CANCERVOL. 88, NO.1; 1 JANUARY, 2000

EDITORIALCANCER launches Accelerated Publication: a message from the Editor –in - ChiefRobert V. P. Hutter

1

COMMENTARYThe new millennium: Applying novel technology to the study of thecancer cell in situMonica R. Brown, Elise C. Kohn, Robert V. P. Hutter

2-5

REVIEW ARTICLEOral bisphosphonates: A review of clinical use in patients with bonemetastasesPierre P. Major, Allan Lipton, James Berenson, Gabriel Hortobagyi

6-14

ORIGINAL ARTICLEANATOMIC SITESALIVARY GLAND ( C08.9)Kaposi sarcoma of major salivary gland origin: A clinicopathologic seriesof six casesJames T. Castle, Lester D. R. Thompson

15-23

STOMACH (C16.9)Fhit expression in gastric adenocarcinoma: Correlation with disease stageand survivalDavid Capuzzi, Emanuele Santoro, Walter W. Hauck, Albert J. Kovatich,Francis E. Rosato, Raffaele Baffa, Kay Huebner, Peter A. McCue

24-34

COLON AND RECTUM (C19.9)Time-dependency of the prognostic effect of carcinoembryonic antigenand p53 protein in colorectal adenocarcinomaManuel Díez, Marina Pollán, Jose M. Müguerza, Maria J. Gaspar, AntonioM. Duce, María J. Alvarez, Tomás Ratia, Pilar Hernández, Antonio Ruiz,Javier Granell

35-41

Expression of platelet-derived endothelial cell growth factor correlateswith good prognosis in patients with colorectal carcinomaShinsuke Saito, Nelson Tsuno, Hirokazu Nagawa, Eiji Sunami, JinZhengxi, Takuya Osada, Joji Kitayama, Yoichi Shibata, Takashi Tsuruo,Tetsuichiro Muto

42-49

LIVER (C22.0)A prognostic index of the survival of patients with unresectablehepatocellular carcinoma after transcatheter arterial chemoembolizationLaura Lladó, Joan Virgili, Joan Figueras, Carles Valls, Joan Dominguez,Antoni Rafecas, Jaume Torras, Joan Fabregat, Jordi Guardiola, EduardoJaurrieta

50-57

The effect of retreatment with interferon- α on the incidence ofhepatocellular carcinoma in patients with chronic hepatitis CHidenori Toyoda, Takashi Kumada, Satoshi Nakano, Isao Takeda, KeiichiSugiyama, Seiki Kiriyama, Yasuhiro Sone, Yasuhiro Hisanaga

58-65

GASTROINTESTINAL TRACT (C26.9)Salvage surgery for patients with recurrent gastrointestinal sarcoma:Prognostic factors to guide patient selectionSatvinder S. Mudan, Kevin C. Conlon, James M. Woodruff, Jonathan J.Lewis, Murray F. Brennan

66-74

BLOOD/BONE MARROW (C42.1)Increased CA 125 serum levels in patients with advanced acute leukemiawith serosal involvementAndrea Camera, Maria Rosaria Villa, Stefano Rocco, Tiziana De Novellis,Silvia Costantini, Luca Pezzullo, Anna Lucania, Angela Mariano,Vincenzo Macchia, Bruno Rotoli

75-78

SKIN (C44.9)Paclitaxel and tamoxifen: An active regimen for patients with metastaticmelanomaFaith E. Nathan, David Berd, Takami Sato, Michael J. Mastrangelo

79-87

Locally advanced melanoma: Results of postoperative hypofractionatedradiation therapyGraham Stevens, John F. Thompson, Ian Firth, Christopher J. O'Brien,William H. McCarthy, Michael J. Quinn

88-94

BREAST (C50.9)Outcome of patients with metastatic breast carcinoma treated at a privatemedical oncology clinicWilliam F. Anderson, James E. Reeves, Abdalla Elias, Hans (J) Berkel

95-107

A high number of tumor free axillary lymph nodes from patients withlymph node negative breast carcinoma is associated with poor outcomeRobert L. Camp, Eric B. Rimm, David L. Rimm

108-113

Racial differences in breast carcinoma survivalSue A. Joslyn, Michele M. West

114-123

A Phase II study of paclitaxel plus carboplatin as first-line chemotherapyfor women with metastatic breast carcinomaEdith A. Perez, David W. Hillman, Philip J. Stella, James E. Krook, LynnC. Hartmann, Tom R. Fitch, Alan K. Hatfield, James A. Mailliard, SureshNair, Carl G. Kardinal, James N. Ingle

124-131

CERVIX (53.9)Bax and Bcl-2 protein expression following radiation therapy versusradiation plus thermoradiotherapy in Stage IIIB cervical carcinomaYoko Harima, Kenji Nagata, Keizo Harima, Atsutoshi Oka, Valentina V.Ostapenko, Nobuaki Shikata, Takeo Ohnishi, Yoshimasa Tanaka

132-138

ENDOMETRIUM (C.54.1)Does hysteroscopy facilitate tumor cell dissemination?: Incidence ofperitoneal cytology from patients with early stage endometrial carcinomafollowing dilatation and curettage (D & C) versus hysteroscopy and D & CAndreas Obermair, Magda Geramou, Fatih Gucer, Ursula Denison, AntonH. Graf, Elisabeth Kapshammer, Walter Neunteufel, Inge Frech,Alexandra Kaider, Christian Kainz

139-143

OVARY (56.9)The role of secondary cytoreductive surgery in the treatment of patientswith recurrent epithelial ovarian carcinomaScott M. Eisenkop, Richard L. Friedman, Nick M. Spirtos

144-153

TESTIS (C62.9)Testicular lymphoma is associated with a high incidence of extranodalrecurrenceRafael Fonseca, Thomas M. Habermann, Joseph P. Colgan, Brian P.O'Neill, William L. White, Thomas E. Witzig, Kathleen S. Egan, James A.Martenson, Lawrence J. Burgart, David J. Inwards

154-161

Tumor markers at the time of recurrence in patients with germ cell tumorsJosé M. Trigo, José M. Tabernero, Luis Paz-Ares, José L. García-Llano,José Mora, Pilar Lianes, Emilio Esteban, Ramón Salazar, Juan J. López-López, Hernán Cortés-Funes

162-168

NERVOUS SYSTEM NOS (C72.9)Chemotherapy in patients with recurrent and progressive centralneurocytomaAlba A. Brandes, Pietro Amistà, Marina Gardiman, Lorenzo Volpin,Daniela Danieli, Bianca Guglielmi, Carla Carollo, Gianpietro Pinna,Sergio Turazzi, Silvio Monfardini

169-174

LYMPH NODE (C77.9)Lymph node metastases: The importance of the microenvironmentAlessandro D. Santin

175-179

GENERAL TOPICCHEMOTHERAPY: SOLID TUMOR METASTASESA Phase I study of gemcitabine and docetaxel in patients with metastaticsolid tumorsDavid P. Ryan, Thomas J. Lynch, Michael L. Grossbard, Michael V.Seiden, Charles S. Fuchs, Nina Grenon, Paul Baccala, Deborah Berg,Dianne Finkelstein, Robert J. Mayer, Jeffrey W. Clark

