http://en.wikipedia.org/wiki/Organ_transplantation

Organ transplantationOrgan transplantation is the moving of an organ from one body to another or from a donor site to another location on the patient's own body, for the purpose of replacing the recipient's damaged or absent organ. The emerging field of regenerative medicine is allowing scientists and engineers to create organs to be re-grown from the patient's own cells (stem cells, or cells extracted from the failing organs). Organs and/or tissues that are transplanted within the same person's body are called autografts. Transplants that are recently performed between two subjects of the same species are called allografts. Allografts can either be from a living or cadaveric source.

Organs that can be transplanted are the heart, kidneys, liver, lungs, pancreas, intestine, and thymus. Tissues includebones, tendons (both referred to as musculoskeletal grafts), cornea, skin, heart valves, nerves and veins. Worldwide, the kidneys are the most commonly transplanted organs, followed by the liver and then the heart. The cornea and musculoskeletal grafts are the most commonly transplanted tissues; these outnumberorgan transplants by more than tenfold.

Organ donors may be living, brain dead, or dead via circulatory death.[1] Tissue may be recovered from donors who die of circulatory death, as well as of brain death – up to 24 hours past the cessation of heartbeat. Unlike organs, most tissues (with the exception of corneas) can be preserved and stored for up to fiveyears, meaning they can be "banked". Transplantation raises a number of bioethical issues, including the definition of death, when and how consent should be given for an organ to be transplanted and payment for organs for transplantation.[2][3] Other ethical issues include transplantation tourism and morebroadly the socio-economic context in which organ procurement or transplantation may occur. A particular problem is organ trafficking.[4] Some organs, such as the brain, cannot be transplanted.

Transplantation medicine is one of the most challenging and complex areas of modern medicine. Some of the key areas for medical management are the problems of transplant rejection, during which the body has an immune response to the transplanted organ, possibly leading to transplant failure and the need to

immediately remove the organ from the recipient. When possible, transplant rejection can be reduced through serotyping to determine the most appropriate donor-recipient match and through the use of immunosuppressant drugs.[5]

Contents

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1 History

o 1.1 Timeline of successful transplants

2 Types of transplant

o 2.1 Autograft

o 2.2 Allograft and allotransplantation

2.2.1 Isograft

o 2.3 Xenograft and xenotransplantation

o 2.4 Split transplants

o 2.5 Domino transplants

o 2.6 ABO-incompatible transplants

3 Major organs and tissues transplanted

o 3.1 Thoracic organs

o 3.2 Abdominal organs

o 3.3 Tissues, cells, fluids

4 Types of donor

o 4.1 Living donor

o 4.2 Deceased donor

5 Allocation of donated organs

6 Reasons for donation and ethical issues

o 6.1 Living related donors

6.1.1 Paired exchange

o 6.2 Good Samaritan

o 6.3 Compensated donation

o 6.4 Forced donation

7 Organ transplantation in different countries

o 7.1 Demographics

o 7.2 Comparative costs

o 7.3 Safety

o 7.4 Organ transplant laws

o 7.5 Ethical concerns

o 7.6 Artificial organ transplantation

8 References

9 Sources and bibliography

10 Further reading

11 External links

History[edit]

Successful human allotransplants have a relatively long history of operative skills that were present long before the necessities for post-operative survival were discovered. Rejection and the side effects of preventing rejection (especially infection and nephropathy) were, are, and may always be the key problem.

Several apocryphal accounts of transplants exist well prior to the scientific understanding and advancements that would be necessary for them to have actually occurred. The Chinese physicianPien Chi'ao reportedly exchanged hearts between a man of strong spirit but weak will with one of a man of weak spirit but strong will in an attempt to achieve balance in each man. Roman Catholic accounts report the 3rd-century saints Damian and Cosmas as replacing the gangrenous or cancerous leg of the Roman deacon Justinian with the leg of a recently deceasedEthiopian.[6][7] Most accounts have the saints performing the transplant in the 4th century, many decades after their deaths; some accounts havethem only instructing living surgeons who performed the procedure.

The more likely accounts of early transplants deal with skin transplantation. The first reasonable account is of the Indian surgeon Sushruta in the 2nd century BC, who used autografted skin transplantation in nose reconstruction, a rhinoplasty. Success or failure of these procedures is not well documented. Centuries later, the Italian surgeon Gasparo Tagliacozzi performed successful skin autografts; he also failed consistently with allografts, offering the first suggestion of rejection centuries before that mechanism could possibly be understood. He attributed it to the "force and power of individuality" in his 1596 work De

Curtorum Chirurgia per Insitionem.

Alexis Carrel: 1912's Nobel Prize for his work on organ transplantation.

The first successful corneal allograft transplant was performed in 1837 in a gazelle model; the first successful human corneal transplant, a keratoplastic operation, was performed by Eduard Zirm at Olomouc Eye Clinic, now Czech Republic, in 1905. The first transplant in the modern sense – the implantation of organ tissue in order to replace an organ function – was a thyroidtransplant in 1883. It was performed by the Swiss surgeon and later Nobel laureate Theodor Kocher. In the preceding decades Kocher had perfected the removalof excess thyroid tissue in cases of goiter to an extent that he was able to remove the whole organ without the patient dying from the operation. Kocher carried out the total removal of the organ in some cases as a measure to prevent recurrent goiter. By 1883 the surgeon noticed that the complete removal of the organ leads to a complex of particular symptoms that we today have learned to associate with a lack of thyroid hormone. Kocher reversed these symptoms by implanting thyroid tissue to these patients and thus performed the first organ transplant. In the following years Kocher and other surgeons used thyroid transplantation also to treat thyroid deficiency that had appeared spontaneously, without a preceding organ removal. Thyroid transplantation became the model for a whole new therapeutic strategy, organ transplantation. After the example of the thyroid, other organs were transplanted in the decades around 1900. Some of these transplants were done in animals for purposes of research, where organ removal andtransplantation became a successful strategy of investigating the function of organs. Kocher was awarded his Nobel Prize in 1909 for the discovery of the function of the thyroid gland. At the same time, organs were also transplanted fortreating diseases in humans. The thyroid gland became the model for transplants of

adrenal and para-thyroid glands, pancreas, ovary, testicles and kidney. By 1900 the idea that one can successfully treat internal diseases by replacing a failed organ through transplantation had been generally accepted.[8] Pioneering work in the surgical technique of transplantation was made in the early 1900s by the French surgeon Alexis Carrel, with Charles Guthrie, with the transplantation of arteries or veins. Their skilful anastomosis operations, the new suturing techniques, laid the groundwork for later transplant surgery and won Carrel the 1912 Nobel Prize in Physiology or Medicine. From 1902 Carrel performed transplant experiments on dogs. Surgically successful in moving kidneys, hearts and spleens, he was one of the first to identify the problem of rejection, which remained insurmountable for decades. The discovery of transplant immunity by the German surgeon Georg Schöne, various strategies of matching donor and recipient, and the use of different agents for immune suppression did not result in substantial improvement so that organ transplantation was largely abandoned after WWI.[8]

Major steps in skin transplantation occurred during the First World War, notably in the work of Harold Gillies at Aldershot. Among his advances was the tubed pedicle graft, maintaining a flesh connection from the donor site until the graft established its own blood flow. Gillies' assistant, Archibald McIndoe, carried on the work into the Second World War as reconstructive surgery. In 1962 the first successful replantation surgery was performed – re-attaching a severed limb and restoring (limited) function and feeling.

