8/13/2019 HIPERTENSI - Farmakoterapi

1/9

10/26/20

HIPERTENSI

DEFINISI

Blood pressure:

is the pressure of the blood against the walls of thearteries.

results fro two for!es. "ne is !reated b# the heart as it pups blood into the arteries

and through the !ir!ulator# s#ste.

The other is the for!e of the arteries as the# resist the bloodflow.

Te$anan darah

S#stoli! blood pressure is a easure of bloodpressure while the heart is beating

Diastoli! pressure is a easure of blood pressurewhile the heart is rela%ed& between heartbeats.

TEKANAN DARAH

CARDIAC OUTPUT RESISTENSI PERIFER

8/13/2019 HIPERTENSI - Farmakoterapi

2/9

10/26/20

HIPERTENSI

H#pertension is defined b# persistent ele'ation ofarterial blood pressure (BP).

The Se'enth Report of the *oint National +oittee

on the Dete!tion& E'aluation& and Treatent of HighBlood Pressure (*N+ ,) !lassifies adult BP

isolated s#stoli! h#pertension: Patients with diastoli!blood pressure (DBP) 'alues -/ Hg ands#stoli! blood pressure (SBP) 'alues 012/ Hg

3 h#pertensi'e !risis (BP 415/617/ Hg) a# be!ategori8ed as either :

a h#pertensi'e eergen!# (e%tree BP ele'ation

with a!ute or progressing target organ daage) or

a h#pertensi'e urgen!# (se'ere BP ele'ation without

a!ute or progressing target organ in9ur#)

PRE3;ENSI D3N EPIDE

8/13/2019 HIPERTENSI - Farmakoterapi

3/9

10/26/20

P3T"FISI";"=I

8/13/2019 HIPERTENSI - Farmakoterapi

4/9

10/26/20

"

8/13/2019 HIPERTENSI - Farmakoterapi

5/9

8/13/2019 HIPERTENSI - Farmakoterapi

6/9

10/26/20

3lgorita terapi hipertensi

Ora) antihypertensi8e .r/gs9

C)ass Dr/g ,Tra.e Na(e- Us/a) .se range in (g5.ay ,Dai)y Fre:/en*y-

ACE inhi4itrs

bena&e#$il '(otensin)* 10+%0 '1+2*

,a#to#$il 'Ca#oten)* 25+100 '2*

enala#$il '-asote,)* 2.5+%0 '1+2*osino#$il 'Mono#$il* 10+%0 '1*

lisino#$il '$iniil est$il)* 10+%0 '1*oei#$il '4nias,* 7.5+30 '1*

#e$indo#$il 'A,eon* %+8 '1+2*

uina#$il 'A,,u#$il* 10+%0 '1*

$ai#$il 'Alta,e* 2.5+20 '1*

t$andola#$il 'Mai* 1+% '1*

Angitensin II antagnists

,andesa$tan 'Ata,and* 8+32 '1*

e#$osa$tan 'eetan* %00+800 '1+2*i$besa$tan 'Aa#$o* 150+300 '1*

losa$tan 'Co&aa$* 25+100 '1+2*

olesa$tan 'eni,a$* 20+%0 '1*telisa$tan 'Mi,a$dis* 20+80 '1*alsa$tan 'ioan* 80+320 '1*

C)assii*atinC)assii*atin

Ca)*i/( AntagnistsCa)*i/( Antagnists;eneratin3

First Se*n. Thir.

8/13/2019 HIPERTENSI - Farmakoterapi

7/9

10/26/20

Pen#e$at reseptor angiotensin II (3RB)

Efe$ angiotensin II: 'aso$onstri$si& pelepasanaldosteron& a$ti'asi sipati$& pelepasan horon

antidiureti$

Beta blo!$er

Ad$enose#to$ beta1 dan beta2 te$dist$ibusi di selu$uh tubuh

eta 1:

te$da#at ban"a di

8/13/2019 HIPERTENSI - Farmakoterapi

8/9

10/26/20

Reserpin

8/13/2019 HIPERTENSI - Farmakoterapi

9/9

10/26/20

*E;3S3N ISTI;3H BERI>T

Pheo!hroo!#toa

"rtostati$ hipotensi +hushing s#ndroe

3theros$lerosis

Hirsutise