Interventions for alcohol and drug problems in outpatient settings: A systematic review
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Transcript of Interventions for alcohol and drug problems in outpatient settings: A systematic review
COMPREHENSIVE REVIEW
Interventions for alcohol and drug problems in outpatient settings:A systematic review
JUDITH M. WATSON1, DEBRA FAYTER2, NOREEN MDEGE1, LISA STIRK2,AMANDA J. SOWDEN2 & CHRISTINE GODFREY1
1Department of Health Sciences, University ofYork, York, UK, and 2Centre for Reviews and Dissemination, University ofYork, York, UK
AbstractIssues.Research evidence indicates a high prevalence of substance abuse among patients presenting in general hospital settings.Such misuse of alcohol and illicit drugs has a major impact on population health and on costs to health services and to societyat large.This review aimed to identify the interventions for alcohol or illicit drug misuse problems that have been evaluated forhospital outpatient populations. Approach. Thirteen electronic databases including MEDLINE, EMBASE and PsycInfowere searched for published and unpublished studies in any language up to August 2011. Reference lists of included studies andreviews were also hand-searched.We included randomised and controlled clinical trials of any intervention for adult participantsidentified as having alcohol and/or drug problems presenting to hospital outpatient settings other than addiction or psychiatricunits. Participants could be attending hospital for any reason other than treatment for substance abuse. A narrative synthesiswas conducted. Key Findings. There is some evidence to suggest that interventions based on motivational techniques mightbe effective in treatment of alcohol misuse in oral–maxillofacial clinics but not in general outpatient departments.The evidenceis insufficient to allow any conclusions to be derived on the effectiveness of interventions in the treatment of drug misuse andcombined alcohol–drug misuse in outpatient settings. Conclusions. Further research is needed to investigate interventions foralcohol and drug misuse in outpatient settings.Additionally, problems remain in terms of study quality. Procedures to ensure therigour of a study were often poorly reported. [Watson JM, Fayter D, Mdege N, Stirk L, Sowden AJ, Godfrey C.Interventions for alcohol and drug problems in outpatient settings: A systematic review. Drug Alcohol Rev2013]
Key words: alcohol problem, drug problem, outpatient, treatment.
Background
Alcohol consumption is reported as the world’s thirdlargest risk factor for disease and disability, with almost4% of all deaths worldwide attributed to alcohol [1]. Inaddition, the misuse of illicit drugs accounts for the lossof 11.6 million disability-adjusted life years annuallyworldwide, which is 0.8% of the total burden of disease[2].
Although an increasing awareness of recommendedsafe drinking limits has developed in England, it is
estimated that over 24% of the adult population arehazardous drinkers [3], and alcohol-related hospitaladmissions have risen by 69% from 2002 to 2007/2008,now standing at 863 300 [4]. Likewise, around fourmillion people use illicit drugs each year in the UK, anda total of 42 170 admissions with a primary or second-ary diagnosis of drug misuse were noted in 2008/2009[5].
Health-care professionals across a range of hospitalsettings will regularly encounter patients with substancemisuse problems and may have an opportunity to inter-
Judith M.Watson PhD, Research Fellow, Debra Fayter MSc, Research Fellow, Noreen Mdege MSc, Research Fellow, Lisa Stirk MSc, InformationSpecialist, Amanda J. Sowden PhD, Deputy Director, Christine Godfrey BA, Emeritus Professor. Correspondence to Dr Judith M. Watson,Department of Health Sciences,York Trials Unit, ARRC Building—LG Floor, University ofYork, Heslington,YorkYO10 5DD, UK. Tel: +44 (0)1904 321306; Fax: +44 (0) 1904 321387; E-mail: [email protected]
Received 18 October 2012; accepted for publication 8 February 2013.
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Drug and Alcohol Review (2013)DOI: 10.1111/dar.12037
© 2013 Australasian Professional Society on Alcohol and other Drugs
vene. If a condition is potentially related to misuse ofalcohol and/or illicit drugs, some patients may, on dis-cussion, realise the association between their substancemisuse and their ill-health, potentially providing what isknown as a ‘teachable moment’ [6].
Treating substance misuse can result in substantialcost savings, with recent estimates suggesting that forevery £1 spent on treatment for drug problems, at least£9.50 can be saved in criminal justice and health costs[7]. In 2008, the Department of Health estimated thatthe costs to the health service because of alcohol misusewere in the region of £2.7 billion per year [8].There isgrowing interest and need for early detection of patientswith such substance misuse problems [9].
A number of systematic reviews already exist in thefield of drug and alcohol misuse [10–13]. However,none focus solely on outpatient settings and oftenconsider a single type of intervention (e.g. brief inter-vention). In this review, we were interested in theeffectiveness of any intervention offered in hospital out-patient settings to patients who might not know theyhave an alcohol or drug misuse problem and/or mightnot seek help.
Methods
This review was undertaken according to the principlesrecommended in the Centre for Reviews and Dissemi-nation guidance [14].This includes the production of adetailed protocol, which is available at: http://www.york.ac.uk/healthsciences/trials-unit/arias/links/.