Transplant of a single gonad (testis) from a living donor was carried out in earlyJuly 1926 in Zaječar, Serbia, by a Russian emigré surgeon Dr. Peter Vasil'evič Kolesnikov. The donor was a convicted murderer, one Ilija Krajan, whose death sentence was commuted to 20 years imprisonment and he was led to believe that it was done because he had donated his testis to an elderly medical doctor. Both the donor and the receiver survived, but charges were brought in a court of law by thepublic prosecutor against Dr. Kolesnikov, not for performing the operation, but for lying to the donor.[9]

The first attempted human deceased-donor transplant was performed by the Ukrainiansurgeon Yuri Voronoy in the 1930s;[10][11] rejection resulted in failure. Joseph Murray and J. Hartwell Harrison performed the first successful transplant, a kidney transplant between identical twins, in 1954, because no immunosuppression was necessary for genetically identical individuals.

In the late 1940s Peter Medawar, working for the National Institute for Medical Research, improved the understanding of rejection. Identifying the immune reactions in 1951, Medawar suggested that immunosuppressive drugs could be used. Cortisone had been recently discovered and the more effective azathioprine was identified in 1959, but it was not until the discovery of cyclosporinein 1970 that transplant surgery found a sufficiently powerful immunosuppressive.

Dr. Murray's success with the kidney led to attempts with other organs. There was a successful deceased-donor lung transplant into a lung cancer sufferer in June 1963 by James Hardy inJackson, Mississippi. The patient survived for eighteen daysbefore dying of kidney failure. Thomas Starzl of Denver attempted a liver transplant in the same year but was not successful until 1967.

The heart was a major prize for transplant surgeons. But over and above rejection issues, the heart deteriorates within minutes of death, so any operation would have to be performed at great speed. The development of the heart-lung machine wasalso needed. Lung pioneer James Hardy attempted a human heart transplant in 1964, but when a premature failure of the recipient's heart caught Hardy with no human donor, he used a chimpanzee heart, which failed very quickly. The first success was achieved on December 3, 1967, by Christiaan Barnard in Cape Town, South Africa. Louis Washkansky, the recipient, survived for eighteen days amid what many[who?] saw as a distasteful publicity circus. The media interest prompted a spate of heart transplants. Over a hundred were performed in 1968–1969, but almostall the patients died within sixty days. Barnard's second patient, Philip Blaiberg, lived for 19 months.

It was the advent of cyclosporine that altered transplants from research surgery to life-saving treatment. In 1968 surgical pioneer Denton Cooley performed seventeen transplants, including the first heart-lung transplant. Fourteen of his patients were dead within six months. By 1984 two-thirds of all heart transplant patients survived for five years or more. With organ transplants becoming commonplace, limited only by donors, surgeons moved on to riskier fields, including multiple-organ transplants on humans and whole-body transplant research on animals. On March 9, 1981, the first successful heart-lung transplant took place at Stanford University Hospital. The head surgeon, Bruce Reitz, credited thepatient's recovery to cyclosporine-A.

As the rising success rate of transplants and modern immunosuppression make transplants more common, the need for more organs has become critical. Transplantsfrom living donors, especially relatives, have become increasingly common. Additionally, there is substantive research into xenotransplantation, or transgenic organs; although these forms of transplant are not yet being used in humans, clinical trials involving the use of specific cell types have been conducted with promising results, such as using porcine islets of Langerhans to treat type 1 diabetes. However, there are still many problems that would need to be solved before they would be feasible options in patients requiring transplants.

Recently, researchers have been looking into means of reducing the general burden of immunosuppression. Common approaches include avoidance of steroids, reduced exposure to calcineurin inhibitors, and other means of weaning drugs based on patient outcome and function. While short-term outcomes appear promising, long-term outcomes are still unknown, and in general, reduced immunosuppression increases the risk of rejection and decreases the risk of infection.

Many other new drugs are under development for transplantation.[12]

The emerging field of regenerative medicine promises to solve the problem of organtransplant rejection by regrowing organs in the lab, using the patients' own cells(stem cells or healthy cells extracted from the donor site.)

Timeline of successful transplants[edit]

1823: First skin autograft-transplantation of skin tissue from one location onan individual’s body to another location (Germany)

1905: First successful cornea transplant by Eduard Zirm (Czech Republic) 1908: First skin allograft-transplantation of skin from a donor to a recipient

(Switzerland) 1950: First successful kidney transplant by Dr Richard H. Lawler (Chicago,

U.S.A)[13]

1954:First living related kidney transplant (identical twins) (U.S.A)[14]

1955: First heart valve allograft into descending aorta (Canada) 1962: First kidney transplant from a deceased donor (U.S.A) 1965: Australia’s first successful (living) kidney transplant (Queen Elizabeth

Hospital, SA, Australia)

1966: First successful pancreas transplant by Richard Lillehei and William Kelly (Minnesota, U.S.A.)

1967: First successful liver transplant by Thomas Starzl (Denver, U.S.A.) 1967: First successful heart transplant by Christian Barnard (Cape Town, South

Africa) 1981: First successful heart/lung transplant by Bruce Reitz (Stanford, U.S.A.) 1983: First successful lung lobe transplant by Joel Cooper (Toronto, Canada) 1984: First successful double organ transplant by Thomas Starzl and Henry T.

Bahnson (Pittsburgh, U.S.A.) 1986: First successful double-lung transplant (Ann Harrison) by Joel Cooper

(Toronto, Canada) 1995: First successful laparoscopic live-donor nephrectomy by Lloyd Ratner and

Louis Kavoussi (Baltimore, U.S.A.) 1997: First successful allogeneic vascularized transplantation of a fresh and

perfused human knee joint by Gunther O. Hofmann 1998: First successful live-donor partial pancreas transplant by David

Sutherland (Minnesota, U.S.A.) 1998: First successful hand transplant by Dr. Jean-Michel Dubernard (Lyon,

France) 1999: First successful Tissue Engineered Bladder transplanted by Anthony Atala

(Boston Children's Hospital, U.S.A.) 2005: First successful ovarian transplant by Dr P N Mhatre (Wadia hospital

Mumbai, India) 2005: First successful partial face transplant (France) 2006: First jaw transplant to combine donor jaw with bone marrow from the

patient, by Eric M. Genden Mount Sinai Hospital, New York 2006: First successful human penis transplant (later reversed after 15 days

due to 44-year-old recipient's wife's psychological rejection) (Guangzhou, China) [15][16]

2008: First successful complete full double arm transplant by Edgar Biemer, Christoph Höhnke and Manfred Stangl (Technical University of Munich, Germany)

2008: First baby born from transplanted ovary by James Randerson 2008: First transplant of a human windpipe using a patient’s own stem cells,

by Paolo Macchiarini (Barcelona, Spain)

2008: First successful transplantation of near total area (80%) of face, (including palate, nose, cheeks, and eyelid) by Maria Siemionow (Cleveland, USA)

2010: First full facial transplant, by Dr Joan Pere Barret and team (Hospital Universitari Vall d'Hebron on July 26, 2010 in Barcelona, Spain.)

2011: First double leg transplant, by Dr Cavadas and team (Valencia's HospitalLa Fe, Spain)

2013: First successful entire face transplantation as an urgent life-saving surgery at Maria Skłodowska-Curie Institute of Oncology branch in Gliwice, Poland.[17]

Types of transplant[edit]Autograft[edit]Main article: Autotransplantation

Transplant of tissue to the same person. Sometimes this is done with surplus tissue, or tissue that can regenerate, or tissues more desperately needed elsewhere (examples include skin grafts,vein extraction for CABG, etc.) Sometimes an autograft is done to remove the tissue and then treat it or the person, before returning it (examples include stem cell autograft and storing blood in advance of surgery). In a rotationplasty a distal joint is used to replace a more proximalone, typically a foot and ankle joint is used to replace a knee joint. The patient's foot is severed and reversed, the knee removed, and the tibia joined with the femur.

