2% alc.N-Ethyl-4-toluenesulfonamide 0.1% pet.Etofenamate (icr) 2% pet.Eucalyptus globulus (eucalyptus oil) 2% pet. + +Eucerin, anhydrous (lanolin) Pure +Eugenia caryophyllus (clove oil) 2% pet. + +Eugenol (icr) (ph) 2% pet. 1% pet. + 1% pet.Euxyl ® K 400 1% pet. 1% pet. 1% pet.Evernia prunastri (oak moss absolute) (ph) 1% pet. + + +Evernic acid (ph) 0.1% pet.Fagus sylvatica (beech tar) 3% pet.Famciclovir 10% aq.Feneticillin (de) PureFenoprofen 5% pet.Fentichlor (ph) 1% pet.Fenticonazole 1% alc.Feprazone 5% pet.Ferrous chloride 2% alc./

glyc.Ferrous sulfate 5% pet.Feverfew flower extract See Chrysanthemum partheniumFluazinam 0.5% pet.Fludrocortisone acetate 1% alc.Flufenamic acid 1% pet.Flumethasone acetate 1% alc.Fluocinolone acetonide 1% alc.Fluocinonide 1% alc.Fluocortolone 1% alc.Fluorouracil 1% pet.Flurbiprofen 5% pet.


49

49_907_928 05.11.2005 12:13 Uhr Seite 916

Table 2. Continued


Trolab Chemo Brial

Flutamide (phde) 1–20% acet. or pet.Fluticasone propionate 1% alc.Folpet 0.1% pet.Formaldehyde (ph) (icr) 1% aq. + + +Formic acid 1% aq.Fragrance mix (ph) (cinnamic alcohol, 8% pet. + + +

cinnamal, hydroxy citronellal,α-amyl-cinnamal, geraniol, eugenol,iso-eugenol, oakmoss absolute)

Framycetin (neomycin B) 20% pet. 10% pet.Fusidic acid sodium salt 2% pet. + +Gallium oxide 1% pet.Ganciclovir 20% aq.Gentamicin sulfate (icr) 20% pet. + + +Geraniol (icr) 2% pet. 1% pet. 1% pet. 1% pet.Geranium oil, Bourbon 2% pet.Glutaral 0.2–0.3% pet. 0.3% pet. 0.2% pet. 0.3% pet.Glyceryl thioglycolate (icr) 1% pet. + + +Glyoxal 1% pet./aq. + (pet) + (pet)Glyphosate 1–10% aq.Gold sodium thiomalate (de) (icr) 5% pet.Gold sodium thiosulfate (icr) 0.25% pet. 2% pet.Griseofulvin (phde) 1% pet.Grotan® BK See 1,3,5-Tris(2-hydroxyethyl)-

hexahydrotriazineHalcinonide 1% alc.Haloprogin 1% pet.Halomethasone 1% alc.Hexachlorophene (ph) 1% pet. + + +; 0.5%

pet.Hexamethylene diisocyanate (HDI) 0.1% pet. +Hexamethylenetetramine See MethenamineHydroxymethylpentylcyclohexene- 5% pet.

carboxaldehyde (Lyral®)1,6-Hexanediol diacrylate (HDDA) 0.1% pet. +Hexylresorcinol 0.25% pet. + +Homosalate (homomenthyl salicylate) 5% pet.Homatropine 1% aq.Hydrangenol 0.1% pet.Hydrazine sulfate 1% pet. + +Hydroabietyl alcohol 10% pet + +Hydrochlorothiazide (phde) 1–10% pet.Hydrocortisone (ph) 1% alc./pet. + (pet.) + (pet.)Hydrocortisone aceponate 1% alc.Hydrocortisone acetate 1% alc.Hydrocortisone buteprate 1% alc.Hydrocortisone-17-butyrate 1% alc. 0.1% pet. + 0.1% pet.Hydrogen peroxide 3% aq.Hydromorphone (de) 2% aq.Hydroquinone (HQ) 1% pet. + + +Hydroquinone monobenzylether See MonobenzoneHydroxycitronellal (ph) 1–5% pet. 1% pet. 1% pet. 1% pet.2-Hydroxyethyl acrylate (2-HEA) 0.1% pet + +2-Hydroxyethyl methacrylate (HEMA) 2% pet. 1% pet. + 1% pet.Hydroxyisohexyl-3-cyclohexenecarboxaldehyde See Hydroxymethylpentylcyclo-

hexenecarboxaldehydeHydroxylammonium chloride 0.1% aq.Hydroxylammonium sulfate 0.1% aq.2-Hydroxymethyl-2-nitro-1,3-propanediol See Tris(hydroxymethyl)nitro-

methane


49_907_928 05.11.2005 12:13 Uhr Seite 917

Table 2. Continued


Trolab Chemo Brial

2-(2´-Hydroxy-5´-methylphenyl)benzotriazole See DrometrizoleHydroxymethylpentylcyclohexene- 5% pet. 5% pet.