Search strategy
The following electronic databases were searched forcontrolled trials (randomised and non-randomised)published up to August 2011: MEDLINE;C2-SPECTR; CINAHL; Cochrane Central Register ofControlled Trials; Cochrane Database of SystematicReviews; Conference Proceedings Citation Index -Science; DARE; EMBASE; HMIC; HTA Database;NHS Economic Evaluations Database; PsycInfo; andPublic Health Interventions Cost Effectiveness Data-base. Full search strategies for each database searchedare provided in Appendix S1.
The reference lists of included papers were assessedfor additional relevant studies, and ongoing studieswere identified from ClinicalTrials.gov (via websiteat: http://www.clinicaltrials.gov/). Where necessary,authors of ongoing or unpublished studies were con-tacted for further information so as to assess eligibilityfor the review.
Identification of included studies
Two reviewers independently screened all titles andabstracts. The full manuscripts of potentially relevant
studies were retrieved and assessed for relevance inde-pendently by two reviewers according to the inclusioncriteria. Discrepancies were resolved by discussion orby referral to the project team when necessary.
Inclusion criteria
We included studies recruiting participants aged 16 orabove, identified as having an alcohol and/or drugproblem (as per each study’s inclusion criteria) present-ing to an acute hospital outpatient setting for anyreason other than specifically for alcohol or illicit drugmisuse treatment. All levels of severity of alcohol abusewere eligible including severe dependence.We includedrandomised controlled trials (RCT) (individual orcluster) and controlled clinical trials (CCTs). Any typeof intervention was eligible for inclusion and could haveone or more components, pharmacological and non-pharmacological, be delivered to individuals or groupsface to face or using the telephone or other media.Comparator interventions could include no treatment(assessment only without referral), waiting list control,‘usual care’ or other active treatments. Studies wherereferral to specialist services was the purpose wereincluded. Outcomes could include: a measure ofalcohol consumption (e.g. quantity/frequency, percent-age of time abstinent and alcohol questionnaire scores);a measure of drug use (e.g. number of days used anddrug questionnaire scores); biochemical measures ofalcohol use; injury; mortality rates; quality of life meas-ures; numbers seeking specialist treatment for alcohol/drug misuse; criminal offences (e.g. driving whileintoxicated and assault) and motivation/readiness tochange. Published and unpublished studies from anycountry and reported in any language were eligible forinclusion.
Interventions directed primarily at whole hospitalpopulations without screening for alcohol or drug prob-lems and those screening patients solely to ascertainprevalence of substance misuse problems were not eli-gible.We also excluded: studies focusing specifically onparticipants with a dual diagnosis and abuse of pre-scription medications and studies set in specialist psy-chiatric wards/facilities, addiction services or addictiontreatment programmes. Studies focusing specifically onpregnant women were also excluded as we consideredthem to be a separate group and one that has beenadequately reviewed elsewhere [15,16].
Data extraction
Following piloting of a selection of studies to ensureconsistency, data were extracted independently by onereviewer and checked by a second reviewer. Discrepan-cies were resolved by discussion, with involvement of a
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2 J. M. Watson et al.
© 2013 Australasian Professional Society on Alcohol and other Drugs
third reviewer when necessary. Data extracted includedstudy methods, setting, participant characteristics,intervention, comparators, outcomes, outcome meas-ures and results.
Quality assessment
Quality was assessed by one reviewer and independ-ently checked by a second reviewer. Disagreementswere resolved by consensus, and a third reviewer con-sulted if necessary. Items assessed included: presence ofa power calculation, adequacy of randomisation andallocation concealment, appropriate adjustment forcovariates, blinding of outcome assessors, adequacy offollow up (deemed to be a minimum of 12 months) andexplanation of dropouts and use of intention to treatanalysis. Details of attempts to maintain interventionfidelity were recorded (e.g. adequacy of training forthose delivering the intervention, use of checklists,audio or video taping patient interviews, direct obser-vation, etc.).
Methods of analysis
Significant methodological heterogeneity existedamong the studies, predominately regarding the out-comes reported, how they were defined and meas-
ured. Various measures include: number of drinkingdays in the past 30 days; alcohol consumption in thepast 3 months; mean drinks per drinking day; andchange in alcohol consumption at 12 months. Therewere also differences in baseline consumption levelsfor eligibility, the health-care professionals deliveringthe intervention and inclusion/exclusion by gender.Given the diversity of the studies included in thisreview, it was considered that a meta-analysis wasinappropriate. A narrative synthesis was conductedand evidence summaries created incorporating anevaluation of the quality of the evidence. This reviewhas been reported in accordance with the PRISMAstatement [17].
Results
The search identified 3699 potentially relevant refer-ences (Figure 1), which were screened, and 396 wereretrieved for detailed evaluation. Of these, 334 wereexcluded due to not being related to drug or alcoholproblems, not in a general hospital setting, or not anRCT or controlled clinical trial. A further 55 wereexcluded for being conducted in emergency (n = 34)and inpatient settings (n = 21).
Seven were conducted in outpatient settings and arepresented in this paper.