180-185

PEDIATRIC ONCOLOGYLarge cell non-Hodgkin lymphoma of childhood: Analysis of 78consecutive patients enrolled in 2 consecutive protocols at the MemorialSloan-Kettering Cancer CenterJaume Mora, Daniel A. Filippa, Howard T. Thaler, Tatyana Polyak,Milicent L. Cranor, Norma Wollner

186-197

Hemangiopericytoma in children and infantsCarlos Rodriguez-Galindo, Kirk Ramsey, Jesse J. Jenkins, Catherine A.Poquette, Sue C. Kaste, Thomas E. Merchant, Bhaskar N. Rao, Charles B.Pratt, Alberto S. Pappo

198-204

Effective preventive central nervous system therapy with extended tripleintrathecal therapy and the modified ALL-BFM 86 chemotherapy programin an enlarged non-high risk group of children and adolescents with non-B-cell acute lymphoblastic leukemia: The Israel National Study reportBatia Stark, Rivka Sharon, Gideon Rechavi, Dina Attias, Ami Ballin,Gabriel Cividalli, Yoav Burstein, Dalia Sthoeger, Ayala Abramov, Rina

205-216

ZaizovQUALITY OF LIFEEvaluation of an instrument to assess the needs of patients with cancerBillie Bonevski, Rob Sanson-Fisher, Afaf Girgis, Louise Burton, PeterCook, Allison Boyes

217-225

The unmet supportive care needs of patients with cancerRob Sanson-Fisher, Afaf Girgis, Allison Boyes, Billie Bonevski, LouiseBurton, Peter Cook

226-237

CORRESPONDENCEThe prognostic significance of amplification and overexpression of c-metand c-erb B-2 in human gastric carcinomasFátima Carneiro, Manuel Sobrinho-Simões

238-239

Author replyMasakazu Nakajima

239-240

Extramedullary plasmacytoma: Tumor occurrence and therapeuticconceptsNilüfer Güler

240-241

Author replyChristoph Alexiou, Wolfgang Arnold

241-242

Pathologic findings from the national surgical adjuvant breast project(NSABP) eight-year update of protocol B-17Melvin J. Silverstein, Michael D. Lagios

242-243

Author replyEdwin R. Fisher

243-244

VOL. 88, NO. 2; 15 JANUARY 2000ORIGINAL ARTICLEANATOMIC SITEORAL CAVITY (C06.9)Immunohistochemical study of MUC1 mucin in premalignant oral lesionsand oral squamous cell carcinoma: Association with disease progression,mode of invasion, and lymph node metastasisTetsuya Nitta, Kazumasa Sugihara, Shinichro Tsuyama, Fusayoshi Murata

245-254

NASOPHARYNX ( C11.9)Elevation of serum vascular endothelial growth factor in male patientswith metastatic nasopharyngeal carcinomaChao-Nan Qian, Chang-Qing Zhang, Xiang Guo, Ming-Huang Hong, Su-Mei Cao,Wei-Yuan Mai, Hua-Qing Min, Yi-Xin Zeng

255-261

ESOPHAGUS (C15.9)Small cell carcinoma of the esophagus: The University of Texas M. D.Anderson Cancer Center Experience and Literature ReviewDiana C. Medgyesy, Robert A. Wolff, Joe B. Putnam Jr., Jaffer A. Ajani

262-267

Gains of 8q23-qter and 20q and loss of 11q22-qter in esophagealsquamous cell carcinoma associated with lymph node metastasisKohsuke Tada, Masaaki Oka, Akira Tangoku, Hiroto Hayashi, AtsunoriOga, Kohsuke Sasaki

268-273

STOMACH ( C16.9)Individual and joint contribution of family history and Helicobacter pyloriinfection to the risk of gastric carcinomaHermann Brenner, Volker Arndt, Til Stürmer, Christa Stegmaier, HartwigZiegler, Georg Dhom

274-279

Detection of circulating gastric carcinoma-associated antigen MG7-Ag inhuman sera using an established single determinant immuno-polymerasechain reaction techniqueJun Ren, Zheng Chen, Shao Juan Zhou, Xue Yong Zhang, Bo Rong Pan,Dai Ming Fan

280-285

SMALL INTESTINE (C17.9)A clinicopathologic study of primary small intestine lymphoma:Prognostic significance of mucosa-associated lymphoid tissue-derivedlymphomaShotaro Nakamura, Takayuki Matsumoto, Morishige Takeshita, KoichiKurahara, Takashi Yao, Masazumi Tsuneyoshi, Mitsuo Iida, MasatoshiFujishima

286-294

COLON AND RECTUM ( C19.9)Tissue factor expression in human colorectal carcinoma: Correlation withhepatic metastasis and impact on prognosisShin-ichi Seto, Hisashi Onodera, Toshimi Kaido, Akira Yoshikawa, Shun-ichi Ishigami, Shigeki Arii, Masayuki Imamura

295-301

LIVER (C22.0)Percutaneous microwave coagulation therapy for patients with primary andmetastatic hepatic tumors during interruption of hepatic blood flowTakashi Shibata, Takamichi Murakami, Norio Ogata

302-311

Precancerous hepatic nodules had significant levels of telomerase activitydetermined by sensitive quantitation using a hybridization protection assayHideki Takaishi, Mikiya Kitamoto, Shoichi Takahashi, Hiroshi Aikata,Yoshiiku Kawakami, Toshio Nakanishi, Yasuhiro Nakamura, FumioShimamoto, Goro Kajiyama, Toshinori Ide

312-317

LUNG (C34.9)UFT plus cisplatin combination chemotherapy in the treatment of patientswith advanced nonsmall cell lung carcinoma: A multiinstitutional Phase IItrialYukito Ichinose, Kozo Yosimori, Shuichi Yoneda, Mutsuo Kuba, ShojiKudoh, Hisanobu Niitani

318-323

BONE (C41.9)Osteosarcomas of flat bones in adolescents and adultsFlorence Duffaud, Laurence Digue, Marjorie Baciuchka-Palmaro,Françoise Volot, Catherine Perles-Daniel, Louise Garbe, Roger Favre

324-332

BLOOD/BONE MARROW (C42.1)Plasma FLT3-L levels predict bone marrow recovery frommyelosuppressive therapyRosalyn D. Blumenthal, Walter Lew, Malik Juweid, Rita Alisauskas,Zhiliang Ying, David M. Goldenberg

333-343

Derivation of a new hematopoietic cell line with endothelial features froma patient with transformed myeloproliferative syndrome: A case reportWalter Fiedler, R. Peter Henke, Süleyman Ergün, Udo Schumacher,Ursula M. Gehling, Gabi Vohwinkel, Nerbil Kilic, Dieter K. Hossfeld

344-351

Deoxycoformycin in the treatment of patients with hairy cell leukemia:Results of a Spanish collaborative study of 80 patientsMontserrat Rafel, Francisco Cervantes, José María Beltrán, FranciscoZuazu, Luis Hernández Nieto, Consuelo Rayón, Juan García Talavera,Emilio Montserrat

352-357

PERITONEUM (C48.2)Peritoneal carcinomatosis from non-gynecologic malignancies: Results ofthe EVOCAPE 1 multicentric prospective studyBabak Sadeghi, Catherine Arvieux, Olivier Glehen, Annie C. Beaujard,Michel Rivoire, Jacques Baulieux, Eric Fontaumard, Alain Brachet, JeanL. Caillot, Jean L. Faure, Jack Porcheron, Jean L. Peix, Yves François,Jacques Vignal, François N. Gilly

358-363

SOFT TISSUE (C49.9)Metastases to the retroperitoneum in patients with extremity soft tissuesarcoma: An unusual metastatic patternDina Lev-Chelouche, Richard Nakache, Dror Soffer, Ofer Merimsky,Joseph M.Klausner, Mordechai Gutman

364-368

BREAST (C50.9)Age-related variation in the treatment and outcomes of patients with breastcarcinomaJonathan Golledge, Joan E. Wiggins, Michael J. Callam

369-374

A phase II trial of high dose epirubicin in patients with advanced breastcarcinomaKathy D. Miller, Nikhil Munshi, David Loesch, Lawrence H. Einhorn,George W. Sledge Jr.