carboxaldehyde (Lyral®)2-Hydroxypropyl acrylate (HPA) 0.1% pet. +2-Hydroxypropyl methacrylate (HPMA) 2% pet. + +2-Hydroxy-4-trifluoromethylbenzoic acid See TriflusalHypericum perforatum (hypericum oil) 0.5% pet.Ibuprofen (fde) 5–10% pet.Ibuproxam (ph) 2.5% pet.Ichthammol (ammonium bituminosulfonate) 10% pet. +Idoxuridine 1% pet. +2-Imidazolidinethione (ethylene thiourea) 1% pet.2-Imidazolidinone (ethylene urea) 1% pet.Imidazolidinyl urea 2% pet. + + +Indium (III) chloride 1% pet.Indometacin 5% pet. 1% pet.Iodoform 5% pet.Iodopropynyl butylcarbamate 0.2% pet. 0.1% pet.Isoamyl-p-methoxycinnamate (ph) 10% pet. + +Isoconazole nitrate 1% alc.Iso-eugenol 2% pet. 1% pet. + 1% pet.Isophoronediamine (IPD) 0.1% pet. 0.5% pet. + 0.5% pet.Isophorone diisocyanate (IPDI) 1% pet. +Isopropyl dibenzoylmethane (ph) 2% pet.4,4´-Isopropylidenediphenol (Bisphenol A) 1% pet. + +Isopropyl myristate 10% pet. 20% pet. 10% pet.N-Isopropyl-N´-phenyl-p-phenylenediamine 0.1% pet. + + +

(IPPD)Jasminum officinale (jasmine absolute, synthetic) 5–10% pet. 2% pet.Juniperus (juniper tar) 3% pet.Kanamycin sulfate 10% pet. + + +Ketoconazole (icr) 1% alc.Ketoprofen (phde) (icr) 1% pet.Ketotifen 2.5% pet./0.7% aq.Lanette E ® 20% pet.Lanette N ® 20% pet.Lanoconazole 1% alc.Lanolin Pure 30% pet.Lanolin alcohol (wool wax alcohols) (icr) 30% pet. + + +Lanolin alcohol and paraffinum liquidum 50% pet. + + +

(Amerchol® L 101)Laurus nobilis (laurel oil) 2% pet. + +Lauryl gallate See Dodecyl gallateLavandula angustifolia (lavender, absolute) (ph) 2% pet.Lemon grass oil See Cymbopogon schoenanthusLemon oil See Citrus limonumLevobunolol hydrochloride 1% aq.Lichen acid mix (atranorin, evernic acid, 0.3% pet.

usnic acid)Lidocaine hydrochloride (icr) 5% pet. 15% pet. + 15% pet.D-Limonene See DipenteneLincomycin hydrochloride 1% aq.Lindane (icr) 1% pet.Lomefloxacin (phde) 1–10% pet.Lyral® See Hydroxymethylpentylcyclo-

hexenecarboxaldehydeMafenide 10% pet. +Malathion 0.5% pet.Maneb (ph) 0.5–1% pet.Mechlorethamine hydrochloride (icr) 0.02% aq.


49

49_907_928 05.11.2005 12:13 Uhr Seite 918

Table 2. Continued


Trolab Chemo Brial

Medroxyprogesterone acetate 1% pet.Mefenamic acid (fde) 1–10% pet.Melaleuca alternifolia (tea tree oil) 5% pet.Melamine formaldehyde 7% pet.Mentha piperita (peppermint oil) (icr) 2% pet. + +Menthol (icr) 1% pet. 2% pet. 1% pet.Mepivacaine 1% pet. +Merbromin (mercurochrome) 2% aq. or pet.2-Mercaptobenzimidazole See 2-BenzimidazolethiolMercaptobenzothiazole (MBT) (icr) 2% pet. + + +Mercapto mix (mercaptobenzothiazole 1% pet. + + +

dibenzothiazyl disulfide, morpholinyl mercaptobenzothiazole, N-cyclohexyl-benzo-thiazyl sulfenamide)

Mercuric chloride 0.1% pet. +Mercurochrome See MerbrominMercury (icr) 0.5% pet. + +Mesulfen 5% pet.Metamizol See DipyroneMetanil yellow See Acid yellow 36Methenamine (hexamethylenetetramine) 2% pet 1% pet. + 1% pet.Methyl-3-amino-4-N, N-diethyl-aniline (CD 2) 1% pet. 1% pet.p-Methylaminophenol sulfate (Metol®)(icr) 1% pet. 1% pet.Methyl anthranilate 5% pet.4-Methylbenzylidene camphor (ph) 10% pet. + + +Methylcoumarin (6-MC) (ph) 1% pet.Methyldibromo glutaronitrile (1,2-dibromo-2,4- 0.3% pet. + + 0.1% pet.

