.I i'.).- ((

. Course

Course

Acdviti€s

.I

.r

e code: CPT-I.I

e ritrq (lBGANIqCEEtg[f,8EI

Unlt Topic Metlmd oI lDstructions

I

Rcaction Mechanisms-lGenemlion, s0uctur€,stability and reactiviryof carbocations, caoanions, carbon freeradicals, carbenes, nitrenes, nitrog€n,phosphorus and sulfur ylides. Nitril€ oxid€sand nitrile imines. ceneration and r€activiryof sinsl€l and triplet oxygen. Classificationof reaciions and mechanisms.Thernodynamic and kinetic requirements,kinerio and thermodynamic conrrcl,Hammond postulate, Curtin-Hammenprinciple. Potenaial ener$/ diagrams,transition states and interm€diates

Black board, PPT, Video,Discussion

08

Aromatioiry. Huckel's rule of Ammaticity.Aromaiic sysiems with electron numb€rsother than six (including azulene, tropon€,tropolone and annulenes). Antiarcmaticity.Aromaticity in benzenoids, meso-ioniccompounds. Homo-aroinaticity.Acids and bas€s: Hard and soft aci& andbas€s. Effect of sbucture on the strcngths of

08

Assignm€nt prepa.ation on different topios by each student.

Preparation ofPPT for presentation in the olass.

Pr€s€ntation by shrd€ntr on ditrerent topics during th€ semesr€r.

Discussions on various curent scientific affairc.

Unit Toplc Method of Inqrructlons

i'.).-

II

Reaction Mecbanlsms-IlEffect of structue on reactivity: Resonance,field eff€cts a.nd steric effeots. The Hammettequation and linear free energy r€larionship,substiiuent and reastion constants. Taftequation. Nucl€ophilic sLrbstilution reactionat a saturated carbon: SNl, SN2, SN2i,SNli, SNi and SET reaotion mechanhms.Eff€ct of substraie struoturq aftackingnucl€ophilg leaving grqup. Ambidentnucleophiles and subshates.

Blacktoal4 PPT, Vid€o,Disoussion

1\

08

((

PoS and R I

TumkTumal

trgrn-nWf!Ci:itNLc unem

r UniversityLru " s?2 103.

ffi

Methods

labeling,

determining mechanisms: Brsedof produots, dererminationof interm€diates, isoiopic

hotope effects, cross overand fiom ster€o ohemical

and stereochemistry ofr, E2, Elcb m€chanism, cis-Hoffmarn and Saytzetr

competition beh{e€nand substitution, Chuga€v

Method of Instructions

Fischef,

Optical i

R-S and

Sawhorse and flyingprojestions and their

: El€ments of s)4rmetry. D-L conventions. CIP rul€s,

conventions. Chirality inwith a ster€ogenic centre,

alkylidene cycloalkanes,and spimnes (wilh 3

axis). Cmm's and Prelog'srules

Black boad, PPT, Video,Discussion

analysis: Conformationalcycloalkanes, cyclobutan€,cychexane (nonosubslitut€d

iso-propyl, tert"butyl and di-cyclohexan€s e.g., dialkyl,

and cycloheptane. Effect of

Activiti€s

Activitiss

on on different topics by €ach student.

Preparation ofPPT presentation in the class.

on differcnt topios during rhe semester.

cunent soientific affairc.

on diflerent topios by €ach student.

Pr€paration ofPPT Presentation in the class.

Presentation by on differ€nt topics during the sem€ster.

Discussions onv current sci€naifi c affaks.

Unit Topic Method

Instructl

of No.

IV

Stereochemistry-IlNomenclature and confomations of tused rings and bridged ring sysiems.Prochirality: Enantiotopic and diastereolopic aioms, groups and fac€s

Ster€$pecific and Sr€reoselective Synthesis: Regiospec;fic, R€gios€lective and

Enaniioseleotive synthesis.St€reochemistry of nucleophilic substitution reaciions: SNI and SN2 reactions,

€limination reaotionsr anti elimination, syn elimination, and stereoelectronio

factors and addition reaotions and influence of Markovnikov Ori€ntation onsl€reochemioal studies

BlaokPPT,Discussic

08

Stereoselectivity in cyclic oompounds, enantio-selectivity, diasier€o-sel€ctivity,enatiomeric and diastereomeric €xcess, stereoselective aldol r€actions

Asymmetric synthesis, use of chiral auxiliaries, chiral reagents and catalysts,

as)'mmetrio hydrogenarion! asymnetric €poxidation and asymmelric

do 06

Ster€ochernistry of six nembered rings. Determination of slereooh€mistry

orsanic comDounds us;ns NMR

02

Assignm€nt preparation on different topics by each student.

Preparation of PPT for presentation in the class.

Pr€s€ntation by students on diflerent topics during the semester'

Discussions on various ourrcnt scientific affaks

code: CPT-r.2

tirle: lllltsliAL--Ld.gly!!.MEJ-JUnit Topic Method of Instructions N

:ded

I

Chetnical Bonding:.VSEPR model, shapes of molecules-ClF3,ICl4-, TeFs-, I3-, TeCl62-, XeF6, SbCl63-,IF7, ReF7, XeF82-, TaF83-; Bent rul€s 3nd

energetics of hybridiza on;elecrronegativity and partial ionic characler;Bonds- Multioenter, Syn€rgic and Agosticbonding

Black board, PPT, Vid€o,Discussion

06

Lattic€ energy: Bom-Lande equaiion,Kapusiinskii equation; polariz bil;ly andparlial covalent oharaotet radius-ratio rules,structures of simpl€ solids, Zintl-isoeleotronic relationship in solids.Molecular orb;tal th€ory: LcAo and MOdiagrams of heteronuclear diatomic (CO,NO, HF, ICI) and tdatomic molecules (CO2and No2-).

do 10

Assignment prepar"tion on different topics by e3ch student.

