PAN AMERICAN HEALTH ORGANIZATION FIRST MEETING

PAN AMERICAN HEALTHORGANIZATION

FIRST MEETING18-22 JUNE 1962

WASHINGTON, D.C.ADVISORY COMMITTEEON MEDICAL RESEARCH

INTERNATIONALOF THE NATIONAL

RESEARCH ACTIVITIESINSTITUTES OF HEALTH

USPHS

Ref: RES 1/105 JUNE 1962

PAN AMERICAN HEALTH ORGANIZATIONPan American Sanitary Bureau, Regional Office of the

WORLD HEALTH ORGANIZATION

WASHINGTON, D.C.

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INTERNATIONAL RESEARCH ACTIVITIES OF THE

NATIONAL INSTITUTES OF HEALTH, USPUS*

A. GENERAL BACKGROUND

Legislation

The Public Health Service has engaged in international research and

training activities under basic authority provided the Surgeon General by

P.L. 86-610.

The International Health Research Act of 1960 was enacted in July of

1960. This legislation provided for the first time an explicit expression

of the will of Congress in respect to the support of health research over-

seas, although it added little in the way of new authority. Two major

purposes of the legislation were cited:

1. To advance the status of the health sciences in the United States

and thereby the health of the American people through cooperative

endeavors with the other countries in health research, and research

training; and

2. To advance the international status of the health sciences through

cooperative enterprises in health research, research planning,

and research training.

Significantly, the responsibility for the achievement of these two

objectives was separated. The responsibility for achieving objective #1 --

advancing the status of the health sciences in the United States through

*Prepared for the first meeting of the PARO Advisory Committee on MedicalResearch, 18-22 June 1962, by the Chief, Office of International Research,National Institutes of Health, USPHS.

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overseas research activities was given to the Surgeon General and the

Secretary of Health Education and Welfare (HEW). The responsibility for

objective #2 - advancing the international status of the health sciences -

was given to the President. The law indicates that he may delegate this

authority to the Secretary of HEW who may then in turn delegate it to

the PHS.

This clear distinction between the role of the Secretary and the

Surgeon General and that of the President under this Act in terms of the

purposes to which support of health research overseas is to be directed

is most significant. It clearly reinforces the concept of National

Institutes of Health (NIH) objectives set forth below. The intent of

Congress to distinguish between action in support of national objectives

and action aimed at broader international objectives is clearly evident.

Phio0i~ephy

NIR is part of a larger community of agencies and organizations in-

volved in international health activities. We may support or conduct re-

search by delegation of authority from these agencies. We may participate

in the actual support of research and research training based on the sta-

tutory provisions of our own legislation. In either circumstance, our

role is primarily related to our scientific mission.

Although research support programs may influence or affect the conduct

of foreign policy, the NIH international research program is not designed

for this purpose. Thus, a clear distinction must be drawn between tech-

nical assistance (foreign aid) and support of research abroad for domestic

or national purposes.

The assesament of foreign research support by NIH must consider the

aggregate effects on science ecology within a given country, as well as the

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ecientific merit of all individual research proposals. The size, scope,

and duration of research commitments may innocently disturb seriously the

plans and aspirations of a foreign domestic research program. Therefore,

action to support research abroad should be taken only after careful con-

sideration of all circumstances involved.

The rapid growth of NIH support of research abroad through research

grants from a level of $100,000 in 1955 to $8.4 million in 1961, provides

sufficient justification for concern that in certain instances, NIB foreign

grants may affect significantly the overall development of health programs

abroad. The NIH contribution to research abroad should be provided in such

a way as to insure that it will be additive rather than a replacement for

existing local support. Since the nature, scope, and magnitude of the

U. S. effort in international health science have been incompletely

assessed and evaluated, it is particularly important that NIH define its

responsibilities within its specific statutory authorizations. Efforts to

broaden our mission at this time beyond this authority can lead to con-

fusion and possibly to interagency problems. Thus, NIH recognizes that

the primary responsibility for certain other international scientific and

health activities, such as the development of medical education, rests

elsewhere. However, only through a delegation of Presidential authority

as contained in the International Health Research Act of 1960 can NIH

fulfill its domestic mission and be more responsive to the needs of other

national and international health agencies.

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sciences in the United States as well as the country of the applicant.

Research which is relevant to a specific NIH program may be supported by

contract or by research agreement.

The Office of International Research is responsible for establishing

mechanisms adequate to assure that the general policies and specific cri-

teria governing the NIH international programs are applied effectively

and economically.

This mechanism should be adequate to assure that all research appli-

cations are reviewed, preferably on the scene, by a person or group having

the full confidence of NIH. Reviewera may include Study Section or Council

membera, U. S. scientists with personal knowledge of applicants and their

institutions, foreign scientists in whom NIH has confidence, or NIH staff

membera.

Preliminary review should take into account the ability of the scien-

tist, the worth of his proposal, the environment within which he works, and,

when appropriate, the total content of the nations's effort in the medical

aciences.

Cxriteria :fol F~eian Awards

The National Institutes of Health will accept for scientific evaluat-

ion and review research proposals which meet both of the following criteria:

1. The research proposed is outstanding, or original in concept,

or would utilize the talents, skilla, materials, or other resources

not likely to be available in the United States; and

2. The proposal is of such a nature that the results are likely

to advance significantly the status of the health sciences in

both the country of the applicant and the United States.

Mechanisms

Whenever possible, the existing mechanisms of receipt of applications

and the scientific and administrative review of research proposals will be

the responsibility of the Institutes and Divisions involved. However,

those international program areas which go beyond the responsibilities and

interests of a single Institute and which relate to NIH as a whole become

the responsibility of the Office of the Director, NIH. The existence of

activities and problems of this nature (in large measure resulting from the

need to inform and clear international research developments with many other

elements of PHS, Office of the Secretary, HEW, Department of State, etc.)

has led to the establishment of a coordinating office of international

research. In order to perform these functions as well as to facilitate

program analysis and budgetary planning, the following functions are per-

formed by the Office of International Research (OIR), Office of the Director,

NIH:

This office is responsible for coordinating all international activities

of the National Institutes of Health. It advises the Director and the

Office of the Surgeon General on matters relating to the international

aspects of medical research and research training, and asaists the

Institutes in development of international programs. It is specific-

ally responsible for administration of the NIH P.L. 480 program and

coordinating Institute proposals for research under this program in

foreign countries. The office constitutes the central point within

NIH for relationships with the World Health Organization, the Pan

American Health Organization, and other international research and

scientific organizations. The office is comprised of an Office of

the Chief, a Foreign Grants and Awards Section, a Special Foreign

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Currency and Program Services Section, and a Program Analysis Section,

The office is also responsible for establishing and administering NIH

overseas offices.

This office will provide a mechanism whereby the National Institutes

of Health can work with international organizations, foreign institutions,

and scientists on a planned, predictable long-range basis.

The OIR, in collaboration with the Institutes, will be responsible for

an organized systematic assessment of medical research potential and

research resources in foreign countries. This will facilitate the

implementation of direct (intramural) conduct of research overseas

by NIH as well as providing information for Study Sections and Advisory

Councils in their review of foreign grant applications.

B. ACTIVITIES IN FISCAL YEAR 1961

The fiscal year 1961 review of the status of the international activit-

ies of the National Institutes of Health indicates substantial progress and

growth have taken place. Two new programs of particular significance have

been launched in addition to the further development of programs continued

from the previoue year. These two programs are the International Centers

for Medical Research and Training and the Special Foreign Currency Program.

Altogether obligation for NIH activities outside the United States (exclu-

sive of the Foreign Currency Program) totaled $12.2 million in fiscal year

1961 in contrast-to a total of $7.1 million obligated for similar purposes

in fiscal year 1960.

In the departmental appropriation (F.Y. 1961), a sum of $5 million was

designated for the development of international activities under the

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Surgeon General's authorities provided by Public Law 86-610.

Approximately $2.4 million of this amount has been allocated for the

development of a series of International Centers for Medical Research and

Training in accordance with the direction given in the Senate discussion

of this particular amount. The remainder of this amount ($2.6 million)

was utilized by the several Institutes and the Division of General Medical

Sciences for the support of carefully planned and purposely developed

research projects involving foreign investigators and institutions and

directed toward research and research training objectives of key signifi-

cance to these programs,. A summary of the status of these activities follows.

1. Regular Research Grante and Contracts

Research Grants and Contracts for the support of foreign investigator

working on problems relevant to the general and categorical programs of

the NIH amounted to $5,008,016 for a total of 303 such awards in fiscal

year 1960. Comparable figures for foreign research grants and contracts

in fiscal year 1961 reveal 506 awards made totaling approximately $8.4

million (see Tables I and II).

At current levels of support, the NIH program constitutes one of the

largest U.S. federal agency programs of support for research in foreign

countries. It is expected that the volume of research support for foreign

investigators will continue to increase during fiscal year 1962.

The basic rationale underlying this growing expenditure for the support

of medical research in foreign countries is that there is specific reason

to believe that the work supported will significantly contribute to the

achievement of the program objectives of the National Institutes of Health.

Therse program objectives, in the first place, relate to progress in under-

standing and controlling major categorical diseases of national significance

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and, in the second place, to strengthening and advancing the medical and

health sciences generally. The objective of the National Institutes of

Health in providing grant support for research carried out by foreign

investigators and institutions is to secure the benefits to its program

objectives of the superior scientific capability or exceptional research

opportunities, which may be presented by such individuals or facilities

and their scientific endeavors. Reflecting the above rationale the cri-

teria followed by the National Institutes of Health in making awards to

foreign investigators and institutions, beyond the usual scientific

evaluation, are as follows:

(a) The research activities proposed must be significantly relevant

to the program objectives of the NIH, and

(b) The research material is geographically so located that it can

best be studied outside the United States, or

(c) The research facilities are of such nature or in such location

as not to be duplicated in the United States, and

(d) The training, competence or stature of the applicant is such as

to provide a high degree of assurance of productive results

from the work supported.

2. Training Support

During fiscal year 1960, a total of $2.1 million was expended by NIH

for research training activities on an international basis. Comparable

expenditures in fiscal year 1961 were $2.7 million. Plans for 1962 based

on present budgetary determinations contemplate only a modest increase in

these activities.

The NIH International Fellowships Program is a major element of these

overseas training activities. This program initiated in 1958, provides for

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supporting the study of outstanding young medical scientists from 34

countries for periods up to two years in U.S. universities and research

institutions. During fiscal year 1961, 90 such awards were made for a

total amount of $700,000.

Support of U.S. scientists studying abroad under the sponsorship of

outstanding research scientists is a program of dominate importance in the

array of NIH international activities. In the past 14 years about 650

U.S. scientists have had the benefit of such training and research experience

in the laboratories and universities of some 40 countries. During fiscal

year 1960, 191 U.S. fellows were supported by NIH training in 28 foreign

countries at a cost of $1.2 million. In fiscal year 1961, this program

supported a total of 217 U.S. fellows at a level of $1.5 million.

Other NIH overseas training activities included a small number (34)

of trainees studying abroad in clinical areas in the amount of $270,000

and an estimated $250,000 for 7 training grants to foreign institutions.

3. Cooperation with WHO and PAHO

During the past year, NIH has worked out agreements with the World

Health Organization and the Pan American Health Organization covering the

manner in which NIH will cooperate with these organizations in the conduct

of research activities sponsored by them. Basically, these agreements

provide for preliminary planning of international research programs on a

collaborative basis and set forth the terms and conditions under which NIH

will support the special research programs of these agencies and the re-

search projects of participating investigators and institutions. Two large

research grants for special research projects have been made to the WHO

thus far in fiscal year 1961:

(a) A grant for the worldwide study of insecticide resistance and

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for control of insect disease vectors - in the amount of $204,000

for the first year, with support promised for four years.

(b) A grant for the study of bilharziasis and research into mollus-

cicides, chemotherapeutics, and diagnostic methods related there-

to, in the amount of $78,941 for the first year, with four

additional years of support promised.

A third grant application providing for the development of global studies

relating to the epidemiology of virus diseases has been approved. Applicat-

ions for support of other comparable large-scale international research

programs are expected from WHO. In its March meeting, the National Advisory

Health Council recommended the approval of a grant of 8120,750 to the Pan

American Health Organization through the National Institutes of Health for

the purpose of planning, developing, and organizing an international health

and medical research program for the Americas under the direction of the

Pan American Health Organization. This award was paid with approval by

the President. Twelve awards to PAHO and INCAP, totaling $619,000 were

made in Fiscal Year 1961. (See Tables III and IV)

4. International Centers for Medical Research and Training

This program envisages the development of a series of international

centers for medical research and training based on U.S. universities with

an overseas extension in the form of a research laboratory and training

facility.

These centerá will provide field experience and research opportunities

for U.S. postgraduate physicians and scientists and encourage physicians

and other health personnel of collaborating non-U.S. institutions to par-

ticipate in the development of health research and training resources in

their national environment.

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Each of these centers will consist of (1) a professional, schoolbased

organizational entity which would provide a stable, continuing framework

in which programs of medical research, research planning and research train-

ing may be conducted in this country, an4 which is associated with (2) a

research and training establishment oveiseas where these activities may be

pursued under environmental, ethnic, an4 medical conditiona which do not

prevail in the United States.

Applications of five American uni4ersities to sponsor International

Centers for Medical Research and Traniing had been approved for payment.

These American universities and their cooperating institutions overseas

are as follows:

University of California Institute for Medical ResearchKuala Lumpur, Malaya

Tulane University - Universidad del Valle, Calit Colombia

John Hopkins University -- All-India Institute of Hygiene, CalcuttaSchool of Tropical Medicine, Calcutta,India

Louisiana State University- University of Costa Rica, San Jose,Costa Rica

University of Maryland - Medical College at Lahore, East Pakistan

Each of the American universities has requested research and training

funds ranging from $100,000 to $500,000 per year for each year of a five-

year period. An ad hoc Committee on International Centers for Medical

Research and Training reviewed and approved these grant requests, and the

National Advisory Allergy and Infectious Diseases Council concurred, re-

commending to the Surgeon General that these grants be paid.

Of the $5 million appropriated for fiscal year 1961 to support the

International Centers for Medical Research and Training, $2,269,971 has

been transferred from the several categorical appropriations concerned to

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the National Institute of Allergy and Infectious Diseases which serves as

the central point for administering this program. The remainder of the

$5 million was used by the Institutes and DGNS for special foreign research

programs in the regular research grants area.

5. Special Foreign Currency Proram

The use abroad of United States-owned foreign currencies (Public Law 480)

permits the extension overseas of NIH intramural research programas. Such

programs, of mutual concern to the NIH and to foreign institutions and

investigators, are carried out through development of collaborative research

agreements with scientists and government agencies of other countries.

(a) Objectives

Research under this program is directed primarily toward solution of

medical problems of particular importance to the U.S. and other countries.

The availability of qualified investigators or the existence of a

unique research situation govern the choice of the host countries to be

designated for the projects.

Provision is included in most projects for training of younger scieintists

and supporting technical personnel, to augment local acientific man power

and contribute to the scientific development of the country involved.

(b) Type of Projects

Medical research may require further study or confirmation of U.S.

findings in other countries where similar diseases are prevalent. The pro-

jecta are aimed at solving characteristic health problems of both countries.

They, for the most part, include problems of infectious diseases, nutri-

tional problema and those involving large population groups where recent

developmentsin epidemiology can permit the delineation of differences in

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population characteristics, suggesting new clues to the etiology of certain

diseases. Some of the projects contemplated, of global concern, are in

the field of virus diseases, Some countries, because of the differences

in attack rates of the same diseases, offer unusual opportunities for com-

parative studies in different geographical regions.

Studies will also be continued on those diseases which still persist

in certain areas, offering a threat to those entering them, or which can

spread to other areas. The search for new biological and botanical sources

of pharmaceutical products useful in the fight against disease also will be

expanded.