Titles and abstracts screened from
electronic searches n = 3631
Full papers screened
n = 396
Included in full review
n = 7
Excluded
n = 389
(Not drug or alcohol
problems, not an RCT or CCT
participants under 16, not a
general hospital setting;
emergency or inpatient
setting)
Interventions for alcohol
misuse
n = 5
Interventions for drug
misuse
n = 1
Interventions for alcohol
and drug misuse
n = 1
Ide
ntifica
tio
n
Scre
en
ing
E
ligib
ility
In
clu
de
d
Ongoing studies identified
from ClinicalTrials.gov n = 2
Papers identified from
checking reference lists n = 68 Excluded n = 3303
(Duplicates; not relevant)
Figure 1. Flow chart showing the number of potentially relevant references identified during the searches and the number included inthe review.
Outpatient alcohol and drug interventions 3
© 2013 Australasian Professional Society on Alcohol and other Drugs
Description of included studies (Table 1)
Five studies investigated the effectiveness of interven-tions for excessive alcohol use [18–22]; one investigatedinterventions for drug misuse [23]; and one for bothexcessive alcohol and illicit drug use [24]. Three wereconducted in the USA [20,23,24], two in the UK)[18,19], one in the Netherlands [21] and one inSweden [22].
Interventions for alcohol misuse
Five RCTs including a total of 1058 adult participantswere included in the review [18–22]. Study interven-tions were compared with usual care (which may haveincluded advice on alcohol) [19,21]; provision of astandard alcohol information leaflet [18]; assessmentinterview only [20]; and, in one study, no contact for 12months [22]. Results are presented in a narrative syn-thesis. It was hoped to divide the studies according tothe behavioural change techniques used in the interven-tions, following the framework proposed by Abrahamand Michie [25]. However, this was hampered due topoor reporting of intervention content and behaviourchange techniques.
Effectiveness of the evaluated interventions foralcohol misuse
Alcohol consumption. One of the two studies con-ducted in oral and maxillofacial outpatient clinicsfound no statistically significant treatment differencesat 3 months (based on 103 of 195 participants ran-domised) regarding changes in number of drinkingdays or number of standard drinks per drinking day[18]. However, at 12, months there was a statisticallysignificant difference between the treatment groups infavour of the motivational intervention in terms ofchange in drinking days (P = 0.007) and heavy drinkingdays (P = 0.03).This was not the case for the number ofstandard drinks per drinking days (P = 0.2) [18]. In thesecond study, there was a significantly greater reductionin the percentage of hazardous drinkers in the motiva-tional intervention group compared with the controlgroup [19]. Although the number of days abstinent didnot vary significantly between groups, at 12 months,only 27% of the intervention group were drinkingabove the guidelines of 21 units per week [decreasefrom 45/75 (60%) to 16/60]; in the control group, 51%were drinking above the guidelines [decrease from41/76 (54%) to 31/61] [19].There was also a significantinteraction effect for time and treatment for thisoutcome favouring the motivational intervention(F = 3.60, P < 0.029), with significant differencesbetween the treatment groups at both 3 and 12 months
[19]. This pattern was repeated for alcohol consump-tion in a typical week with a significant main effect fortime (F = 4.59, P < 0.011) and significant interactionfor time and treatment (F = 3.30, P < 0.039) [19].
Within the studies conducted in various outpatientclinics, the all-female study comparing assessmentinterview plus brief intervention versus assessmentinterview only found no significant differences betweentreatment groups for all drinking outcomes at 12months [20]. The mean difference in change in drinksper drinking day (adjusted) was -0.06 (-0.3, 0.18)P = 0.63; mean difference in change in percentagedrinking days (adjusted) was 3.0 (-0.1, 6.0) P = 0.07;mean difference in change in number of binge episodes(adjusted) was -2.2 (-4.9, 0.54) P = 0.11; and meandifference in change in number of weeks exceedingsensible drinking limits (adjusted) was 0.27 (-1.2,0.65) P = 0.57. Similarly, the study set in a generalinternal medicine outpatient clinic reported, at a meanfollow-up of 28 weeks, a reduction in alcohol consump-tion over time but no significant differences betweenthe Dutch Motivational Drinkers Check-up (Doorlich-ting, Voorlichting Alcoholgebruik; DVA) and thecontrol, routine hospital care [DVA change 0.81 (2.0);control change 0.84 (2.61) units per day, P = 0.46][21].There were no differences in percentage change ofcarbohydrate-deficient transferrin (appears in serumafter high alcohol intake, where some of the transferrinmolecules appear to lack two to four of their terminaltri-saccharides: hence the name carbohydrate-deficienttransferrin [26]) [DVA change 0.052 (0.32); controlchange 0.051 (0.88), P = 0.69] [21].
Conversely, the study conducted in five different out-patient clinics comparing assessment and frequentfollow-ups and feedback versus no contact [22] found asignificant reduction in the mean amount of alcoholconsumed per week from 179 g (� 106 SD) to 117 g(� 101 SD) (P < 0.005) in the intervention group at 12months but did not report changes in the control group.In the intervention group, gamma glutamyl transfease(a well-established biomarker of excessive alcohol con-sumption and liver dysfunction [27]) values were alsosignificantly reduced from baseline but did not differsignificantly from those of the controls.
Alcohol questionnaire scores. Assessing hazardousdrinking using the Alcohol Use Disorders IdentificationTest questionnaire (AUDIT), Smith et al. [19] foundthat in the intervention group, the percentage of haz-ardous drinkers dropped from 95% at baseline to 58%at 12-month follow-up. The corresponding figures inthe control group were 96% and 81%. The sameauthors found a main effect of time (F = 98.32.P < 0.001) but no effect of intervention in terms ofBrief Alcohol Problem Questionnaire scores [19].