Prcparation of PPT for presentation in the class.

Presentaiion by stsrdents on different topics during the semesier.

Discussions on various ourrent scientific affairs.

Jliil:l

4nifi-nn.j i. in Orgsrlic

ELh,sii'

Course

Activlties

of main group elements-and bonding in boranes,

m€tallocarboranes, Wade'sborazines, phosphazenes, S, N-


Cl6sification, structures,rcprac€men! pyroxenes,

and vitreous silicaies, zeolites and

concept I Basis o I H S A B corcepl. acid-base srrengti.

and softness, symbiosis, applications of HSAB; Acid- base concept in non"aqueous media, reactions in

anhydrous H2SO4, CH3COOH, Isopoly andacids of W, Mo and V; preparations, properties,

Black board, PPT,Video, Discussion

ty, optioal activity- CD, ORD, Cotton efec!, absolu!€ofmetal complexes. ma$€tic circular dictuoism

No. classes

anide series: Review on electronicoxidation states, spectral and

io properties, Ianthanide contracrion,and extraoiion. Lanthanid€s as

rengenis. Separation of lanthanides:exlraclion and ion-excha.ge.properties of compounds ofin II, II, and IV oxidation states


Review on Eleotronic siructurein the p€riodic table, oxidation

ocouffenc€ and syntles;s of theSpectral and magnetic properlies

of actinides in

on on different topics by each studenl.

for presentation in the class.

sludents on differeni topica during th€ s€mester.

various current sci€ntifio affairs.

on on different iopics by each studeni.

Pfeparation of for presentation in the class.

students on differ€nt topics during the semest€r.

adous cunent sci€ntifio affairs.Discugsions

- Activiti€s

.P

.I

Course til

Acttvlties

.I

with those of lanthanides and d-blockelements. Trans actinides Chemisrry ofTrans -uranium elements

Assignment pr€pamtion on diff€rent topics by each sludent.

Preparation ofPPT for presentation in the slass.

Prcsentalion by students on ditrer€nl topics during the semester.

Disoussions on various curent soi€nrific affairs.

code: CPT-1.3

Unit Topic Method of Instructions No

I

Concepts of entropy and fr€e energy:Entropy as measure of randomness andunavailable €nergy. Eniropy chang€s inreversible and irreversibl€ process andduring various proc€sses. Variation ofenaopy with T and P. Helnholtz and Gibbsfree energies. Thernodynemio orir€ria ofequilibrium and spontaneity. Varialion offree energy with temperature and p€ssure.Maxwell's r€lations, Von't Hoffs reactionisotherm and isoohore, Gibbs-Helmholtz€quation. Determination of free energychang€s. Nemst heat iheor€m and third iawof th€rmodynamics- calculation of absoluteentropies and rcsidual €ntropy.

Black board, PPT, Video,Disoussion

l0

Partiel molaf Properii€s: Physical

significan€€, Partial molar volume and

partial molar frce enersy (chernical

poteniial). Determination of partial molarquantities by intercept method and slope

methods. Physical significance of chemicalpotential. Variation of chem;cal potential

lvith temperaturc and pressure.

Formulation of rhe Gibbs Duhem equation.

Derivation of Duhem- Margules €quation).

06

Assignm€nt preparation on different topics by ea€h studeni.

Preparation oIPPT lbr prcsentation in the class. ): !Presenlation by students on different topics during th€ semester.

Discussions on various €urrcnt scientific affairs.

'- qFDhJAtJ idftst.di/

, .j..,i

Unit Topic Method of Instructions

II

auan

Heis€

LaplaEigenfirncti

for pr

'v2

L'- Cheni"trla A bdef rcview ofadicl€ dualit and

berguncertainty principl€ Concept

'ators (operator-ope|and): alg€bra ofcommutanve ano

tative operators, linear op€rator,

ian operator. Hamiltonian operator.

value. eisen tunction, well behaved

n, Hermitian operalor and its

:€ristics. Schrodingef wave equation

ricles. Wave funciion: significance ofi W*. Postulat€s of quantum

Blaok board, PPT, Video,Discussion

08

of D(

oscil

ation of Schrodinger €quation to a

e trapped in a potential field (on€

rion and ihree dimensions). Concept

1€nemcy. wave equation lbr H atom;

tion and solution of R, O and e

rns (Rigorous ireatment not rcquired),

and angulat distributions, quantum

)rs. Application of Schrodinger

on to rigid tol,or and simple harmonic

08

]aration on differ€nt topics by each stud€nt

PT for presentation in ihe class

siud€nts on different top;cs during tbe s€mesier.

r'arious cunent scientific affairs.

Activitios

ActMties

Unit Topic Method of INtructions Nr

IIt

A, Macroscopic and microscopiokinetics, Rev;ew oftheories of reaction rate-Collision theory and Transition state theory,Compadson of collision theory wilhtransition stale theory, Arrhenius equation-characteristics, Significanc€ of energy ofaotivation, Temperature co€ffioient and its€valuation. Themodynamical fornulationof reaction rates (Wyne-jones and Eyringtreatunent), Reaction between ions insolutions Influence of ionic strength onreaci;on rates (primary and s€condary salteffects),B. Concep! of Steady state kinetics,Chain reaction$-chain l€ngih and chaiiinhibition,comparison olphotochenical andthermal r€actions, Mechanisms of thermaland photooh€mical reactions betweenhydrcgen-bromine and hydrogen-chlorine.Comparative study of thennal andphotochemical hydrogen-halogenreaclions.Pyrolysis of acetaldehyde,Decomposition of ethane

Blaok board, PPT, Video,Disoussion

t2

C. Kinetics of fasi reactions-Inrroduction, Study of reactions byrelaxation n€thod (Temperatureandpressure jump)! flow rnethod (Plus flowmethod and Stopped flow method), Flashpbotolysis and Shock iube melhod

04

Assignment prcpantion on different topics by each stud€nt.