Allograft and allotransplantation[edit]Main article: Allotransplantation

An allograft is a transplant of an organ or tissue between two genetically non-identical members of the same species. Most human tissue and organ transplants areallografts. Due to the genetic difference between the organ and the recipient, therecipient's immune system will identify the organ as foreign and attempt to destroy it, causing transplant rejection. The risk of transplant rejection can be estimated by measuring the Panel reactive antibody level.

Isograft[edit]A subset of allografts in which organs or tissues are transplanted from a donor toa genetically identical recipient (such as an identical twin). Isografts are

differentiated from other types of transplants because while they are anatomicallyidentical to allografts, they do not trigger an immune response.

Xenograft and xenotransplantation[edit]Main article: Xenotransplantation

A transplant of organs or tissue from one species to another. An example is porcine heart valve transplant, which is quite common and successful. Another example is attempted piscine-primate (fish to non-human primate) transplant of islet (i.e. pancreatic or insular tissue) tissue. The latter research study was intended to pave the way for potential human use, if successful. However, xenotransplantion is often an extremely dangerous type of transplant because of the increased risk of non-compatibility, rejection, and disease carried in the tissue.

Split transplants[edit]Sometimes a deceased-donor organ, usually a liver, may be divided between two recipients, especially an adult and a child. This is not usually a preferred option because the transplantation of a whole organ is more successful.

Domino transplants[edit]In patients with cystic fibrosis, where both lungs need to be replaced, it is a technically easier operation with a higher rate of success to replace both the heart and lungs of the recipient with those of the donor. As the recipient's original heart is usually healthy, it can then be transplanted into a second recipient in need of a heart transplant.[18] Another example of this situation occurs with a special form of liver transplant in which the recipient suffers from familial amyloidotic polyneuropathy, a disease where the liver slowly produces a protein that damages other organs. The recipient's liver can then be transplanted into an older patient for whom the effects of the disease will not necessarily contribute significantly to mortality.[19]

This term also refers to a series of living donor transplants in which one donor donates to the highest recipient on the waiting list and the transplant center utilizes that donation to facilitate multiple transplants. These other transplantsare otherwise impossible due to blood type or antibody barriers to transplantation. The "Good Samaritan" kidney is transplanted into one of the otherrecipients, whose donor in turn donates his or her kidney to an unrelated

recipient. Depending on the patients on the waiting list, this has sometimes been repeated for up to six pairs, with the final donor donating to the patient at the top of the list. This method allows all organ recipients to get a transplant even if their living donor is not a match to them. This further benefits patients belowany of these recipients on waiting lists, as they move closer to the top of the list for a deceased-donor organ. Johns Hopkins Medical Center in Baltimore and Northwestern University's Northwestern Memorial Hospital have received significantattention for pioneering transplants of this kind. [20][21]

In February 2012 the last link in a record sixty-person domino chain of thirty kidney transplants was completed.[22][23]

ABO-incompatible transplants[edit]Main article: ABO-incompatible transplantation

Because very young children (generally under 12 months, but often as old as 24 months[24]) do not have a well-developed immune system,[25] it is possible for them to receive organs from otherwise incompatible donors. This is known as ABO-incompatible (ABOi) transplantation. Graft survival and patient mortality is approximately the same between ABOi and ABO-compatible (ABOc) recipients.[26] Whilefocus has been on infant heart transplants, the principles generally apply to other forms of solid organ transplantation.[24]

The most important factors are that the recipient not have produced isohemagglutinins, and that they have low levels of T cell-independent antigens.[25][27] UNOS regulations allow for ABOi transplantation in children under two years of age if isohemagglutinin titers are 1:4 or below,[28]

[29] and if there is no matching ABOc recipient.[28][29][30] Studies have shown that theperiod under which a recipient may undergo ABOi transplantation may be prolonged by exposure to nonself A and B antigens.[31] Furthermore, should the recipient (forexample, type B-positive with a type AB-positive graft) require eventual retransplantation, the recipient may receive a new organ of either blood type.[24]

[29]

Limited success has been achieved in ABO-incompatible heart transplants in adults,[32] though this requires that the adult recipients have low levels of anti-A or anti-B antibodies.[32] Kidney transplantation is more successful, with similar long-term graft survival rates to ABOc transplants.[29]

Major organs and tissues transplanted[edit]

Main article: Transplantable organs and tissues

Thoracic organs[edit]

Heart  (Deceased-donor only) Lung  (Deceased-donor and living-related lung transplantation) Heart/Lung  (Deceased-donor and Domino transplant)Abdominal organs[edit]

Kidney  (Deceased-donor and Living-Donor) Liver  (Deceased-donor and Living-Donor) Pancreas  (Deceased-donor only) Intestine  (Deceased-donor and Living-Donor) Stomach  (Deceased-donor only) Testis [33] Tissues, cells, fluids[edit]

Hand  (Deceased-donor only), see the first recipient Clint Hallam Cornea  (Deceased-donor only) see the ophthalmologist Eduard Zirm Skin  including Face replant (autograft) and Face transplant (extremely rare) Islets of Langerhans  (Pancreas Islet Cells) (Deceased-donor and Living-Donor) Bone marrow /Adult stem cell (Living-Donor and Autograft) Blood transfusion /Blood Parts Transfusion (Living-Donor and Autograft) Blood vessels  (Autograft and Deceased-Donor) Heart valve  (Deceased-Donor, Living-Donor and Xenograft[Porcine/bovine]) Bone  (Deceased-Donor and Living-Donor)

Types of donor[edit]

Organ donors may be living, or may have died of brain death or circulatory death. Most deceased donors are those who have been pronounced brain dead. Brain dead means the cessation of brain function, typically after receiving an injury (eithertraumatic or pathological) to the brain, or otherwise cutting off blood circulation to the brain (drowning, suffocation, etc.). Breathing is maintained via artificial sources, which, in turn, maintains heartbeat. Once brain death has

been declared the person can be considered for organ donation. Criteria for brain death vary. Because less than 3% of all deaths in the U.S. are the result of braindeath, the overwhelming majority of deaths are ineligible for organ donation, resulting in severe shortages.

Organ donation is possible after cardiac death in some situations, primarily when the patient is severely brain injured and not expected to survive without artificial breathing and mechanical support. Independent of any decision to donate, a patient's next-of-kin may decide to end artificial support. If the patient is expected to expire within a short period of time after support is withdrawn, arrangements can be made to withdraw that support in an operating room to allow quick recovery of the organs after circulatory death has occurred.

Tissue may be recovered from donors who die of either brain or circulatory death. In general, tissues may be recovered from donors up to 24 hours past the cessationof heartbeat. In contrast to organs, most tissues (with the exception of corneas) can be preserved and stored for up to five years, meaning they can be "banked." Also, more than 60 grafts may be obtained from a single tissue donor. Because of these three factors—the ability to recover from a non-heart beating donor, the ability to bank tissue, and the number of grafts available from each donor—tissue transplants are much more common than organ transplants. The American Association of Tissue Banks estimates that more than one million tissue transplants take placein the United States each year.

Living donor[edit]In "living donors", the donor remains alive and donates a renewable tissue, cell, or fluid (e.g. blood, skin), or donates an organ or part of an organ in which the remaining organ can regenerate or take on the workload of the rest of the organ (primarily single kidney donation, partial donation of liver, lung lobe, small bowel). Regenerative medicine may one day allow for laboratory-grown organs, usingpatient's own cells via stem cells, or healthy cells extracted from the failing organs.