375-380

OVARY (C56.9)Antitumor activity of a novel glyco-nitric oxide conjugate in ovariancarcinomaGuilherme Cantuaria, Albino Magalhaes, Roberto Angioli, Luis Mendez,Ramin Mirhashemi, Jianqiang Wang, Peng Wang, Manuel Penalver,Hervy Averette, Paul Braunschweiger

381-388

Primary cytoreductive surgery with rectosigmoid colon resection forpatients with advanced epithelial ovarian carcinomaCarlo Scarabelli, Angelo Gallo, Silvia Franceschi, Elio Campagnutta,Giovanni De Piero, Giorgio Giorda, Maria Caterina Visentin, AntoninoCarbone

389-397

PROSTATE (C61.9)Second malignancies in prostate carcinoma patients after radiotherapycompared with surgeryDavid J. Brenner, Rochelle E. Curtis, Eric J. Hall, Elaine Ron

398-406

Short term neoadjuvant androgen deprivation therapy does not affectprostate specific membrane antigen expression in prostate tissues

407-415

Sam S. Chang, Victor E. Reuter, W. D. W. Heston, Brian Hutchinson,Lana S. Grauer, Paul B. GaudinPrognostic significance of p16 and CDK4 proteins in localized prostatecarcinomaOle J. Halvorsen, Jens Høstmark, Svein Haukaas, Per Å. Høis æter, Lars A.Akslen

416-424

A comparison of external beam radiation therapy versus radicalprostatectomy for patients with low risk prostate carcinoma diagnosed,staged, and treated at a single institutionAlvaro A. Martinez, Jose A. Gonzalez, Andrew K. Chung, Larry L.Kestin, Mamtha Balasubramaniam, Ananias C. Diokno, Ellen L. Ziaja,Donald S. Brabbins, Frank A. Vicini

425-432

BRAIN (C71.9)Predominance of brain tumors in an extended Li-Fraumeni (SBLA)kindred, including a case of Sturge-Weber syndromeHenry T. Lynch, Rodney D. McComb, Neal K. Osborn, Paul A. Wolpert,Jane F. Lynch, Zbigniew K. Wszolek, David Sidransky, Robert E. Steg

433-439

A role for telomeric and centromeric instability in the progression ofchromosome aberrations in meningioma patientsJeffrey R. Sawyer, Muhammad Husain, Svetlana Pravdenkova, Ali Krisht,Ossama Al-Mefty

440-453

LYMPH NODE (C77.9)Short term treatment with Escheria coli recombinant human granulocyte-macrophage-colony stimulating factor prior to chemotherapy for HodgkindiseaseM. Aglietta, F. Montemurro, F. Fagioli, C. Volta, B. Botto, M. Cantonetti,V. Racanelli, L. Teofili, R. Ferrara, S. Amadori, G. L. Castoldi, F.Dammacco, A. Levis

454-460

GENERAL TOPICGYNECOLOGIC CANCERThe tumor-associated shift in immunoglobulin G1/G2 is expressed at themessenger RNA level of peripheral blood B lymphocytes in patients withgynecologic malignanciesPeter Felsner, Waltraud Steinschifter, Michaela Fischer, Robert Eferl,Lukas Kenner, Kurt Zatloukal, Manfred Lahousen, Peter M. Liebmann,Erwin Schauenstein, Konrad Schauenstein

461-467

IMMUNOLOGY/IMMUNOTHERAPYOrthotopic human lung carcinoma xenografts in BALB/c miceimmunosuppressed with anti-CD4 monoclonal antibodies and chronicalcohol consumptionJay D. Hunt, Everett G. Robert, Arthur W. Zieske, Abraham P. Bautista,Mirjana Bukara, Dinghua Lei, Judd E. Shellito, Steve Nelson, Jay K.Kolls, Nebojsa Skrepnik

468-479

PEDIATRIC ONCOLOGYSplenic rupture in children with hematologic malignanciesUma H. Athale, Sue C. Kaste, Sara M. Bodner, Raul C. Ribeiro

480-490

VOL. 88, NO. 3; 1 FEBRUARY 2000EDITORIALMythology and numerology in the sphere of melanomaA. Bernard Ackerman

491-496

Secondary leukemia: Twice is a coincidence?Wallace Akerley

497-499

REVIEW ARTICLEClassic Kaposi sarcoma: Epidemiology and risk factorsJose Iscovich, Paolo Boffetta, Silvia Franceschi, Esther Azizi, Ronit Sarid

500-517

ORIGINAL ARTICLEANATOMIC SITESALIVARY GLAND ( C08.9)H-ras gene mutations in salivary gland mucoepidermoid carcinomasJinyoung Yoo, Robert A. Robinson

518-523

ESOPHAGUS (C15.9)Fas ligand expression in esophageal carcinomas and their lymph nodemetastasesMamoun Younes, Mary R. Schwartz, Atilla Ertan, Delia Finnie, AnasYounes

524-528

LIVER (C22.0)Predictive factors for intrahepatic recurrence after percutaneous ethanolinjection therapy for small hepatocellular carcinomaMasahiko Koda, Yoshikazu Murawaki, Akeri Mitsuda, Kenji Ohyama,Yutaka Horie, Takeaki Suou, Hironaka Kawasaki, Shiro Ikawa

529-537

Is the pathologic TNM staging system for patients with hepatomapredictive of outcome?J. Wallis Marsh, Igor Dvorchik, C. Andrew Bonham, Shunzaburo Iwatsuki

538-543

Serum levels of des-γ-carboxy prothrombin measured using the revisedenzyme immunoassay kit with increased sensitivity in relation toclinicopathologic features of solitary hepatocellular carcinomaHiroaki Okuda, Toshimi Nakanishi, Kazuko Takatsu, Akiko Saito, NaoakiHayashi, Ken Takasaki, Kazuyuki Takenami, Masakazu Yamamoto,Masayuki Nakano

544-549

LUNG (C34.9)Differential retinoblastoma and p16INK4A protein expression inneuroendocrine tumors of the lungHirotoshi Dosaka-Akita, Philip T. Cagle, Hiromitsu Hiroumi, MasahiroFujita, Motoyuki Yamashita, Anupama Sharma, Yoshikazu Kawakami,William F. Benedict