Preparation ofPPT for presentation in the class.

Pres€ntation by students on differ€nt topios during the semester.

Discussions on various ouneni scientific affairs.

Unit Topic Method

Instructtonl

No,

Iv

Chemical Dynamics-IID. Kinetics of homogeneous catatysis-kinetics of auio catatyticreactions, kinetics of aoid-base catalyzed rcaotions. Comparison ofenzyme catalyz€d and chemioal catalyz€d reactions, Mechanism (Lockand Key tl€orr, Kin€tics of enzyme catalyzed reactions - Henri-Moha€lis- Ment€n mecha.ism,Significance ol Micha€lis-Mentenconslant, LineweaveFBurk plot. Effect of enzyme ooncenrradon, pH,Temperature,Activatorsand Inhibitors on enzymeactiviry

Blaok bcPPT, ViDiscussion

l0

Course code: SPT-I

Cours€ titl€:

Activiti€,s

Discussions

on on different iopics by each student.

forpresentation in the class.

sludents on differeni topics during the semester.

various cunent soientific affairs.

on different topics by €ach sruden!.


students on different topics durjng the sem€sier.

various current sci€niific affairs.

Th€ories of uni-rnol€cular reacrionsr l-indemann theonand H;nshelwood theory.

Surface r€aclions-Uninoleoular and biomolecular surface: mechanism, inhibiiion and activation energy

of Medicinal Chemisiry:tenninolo$, in med;cinal

stry, Drug, Pharmacy, Pbannaceutics,

, Phamacodynamics agents,)ophore, pharmacodynamics,ites and anri-m€tabolites,

of chemothempeutic actionsr 1)defenses. 2) Chemical defens$.

Suface active agenls; b) MetabolicAssay of Drugs: Chemical

, Biological Assay, Immunological, LD50, ED50,lC50 and ID50

Black board, PPT, Video,

and nomenclature of Drugsof drugs on the bas;s of

c aotion. Nomenclatur€ of Drugs.between drugs and medicines

Method ot Instnctions

Classifi cation, r€actions olsugars; Oxidation, rcduotion,

ation with phenyl hydtazine,of alkalis, action olacids, formation

fonnation of €olored pfoducts.of suga$ in foods - Browning

(non-enzymioDrug Discov€ry

Procedure followed in Druga) Drug Discovery without a lead

Discovery. Lead Modification:Design and Development

of active oarc Th€

Black board, PPT, Video,Dhcussion

^-.tL9Or "1.;i,.,.1,..,.

'frJr$z'

Activities

.I

Activities

Assignnent preparation on diflerent topics by e&ch student.

kepa.ation ofPPT for presentation in the class.

Presentation by students on differ€nt topics durirg the semester.

Discussions on vadous curent sci€nrifio affairs.

Unia Topic Method of No.

IV

In-silico and Computer Aided Drug designIntroduotion to Moleoular Modelin& Lipinski's rule of five, Proteinprepamtion, Ligand prepantion, Molecular M€clanics, force fields(Potential energy tunolion), Energy Minimization Methods,Conformational Analysis. Concepts of Virtual Soeening, Druglikeliness, Screenins-Counting Schemes, Funotional Grcup Filters,

Black

Discussi

08

Topological Drug Class:fioation"Pharmacophore Point Filler-FocusedScreening Libraries for Lead ld€nlification, Pharmacophor€ Screening;Structurc-Based Vidual Scre€nin& Protein Structures, ComputationalProtein-Ligand Docking Techniques with the help of docking serverc,T)?es-Rigid Docking, Flexible o. induc€d fit Dookin& in sili€o De

08

Assignment preparation on differeni topics by €ach student.

Pr€paration ofPPT for presentation in the class.

Pr€sentation by students on diff€rent topics during the semester.

Disoussions on various cunert scientifio affairs.

n r^c*"'io$'' Tunrr

'htrn'@rit4

equation;

b) Funotional groupc) Stfuorur+activity

ip d) Structure modifi€ationpotency and the therapeutic

l. Homologation; 2. Chain3. Ring-chain

on; 4. Bio-isosterismModificaiion to incr€ase oral

Effect; 2) The Hamme!Lipophilicity effect.

Prodrugs ad soft drugs.gs: i) Prodrugs designing,

ii) Prodrug formalion ofcontaining various chemical

and Drug delivery systemdrugs: i) so{i dmg coceptj ii)

solt drugs

Method of Instructions

Injection,Topical,Blood,Baffi€r,TargeL

EnzymesInlroductiStudy

Kinetics,

Inev€rsibl

into the Bloodstrsm, Oral,Transdermal, Olher Roules,

Distribution: Drug Transport,Membranes, Blood-Brain

and Elimination: Drug

Drug Targets

, Definition, Shucture, Caseof a-Helices to Cross CellTypes, Mode of Action,

Single Substrate, MullipleInhib'tors, Reversible and

Pharmac€utical Concems,R€sistance to Inhibitors,Effectq Metabolism of Drugs

Black boad, PPT, V'd€o,Discussion

Enzymes,channels,Tyrosine

Th€ories,Th€ory,Resid€nce

Similarities and Differences fromLigand-Gat€d Ion

G-Prot€in{oupled Receptors,Fl-ink€d Rec€ptors, Nuclear

Types of Ligands, Agonisis,Inve$e Agonisis, Receptor

Occupancy Theorf, AllostericRate Theory, Drug-Target

on differcnt topios by €€ch srudent.