4 J. M. Watson et al.
© 2013 Australasian Professional Society on Alcohol and other Drugs
Tab
le1.
Sum
mar
yof
the
stud
ies
cond
ucte
din
outp
atie
ntse
tting
sin
clud
edin
the
revi
ew
Aut
hors
(yea
r)
Alc
ohol
ordr
ugm
isus
e?C
ount
ry,
scre
enin
gse
ttin
gP
arti
cipa
nts:
num
ber
rand
omis
ed(%
mal
e);
mea
nag
e;ba
selin
eda
taIn
terv
enti
onan
dco
ntro
lO
utco
mes
asse
ssed
Goo
dall
etal
.(2
008)
[18]
Alc
ohol
UK
Thr
eeor
alan
dm
axill
ofac
ial
outp
atie
ntcl
inic
s
n=
195
(91%
mal
e);
Med
ian
age
=38
for
wom
en;
28fo
rm
en;
AU
DIT
scor
e8–
40(m
edia
n15
);72
%ha
dbe
enas
saul
ted
Inte
rven
tion
:B
rief
Inte
rven
tion
(mot
ivat
iona
l)de
liver
edby
rese
arch
nurs
e:no
furt
her
deta
ilgi
ven
Con
trol
:S
tand
ard
alco
hol
info
rmat
ion
leafl
et
At
3an
d12
mon
ths:
Num
ber
ofdr
inki
ngda
ysin
the
past
30da
ysN
umbe
rof
abst
inen
tda
ysin
the
past
30da
ysN
umbe
rof
heav
ydr
inki
ngda
ys.
Num
ber
ofst
anda
rddr
inks
/dri
nkin
gda
y.S
mit
het
al.
(200
3)[1
9]A
lcoh
olU
KO
ral
and
max
illof
acia
lsu
rger
yde
part
men
tou
tpat
ient
clin
ic
n=
151
(100
%m
ale)
;M
ean
age
=24
;AU
DIT
>95
.4%
scor
edov
er8;
BA
PQ
—55
.7%
scor
edbe
twee
n2
and
6;A
DD
-SF
—72
.2%
clas
sed
aslo
w-l
evel
depe
nden
ce,
21.2
%m
ediu
m-l
evel
,2.
7%hi
gh-l
evel
;80
%of
inju
ries
wer
eas
saul
tre
late
d
Inte
rven
tion
:M
otiv
atio
nal
Inte
rvie
win
g:du
rati
onan
din
tens
ity
unkn
own,
deliv
ered
bytw
ose
nior
gene
ral
nurs
esC
ontr
ol:
Usu
alca
re
At
3an
d12
mon
ths:
AU
DIT
Bri
efA
lcoh
olP
robl
ems
Que
stio
nnai
re(B
AP
Q)
(five
item
s)S
hort
-For
mA
lcoh
olD
epen
denc
eD
ata
(AD
D-S
F)
90I
drin
kdi
ary
sect
ion—
alco
hol
cons
umpt
ion
inpa
st3
mon
ths
Det
ails
oflif
eev
ents
Cha
nget
al.
(201
1)[2
0]A
lcoh
olU
SA
Out
pati
ent
clin
ics
ata
wom
en’s
hosp
ital
n=
511
(0%
mal
e);
mea
nag
e=
45.1
;m
ean
drin
kpe
rdr
inki
ngda
y=
2.2;
mea
npe
rcen
tage
drin
king
days
=23
;m
ean
num
ber
ofbi
nge
epis
odes
=7.
35;
mea
nw
eeks
>st
anda
rdda
ilylim
its
=3.
8
Inte
rven
tion
:An
asse
ssm
ent
inte
rvie
wan
dB
rief
Inte
rven
tion
(30
min
s)de
liver
edby
phys
icia
nan
din
terv
iew
sat
3,6
&12
mon
ths
Con
trol
:An
asse
ssm
ent
inte
rvie
ww
ith
asi
ngle
12-m
onth
inte
rvie
wto
obta
info
llow
-up
data
At
3,6
and
12m
onth
sfo
rB
rief
Inte
rven
tion
grou
pan
dat
12m
onth
sfo
rco
ntro
lgr
oup:
Mea
ndr
inks
per
drin
king
day
Per
cent
age
drin
king
days
Num
ber
ofbi
nge
epis
odes
(fou
ror
mor
edr
inks
per
occa
sion
)N
umbe
rof
wee
ksex
ceed
ing
Nat
iona
lIn
stit
ute
onA
lcoh
olA
buse
and
Alc
ohol
ism
(NIA
AA
)st
anda
rdda
ilylim
its.