550-556

Gemcitabine and vinorelbine in advanced nonsmall cell lung carcinoma: APhase II studyRogerio Lilenbaum, Roberto Cano, Michael Schwartz, Leonard Siegel,Jose Lutzky, Mark Lewis, Elisa Krill, Luis Barreras, Enrique Davila

557-562

Lung carcinoma in 36 patients with human immunodeficiency virusinfectionUmberto Tirelli, Michele Spina, Simonetta Sandri, Diego Serraino, Carlo

563-569

Gobitti, Marco Fasan, Alessandro Sinicco, Pierluigi Garavelli, Anna LisaRidolfo, Emanuela VaccherBLOOD/BONE MARROW (C42.1)Expression of thrombopoietin and its receptor (c-mpl) in chronicmyelogenous leukemia: Correlation with disease progression and responseto therapyKerim Kaban, Hagop Kantarjian, Moshe Talpaz, Susan O'Brien, JorgeCortes, Francis J. Giles, Sherry Pierce, Maher Albitar

570-576

STOMACH (C42.2)Prognostic value of intratumoral natural killer cells in gastric carcinomaSumiya Ishigami, Shoji Natsugoe, Koki Tokuda, Akihiro Nakajo,Xiangming Che, Hirohumi Iwashige, Kuniaki Aridome, Shuichi Hokita,Takashi Aikou

577-583

SKIN (C44.9)A clinical trial of intravenous vinorelbine tartrate plus tamoxifen in thetreatment of patients with advanced malignant melanomaLynn G. Feun, Niramol Savaraj, Judith Hurley, Angela Marini, ShenghanLai

584-588

Breslow thickness and Clark level in melanoma: Support for includinglevel in pathology reports and in American Joint Committee on CancerStagingAshfaq A. Marghoob, Karen Koenig, Flavia V. Bittencourt, Alfred W.Kopf, Robert S. Bart

589-595

BREAST (C50.9)Factors associated with local recurrence of mammographically detectedductal carcinoma in situ in patients given breast-conserving therapyLarry L. Kestin, Neal S. Goldstein, Mario D. Lacerna, MamthaBalasubramaniam, Alvaro A. Martinez, Murray Rebner, Jane Pettinga,Robert C. Frazier, Frank A. Vicini

596-607

Morbidity following sentinel lymph node biopsy versus axillary lymphnode dissection for patients with breast carcinomaPeter Schrenk, Roman Rieger, Andreas Shamiyeh, Wolfgang Wayand

608-614

PROSTATE (C61.9)Use of complementary health practices by prostate carcinoma patientsundergoing radiation therapyGary D. Kao, Pamela Devine

615-619

Acute myelogenous leukemia after exposure to strontium-89 for thetreatment of adenocarcinoma of the prostateSteven E. Kossman, Mark A. Weiss

620-624

URINARY BLADDER (C68.9)Flat intraepithelial lesions of the urinary bladderLiang Cheng, John C. Cheville, Roxann M. Neumann, David G. Bostwick

625-631

URINARY SYSTEM (C68.9)Inverted urothelial papilloma: Is ploidy, MIB-1 proliferative activity, orp53 protein accumulation predictive of urothelial carcinoma?John C. Cheville, Kevin Wu, Thomas J. Sebo, Liang Cheng, Darren

632-636

Riehle, Christine M. Lohse, V. Shane PankratzBRAIN (C71.9)Safety and efficacy of a multicenter study using intraarterial chemotherapyin conjunction with osmotic opening of the blood-brain barrier for thetreatment of patients with malignant brain tumorsNancy D. Doolittle, Michael E. Miner, Walter A. Hall, Tali Siegal, E.Jerome Hanson, Eva Osztie, Leslie D. McAllister, Joseph S. Bubalo, DaleF. Kraemer, David Fortin, Randal Nixon, Leslie L. Muldoon, Edward A.Neuwelt

637-647

HEAD AND NECK ( C76.0)Feasibility and early results of accelerated radiotherapy for head and neckcarcinoma in the elderlyAbdelkarim S. Allal, Daphné Maire, Minerva Becker, Pavel Dulguerov

648-652

GENERAL TOPICCANCER COMORBIDITYCancer and comorbidity: Redefining chronic diseasesKaren S. Ogle, G. Marie Swanson, Nancy Woods, Faouzi Azzouz

653-663

CANCER SCREENINGEarly findings from a community-based, cluster-randomized, controlledoral cancer screening trial in Kerala, IndiaRengaswamy Sankaranarayanan, Babu Mathew, Binu Jose Jacob, GigiThomas,Thara Somanathan, Paola Pisani, Manoj Pandey, KunnambathRamadas, K. Najeeb, Elizabeth Abraham

664-673

LIFE STYLE OF PATIENTS AFTER TREATMENT FOR CANCERCurrent health behaviors and readiness to pursue life-style changes amongmen and women diagnosed with early stage prostate and breast carcinomasWendy Demark-Wahnefried, Bercedis Peterson, Colleen McBride, IsaacLipkus, Elizabeth Clipp

674-684

PEDIATRIC ONCOLOGYRadiotherapy followed by high dose busulfan and thiotepa: A prospectiveassessment of high dose chemotherapy in children with diffuse pontinegliomasEric Bouffet, Marianne Raquin, Francois Doz, Jean-Claude Gentet,Chantal Rodary, Francois Demeocq, Pascal Chastagner, Patrick Lutz,Olivier Hartmann, Chantal Kalifa

685-692

Cerebral glucose metabolism in survivors of childhood acutelymphoblastic leukemiaMeri Kähkönen, Liisa Metsähonkala, Heikki Minn, Tapio Utriainen, TapioKorhonen, Marjá- Kaisu Norvasuo-Heilä-Saari,Tutula Äärima, HannaSuhanen-Polvi, Ulla Ruotsalaien, Olof Solin, and Toivo T. Salmi

693-700

QUALITY OF LIFEEvaluating the Quality of Cancer Care: Development of Cancer QualityIndicators for a Global Quality Assessment ToolJennifer L. Malin, Steven M. Asch , Eve A . Kerr, and Elizabeth A.McGlynn

701

CORRESPONDENCEHuman Immunodeficiency Virus Kaposi Sarcoma andLymphoproliferative Dosirders

708

VOL. 88, NO. 4; 15 FEBRUARY 2000REVIEW ARTICLEAdrenocortical carcinoma: Clinical and laboratory observationsBernardo Leo Wajchenberg, Maria A. Albergaria Pereira, Berenice B.Medonca, Ana C. Latronico, Paulo Campos Carneiro, Venancio A.Ferreira Alves, Maria Claudia N. Zerbini, Bernardo Liberman, GilbertoCarlos Gomes, Marvin A. Kirschner

711-736

ORIGINAL ARTICLEANATOMIC SITESTOMACH (C16.9)Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma:Results from a prospective study after 6.3 years of follow-upAnita A. M. Botterweck, Piet A. van den Brandt, R. Alexandra Goldbohm

737-748

SMALL INTESTINE (C17.9)Molecular identification of metastatic cancer to the skin using laser capturemicrodissection: A case reportSara Milchgrub, Ignacio I. Wistuba, Bong K. Kim, Cynthia Rutherford, JillUrban, Ponciano D. CruzJr., Adi F. Gazdar