Prepantion ofPPT presentation in tle class.

on different ropics during the semester.

ouneni soientifi c afAirs.Discussions on

e coder CPT-2.1

e titre: UqBggIe.,tegEMIf,IRLlIUnit Topic Method of l6tructions

I

Metil-Ligand €quilibrla ln solution-Step-wise and ovemll formation consianrand lheir relationship, trends in step-wiseconstant, kinetic and th€rmodynamicstabiliiy of metal complexes, factorsaffecting the siability of metal complex€swith reference to the nature of the metal ionand liganq chelate effect, macrooyoliceff€ct and their thermodynanic origin.Deternination of binary formation const3ntby pH mety, specaophotomehf,polarography and ion exchange methods


12

Structure and bonding-Structure and bonding in hydride,dihydmgen, dioxygen, isocyanide, CO, NO,N2 and ieriiary phosphine complexes of

04

Assignm€nt preperation on different topics by €aoh student.Prepararion ofPPT for prcs€ntation in the class.Presentation by students on different topios during th€ semester.Discussions on various ounent scienlific affairs.

Unit Topic Method of Instructions I

I

M€tal-ligand bondlng-Siereoisomer'sm' coordination numbers 3 to8. Crystal field theory, sali€nt featurcs,spechoch€mical series, splilting of d-orbitals in tetragonal, squar€ planar,trigonal-bipyramidal and square-pyramidalg€ometry, applications of CFT- colors oftransition metal complexes! magnetiopropenies of octahedral compl€x, distortionof octahedral complex,

Blaok board, PPT, Video,Discussion

08

CFSE and th€ir user, factors aff€ciingCFSE, limitations of CFT, experimentalevidence for metal-ligand coval€nt bondingin complexes, nephelauxetic effect LigandField Theory, MO theory: tetrahedml andoclahedral oomplexes (inoluding r-bonding), angular overlap nodel.Siereochemical non-rigidity, self-ass€mblyin supramol€cular ohemistry

08

Assignment prepamtion on differcnt top;cs by each siudenl.Preparation ofPPT for presentation in the class.Presentation by studenls on different iopics during the semest€r.Discussions on various curent soientific affairs.

ric snectra or coordtntionnos- spectroscopic ground shr€s!n rules, term symboti for dn ions:

Parameters, Orget, CorclatioD and

glact loard. pptvideq

€ of ld metar-aqua compteG; ofrr v,,Lr- drvalent Mn, Co and Ni,. calculation of Dq. e ana rjters. CT specka. Specimt propertiei

ariae ana ect;"ia" metal

".::^::l]f ,'.":11111r-,j' ".J- ""* ",'**:j:::,1,::Tl^11i r! derermrnatron_ couy, Fa,{u,y.?:T^lcj:tlc co"*crrgn,

""rr,"r """i"ir",r"-""iir"ljli'rlli:l*:l,l ::T1T,ej:"" "ouprine. spin_ crosso;er. Magtre,ic

de ana Actiniue metaicoiptlxes

reacrions of rrunririon rn"rut, "o.pt"*"r,

gush--

::::: o"'n"-: rule. quantum yierd. Jabronski orasmms,)n reaction". photo-redox remlions, liga'd Onr..*;;":;;;version

Mettrodorrnstructions-

Relation between fugaciry andelerminalion of fugacity ofgases.

of fugacity wirh telnp.,i*uri *a\ctivity and acriviry coefficients.

activity with tempemture andD€termination of activiry

by el€ctrical merhods

gtact boardJpT, Videq

curent scientifi c afai|s.

'tron on different topics by each student.

ror presentation in lhe ctass.on dilTerent bpics during the semesrer.

Acttvides

Discussions on

Coursr code: CpT-2.2

Coursetitle:

Lt,on on difl€renr ropics by ea€h studenr.rcr p.es€ntation in the class.

ts on different topics during the semester.curcnr soieniifi c affai.s.

t "$"*tuqTi:t''t., .005

.D

Unit Topic -----

Electroctemktry-I

:,leclro:hemisry of soturions: tonic arrnosphere. Deb)e_Hucket

ll5,?"".., T:. probrem of acriviry coefficienL Debye_Huckel

1",,,,",9 .,,*: ueDye_Huckel equarion tor appreciabteconcentratron. Drbye-Hucker onsagei conducrr nle equarron anorB exrensron Lo ron soh€nF jnterarions, Deble-Huck;t Bjenummooe. ron associarion. Lripte ions, rripte io; and cond;cbnce

H

Method

III

Biack boa.Video, Dis,

do

t0

:*i:"r'ir tTa" ;\ efi ;;;: #;:: .;;:.';"lT:*,:1,;ff

n:l^.":i: -:,

*,rT: excess. rhe merhod of dererminalj;n andT::y.:,'.:* "f inreriac'at rension as a funcrjon of appriedpolen.rat djfterenc€ across the intedee

do 06

Ass,gnment prepararion on differ€nt ropics by each stuoeniPreparation ofppT for presentation in the ctass.

Presentation by srudents on different topics during the semester.Disoussions on various cun€nt scientific affairs.

Unit TopicMcthod of Instructto; No.