dicyanobutane)Methyldichlorobenzene sulfonate 0.1% pet.N, N-Methylenebisacrylamide (MBAA) 1% pet. +Methylene-bis(methyloxazolidine) 1% pet.α-Methylene-γ-butyrolactone (tulipalin) 0.001% alc. 0.01% pet.Methylhydroquinone (MHQ) 1% pet.2-Methyl-4-isothiazolin-3-one 0.01–0.02% aq.Methyl methacrylate (MMA) 2% pet. + + +N-Methylolchloroacetamide 0.1% pet.Methyl orange 2% pet.Methylparaben (icr) 3% pet. + + +Methylprednisolone aceponate 1% alc.Methylprednisolone acetate 1% alc.Methyl salicylate (icr) 2% pet. +3-Methyl thiazolidone 2-thion 1% pet.Methyl-p-toluene sulfonate 0.1% pet.Methyl violet 0.5% pet.Metipranolol 2% aq.Metol ® See p-Methylaminophenol sulfateMetoprolol (de) 3% aq. / 10% pet.Metronidazole (fde) 1% pet., 50% pet. 1% pet.Mexenone See Benzophenone-10Miconazole nitrate 1% alc. +Minoxidil 5% in aq. + 20% prop. glyc.Mitomycin C 0.1% pet.Mofebutazone 1% pet.Mometasone furoate 1% alc.Monobenzone (monobenzylether of 1% pet. + + +

hydroquinone)Monobenzylether of hydroquinone See MonobenzoneMonoethanolamine See Ethanolamine


49_907_928 05.11.2005 12:13 Uhr Seite 919

Table 2. Continued


Trolab Chemo Brial

2-Monomethylol phenol 1% pet.Morpholinyl mercaptobenzothiazole (MOR) (icr) 0.5% pet. + 1% pet. 1% pet.Mupirocin 10% pet.Musk ambrette (ph) 5% pet. +Musk ketone (ph) 1% pet.Musk mix (xylene, tibetene, moskene, ketone) 3% pet.Musk moskene (ph) 1% pet.Musk xylene (ph) 1% pet.Myristyl alcohol 5% pet.Myroxylon pereirae (balsam of Peru) (ph) (icr) 25% pet. + + +Myroxylon toluiferum (balsam of Tolu) 20% pet. 10% alc. 20% pet.Naftifine hydrochloride 5% alc.1-Naphthalenethiourea (ANTU) 1% pet.Naphthol AS (CI 37505) 1% pet. + +Naphthyl mix (N, N-di-β-naphthyl-p-phenylene- 1% pet.

diamine, N-phenyl-2-naphthy-lamine)Naproxen 5% pet.Narcissus absolute 2% pet.Neomycin sulfate (icr) 20% pet. + + +Neroli oil See Citrus aurantium dulcisNeticonazole 1% alc.Nickel sulfate (icr) 5% pet. + + +Nicotine (icr) 10% pet.Nifuroxazide (de) 0.001–1% aq./10% pet.Nigrosine 1% pet. +Nimesulide (fde) 1–10% pet.(Nitrobutyl)morpholine/(ethylnitrotrimethylen) see Bioban®

dimorpholineNitrofurazone 1% pet. + +Nitroglycerin (icr) 1% pet.2-Nitro-p-phenylenediamine (ONPPD) 1% pet. + +Nonoxynol 5% aq.Nordihydroguaiaretic acid 2% pet.Norethisterone acetate 1% alc.Nystatin (de) 2% pet. + +Oak moss absolute See Evernia prunastriOctyl dimethyl PABA (2-ethylhexyl-p-dimethyl- 10% pet. + + +

aminobenzoate) (ph)Octyl gallate 0.3% pet. 0.25% pet. 0.3% pet.Octylisothiazolinone 0.1% pet. 0.025% pet. +Octyl methoxycinnamate (2-ethylhexyl-p- 10% pet. + + +

methoxycinnamate) (ph)Octyl phthalate 5% pet.Octyl triazone (ph) 10% pet.Ofloxacin (fde) 20% pet.Olaquindox (ph) 1% pet.Olea europaea (olive oil) PureOleamidopropyl dimethylamine 0.1% aq.Oleyl alcohol 30% pet.Oligotriacrylate 480 0.1% pet. +Olive oil See Olea europaeaOrange oil See Citrus dulcisOrthocaine 1% pet.Oxiconazole 1% alc.Oxprenolol (de) 10% pet.Oxybenzone See Benzophenone-3Oxybuprocaine (benoxinate) 1% pet.Oxyphenbutazone (de) (icr) 1–5% pet. 10% pet.Oxytetracycline 3% pet. + +PABA (ph) 10% pet. + + +


