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Shape GGGCCCAUAGCUCAGUGGUAGAGUGCCUCCUUUGCAAGGAGGAUGCCCUGGGUUCGAAUCCCAGUGGGUCCA

[] (((((((((((((((.((((.....(((((((...))))))).))))))))))).........)))))))). -35.9 kcal/mol[[][]] ((((((((.....((.((((.....(((((((...))))))).))))))(((.......))).)))))))). -32.2 kcal/mol

[[][][]] ((((((...((((.......)))).(((((((...))))))).....(((((.......))))).)))))). -31.7 kcal/mol

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CGU

CCCCUCGGUAAUGGC

GAA

UGGGACCC

A C AAA

UCUC

UCUA

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Validation of clustering results of HDV ribozyme

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Validation of clustering results of HDV ribozyme

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paRNAss - Morphological Distance Plot of T4 td gene intron

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paRNAss - Tree Distance Plot of T4 td gene intron

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UG

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AA

CU

UGC

UU U A

ACAAGUUG

GA G A U A

U AG U C

UG

C UC

UG

CA

UGG U

GAC

AU

GC

AGC U G G A

U AUA

AUUCCGG

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UAAGAUUAACGAC

CUUAUCU G A

ACAUAA

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C

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AGGGUCAAG U

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UG

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CUUAUCU G A

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UUU

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A G AU

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UG

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AUUCCGG

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ACGA

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UACA

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AA

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UG

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UG

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U AUA

AUUCCGG

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ACGA

CC

UU

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C U G A A C A UA

AUGC

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Validation of clustering results of T4 td gene intron

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Validation of clustering results of T4 td gene intron

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Validation of clustering results of T4 td gene intron

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paRNAss - Morphological Distance Plot of HIV2 leader

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paRNAss - Tree Alignment Distance Plot of HIV2 leader

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GG

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GA

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GAUUG

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CCC

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CU

AG

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UC

CC

UG

CU

AG A

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CU

CA

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GC

C G G U G C U G GG

CA

GA

CG

GC

CCCACGCUUGCUUGCUUAAA

AACC

UCUUAA

UAAA

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A GA A G C A A GUU A A G U G U G

