Kelebihan Katalis Organik :

- Tersedia secara komersial dalam jumlah yang besar (mudah diperoleh).- Low cost dan low toxicity.- Tidak sensitif terhadap kelembaban dan oksigen.- Tidak mengandung unsur metal, sehingga dapat memberi kontribusi dalam green

chemistry (ramah lingkungan).

Kekurangan Katalis Organik :

- Memerlukan jumlah yang lebih banyak (dalam % mol) untuk bereaksi, terutama pada ikatan kovalen. (contohnya : untuk reaksi katalisis prolin membutuhkan 20-30% mol).

Sumber :

Wikipedia. Catalysis. en.wikipedia.org/wiki/Catalysis

Wikipedia. Organocatalyst. en.wikipedia.org/wiki/Organocatalysis

Anonim. Organocatalysis. www.organic-chemistry.org/topics/organocatalysis.shtm

Organocatalysis[edit]Main article: Organocatalysis

Whereas transition metals sometimes attract most of the attention in the study of catalysis, small organic molecules without metals can also exhibit catalytic properties, as is apparent from the fact that many enzymes lack transition metals. Typically, organic catalysts require a higher loading (amount of catalyst per unit amount of reactant, expressed in mol% amount of substance) than transition metal(-ion)-based catalysts, but these catalysts are usually commercially available in bulk, helping to reduce costs. In the early 2000s, these organocatalysts were considered "new generation" and are competitive to traditional metal(-ion)-containing catalysts. Organocatalysts are supposed to operate akin to metal-free enzymes utilizing, e.g., non-covalent interactions such as hydrogen bonding. The discipline organocatalysis is divided in the application of covalent (e.g., proline,DMAP) and non-covalent (e.g., thiourea organocatalysis) organocatalysts referring to the preferred catalyst-substrate binding and interaction, respectively.

(en.wikipedia.org/wiki/Catalysis)

Organocatalysis offers several advantages. There is no need for metal-based catalysis thus making a contribution to green chemistry. In this context, simple organic acids have been used as catalyst for the modification of cellulose in water on multi-ton scale.[9] When the organocatalyst is chiral an avenue is opened to asymmetric catalysis, for example the use of proline in aldol reactions,

Organocatalysts which display secondary amine functionality can be described as performing either enamine catalysis (by forming catalytic quantities of an active enamine nucleophile) or iminium catalysis (by forming catalytic quantities of an activated iminium electrophile). This mechanism is typical for covalent organocatalysis. Covalent binding of substrate normally requires high catalyst loading (for proline-catalysis typically 20-30 mol%). Noncovalent interactions such as hydrogen-bonding facilitates low catalyst loadings (down to 0.001 mol%).

(en.wikipedia.org/wiki/Organocatalysis)

Organocatalysis uses small organic molecules predominantly composed of C, H, O, N, S and P to accelerate chemical reactions. The advantages of organocatalysts include their lack of sensitivity to moisture and oxygen, their ready availability, low cost, and low toxicity, which confers a huge direct benefit in the production of pharmaceutical intermediates when compared with (transition) metal catalysts.

(www.organic-chemistry.org/topics/organocatalysis.shtm)