49

49_907_928 05.11.2005 12:13 Uhr Seite 920

Table 2. Continued


Trolab Chemo Brial

Palladium chloride (icr) 1% pet. + 2% pet. +Panthenol (dexpanthenol) (icr) 50% aq. 5% pet. 5% pet.Papain 1% pet. 1% pet.Paraben mix (butyl, ethyl, methyl, propyl- 16% pet. 16% pet. 16% pet

paraben) (icr).Paracetamol 10% pet.Paraquat 0.1% pet.Paromomycin 10% pet.Parthenolide 0.1% pet.Pecilocin 1% pet.PEG 6 (and) PEG 32 (polyethylene glycol Pure + +

ointment)PEG 400 (icr) PurePenbutolol sulfate 2% aq.Penethamate 1% pet.D-Penicillamine 1% aq.Penicillin G (de) (icr) 100,000 U/g aq. or pet.Pentachloronitrobenzene 1% pet.Pentaerythritol triacrylate (PETA) 0.1% pet. +Peppermint oil See Mentha piperitaPerfume mix (cinnamic alcohol, cinnamal, 6% pet.

hydroxycitronellal, eugenol, iso-eugenol,geraniol)

Petrolatum, white (icr) Pure + + +Phenacetin 10% pet.Phenazone See AntipyrinePhenidone ® See 1-Phenyl-3-pyrazolidinonePhenobarbital (de) 1–20% pet.Phenol-formaldehyde resin (P-F-R-2) 5% pet. 1% pet. 5% pet.Phenolphthalein 0.5% pet.Phenoxyethanol (icr) 1% pet. + + +Phenyl-azo-2-naphthol (PAN) 0.1% pet.Phenylbenzimidazole sulfonic acid (ph) 10% pet. + + +Phenylbutazone (de) (icr) 1–5% pet. 10% pet.p-Phenylenediamine dihydrochloride 0.5% pet.p-Phenylenediamine free base (ph) (icr) 1% pet. + + +Phenylephrine hydrochloride 10% aq. + 10% cocaPhenyl glycidyl ether (icr) 0.25% pet. 0.25% petPhenylhydrazine 1% pet.α-Phenylindole 2% pet.Phenyl isocyanate 0.1% pet.Phenylmercuric acetate (icr) 0.01% aq. 0.05% pet. + 0.05% pet.Phenylmercuric borate 0.05% pet.Phenylmercuric nitrate (icr) 0.05% pet. 0.01% pet.Phenyl-β-naphthylamine (PBN) 1% pet. + +o-Phenylphenol (ph) (icr) 1% pet.Phenyl-p-phenylenediamine 0.25% pet.1-Phenyl-3-pyrazolidinone (Phenidone®) 1% pet. + +Phenyl salicylate 1% pet. + + +Phosphorus sesquisulfide (icr) 0.5% pet.Picric acid 1–2% pet.Piketoprofen 2.5% pet.Pilocarpine hydrochloride (icr) 1% pet. 1% aq. 1% alc./

glyc.Pindolol 2% pet.Pinus (pine tar) 3% pet. + +Piperazine (de) 1% pet. or aq.Piroxicam (phde) (de) 1–10% pet.Pix ex carbone (coal tar) (ph) (icr) 5% pet. + +Polidocanol 3% pet. + +


49_907_928 05.11.2005 12:13 Uhr Seite 921

Table 2. Continued


Trolab Chemo Brial

Polyethylene glycol-400 See PEG 400Polyethylene glycol ointment See PEG 6 (and) PEG 32Polymyxin B sulfate 3% pet. + 5% pet. +Polyoxyethylene sorbitan monolaurate See Polysorbate 20Polyoxyethylene sorbitan monooleate See Polysorbate 80Polyoxyethylene sorbitan monopalmitate See Polysorbate 40Polysorbate 20 (polyoxyethylene sorbitan 5% pet.

monolaurate) (icr)Polysorbate 40 (polyoxyethylene sorbitan 5% pet. 10% pet.

monopalmitate) (icr)Polysorbate 80 (polyoxyethylene sorbitan 5% pet. + 10% pet.

monooleate) (icr)Potassium dichromate (ph) 0.5% pet. + & 0.25% + +

pet.Potassium dicyanoaurate 0.002% aq. 0.1% aq. 0.002%

pet.Povidone-iodine (icr) 10% aq. or pet. 10% aq.PPP-HB 5% alc.Pramocaine hydrochloride 1% pet.Pravastatin (de) Pulverized tablet purePrednicarbate 1% alc.Prednisolone 1% alc. 1% pet. 0.5% pet.Prilocaine hydrochloride 5% pet. +Primin 0.01% pet. + + +Pristinamycin (icr) (de) 1–10% pet. or aq.Procaine hydrochloride (ph) (icr) 1–2% pet. 2% pet. 1% pet. 2% pet.Proflavine hydrochloride 1% pet.Promethazine hydrochloride (phde) (icr) (fde) 1–10% pet. 0.1% pet. 1% pet. 2% pet.Propanidid 5% pet.Propantheline bromide 5% pet.Proparacaine (proxymetacaine) 2% pet.Propicillin (de) 20% pet.Propionic acid 3% pet.Propipocaine 1% pet.Propolis 10% pet. + + +Propranolol hydrochloride (de) 10–20% pet. 2% pet.Propylene glycol (icr) 5% pet. or aq. 5% pet./ 5% pet. 20% aq.