Deceased donor[edit]Deceased donors (formerly cadaveric) are people who have been declared brain-dead and whose organs are kept viable by ventilators or other mechanical mechanisms until they can be excised for transplantation. Apart from brain-stem dead donors, who have formed the majority of deceased donors for the last twenty

years, there is increasing use of Donation after Circulatory Death Donors (formerly non-heart-beating donors) to increase the potential pool of donors as demand for transplants continues to grow.[citation needed] Prior to the recognition of brain death in the 1980s, all deceased organ donors had died of circulatory death.These organs have inferior outcomes to organs from a brain-dead donor;[34] however given the scarcity of suitable organs and the number of people who die waiting, any potentially suitable organ must be considered.

Allocation of donated organs[edit]

In most countries there is a shortage of suitable organs for transplantation. Countries often have formal systems in place to manage the process of determining who is an organ donor and in what order organ recipients receive available organs.

The overwhelming majority of deceased-donor organs in the United States are allocated by federal contract to the Organ Procurement and Transplantation Network (OPTN), held since it was created by the Organ Transplant Act of 1984 by the United Network for Organ Sharing or UNOS. (UNOS does not handle donor cornea tissue; corneal donor tissue is usually handled by various eye banks.) Individual regional organ procurement organizations (OPOs), all members of the OPTN, are responsible for the identification of suitable donors and collection of the donated organs. UNOS then allocates organs based on the method considered most fair by the scientific leadership in the field. The allocation methodology varies somewhat by organ, and changes periodically. For example, liver allocation is based partially on MELD score (Model of End-Stage Liver Disease), an empirical score based on lab values indicative of the sickness of the patient from liver disease.

Experiencing somewhat increased popularity, but still very rare, is directed or targeted donation, in which the family of a deceased donor (often honoring the wishes of the deceased) requests an organ be given to a specific person. If medically suitable, the allocation system is subverted, and the organ is given to that person. In the United States, there are various lengths of waiting times due to the different availabilities of organs in different UNOS regions. In other countries such as the UK, only medical factors and the position on the waiting list can affect who receives the organ.

One of the more publicized cases of this type was the 1994 Chester and Patti Szuber transplant. This was the first time that a parent had received a heart

donated by one of their own children. Although the decision to accept the heart from his recently killed child was not an easy decision, the Szuber family agreed that giving Patti’s heart to her father would have been something that she would have wanted.[35][36]

Access to organ transplantation is one reason for the growth of medical tourism.

Reasons for donation and ethical issues[edit]Living related donors[edit]Living related donors donate to family members or friends in whom they have an emotional investment. The risk of surgery is offset by the psychological benefit of not losing someone related to them, or not seeing them suffer the ill effects of waiting on a list.

Paired exchange[edit]

Diagram of an exchange between otherwise incompatible pairs

A "paired-exchange" is a technique of matching willing living donors to compatiblerecipients using serotyping. For example a spouse may be willing to donate a kidney to their partner but cannot since there is not a biological match. The willing spouse's kidney is donated to a matching recipient who also has an incompatible but willing spouse. The second donor must match the first recipient to complete the pair exchange. Typically the surgeries are scheduled simultaneously in case one of the donors decides to back out and the couples are kept anonymous from each other until after the transplant.

Paired exchange programs were popularized in the New England Journal of Medicine article "Ethics of a paired-kidney-exchange program" in 1997 by L.F.

Ross.[37] It was also proposed by Felix T. Rapport [38] in 1986 as part of his initial proposals for live-donor transplants "The case for a living emotionally related international kidney donor exchange registry" in Transplant Proceedings.[39] A paired exchange is the simplest case of a much larger exchange registry program where willing donors are matched with any number of compatible recipients.[40] Transplant exchange programs have been suggested as early as 1970: "A cooperative kidney typing and exchange program.".[41]

The first pair exchange transplant in the U.S. was in 2001 at Johns Hopkins Hospital.[42] The first complex multihospital kidney exchange involving 12 patientswas performed in February 2009 by The Johns Hopkins Hospital, Barnes-Jewish Hospital in St. Louis and Integris Baptist Medical Center in Oklahoma City.[43] Another 12-patient multihospital kidney exchange was performed four weeks later by Saint Barnabas Medical Centerin Livingston, New Jersey, Newark Beth Israel Medical Center and New York-Presbyterian Hospital.[44] Surgical teams led byJohns Hopkins continue to pioneer in this field by having more complex chain of exchange such as eight-way multihospital kidney exchange.[45] In December 2009, a 13 organ 13 recipient matched kidney exchange took place, coordinated through Georgetown University Hospital and Washington Hospital Center, Washington DC.[46]

Paired-donor exchange, led by work in the New England Program for Kidney Exchange as well as at Johns Hopkins University and the Ohio OPOs may more efficiently allocate organs and lead to more transplants.

Good Samaritan[edit]Good Samaritan or "altruistic" donation is giving a donation to someone not well-known to the donor. Some people choose to do this out of a need to donate. Some donate to the next person on the list; others use some method of choosing a recipient based on criteria important to them. Web sites are being developed that facilitate such donation. It has been featured in recent television journalism that over half of the members of the Jesus Christians, an Australian religious group, have donated kidneys in such a fashion.[47]

Compensated donation[edit]See also: Organ theft, Organ sale, and Organ trade

In compensated donation, donors get money or other compensation in exchange for their organs. This practice is common in some parts of the world, whether legal ornot, and is one of the many factors driving medical tourism.[48]

An article by Gary Becker and Julio Elias on "Introducing Incentives in the marketfor Live and Cadaveric Organ Donations"[49] said that a free market could help solve the problem of a scarcity in organ transplants. Their economic modeling was able to estimate the price tag for human kidneys ($15,000) and human livers ($32,000).

In the United States, The National Organ Transplant Act of 1984 made organ sales illegal. In the United Kingdom, the Human Organ Transplants Act 1989 first made organ sales illegal, and has been superseded by the Human Tissue Act 2004.

In 2007, two major European conferences recommended against the sale of organs.[50]

Recent development of web sites and personal advertisements for organs among listed candidates has raised the stakes when it comes to the selling of organs, and have also sparked significant ethical debates over directed donation, "good-Samaritan" donation, and the current U.S. organ allocation policy. Bioethicist Jacob M. Appel has argued that organ solicitation on billboards and the internet may actually increase the overall supply of organs.[51]

Two books, Kidney for Sale By Owner by Mark Cherry (Georgetown University Press, 2005);and Stakes and Kidneys: Why markets in human body parts are morally imperative by James Stacey Taylor: (Ashgate Press, 2005); advocate using markets to increase the supply of organs available for transplantation. In a 2004 journal article Economist Alex Tabarrok argues that allowing organ sales, and elimination of organ donor lists will increase supply, lower costs and diminish social anxiety towards organ markets.[52]

Iran has had a legal market for kidneys since 1988,[53] and the market price is of the order of US$1,200 for the recipient.[54] The Economist [55]  and the Ayn Rand Institute [56]  approve and advocate a legal market elsewhere. They argued that if 0.06% of Americans between 19 and 65 were to sell one kidney, the national waitinglist would disappear (which, the Economist wrote, happened in Iran). The Economistargued that donating kidneys is no more risky than surrogate motherhood, which canbe done legally for pay in most countries.