(c) Policy

Selection of the research to be undertaken receives the same careful

review and scientific appraisal as is currently given all research projects

in the intramural research programs of the individual Institutes. Tech-

nical advice and scientific opinions are also obtained from competent

scientists and scientific bodies within the host countries.

No project will be supported contrary to the wishes of the foreign

country's official body responsible for the over-all planning and co-ordi-

nation of research. Such groups will continue to be used to the maximum

extent possible, to assist in the planning and organization of projects

within each country, Close co-ordination with the research programs of the

World Realth Organization will be maintained.

The funds are intended to support only additive research and will not

be used to substitute for the support which each country would normally

give to its research efforts. Likewise, these funds will not be used to

support projects which would normally be elegible for support from dollar

appropriations.

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Public Law 480 funds for medical research were appropriated in 1961

($3.7 million) and 1962 ($5.1 million). A modest request for additional

funds has been submitted for 1963 ($610,000). Tables V and VI reflect these

appropriations and the 1963 request by country.

Funds provided in the Fical Year 1962 appropriation to support this

program are not yet available for obligation and expenditure, as the formal

apportionment request has not yet been returned to us through budget channels.

The negotiation of individual agreements supported from Fiscal Year

1961 funds has proceeded rather slowly. Scientific and administrative NIU

personnel have traveled to the countries where research is to be conducted.

Preliminary scientific agreements have been reached, but the administrative

follow-up to obtain official signatures has been slow. It is believed that

it would be appropriate at this point to allow ourselves a period to evaluate

the effects of this program on the scientific communities of the host count-

ries before additional funda are requested.

Because of the difficulties involved in the administration of this

program, the NIH now is considering a new approach to the utilization of

funds to be provided for future year i.e., that collaborative research

programs be negotiated in general terms with the appropriate scientific

bodies of the governments in host-countries. These national bodies willI

then develop specific program proposals which they will submit to the NIH.

The proposals will then be reviewed. If acceptable, formal documents will

be prepared and official signatures obtained in order to release the funds.

The NIH Advisory Committee on International Research has indorsed this pro-

posal.

(d) Summary by Country

BRAZIL - Authority to obligate funds in the Brazilian appropriation was not

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received until August 1961. Following this, NIH representatives conductedpreliminary negotiations in Brazil in October 1961. A scientific negotiat-ion team is leaving for Brazil December 2 and it is expected that threePublic Law 480 research agreements will be concluded shortly. The proposedagreements include studies of schistosmiasis, use of venoms in cancerchemotherapy, and possible use of botanicals native to Brazil in the treat-ment of heart disease. Brazilian cruzeiros have decreased in value fromthe time of allocation to the 11resent to the point where our purchasingpower from the 1961 allocation is about 50% of the value at the time: of -allocation.

Excess foreign currencies were not available for request by NIH for1962 or 1963; however, we will seek additional funds in this country in thefuture.

BURMA - Preliminary contacts have been made with acientists in Burma; however,the government negotiations have not yet been begun. This should be accom-plished within the next 90 days. Projects to be developed with scientistsin Burma include research in fields of nutrition and malaria.

EGYPT - Three research agreements, concerned with various aspects of nutrit-ion and anemia, were negotiated last June by NIH representatives. Thesewere transmitted to Egypt in August for signature.

One has been signed and the funds have been obligated. The other twoare in the process of being signed. We have requested follow-up on the twounsigned agreements from the Embassy and NAMRU-3 and expect information ontheir status in the near future.

Projects proposed for support for the current fiscal year include re-search in schistosomiasis, bladder cancer, intestinal helminths and oph-thalmologic studies.

INDIA - Four research agreementa totaling $1,226,000 were negotiated by anNIH team in August 1961. They have been signed by the collaborating Indianscientists and are now in the process of getting final clearance by theCouncil on Scientific and Industrial Research and the Ministry of Finance.We were informed early in November that Professor M.S. Thacker, Director ofCSIR, was ready to sign the firat agreement concerning nutrition; the secondagreement, which is dependent upon the first, is ready to be signed as soonas the first agreement is effected. Two other agreements in the cancerfield developed with Indian scientists are as yet unsigned.

All projects negotiated in India so far are with scientista in institut-ions coming under the direction of the CSUR. However, NIH has proposed pro-jects with institutions controlled by the Ministry of Health and NIH re-presentatives have held several preliminary discussions with the Ministerof Health. So far the Health Ministry has not been willing to endorse thescientist-to-scientist negotiations.

Funds appropriated for Fiscal Year 1962 are designated to support pro-jects of material interest in periodontal disease, tropical medicine, virusdiseases, neurological disorders, cholera and malaria.

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INDONESIA - Negotiations have been started in Indonesia for two projects;studies in mycology and nutrition. The GOI has not as yet indicated theirwillingness to allow their ecientists to enter into agreement with NIH, butinformation received recently indicates we may get official acceptance soon.We have not requested additional funds in Indonesia beyond those providedin 1961.

ISRAEL - Negotiations have been completed and work has begun on two researchprojects in Israel. One is an Epidemiologis study of Rypertension andIschemic Heart D3$ease ($100,000 equivalent) and the other is on methods ofmeasurement of O0w ($70,000) equivalent). Travel support for Americanscientists to attend a genetics research symposium in Jerusalem was alsoprovided from these funds.

Studies in various neurologic and ophthalmologic disorders, atherosclerosis,toxoplasmosis and psychological investigation of infant behavior are pro-posed for support from 1962 funds.

PAKISTAN - In May and June 1961, an NIE team negotiated a nutrition surveyagreement in Pakistan. This agreement is now in force and the initial pay-ment has been made. A second agreement for cholera studies is dependantupon final agreement on the organization and status of the Pakistan-SEATOCholera Research Laboratory. This agreement is now in the final stages ofrenegotiation. Additional support is requested in 1962 for similar programs.

POLAND - A negotiating team has just returned to NIH from Poland bringingwith them a number of negotiated projects. These are currently being preparedfor review by the Office of the Director, NIH. Polish scientists have in-dicated a desire to collaborate in studies of hypertension, brain-behaviorresearch and encephalitides with the funds that will be made available in theFiscal Year 1962 appropriation.

YUGOSLAVIA - Scientist-to-scientist negotiatione have been completed on alarge epidemiological study of cardiovascular disease in Yugoslavia. Thisproposal has not as yet been approved by the government officials of Yugo-slavia.

For support from Fiscal Year 1902 funds, projects have been proposedfor study of pellagra and anemia, arthropod-borne virus diseases and neuro-logical disorders in infancy.

6. NIH - SEATO Cholera Research Program

The NIH is collaborating with the Southeast Asia Treaty Organization

(SEATO) in the developmeñt of a cholera research program. Although cholera

is fortunately no longer a disease threat in our country, it is a major

one in other areas of the world. In May 1959, the SEATO Council initiated

a program looking to the eradication of this disease through cooperative

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research by scientists of all the SEATO nations. The Council allocated

$400,000 from the Asian Economic Development Fund for this purpose. The

National Institutes of Xealth was asked to administer the program. In the

comparatively short time since initiation of this forward-looking program,

a laboratory has been established in Thailand and has functioned for almost

a year. Now, another more permanent laboratory has been created in Dacca,

East Pakistan, which was formally open early in December 1961. Some 50

leaders in cholura research and control from SEATO and other nations

gathered in Dacca for a conference on cholera. Epidemiologic, laboratory,

and clinical studies will begin this year.

C. THE IMPACT OF NIH INTERNATIONAL PROGRAMS ABROAD

Although a systematic and thorough appraisal of all our foreign opera-

tions has only been recently initiated, certain preliminary conclusions

seem warranted. We have considerable evidence that the research being

supported is generally of high quality. For this reason, we have con-

cluded that the individual projects are accomplishing effectively the

objectives of the NIH. These foreign activities allow us to bring to bear

the talents and skills of highly competent foreign scientists on the health

problems of the United States. Thus, NIH is now taking advantage of a

vital resource which otherwise would not be available.

On the other hand, we recognize that because of the rapid growth of the

program, its aggregate effects may in certain countries influence the

development and structure of medical science. Usually these secondary

effects are advantageous in that they strengthen the research potential

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and productivity of the recipient country. However, we have recently had

experiences which show us that under certain conditions our actiona may

innocently interfere with the orderly development of the programs of foreign

institutions or even foreign countries. Thus, we perceive the need to assess

continuously both the primary and secondary effects of our actions. It is

recognized that while NIH programs are not designed primarily for the ad-

vancement of our foreign policy, they must be sensitive to the needs for

maintaining satisfactory relationships with foreign scientists, foreign

institutions, and foreign governments.

Our attention has only recently been focused on the secondary effects

of our overseas programa because until very recently our foreign activities

in the aggregate did not constitute a significant part of the total research

support structure of any country. Because of the increasing feasibility

and desirability of international cooperation in medical research, our

foreign activities have been increasing rapidly. They still represent only

a small part of our total effort, for example, only about 4 percent of our

grants are awarded in foreign countries. Nevertheless, in fiscal year 1961,

506 grants were made to foreign investigators and the total support amounted

to 8.2 million dollars. Even though we have been very selective in our

awards during fiscal year 1962, it is expected that about 12 million dollars

will be awarded to foreign investigators. These scientists are doing

important work which we believe will advance the status of the health

sciences in the United States as well as in the country of the investigator.

In several countries (Canada, the United Kingdom, Israel, Sweden, and Japan)

our support now ranges between one and two million dollars yearly.

One of the important functions of the new Office of International

Research and ita overseas representatives will be to provide a continuous

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appraisal of both the primary and the secondary effects of our activities.

Attempts will be made to assure that the NIH contribution to research

overseas is provided in such a way as to insure that it will add to or

stimulate local support rather than replace the research investment of the

foreign country. The NIH overseas activities have been .undertaken only in

instances where such projects were in the interest of our domestic object-

ives. Nevertheless, our willingness to cooperate with and support other

countries in a mutual effort to inprove the health of their people and our

people furnishes an excellent opportunity for collaborative research. These

programs will increase our knowledge only if they are scientifically pro-

ductive and only if they are supported and respected by the leaders in

foreign medical science. For this reason, we are establishing liaison with

appropriate representativesin those foreign countries where our activities

might affect significantly the status of medical science in that country.

In consultation with foreign scientific groups, we are studying the status

and goals of the health-science programs in these countries so that we may

be sure our own projects supplement or complement their programs. In meet-

ings during the past year with the leaders in medical science in Sweden,

the United Kingdom, France, Israel, and Canada, we have learned that our

programs have resulted in significantly mutual advantages. These discuss-

ions identified way in which the future programs of NIH could be coordi-

nated more effectively with the total research efforts of these foreign

countries.

We have recently assigned a full-time representative to the World

Health Organization in order that we may have available to us the vast

amount of information in that organization in constructing our own inter-

national programs. We are using a variety of other mechanism for studying

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the relationship between our own foreign programs and those of other

American and foreign organizations. For example, we are cooperating with

the American Institute of Biological Sciences in their attempts to compile

information concerning research resources abroad. Close relationships-- -

have been established with the Office of the Science Adviser of the

Department of State.

On December 15, official representation was established in Paris,

France through the assignment of two NIH employees who have been accommo-

dated and space provided by the Embassy.

Continuous on-the-scene appraisal of our programs will permit us to

choose selectively those activities best calculated to advance our mission

in the most effective and economical manner. In addition, administrative

advice and assistance will be provided to grantees and to the various

Institutes and the National Institutes of Health. The science-administra-

tors appointed to these positions will also have the responsibility of

negotiating research agreements in connection with our Special Foreign

Currency Program in those countries most easily accessible to their base

of operations.

Since the primary objective of the NIH international program is to

advance the status of the health sciences in the United States, our grants

are most frequently made in countries where adequate research resources

are available and where original and productive ideas arise. This means

that NIH relationships have been most extensive with the countries which

are more advanced in the medical sciences, such as, Canada, Japan, Australia,

Israel, and the Western European countries. The fact that we do not

frequently support scientists in newly-emerging countries also recognizes

that their limited scientific manpower must not be diverted from the high-

- 21 - RES 1/10

priority problems of that country by our support of projects of interest to

us. However, NIH does have programs in emerging countries which are

supported with U.S.-owned foreign currencies. We have been careful to

develop these programs in such a wayas to assure that (1) the projects

supported were of interest to both American and the cooperating country

and (2) the project involved collaboration between foreign investigators

and U.S. scientists. In this way, we assured that the project would not

only achieve its primary objective but, in addition, the collaboration

would tend to elevate the level of science in the cooperating country.

The International Centers for Medical Research and Training which are

being established through grants to American universities have been care-

fully studied in respect to their impact on the medical environment in

which they are located. Suffice it to say that they will strengthen the

medical research potential in the foreign countries in which they are

located. However, we perceive the need for continuous appraisals to make

certain that the participation of foreign scientists in the work of these

centers does not significantly reduce the number of medical scientists who

are available for other important work of the country, such as teaclhing

and medical services. For this reason, we plan to evaluate not only the

research accomplishments of these centers but also their effects on the

medical environment in which they operate.

Thus, it is becoming increasingly apparent that the development of

highly effective international programs will require a careful continuing

appraisal of the relationship between our activities and those sponsored by

and planned by the foreign scientific community. Our experience to date

suggests that by making such an effort we can be sure that our international

research activities accomplish not only our primary goals but also that they

strengthen the medical research potential of the cooperating countries.

.o. .X u0 X X, 0 0 X 0 X g 0 .0h0 0 .o 00 4 00 LO 4 O 0W e 0 F

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04 LO LO ~ ~ ~ ~ ~ ~ ~ r - 00 l

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0.

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dw

TABLE IIARGENTINABUENOS AIRE

Buenos Aies, Una~y of

De Robertis, E .... .... Ultrastructure of synaptic endings ..-.. í-..n.-..- .Mancint, Roberto E --- Distribution of pituitary hormones In the rat.....Paladlna, Alejandro -... Angiotensln In experimental and human hyperten-

sion.Institution tobL 3 grants, $19,500

Instituto de Biolo<ay Medicina Expeiment

Ioussay, Bernardo A... Role of endocrine gland in p3thological conditlons.Institution total, 1 grant, $15,000

BUENOS AIRBS-C~.daiul

Instituto de Investig nes Bqulmlcas Fundadon CaMne

Leloir, Luis Y-F_ . .... Enzymes and coeo~ mes acting on hexosephos-phates.

Institution total. 1 grant, $12,200

Instituto Modelo Lb Agote-Univeraity of Buenos AIes

Soto, Roberto J ... _... A study of iodine metabolsm of goiter in Argentina.Institution tot, 1 grant, S2,3GO

Ramos Mejia Hial

Cabrini, Romulo L __-. Acid d a alkaline pbosphstase in seorbutie wounds_Institution total 1 grant, $3,295

CORDOBA

Instituto de Imnesi~dn Medifa Mercedes y Martin Perrmey

Taleisnlk, Samnuel...- . Regulation of parathroid funetion .......Institution total, grant, $2,500

STATE TOTAL, 8 grants --...--...-.-.-.. .. . . --

AUSTRALIAADELAIDE

Adelaide, Unlverdb~ eMaxwell, George M -_ Metabolism of the canine and marsupial heart....Rowley, Derrickk _. . .Role of opsonins n susceptiblicy to infections ..

Institution total, 2 grants, $42,797

CANBERRA

Commonwealth Sdeil~ asnd Industrial Reeh OrgantationDay, M. F _ ...- _- Multiplication of an insect polyhedron virus.......

Instltutlon to~ , 1 grant, $3,880

MELBOURNE

Melbourae, Univeryb '

Burnstock, Geoffrey .. Autonomic nerve-smooth muscle transmission....Gibson, Frank W..... Metabolism of aromatic c-,mpounds by micro-

organisms.Rose, Samuel.-... .... Continuous microinjection in cancer and biology....White, Miechael J -.. ... Insect population genetic--ereerosis and epistasis..