Iv

Approxima0e methods -Necessiry ofapproxrmare methods, perurbation methodir||5r order and s€cond ordef €orections fol\lave tuncrions and energies, apolication ror,e - atom (first order conecti;r ontv, _oalcxlarion of first jontzation porenrial ;ndornorng energ)l. Vadation rheorem"$ar€m€nt and proof. Application ofvarralon rheorem to a pafiicte in onecrmensronat box. H and He _.roms

che-rcar fitr"g '"

d raro.ii":c-,r."il)ond-vaten€€ bond and motecular orbid I

'pproaches wirh comparison. Secular Iquarrons and secutar dercrminants. I,lorecutar orbiral theory apptied to Iomonuctear and heteronuolear diaiomic Iroreclres. Introdudion roHucket motecuiar IrDrrarrheory ofconjugated systems and trs

I

Blmk board, pFl Viaeo,Discussion

08

08

Assignnenr pr€paration on diff€rent iopics by each stud€nr.Preparation ofppT for Fesenration in the class.Presenhtion by srLrdents on differcnr topics during lhe semester.Discussions on various cunenr scieniific affairs.

os of dilute solutions:, Henry's law. Ideal and non-

. Discussion andio derivation of the laws of

pr€ssurq clloscopy ard. Detemination of molecular

of chemical potentials

Phase

simple

involving

Systems

Studies: Tlrermodynamicof phas€ rulej application ofto ihe two component systems:

tYPq compound tbrmaiionmelting point and

m€lting points, systemsfornation of a continuous

lid solutions. Applioation ofto three component syslems:

ihree liquids and syslems oftwo

Method of Instructlons

StatlsticalIntroducti

probabiliiyenergy,

partitionEvaluationHelmholtz

thermodlnamic probability,

principle of equipartition of-Boltzmann distr;bution

padiiion funclion and itsD€rivation of lranslational,

vibrational and electronic

of internal en€rgy, enthalpy,and Cibbs free enefgies,

constant, partition functions ofatomic molecules. Evaluationar enropies, entropy of

(Sackur- T€trode equaiion


equations -Bose-Elrst€in anddistribution €quaiions.

of solids: Einstein andcapacity equations, Debye-

lemperaturc and its

on differ€nt topios by each saudent.

Preparation ofPPT pres€ntation in the class.

on different topics dudng th€ s€mesier.

curent soi€niifi c affairc.Discussions on

Activttlcs

on different topios by each student.

Pr€paration ofPPT presentation in Ih€ class.

on diff€rent topics during the sen€ster.Prcsentation by

Dhcussions on cunent scientifi c affairs.

Qos

Activities

codq SPT-2.3 A

titlq ORGANIUnit Topic M€thod of lnstructions

I

Arometic Substitution ReactionsElectrophilic Substitutton R€actionsr Thearenium ion mechanism. Orientation andreactivity. Energy proftle diagrems. Theorlho/para €tio, ipso attaclg orientarion inother ring sysrems. Quantitative treatnent ofreactivity in subsaates and electrcphiles.Effect of leaving group. Amination,sulfonation rcactions, Diazonium coupling,Vilsmei€FHaack reaction, Gaitermanreaction, Gattermann-Koch reaotion and


10

Nucleophilic substifution reactions: TheSNAr, SNt, benzyne and SRNIm€chanisns. Reactivity: effect of subshai€structure, leaving group md attaokingnucleophile. Goldberg reaction, Buch€rerreaction, Schiemann r€action, Von Riohter

06

Assignment pr€pamtion on different topics by each student.


Prcsentation by stud€nts on difTerent topics dudng the semester.

Discussions on various cunent sci€ntific affairc.


IT

Addition ReactionsAdditiotr to cnrbon-carbon nulttpleboDds: meohanistio and srefeoch€micalaspects of addition reacdons ;nvolvingel€clrophiles, nucl€ophiles and free radicals.Regio, stereo- and chemoselectiviiy.Orientation and reactivity. Addidon tocyclopropane ring. Hydrogenation of doubleand triple bonds, hydrogenation ofaromaticrings. Addition ofalkenes and/or alkynes toaik€nes and/or alk),nes. Ene synthesis.Michael r€action


08

Additior to carbon-heteroatom nulttplebonds: M€chan;sm of metal hydrid€reduction (NaH, LiH, LiAlH4, NaBH4) ofsaturaied and unsatu.ated carbonylcompounds, acids, esters and nitdles.Addition of Gignard reagents andorganolithium reaaenis to carbonylcompounds and unsaturated carbonylcompounds. Conversion of aldehydes tonitr;les. Hydrolysis of nitril€s and add;tionof amine,s to isocyanates. Formation ofxanthates. Wittig rcaotion. Addition ofamines, alcohols, water, NaHSO4

do 08

. ,., Dr,.or*'):.,

",.,r;s,l'-.

on on different topics by €aoh srudent.

Preparadon ofppT

Activlties

on differ€nt topics by e3ch sludert.

. Pr€paration ofPPT for ion in ihe class.

on different topics dur ing the semester.

presentarion in the ctass.

on different topics during tle sem€s!€r.

Discussions on ounent scientifi c affairs.

Assignment pr€pamti on diff€rent topics by each student.

Preparation ofPPT presentation in the class.

Presentation by stu on differcni topics during the semesrer.

Discussions on cunent soientinc affairs.

Activltles

Orgsnic

of theDarzen

SmithSharyl€ss

M€chanisms and synthetic usesowing: Stobbe condensation,

on, Cdnizaro reacrion,reaction, BenzoinClaisen- Schmidt

Claisen r€aclion, Simon-on, Stark Enamine rea€tions,

on, Mirsunobu reactiorr,annularion, Dieokmann

and Mannich reaction, Van-Heck reaction, Suzuki

M€thod of Instructions

Lanisms and synthetic uses of the folowingiin, Pinacol- Pinacolone, Fri€s, Wolff.