749-754

COLON AND RECTUM (C19.9 )Adenomatous polyposis coli I1307K mutation in Jewish patients withdifferent ethnicity: Prevalence and phenotypeLiat Drucker, Ofer Shpilberg, Avivit Neumann, Jermey Shapira, RodicaStackievicz, Yoram Beyth, Shai Yarkoni

755-760

LIVER ( C22.0)Abnormal expression of hepatoma specific γ- glutamyl transferase andalteration of γ- glutamyl transferase gene methylation status in patientswith hepatocellular carcinomaDengfu Yao, Daorong Jiang, Zhongwei Huang, Jianxin Lu, Qiyuan Tao,Zhijian Yu, Xianyong Meng

761-769

GASTROINTESTINAL TRACT (C26.9)Treatment of carcinoid syndrome: A prospective crossover evaluation oflanreotide versus octreotide in terms of efficacy, patient acceptability, andtoleranceDermot O'Toole, Michel Ducreux, Gilles Bommelaer, Jean-LouisWemeau, Olivier Bouché, France Catus, Joëlle Blumberg, PhilippeRuszniewski

770-776

SOFT TISSUE (C49.9)Current follow-up strategies after potentially curative resection of 777-785

extremity sarcomas: Results of a survey of the members of the society ofsurgical oncologyAlan L. Beitler, Katherine S. Virgo, Frank E. Johnson, John F. Gibbs,William G. KraybillMenstrual and reproductive factors and risk of soft tissue sarcomasFrancesca Fioretti, Alessandra Tavani, Silvano Gallus, Eva Negri, SilviaFranceschi, Carlo LaVecchia

786-789

BREAST (C50.9)High dose chemotherapy and autologous blood stem cell support inwomen with breast carcinoma and isolated supraclavicular lymph nodemetastasesRick Abraham, Tracy Nagy, Paul E. Goss, Michael Crump

790-795

The predictive value of body protein for chemotherapy-induced toxicityAlireza Aslani, Ross C. Smith, Barry J. Allen, Nicholas Pavlakis, John A.Levi

796-803

The prognostic value of p53 and c-erb B-2 immunostaining is overratedfor patients with lymph node negative breast carcinoma: A multivariateanalysis of prognostic factors in 613 patients with a follow-up of 14-30yearsWenche Reed, Einar Hannisdal, Per Johannes Boehler, Stein Gundersen,Herman Host, Jahn Marthin Nesland

804-813

ENDOMETRIUM (C54.1)The frequency of p53, K-ras mutations, and microsatellite instabilitydiffers in uterine endometrioid and serous carcinoma: Evidence of distinctmolecular genetic pathwaysSigurd F. Lax, Brian Kendall, Hironori Tashiro, Robbert J. C. Slebos, LoraHedrick Ellenson

814-824

PROSTATE (C61.9)A randomized study comparing standard versus moderately high dosemegestrol acetate for patients with advanced prostate carcinoma: Cancerand leukemia Group B study 9181Nancy A. Dawson, Mark Conaway, Susan Halabi, Eric P. Winer, Eric J.Small, Diana Lake, Nicholas J. Vogelzang

825-834

KIDNEY (C64.9) 835-843Independent value of tumor size and DNA ploidy for the prediction ofdisease progression in patients with organ-confined renal cell carcinomaFranco Di Silverio, Paolo Casale, Dario Colella, Loreto Andrea, FulviaSeccareccia, Alessandro SciarraURINARY BLADDER (C67.9)Paraganglioma of the urinary bladder: Can biologic potential be predicted?Liang Cheng, Bradley C. Leibovich, John C. Cheville, Dharamdas M.Ramnani, Thomas J. Sebo, Roxann M. Neumann, Antonio G.Nascimento, Horst Zincke, David G. Bostwick

844-852

URINARY SYSTEM (C68.9)Atypical nephrogenic metaplasia of the urinary tract: A precursor lesion?Liang Cheng, John C. Cheville, Thomas J. Sebo, John N. Eble, David G.

853-861

BostwickBRAIN (C71.9)Evaluation of cell proliferation, epidermal growth factor receptor, and bcl-2 immunoexpression as prognostic factors for patients with World HealthOrganization Grade 2 oligodendrogliomaJorge S. Reis-Filho, Leonardo N. Faoro, Carla Carrilho, Luiz F. Bleggi-Torres, Fernando C. Schmitt

862-869

Stereotactic radiosurgery for recurrent ependymomaScott L. Stafford, Bruce E. Pollock, Robert L. Foote, Deborah A. Gorman,Diana F. Nelson, Paula J. Schomberg

870-875

HEAD AND NECK (C76.0)Mature results of a Phase III randomized trial comparing concurrentchemoradiotherapy with radiation therapy alone in patients with Stage IIIand IV squamous cell carcinoma of the head and neckDavid J. Adelstein, Pierre Lavertu, Jerrold P. Saxton, Michelle Secic,Benjamin G. Wood, John R. Wanamaker, Isaac Eliachar, Marshall Strome,Marjorie A. Larto

876-883

The origins of multiple squamous cell carcinomas in the aerodigestive tractMonique G. C. T. van Oijen, Fredriek G. J. Leppers vd Straat, Marcel G. J.Tilanus, Pieter J. Slootweg

884-893

LYMPH NODE (C77.9)Bone marrow staging of patients with non-Hodgkin lymphoma by flowcytometry: Correlation with morphologyPeter R. Duggan, David Easton, Joanne Luider, Iwona A. Auer

894-899

GENERAL TOPICPALLIATIVE CAREAssessment of the need for palliative care as perceived by individualcancer patients and their families: A review of instruments for improvingpatient participation in palliative careBart H. P. Osse, Myrra J. F. J. Vernooij-Dassen, Berna P. W. de Vree,Egbert Schadé, Richard P. T. M. Grol

900-911

COMMUNICATIONThe American College of Surgerons Commision on Cancer and theAmerican Cancer SocietyThe National Cancer Data Base report on treatment patterns forhepatocellular carcinomas: Improved survival of surgically resectedpatients, 1985-1996William G. Cance, Andrew K. Stewart, Herman R. Menck

912-920

The National Cancer Data Base report on poor survival of U.S. gastriccarcinoma patients treated with gastrectomy: Fifth edition American JointCommittee on Cancer staging, proximal disease, and the “differentdisease” hypothesisScott A. Hundahl, Jerri Linn Phillips, Herman R. Menck

921-932

National Cancer Data Base survey of breast cancer management forpatients from low income zip codesLaMar S. McGinnis, Herman R. Menck, Harmon J. Eyre, Kirby I. Bland,

933-945

Carol E. H. Scott-Conner, Monica Morrow, David P. WinchesterCONCENSUS CONFERENCE ON THE CLASSIFICATION OFDUCTAL CARCINOMA OF THE BREAST, APRIL 22-25, 1999Consensus Conference on the treatment of in situ ductal carcinoma of thebreast, April 22-25, 1999Gordon F. Schwartz, Lawrence J. Solin, Ivo A. Olivotto, Virginia L.Ernster, Peter I. Pressman

946-954

INTERNATIONAL UNION AGAINTS CANCER (UICC)Report on Prostate Cancer Tumor Marker Workshop 1999Alan W. Partin, Gerald P. Murphy, Michael K. Brawer