Institution total, 4 grants, 98,I527

Walter and Eliza Hal] lstituteNossal, Oustav J -. ..... Genetic studies on lmmunolotically competent cells

Institution totl, 1 grant, 34,729

SYDNEY

Sydney, Unibveroty o'

Freeman, Hans C .... _.- Crystal structures ofsome metal-peptide complexes.Suteliffe, John P _....- _ The relation of imagery and fantasy to hypnosis....

Do - . .........do .-----------------------Instltution total, 3 grants, 30,144

STATE TOTAL. 11 grants .- . ............. -- -------------

B-1549C3.-....A--4220...-.....H-5153 ---------

8184

C-4745C2 ...... 18

G-3442c....... 26

A-4728 -...... 34

D-1155C1 ..-.. 8

RF-3 .-----. s58 2,500

-............--- s"s -54,795

H-s,466 .......E-3225C1 .-. - 13

E-2462C2 .-. . .. 17

B-2902 ......- . 9A-4632 ....-.... 2

C-530 ........ 120-7212 .---. 29

E-3958 ......-... 29

A-340CI.....- 1M-3950- ..... 21M-395081 - 21

d . _ _

1-'e1

=

10, 0006,0003,500

16,o000

12, 200

2,00

3,295

_ I

i

i

. 1

i

17,79725,000

3, 80

22,00027,065

39,07010,392

34,729

15,74914,035

3e0

210,047

1

_1 -______~- ------- ----------------- - * --- ---- ------------------------------

.

4. Research Projects Grants

Invesligator Project title Grant No. S.S. Dollars

AUSTRIA

VIENNA

Vienna, Universily oflHolzner, Johann H ..... Hi-stoehl(mitrv f' ihe human liver........... ..lPiffi, Eduard ........... Card index < f the oribatid imites of the w-orld ......Preinlng, (Jthnm.ar........ Studies on aerosols. - -Seitelherger, Franz...... Sitdies on I gmnients of hrain stem-rallidum, zr,

s n.Institution total, 4 grants, $29,100

R F-4 SSE-3499 I...... IRF-7 -- : - 2NB-2548RI S - 8

STA TE TOTAL, 4 grants .....-..-.....-.. ......... - ............ ...... .

BELGIUMANTWEBP

Institut Bunge

Lowenthal, Armand ..... Electrophormtie smlzdy of cerebral tissue proteins....van Bogaert, A .... ..... Pulmonary arterial and cardiovascular eflects.

Institution total. 2 grantq, $22,145

World Federalton of' Neurology

Gozzano. IMario -..-.. . Neurology and neuropathology international con-gresses.

Do ...-.......... do......................van Bogaert, Ludo ------ International r.eurological research implementation.

Institution total, 3 grants, $170.l1O

BRUSSELS

Brussels. LUniversity of1)esmedt, Jean E ...-... Neural mechanisms in acoustic perception .....Dumont, J. E....--..... Thyroid energetie metabolism and its contiol -....Errera, lMaurice L ..... Innluenee of nuclear damage on cell metabolism ---


Institut Jules Bordet-Unrversity of BrusselsTagnon, Benry J ....... European breast cancer study group............

Institution total, 1 grant, $9,890

GHENT

Chent, Univerlty ofDenuee, J. 1......... Orígin and funetion of serum proteins in Inverte-

brate.Heyrmans. C'-- ----.... Basoceptors in hypertension, hypothermla, iung.-.

lnstitution total, 2 grants, $20,100

LIEGE

B-2316C1 ---- 8H-6012 ...-.... 4

B-2761 ......- 96

B-276181. .-.-. 96B-2420-C2-.. 41

B-2482CI1 .-. . 30RF-10 . ........ 58G-6214C2 .---- 27

C-4896 -....-.. 12

A-5048 ....... 13

H-3393C3 --.-- 4

Institute for Experimental TherapeutiesDallemagne, .Mareel .... Biochemistry and physiology of bone and teeth .... D-87801 ....... 33

Institution total, 1 grant, $3,2.0

LOUVAIN

Louvain, University ofHeremans, Joseph F .-... Metabolism of gamma globulins in liver disease .-- A-4263 ......Hers, Henri O------ G A biochemical study of glycogen storage disease ..- A-4053CI ...Vandenbroucke, J ...... Function ofgastroesophageal and ileocoliesphincter. A-3987CI . -

1nstitution total, 3 grants, $38.500

228

22

STATE TOTAL, 15 grants .... ........ .... _ ...................

$2, S7.2,3002.875

21, 8.80

29.900

7. 82014.325

30, 00C

14,000126,190

14.0002, 4373,631

9, 890

11,100

9.000

3.250

19,40011, 50072, 13O

284,143

y I1

1

-oi

Listing by Geographic Areo and Grantee Institution

Investigator Project title Grant No. S.S. Dollars

BRAZILRIBEIRAO PRETO

Faculty of Medicine of Ribeirao Preto-University of Sao PauloDe Almc(;ia, Jose O..... Immunological studies on human and nmurine

leprosy.Rocha e. Silva .M ...... .Bradykiniin n eentral nervous system phenomena.

Institution total, 2 grants. S7,500

RIO DE JANEIRO

Brazil, University ofChagas. Carlos -.--..-- Study of the meechanism of curarization - ........----l.eao, Aristides A ....--. Electric and chemical aspects of spreadine depre.s-

E-3760 -.O-..... 24

-2952 ----- - 14

Bi-1471C -- - 14B-2219C1 -- 3

sion.Institution total, 2 grants, $22,450

Instituto de Biofisica, University of BrazilDe Carvalhoa, P .- -.... Studies on the atrioventricular node of the heart .. H--5148C1 ....


SALVADOR BAHIA

Bahia. University of

Andrade, Zilton A.....- . Patholongyof the liver in human schistosomiais.s..Institution total, 1 grant, $2,875

SAO PAULO

Faculty of Medicine-University of Sao PauloEichbaum, Francisco .. Neural mechanism of cireulatory fallure in diph-

theria.'Raw, Isaias-.......... Studies of electron transport enzymes-.............


Instituto Adolfo LutzLopes, Oscar S-.......... Studies on arthropod-borne viruses in Sao Paulo.--


9

RF-17 .---- 58

H-5477 .-...- 14

G-7940 -. . 2

RF-I-. ... 58

STATE TOTAL, 9 grants - . ..... ............ 103,495

CANADA

EDMONTON

Alberta, University of

Kay, Cyril M ---------- Secondary and tertiary structure of proteins .....-Palmer, Keith H -.. . Taxaceae-the structure of the cardiotonic com-

pounds.Uhl, Charles N ...-..... A prellminary study of multiple-stimulus learning..


FREDERICTON

New Brunswick, Unlverlsty ofPaivio, Allan U ...-... .Personality factors in reactions to observers ....


GUELPH

Ontario Veterinary CollegeMustard, James F ..-.. Phosphollplds, blood coagulation, and atheroscle.

rosls.Institution total, 1 grant, $19,600

A-411001- , 2H-5310RI ..-. .89

M--4894A -..... 60

M-4188 -.... 23

H-496401 6 ...

$17, 2IA1

20t, 2. 0

1 9, 0003. 450

8. 740

2,875

17,430

12,000

2,500

i

5,75018,050

2,200

19, 60

4. Research Projects Gronhs

Investigator Project title Grant No. S.S. Dollanr

CANADA-ContinuedHAMILTON

MeMaster Unive~btyBlack, Abraham H -. .... Conditioning under curarellke drugs .....-..... M-2741C2 ..... 36

Institution total, 1 grant, $1?,132

KINGSTON

Queens UnverdtyJones, John K -..... . Carbohydrate-protein compounds of anlmals ...-. A-4127C1 .--- 2WVest, A. S ....--------- Reactions to iFsect bltes--causes and eflects -..... .E-1155C4 .--- 17


LONDON

Western Ontario, Uiversity of

Brown, A. W ..-. Studies on the insecticdes-resistance of mosqutoes E-2320C2.... 17De Mayo, PaulJ -...... The constitution of griseovirlidln ......-........ .E-3317RI ..... 89


MONTREAL

MeGill-Montreal General Hospital Researeh Institute

Quastel, J. H.E.. ....... Effects of aliphatle alcobols on tissue metabollsm_. B-2132C2 -.... 26Institution total, 1 grant, $13,800

MeGfIl UnlversttyBeckl, John C ........- Metabolic effects of growth hormone In man.....Bindra, Dalbir .......- Interactlon of habit strength and drug effects.......Blank, Fritz -... . ..... Chemistry of constituents of dermatophytes.......Cleghorn, Robert A -.. . .Metabolism of amines in relation to mental lllness_.Fairbaim, Donald ------ Blochemistry and physiology of Asceria lumbri-

coides.Do - . .................do...................

Gliroud, Claude J ---- Mechanisms of aldosterone biogenesis.............Hebb, D. O0 -_.... . .... Studies of learning, perception, and motivation.Hollenberg, Charles ..-.. Hormonal effects on Lipid metabolism..........Hosein, Esau A. -. ..... Neurophystologic effects of gamma butyrobetalne..

Do ..-... do.................-Langman, Jan -... . Formation and localisatlon of lens antigens in man_.Lowenstein, Louis .----- Anemia and nutritional defcieneles in pregnancy_Malmo, Robert B -... Speclfielty of physlological reactions to stress ...Mason, S. Oa....-.... The rheology of blood ..................McKenzle, John M ..... Investigation of the pathogenesis of hyperthyroldlsm.Metrakos, Jullus De .... Oenetics of the eplepstes.......... .......Míilner, Brenda .......- .Study of learng and perception in brain-damaged

man.Rose, Bram ...-..... .Hypersensltivity mechanlsms in man.........Scriver, Charles R ...... Genetlc, coenzyme, and transport factors in metab-

olism.Sehoni, Alec ..-... ... Physlochemleal studies of antigen-antlbody sys-

tems.Sheldon, Huntington .... Connective tissue cells In scurvy and rickets.....Solomon, Samuel -.... .In viro and in DiUro metabolism of sterold bormones_

Do ...-.......... do................Timel, Tore E ...-..... The acid hydrolysis o glyeuronosldle bonds..-.....Vennlng, Eleanor H.-... Mechanisms In the secretion of aldosterone....

Instltution total, 26 grants, $454,897

Montreal Genel r~HopialMcCallum, J. L ..-...-.. Aetiology of apbthous leslons of the mouth.. ....

Institutlon total, 1 grant, $2,000

G-7402C1 .-M-3238C1....I.E-4050 ......M-30001 ------E-2138C2S2....

E-2138C3 ...-A-4295 ......M-2455C2.....H-5282 -......--B-1756CISR.._B-1756C2 -....-B-3245 ..-...--A-5200 ---..---...M-1475C4 ----H-5911 ----A-4121C 1---B-706C6 ...-B-2831-........

1851405117

171836331414136

3611182936

E-1322C4 -.... 13A-5117 -....... 33

E-2085C2 .-... 13

A-4422 ---A-4329. ---.-A-4329SI1 .-...A-4258 .....H-2n6C4 ---

2718184018

DI3 81----- 5

.

$12,132

8,39520,125

10,0009,752

13,800

47, 42114, 26013, 90025,4346,807

24,46019, 86711, 50

9, 7756,267

13,16715, 41023,00016,67511,38510,62620,2228,165

17,00014,000

-31,450

17, 91024,15428,15212,0009,890

l~,

,

,

i

r

.

Lisling by Geographic Areo and Grontee lnstitution


CANADA-ContinuedMONTREAL-Continued

Montreal, University of

Adamkiewicr, V. W.... Insulin sensltization to anaphlactoid inflammations.Do ....-......... ... do....................

Isler, Henri- ........ Thyroid tumor production by a low iodine diet....Selye, Hans ........-... .Experimental morphology of skeletal structures..

Do -....... H... - lormones, electrolytes, and the nervous system....Do ...-...... ...- The mechanism of acute infarctoid cardlopathy...-Do ..............-.. do .... :..............- -


Notre Dame Ho~ilal

Lanthier, Andre -.. M.. . .letabolism of aldosterone in vito and in vivro......Do .....-.... .... Androgenic steroid by synthesis ovarian slices.....

Institution total, 2 grants, S22,720

Royal Victoria Hospital

Kalz, Frederlck .....-... Investigation of caplllary permeabliity In humanskin.


Third Worid Congress of Psychlary

Cameron, D. E .....-.. Thlird World Congress of Psychiatry .......Institution total, 1 grant, $75,000

ONTARIO

University of OttawaBohatirchuk, Fedor....- Dynamics of bone aging......... ...............


QUEBEC

laval Univesalt

Fortier, Olaude .....- . XNeurohumoral control of adrenocosticotropbic activ-ity.

Lamarche, Guy .-.-. . DUnit study of trigemenal afferents in the monkey.-Institution total, 2 grants, $24,044

SASKATOON

Saskatchewan, Univerlsty of

Agnew, J. N-.. - Performance as a function of drive level.......Do .--.-...... . -.-- do .......-.. . .........

Altschul, Rudolph .-.. _ Heme compounds and cholesterol metabolism ...Drance, Stephen M .- Ocular hypotensive effects of anthranilie acld......Jaques, Louis B ...-.. Spontaneous hemorrhage with antlcoagulant drugs.Sutherland, O. B - .---_ .4naphbylactic responses in blood and smooth muscle.Woodford, V. R., Jr- ...- Enzymatic mechanisms In catechol-amine biosyn-

thesis.Institution total, 7 grants, 380,493

TORONTO

Ontario Cancer Instituta

Ham, Arthur .....-... Relation of virus to tumors in animals and man ....Institution total, 1 grant, S58,104

Toronto, Unversity ofBest, Charles H .------- Choline, methlonine, and fat metabollsmr......Movat, Henry Z .-. . .... Electron mlcroscopy-ecute glomerulonephrltls -.-Poyton, H. O ._-..----- FPilm contrast evaluation-dental X-ray film defini-

tion.Slmlnovitch, Louis ..- . Marsmmalan cells and viruses cultivated in ~itro...


A-2260C2 -.. -A-2260C2S ....C-5489 .....A-1641C2 ...-B-2037C2...H-3688C3 .....H-3688C3S1...

88

1827888

A-4327 .---- 18A-4330- __- 18

H-5226..-..... 22

M-4324 ...-.. 96

A-2298C2 ...-. 22

B-2827 -... . .18

B-3200 - _--- 3

M-3612C1- ----M-3612CS11...H-4568C1 -....B-2714 ----H-4877C1 ....H-5795 ..--...-A-3812C1 ..-..

363633306

1334

c_49MC1L--..- 25 38,104

A-3523C1 -_ 34H-5657 ...... 8

D-1325922 ......... 231

e

9, 9019,200

14, 72034, 50u39,10032,400

2, 100

16, 7525,968

75, OU0

9,215

17,432

6,612

13, 2656,5008,3381,800

24, 15014,95011, 00

19,00013,110

405

16, 600

e

4. Research Projects Grants


CANADA-Continued

TORONTO-Continued

York UniversityCoughlin, Richard J.-... Rep(roduction and birth in Asia -0....... . .. G-8237-:-...-..


VANCOUVER

British Columbia, University of

Band, Rudolph N ...- . .. Physiological Investigations of IJartmannellid am- E-3749 .-....oebae.

Dolman, Claude E .-.-- Essays in the history of bacteriology.-..--.. - E-3625 .-...Dutton, Guy G -.... . .Structure of synthetic polysaccharides ..-....... 0-7652......Finnegan, Cyril V -. .. .. The differentiation of the hypomere in slamanders. 0-6178CS1..I

Do ...-......... ....do......... -.. 0-6178C2 ..... .Kutney, James P ..-... .Synthesis of sterold analogs ......-.... ... C-5037 ......MeGeer, Patrick L - . Analysis of aromatic urinary compounds --. 1.. ... H-s564 ....-Stein, Janet R .....- . .Genetics and cell differentiation in gonlum -.... .. 0-7213 ....-Tener, Gordon M ......-. The isolation and identification of polynucleotides._ C-5342 ......Wada, Juhn A ...- . Chronic focal epileptogenic lesions and structures.. B-2812 ...-....