. Cunius, Lossen and SchmidtBenzil-benzilio acid rearang€ment, Amdr-

Tiffeneau-Demianov rcacrion,

Black board, PPT,Video, Discussion

g-wiechell r€arrang€menr. St"'€ns. wtftrg,Dienone-phenol, Bak€r-

Baey€r-V;lliger oxidation, NeberBenzidine rearangement and allylic

scientific affairs. .:8.ryS#*ilan-eos"iii",l,,i,',- ,',

{vmlr*" '

Activities

code OEPT-2.4

title: CHEMIfUnil Topic Method of Instructions

Food Classification, Chemical compositionand nutriiional value of oommon food stuffs,

Food preservation and processing: Fooddeterioration, nethods of preservation and

Focessing by heat, col4 chill storage, deepfrcezirg, drying, concentration,fermentation and radiation

Black board, PPT, Video, t2

Food quality: Sensory evaluation, objectivemethods, non-nutdtonal constituents andfood salery

do 04

Assignmenl preparaiion on different topics by each siudent.

Prepdation ofPPT for presentation in theclass.

Pr€s€ntaiion by students on differen! topics during th€ s€mester.

Discussions on various curr€nt scientific aflairs.

Unit Topic Method of Instructlons

Food additives properties & usesl

olassification of food addidves,

Anrioxidants (Ascorbic acid, Citdc acid,

Tocopherols, Butylated hydroxyl anisole

(BHA), Terriary butyl hydro quin:n€,

colournrg egenrs (Chlorophyll, Caramel,

Curcumin or tumeric, Indigo €armine),

flavours (Diacetyl, Vanilla exlracts,

Vanillin, Ethyl vanillin), emulsifiers(M€thyl cellulose, Carboxymethyl

€€llulose, cellan gum),.


08

Artificial sweeteners (Aspartame,Acesulfarne K, Sucralose), Ieavening agents(BaHng powder, Ammonium bi-carbonate,Ammonium carbonate), thickene$ (Alginicacid and their salts) and pr$err'aliv€s(So$ic acid and its sodium, potassium andcalcium salts, Benzoic acid).

08

Assignment preparation on different topios by esch siudent.

Prcpamtion ofPPT for presentation in the class.

Pr€sentation by students on d;ffercnt topics during lhe semester.

Dis€ussions on various curent sciertifio affai|s.

Unit Topic Method oflnstrucfions

III

Pigmer

myoglc

s and colou$: Impo,iance &on or color in foods, Chlorophylls,)rn and haemogtobin, ethocyanins,os, rannins, beratains, quinones.

bracK ooafdJ ppT. Video.Discussion

08

ids properties & uds. Chemicalor pigments in foods: extmction,

semi-purification and

08

Ltion on differeni lopics by each student.

ror presenration in lhe ctass.

lents on dif?erenr ropics dur.ing rhe semesref.

Activiii

cufl€nt scientifi c affai$.

Unit Topic Method of No.

IV

Ioss durinr,qr.i r.o!'u'.ru Inrurb rcqurrcrnen|5. drs(rrbL{.on :n tood\,

proc€5srng. enec15 ol-de]lciency ana characrc.isl:c prupcrres'tJ|l tr.amrml! BZRiboUavinr. BJ (pan.olhenicacidr. Bo

,, bL2 (Lyanocobatamin).1K,uu). (

,(ascorbic ac;d). A rRelinot). D rc;tciferot/. Cr. K rn.phfl.oquinone). fot:c acid (pcA) and N;ac,r.

Black boad,PPT, Video,Discussion

i0

H(Biotin),06

Prepamtion ofPpT

)n on differcnrtopics by each sludent.

I presentation in the ctass.

rls on different topics during the senester.

s cufl ent scienrifi c affairs.

Course codo: Cr

Course title:MECHA NTSMS

Activities

.P

codo: CPT-3.r

titlg BEACIION MECTIANISMS. PERICVCTTC REAcTToNs AND

Unlt Topic M€tbod oI lNtructtons

I

Aliphatic nucleophilic and electrophilicsubstitution reactlonsNucl€ophilic subst;tution r€aciions:Substitulion at allylic carbon (allylicrearmnsem€nt), trigonal carbon(hydrolysis of esters and amides, use ofDCC in th€ formation of anhydrid€s),vinylic oarbon. Neighboring grouppariicipation and SNi reactions.

Black board, PPT, Video,Dhcussion

08

[l€ctrophilic aubstitution teactions: SE2,SEI and SEi mechanisms. Hydrogenexchange, migration of double bonds, o-halogenation of aldehydes, ketones andacids. Aliphatic diazonium coupling,nitrosaiion ar carbon bearing acdvehydrogens, diazo transfef reaction, carbeneand nitrene inserlion, decarboxylation ofaiiphatic acids, haloform reaotion, Hauef-

08

Assignment preparation on different topics by each student.

Pr€paration ofPPT for presentadon in the class.

Pres€ntation by stud€nts on difiercnr topics dudng the semester.

Discussions on vadous our|enr scientifio affairs.

Unit Topic Method of lNtructiotrs

ceded

II

Free-rrdical chemistryGeneration of free-radicalsr Thermalhomolysis of peroxides, per-est€rs and azocompounds, phoiochemical nethods. Fr€€radical reaction$ Free-radical meohanismsin general. Free- radical substitutionm€chanisms. M€chanisms at an aromatiosubstate. Neigbbodng group assistance infree-radical reactions. R€activity foraliphatic substrates, reactivity ai abridgehead, r€€ctivity in aromariosubstraies, reactivily in the attacking mdical

Black board, PPT, Vid€o,Disoussion

08

:)a: '"

- *1, t'tttd-F')'r'.y..,.,i. 'ji ri' ' :

-j;

Activities

at an alkyl oarbon and ancarbon, hydroxylation at an aliphatic

hydroxylation at an a.omaticoxidarion of aldehydes to carboxylicformation of hydrcperoxides and