In Pakistan, 40 percent to 50 percent of the residents of some villages have only one kidney because they have sold the other for a transplant into a wealthy person, probably from another country, said Dr. Farhat Moazam of Pakistan, at a World Health Organization conference. Pakistani donors are offered $2,500 for a kidney but receive only about half of that because middlemen take so much.[57] In Chennai, southern India, poor fishermen and their families sold kidneys after their livelihoods were destroyed by the Indian Ocean tsunami on December 26, 2004.About 100 people, mostly women, sold their kidneys for 40,000–60,000 rupees ($900–$1,350).[58] Thilakavathy Agatheesh, 30, who sold a kidney in May 2005 for 40,000 rupees said, "I used to earn some money selling fish but now the post-surgery stomach cramps prevent me from going to work." Most kidney sellers say that selling their kidney was a mistake.[59]

In Cyprus in 2010 police closed a fertility clinic under charges of trafficking inhuman eggs. The Petra Clinic, as it was known locally, imported women from Ukraineand Russia for egg harvesting and sold the genetic material to foreign fertility tourists.[60] This sort of reproductive trafficking violates laws in the European Union. In 2010 the Pulitzer Center on Crisis Reporting and the magazine Fast Company explored illicit fertility networks in Spain, the United States and Israel.[61][62]

Forced donation[edit]See also: Organ transplants in the People's Republic of China

There have been various accusations that certain authorities are harvesting organsfrom those the authorities deem undesirable, such as prison populations. The WorldMedical Association stated that individuals in detention are not in the position to give free consent to donate their organs.[63] Template:Toter Link  Illegal dissection of corpses is a form of body-snatching and may have taken place to obtain allografts.[64]

According to the Chinese Deputy Minister of Health, Huang Jiefu,[65] Template:Toter Link approximately 95% of all organs used for transplantation are from executed prisoners. The lack of public organ donation program in China is used as a justification for this practice. However, reports in the Chinese media raised concerns if executed criminals are the only source for organs used in transplants.

In October 2007, bowing to international pressure, the Chinese Medical Associationagreed on a moratorium of commercial organ harvesting from condemned prisoners,

but did not specify a deadline. China agreed to restrict transplantations from donors to their immediate relatives.[66][67]

People in other parts of the world are responding to this availability of organs, and a number of individuals (including U.S. and Japanese citizens) have elected totravel to China or India as medical tourists to receive organ transplants which may have been sourced in what might be considered elsewhere to be unethical ways (see later).[68][69][70]

Organ transplantation in different countries[edit]Demographics[edit]Despite efforts of international transplantation societies, it is not possible to access an accurate source on the number, rates and outcomes of all forms of transplantation globally; the best that we can achieve is estimations. This is nota sound basis for the future and thus one of the crucial strategies for the GlobalAlliance in Transplantation is to foster the collection and analysis of global data.

Transplantation of organs in different continents/regions year/ 2000

Kidney

(pmp*)

Liver

(pmp)

Heart

(pmp)

USA 52 19 8

Europe 27 10 4

Africa 11 3.5 1

Asia 3 0.3 0.03

Latin America 13 1.6 0.5

All numbers per million population

Source:[71] Template:Toter Link ,[72] Template:Toter Link

According to the Council of Europe, Spain through the Spanish Transplant Organization led by Dr Rafael Matesanz shows the highest worldwide rate of 35.1[73]

[74] donors per million population in 2005 and 33.8[75] in 2006. In 2011, was 35.3 http://www.agenciasinc.es/Noticias/Espana-alcanza-un-record-historico-de-trasplantes-en-2011

In addition to the citizens waiting for organ transplants in the US and other developed nations, there are long waiting lists in the rest of the world. More than 2 million people need organ transplants in China, 50,000 waiting in Latin America (90% of which are waiting for kidneys), as well as thousands more in the less documented continent of Africa. Donor bases vary in developing nations.

Traditionally, Muslims believe body desecration in life or death to be forbidden, and thus many reject organ transplant.[76] However most Muslim authorities nowadaysaccept the practice if another life will be saved.[77]

In Latin America the donor rate is 40–100 per million per year, similar to that ofdeveloped countries. However, in Uruguay, Cuba, and Chile, 90% of organ transplants came from cadaveric donors. Cadaveric donors represent 35% of donors in Saudi Arabia. There is continuous effort to increase the utilization of cadaveric donors in Asia, however the popularity of living, single kidney donors in India yields India a cadaveric donor prevalence of less than 1 pmp.

Organ transplantation in China has taken place since the 1960s, and China has one of the largest transplant programmes in the world, peaking at over 13,000 transplants a year by 2004.[78]Organ donation, however, is against Chinese tradition and culture,[79][80] and involuntary organ donation is illegal under Chinese law.[81] China's transplant programme attracted the attention of international news media in the 1990s due to ethical concerns about the organs and tissue removed from the corpses of executed criminals being commercially traded for transplants.[82][83][84]

With regard to organ transplantation in Israel, there is a severe organ shortage due to religious objections by some rabbis who oppose all organ donations and others who advocate that a rabbi participate in all decision making regarding a particular donor. One third of all heart transplants performed on Israelis are done in the Peoples' Republic of China; others are done in Europe. Dr. Jacob Lavee, head of the heart-transplant unit, Sheba Medical Center, Tel Aviv, believesthat "transplant tourism" is unethical and Israeli insurers should not pay for it.The organization HODS (Halachic Organ Donor Society) is working to increase knowledge and participation in organ donation among Jews throughout the world.[85]

Transplantation rates also differ based on race, sex, and income. A study done with patients beginning long term dialysis showed that the sociodemographic barriers to renal transplantation present themselves even before patients are on the transplant list.[86] For example, different groups express definite interest and complete pretransplant workup at different rates. Previous efforts to create fair transplantation policies had focused on patients currently on the transplantation waiting list.

Comparative costs[edit]One of the driving forces for illegal organ trafficking and for “transplantation tourism” is the price differences for organs and transplant surgeries in differentareas of the world. According to the New England Journal of Medicine, a human kidney can be purchased in Manila for $1000–$2000, but in urban Latin America a kidney may cost more than $10,000. Kidneys in South Africa have sold for as high as $20,000. Price disparities based on donor race are a driving force of attractive organ sales in South Africa, as well as in other parts of the world.

In China, a kidney transplant operation runs for around $70,000, liver for $160,000, and heart for $120,000 [87] Template:Toter Link . Although these prices arestill unattainable to the poor, compared to the fees of the United States, where akidney transplant may demand $100,000, a liver $250,000, and a heart $860,000, Chinese prices have made China a major provider of organs and transplantation surgeries to other countries.

In India, a kidney transplant operation runs for around as low as $5000.

Safety[edit]In the United States of America, tissue transplants are regulated by the U.S. Foodand Drug Administration (FDA) which sets strict regulations on the safety of the transplants, primarily aimed at the prevention of the spread of communicable disease. Regulations include criteria for donor screening and testing as well as strict regulations on the processing and distribution of tissue grafts. Organ transplants are not regulated by the FDA.[citation needed]

In November 2007, the CDC reported the first-ever case of HIV and Hepatitis C being simultaneously transferred through an organ transplant. The donor was a 38-year-old male, considered "high-risk" by donation organizations, and his organs transmitted HIV and Hepatitis C to four organ recipients. Experts say that the

reason the diseases did not show up on screening tests is probably because they were contracted within three weeks before the donor's death, so antibodies would not have existed in high enough numbers to detect. The crisis has caused many to call for more sensitive screening tests, which could pick up antibodies sooner. Currently, the screens cannot pick up on the small number of antibodies produced in HIV infections within the last 90 days or Hepatitis C infections within the last 18–21 days before a donation is made.

NAT (nucleic acid testing) is now being done by many organ procurement organizations and is able to detect antibodies for HIV and Hepatitis C within seven to ten days of exposure to the virus.