20% aq.Propylene oxide 0.1–1% alc.Propyl gallate 1% pet. 0.5% pet. 1% pet. 0.5% pet.Propylparaben (icr) 3% pet. + + +Propyphenazone (icr) 1% pet.Proxymetacaine See ProparacainePyrazinamide (de) 1–10% alc.Pyrethrum See Chrysanthemum

cinerariaefoliumPyridoxine hydrochloride (ph) (de) 10% pet.Pyrilamine maleate 2% pet.Pyritinol (phde) 20% pet.Pyrogallol 1% pet. + +Pyrrolnitrin 1% pet.Quaternium-12 See Dodecyl dimethyl ammonium

chlorideQuaternium-15 1% pet. + + +Quindoxin (ph) 0.1% pet.Quinidine sulfate (phde) 1% pet. + +Quinine sulfate (phde) 1% pet. + 25% pet.Quinoline mix (clioquinol, chlorquinaldol) 6% pet.4-Quinolines (phde) 10% pet.Quinoline yellow 0.1% coca


49

49_907_928 05.11.2005 12:13 Uhr Seite 922

Table 2. Continued


Trolab Chemo Brial

Ranitidine (de) 1% pet.Reactive black 5 (CI 20505) 1% pet.Reactive blue 21 (CI 18097) 1% pet.Reactive blue 238 1% pet.Reactive orange 107 1% pet.Reactive red 123 1% pet.Reactive red 228 1% pet.Reactive red 238 1% pet.Reactive violet 5 (CI 18097) 1% pet.Resorcinol (icr) 1% pet. + +Resorcinol monobenzoate 1% pet.Resorcinol/formaldehyde resin 5% pet.Retinoic acid 0.005% alc.Rhodium sulfate (icr) 0.05% aq.Ribostamycin 20% pet.Rifamycin (icr) 2.5% pet.Rivanol® See Ethacridine lactate

monohydrateRosa (rose oil) 0.5% pet.Rosa centifolia (rose oil, Bulgarian) 2% pet.Rosemary (rosemary oil) 0.5% pet.Rosin See ColophoniumRubidium iodide 1% pet.Ruthenium (icr) 0.1% pet.Salicylaldehyde 2% pet. + +Salicylic acid (icr) 1% pet. 5% pet.Sandalwood oil See Santalum albumSantalum album (sandalwood oil) (ph) 10% pet. 2% pet.Scopolamine hydrobromide 0.25% aq.Sertaconazole 1% alc.Sertraline (de) 5–10% alc. or pet.Sesamum indicum (sesame oil) PureSesquiterpene lactone mix (alantolactone, 0.1% pet. + +

costunolide, dehydrocostus lactone)Silicon tetrachloride 2% pet.Silver colloidal 0.1% pet.Silver nitrate (ph) 1% aq.Silver protein 3% pet.Simvastatin (phde) 10% pet.Sisomicin 20% pet.Sodium benzoate (icr) 5% pet. + + +Sodium disulfite 1% pet.Sodium fusidate See Fusidic acid sodium saltSodium hypochlorite (icr) 0.5% aq.Sodium hyposulfite 1% aq.Sodium lauryl sulfate 0.1% aq.Sodium metabisulfite 1% pet.Sodium nitrite 2% aq./

glyc.Sodium omadine See Sodium pyrithioneSodium pyrithione (sodium omadine) 0.1% aq.Sodium thiosulfoaurate 0.25% pet. 0.25% pet.Sodium valproate (de) 1–5% pet.Solvent red 23 (Sudan III) 2% pet. 1% pet.Solvent red 24 (Sudan IV) 2% pet.Solvent yellow 1 See p-AminoazobenzeneSolvent yellow 33 (D and C yellow 11, CI 47000) 0.1% pet.Sorbic acid (icr) 2% pet. + + +; 2%

alc./glyc.Sorbitan laurate (Span® 20) (icr) 5% aq.