. Comberg-Bachmam reaction,dylation, Kolbe reaction and

PMO

and t

+,nJ

on of pericyclic reactions,

orbiral symmetry, Woodward-conelation diagGns. FMO and

apprcaches. Fronti€r orbhals of1,3-buiadiene, 1,3,5-hexatrien6

reactions: co olatory andmolions, 4n, 4n+2 and allyl

. Cycloaddilions: The frontier orbitalof cycloadditions, [2+2] [3+2]

2l cycloadditions, analysis by FMOconelation diaSram meihod.

and suprafacial additions, Lms["ms + inJ-oyc]oadditions. [d2r +

["4 + o2J- ch€letropic reactions,


enantio and Endo s€l€ctivities inder reactions. Rerro Diels-Alder. Sigmatropic rcarmngements:

Orbital descripiion,and antarafacial shifts of H,

shifis involving carbon

[,:, jl- sigmalropio reanangementsWalb , Cope, oxy and aza-Cope

on d:fferent iopics by each student.

Prepamtion of for presentation in the class.

on diferent topics dudng the sem€st€r.

ous currcnt scientific affairs.

oos -,*, i')lla"-.1{Tunlkur Uiriverslty

Tumakuru.572 1 03,

-\ course

Course

Activities

Assignment prepantion on different topics by each srudent.


Pres€ntation by students on different lopics during the semest€r.

Discussions on various cunent scientific affairs.

Unit Topic M€tho

Instru

of

IV

Blochemlcal m€chanisms

lntroduction. Them€chanislic role of the following in living sysi€ms.1. Thiamine pyrophosphate (TPP) in decarboxylation of kero-acids and in

the formation of- ketols,2. Pyridoxal phosphate (PLP) ;n lransaninarion, decarboxylation,

dealdolisation and elimination r€actions ofamino acids.3. Lipoic aoid in the transfer ofacyl grcup r€actions

BlackPPT,Discus

Videq06

1. coenzyme(CoAsH) inthe transler of acylgroup.

2. Biotin3. Vitamin KH, coenzyme in carboxylarion reactions.

04

1. Tetrahydrofoli€ acid (HaF) in one- carbon tmnsf€r reactions,2. Vitamin Br, €oenzynes in molecular rean€ngement reactions and in th€

synthesis of meihionine and m€thane.

3. Nicotinanide and Flavin coenzymes in bioloeical redox reaotions

06

Assignment geparation on diff€rent topics by each sludent.

Pr€paration ofPPT for presentation in th€ class.

Pres€ntatior by studenis on different topics during the s€m€si€r.


code: CPTi,2

ftle EEEMISLRY OF NATURAL PRODUCTS

Untt Topic Method of lnstructions

)eded

r\A{

I

Terpenoids and CarotenoidsClassification, nomenolalurej occurrcnce

and isolation. Isoprene rul€s.

Ster€ochemistry of citral, famesol,limonene, I,s-cineole, menthols andborneols. Conelation of configurations oft€ryenoids.

Siructure elucidation of oamph€ne,

G)pinene, G)caryophyllene, and

C)santonin.


06

:l!

SynthLinalool

Methods

and biosynthesis of the followingland C)terpineol. Commercialof camphor. Biosynth€sis of

cyclisation of squalene into Cand friedelene. Carorenoids I

isolation. Structural relationshipP- and y-carctenes. Siucrure

and synthesis of p-carotene

Method of lnstructioos

elucidation and synthesis of theids: Ephedrine, Cinchonin€


Nomenclature, basic sk€leton,

bon and stereochemistry.structurc and structuralof stercls and bile acids

on of ring size, nature of side

of angular methyl and

ofrinsjul)ctions).

on different top;cs by each student.

presentation in ihe class.

on diflerent topics du ng the s€nest€r.

curenl sci€ntifi c affa;rc.Discussions on

Activities

on different topics by each studenr.

Preparaiion ofPPT Presentation in lhe class.

on diff€rent topics during the semester.

current scientifi c affairs.(

.I

Unit Topic Metho(

Instruc

No.

III

Porphyrins and vitamin BfStructure elucidation and synthesis ofha€min,

chlorophyll-a and vitamin-Br, (synthesis ofVitanin-BD from cobyr;cacid).

BIaokPPT,Discl

06

Nuclelc acids

Introduction, components of nucleic acids, nucleosid€s,nucleotides and oligonucleotides. Stfucrure elucidation andsynthesis of nucleosides and nucieotides.

Chemical synthesis of oligo'nucieotides: Pmtecting groups for hydroxygroup in sugar, amino group in the base and phosphate functions.Methods of formation of inter nuoleoride bonds: DCC, phosphodiesterapproach, phosphotriester apprcaoh, phosphfte triesrer andphosphoramidite methods. Solid-phase synrh€sis olotisonucteotides

l0

Assignm€nt preparaiion on different topics by each student.

Preparation of PPT for prcsentalion in the olass.

Pres€ntation by students on difTer€nt topios during rhe semester.

Dhcussions on various cunent scientifio affahs.


ry

ProstaghndinsIntroduotion, nom€nclature, classificationand biological role ol Fostaglandins.Structu€ eiucidation and stereochemistry ofPGEI, PGE, and PGE3.

Synihesis ofPGEr and PGE, by Corey's andStork's approaohes. Synthesis of PGE3 byUpjohn's approach.