Organ transplant laws[edit]Both developing and developed countries have forged various policies to try to increase the safety and availability of organ transplants to their citizens. Brazil, France, Italy, Poland and Spain have ruled all adults potential donors with the “opting out” policy, unless they attain cards specifying not to be. However, whilst potential recipients in developing countries may mirror their more developed counterparts in desperation, potential donors in developing countries do not. The Indian government has had difficulty tracking the flourishing organ black market in their country and have yet to officially condemnit. Other countries victimized by illegal organ trade have implemented legislativereactions. Moldova has made international adoption illegal in fear of organ traffickers. China has made selling of organs illegal as of July 2006 and claims that all prisoner organ donors have filed consent. However, doctors in other countries, such as the United Kingdom, have accused China of abusing its high capital punishment rate. Despite these efforts, illegal organ trafficking continues to thrive and can be attributed to corruption in healthcare systems, which has been traced as high up as the doctors themselves in China, Ukraine, and India, and the blind eye economically strained governments and health care programs must sometimes turn to organ trafficking. Some organs are also shipped toUganda and the Netherlands. This was a main product in the triangular trade in 1934[citation needed].

Starting on May 1, 2007, doctors involved in commercial trade of organs will face fines and suspensions in China. Only a few certified hospitals will be allowed to

perform organ transplants in order to curb illegal transplants. Harvesting organs without donor's consent was also deemed a crime.[88]

On June 27, 2008, Indonesian, Sulaiman Damanik, 26, pleaded guilty in Singapore court for sale of his kidney to CK Tang's executive chair, Tang Wee Sung, 55, for 150 million rupiah (S$ 22,200). The Transplant Ethics Committee mustapprove living donor kidney transplants. Organ trading is banned in Singapore and in many other countries to prevent the exploitation of "poor and socially disadvantaged donors who are unable to make informed choices and suffer potential medical risks." Toni, 27, the other accused, donated a kidney to an Indonesian patient in March, alleging he was the patient's adopted son, and was paid 186 million rupiah (20,200 USD). Upon sentence, both would suffer each, 12 months in jail or 10,000 Singapore dollars (7,600 USD) fine.[89][90]

In an article appearing in the Econ Journal Watch, April 2004.[52] economist Alex Tabarrok examined the impact of direct consent laws on transplant organ availability. Tabarrok found that social pressures resisting the use of transplantorgans decreased over time as the opportunity of individual decisions increased. Tabarrok concluded his study suggesting that gradual elimination of organ donationrestrictions and move to a free market in organ sales will increase supply of organs and encourage broader social acceptance of organ donation as a practice.

Ethical concerns[edit]Main article: Ethics of organ transplantation

The existence and distribution of organ transplantation procedures in developing countries, while almost always beneficial to those receiving them, raise many ethical concerns. Both the source and method of obtaining the organ to transplant are major ethical issues to consider, as well as the notion of distributive justice. The World Health Organization argues that transplantations promote health, but the notion of “transplantation tourism” has the potential to violate human rights or exploit the poor, to have unintended health consequences, and to provide unequal access to services, all of which ultimately may cause harm. Regardless of the “gift of life”, in the context of developing countries, this might be coercive. The practice of coercion could be considered exploitative of the poor population, violating basic human rights according to Articles 3 and 4 of the Universal Declaration of Human Rights. There is also a powerful opposing view, that trade in organs, if properly and

effectively regulated to ensure that the seller is fully informed of all the consequences of donation, is a mutually beneficial transaction between two consenting adults, and that prohibiting it would itself be a violation of Articles3 and 29 of the Universal Declaration of Human Rights.

Even within developed countries there is concern that enthusiasm for increasing the supply of organs may trample on respect for the right to life. The question ismade even more complicated by the fact that the "irreversibility" criterion for legal death cannot be adequately defined and can easily change with changing technology.[91]

Artificial organ transplantation[edit]Surgeons in Sweden performed the first implantation of a synthetic trachea in July2011, for a 36-year-old patient who was suffering from cancer. Stem cells taken from the patient's hip were treated with growth factors and incubated on a plasticreplica of his natural trachea.[

http://aku122.blogspot.com/2008/10/pembedahan-jantung-bersejarah-di.html

Monday, October 20, 2008Pembedahan Jantung Bersejarah di Malaysia 2007

Pembedahan Jatung Hui YeeKuala Lumpur 5 Okt. -

Dalam tempuh 36 jam antara pukul 8 malam Rabu lalu hingga 8 pagi hari ini, Pasukan Perubatan Institu Jantung Negara (IJN) telah menlakukan pembedahan bersejarah selama 22 jam untuk menyelamatkan nyawa Tee Hui Yee, gadis yang bergantung nyawa kepada jantung mekanikal sejak setahun lalu.Beberapa jam selepas selesai menjalani pembedahan pemindahan jantung yang didermakan oleh keluarga remaja Melayu berusia 15 tahun dari Sitiwan

pada pukul 9.05 pagi semalam tubuh Hui Yee menunjukkan penolakan terhadap jantung tersebut.Doktor -doktor IJN kemudian memaklumkan ada keluarga lelaki mati otak di Johor bersedia menderma jantung dan organ anak mereka kepada Hui Yee di Hospital Sultanah Aminah Johor.Jika pada malam sebelumnya, pasukan perubatan IJN berkerjar ke Ipoh yang terletak 200 kilometer dari Kuala Lumpur

untuk mengeluarkan jantung remaja dari Sitiawan, malam tadi mereka terbang pula 360 kilometer ke johor Baharu dalam misi untuk menyelemat Hui Yee.

ia merupakan pembedahan mengeluarkan organ penderma berasingan yang ke dua dalam tenpuh 24 jam bagi memberi harapan baru kepada Hui Yee. Apabila jantung baru dari Johor Baharu itu tiba jam 1.30 pagi ini, pasukan perubatan itu terpaksa melakukan pembedahan sekali lagi selama 7 jam keatas Hui Yee untuk memindahkan jantung penderma itu kedada Hui Yee.Ketua pakar bedah kardiotorasik, IJN Datuk Dr Mohd Azahari Yakub berkata, pembedahan pemindahan kedua itu terpaksa dilakukan setelah sistem tubun Hui Yee tidak dapat menerimajantung pertama." setelah pembedahan pemindahan pertama, kami dapati jantung itu kurang memuaskan dan keadaannya kurangstabil, walupun semasa diambil jantung penderma itu dalam keadaan baik.

"Bersama dengan Pengarah Klinikal Unit Pemindahan Jantung Dan Paru-Paru IJN, Dr Mohamed Ezani Md Taib, Mohd Azahari mengetui pasukan perubatan yang melakukan kedua-dua pembedahan pemindahan keatas Hui Yee.Beliau memberi tahu ,selepas pemindahan kedua Hui Yee kini berada di unit rawatan Rapi (ICU) dan dalam keadaan stabil dengan jantung mengalami mengecutan manakala kaedaan dan tekanan darahnya memuaskan."

Jantungnya berfungsi amat baik dan memerlukan sokongan yang berkurangan, namunbelaiu kekal kritikal khusunya dalam tempuh dua hingga 3 hari ini," jelas Dr Mohd Azahari[ Kita salute dan tabit hurmat kepada Pasukan Perubatan IJN yang melakukan pembedahan yang bersejarah bagi meyelamat seorang insan. Sama-samalah kita berdoa mudah-mudahan Dr Azahari , Dr Mohd Ezani dan pasukan perubatan lainnya diberkati , dirahmati dan dipanjangkan umur -Amin ]

http://www.utusan.com.my/utusan/info.asp?y=1999&dt=0404&pub=Utusan_Malaysia&sec=Muka_Hadapan&pg=fp_02.htm

Pembedahan pemindahan hati Hafizam - Afiq berjaya

AFIQ menerima pemeriksaan lanjut seorang pakar bedah sementara Hafizam (gambar kanan) menggenggamerat tangan ibunya Fatimah Abdul selepas kedua-duanya selamat menjalani pembedahan pemindahan hati di Pusat Perubatan Subang Jaya semalam. - Gambar IZHAM JAAFAR.