Em
men
etal
.(2
005)
[21]
Alc
ohol
The
Net
herl
ands
Gen
eral
inte
rnal
med
icin
eou
tpat
ient
clin
ic
n=
123
(76%
mal
e);
37%
prob
able
orce
rtai
nal
coho
l-re
late
dm
edic
aldi
agno
sis;
mea
nag
e=
50.0
inin
terv
enti
ongr
oup;
47.9
inco
ntro
lgr
oup
Inte
rven
tion
:B
rief
Mot
ivat
iona
lIn
terv
enti
onan
das
sess
men
t(9
0m
in)
and
feed
back
(60
min
)se
ssio
n1–
2w
eeks
late
rC
ontr
ol:
Usu
alca
re
Fol
low
-up
at23
–36
wee
ks(m
ean
28w
eeks
;S
D=
2.39
,ra
nge
23–3
6):
Sel
f-re
port
edch
ange
inal
coho
lco
nsum
ptio
nas
unit
s/da
yC
hang
ein
carb
ohyd
rate
-defi
cien
ttr
ansf
erri
nfr
omba
selin
eC
hang
ein
read
ines
sto
chan
gedr
inki
ngbe
havi
our
Red
ucti
ons
from
abov
eto
belo
whe
alth
limit
s
Outpatient alcohol and drug interventions 5
© 2013 Australasian Professional Society on Alcohol and other Drugs
Tab
le1.
(Con
tinue
d)
Aut
hors
(yea
r)
Alc
ohol
ordr
ugm
isus
e?C
ount
ry,
scre
enin
gse
ttin
gP
arti
cipa
nts:
num
ber
rand
omis
ed(%
mal
e);
mea
nag
e;ba
selin
eda
taIn
terv
enti
onan
dco
ntro
lO
utco
mes
asse
ssed
Per
sson
&M
agnu
sson
(198
9)[2
2]
Alc
ohol
Sw
eden
Fiv
edi
ffer
ent
outp
atie
ntcl
inic
s
n=
78(7
8%m
ale)
;58
(74%
)de
finit
epr
oble
mdr
inki
ng;
20(2
6%)
prob
able
prob
lem
drin
king
;m
ean
age
not
stat
ed
Inte
rven
tion
:P
hysi
cal
exam
inat
ion
and
clin
ical
asse
ssm
ent.
Mon
thly
follo
w-u
pfo
r12
mon
ths
byhe
alth
prof
essi
onal
sw
here
alco
hol
cons
umpt
ion
and
labo
rato
ryva
lues
wer
edi
scus
sed
and
feed
back
was
give
n.C
ontr
ol:
No
init
ial
cont
act
and
nodi
scus
sion
abou
tal
coho
l
At
12m
onth
s:C
hang
ein
alco
hol
cons
umpt
ion
Sic
knes
sbe
nefit
sV
isit
sto
outp
atie
ntcl
inic
s.H
ospi
tal
adm
issi
ons
Lab
orat
ory
para
met
ers
Ber
nste
inet
al.
(200
5)[2
3]D
rugs
US
AT
hree
outp
atie
ntcl
inic
s(U
rgen
tca
re,
Wom
en’s
Clin
ic,
Hom
eles
sC
linic
)
n=
1175
(70.
6%m
ale)
;46
%w
ere
hom
eles
s;83
%no
tcu
rren
tly
wor
king
;m
ean
age
=37
.8in
inte
rven
tion
grou
p;38
.1in
cont
rol
grou
p
Inte
rven
tion
:M
otiv
atio
nal
Inte
rvie
w(1
0to
45m
in-
aver
age
20m
in)
tailo
red
toin
divi
dual
,ac
tive
refe
rral
san
dw
ritt
enha
nd-o
utan
dde
liver
edby
peer
s(e
xper
ienc
edsu
bsta
nce
abus
eou
trea
chw
orke
rsin
reco
very
).B
oost
erph
one
call
10da
ysla
ter
(5–1
0m
ins)
Con
trol
:Wri
tten
hand
-out
only
At
6m
onth
s:A
bsti
nenc
efr
omco
cain
ean
d/or
hero
inas
mea
sure
dby
radi
oim
mun
oass
ayof
hair
(als
ore
duct
ion
inus
e)C
onta
cts
wit
hsu
bsta
nce
abus
etr
eatm
ent
syst
emA
ddic
tion
Sev
erit
yIn
dex
Gilb
ert
etal
.(2
008)
[24]
Alc
ohol
and
drug
s
US
AF
ive
outp
atie
ntH
IVcl
inic
s
n=
476
(79%
mal
e);
mea
nag
e=
44.1
;18
2(3
9%)
repo
rted
risk
ydr
inki
ng;
200
(42%
)re
port
edill
icit
drug
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rven
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6 J. M. Watson et al.
© 2013 Australasian Professional Society on Alcohol and other Drugs
Health-care utilisation. Persson and Magnusson didnot find a significant difference between groups interms of health-care consultations, and due to the smallnumber, were unable to analyse admissions to hospitalwards [22].
Motivation/readiness to change. Emmen et al. foundthat although in total, 32% of those patients who weredrinking above health limits at follow up did change toa high motivational stage, no statistically significant dif-ferences between the two groups were found (interven-tion group 39.3%, control group 25.0%, P = 0.091)[21].
Interventions for drug misuse
We identified only one study evaluating interventionsfor drug misuse in an outpatient setting [23] wheremotivational interviewing plus a hand-out and a follow-ing booster session was compared with a control (hand-out only). Participants were mostly male (70.6%), andthose undergoing treatment for drug abuse wereexcluded [23].