49_907_928 05.11.2005 12:13 Uhr Seite 923

Table 2. Continued


Trolab Chemo Brial

Sorbitan oleate (Span® 80) 5% aq. 5% pet.Sorbitan palmitate (Span® 40) 5% aq.Sorbitan sesquioleate (icr) 20% pet. + 2% pet. +Spiramycin sulfate (de) 5–10% pet.Stannous chloride 1% pet. 0.5% pet. 0.5% pet.Stearyl alcohol (icr) 30% pet. +Stepronin (de) 18% sol.Streptomycin (sulfate) (icr) 1–2.5% pet. 5% pet.Styrax benzoin (benzoin resin) (icr) 2% pet. 10% alc./

glyc./aq.Styrenated phenol 1% pet.Sudan III See Solvent red 23Sudan IV See Solvent red 24Sulbentine See DibenzthioneSulconazole nitrate 1% alc.Sulfacetamide 5% pet.Sulfamethoxazole (de) PureSulfanilamide (ph) 5% pet. + + +Sulfasalazine (fde) 10% pet.Sulfur dioxide (icr) 2% aq.Sulfur, pharmaceutical (precipitated) 10% pet.Sulindac 1% pet.Sulisobenzone See Benzophenone-4Suprofen 0.1% pet.Tacalcitol 2 µg/ml alc.Tacrolimus 2.5% pet.Tanacetum vulgare (tansy extract) 1% pet. + +Tansy extract See Tanacetum vulgareTantalum 1% pet.Taraxacum officinale (dandelion) 2.5% pet.Tea tree oil See Melaleuca alternifoliaTego® 103 G 0.1% aq.Tenoxicam (fde) 1–10% pet.Terpene phenolic resin 20% pet.Testosterone propionate 1% alc.Tetracaine hydrochloride (amethocaine) 1% pet. + 5% pet. +Tetrachlorosalicylanilide (TSCA) (ph) 0.1% pet.Tetracycline hydrochloride 2% pet. 2% pet.Tetraethylene glycol dimethacrylate 2% pet.Tetraethylthiuram disulfide (TETD) 0.25% pet. 1% pet. 0.25% pet.Tetrahydrofurfuryl methacrylate (THFMA) 2% pet. +Tetramethylbenzidine 0.1% pet.Tetramethyl butanediamine 1% pet.Tetramethylol acetylenediurea 5% aq.Tetramethylthiuram disulfide (TMTD) 0.25% pet. 1% pet. 0.25% pet.Tetramethylthiuram monosulfide (TMTM) 0.25% pet. 1% pet. 0.25% pet.Tetrazepam (phde) 10% pet.Thiabendazole 1% pet.Thiamphenicol 5% pet.Thimerosal (icr) 0.1% pet. + +Thioridazine (phde) 1% pet.Thiourea (ph) 0.1% pet. + + +Thioxolone 0.5% alc.Thiram 1% pet.Thiuram mix (tetramethylthiuram monosulfide, 1% pet. + + +

tetramethylthiuram disulfide, tetraethyl-thiuram disulfide, dipentamethylenethiuram disulfide)

Tiaprofenic acid (phde) 1% pet.Timolol 0.5% aq.


49

49_907_928 05.11.2005 12:13 Uhr Seite 924

Table 2. Continued


Trolab Chemo Brial

Tin (icr) 50% pet.Tinopal CH 3566 1% pet.Tiocolchicoside 1% pet.Tioconazole 1% alc.Tiopronin (de) 0.3–5% pet.Titanium-(IV)-oxide 0.1% pet.Tixocortol pivalate 0.1–1% pet. 0.1% pet.Tobramycin (de) 5% aq. or 20% pet.α-Tocopherol (vitamin E) (icr) 10% pet.Tolazoline 10% aq.Tolnaftate 1% pet.Toluene-2,5-diamine (p-toluenediamine) (PTD) 1% pet. + + +Toluene diisocyanate (TDI) 2% pet. + 1% pet.Toluenesulfonamide/formaldehyde resin See Tosylamide/formaldehyde resinToluenesulfonhydrazide 0.5% alc.4-Tolyldiethanolamine 2% pet.Tosylamide/formaldehyde resin (toluene- 10% pet. + + +

sulfonamide/formaldehyde resin)Triamcinolone acetonide 1% alc. 0.1% pet. 1% pet. 0.1% pet.Tribromsalan (TBS) (ph) 1% pet. +Trichloroethylene 5% o.o.(TCC) (ph) 1% pet. + +Triclosan (ph) 2% pet. + + +Tricresyl phosphate 5% pet. + + +Triethanolamine 2.5% pet. + 2% pet. +Triethanolamine polypeptide oleate condensate 25% o.o

(Xerumenex®)Triethyleneglycol diacrylate (TREGDA) 0.1% pet. +Triethyleneglycol dimethacrylate (TREGDMA) 2% pet. + + +Triethylenetetramine (TETA) 0.5% pet. + + +Trifluridine 5% pet.Triflusal (2-hydroxy-4-trifluoro-methylbenzoic 1% pet.

acid) (phde)Triglycidyl isocyanurate 0.5% pet. +Trimeprazine tartrate (alimemazine tartrate) 1% pet.Trimethoprim (de) (fde) 10% alc. or pet.2,2,4-Trimethyl-1,2-dihydroquinoline 1% pet. +Trimethylolpropane triacrylate (TMPTA) 0.1% pet. +Tripelennamine 1% pet.Triphenyl phosphate 5% pet. + + +Tripropyleneglycol diacrylate (TPGDA) 0.1% pet. +1,3,5-Tris(2-hydroxyethyl)-hexahydrotriazine 1% pet. 1% aq.