955-963

CORRESPONDENCEMultiple chondromatous hamartomas of the lung: A case report andreview of the literature with special reference to Carney syndromeuayib Yalçin, Aye Kars

964

Trilateral retinoblastoma: Is the location of the intracranial tumorimportant?Annette C. Moll, Saskia M. Imhof, Antoinette Y. N. Schouten-vanMeeteren, Maarten Boers

965-966

VOL. 88, NO: 5; 1 MARCH 2000TRIBUTEGerald P. Murphy, M.D., D.Sc.: In memoriamRobert V. P. Hutter

fmxx

EDITORIALDiscrepancies between east and westJeremy R. Jass

969-970

Pathologic analysis of sentinel lymph nodes in breast carcinomaLaura Liberman

971-977

EDITORIAL COUNTERPOINTDespite limited data, coexistent lobular carcinoma in situ should not be acontraindication to breast conservation for women with invasive breastcarcinomaHarry D. Bear, W. Hans Carter Jr., Margaret M. Grimes

978-981

REPLY TO COUNTERPOINTDespite limited data, coexistent lobular carcinoma in situ should not be acontraindication to breast conservation for women with invasive breastcarcinoma: ReplyAnthony L. Abner

982-983

ORIGINAL ARTICLEANATOMICSALIVARY GLAND (C08.9)Salivary flow and its relation with oral symptoms in terminally III patientsGavriel Chaushu, Michaela Bercovici, Shay Dori, Alexander Waller,Shlomo Taicher, Jona Kronenberg, Yoav P. Talmi

984-987

ESOPHAGUS (C15.9)A Phase I/II study of external beam radiation, brachytherapy, andconcurrent chemotherapy for patients with localized carcinoma of the

988-995

esophagus (Radiation Therapy Oncology Group study 9207): Final reportLaurie E. Gaspar, Kathryn Winter, Walter I. Kocha, Lawrence R. Coia,Arnold Herskovic, Mary GrahamDifferences in diagnostic criteria for esophageal squamous cell carcinomabetween Japanese and Western pathologistsRonald J. Schlemper, Sanford M. Dawsey, Masayuki Itabashi, AkinoriIwashita, Yo Kato, Morio Koike, Klaus J. Lewin, Robert H. Riddell,Tadakazu Shimoda, Pentti Sipponen, Manfred Stolte, Hidenobu Watanabe

996-1006

COLON AND RECTUM (C19.9)Preoperative treatment with tegafur suppositories enhances apoptosis andreduces the intratumoral microvessel density of human colorectalcarcinomaTakahiko Matsuura, Yasuhiko Fukuda, Tsuruo Fujitaka, TakashiNishisaka,Takashi Sakatani, Hisao Ito

1007-1015

LIVER (C22.0)Effect of viral status on recurrence after liver resection for patients withhepatitis B virus-related hepatocellular carcinomaShoji Kubo, Kazuhiro Hirohashi, Hiromu Tanaka, Tadashi Tsukamoto,Taichi Shuto, Takatsugu Yamamoto, Takashi Ikebe, Kenichi Wakasa,Shuhei Nishiguchi, Hiroaki Kinoshita

1016-1024

Lack of frameshift mutations at coding mononucleotide repeats inhepatocellular carcinoma in Japanese patientsAyuko Saeki, Shinji Tamura, Nobuyuki Ito, Shinichi Kiso, YasuoMatsuda, Iwao Yabuuchi, Sumio Kawata, Yuji Matsuzawa

1025-1029

p53 mutation pattern in hepatocellular carcinoma in workers exposed tovinyl chlorideMarkus Weihrauch, Gerhard Lehnert, Ferdinand Köckerling, ChristianWittekind, Andrea Tannapfel

1030-1036

PANCREAS (C25.9)Molecular detection of metastatic pancreatic carcinoma cells using amultimarker reverse transcriptase-polymerase chain reaction assayAnton Bilchik, Miki Miyashiro, Mark Kelley, Christine Kuo, YoshiyukiFujiwara, Shogi Nakamori, Morito Monden, Dave S. B. Hoon

1037-1044

LUNG (C34.9)Phase I trial of docetaxel and vinorelbine in patients with advancednonsmall cell lung carcinomaVincent A. Miller, Kenneth K. Ng, Lee M. Krug, Wendy Perez, BarbaraPizzo, Robert T. Heelan, Mark G. Kris

1045-1050

MEDIASTINUM (C38.3)Results of modern therapy for patients with mediastinal nonseminomatousgerm cell tumorsKristen N. Ganjoo, Karen M. Rieger, Kenneth A. Kesler, Matt Sharma,Douglas K. Heilman, Lawrence H. Einhorn

1051-1056

BLOOD/BONE MARROW (C42.1)ATM gene deletion in patients with adult acute lymphoblastic leukemiaMohammad A. Haidar, Hagop Kantarjian, Taghi Manshouri, Chin-Yung

1057-1062

Chang, Susan O'Brien, Emil Freireich, Michael Keating, Maher AlbitarSKIN (44.9)Analysis of prognosis and disease progression after local recurrence ofmelanomaXiang D. Dong, Douglas Tyler, Jeffrey L. Johnson, Pierre DeMatos,Hilliard F. Seigler

1063-1071

BREAST (C50.9)The relation between the presence and extent of lobular carcinoma in situand the risk of local recurrence for patients with infiltrating carcinoma ofthe breast treated with conservative surgery and radiation therapyAnthony L. Abner, James L. Connolly, Abram Recht, Bruce Bornstein,Asa Nixon, Stella Hetelekidis, Barbara Silver, Jay R. Harris, Stuart J.Schnitt

1072-1077

Cutaneous fibrosis induced by docetaxel: A case reportMark G. Cleveland, B. S. Ajaikumar, Rohini Reganti

1078-1081

Pamidronate prevents skeletal complications and is effective palliativetreatment in women with breast carcinoma and osteolytic bone metastases:Long term follow-up of two randomized, placebo-controlled trialsAllan Lipton, Richard L. Theriault, Gabriel N. Hortobagyi, JosephSimeone, Robert D. Knight, Kathleen Mellars, Dirk J. Reitsma, MaikaHeffernan, John J. Seaman

1082-1090

Mutant p53 protein overexpression in women with ipsilateral breast tumorrecurrence following lumpectomy and radiation therapyBruce C. Turner, Andrew A. Gumbs, Christopher J. Carbone, DarrylCarter, Peter M. Glazer, Bruce G. Haffty

1091-1098

Pathologic analysis of sentinel and nonsentinel lymph nodes in breastcarcinoma: A multicenter studyDonald L. Weaver, David N. Krag, Takamaru Ashikaga, Seth P. Harlow,Maureen O'Connell

1099-1107

CERVIX (C53.9)Expression of MN/CA9 Protein in Papanicolaou Smears ContainingAtypical Glandular Cells of Undetermined Significance Is a DiagnosticBiomarker of Cervical Dysplasia and NeoplasiaShu-Yuan Liao and Eric J. Stanbridge

1108

PROSTATE (C61.9)Primary Treatment Choices for Men with Clinically Localized ProstateCarcinoma Detected by ScreeningYan Yan, Gustavo F Carvalhal, William J. Catalona, and James D. Young