Effectiveness of the evaluated intervention for drug misuse
Abstinence. Participants who had received the motiva-tional interview, hand-out and booster telephone callwere more likely than the controls to be abstinent at 6months from cocaine [22.3% vs. 16.9%, odds ratio(OR) 1.51; 95% confidence interval (CI) 1.01, 2.24,P = 0.045] and from opiates (40.2% vs. 30.6%, OR1.57; 95% CI 1.00, 2.47, P = 0.050) [23]. Abstinencefrom both drugs did not differ between groups (17.4%vs. 12.8%, OR 1.51; 95% CI 0.98, 2.26, P = 0.052)[23].
Reduction in drug levels and self-reported contact withtreatment services. Although levels of cocaine andheroin measured in hair samples were significantlylower at follow-up for the whole study sample, thedifferences between groups on levels of cocaine merelybordered on significance, and there was no significantdifference for heroin. No differences were seen betweengroups regarding contact with substance abuse treat-ment services at 6 months (39% in intervention group,37% in the control group). For the majority, however,this consisted of detoxification only. In all AddictionSeverity Index subscale scores, both the interventionand control groups improved. On the drug subscale,there was a 49% reduction in the intervention groupand a 46% reduction in the control group (P = 0.06),and on the medical subscale, a 56% reduction in theintervention group and 50% reduction in the controlgroup (P = 0.055) [23].
Interventions for alcohol and drug misuse
Only one study investigating the effectiveness of inter-ventions for both excessive alcohol and illicit drug usein outpatient settings was identified [24]. The studyevaluated a Positive Choice ‘Video Doctor’ intervention;a laptop-based interactive programme with risk-reduction messages based on the principles of Motiva-tional Interviewing [24]. This was followed up by abooster session 3 months after the first session. An‘Educational Worksheet’ was given to the patient withquestions for self-reflection, harm reduction tips andlocal resources. A ‘Cueing Sheet’ allowed the healthprofessional to indicate whether a discussion had takenplace on the various areas. The intervention was tai-lored to participant’s gender, risk profile and readinessto change. The control group did not use the ‘VideoDoctor’ nor receive the Educational Worksheet andCueing Sheet. Instead, after the risk assessment, theyreceived usual care [24].
There was no exclusion criterion for very heavy/dependent drinkers, or dependent drug users and nonespecified for those who had previously received or werecurrently receiving treatment for excessive alcoholand/or illicit drug use [24]. Information was notreported on the proportion of participants who fell intothese categories.
Effectiveness of the evaluated intervention for alcohol anddrug misuse
The authors reported that the intervention group wasstatistically significantly less likely than the usual caregroup to report any ongoing drug use at 3 months(67% vs. 82%, relative risk (RR) 0.81, 95% CI: 0.689,0.957, P = 0.014) and at 6 months (56% vs. 86%, RR0.65, 95% CI: 0.540, 0.785, P < 0.001) [24]. Therewas, however, no statistically significant differentbetween the groups at both those time points on: reduc-tion in total days of any drug use in the previous monthand cessation of risky drinking [24].
Study quality and fidelity (Table 2)
Of the two alcohol trials set in oral and maxillofacialoutpatient settings, the study by Smith et al. [19]appeared to be of better quality than that of Goodallet al. [18]. Although dropouts did occur in both trials,Smith et al. [19] clearly reported dropout reasons(19%), whereas Goodall et al. did not (31%) [18].Goodall et al. also failed to make it clear as to whetherthey had used intention-to-treat analysis.
Of the three alcohol trials set in general outpatientsettings [20–22], only one provided a power calculationto determine sample size [21]. None clearly explained
Outpatient alcohol and drug interventions 7
© 2013 Australasian Professional Society on Alcohol and other Drugs
the methods of randomisation or allocation conceal-ment, nor were any outcome assessors blinded [20–22].Emmen et al. [21] did not conduct adequate follow-up(�12 months), although intention-to-treat analysis wasused and reasons for dropout was explained. Dropoutwas reported by Chang et al. [20] as 4% and 9% in thetrial by Emmen et al. [21].
In the drug study conducted by Bernstein et al., allo-cation concealment was not adequately reported [23].The study only had a 6-month follow-up (dropout of18%) and did not use an intention-to-treat analysis[23]. When reporting their alcohol and drugs study,Gilbert et al. provided the most information [24],although follow-up was only for 6 months and loss tofollow-up at the end of the study was 17.6% [24].
With regard to fidelity, Smith et al. described thetraining given to the interventionists and how they hadmaintained intervention fidelity through supervisionand review of audio-taped intervention sessions [19].Goodall et al. reported only training of interventionists[18]. Both Chang et al. and Emmen et al. reportedmethods used to ensure intervention fidelity (includingtraining staff and reviewing interventions using obser-vations or checklists) [20,21]. Persson and Magnussondid not report any such measures of intervention fidel-ity [22].
In the trial conducted by Bernstein et al., extensiveattempts were made to ensure the integrity and fidelityof the interventions delivered [23].These included role-plays, supervised patient interviews and form comple-tion demonstrating completion of key elements of theintervention. In the study by Gilbert et al., the interven-tion used a computerised ‘Video Doctor’, which stand-ardised messages, which the authors report may havehelped increase fidelity to the principles of MotivationalInterviewing [24].