PETALING JAYA 3 April - Pembedahan pemindahan hati Wan Mohd. Hafizam Wan Ismail, 23, untuk didermakan kepada Mohd. Afiq Iqmal, 14 bulan hari ini berjaya dan kedua-duanya kini berada dalam keadaan stabil.

Pakar Bedah Pusat Perubatan Subang Jaya (SJMC), Dr. K.C. Tan berkata, Hafizam selamat menjalani pembedahan dan keluar dari dewan pembedahan kira-kira pukul 5 petang manakala Afiq keluar dari dewan pembedahan kira-kira pukul 7.40 malam.

''Pembedahan ini bagus dan peluangnya bagus dan kedua-duanya kini dalam keadaan stabildan mereka kini dimasukkan ke Unit Rawatan Rapi (ICU) untuk penyeliaan rawatan seterusnya,'' katanya kepada pemberita di sini malam ini.

Beliau berkata, Hafizam dan Afiq kini sudah pun sedar malah hati Afiq yang baru sudah mula berfungsi.

Afiq perlu dimasukkan ke ICU selama seminggu lagi untuk penyeliaan rawatan seterusnya.Hafizam kini dilaporkan sudah boleh bangun dan beliau akan pulih sepenuhnya dalam tempoh seminggu.

''Penentuan sama ada terdapat komplikasi ke atas Afiq dapat diketahui dalam tempoh seminggu ini,'' katanya.

Dalam pembedahan pemindahan hati yang pertama kali dilakukan di negara ini melibatkan bukan keluarga dilakukan oleh sepasukan sembilan doktor pakar yang diketuai oleh Dr. K.C. Tan. Pembedahan itu mengambil masa hampir sembilan jam.

Pembedahan pemindahan hati ini adalah kali ke 25 yang dilakukan oleh SJMC sejak 1995, bagaimanapun keunikan pembedahan kali ini ia yang pertama melibatkan bukan keluarga.

Hafizam dibawa ke dewan bedah mulai pukul 7.30 pagi dan proses pembedahan bermula kira-kira jam 8.30 pagi.

Hafizam dibawa keluar dari dewan bedah tepat pada pukul 5 petang dan terus dibawa ke ICU untuk menjalani rawatan lanjut. Sementara, Afiq dilihat memasuki dewan bedah pada pukul 9 pagi.

Kejayaan pembedahan itu disambut dengan penuh kesyukuran dan kegembiraan oleh kedua-dua keluarga yang berada di pusat perubatan sejak awal pagi.

Bapa Afiq, Muhammad Zaini Drahim berkata, beliau terharu kerana kedua-duanya selamat dalam pembedahan tersebut yang diharap membawa sinar baru kepada kehidupan anaknya.

''Saya mengucapkan terima kasih atas pengorbanan Hafizam dan atas doa rakyat Malaysia seluruhnya,'' ujarnya. Ibu Hafizam, Fatimah Abdul, 48, turut bersyukur kerana pembedahan itu selamat yang sekali gus menyempurnakan pengorbanan anaknya.

''Hafizam begitu terharu akhirnya pengorbanannya menjadi kenyataan,'' katanya terharu selepas melawat keadaan terbaru Hafizam malam ini.

Penderitaan Afiq yang menghidap penyakit hati yang serius mendapat perhatian Utusan Malaysia. Pembedahan menelan perbelanjaan kira-kira RM300,000.

http://www.bicaradariaku.com/2013/04/sejarah-pemindahan-organ-di-malaysia.html

SEJARAH PEMINDAHAN ORGAN DI MALAYSIA

 

Pemindahan organ pertama di Malaysia ialah pada 15.12.1975, apabilaHospital Besar Kuala Lumpur(HBKL) berjaya memindahkan buah pinggangAugustus Sittin kepada abangnya Martin Rinyeb yang mengalami kerosakkanbuah pinggang. 

Pemindahan jantung pertama di Malaysia pula ialah pada 18.12.1997. Iadiketuai oleh Dato’ Dr Yahya Awang terhadap Sathurugnam Ramakrisnan diInstitut Jantung Negara (IJN)

 

INFO TAMBAHAN

Permintaan untuk pemindahan buah pinggang dan lain-lain organ terlalutinggi di Malaysia. Setakat ini(berdasarkan kenyataan Pengurus Pusat SumberTransplan Nasional sebagaimana yang disiarkan di dalam Mingguan Malaysia bertarikh21.10.2012) terdapat 16,479 orang pesakit yang sedang menunggu pemindahanorgan. Masalah utama ialah Malaysia kekurangan penderma organ. Mengikutnisbah bilangan penderma organ di Malaysia ialah 7 orang daripada sejutarakyat Malaysias( 7: 1000000.00)

http://e-kiosk.ikim.gov.my/downloadarticle.asp?id=489

http://www.infosihat.gov.my/infosihat/projekkhas/dermaOrgan.php

Derma Organ

Anugerah Kehidupan Yang Tidak Ternilai

Isu mengenai kematian serta pendermaan organ adalah sesuatu yang sukar untukdiperkatakan. Apatah lagi untuk mereka yangkehilangan orang yang tersayang. Ia juga merupakanperkara yang rumit bagi kakitangan perubatan yangsentiasa berusaha untuk menyelamatkan nyawaseseorang pesakit. Keputusan untuk mengizinkanpenderma organ dan tisu seseorang yang disayangiapabila beliau meninggal dunia, bukan sesuatu yangmudah. Ia membangkitkan beberapa kemusykilan bagi

keluarga si mati. Untuk meringankan beban mental keluarga kita semasakematian, haruslah kita membuat pengakuan persetujuan untuk menderma organ dantisu semasa hayat kita.

Dengan mendaftarkan diri kepada Daftar Penderma Organ Nasional, anda akanmembenarkan organ dan tisu anda digunakan bagi tujuan transplan, selepas andameninggal dunia. Ini akan mengubahkan kehidupan beberapa orang yang mengalamikegagalan organ supaya menjadi lebih selesa dan sempurna serta dapatmenyelamatkan nyawa mereka daripada maut.

Kita sedar bahawa isu pendermaan organ dan tisu adalah suatu isu yangmenimbulkan banyak persoalan. Oleh itu, berikut adalah penjelasan kepadabeberapa persoalan yang sentiasa ditimbulkan.

Siapakah Yang Layak Menjadi Penderma ?

Sesiapa pun,sama ada tua ataupun muda boleh mendaftar segagai penderma organdan tisu. Walau bagaimanapun mereka yang berusia kurang dari 18 tahun perlumendapat kebenaran ibu bapa atau penjaga terlebih dahulu.

Apakah Itu Pendermaan Organ?

Ia adalah proses mendermakan bahagian tubuh badan seseorang untuk transplanselepas dia meninggal dunia.

Transplantasi (Pemindahan Organ) adalah suatu pembedahan yang melibatkanpertukaran organ atau tisu yang mengalami kegagalan fungsinya dengan organatau tisu yang berfungsi dengan lebih memuaskan daripada seseorang pendermayang telah meninggal dunia. Dengan cara ini, maka kehidupan penerima organatau tisu itu akan menjadi lebih selesa dan sempurna serta nyawanya akanterselamat. Pendermaan organ dan tisu adalah satu amalan kemanusiaan yangmulia.

Apakah Organ dan Tisu Yang Boleh Didermakan?