1122

BLADDER (C67.9)Expression of Thymidine Phosphorylase as an Indicator of Poor Prognosisfor Patients with Transitional Cell Carcinoma of the BladderJun-ichirou Aiima, Yoshiharu Imazono, Yuji Takebayashi, KenryuNishiyama, Tsutomu Shirahama, Suminori Akiba, Tatsuhiko Furukawa,Shin-ichi Akiyama, and Yoshitada Ohi

1131

THYROID (C73.9)Medullary Thyroid Carcinoma: Clinical Characteristics, Treatment, 1139

Prognostic Factors, and a Comparison of Staging SystemsElectron Kebebew, Philip H. G. Ituarte, Allan E. Siperstein, Quan-YangDuh, and Orlo H. ClarkPrimary Thyroid Teratomas: A Clinicopathologic Study of 30 CasesLester D. R. Thompson, Juan Rosai, and Clara S. Heffess

1149

ADRENAL GLAND (C74.9)Phase II Evaluation of Cisplatin and Etoposide Followed by Mitotane atDisease Progression in Patients with Locally Advanced or MetastaticAdrenocortical Carcinoma: A Southwest Oncology Group StudyStephen K. Williamson, Danika Lew, Gary J. Miller, Stanley P. Balcerzak,Laurence H. Baker, and E. David Crawford

1159

GENERAL TOPICPEDIATRIC ONCOLOGYAlternating Drug Pairs with or without Periodic Reinduction in Childrenwith Acute Lymphoblastic Leukemia in Second Bone Marrow Remission:A Pediatric Oncology Group StudyGeorge R. Buchanan, Gaston K. Rivera, Brad H. Pollock, James M.Boyett, Allen R. Chauvenet, Hans Wagner, David A. Maybee, William M.Crist, and Donald Pinkel

1166

Symptom and Quality of Life Survey of Medical Oncology Patients at aVeterans Affairs Medical Center: A Role for Symptom AssessmentVictor T. Chang, Shirley S. Hwang, Martin Feuerman, and Basil S.Kasimis

1175

CORRESPONDENCEPretreatment Staging by Endoscopic Ultrasonography Does Not PredictComplete Response to Neoadjuvant Chemoradiation in Patients withEsophageal Carcinoma

1184

VOL. 88, SUPLEMENTO 5; 1 MARCH 2000Acknowledgments,Workshop Plannig Committe Roster, Etiology WorkingGroup Roster, and Workshop Participants

vii

Introduction to the workshopDoris Browne, A. Patricia Romilly-Harper

1187-1188

KEYNOTE ADDRESSA conceptual framework for the planning of ethno-oncologyM. Alfred Haynes

1189-1192

WORKGROUP PRESENTATIONSEpidemiology, stage at diagnosis, and tumor biology of breast carcinomain multiracial and multiethnic populationsCarrie P. Hunter

1193-1202

Migration patterns and breast carcinomaJudith Salmon Kaur

1203-1206

Urban Native American health issuesLinda Burhansstipanov

1207-1213

Changing the research paradigm: Community involvement in population-based researchNgina Lythcott

1214-1216

The excess burden of breast carcinoma in minority and medicallyunderserved communities: Application, research, and redressinginstitutional racismSusan M. Shinagawa

1217-1223

Ongoing research to identify environmental risk factors in breastcarcinomaMarian C. Johnson-Thompson, Janet Guthrie

1224-1229

Breast carcinoma etiology: Current knowledge and new insights into theeffects of reproductive and hormonal risk factors in black and whitepopulationsDorothy R. Pathak, Janet R. Osuch, Jianping He

1230-1238

Diet and breast carcinoma in multiethnic populationsAnna H. Wu

1239-1244

Dietary and/or nutritional risk factors and breast carcinoma: ConsumerresponseJackie Young

1245-1247

Associations between energy balance and body mass index and risk ofbreast carcinoma in women from diverse racial and ethnic backgrounds inthe U.S.Anne McTiernan

1248-1255

Socioeconomic factors and breast carcinoma in multicultural womenClaudia R. Baquet, Patricia Commiskey

1256-1264

Multicultural aspects of breast cancer etiology workshop: ConcludingcommentsJames N. Ingle

1265-1266

Abstracts of poster presentations 1267-1271Recommendations of the workshopDoris Browne, A. PatriciaRomilly-Harper

1272-1276

VOL. 88, NO. 7; 1 APRIL 2000EDITORIAL COUNTERPOINTWorld Health Organization and International Society of UrologicalPathology classification and two-number grading system of bladder tumorsRyoichi Oyasu

1509-1512

REPLY TO COUNTERPOINTWorld Health Organization and International Society of UrologicalPathology Classification and two-number grading system of bladdertumors: replyLiang Cheng, David G. Bostwick

1513-1516

REVIEW ARTICLESurgery versus radiation therapy for patients with aggressive fibromatosisor desmoid tumors: A comparative review of 22 articlesJoost J. Nuyttens, Philip F. Rust, Charles R. Thomas Jr., Andrew T. TurrisiIII

1517-1523

ORIGINAL ARTICLEANATOMIC SITEESOPHAGUS (C15.9)

Telomerase activity as an indicator of malignant potential in iodine-nonreactive lesions of the esophagusKazuo , Koyanagi , Soji Ozawa, Nobutoshi Ando, Makio Mukai, YukoKitagawa, Masakazu Ueda, Masaki Kitajima

1524-1529

STOMACH (C16.9)Assessment of gastric carcinoma risk associated with Helicobacter pylorimay vary depending on the antigen used: CagA specific enzyme-linkedimmunoadsorbent assay (ELISA) versus commercially available H. pyloriELISAsShin Maeda, Haruhiko Yoshida, Keiji Ogura, Yutaka Yamaji, TsuneoIkenoue, Toru Mitsushima, Hitoshi Tagawa, Ryuji Kawaguchi, KiyoshiMori, Ken-ichi Mafune, Takao Kawabe, Yasushi Shiratori, Masao Omata

1530-1535

COLON AND RECTUM (C19.9)Thomsen-Friedenreich antigen presents as a prognostic factor in colorectalcarcinoma: A clinicopathologic study of 264 patientsStephan E. Baldus, Thomas K. Zirbes, Franz-Georg Hanisch, DoreenKunze, Sven T. Shafizadeh, Silke Nolden, Stefan P. Mönig, Paul M.Schneider, Uwe Karsten, Juergen Thiele, Arnulf H. Hölscher, Hans P.Dienes

1536-1543

Prognostic influence of tumor-associated eosinophilic infiltrate incolorectal carcinomaM. J. Fernández-Aceñero, M. Galindo-Gallego, J. Sanz, A. Aljama

1544-1548

Limited but definite efficacy of prophylactic hepatic arterial infusionchemotherapy after curative resection of colorectal liver metastases: Arandomized studyTakeshi Tono, Yasunori Hasuike, Hiroki Ohzato, Yuichi Takatsuka,Nobuteru Kikkawa

1549-1556

LIVER (C22.0)Unique clinical characteristics of patients with hepatocellular carcinomawho present with high plasma des-γ-carboxy prothrombin and low serum -α fetoproteinKeisuke Hamamura, Yasushi Shiratori, Shuichiro Shiina, MasatoshiImamura, Shuntaro Obi, Shinpei Sato, Haruhiko Yoshida, Masao Omata