Discussion
The objective of this review was to identify the inter-ventions for alcohol or illicit drug misuse problemsevaluated for hospital outpatient populations and deter-mine, from the available evidence, which of theseinterventions can be effectively delivered for thesepopulations.
Interventions for alcohol misuse
The results from this review suggest that interventionsbased on motivational techniques may be effectiveamong patients with alcohol problems identified inoral–maxillofacial clinics. However, the optimumnature and duration of the intervention in this popula-tion group is unclear and would be worthy of further
Tab
le2.
Inte
rven
tions
inou
tpat
ient
setti
ngs:
anov
ervi
ewof
stud
yqu
ality
Stu
dyP
ower
calc
ulat
ion
Ran
dom
isat
ion
adeq
uate
Allo
cati
onco
ncea
lmen
tad
equa
te
Adj
uste
dfo
rba
selin
ech
arac
teri
stic
sP
arti
cipa
nts
blin
ded
Out
com
eas
sess
ors
blin
ded
Fol
low
upad
equa
te(�
12m
onth
s)D
ropo
uts
expl
aine
d
Inte
ntio
nto
Tre
atan
alys
isus
ed
Goo
dall
etal
.(2
008)
[18]
✗?
✗✓
✗✓
✓✗
?S
mit
het
al.
(200
3)[1
9]✓
✓✓
??
✓✓
✓✓
Cha
nget
al.
(201
1)[2
0]✗
✓✗
✓✗
?✓
✓✓
Em
men
etal
.(2
005)
[21]
✓?
?✓
✗✗
✗✓
✓P
erss
on&
Mag
nuss
on(1
989)
[22]
✗?
?✓
?✗
✓✗
✗B
erns
tein
etal
.(2
005)
[23]
✓✓
✗✓
✓✓
✗✓
✗G
ilber
tet
al.
(200
8)[2
4]✓
✓✓
✓✓
✓✗
✓✓
✓=
yes.
✗=
no.
?=
uncl
ear.
8 J. M. Watson et al.
© 2013 Australasian Professional Society on Alcohol and other Drugs
research. Nor is it clear if women would respondequally to the intervention as the samples comprisedmainly of men.
The three other trials [20–22], conducted in diversesettings, did not generally find positive effects of briefinterventions to decrease alcohol consumption andrelated outcomes. Chang et al. suggest their findingswere due to reactivity to the assessment that lasted anhour; regression to the mean; and presence of medicalconditions that may motivate changes in drinking inboth groups [20]. Similarly, the study by Emmen et al.also included a lifestyle assessment that was received byboth groups [21].
Nonetheless, these findings cannot be taken asdefinitive as most of the trials had weaknesses, includ-ing issues with randomisation and inadequatefollow-up periods. Importantly, most of the studiesfailed to provide adequate detail about the interventioncontent, duration, intensity and delivery. Such lack ofclarity raises issues when trying to compare interven-tions. There is a need for further good quality studieswith adequate follow-up and full reporting of interven-tion content. The authors of the included studies alsoidentified issues that need to be taken into account inthe planning of future research. These are: reactivity tothe assessment, the possible exclusion of those withsevere alcohol dependence and ensuring that controlsdo not receive part of the intervention.The evidence is,therefore, currently insufficient to state whether or notinterventions to reduce alcohol consumption andrelated outcomes are helpful in general outpatientsettings.
The transferability of findings from other health-caresettings, including inpatient and emergency settingswith their different systems, into an outpatient setting isnot clear, but it may be interesting to compare ourfindings with that of primary care where both settingsprovide a similar type of time-limited consultation situ-ation. A review conducted by Kaner et al. [28] consid-ered studies evaluating the effectiveness of briefinterventions delivered in primary care settings, pub-lished up to early 2007.Their meta-analysis of 22 RCTsfound that intervention participants had lower alcoholconsumption than control participants after follow-upof 1 year. However, the benefits for women wereunclear, and the authors recommended furtherresearch to establish the most effective components ofbrief interventions.
We are aware of two ongoing trials evaluating inter-ventions for alcohol misuse in outpatient settings thathave not yet reported results [29,30]. One of these is anintensive three-arm family-based intervention study foryoung people [30], comparing a MultidimensionalFamily Therapy [an outpatient family-based treatmentfor troubled youths of 3 months duration with an
average of two sessions (60–90 min) per week withadditional extra-familial work and phone contacts asneeded], Family Motivational Interviewing (two homesessions within 72 h of the incident, and link with grouptreatment lasting 3 months) and standard care (two90-min group sessions per week for 3 months). Theother is in HIV-positive women [29], looking tocompare a brief counselling intervention including twosessions that review drinking patterns and behaviourchange strategies, plus two telephone calls to reinforcesession content versus standard care. There is a clearneed for trials of interventions for alcohol misuse inoutpatient settings.
Interventions for drug misuse
The evidence for interventions to reduce drug misusein hospital outpatient settings is limited to one trial[23], and currently, the evidence is insufficient to allowany conclusions to be derived about effectiveness. Thesuggestion that motivational interviewing with abooster call might be more effective than written advicefor adults in outpatient settings would be strengthenedby a trial with longer follow-up (12 months or more)analysed on an intention-to-treat basis. Furtherresearch is necessary. There appears to be no ongoingresearch investigating interventions for drug misuse inoutpatient settings.