Technological Station Fisherles Research Board of Canada

Idler, David R ....-.. .. Sterois of marine invertebrates a-_ ._._. ............ A--4490 ......Institution total, 1 grant, $8,092

WINNIPEG

Manitoba, University of

Chown, Bruce .-...... .. MNaterno-fetal barrier and Rh .-... ---- H-3238C3....Frank, George B .......- Pharmacological studies on isolated cerebral cortex_ B-2647 .......Hagen, Paul B .......- .Pharmacologic studies on the autonomic nervous B-2282C1I.....

--system.Labella, Frank S ....-.. Reactivity of tissue glycoproteins -. . .......... --_ 0-7404 ......


CHILESANTIAGO

Chile. Unlverslty of

Agosin, Moises -...... Metabolism of Echinococcus aranulosus .............Do -........ . ......do ...........- -

Cori, Osvaldo ...-.. . .Biosynthesis of phosphocreatine and phosphoargi-nine.

Neghme, Amador -.... Insecticide-resistance in TDiatoma infestans .......Rojas-Villegas, F ....-.- Race and diet as factors in atheroselerosis in Chile..Yudilevich, David L ..-- Transcapillary movement by multiple tracer meth-

ods.Institution total, 6 grants, $39,175

Instituto de Neurocirugia e Investigaciones Cerebrales Chile U

Martinez, Alfonso ..-.. Electronmicroscopie study of cerebral vessels inman.


Fundacion Lopez PerezRaventos, Enrique-.. -- Chemistry, immunology of urinary proteoses In

cancer.Institution total, 1 grant, $16,330

E-1867C3 ..-. .17E-1867C3S1.... 17G-5631C3 .-.- 26

E-2300C2 ...- .17H-4354CI.-.. 38H-5929 -... ---- 9

H1-5172 .--- - 8

C-5541 --- 18

STATE TOTAL, 8 grants---- ._-_..._. .._. · ,_,___, .......,........ -.

23

17

9389272789142923

e

11,788

5,50013, 6272,8007, 3'05,0009,2007,411

23,7407,300

26 8,092

7 13,76514 11,50014 14,000

2 4,600,

---$1, 198 556

i ·

.e

, i

2,100525

7,000

4,4006, 950

18,200

9, 430

16, 330

64,935

1 ' I ,eu g-- --- -- ------ ------ ------ ------ ------ ------ ------ ------ ------l1Al J I U

Listing by Geographic Area and Grantee Institution


COLOMBIA

BOGOTÁ

I ospital de San Juan de DiosLichtenberger, Egon .... Study on atherosclerosis in Colombia- ...... H... -4538C1 ...... S 1,800


MEDELLIN

Antioquia, University of, Medical School

Latorre, Guillermo -.... Renal ischemlia and changes in body comniposition.. 11-5136 .-..... 9Institution total, 1 grant, $6,903

6, 903

STATE TOTAL, 2grants .....--..................-........... 8,703

COSTA RICA

SAN JOSE

Costa Rica, University ofZeledon, Rodrigo A ..... Comparative physiology of leishmania .-. ....... . E-3304RI -.... 17 9.545


STATE TOTAL, 1 grant .........-......... : 9,545

DENMARK

AARHUS

Aarhus University Medical S&hool

Skou, Jens C ..-.... Enzyme system relationship to active transport ofion.


COPENHAGEN

Copenhagen, University ofAndersen, S. R ......-.. Investigation of histogenesis of retinal tumors......Kemp, Tage . ........... Heredity in certain types of cancer .................Maaloe, Ole U -.......... Role in protein synthesis of bacterial ribosomes --..Ussing, HansH --------. Physiology ................- - - -


Copenhagen University, Hospital of

Killmann, Sven-Aage.... Pyrimidine uptake by normal and leukemic leuko-

B-3253 .......

C-4649C1 .. -C-948C12 ....-E-3115C1......H-6637....

C-5492 .....cytes.


Technical University of Denmark

Dani, Henrik -------- -- Experimental cholelithiasis -........-..... A-4964 .....Institution total, 1 grant, $9,975

University Clinic of Paediatrics-University of CopenhagenPlum, Preben - -...-.... .Multidisciplinary investigations on cerebral palsies. B-2408C2-....


Danish Cancer Registry

Clemmesen, Johannes-_. Danish and International Statistical Cancer Review_ C-3087C4 ....Institution total, 1 grant, $18,900

Danish College of DentiatryBjork, Arne .....-.... .Facial growth studies with metalllc implants....... D-843C2 ...Jorgensen, Knud D...... Crystallographic study of dental gypsum .......... D-842C2.....Pindborg, Jens J-.-..... Studies in oral leukoplakias .-....... ... D-1358 .....


2 3, 500

8 3,80029 8,602

2 8809 12,000

6 4,725

33 9, 975

53 6,900

8 18, g00

5 3,3005 3,8005 7,130

e

1/

.

i

1j.

ii

1 �iIb1

1i

- i 0. i

i1

_se.

. 4F

i lJ -

4. Research Projects Granfh


DENMARK-ContinuedDanish TB Index

Groth-Petersen, E ...- . .Epidomiologic basis of tuberculosis eradicationDo ...-...... do _........ . ......


Gentofte Hospital

Christenson, L. R.... ... Biochemistry of thyrold hormones .......Institution total, 1 grant, $2,500

state Serum Insttute

Slim, J. C .-..-..-.-. . .Studies on acquired toxoplasmosis. - _... .....Institution total, 1 grant, $8,782

Tuberculosis Immunization Research Center

Sorkln, Ernest .......-.. Detection of antibodies in tuberculin aller~ gyInstitution total, 1 grant, $14,030

STATE TOTAL, 17 grants -_ ...................

E-3182C1 . --.. 15E-3182CIS .... 38

RF-18 ...-... 58

E-1741C2 .---- 17

E-254702 -- 13

EL SALVADORSAN SALVADOR

El Salvador, University of, Shool of Medcidne-Rodriguez, Maria I ....- Intraventricular conduction in manmmalan heart...

Institution total, 1 grant, 331,604H-5475 ------- 9 31, 604

STATE TOTAL, 1 grant . ..- - ----------------------------------------------

FINLANDHELSINKI

Helsink,. University of

Eranko, Eino O -- _----- Funetion of adrenal medulla........Holsti, Paul ..-. . .Bile acids as cause of liver injury ..................

Do .-..... . .Enhancement of tumorigenesis by ree fatty acids.-Makela, V. E ...-.... Genetic studies of antibody and antigen synthesis..Oksala, Tarvo A ...- . ... Chromosome pairing and segregation in Drosophila.Setala, Kal .-...... . Mechanism of carcinogenesis In mice and rabbits...

Do .......-.. . .Mechanism of experimental atherogeneslis.......Toivonen, Sulo I ..-.... Inductive agents in normal and malignant t'isues..Vonbonsdorff, Berte .--- Vitamin B" deficiency in tapeworm infestatlon..-..Wager, Odd .....- . ..... Serological studies in rheumatoid arthritis .--....


Institute of Oetupational Health

Juurmaa, Jyrki Y ..-... The ability structure of the blind and deaf ..-L-..Karvonen, Martti 3J .-.. Epldemiology of heart disease in Finland .......


TURKU

Turku, Unlverlt of

Hannah-Alava, Aloha -- Cis-trans position efect betweennonallelicloei ....Vfilkki, Panu .....- . .... Studies on phosphollplds of thyroid.......

Institution total, 2 grants, 265,767

STATE TOTAL, 14 grants - ..-... .......

A-1725C3 -....A-4443. .....C-462101...RF-8 -.---G-6780C1....C-2930C4 -----H-4572C01..I..C-347. -------..E-1693C3 .----A-3026R1 .....

1888

58292733271722

M-3593C1 ...-. 21-4754C1..... 34

0-6754C1 ...... 29A-4773 --- - 18

S20, 505,247

2, 500.

8,782

14, 030

134,621

e31,604

8,05018, 7506, 9002,8758,0509,200

12,42020,000

, 6007,400

4,2605,000

, 76720,000

135,162

----------------------

.. , .. . _ _ _

-

il

LsUing by Geographic Areo and Granteo Instuliuon


FRANCEGIF SU8 YVETTE

Centre National de la Recherche ScientfáqueLederer, Edgar ....- . ... Chemical and biochemical research on bacterial

liplds.Institution total, 1 grant, $13,000

MARSEILLES

Feculty of Medicine-University of Alx-Marseille

Gastaut, Henii -.-..... Inteinational project on brain mechanisms in be-bavior.

Institution total, I grant, $13,800

PARIS

Claude Bernard Aoelation

Mlnkowski, A ..-.. . .Enzymes and electrolytes in oxygen affinity.Do ....-..... . .... Neurological examination of prematuue newborn-

Infants.Voisin, Guy A ...-..- Correlative study of homografts and autosensitiza-

tion.Institution total, 3 grants, $41,150

laboratoire de Recherche de Biologki Medeine Hopltai des Enfanlo-Malde

Dreyfus, Jean C ...- . Researchon thedynamicstateofproteins and cells._Scnapira, Georges ...-... Metabolic heterogeneity of hemoglobins ........


Hoepital Necker

Netter, Pierre A. -... European Cooperative Breast Cancer Group...Institution total, 1 grant, $6,300

Inatitut Natioral d'Hyglene

Noufflard, H..E.. ........ Drug-resistant tuberculous infections in children...Philippe, Laudat ..-.... Lipid metabolism in three endocrlnological diseases


Institut National de la Recherebe Agroninique

Busnel, Reneguy .-..... Biochemical brain changes induced by ataracticdrugs.


Naturalla and Biologla Sodety

Bessis, Marcel C ..- .... Differentiaton of normal and leukemic blood cells..Institution total, 1 grant, $9,757

Paris, UniversitJ of

Chany, Charles ...- . .... Studies on pre- and perinatal virus infections ......Dausset, Jean .....-... Surface leukocyte antigens and skin grafts.......Pullman, Bernard .----- Electronic molecular structure and cancer chemo-

therapy.Institution total, 3 grants, $44,287

Clinique de Genetique Medicale-University of Paris .

Lamy, Maurice ...-. . ... Etiologic studies on mental defidences ,........Institution total, 1 grant, $10,925

Plsern Ietateut

Orabar, Pierre .-... - Degradation of protein antigens in vrio and in vitro.Lacassagne, Antoine ----- Mechanism of carcinogenesis by conjugated mole-

cules.Laroche, Marie J -.... .Histamine In experimental tuberculosis ......Latarjet, Raymond ._.-- Viruses in leukemia ......... - - -Monod, Jacques -------. Biochemistry of gene control of protein synthesis...


E-2838C1.-... 26 $13,000

M-325SC1..... 23

B-2432C1 ..-. 41B-3130 -.. 7.... 7

E-3555 ....-... 13

G-6016C2..-.. .26A-2773C2..... 26

C-4894 -- - 12

E-3263C ..-.. - 24RF-16 ---- 58

M-2714CI .- 51

C-4664C1.... 6

E-2235C2 ..-. .7C-5573 ........ 13C-3073C4 ....- 1

M-3921C1 ... 29

E-3225C1...- 13C-524Cla3..-.. 97

RF-6 - --- 58C-5400..-.. - 25E- 3998-.. . .. 29

o

13,800

12,4005,750

23,000

10,00010,000

6,300

11, 1652,500

11,000

9,757

11,36728, 0104,910

10, 92

16, 2618,000

2,5005,000

69,240

e

·

4. Research Projeds Grants

Investigator Project titie Grant NQ. S.S. Dollars

FRANCE-Continued

PARIS-Continued

Laboratoire of EEG and Applied Neurophyaio-Salpetriere Hopital

Remiond, Antoine ..- . .. Human cranio-cerebral elec-topographical develop- B-1857C2 ... 3 $4,830ments.

Institution total, 1 grant, 54,S30

VILLEJUIP

. Institut de Reeherehes Scientifiques le Caneer-C.N.R.S.

Grabar, Pierre ..- . ...... Viruses in relation to malignancy .............-.. .C-4602C2 ...- -25 10, 700Institution total, 1 grant, $10,700

STATE TOTAL, 23 grants -.............. 339,669

GREECEATHENS

Athens, Universlty of

Fessas, Phaedon ....-.. The problem of hemoglobin H ..-..... - H--451C1 .... 6 5,000Institution total, 1 grant, $5.000

INDIVIDUAL GRANT

Papavassiliou, John ....- Importance of colicinogenic bacteria In feces ....- E -506--.. 24 600Institution total, 1 grant, $600

STATE TOTAL, 2 grants ..-........ 5,600

GUATEMALAGUATEMALA CITY

Institute of Nutrition of Central Amerm and Panam

De-La-Vega, Jose M .--. Xutrition research -..--.....-.-.-. .A-5582 ...- . . .34 53,646Institution total, 1 grant, $53,646

San Carlos University of Guatemala Cty

Aguilar, Francisco -.. . .Immunological tests or diagnosis of eystlcercosis .... E-3120C1 -...- 17 7,000Institution total, 1 grant, $7,000

STATE TOTAL, 2 grants -------..--.. ------------------------------------.--------------- 60, 646

HONG KONGHONG KONG

Hong Kong, University of

Barker, David . ------- A quantitative study of mammallan proprioceptors B-1806C2 .--- 9 8, 000Chang, K. 6S -. . ........ Growtbh anddevelopmentof Chinese in Hong Kong. 0-8387 - 3.... .38 16, 795


STATE TOTAL, 2 grants ..... ... ------------------------------------ 24,79

ICELANDREYKJAVIK

Institute of lxpermental Pathology-University of leelandSigurdsson, Bjorn ------. Visna--slow demyelinating leucoencepbalitis of B-2425 -.-- - 53' 10, 28

| I sheep.Institution Total, 1 grant, $10,528

1- 1 STATE TOTAL, 1 grant .....- ........ 10, M

Ie

Lisfing by Geographic Area and Grantee Instlftuion

Investigator Project title Grant No. S.S. Dollan

INDIA .

AGRA

Sarojini Naida Medical College

Wahi, P. N -.. . .._. .... Study of genital carcinoma in women of UttarPradesh.


ALIGARH

Allgarh Muslim Unnverslty

Khan, Nawab H .- . ...... Development and inheritance of resistance in .l1.nbialo.


BOMBAY

Nlneteenth International Congress of Ophtbalmology

Sen, Kiran ...-.. . ...... Nineteenth international congress of ophthalmologyInstitution total, I grant, $10,000

CALCUTTA

Indian Institute for Bioehemistry and Experlmienial Medicine

Pakrashi, Satyesh C ... · Hypotersive and tranquilzng alkalolds from indiaInstitution total, 1 grant, $10,I5

CHANDIGARH

Panjab Universty

Singh, Sheo D ..------ Effects of human contact on bebaviors of monkeys.Institution total, 1 grant, $3i200

DELHI

Vallabhbhai Patel Chest Institute-Universtty of Delhi

Venkltasubramanian, Carbohydrate metabollsm in tubereulosis.-....T.A.

lastitution total, 1 grant, $3,300

STATE TOTAL, 6 grants -...-.-.-. _..

C-9603C1 ..... 8

E-3946 .....-.. 17

B-2696 ..- . .... 53

H-4320C2 .- 14

M-5263 ....... 43

E-3427CI...... 33

IRELAND

DUBLIN

Medical Research Councdl of Ireland Labortarie

Barry, Vincent C .-.-- The mode of action of Isoniazid...... ....Do ..-... . ...... The tissue distribution of the rimino-compounds. _Do .....-. . ......... XNuelei acid metabollsm of Mycobacteria -.--.. ..

