Mitotic Oscillators as MP Graphs

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Transcript of Mitotic Oscillators as MP Graphs

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ATP + Cdc25A + Chk1 → ADP + phosphoCdc25Añ,/

0

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ATP + Cdc25A + Chk2 → ADP + phosphoCdc25Añ,/

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phosphoCdc25A → phosphoCdc25A@Cytosolñ,/

2

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3

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phosphoCdc25A@Cytosol + Ubiquitin + UbiquitinLigase →

UbiquitinatedphosphoCdc25A@Cytosol + UbiquitinLigaseñ,/

3

ò

UbiquitinatedphosphoCdc25A@Cytosol + proteasome26s →

AminoAcid + proteasome26s.ñ /

4

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mitosis arrest degradation

DNA damage

Chk1, Chk2 Chk1+, Chk2+

ATP

ADP

Cdc25A

PhosphoCdc25AUbiquitin

UbiquitinatedphosphoCdc25A

AminoAcid

CyclinE−cdk2CyclinE−cdk2+

Ub−Ligase

Proteasome26s

J3

R4

h3

h4

R1

R2

R3

J4

f1

f2

h2

K1

K2

h1

f4

f3

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