1557-1564

p53 tumor suppressor gene mutations in hepatocellular carcinoma patientsin indiaSanjay Katiyar, Bipin C. Dash, Varsha Thakur, Raj C. Guptan, Shiv K.Sarin, Bhudev C. Das

1565-1573

Transcatheter arterial chemoembolization therapy using iodized oil forpatients with unresectable hepatocellular carcinoma: Evaluation of threekinds of regimens and analysis of prognostic factorsKazuto Ueno, Nobuaki Miyazono, Hiroki Inoue, Hirotoshi Nishida, IchiroKanetsuki, Masayuki Nakajo

1574-1581

PANCREAS (C25.9)Hepatoid carcinoma of the pancreasGladell P. Paner, Karen S. Thompson, Cesar V. Reyes

1582-1589

LUNG (C34.9)

Atypical bronchopulmonary carcinoids show a tendency toward increasedapoptotic and proliferative activityKatja L. J. Laitinen, Ylermi Soini, Jorma Mattila, Paavo Pääkkö

1590-1598

BLOOD/BONE MARROW (C42.1)Cerebrospinal fluid lactate dehydrogenase isoenzyme analysis for thediagnosis of central nervous system involvement in hematooncologicpatientsIzidore S. Lossos, Raphael Breuer, Orna Intrator, Alexander Lossos

1599-1604

SKIN (C44.9)Perineural spread of basal cell carcinomas treated with mohs micrographicsurgeryDésirée Ratner, Lori Lowe, Timothy M. Johnson, Darrell J. Fader

1605-1613

SOFT TISSUE (C49.9)Growth inhibitory effects of paclitaxel on human epithelioid sarcoma invitro: Heterogeneity of response and the multidrug resistance phenotypePetra Reinecke, Christiane Knopf, Michael Schmitz, Eva M. Schneider,Helmut E. Gabbert, Claus D. Gerharz

1614-1622

BREAST (C50.9)Clinical implication of altered expression of Mad1 protein in human breastcarcinomaSehwan Han, Kyeongmee Park, Hong-Yong Kim, Myung-Soo Lee, Hong-Joo Kim, Young-Duck Kim, Young Jin Yuh, Sung Rok Kim, Hyun SukSuh

1623-1632

Primary axillary radiotherapy as axillary treatment in breast-conservingtherapy for patients with breast carcinoma and clinically negative axillarylymph nodesFrank J. P. Hoebers, Jacques H. Borger, Augustinus A. M. Hart, JohannesL. Peterse, Emiel J. Th.Rutgers, Joos V. Lebesque

1633-1642

Outcomes and factors impacting local recurrence of ductal carcinoma insituElaine Y. Weng, Guy J. F. Juillard, Robert G. Parker, Helena R. Chang,Jeffrey A. Gornbein

1643-1649

CERVIX (53.9)Human tumor growth is inhibited by a vaccinia virus carrying the E2 geneof bovine papillomavirusViviana Valadez Graham, Gerd Sutter, Marco V. José, Alejandro García-Carranca, Volker Erfle, Norma Moreno Mendoza, Horacio Merchant,Ricardo Rosales

1650-1662

BLADDER (C67.9)Cancer heterogeneity and its biologic implications in the grading ofurothelial carcinomaLiang Cheng, Roxann M. Neumann, Ajay Nehra, Bruce E. Spotts, Amy L.Weaver, David G. Bostwick

1663-1670

URINARY SYSTEM (C68.9)Ifosfamide, paclitaxel, and cisplatin for patients with advanced transitionalcell carcinoma of the urothelial tract: Final report of a phase II trial

1671-1678

evaluating two dosing schedulesDean F. Bajorin, John A. McCaffrey, Paul M. Dodd, Susan Hilton, MadhuMazumdar, W. Kevin Kelly, Harry Herr, Howard I. Scher, EvelynIcasiano, Geralyn HigginsSquamous papilloma of the urinary tract is unrelated to condylomaacuminataLiang Cheng, Bradley C. Leibovich, John C. Cheville, Dharamdas M.Ramnani, Thomas J. Sebo, Ajay Nehra, Reza S. Malek, Horst Zincke,David G. Bostwick

1679-1686

GENERAL TOPICFOLLOW-UP OF PATIENTS TREATED FOR CANCERGrading of late effects in young adult survivors of childhood cancerfollowed in an ambulatory adult settingKevin C. Oeffinger, Debra A. Eshelman, Gail E. Tomlinson, George R.Buchanan, Barbara M. Foster

1687-1695

HIV-RELATED NON-HODGKIN LYMPHOMAPrognostic factors after non-Hodgkin lymphoma in patients infected withthe human immunodeficiency virus: Aquitaine cohort, France, 1986-1997Frantz Thiessard, Philippe Morlat, Catherine Marimoutou, Eric Labouyrie,Jean-Marie Ragnaud, Jean-Luc Pellegrin, Michel Dupon, François Dabis

1696-1702

METASTATIC MELANOMA: PHASE II CLINICAL TRIALA phase II study of “decrescendo” interleukin-2 plus interferon-α-2a inpatients with progressive metastatic melanoma after chemotherapyOmar Eton, Antonio C.Buzaid, Agop Y. Bedikian, Teresa M. Smith,Nicholas E. Papadopoulos, Julie A. Ellerhorst, Janelle L. Hibberts, SewaS. Legha, Robert S. Benjamin

1703-1709

PEDIATRIC ONCOLOGYFeasibility of oral ciprofloxacin for the outpatient management of febrileneutropenia in selected children with cancerVictor M.Aquino, Larry Herrera, Eric S. Sandler, George R. Buchanan

1710-1714

QUALITY OF LIFEMeasuring quality of life of chinese cancer patients: A validation of theChinese version of the Functional Assessment of Cancer Therapy-general(FACT-G) scaleClara L. M. Yu, Richard Fielding, Cecelia L. W. Chan, Vincent K. C. Tse,Peter H. K. Choi, W. H. Lau, Damon T. K. Choy, S. K. O, Anne W. M.Lee, Jonathan S. T. Sham

1715-1727

UPPER AERODIGESTIVE TRACTCancers of the upper aerodigestive tract in Ontario, Canada, and theUnited StatesDavid P. Skarsgard, Patti A. Groome, William J. Mackillop, Sam Zhou,Deanna Rothwell, Peter F. Dixon, Brian O'Sullivan, Steven F. Hall, Eric J.Holowaty

1728-1738

COMMUNICATIONAMERICAN JOINT COMMITTE ON CANCERAmerican Joint Committee on Cancer prognostic factors consensus 1739-1757

conference: Colorectal working groupCarolyn Compton, Cecilia M. Fenoglio-Preiser, Norman Pettigrew, L.Peter FieldingCORRESPONDENCEThe natural history of breast carcinoma: What have we learned fromscreening?Thomas J. Anderson, Freda E. Alexander, Patrick M. Forrest

1758-1759

Determining the site of the primary cancer in patients with skeletalmetastasis of unknown origin: A retrospective studyJean Francis Maillefert, Christian Tavernier, Jacques Tebib

1759-1760