(Grotan® BK)Tris(hydroxymethyl)nitromethane (tris nitro) 1% pet. + + +Tris nitro See Tris(hydroxymethyl)nitro-

methaneTrolamine See TriethanolamineTromantadine hydrochloride 1% pet.Tropicamide (icr) 1% pet.TSS Agfa® See Amino-4-N, N-diethylaniline

sulfateTuberculin (bovine) 10% aq.Tulipalin See α-Methylene-γ-butyrolactoneTurpentine oil (icr) 10% pet. + +; 20%

pet.Turpentine peroxides (icr) 0.3% o.o. 0.3% pet.Tylosin tartrate 5% pet.Undecylenic acid 2% pet.Urea formaldehyde resin 10% pet. +Urethane diacrylate (aliphatic) 0.1% pet. +


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Table 2. Continued


Trolab Chemo Brial

Urethane diacrylate (aromatic) 0.05% pet. +Urethane dimethacrylate (UEDMA) 2% pet. + +Usnic acid (ph) 0.1% pet. + + +Valaciclovir 10% aq.Vanillin (icr) 10% pet. + + +Vat green 1 (CI 59825) 1% pet.Vesuvine brown See Bismarck BrownVirginiamycin (de) (icr) 5% pet.Vitamin A acetate 1% pet.Vitamin E See α-TocopherolVitamin K (K1, K3, K4) (de) 0.1% pet.Warfarin 0.5% pet.Wood mix (pine, spruce, birch, teak) 20% pet.Wood tar mix (pine, beech, juniper, birch) (ph) 12% pet. 12% pet.Wool wax alcohols See Lanolin alcoholXerumenex® See Triethanolamine polypeptide

oleate condensateYarrow See Achillea millefoliumYlang-ylang oil See Cananga odorataZinc acexamate (de) 5% aq.Zinc chloride (icr) 1% pet. 1% pet.Zinc dibutyldithiocarbamate (ZBC) (icr) 1% pet + + +Zinc diethyldithiocarbamate (ZDC) (icr) 1% pet. + + +Zinc dimethyldithiocarbamate (Ziram) (icr) 1% pet. +Zinc ethylenebis(dithiocarbamate) See ZinebZinc (powder) 2.5% pet. 1% pet.Zinc pyrithione (ph) 1% pet. 1% pet. 0.1% pet.Zineb [zinc ethylenebis(dithiocarbamate)] (ph) 1% pet. + +Ziram See Zinc dimethyldithiocarbamateZirconium oxide 0.1% pet.


49

49_907_928 05.11.2005 12:13 Uhr Seite 926

Table 3. Recommended test concentrations for groups ofchemicals. (acet. Acetone, alc. alcohol, aq. water, pet. petrola-tum.) [icr Immediate contact reactions reported (Chaps. 5 and26), de drug eruption with positive patch test reported(Chap. 24), fde fixed drug eruption with positive patch testreported (Chap. 24), ph photosensitivity reported (Chaps. 6, 17and 27), phde photosensitive drug eruption with positive pho-topatch test reported (Chaps. 6, 17, 24 and 27)]

Product Test concentrationand vehicle

Acrylates, monoacrylates (icr) 0.1% pet.Aminoglycosides (de) 20% pet.Anesthetics, local 0.5–2% aq.Barbiturates (fde) 10% alc. or pet.Benzodiazepines (de) 1% aqua; 5–10%

pet; 5–20% pet oraq.

Beta-lactam antibiotics (de) 1–20% pet.Carbowaxes PureCephalosporins (de) (icr) 10%–20% pet.

or 1%–10% aq.Epoxy resins (DGEBA based) 1% pet.Epoxy resins (not DGEBA based) 0.25–1% pet.Epoxy resin hardeners 0.1–1% in pet.,

acet. or alc.Epoxy resin reactive diluents 0.1–1% in pet.,

acet. or alc.Heparins (de) PureImidazole antimycotics 1% alc.Methacrylates, monomers 2% pet.Penicillins (de) 1–20% pet.Phenothiazine derivatives (fde) 1–10% pet.

or 10% alc.Phytotherapeutics (de) Pure and 10%Polyethylene glycols (icr) PureQuaternary ammonium compounds 0.1% aq.4-Quinolines (phde) 10% pet.Sulfonamides (de) (fde) 10% alc. or pet.Tetracyclines 3% pet.Triphenylmethane dyes 2% aq.