Conway, Edward J -..-. The redox pump in the active transport of ions ..Instltution total, 4 grants, 327,485

University College-National University of reland

Meenan, Patrick N -.... .A study of the natural history of influenza...-...Wheeler, Thomas S .-... Heterocyclic-favonoid types for anticancer testing..


E-2840C1 .-..E-2841C1 ......E-2842C1-.....H-n48~C1 ...

2424249

E-2733C1..... 25C-4759C1..-. 89

STATE TOTAL, 6 grants ..-...--- -45, 878

b j

i

1 _

-., _

iI'

-- i

no, 722

10,000

10,000

1.0, 925

2,300

3,300

- 47,247

4.0003.5004,000

15,985

3. 00

i 9

y*

4. Research Projects GraOm


ISRAEL

JERUSALEM

Hadaamah Medical Schol-Hebrew Unilty 'Enxymatic oxidation of purines and pteridines.....Immunological studies on trachoma virus.......Mechanism of Alpha-gamma shift in penicilinase..In vitro culture of &dstosoma maroanni........: .Immunological aspects of heart disease...........Bionomies of ticks ...........-- ------........Metabolism of the sphingollpids and C

sfatty acids.

Fluorine content in teeth and bones of Fetuses......Coronary disease related to diet and ways of llfe....Thyroid hormone action In hypothaslamus and

pitultary.Characterization and etiology of meat anemia in

mioe.Synthesis of cellulose and related polysaccharides..Immunological aspects of cornea] transplantationo..Bi mobilization and transport in experimental

anemia.Metabolism and transport of neutral fat.......... do ..................Resistance increasing activity of lipopolysaceha-

rides.Stein, Yehaeskel---------- Biosynthesis of IUpids in the aorta..~.. .s...

etinreb, Max M-------- Tooth development In sheep.............Zuckerman, Avivabh...- Study of autoantibody in malaria......... -


Hebrew UniverlyBloch-Frankenthal ,.-- Glucose metabolism in neoplastic celis ..........Kornblueth, Walter .-.- Carbohydrate metabolism of the lens.........Schramm, Michael ..-... Chemical mechanism of protein secretion by the cell.Shanan, Joel .-.. . .. Psychologicsl factos in funetional amenorrhea.....Shulor, Aharon M ...... Immunology of venoms of poisonous Israel animsals

Institution total, 5 gants, $48,.110

Israel Institute of Applied Sa] RsearchFoa, Urtel O ...-. . ...... Interpersonal factors tn marriage :......


NEZ ZIONA

rae l Insttutae for B~ Researeh

Avidor, Yoram ....----. Effect of carcinogenic agents on oxidative metabo-lism.

Tiett, Alisa ..-.... Fat metabolism in in-seets........... -Van der Hoeden, 1 ....-. Epidemlologlcal research on leptospirosis........

Institutlon total, 3 grants, $34,267

PETAH TIQVA

Hssharon HopttlMatoth, Yehuda s-S.. .... Studies on erythropoietinin itro ....... ...


Medical Rsearh Institute-BeUinsaon Hesplld

De Vrtes, Andre .-.... Epidemiology and etiology of trolithiasis In IsraelOitter, Simon .. _-.. Venoms of Near East snskea-propertlesand immu-

nology.Instituton total, 2 grants, 545,912

G-631C1 ......B-2824........E-3097CI _--E-3532 ....B-5739.....E-1006C3 .....B-2967 -----........D-1323 .-.....H-44~C1..I.G-7403C1-..

2251417131733

3818

A-436 85- . - 34

E-1494C4 -..-- 26B-20180C2 -.. _ 13H-5769 -. ...... 33

A-3038CI1 ....A-3038CIlS...E-3762.......

a83313

H-5705 -.. .... 33D-1319 ....... - 5E-2859C1 ..- .17

C-5271 --------...B-229sC1..-.-.E-342601C.....M-3498C1 -... .E-2960C1...

2262

2118

M-266902 --. 21

C-434402 ....- 2

0-8135---- 33E-3867-...--... 24

-493101 ...... 6

11, 21224,18011,27010,64417,0899,791

11,287

5 650

11, 500

15, 710

io0,oo0006,900

18,849

1s,o0s2,900

15,300

17,3222,3005, 760

11,4428,056

11,8008,1658,648

6,468

7,475

13,05013, 742

7,245

H-5774 -.-.... 22 17,652E-317101 ----- 8 28,260

Bergmann, Felix G...Bernkopf, H -.-.-.-Citri, N .................Clegg, John A -........Davles, Michael A ...-..Feldman-Muhsam, B..Gatt, Shimon ........-GOedalia, Itzhac-......Groen, Juda J.-.. ....Gross, Jack .-....

Guggenheim, Karl, .

Hestrin, Shlomo .-....Nelken, D..........Rachmllewitz, M ......

Sbapiro, Benyamin ...Sllo Meshe....-..._...

Shilo, Moshe

0

Lisling by Geographic Area and Grannt Insfitutlon


ISRAEL-ContinuedREHOVOTH

Weizmann Intitulte of Sli

Berenblum, Isaac ...e..Do ___--

Elson, David ...........Halmann, Martin M ..Katchalski, Ephraim....Latvie, David ...

Littauer, Uriel Z......Paeecht, Mella.......

Patchornik, Abraham_ _

Sachs, Leo.... -Sharon, Nathan......Traub, Wolfie... .....

Institution total, 12 1

iene

Biochemical studies on urethan carcinogenesis.....A possible two-stage mechanism in leukemogenesis._The latent enzymatic activity ofribonucleoproteins.Mechanism of bydrolysis of organie phosphates...Polyamino acids and their use as protein models....Antitumor compounds from Ecbalium and related

plants.Enzymatic ribopolynueleotide synthesis ....--.-.Deamination, polymerization of amino acid-phos-

pbates.Selective chemical cleavage of histidyl-peptide

bonds.In avtro analysis of mammalian tumor viruses..Studies of a diamino sugar from B. subtilis.....a....X-ray studies of polypeptides and nucleie acdds ...rants, $203,982

TEL AVIV

Government Hospital-Tel Aiv.iJaff

Brunner, Daniel .. . .Diet work and ethnic factors in vascular diseases...Institution total, 1 grant, $25,000

TEL HASHOMER

Government Ho~plalHeller, Harry .... . ... Studies on familal Mediterranean fever ......

Do ........... .. do _...... ...Lunenfeld, Bruno .... Clinical effects, purified human urinary gonadotro-

pinSzeinberg, Aryeh . ...... Hemolytic diseases peculiar to the Mediterranean

area.Institution total, 4 grants, $51,231

C-5263 ...-...C-5455 ......G-5876C2......G-58422.....A-3083C1....C-2810C4S1...-

268

26261

40

G-5217C2 .... 26G-7852 .---- 40

A-3171C1 -- 2

C-5266..-.. 25E-3528 ... . .... 2G-8608 .... . .. 1

H-4520C1.... 834

A-2857C2 .- 22A-2857C2S1 ... 22A--459C6. 18

A-2740C2 - - 6

STATE TOTAL, 49 grants ......-.-.-.- 687,699

ITALYBARI

Faculty of Medicine-Unlversity of 8ai

Fiore-Donati, L ....... _ Mast cell response in skin carcinogenesis of mouse_ .C-5439 ...... .8 5,250Institution total, 1 grant, $5,250

CAGLIARI

Cagliari, University of

Guido, Frizzi.. . ......... Population genetics and radiogenetics in mosquitoes. E-3795 ... . ... 17 15, 700Institution total, 1 grant, $15,700

FLORENCE

Florenee, Univesity of

Balduzzi, Piero ..... . Studies on normal inhibitors of .E. poigoma virus. C-5514 . . ...... 25Institution total, 1 grant, $4,700

4,700

GENOA

Faculty of Medieine and Surgery-University of GenoaBonsignore, Arturo.. .... Carbohydrate metabolism in red cells in human

favism.Salvidio, Emanuele .... S usceptiblity of Itallans to drug-indueed hemolysts.


e

IH-4586C1...... 6

H-5682 . ....-. 6

$23,00020,3509,660

13, 80025,0004,800

7,40024,033

7,475

32,7009,424

26,30

25,000

13,20016, 34111,690

10,000

10,000

15, 500

4. Research Projects Granft

Investigator Project titie Grant No. S.S. Dollars

ITALY-ConhinuedMILAN

Cancer Institute

Della-Porta, OG -.------- Intestinal and mammiary carcinogenesis In the ham-ster.


Milan, University ofAngostoni, Emilio. -. ... Thoraeo-abdominal mechaneis during PPB.....Polli, E. E-...... . ... The role of DNA in malignancy......- - -


0-5557 .....

RF-15, ---C-5544 _---_-

NAPLES

Anton and Reinhard Dohrn Foundation

Chieffi, Giovanni -.. . .Endocrinology of reproduction in elasmobrancbh G-6455Cfishes.

Dohrn, Peter ---.-.-.- Cell growth, division, metabolism, and related C-4402C4problems.

Ghiretti, Francesco ----- Metallo-proteins in marine invertebrates -.-.-.---- G-484504Scarano, Eduardo .---- Nucliel acids, cell multiplieation and development. C-5486 ...-.-.


Faculty of Medicine and Surgery-Unversity of NaplesGlordano, Carmelo .-..- A therapy of renal disease based on urea toxicity... H-5773 . .--.


Naples, University of

Nicolaus, Rodolfo A -- Structure of melanins and melanogenesis -...,... . C-5220 -.------Institution total, 1 grant, $14,700

PALERMO

Universita di Palenuo

Bonavita, Vincenzo -.. _ Evolution of dehydrogenases during neurogenesis__Monroy, Alberto ------- Study of mitochondria in the sea urchin egg -----.


PERUGIA

Faculty of Medidne and Surgery-Univeruiy of PerugLSeveri, Lucio ... . .._. .. A stady of mammary cancer ...........

Do ...-. . ................do .--. -.....-..-...-Institution total, 2 granta, $45,000

PISA

Pisa, Univeribty ofMoruzzi, Giuseppe .---- EEO synchronization and sleep --...... . .

Institution total, 1 grant, 25,010

ROME

Center Against Cardio Vascular Diseates and Rheumatic Fever of BomeFindanza, Flaminio. -... International research-Epidemiology of heart dis-

ease.Institution total, 1 grant, $6,000

Faculty of Medicine and Surgery-University of RomeQuintarelli, G _- Histochemical changes in the developing tooth-

germ.Do .-..... . Study of vascular tree of the periodontal membrane.

Institution total, 2 granta, $18,845

Instituto Regina Elena per Lo TumoriMargottini, Mario ...- European Cooperative Breast Cancer Group ._...


B-2917G-6211C2 :.....

C-3844CISI .. 8C-3844C2 ....- 8

B-2990 -..-. _ .3

H-4672CI 1.._ 34

D-1325 .....-. 5

D-1326 ........ 8

12 $12,100

58 2, 75025 50,000

18 9,720

27 10,000

2 11,00026 26,550

8 11, 017

2 14,700

26 9,14027 6,900

15,00030,000

25,010

6,000

4,755

14, 0i0

C-5006 ...-- 12 7,935

'TI i0

i

i1 .1

1

I

Listing by Geographic Area and Grantfe Institution


I T A LY-ContinuedTURIN

Institute of Oncology

Anglesio, Enrico ...-.. .. European Cooperative Breast Cancer Group .-. C-4895 ... 12 $7, 705Institution total, 1 grant, $S7,5

STATE TOTAL, 24 grants ..-............. 3235,522

JAMAICAMONA

West Indies University, College of the

Bras, Qerrit -..... .. Aetiology of veno-oeclusive disease of the liver ...- A-4525 ....- 8 10, 520Institutional total, 1 grant, $10,520

STATE TOTAL, 1 grant ..-.......... ..............--- 10,520

JAPANFUKUOKA

Kyushu University

Ueki, Showa -........ Effects ot drugs on the limbic system......;....Institution total, 1 grant, $2,300

KANAZAWA

Nara Medical College

Yasuzumi, O -.-. . .. Electron microscopy of nutritive celis and sperma-tlds.


KURUME CITY

Faculty of Medicine-Kurume Universlt

N-ishi, Syogoro .-...- Injection of ions into single ganglion cells ........Institution total, 1 grant, $4,099

KYOTO

Kyoto Prefectural University of MedicineYonezawa, Takeshi --- .lyelinating process In nerve tissue culture .....


Kyoto Unhlersity

Hayaishi, Osamu..-..-.- Studies on oxygenases --.----------- ...----.....Do -......... do .-.........


MISIMA

National Institute of Genetics

lino, Tetsuo ..-....... Immunogenetics of Salmonella .............Oshima, Chozo .-.... . Study of deleterious genes in Droaopila populations.


M-4476A .----- 60

0-8327 .----- 27

B-3141.-..... .9-

B-3173 ----- 8

C-4222C281 . 26C-422C3 ...- 26

E-2872C1-. . ... 29G-78, .36-.. . .. 29

NAGOYA

Nagoya UniveraltyHirata, Yoshimasa Organic he micai studies oi animal and plant toxin 0-7969 --...- 40Oosawa, Fumio .-..-. . .Physical cbemistry of actin ..-............. A-4534 .......- 1


2,300

7,400

4,099

23, 69

13,00010,000

4,7009,300

9 70023,58s

4. Research Projedf Gronfs


JAPAN-Confinued

OSARÁ

Faeulty of Medicine-Osaka Univeraity

Donomae, Imasato ...-- Epidemiology and patbology of arterloselerosis-Japan.

Kawamata, Junichi -.. Studies on experimental chemotberapy of cancer...Institution total, 2.grants, $26,000

Faculty of Pharmacy-Osaka UniverstyHano, Kotobuki -. . ....- Anticancer testing of the Far Eastern plant prod-

uets.Institution total, 1 grant, $13,340

Oseka UniversibKurahashi, Kiyoshi- . . .. Studies on enzymes of galactose metabolismr.......Miyaji, Toru .---------- Hepatoma and cirrhosis in Japan............ -Nomura, Masayasu ...- Role of ribonueleic acid In phage multiplication ...-Okunuki, Kazuo -.... . Crystalline cytochrome C from various sources ..-.


Polytechnic Institute, Osaka City Univeraty

Matsuura, Teruo -. .M... Model reactions for the biosynthesis of th5yrosine-.-Institution total, 1 grant, $8,682

SAPPORO

Research Institute for Catalysis Hokkaido University

Tonomura, Yuji ..-.. . .Molecular mechanism of muscle contraction ......---Institution total, 1 grant, $10,095

SENDAI

Tohoku University

Segi, Mfitsuo --.. -------- Statistical studyofCancer morbidity in Miyagi Pre-fecture.


TOKYO

Cuaner Institute

Naora, Hiroto--..-..E. . Studies on physiology of cancer cell-.........Institution total, 1 grant, $15,807

Central Laboratories for Experimental AnhulsAndo, KoJi ...-..... Supply of mice and pellets for cancer research ..-..


Faeulty of Agrieulture-Univeralbty of TokyoAruga, Hisao -....... ... Induction and interference of vires in insets.....Kono, Tetsuro ...- . ... Properties of isolated musele cell membrane .....


Faculty of Medicine-Keio UnlversitySaito, Shoji -... G... . Gaba, acetylchlorine, and brain function........


Faculty of Selenee-Univerlty of TokyoTerayama, Biroshi ----- Interaction between carcinogen and cellular com-

ponent.Institution total, 1 grant, $7,245

Institute of Applied Microbiology-University of TokyoUmezawa, Hamao ..-. Studies on antitumor antibiotics --....-.-.-. ..


H-4402C1.-... 8

C-5075 .....-.. 12

C-5257 ---- 12

A-4600.........C-3481C3 ..-E-3809 ......G-5871C2 ....-

28

2326

A-3705C1 .--- 18

A-4233 ..-... 1

C-9618C2 ..... 38

C-5275 -_--- 27

C-5089 ...-.... 29

E-3967 ......- - 17A-5006 -..... 26

B-3181 ........ 14

C-5246 ...-.... 12

C-5082 ...... 12 .40,400

.