Pada umumnya organ-organ yang boleh didermakan adalah buah pinggang, jantung,hati (heper), paru-paru dan pankreas. Tisu-tisu yang boleh didermakan adalahmata, tulang, kulit dan injap jantung. Ini bermakna, seseorang penderma akandapat mengubah kehidupan serta menyelamatkan beberapa orang pesakit.

Bilakah Organ dan Tisu Si Penderma Itu Diperoleh?

Proses perolehan organ dan tisu daripada tubuh seseorangpenderma itu hanya akan dilakukan apabila kematian telahdisahkan oleh dua orang doktor dengan pengesahan kematianseseorang penderma itu adalah bebas dan tiada kaitan dengan

pemindahan organ dan tisu.

Apakah Perbezaan Rawatan Jika Diketahui Anda Adalah Seorang Penderma?

Tidak! doktor-doktor yang merawat anda akan berusaha sedaya mungkin denganmengambil semua tindakan serta langkah yang diperlukan untuk menyelamatkannyawa anda. Persoalan mengenai pendermaan organ dan tisu akan dibincangkandengan waris anda hanya selapas kematian telah disahkan

Adakah Terdapat Bantahan Daripada Sudut Agama?

Tiada! kebanyakan agama di seluruh dunia seperti Islam, Kristian, Buddha,Hindu dan Sikh mengiktiraf pendermaan organ dan tisu sebagai satu amalan yangmulia.

Bagaimana Organ Pendermaan Itu Dipindahkan?

Proses pemindahan organ dan tisu membabitkan suatu pembedahanyang bersih dan suci hama. Pembedahan ini dijalankan di dewanbedah hospital oleh pakar bedah yang berpengalaman. Perolehanorgan serta tisu seseorang penderma ini tidak akan menjejaskanrupa dan bentuk tubuh badannya. Selepas organ dan tisudiperolei luka pembedahan itu akan dijahit dengan sempurna dan jenazah sipenderma ini tidak akan mengalami apa-apa kecacatan fizikal. Segala prosewpembedahan pemindahan ini dijalankan dengan rasa penuh hormat dan tertibseperti mana pembedahan-pembedahan biasa

Bagaimana Jika Anda Berubah Fikiran Menderma?

Pendermaan organ adalah suatu niat yang tulus ikhlas dan anda berhak untukmembatalkan hasrat ini pada bila-bila masa. Tiada sesiapa pun yang dipaksauntuk menderma organ dan menukar fikiran untuk tidak menderma organ dan tisu.Anda hanya perlu memberitahu keluarga anda mengenainya dan memulangkan kadpenderma organ anda kepada kami.

Adakah Proses Pendermaan Organ Akan Melambatkan Urusan Pengkebumian Jenazah?

Tidak! urusan pengkebumian boleh dijalankan seperti biasa. Selepas organ dantisu diperoleh daripada tubuh penderma maka jenazah akan dibersih, dikhafandan dipulangkan kapada waris penderma secepat mungkin. Proses perolehan organdan tisu tidak akan menjejaskan adat pengkebumian seperti upacara penghormatankepada jenazah.

Bagaimanakah Anda Berhajat Untuk Menjadi Seorang Penderma Organ?

Anda perlu mengisi borang akaun penderma dan kad penderma. Borang yang telahdilengkapkan perlu dihantar kepada Pusat Sumber Transplan Nasional, sementarakad penderma anda hendaklah disimpan di dalam dompet dan dibawa bersama andapada setiap masa.

Anda Dinasihatkan Untuk Memaklumkan Hasrat Anda Untuk Menjadi Seorang PendermaOrgan Dan Tisu Kepada Keluarga Anda?

Ini akan memudah serta melicinkan proses mendapatkan keizinan perolehan organdan tisu selepas kematian anda kelak.

Mati Otak dan Pendermaan Organ

Pemindahan organ hanya akan dilakukan setelah pesakit disahkan mati otak. Bagimelaksanakan pemindahan ini anggota perubatan perlu mendapatkan kebenaranterlebih dahulu daripada ahli keluarga terdekat penderma. Pembedahanpemindahan organ hanya akan dilakukan setalah mendapat kebenaran ahli keluargapesakit yang mengalami mati otak tersebut.

Apakah yang dikatakan MATI OTAK?

Mati otak ialah keadaan tiada pengedaran darah dan oksigen ke otak yangmenyababkan keseluruhan otak (termasuk batang otak iaitu penghidupan sepertipernafasan dan denyutan janting) tidak lagi berfungsi. Kehilangan fungsi otakini tidak boleh dipulihkan.

http://pmr.penerangan.gov.my/index.php/sosial/7509-fakta-mengenai-pendermaan-organ.html

FAKTA MENGENAI PENDERMAAN ORGAN 

 

 

Antara Organ yang boleh diderma

Organ tisu yang boleh didermakan•    Jantung•    Paru-paru•    Hati•    Buah Pinggang•    Pankreas 

Tisu •    Injap Jantung•    Mata•    Tulang•    Kulit•    Usus•    Pembuluh darah•    Muka

Jenis Penderma/Penderma Hidup•    Penderma hidup hanya boleh mendermakan satu buah pinggang atau sebahagian hati dan sum-sum tulang saja.•    Terhad kepada  mereka yang mempunyai  pertalian darah atau mereka yang mempunyai hubungan emosi seperti suami isteri saja.

Pendermaan semasa hidup terbahagi kepada dua jenis iaitu:•    Pendermaan ada pertalian saudara•    Pendermaan tiada talian saudaraPendermaan kadaverik:•    Penderma Kadaverik ialah penderma yang sudah meninggal dunia.

Pendermaan jenis ini amat digalakkan dan diutamakan:•    Ia tidak memberikan risiko kepada penderma

Penderma kadaverik terbahagi kepada dua kategori:•    Kematian otak penderma adalah penderma yang disahkan meninggal dunia di hospital. Matiotak ialah satu keadaan apabila tiada pengedaran darah dan oksigen ke otak yang menyebabkankeseluruhan otak yang mengawal aktiviti kehidupan seperti pernafasan dan degupan jantung mati. •    Ini boleh berlaku akibat kecederaan otak yang menyebabkan otak membengkak ataupun

pendarahan dalam kepala yang teruk, pendarahan spontan akibat pecah urat saluran darah yangtidak normal atau tekanan darah yang tinggi, strok yang teruk, barah otak dan seumpamanya.•    Hanya penderma yang kematian otak boleh mendermakan otak organ dan tisu seperti jantung, paru-paru, hati dan buah pinggang (ginjal), mata a(kornea), tulang dan kulit.•    Kematian normal di mana seseorang itu disahkan mati kerana jantung berhenti berdegup dan penderma ini hanya boleh mendermakan tisu sahaja. •    Hanya mereka yang meninggal di hospital boleh mendermakan semua jenis tisu. Bagi mereka yang meninggal di rumah, mereka hnaya boleh mendermakan mata (kornea).  Pihak keluarga perlu menghubungi hospital kerajaan terdekat bagi tujuan perolehan tisu berkenaan di rumah.

http://www.bicaradariaku.com/2013/04/sejarah-pemindahan-organ-di-

malaysia.html

Pemindahan organ pertama di Malaysia ialah pada15.12.1975, apabila Hospital Besar Kuala

Lumpur(HBKL) berjaya memindahkan buah pinggangAugustus Sittin kepada abangnya Martin Rinyebyang mengalami kerosakkan buah pinggang. 

Pemindahan jantung pertama di Malaysia pulaialah pada 18.12.1997. Ia diketuai oleh Dato’ DrYahya Awang terhadap Sathurugnam Ramakrisnan diInstitut Jantung Negara (IJN)