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Table 4. List of abbreviations

HPMA 2-Hydroxypropyl methacrylateHQ HydroquinoneIBA Isobornyl acrylateIPD Isophorone diamineIPDI Isophorone diisocyanateIPPD N-Isopropyl-N´-phenyl-p-phenylenedia-

mineMBAA N, N-MethylenebisacrylamidMBT MercaptobenzothiazoleMBTS Dibenzothiazyl disulfide6-MC MethylcoumarinMCPA Chloromethylphenoxyacetic acidMDI Diphenylmethane-4, 4-diisocyanateMHQ MethylhydroquinoneMMA Methyl methacrylateMOR Morpholinyl mercaptobenzothiazoleONPPD 2-Nitro-p-phenylenediamineOTA OligotriacrylatePAN Phenyl-azo-2-naphtholPBN Phenyl-β-naphthylaminePCMC p-Chloro-m-cresolPCMX ChloroxylenolPCP PentachlorophenolPEA 2-Phenoxyethyl acrylatePETA Pentaerythritol triacrylateP-F-R-2 Phenol-formaldehyde resinPPP PhenylpropylpyridinePTBC p-tert-ButylcatecholPTBT p-tert-Butylphenol-formaldehyde resinPTD Toluene-2,5-diamine2,4,5-T 2,4,5-Trichlorophenoxyacetic acidTBS TribromsalanTCA Sodium thichloroacetateTCC TriclocarbanTCSA TetrachlorosalicylanilideTDI Toluene diisocyanateTETA TriethylenetetramineTETD Tetraethylthiuram disulfideTGIC Tetraglycidyl isocyanaurateTHFMA Tetrahydrofurfuryl methacrylateTMPTA Trimethylolpropane triacrylateTMTD Tetramethylthiuram disulfideTMTM Tetramethylthiuram monosulfideTPGDA Tripropyleneglycol diacrylateTREGDA Triethyleneglycol diacrylateTREGDMA Triethyleneglycol dimethacrylateTSS 4-Amino-N, N-dietyhylaniline sulfateUDA Urethane diacrylateUDMA Urethane dimethacrylateZBC Zinc dibutyldithiocarbamateZDC Zinc diethyldithiocarbamate


49

ANTU 1-NaphthalenylthioureaBA Butyl acrylateBAK Benzalkonium chlorideBIS-EMA 2,2-bis[4-(2-Methacryloxyethoxy)phe-

nyl]propaneBIS-GA 2,2-bis[4-(2-hydroxy-3-acryloxyprop-

oxy)phenyl]propane (epoxy diacrylate)BIS-GMA 2,2-bis[4-(2-Hydroxy-3-methacryloxyprop-

oxy)phenylpropane]BIS-MA 2,2-bis[4-(Methacryloxy)phenyl]propaneBIT BenzisothiazolinoneBMA n-Butyl methacrylateBUDA 1,4-Butanediol diacrylateBUDMA 1,4-Butanediol dimethacrylateCBS N-Cyclohexylbenzothiazyl sulfenamideCDAA N, N-Diallyl-2-chloroacetamideCPPD N-Cyclohexyl-N-phenyl-p-phenylenedia-

mine2,4-D 2,4-Dichlorophenoxyacetic acid2,4-DB 2,4-Dichlorophenoxybutyric acidDBNPD N, N-Di-β-naphthyl-p-phenylenediamineDDAG Dodecyl di(aminoethyl)glycineDDT DichlorodiphenyltrichloroethaneDDVP DichlorvosDEGDA Diethyleneglycol diacrylateDEHP Di-2-ethylhexyl phthalate (=dioctyl phtha-

late)DETA DiethylenetriamineDMAEMA N, N-Dimethylaminoethyl methacrylateDNCB 2,4-DinitrochlorobenzeneDNOC 4,6-DinitrocresolDOP Dioctyl phthalateDPG 1,3-DiphenylguanidineDPGDA Dipropyleneglycol diacrylateDPPD N, N´-Diphenyl-p-phenylenediamineDPTU DiphenylthioureaEA Ethyl acrylateEBADMA Ethoxylated bisphenol-A dimethacrylateECA Ethyl cyanoacrylateEDTA Ethylenediaminetetraacetic acid disodium

salt (see disodium EDTA)EEA Ethoxyethyl acrylateEGDMA Ethyleneglycol dimethacrylateEHA 2-Ethylhexyl acrylateEMA Ethyl methacrylateGMA Glycidyl methacrylateHCH HexachlorocyclohexaneHDDA 1,6-Hexanediol diacrylateHDI Hexamethylenediisocyanate2-HEA 2-Hydroxyethyl acrylateHEMA 2-Hydroxyethyl methacrylateHPA 2-Hydroxypropyl acrylate

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