$10,000

16.000

13, 340

- 24.2904.000

61, 85I2. 898

8, 682

10,095

15.000

15, 807

67, 480

8, 55010,003

2,044

7,245

Listing by Geographic Area ond Grantee Institfuion

Investigator Projecttitle Grant Nq. S.S. Dollars

JAPAN-Coninued .

TOKYO-Continued

Institute of Publie HealthOshima, Tomoo ...-... .. Larval nematodiases in Japan....-..........-..


Japanese Association of Medical Siences

Okinaka, Shigeo -.. . Epidemiologic survey of selected neurologie dis-orders.


Kitasto Institute for Infectionu Disease

Hata, Toju .------------ Isolation and screening of anticancer antibiotics....Institution total, 1 grant, $35,862

Medical Institute of Sasaki Foundation

Yoshida, Tomizo ...-.. Ascites tumor system for chemotherapy screening..Institution total, 1 grant, $9,500

National Institute of Health

Ishizaka, Kimishige ...... Immune mechanism of hypersensitivity.......Tagaya, Isamu ........- Studies on a mutant of dermovaccinia virus.....

Institution total, 2 grants, S8,223

Nihon Kiseichu Jobokli

Sasa, Manabu .------... Experimental studies on filarlasis control ......-Institution total, 1 grant, $15,000

Showa Medical College

Sugiura, Saburo ......-.. Studies on schistosomiasls .-...... - -Institution total, 1 grant, $5,750

Taksass Clinie, Utniversly of Tokyo School of Medicine

Tasaka, Dadstada -..--- Early diagnoais ofstomach cancer by gastrocamera..Institution total, 1 grant, $10,000

Tokugawa Institute for Biologkcl semrch

Iwamura, Tatsuichii ...- Nucleic acids and their metabolism in ChioreUa..Institution total, 1 grant, $23,690

Tokyo Mledical and Dental UMsraltyKatsuki, Yasuji---------- Dip cone technlic and nerve eelIs ........ ..Shimamoto, Takio ...-. Arteriosclerosis under low fat diet .......-


Tokyo, Unlversity of

Ebashi, Setsuro .-------- ATP-linked calcium binding of sarcoplasmlc reticu-lum.

Kobayashi, Hideshi ..-.. Biochomical research on neurosecretion ...........Institution total, 2 grants, $15,550

TSU

MIE Prefectural Uaiversity

gosaki, Takekazu .-.-- Studies on malignolipin, a phospholipidofcancers-.Institution total, 1 grant, $11,500

YOKOHAMA

Yokohama City Univeesiy

Yoshino, Kamesaburo.-- Herpes virus infection of the egg chorioallantois....Do .-..... . .Production of rabies vaccine with one-day eggs.....


RF-9 - .- S..... ,8

B-238C2 --.. 41

C-5085--.... ... 12

C-2799C5..--... 12

E-3308C1 ...... 13E-39709.--..-. 25

E-3328R1....- 17

E-2459C2 .-. . 17

C-9772......

0-7601 .-.... . 2V7

B-2697 9....._. 9H-5196R1 .--- 34

A-4810 ---- 1

A-36780CI1.... 19

C-4795C1....- 12

E-4247 .-. .... 25E-4248...-. .. 25

STATE TOTAL, 44 grants .-...... 6o..17, 624

e

$2 875

7,190

35 862

9, 500

3,0005,223

15,090

5,750

10.000

23,690

10, 00027,383

8, 520

7,027

11, 500

3,5836, 49

? T

4. Research Project Grantm

Investigator Project title - Grant No. S.S. Dollars

KOREASEOUL

Seoul National Universlty

Kim, Jae N .-.... Diabetes and pregnancy .....................- ... A-3764C1 .... 3 $8, 788Institution total, 1 grant, 8,788

Yonsei University Seool of MedicineLee, Woo C......- - A signifieance of myocardial catecholamines .-.. -11-5264C...-. 14 5,405Osborn, John J .-.... .Circulatory physiology after cardiac defect closure. H11-5265S1------- 19 15,525

Institution total, 2 grants, 20~,930

STATE TOTAL, 3 grants .--- ......------------ ..........------ ------ - 29,718

LEBANONBEIRUT

American Uníversity of Beirut

Al-Khalidi, Usama ---- G(uanine metabolism in Erymothestum ashbby 11 ... E-3773 .......- 2 15, 554Cowan, James W ------- Nutritive value of Middle Eastern foods ....-.-.. A-4562 ....... 34 12,052Farah, Fuad S .-.. . .... Allergicskin reactions of wbeai and erythema type.. E-2910C1 ...... 13 9,200Garabedian, Garabed.-.. Laboratorystudies oasepticmeningitisinLebanon. E-3812 .....-.. 25 11,850Ilanania, George I ----- Heme-linked effects In hemoglobin reactions -........ -4994C1... 1 7,8llarfouche, Jamal K .--- Calorie and protein malnutrition in Lebanese in- A-4574 -....... 34 29,693

ants.Khachadurian, A. K M..... etabolism ofadipose tisue in the fat tal sheep .. .A-42,0 ........ 33 7,541Schawabe, Calvin W.-.. Host-parasite relationships in echinococcosis .-... E-2205C3 ....- 17 13, 800Shahid, Munib-. . -.. . .Hemoglobinopathies in the Middle East ...-...... 0-8607 ...-. . .6 8,050Shanklin, William --... A histological study of neurosecretion in man -.... .-B-1701C3 27 4, 473Wilson, John L ...... Cardiovascular disease in the Mlddle East -.. H-3671C2 ...... 19 5,865Woodruff, Calvin W... Etiologie factors in hypochromic anemia -.-....- .. A-4509C1 .. .- 7 9,645


STATE TOTAL, 12 gran ..ts- ............ . 135,543

MEXICO

MEXICO, D. F.

Escuela Nacional de Ciencias Biologicas -Instituto Politecnlo Ncbioal

Hecht, Otto .-.. . .Repellency of insecticides and other substances .... E-3116CI .-... 17 7,100Institution total, 1 grant, $7,100

Escuela Nacional de Odontologba-Unhversity of Mexilo r

Hixon, Ernest H -....... Oral function and dentofadcal dimensions ...-... D-1361 ........ 5 5,475Institution total, 1 grant, $5,475

Hospital Infantil

Gomez, S. Federico .-.-- Infantile protein malnutrition .-.....-.-.- A-1520C3 .. 3 25,000Kumate-Rodriguez, J .... Metabolbsm of Salmonella tlphoa antigens ...---.. E--042... l3 14,945Ramos-Alvarez, M .-. Viral and bacterial studies of infectious diarrhea.... E-3162C1 ... 24 34, 650


Instituto Nacional de la NUltrjon

Gual, Carlos .-..... Biosynthesis of sterold hormones in abnormal tis- C-4639C1 .... 13,800snes.

Institution total, 1 grant, $13,8/0

Mexico, University ofDel Rio-Estrada ....-. The blosynthesisofnicotlnic a aid by ,ltcobactria.. E-3815 .. 2 1, 78Ramirez, Bernardo .-... Bat migrationandrelation to rabies disseminatlon.. E-380 ..... 17 27


ve

4

-i

Lising by Geogrophic Areo and GrannIt Institutio


MEXICO-ContinuedMEXICO, D. F.-Contfined

Unit of Patholoey-University of MexicoBiagi, Francisco F ...-.. Pathogenleity andserology ofE. Ehistolyioa......- E-3129C1 ...- 17 $6,900


MOREUA

Universidad Michoacana de San Nicolas de Hidalgo.Alvizouri, Mario .------- Experimental cervical cancer-hormonal nfluences. C-50240C1- . - 8 2, 520


STATE TOTAL, 10 grants -- ...----------------------------..------------------------ 18,43

NETHERLANDS

AERDENHOUT

Federation Dentaire InternUionalePedersen. P. O --------- Dental lexicon in five languages .-.........- D-1447 .... 96_ 4,025Stones, H. H .....- . Transactions 13th nternatUonal dental congress ..- D-1448 .. 96 10, 143


AMSTERDAM

Blood Transtusion Central Laboratory-Netheriands Red CrossPondman, K. W ...-... S. Substances of immunological importance in human E-3951- ....... 13

milk.Institution total, 1 grant, $15,460

Central Institute for Brain ReaeMhSchade, Johannes P- .Surface area and patterns of cortiecal neuronsa..-.. .B-3048 ....-.. . 9


Excerpta Medica FoundationWoerdeman, MI. W -.. . .Continuation of the cancer section of Excerpta C-9346C7 .-.. S96

Medica.Do ...-... - To publish translations of Japanese medical ab- G-7410C1 ..... 96

stracts.Do .....-........ Medical abstract ln human developmental blojogy G-7735 -...... .

field.Do .--.--.-.. ' Publication of Cardiovascular Abstractlng Journal. E-289SC4-..... 97Do-.....'.... Publication of Oerontology Abstracting Journal -... -3621C3 ..-.- 97Do .- ......- .do... ..............-.- : M-2373C3 .... 97


Laboratory of Physlologlcal Chemistry-Universlty of AmsterdamSlater, Edward C ...- Respiratory inhibitors and uncoupling agents ....- G-~569C1 .....- 14


Netherlanda Cancer InstituteMnuhlbock, O ......-. Hormonal genesis ol mammary cancer .-... . ..... C-3431C3..... 27

Institution total, 1 grant, *26,700

LEIDEN

Leiden, Unlversity ofBottcher, C. J --...... ... Atheroselerosis and thrombosis lipid investigatlons 1 H-5766 -... . . ..33


NYMEGEN

Roomsch Katholleke UnlraiteitZllliken, F. W, ..-.. . Novel amino sugars from bacteria..-............ E-3987 ...... 2


15, 460

4, 750

4,790

90 850

28,750

14, 9508,6258,625

6,647

26,700

24,000

15,000

i1l

.

4. Resoc Poj~tac Granft

lnvestigato~ Project title Grant No. S.S. Dollars

NETHERLANDS-ContinuedROTTERDAM

Rotterd RMdio Tberapeutisch InstituutVan Oilse., . A ......... European Cooperative Breast Cancer Group....... C-5185 ....... 56

Insttulion total, 1 grant, $3,100

THE HAGUE

Netherlands Nutrition Coundl

Van Buchem. Frans-.... A eld survey on coronary heart diseasease..-..... H-5471-...... 15Institution total, 1 grant, $6,260

STATE TOTAL, 16 grants ..........................- --

$3,100

6,260

272,675

NEW CALEDONIA

NOUMEA

South PaCei C.mimsion

Smith, T. R .---..-. .... Urbanization Advisory Commirttee meeting .-. .... 0-8236-96 6 6.9296Instit~in total, I grant, $6,920

STATe TOTAL, 1 grant -,920.......................- ....---- 7-----------,---

NEW -ZEALANDCHRISTCHUIICH

North Can utry Hospit BoardOunz, Fredeh W..... Incidence and etiology of leukema in New Zealand. C-3707C3 - 6--. 6

Institutil total, 1 grant, $5,600

DUNEDIN

Ofo. Uldeui_~ ofLudwig, T. O ...-. . .New Zcaland dental caries and -oil relationsbip-... D-5C1 ...... 5Shaw, Dcmts R ..... Bacterial polymer synthesis and polol metabolism. E-3548. ..- . ... 26

Instituotl~ total, 2 grants, $12,588

STATE TOTAL, 3 grants..

5,600

8.6703,918

18, 188

NORWAYOSLO

Anatomil lelitute--Olo UniveruityBlackstad, 'Todr ...... Electron microscopy of central nervous system ..--

Institui~on total, 1 grant, $6,600

Institute far S~ Research

Aubert, Vilelm ...... study of isolated familfes and communitles.....Institultan total, 1 grant, $13,22S

Institute of H_~*n Genetica-Oalo University

Molir, Jan ...-.... . Linkage and mutation in man. ._...Instítuon total, 1 grant, $9.775

Norsk Hydwiahetitute for Caneer Reaoerch

Pihl, Alexand-er .... - Enzymatic and EPR studies of radiation damage..Institllo total, 1 grant, $18,745

B-2215C1 .---- 27

M-4547 ..-... 23

G--6842C1 .... 29

A-4278 .....- .. 31

V

;r "I4,i

6,600

13,225

9,775

18,745

Listing by Geogrophic Area and Granltee Institufion


NORWAY-Continued

OSLO-Continued

Norwegian Institute of Dental Research

Mlorch, Tormod.- ...... Experiments on changes in topically treated en-amel.


Surgical Department A of the Univerlty epHoital

Efskind, Leif -........... Detection and culture of tumor cells in lymph andblood.


D-901C2...... 5 $12,401

C-e653C1- .. 66

STATE TOTAL, 11 giants5....a................

10,000

: 70,746

PAKISTAN

DACCA

Dasea Unversity

Ahmad, Kamaluddino.. Antibioticsand plant medicinals of Pakistan..... E-3913 . 40 24,000Institution total, 1 grant, S24,000

STATE TOTAL, 1 grant -.........- ----....--.. ----------------..------------------- 24,000

PERU

LiMA

·Brain Research Center, Peruvian Armed Forces.

Alzamora-Castro, V -..- Cardiovascular studies at high altitude..... .---Institution total, I grant, $24,867

Universidad Nacional Mayor De San MAroArias-Steila, Javie ..-... .Infant hearts and pulmonary vessels at high altitude.Garda-Caceres, U __-.- Tubular alterations In glomerulonepbritits_ .......Hurtado, Alberto .....- Tberapy of Pseudomonas infections......-......

Do........... ... .--- do ..Do .........-...... Process of aging at sea level and at high altitudes. --

Morichaves, Pablo ....-. The effect of high altítude on neoplastic growth....Institution total, 6 grants, $205,677

H-6740 ---- 4

H--4787C1-..... 8H-5692 -... 80-3123C10-.... 19G-3123C10S... 190-8576 .------- 96C-3338C3 -.. .8

STATE TOTAL, 7grants .-.................. 230.544

PHILIPPINES

QUEZON CITY

Philippines, Univeriaty of TheVelasquez, Carmen C.. ParasitesofPhilippine ood fishes ....-......---- E-2b75C2 ...-.. 17 575Yogore, M. 0. Jr ....- . .ImmunologyandserologyoISchistosomiasisjaponica. RF-19 .... 58 2,75


STATE TOTAL, 2grants ........-............. 34.50

PORTUGAL

119BON

Faculty of Medicine-Univeriaty of Libon

Horta, Jorge .-..-... .. Research on the effect of thorotrast ......-..-.. C-4864C1-- 8 12,283Janz, Guilherme J_-.. .Cancer rates survey in Luanda, Angola .. C-533115 .... 5,100


24,867

13, 60014,20028,0788,830

122,i0o18,009

.' l

' '-.k

4. Research Projects Granft


PORTUGAL-Continued

OPORTO

Faculdade de Farnmaia-Universidade do Porto

Guerra, Francisco ....... Swellog and membranes-hrain and liver mito- G-8138- ...... 26 $12.995chondria.


STATE TOTAL, 3 grants_ .-....... -..--- 50,378

REPUBLIC OF CONGO (LEOPOLDVILLE)BUKAVU

Institut Pour la Recherche Scientihque en Aflique CentraleDemaeyer, Edouard-._.. .Malnutrition in African chlldren._-_....... . .A-3617C1...... 34,

Institution total, 1 grant. $13,80013,800

STANLEYVILLE

Laboratoire Medical Provinchal

Courtois, Ohislain_ ..- Capturcand eamp fore.pperlmentsonchlmpanzees.. H-5207 -...... 82 27 951Institution total, 1 grant, $27,951.

STATE TOTAL, 2 grants .-.a.. ........................... - 41, 751

REPUBLIC OF SOUTH AFRICACAPETOWN

Cape Town, University of

Brock, John F -...... Protein malnutrition, kwashiorkor, and amino aclds.Bronte-Stewart, B .----- Dietary fat, serum cholesterol and heart disease....