Interventions for both alcohol and drug misuse
The evidence on interventions to address both alcoholand drug problems in outpatient settings is limited toone trial [24], which showed an impact on ongoingdrug use but not on cessation of risky drinking. Morestudies evaluating this intervention are needed, andtherefore it is not yet possible to draw conclusions onthe effectiveness of interventions for both alcohol anddrug use in this setting with adults or young people.Further research is needed to consider the effectivenessof combined interventions for alcohol and drug misuseacross in outpatient settings, particularly as we did notidentify any ongoing research investigating interven-tions for both alcohol and drug misuse in this setting.
Interventions for drugs alone and drugs in additionto alcohol appear to be very under-researched areas,and there is a need for much more practical ground-work in terms of identifying likely areas whereapproaching these groups may be feasible and researchachievable.
Poor reporting of methodology, including randomi-sation and allocation concealment procedures, is acommon problem across the clinical trial literature[31]. Follow-up was too short (<12 months) in threestudies reviewed here [21,23,24], making it difficult to
Outpatient alcohol and drug interventions 9
© 2013 Australasian Professional Society on Alcohol and other Drugs
determine long-term effects. The lack of detail andclarity regarding the actual content of interventions,duration, delivery mode and personnel delivering thetreatment was challenging. Additionally, it was oftenunclear on what theoretical framework the interven-tions were based or the behavioural techniques actuallyused. Related to this is the reporting of interventionfidelity, crucial for complex interventions. Adherence toan intervention delivery protocol can influence effec-tiveness [32–36]. Ensuring fidelity can reduce the riskof erroneous conclusions such as concluding that theintervention is ineffective, when in fact it was not imple-mented correctly [37,38]. Across this review, reportingwas mixed.
In addition, where studies appeared to have used thesame type of intervention (e.g. motivational interview-ing), the interpretation of that intervention can be verydifferent. Even where core principles are used, differ-ences may occur in the delivery of the intervention(timing, duration, intensity and interventionist),although often it was difficult to tell differences andsimilarities due to lack of reported detail.
The range of outcomes investigated in the includedstudies demonstrates the variety of measures for alcoholconsumption currently utilised, and it would be benefi-cial to reach consensus on the most useful measures.Additionally, various authors have highlighted the issueof assessment reactivity [39,40], a feature that shouldnot be ignored and given due consideration in studydesign and analysis. In outpatient settings, where mostare not actively seeking treatment for their alcohol con-sumption, and additional health problems may be con-tributing to their reason for attendance, identificationand recruitment of research participants may be a likelyproblem and one where screening and assessment canplay an important part.
Future studies should bear in mind the quality issueshighlighted in the review of the current evidence. Inaddition, the theoretical framework on which the inter-ventions are based, as well as the behaviour changemechanisms underpinning them, should be reported.Attention is also required regarding who should deliverthe intervention, mode of delivery, level of patientcontact and intervention intensity. It would be of inter-est in future to investigate the effect on outcomes otherthan alcohol or drug consumption (e.g. injury rates andcriminal offences). Studies exploring how particularsubgroups respond differently to the intervention (e.g.women and dependent drinkers) would be worth atten-tion, as would the impact of interventions on socialhealth inequalities. Practitioners may want to give someconsideration to particular initiatives aimed at areaswhere there are high levels of specific alcohol problems(e.g. injuries). Researching implementation schemesthat deliver interventions in such areas and that are
geared towards local needs may prove highly interest-ing. In addition, with none of the included studiesincorporating a cost-effectiveness analysis, morethought needs to be given to this aspect of alcohol/drugmisuse prevention interventions in outpatient settings.
Strengths and weakness of this review
This review was conducted according to national guid-ance [14]. Searches included electronic and printsources and of grey literature. As interventions foralcohol and drug misuse are an active area of primaryresearch, authors of ongoing and unpublished studieswere contacted, and details of these are included. Studyselection, data extraction and quality assessment wereconducted by more than one reviewer with disagree-ments resolved by consensus or referral to the projectteam. Therefore, our results should have a low risk ofbias. Despite our best efforts, it is possible that studieshave been missed particularly those reported in lan-guages other than English.
Conclusions
Further research is needed to investigate interventionsfor alcohol and drug misuse in outpatient settings. Thetype of intervention(s) needed to reduce consumptionof alcohol and/or drugs for different groups of patientsin diverse hospital settings is still to be determined.
Acknowledgements
We acknowledge funding from National Institutefor Health Research Collaboration for Leadership inApplied Health Research and Care (NIHR CLAHRC)for Leeds, York and Bradford, which is a partnershipbetween the NHS, social care and academia.The viewsand opinions expressed in this paper are those of theauthors and not necessarily those of the NationalHealth Service, the National Institute for HealthResearch or the Department of Health.
Other contributions
We acknowledge, with thanks, the trialists who gaveadditional information on ongoing or completed trials.We are grateful to Alexis Llewellyn for help with dataextraction.
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Supporting information
Additional Supporting Information may be foundin the online version of this article at the publisher’sweb-site:
Appendix S1 Full search strategies on Alcohol Abuseand Alcoholism.
12 J. M. Watson et al.
© 2013 Australasian Professional Society on Alcohol and other Drugs