UGC U C C C A U C U C U C C UAG U CGCCGCCU

G

GUCAUUCGGUGUUCACCUGAGUAACAAG

ACCCUG

GUC

U

GUUAGGA

CC

C UUCUUGCUUUGG

GA A

ACCGAGGCAGGAA A

AU

CCCUAGCA G

GUU

G GC

GC

C

UGAA

CAGGGA

CUUGA

AGA

AG

AC

UG A

GAA

GU

CU

U

GGAACACGG

CUGAGUGAAG

GCAG

UAAG

GGCGGCAG

G AACAAAC C A C

GAC

G G AG U

GCUCCU A G AAAGG

C G CGGG C C

G AG G

UAC

CAAA

GGCAGCGUGUGGAG

CG

G G A G G A GAA

GAGGCCUCCG

GG

UG A

AG

GU A

AGU

AC

CUA

CA

CCAA

AA

ACU

GU

AGCC G

AA

AG

GG

CUUGCU

A

UCCUA

CCUU

UA

GACAGGUAGAAGAUUGUGGGAG

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GG

UC

GCU

CU

GC

G

GA

GA

GG

CU

GGCA

GAUUG

AG

CCC

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GUUCUCUCCAGCA

CU

AG

CA

GGU

AGA

GCC

UGGG

U GU

UC

CC

UG

CU

AG A

CU

CU

CACCAGCACU

UGGC

C G G U G C U G GG

CA

GA

CG

GC

CCCACGCUUGCUUGCUUAAA

AACC

UCUUAA

UAAA

G C U G CCAG U U

A GA A G C A A G UUA A G U G U G

UGC U C C C A U C U C U C C UAG U C

GC

C GCCUGGUCAUUCGGUGUUCACCUGAGUAACAAG

ACCCUG

GUC

U

GUUAGGA

CC

C UUCUUGCUUUGG

GA A

ACCGAGGCAGGAA A

AU

CCCUAGCA G

GUU

G GC

GC

C

UGAA

CAGGGA

CUUGA

AGA

AG

AC

UG A

GAA

GU

CU

U

GGAACACGG

CUGAGUGAAGGCA

GUAA G G G C

G G C A G GAACAAACCACGA C G G

AG U

G C U C CUA

G A AA

GG C G C G GG C C

G AG G

UAC

CAAA

GGCAGCGUGUGGAGCG

G G A G G A GAA

GAGGCCUCCG

GG

UG A

AG

GU A

AGU

AC

CUA

CA

CCA

AA

AACUGUA

GCC G

AA

AG

GG

CUUGCUAUCCU

ACCUUUAGACAGGUAGAAGAUUGUGGGAG

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GG

UC

GCU

CU

GC

G

GA

GA

GG

CU

GGCA

GAUUG

AG

CCC

UGGGA G

GUUCUCUCCAGCA

CU

AG

CA

GGU

AGA

GCC

UGGG

U GU

UC

CC

UG

CU

AG A

CU

CU

CA

CCAGCACUUG

GC

C G G U G C U G GG

CA

GA

CG

GC

CCCACGCUUGCUUGCUUAAA

AACC

UCUUAA

UAAA

G C U G CCAG U U

A GA A G C A A GUU A A G U G U G

UGC U C C C A U C U C U C C UAG U CGCCGCCU

G

GUCAUUCGGUGUUCACCUGAGUAACAAG

ACCCUG

GUC

U

GUUAGGA

CC

C UUCUUGCUUUGG

GA A

ACCGAGGCAGGAA A

AU

CCCUAGCA G

GUU

G GC

GC

C

UGAA

CAGGGA

CUUGA

AGA

AG

AC

UG A

GAA

GU

CU

U

GGAACACGG

CUGAGUGAAG

GCAG

UAAG

GGCGGCAG

G AACAAAC C A C

GAC

G G AG U

GCUCCU A G AAAGG

C G CGGG C C

G AG G

UAC

CAAA

GGCAGCGUGUGGAG

CG

G G A G G A GAA

GAGGCCUCCG

GG

UG A

AG

GU A

AGU

AC

CUA

CA

CCAA

AA

ACU

GU

AGCC G

AA

AG

GG

CUUGCU

A

UCCUA

CCUU

UA

GACAGGUAGAAGAUUGUGGGAG

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GG

UC

GCU

CU

GC

G

GA

GA

GG

CU

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AG

CCC

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GUUCUCUCCAGCA

CU

AG

CA

GGU

AGA

GCC

UGGG

U GU

UC

CC

UG

CU

AG A

CU

CU

CACCAGCACU

UGGC

C G G U G C U G GG

CA

GA

CG

GC

CCCACGCUUGCUUGCUUAAA

AACC

UCUUAA

UAAA

G C U G CCAG U U

A GA A G C A A G UUA A G U G U G

UGC U C C C A U C U C U C C UAG U C

GC

C GCCUGGUCAUUCGGUGUUCACCUGAGUAACAAG

ACCCUG

GUC

U

GUUAGGA

CC

C UUCUUGCUUUGG

GA A

ACCGAGGCAGGAA A

AU

CCCUAGCA G

GUU

G GC

GC

C

UGAA

CAGGGA

CUUGA

AGA

AG

AC

UG A

GAA

GU

CU

U

GGAACACGG

CUGAGUGAAGGCA

GUAA G G G C

G G C A G GAACAAACCACGA C G G

AG U

G C U C CUA

G A AA

GG C G C G GG C C

G AG G

UAC

CAAA

GGCAGCGUGUGGAGCG

G G A G G A GAA

GAGGCCUCCG

GG

UG A

AG

GU A

AGU

AC

CUA

CA

CCA

AA

AACUGUA

GCC G

AA

AG

GG

CUUGCUAUCCU

ACCUUUAGACAGGUAGAAGAUUGUGGGAG

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GG

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CU

GC

G

GA

GA

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CU

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AG

CCC

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GUUCUCUCCAGCA

CU

AG

CA

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AGA

GCC

UGGG

U GU

UC

CC

UG

CU

AG A

CU

CU

CACCAGCACU

UGGC

C G G U G C U G GG

CA

GA

CG

GC

CCCACGCUUGCUUGCUUAAA

AACC

UCUUAA

UAAA

G C U G CCAG U U

A GA A G C A A G UUA A G U G U G

UGC U C C C A U C U C U C C UAG U C

GC

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ACCCUG

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U

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CC

C UUCUUGCUUUGG

GA A

ACCGAGGCAGGAA A

AU

CCCUAGCA G

GUU

G GC

GC

C

UGAA

CAGGGA

CUUGA

AGA

AG

AC

UG A

GAA

GU

CU

U

GGAACACGG

CUGAGUGAAGGCA

GUAA G G G C

G G C A G GAACAAACCACGA C G G

AG U

G C U C CUA

G A AA

GG C G C G GG C C

G AG G

UAC

CAAA

GGCAGCGUGUGGAGCG

G G A G G A GAA

GAGGCCUCCG

GG

UG A

AG

GU A

AGU

AC

CUA

CA

CCA

AA

AACUGUA

GCC G

AA

AG

GG

CUUGCUAUCCU

ACCUUUAGACAGGUAGAAGAUUGUGGGAG

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GG

UC

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GC

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GG

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CCC

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CU

AG

CA

GGU

AGA

GCC

UGGG

U GU

UC

CC

UG

CU

AG A

CU

CU

CA

CCAGCACUUG

GC

C G G U G C U G GG

CA

GA

CG

GC

CCCACGCUUGCUUGCUUAAA

AACC

UCUUAA

UAAA

G C U G CCAG U U

A GA A G C A A GUU A A G U G U G

UGC U C C C A U C U C U C C UAG U CGCCGCCU

G

GUCAUUCGGUGUUCACCUGAGUAACAAG

ACCCUG

GUC

U

GUUAGGA

CC

C UUCUUGCUUUGG

GA A

ACCGAGGCAGGAA A

AU

CCCUAGCA G

GUU

G GC

GC

C

UGAA

CAGGGA

CUUGA

AGA

AG

AC

UG A

GAA

GU

CU

U

GGAACACGG

CUGAGUGAAG

GCAG

UAAG

GGCGGCAG

G AACAAAC C A C

GAC

G G AG U

GCUCCU A G AAAGG

C G CGGG C C

G AG G

UAC

CAAA

GGCAGCGUGUGGAG

CG

G G A G G A GAA

GAGGCCUCCG

GG

UG A

AG

GU A

AGU

AC

CUA

CA

CCAA

AA

ACU

GU

AGCC G

AA

AG

GG

CUUGCU

A

UCCUA

CCUU

UA

GACAGGUAGAAGAUUGUGGGAG

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[kca

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EB distance to structure 1 [kcal/mol]

Validation of clustering results of HIV2 leader

_J`>a b djf����� � ����������� � 0

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