Do .-........-.. . ...- do.............Polson, A ..-........ .Structure of African and other viruses.........

Instftution total, 4 grants, $101,923

DURBAN

Natal Univerait

Hathorn, M. K Human and experimental nutritional siderosis .....Wainwright, John --.... Atherosclerosis in certain races..-..........-

Institution total, ? grants, $13,080

JOHANNESBUIIG

South African Institute foer Medical ResearchBernstein, Ralph E ...... Red celi metabolie detects in drug-dietary anemias..Walker, Alexander R ..- Studies on coronary artery disease among the Bantu.


Witwatereand. Univerilty of

Bothwell, Thomas H -... Iron overload In the Bantu_ ...... ..............Getz, Godfrey S -------- Funetion and biosynthesis of unsaturated fatty

acidas.Institution total, 2 grants, $18,225

PRETORIA

South African Council for Sdentific and Industrial esearchElsdondew, R .......-. Factors determining invasiveness in E. hstolytica..

Institution total, 1 grant, S25,000

A-3995CI ----H-3316C3-...H-3316C3S ...E-4044.

34343425

A-3532C1I--.. 34H-5445 -... S....8

H-5448 .-.-_. .34H-244C1-_... .97

A-4912 .-...... 6A-39911I - 33

E-1592C4 -- 17

STATE TOTAL, 11 grants .8.. ............... - -, 8GS

>

28,75028,7505,175

39,248

8,2504,830

7, 302,2S0

15, 0003, 225

26,iO

0

Listing by Geographic Areo and Grante. Institution

Investigator Project titie Grant No. S.S. Dolloe

SPAINGRANADA

Faculty of Medicine-University of Granada

Reinoso-Suarez, F ....... Brachium-conjunctivum .pontisoralisand EEGO B-3208 ...... 3 S3,800Institution total, 1 grant, $3,800

MADRID

Instituto Gregorio Maranon

Sols, Alberto .........- . Early steps of glycolysis .. _.... ---. .......-. -8041. ..... 2 15, 100Institution total, 1 grant, $15,100

STATE TOTAL, 2 grants .- ........ ........ .........- ...... 18,900

SWEDENGOTHENBURG

Faculty of Medicine-University of Gothenburg

Abrahamsson, Sixten .... Molecular arrangement in complex liplds. .......Folkow, Bjorn U .....- . Neurohormonal control of the vascular bed.......

Do ..........-..... .. do . ...................Institution total, 3 grants, $37.291

Gothenburg, University of

Branemark, P .......... Studies in bone marrow funetion............Engstrom, Hans ..... Eflect o high-intensity nolse on inner ear........Lindell, Sven-Eric ..-. .Hilstamine metabolism in man .......... -Zetterstrom, Rolf ......- Acceptor RNA and Its role in protein synthesis ..-


LUND

Institute of Physiology-Univeraity of Lud

Kahison, George S - l..... istamine formation n- foetal and regenerativegrowth.

Instltution total, 1 grant, $6,000

Lund, Univeraity of

Bauer, Goran C ....-.. .Calcium kineties in metabollc bone disease ......Blomstrand, Rolf L.-. .. Study on lipid metabolism related to atberoscleroslisBorgstrom, Bengt .....- Metabolism of exogeneous and endogeneous lipids..Hillarp; Nils-Ake........ Mechanisms of storage and release of cateeholamines.Liden, Kurt V -..... Whole body counting of radioactivity in humans...Thesleff, Stephen W ----- Innervation and the chemical sensitivity of muscle.


STOCKHOLM

lmmunological Research Laboratory

Biorklund, Knut B -... .lm mune lysis of human cancer cells ...-.-.-.. ..Institution total, 1 grant, $38,300

Institute of Pathology-Karoinska Institutet

Rtngertz, Nils O........ Study on polyoma virus tumors...........Institution total, 1 grant, $20,000

Isotope Laboratory of Cardiovascular Cline, South Hospital

Nylin, Gustave -...... Studies on cerebral blood flow with labeled red cells.Institution total, 1 grant, $27.149

A-4006CI.... 1 27,F21H-/ 67A---. 9 - 9,000H-567b81 ... -- 9 470

H-5724 .......B-2878 ......E-3379CI -A-3989CI.. -

630227

H-4961C1.....- 7

D-1452 -----H-5902.. .....H-53( ...-....B-2854.....C-5515 ....6..B-2646 ._....

333333273114

C-4587C1-..... 25

C-4846 ........ 25

H-3219C2 ..... 9

25,87810, 00010,7009,085

0,000

25, 5009,132

61,55010,00028, 02013, 00

8,MO

20.000

27, 149

-f .

»: 1

í

4. Research Projectr Granft


SWEDEN-Confinued

STOCKHOLM-Continued

Karolinska Institutet

Bellman, Sven E ....Bergstrom, Sune ...-....Caspersson, Torbjor ..

Do..................Diczfalusy, E -..-..Engstrom, Arne.........Gustafsson, BengtE .-- _

Do .-.........Heden, Carl-Goran .----Jacobson, Bertil --------Jorpes, J. E...........Klein, Georg .......

Do ..................Malmgren, Berndt ....

Do ...-.-............Reichard, Peter ---------

Thorsen, H. -.....Uvnas, Borje ...........

Deteriorative and regenerative vascular responses_.Metabolism of steroids and bile acids ..-..-... _..Quantitative cytochemical studies of cell growth -..Quantitative cytoehemical studies of the cell ......Studies on the endocrinology of the placental barrier.Biophysical studies of bone and teeth....... ..Rearing of a colony of germfree rats ....... ...... do .-.......- -------- --....-.. . .........Pressure effects on nuclelc acids in vivo and in vitro.-_Development and use of endoradiosonde technics_-.Blood clotting factors......... - ---Cytogenetics of variability in cancer cell populatlons_Viral tumorigenesis and cellular phenotype ....Studies on pollen from ragweed .............

Pyrimidine synthesis In normal and neoplastictissues.

Stabilizers for erythrocyte suspension -------------Physiological and pharmacological study---circula-

tion.Do -..-. . ......... Studies of acid lipid substance, SRS, in mast cells__

WYestin, Bjorn E ...- . ... Measurements of human ovarian blood flow ......Institution total, 20 grants, $477,165

Konung Gustaf V's Foesknigsinmstitut

Gemzell, Carl A -.. . .... Purification of human growth hormone............Institution total, 1 grant, $13,080

Stockholm. Univety of

Akerfeldt, Stig 0 ------- Biological significance of S-phosphorylated thiols_..Bostrom, Harry_ -. . ... Studies on ester sulfate compounds in tissues.....-.

Do -.---------------- Excretion of sulfate acceptors in metabolic disorders.Hultin, Tore ...-. . .... Protein metabolism and tumor induction ... ..

Institutional total, 4 grants, $66,695

UPPSALA

Uppsala, University toBarany, Ernst H .-. . ... Physiology and pharmacology of ocular pressure ...Boman, Hans OG .------ Enzymic structure analysis of transfer RNA ------Fredga, .Ane ..-. . ..... Synthesis of factor 3-like selenium compounds .....Fries, Nils .------------- Growth studies in the thallotron .........-Malmstrom, Bo O . .-... Structure and activity of metal enzymes.........Obrink, Karl J .--------- Ion movements in beating hearts .-....-. ..


INDIVIDUAL GRANT

Lundegardh, H. 0 ------ Salt effect on respiration _....... . ......Do _---- . .. .......do --.....


H-4865 --------.H-2842C4 .....C-4716C1...C-3082C4 -....A-277101-I -D-700C3 ...A-1933C3 -..-A-1933C381C-5799 .....A-2338C2 ....H-4295CI1 ...C-3700C3 -.---C-4747C2 ......E-2903C1 .....E-2903C181...0-4619C1I_-...

27

1

343425226

2925131326

H-4909 ---- 6H--6633 .. --- 9

A-063C1-.... 14RF-14 - . .- 58

A-2156C2 --- 18

0-8206....A-25~8C2. .-A-4410 ----C-5278 ---..

B-3060. ----...G-7576 ---A-4317 ------..0-8157 -......G-6542C1 -----.H-5346 --

2333327

302

142729

0-7737 -.. . 27G-7737S1 -- - 27

STATE TOTAL, 50 grants .. 1.,01.1....

.

$17, 72155,00050,00030,000

9,1896 0009,000

68,07847, 28911, 50014, 70020,00036,00012,0003,4858,625

25,91726, 586

23,5752,500

13,080

8,24511,50019,25027,700

33,33014,0007,070

32,8004,6005,750

9, 75015, 000

11

1,011, 445

,t ' 9

' -, 1

.

lsting by Geographic Area and Gronlee Instlituton


SWITZERLAND

BERN

Bern, University of

De Weck, Alain L -... ... Studies on penicillin hypersensitivity ...........Fankhauser, Rudolph... A study of spontaneous nervous disease in animals__

Institution total, 2 grants, $7, 100

GENEVA

World Health Organization

Candau, Marcolino O.... Bilharziasis research........... - -Do- ....... . Insecticide resistance and vector control.......


LAUSANNE

Institut d Anathomlc PathologiqueRabinowicz, T -..-... . .Prenatal development of the buman cerebral cortex.


Lausanne, Universlty ofFleisch, Herbert A ...... Activation and Inhibition In calcificationL.... -


ZURICH

Swiss Federal Institute of TechbnologyKeller, Roberts ..-. . .... Basic mechanisms of shock propagation ...........


Universilty Hospital-University of ZurichMartz, George ..-. . ..... European Cooperative Breast Cancer Group..---


RF-5 .....-... 58B-1916C2 ...... 3

E-3717 .-...... 17G-7542 --- - 35

M-156IC3 ...- .8

A-49009.....- 22

E-2855RI .-... 13

C-4892 ......- . 12

STATE TOTAL, 8 grants -............. . , 3289970

TANGANYIKA

MWANZA

East African Institute for Medical ResearehMIcLaren, Donald S .... Nutritional ophthalmology research in East Africa. B-2190CI ..... 34 24,035


STATE TOTAL, 1 grant -...... - - _ 24,035

THAILAND

-BANGKOK

University of Medical SdelnceBhamarapravati, N ..-... Application of fluorescentantibody totissue ection. E-3974 ... . 25 S, 900Buri, Rachit .----------- Hemodialysis in treatment of acute glomerulone- RF-11-..... 58 2,00

phritis.Piyaratn, Prapont .....- Tbe pathology of Bangkok epidemic hemorrhagic E-2890C1 _ 25 7,245

fever.Institution total, 3 grants, $15,645STATE TOTAL, 3 grants ...-- -------------------------------------------------------- 15, 645

O

S2,6004,500

78 940204,000

12,650

11,000

8,000

4. Research Projecs Grants

Investigator Project title Grant No. S.S. DollarsGato. $S olr

TURKEYANKARA

Research Institute of Child Health

Dogramaci, Ihsan A ..-. Study of toxic cutaneous porphyria In Turkey ---- A-4436 .. 6 14, 350Institution total, 1 grant, $14,350

STATE TOTAL, 1 grant-----....- ....------------------------------------------ 14,350

UNITED KINGDOMABERDEEN

Marischal College-Universlty of Aberdeen

Kosterlitz, Hans W -... - Mechanism of action of morphloe and other anal-gesics.

Simkin, Julius L, ------- Biosynthesis of soluble proteins by microsomes.....Institution total, 2 grants, $24,421

BIRMINGHAM

I ~~~~~~~Birmingham Universlty

.~j Frazer, Alastair C ..-... Pathogenefic factors In rmalabsorption syndromes.Do ..-........ . Studles on the biological effects of food additives....Do ......-......... do.......................

Watts, George T .-... .Collagen and mucopolysaccharides in healingwounds.

- _ Institution total, 4 grants, $100,178

CAMBRIDGE

Cambridge University

? 'r ~ Coomhbs, Robin R..... OGeneral immunological studies........ -Cross, Barry A ......... Cell activity In the hypothalamo-hypophyslal com-

* ,plex.

Rushton, William A .-..- The nature of tbe visual process In the retina .......- i Institution total, 3 grants, S33,837

Virus Research Unit-Agricultural .Research Coundil

M- arkham. Roy .-------- Virus and nucleie acid structure............. ..Institution total, 1 grant, $25,150

CARDIFF

University College of South Wales and Menmouthshlre-Universlty of Wales

Dodgson, K. cS -. ..... Metabolism ofsulphated mucopolysacoharides ....Institution total, 1 grant, $4,584

EDINBURGH

Edinburgh University

Gardner, Duga3d L-.. .The pathogenesis of hypersenstive vascular disease.Institution total, 1 grant, $14,881

Institute of Animal Genetics-University of Edinburgh

Auerbach, Charlotte ..-. Action of chemical mutagens on micro-organisms-..Institution total, 1 grant, $7,000

GLASGOW

Glasgow, UnIersity of

'¡ Pontecorvo, Guido... Genetic analysis of man based on mitotie segrega-tion.


:I

7S

B-3026 ..-. .... 14

A-4346- ..-. _.. 26

A-4737 -- -G-6732C1 ....G-6732CIS1-1.-.H-5772 ....

34353519

E-3348C1 ..-. 13B-2958 .-...-.- 9

B-3014 -...... 30

E-3400C1I..- 2

A-198202 _..-. 26

H-5173 -... 8

0-62302 ..... 29

0-580C2 -.-.- 29

11, 421

lS,000

5, 29027, 320S,1188,450

7,93715,000

10,900

28,150

4584

14,8SI

7,000

27,000

Lisling by Geographic Area and GrOante Institution


UNITED KINGDOM-Continued

LEEDS

Leeds, University ofAstbury, William T .... Structure of biological macromolecules and tissues..Pautard, Frederick ..... Studies of biological calclfication..............


LIVERPOOL

Liverpool School of Tropical Medicine

Augustin, Rosa .-.. . .. Allergy versus antigens-isolation and standardiza-tion.


Liverpool, University ofGregory, Roderio A ..... Gastric seeretory stimulation and Inhibition.......


LONDON

Birkbeck College-University of LondonKlug, Aaron ............ Molecular structure of viruses..........


British MuseumWright, Christopher-.... Intermediate host-parasitic relations in Sdchstasoma_

Institution total, 1 grant, 22,000.

Charing Cross Hospital Medical Sebool-University of London

De Wardener, H ...-.... Control of urinary salt excretions .... .......Institution total, 1 grant, $11,210

Chester Beatty Research InstituteHaddow, Alexander-.. Cancer chemotherapy and carcinogenesis...........


Guys Hospital Medical School-Unlversity of LondonHaslewood, Geoffrey ...- A study of vertebrate bile salts .............


London Hospital Medical College and Dental School-University of LondonCarbonell, Virginia ..... Dentition of early British skulls, 00-1800 A.D.....


London School of Hygiene and Tropical Medicine-University of LondonReid, Donald D -..-... .U.S.-U.K. joint studies in cardiorespiratory disease.


London, University ofAmoroso, Emmanuel C. Electron microscopy of comparative morphologic

problems.Dutton, Richard lW,----- Biochemical mechanism of antibody formation -..--Eysenck, Hans J ....-.. Eñects of stimulant and depressant drugs .........Zaimis, Eleanor ......... On the action of anticholinesterase drugs .........


Royal Free Hospital School of Mediine-Universi ty of LondonDowman, ChailesB .... Autonomic and somatic reflexes of splanchnic

origin.Sherlock, Shella ....-.... Amine metabolism In liver disease.........


Royal Institution of Grest BritainBragg, Lawrence ..---.-- The structures of biological molecules-........


G-7399C1..... 1-D-1346......... 27

E-3961 ........ 13

A-4786 .--- 22

E-1772C281... 1

E-36,i0 -..... . 17

A-5008 ..-. ... 04

C-3188C4 -.. . 12

A-4303 ......-. 33

D-1240 .--- 5

H-4775S 1...-.. 56

G-6489C1 ...- 27

E-2911C1I .-.. 13MI-2612C2..... 51B-2474RI -- 14

B-3171 - - 9

A-4267 .....-.. 22

A-2-,91C2-.._. 1

$24,1009, 680

20,000

6,000

1,372

22,000

11, 210

150,000

14,206

9,000

20,000

8, 625

13, 2119.660

10 752

11,015

16,800

25,300

.

4. Research Projecs Granls



LONDON-Continued

St. Bartholomew's Hospital Medical College-University of London

Bourne, Gordon L ...... Electronmicroscopice study of human amnion.......Institution total, 1 grant, $2,071

St. George's Hospital Medical School-Universiity of LondonMcKissock, Wylie ..... Cooperative clinical study of aneurysms.........

Do ..........- . Cerebrovascular accident research center ...--Institution total, 2 grants, $66,722

St. Mary's Hospital Medical Sehool-University of London

Neuberger, Albert .-... .Structural and enzymological studies of glycopro-telns.


University College-Univeraity of London

Abercrombie, M -.. . ... Control of cell locomotion in relation to mallgnancy.Do .....-..... ... do......................

Blest, A. D -..... Behavioral Interaction and aging in saturniidmoths.

Medawar, Peter B --..- . Nature of antigens responsible for homograft reac-tion.

Do ...-........ do .... ..............Penrose, L. S -.....- Mapping of human genes by cell culture......Schild, Heinz O -....-. . Psychotropic drugs and autonomic dysfunction -.-.Summerfield, Arthur.. - Psychopharmacology of learning, perception, and

skill.Institution total, 8 grants, $102,625

World Federation for Mental Health

Soddy, K ..-..-.-. ... International interprofessional study group-June1961.


G-7124CI .-.... 7

B-2421C2..... - 41B-3138 -...... 19

G-8171 ---- 26

C-484781 .-.... 27C-4847C1 -.--- 27G-7109CI---- 17

E-3137C1 .- 13

E-3137C1S61 ..0-6984C1 ..-..M-3561C1 ....M-3313C1......

13295151

MM-4998 ....... 96

OXFORD

Oxford, UniverSity of

Clegg, Marguerite D ..... Irradiation of single cells by alpha-particle miero- A-2508C2- .... 31beams.

Krebs, Hans A -.. 4.. .. Aspects of intermediary metabolism-..-....... A-3369CI ...... 26Pirenne, M. H -..------- Vision and light quanta .--........... .. B-1810C2 .---- 1Stewart, Alice M-...... The survey approach to problems of cancer preva- C-5392 .- ...... 15

lence.Truelove, Sidney C0..- Motility in health and disease .-.... ........ A-5123-...... 22Whitehouse, Michael.... Cholesterol catabolism fn mammalian tissues .-... H-5472 .-. --- 26


Sir William Dunn School of Pathology-Oxford Unirerity

Florey, Howard W - T... .The occurrence of atheeroselersis in aging pigs...... 1-5932 .-. . ._ .. 97Institution total, 1 grant, $3,450

READING

National Institute for Research in Dairng~Scott-Blair, G. W -..... Rheology of blood In flow and coagulation .------. HI-5732- ....... 6


Reading, Universlty of

Ditchburn, R. W .----- Eye movements in relation to visual perception ... B-1233C4_ 8-. - 30Institution total, 1 grant, $12,650

$2.071

18,72248,000

28,100

46512, 7721,120

12, 932

1,0089,947

20, 76423,614

47,150

7,050

50,60011,55014,784

29,8756, 325

3,460

14,317

12,6W0

e

Listing by Geogrophic Areo and Grantee Institution

Investigalor Project title Grant No. S.S. Dollars

UNITED KINGDOM-ContinuedTWICKENHAM

General Practitioner Researeh GruupWheatley, David P .---- Use of psychotherapeutic drugs in general practice. M-4135 .....- ._ 51

Institution total, I gant, $5,000

INDIVIDUAL GRANTS

Hill, William C -......... Anatomical atlas of the rhesus monkey ..-.-.-. 0.. G-76...87. - 82Hunter, Richard A .-. .Anthology ol British psychiatry .-.. ---- M-4721 ...- .... 93Weiner, Joseph S .- ... Genetic studies of several racial groups .- . . .0...... 0-7297 -.. ... 29

Institution total, 3 grants. $21,530

STATE TOTAL, 58 grants ....... _....--

$5,000

7,0808,400, 050

1,02, 781

URUGUAYMONTEVIDEO

Instituto de Investigalon de Ciencia Biolagiis

Sotelo, J. R .-........ .Study on the fine structure ofmeiotieehromosomes. 0-8337-...3... 27 26.190Institution total, 1 grant, $26,190

University of the RepublieDi Bello, Raul -...... Diagnosis and clinical forms crdiae echlinococcosis. E-3612 .-..-. . .- 17 2,000Sica-Blanco, Y ....-... Physiology and pharmacology of milk ejection in A-5070 ---.---- 7 15,200

women.Temesio, Nellye .-------- Hemolytie anemias In chlidren .-..... . .... RF-12 .--.-- 68 2, 875

Institutton total, 3 grants, $20,075

STATE TOTAL, 4 grant s.---.--------------------------------------------------------------- 46,265

WEST GERMANYGOTTINGEN

Faculty of Medicine, University of Gottingen

Beuren, Alois J -.. M.. . ... etabolism of the normothermic and hypothermic E-5582 .-.. - 4 10. 879heart.

Institution total, 1 grant. $10,879

Gottingen, Univernlty of

Thurau, Klaus W .-... Renal hemodynamics in unanestbetfzed dogs ....- RP-2 .....-.. 58 2.875Institution total, 1 grant, $2,875

HAMBURG

Second Medical Clinic, Hamburg UnivereltyNowakowski, Henryk-.. European Cooperative Breast Cancer Oroup ....-. C-4893 ....-.. 12 7, 920

Institutional total, 1 grant, $7,920

HEIDELBERG

Heidelberg, University of

Dengler, Hans J ....- .. _ Endocrine effects on catechololamlnes.......Institution total, 1 grant, $2,500

RF-13 ........ 58

Institut fir Experimentale Krebsaforschug-Unlversity of Hedelberg

Lettre, Hans H--. . .... Sterol derivatives in caneer ebemotherapy ....-... C-4821C1 -.... 40Institution total, 1 grant, $13,100

.

2, 00

13,100

4. Research Projecl Grants

Investigator Project titIe Grant No. S.S. Dollars


MARBURG

Marburg, University of

Deicher, HelmuthR ..... Antibodies in Lupus erythemGtosus and other A-4450 -.. . .... 22 $4,050diseases.


TUBINGEN

Max Planck Institute for Virus Researcb

Schramm, Gerhard F.... Funetion of nuelelc acid in virus synthesis .-. . C-4601CI ----- 25 12,650Institution total, 1 grant, $12,650

STATE TOTAL, 7 grants ....-- ... . ..... 539.7...... ...... .......-. 4.. 53, 94

YUGOSLAVIAZAGREB

Central Institute of Hyglene

Buzina, Ratko .- . ....... Epidemiology of heart disease in Yugoslavia....-.. H-4774C1 ..- 34 5,000Institution total, 1 grant, $5,000

STATE TOTAL, 1 grant -.....-.. -............. , 5,000

e

O

r'

NATIONAL INSTITUTES OF HEALTH Public Health Service

PRINCIPAL INTERNATIONAL ACTIVITIES

RESEARCH GRANTS TO FOREIGN INSTITUTIONS

AND INTERNATIONAL ORGANIZATIONS

FELLOWSHIPS TO AMERICANS FOR FOREIGN STUDY

- Pre-doctoral

- Post-doctoral

- Special

POST-DOCTORAL FELLOWSHIPS IN UNITED STATES

FOR FOREIGN SCIENTISTS

TRAINING

-Grants to foreign institutions including stipends for U.S. citizens

-Stipends permitting'some foreign nationa-ls under training grants

to U.S. institutions

-Troineeships abroad for training American scientists in

special skills

INTERNATIONAL CENTERS FOR MEDICAL RESEARCH AND TRAINING

SPECIAL FOREIGN CURRENCY PROGRAM UNDER PL 480

EXAMPLES OF INTERNATIONAL ACTIVITIES OF INTRAMURAL PROGRAIAS

-Non-Citizen visiting scientists and fellows

- Seato-Pakistan Cholera Research Laboratory

- NIH West African Research Unit

-Participation in International Committee on Nutrition

in the National Defense

-Middle America Research Unit

-Participation in U.S.-USSR Exchange Program

OFFICE OF INTERNATIONAL RESEARCH

PROGRAM ANALYSIS SECTION

MAY 4. 1962


FUNDS COMMITTED FOR PRINCIPALINTERNATIONAL ACTIVITIES- 1961

AE

AMOUNT $ %

A. FOREIGN RESEARCH GRANTS 9,210,900 34.0

B. FELLOWSHIPS TO AMERICANS FOR FOREIGNWORK AND STUDY 1,586,500 5.9

C. FELLOWSHIPS TO FOREIGN SCIENTISTS FORWORK AND STUDY IN U. S. 726,300 2.7

D. STIPENDS TO FOREIGN NATIONALS UNDER (APPROX)DOMESTIC TRAINING GRANTS 10,000,000 36.9

E. TRAINING GRANTS TO FOREIGN INSTS. INCL.STIPENDS FOR AMERICAN TRAINEES 251,300 0.9

F. TRAINEESHIPS ABROAD FOR AMERICANS TOOBTAIN SPECIAL SKILLS 268,200 1.0

G. VISITING FOREIGN SCIENTISTS AND FELLOWS 869,200 3.2

H. INTERNATIONAL CENTERS FOR MED. RES. TNG. 1,800,000 6.6

I. SPECIAL FOREIGN CURRENCY PROGRAM (PL 480) 2,400,000 8.9

TOTAL 27,112,400

OFFICE OF INTERNATIONAL RESEARCH

PROGRAM ANALYSIS SECTION

MAY 4, 1962


s GRANTS TO INTERNATIONAL ORGANIZATIONSAS PERCENT OF TOTAL FOREIGN GRANTS

FY 1961

INTERNATIONAL ORGANIZATIONS, 135%

/ WHOPAHO

*i· oTHER

· FOREIGN INSTITUTIONS $ 7,987,654 87 %

* INTERNATIONAL ORGANIZATIONS $ 1,223,292 13

WHO $ 282,940 3

PAHO & INCAP $ 621,667 7

OTHER $ 318,685 3

TOTAL $ 9,210,946 100

OFFICE OF INTERNATIONAL RESEARCHPROGRAM ANALYSIS SECTIONMAY 4. 1962

NATIONAL INSTITUTES OF HEALTH Public Health Servico

RATE OF GROWTH OF RESEARCH GRANTS$1,000,000,000

$100,000,000

$10,000,000

$1,000,000

O 1F.Y. 55

ALL REGULAR RESEARCH GRANTS

F.Y. 60 61 62

FOREIGN RESEARCH GRANTS

SIX LEADING FOREIGN COUNTRIES

.,e

,,

ARITHMETIC SCALIFOR COMPARISON

57 58 59

OFFICE OF INTERNATIONAL RESEARCHPROGRAM ANALYSIS SECTIONMAY 4, 1962


* GROWTH OF FOREIGN RESEARCH GRANTSSELECTED COUNTRIES

$0001,200

800

400

1,200

800

400

1,200 -

n afl

55 56 57 58 59 60 61

JAPAN

1 1

dnn__

1_' __ J_ _

1,200-

Qnn

400

55 56 57 58 59 60 61

ITAL'

LiI--l ./55 56 57 58 59 60 61

$ooo

1,200

800

400

1,200 -

800 -

Ann

1,200 -

o Af

ISRAEL

55 56 57 58 59 60

FRANCE

400

55 56 57 58 59 60 61

OFFICE OF INTERNATIONAL RESEARCHPROGRAM ANALYSIS SECTIONMAY 4. 1962

61r F _ ·

_ _= r_

NATIONAL INSTITUTES OF HEALTH

AMOUNT OF FOREIGN RESEARCHGRANTS BY GEOGRAPHIC REGION

FY 1961

GRAND TOTAL -573 GRANTS = $9,210,946

WEST HEMISPHEREGRANTS

137AMOUNTS2,076,152

CANADA 80 1,198,556LATIN AMERICA 57 877,596

EUROPE 251 3,683,674

AFRICA 18 399,602

MIDDLE EAST 62 837,592

ISRAEL 49 687,699OTHER 13 149,793

SOUTH ASIA &FAR EAST 75 990,714

JAPAN 44 617,624OTHER 31 373,090

INT'L ORGANIZATIONS 26 1,223,292

WHOPAHO & INCAP*OTHER

21311

282,940621,667318,685

'`;íi""""'"'''''''.·.'·'.'.'·'·'·`·'·'·'·'·'·'·:·:·:·.·:·.�'·'·'·'·'·'·'·'·'·'·'·'·'·:·'·:·.·.·.·.'·'·'·'·'·'-'·'·'·'·'·'·'·:·:·:·:·:·:·:·:·:·:·:·:·:·'·'·:·::::::·:.:.:·:·::I::.:.:::i:i:i:i::l:.3: :::::::'"''"';·;·.·.·.·.·.·.···:·-······:·:·:·:·:·:::::::::::::::::::::::::::::::':::::::.�.'·'·'·'·'·`·'·`·`·'·`·'·'·.·:·'·.·.·.'.'·'·'·'·'·'·'·:·:·:·:·:·:·:·:·:·:·:··· · · ·.·.·.·.·.·.·.·.·, .....

* PAN AMERICAN HEALTH ORGANIZATION & INSTITUTE FOR NUTRITION FOR CENTRALAMERICA AND PANAMA


PERCENT

23

__ ............................,....................................................................................................................................................................................................................................................................................................................... ............ . . . . . . . . . . . . ............ ........ .f....................................................................................................................................................................

..,-..............................................................................................,........................ ........

4

11

Public Health Servico


GROWTH OF FOREIGN RESEARCH GRANTS1955-1962

13,000.0

847.21,383.8

110.8 189.6

55

I56

I57

I58I

FOREIGN GRANTS AS PERCENTOF TOTAL RESEARCH GRANTS.

NOTE: INCLUDES GRANTS TO INTERNATIONAL ORGANIZATIONS


9,210.9

5,441.8

$ 15

10

MILLIONS

OF

DOLLARS

5

o

F.Y.

4

3

PERCENT2

1

o

3,070.4

59I

60 61I

62EST'D.

4.2

NATIONAL INSTITUTES OF HEALTH Public Health Servico

FOREIGN GRANTS AS PERCENT OF TOTALGRANTS IN SELECTED SUBJECT CATEGORIES

AVERAGE (ALL CATEGORIES)

IPERCENT

DISEASES AND BODY CONDITIONSNUTRITION & DEFICIENCY DISEASES

ALLERGYTOXICITY & POISONINGMETABOLISM & MET DISEASESINFECTIOUS DISEASES

CANCERINJURY AND SHOCK

DENTAL DISEASES AND CONDITIONSRADIATION EFFECTS

INTOXICATION & DRUG ADDICTIONOCCUPATIONAL DISEASESMENTAL HEALTH

MAJOR BODY SYSTEMS

BLOOD

DIGESTIVENERVOUS

ENDOCRINEMUSCULOSKELETALINTEGUMENTARY

CARDIOVASCULARSENSORY ORGANS & SYSTEMSUROGENITAL

LYMPHATICRESPIRATORY

?.6

-: ::::.:::i 2.4:.:..: 1.9

::::1 1.8

1.1

4.0

4.03.5

3.3

21 .

:'-!- ...'.: 2.4::::::::::::::1.8

EMl~i~ .i


PAN AMERICAN HEALTH ORGANIZATION FIRST MEETING

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Transcript of PAN AMERICAN HEALTH ORGANIZATION FIRST MEETING