Synthesis of prostacyclin I, andthromboxane 8,. Bjosynthesis olprostaglandins

Black board, PPT, VideqDiscussion

l0

Introduotion, classificaton and Pheromon€sin pest oontrcl. Synth€ses of (one synthesisshould besl€reoselectivesynrhesis)

Grandisol (component of boll weevilph€romone) Bombykol (sex pheromone ofsilkworm moth).Brcvicomi! (phercmone

Ircm De ndrcit is brcriconis)

06

c .) cfii-l r l

and I in l', ,': ]'Ilrr,r'ui'"';.thc$iisuy

. ,r113-

on on differ€nt topics by each student.


on different topics during the semesl€r.

Course code: SPT-3.3 A

Activities

cumnt scientifi c affairs.

on diff€rentlopics during the semester.

Assignment on on differcnt topics by each student.

for pr€sentaiion in the class.

ous clrrent soientific affairs.

t1:. - l:,iijilry

: .,. ;: , i]

and C-N bond forning retctionsreaction, use of acetylides in c-c

reactions. Aoid-catalyzedof olenns, Prin's

Sbapirc reaction, DieckmannRobinsor annulations,

reaotion, Acyloinon and Houben-Hoesch rcaction.

synihesis, Meyef synthesis.


of nuoleophilic n;hogen and

hilic carbon (NHr, amines and

as nucleopHl€s in substitulion,

and amines in addition to k€tones

aldehydes). Electrophilic nitrcgen

nuoleophilic carbon (nitration,

ion) for the bond formation

ons (including Skraup synihes;s,

reaction, N- Ninoarcmaticrcanangement Fisher-Hepp

Japp- Kl;ngemanr reaotion).

Activitics

Unit Topic Meihod oflnst.uctions

Leeded

II

Reagents in orgrnic synth€sisUse of the following in organic synthesisand tuncrional group bnsformalions.Aluminium iio-propoxide, NBS, Lithiumdiisopropylamide (LDA), dicyclohexylcarbodim;de (DCC),dichlorodicyanoquinone (DDQ), Corcy,Chaykovsky rcagent! Raney-Nickel,diazomethane, TMS-chloride, 1,3-Dithiane(reactivity and unpolun9, PPA, Yamaguohir€agent. Woodward and Prevosrhydrcxylation. Functional grouptmnsfomations: Nitro to keto group (Nefreaction), alcohol to aldehyde


l0

Oxidation$I oxidation with cr (VI)oxidants (CrO3, &Cr,O?, PCC, PDC), Mn(\4I) oxidants (Jones reagent, MnO,,KMnoa), oso4, Seo2, Pb(OAc)4, HIo4,Ag2O, DMSO.

06

Assignment prepantion on d;fferent topics by each student.

Preparation of PPT for prcsentation in the class.

Prcsentation by students on differeni topics duing rhe semester.



)ed€d

IlI

Oxldations-IIOzone, peroxides (HrOr, r-BuOOH,dibenzoylperoxide) and peracids(Pr€pantion, properties and applicaiions ofCF3COOOH, ni-CPBA, momoperphthalicacid) as oxidizing ag€nls. Dess- Martinoxidation


06

Compl€x metal hydrides, dissolving metalr€ductions (including Bir€h,

B€nkeser, Clemmensen reductions),diimide reduction, catalytic hydrogenalion(homogeneous and heterogeneous), L€ukartreaction (reductive amination), Wolf-Kishner reduction, McMury reaction,Pummer, Willgerdot, Corey'Bakshi-Shibataand T;shchenko reactions

10

Assignment pr€paration on different ropics by each student.


Presentation by students on diff€rent topics during the semesrer.

Discussions on various cun€nt scientific affai$.

Unta Topic Method of

IV

Sterl

diasl

Dia!

hydr

metric Syrthesi!nd methods of deteminalion of'ee'.)sel€ctivity: classification, terminology and principle.

met.ic synthesis and asymmelric induorion. Double

reoselection anddoubleasymmetric induclion.

ic stereoselection: Addition ol nucleophiles to carbonyl

cunds (1,2- 1,3- and 1,4- asymmerric induotion). Asymmetriccondensation .Addition of allylmetal and allylboranes to

nylgroup.:reoseleclion in cyclic systemsr Nucleophilic addition to

ketones (formation ofa al and €quatorial aloohols, catnlytic

Senation, alkylation, diastereoselective oxidations and

setective cyclizalion of poylenes).

Black board,

Disoussion

08

(s)alpllCHIhydr

Enal

aldo

Pol)

'BMscl, t-)- EoAlcl2.lbomne, (S)-BINAL-H, (R,R)-DIOP, and (S,S)-

APHOS). Enantioselective alkylation of ketones tidzones. Enantioselective alkylation with chiml PTC.

ioselective Michael addition. Enantioselective intramoleoular

cond€nsaiion. Use of (+) and (-)-DET in asymmetric

dation.

rer-bound chiral catalysts in asymmetric induction,metric amplificalion.

do 08

Acttvtu

Course

Course

Assignment prel

Preparaiion ofP

Presentaiion by I

Discussions on \

code: OEPT-3,4

tifle: CHFMIST

ltion on different topics by e3ch stud€nt.

for presenlation in the ciass.

lents on different topics during the sen€ster.

ous cur.€nt scientific affairs.

Utrlt Topic Method of Instruotions

(,c,",-t""2- ^ oRD'r!,..iac

oo' lij';l;'.11:';: ;'l'I "oTumakr'fu - r;- ii3'

1 Acttvlttcr

Acttvttles

Black board, PPT,Discussion

Enzymes: Classificalion, speoifioity, faoiorseffecting the rate of enzym€ €atalyzedreactions, enzyme inhibitors, enzymicbrowning

enzymes in food processing -

carbohydrase, prct€ases, Iipases,

Carbohydraies: Classification, reactions ofsimpl€ sugars; Oxidation, reduction,

condensatio' with phenyl hydrazinqaction of alkalis, action of acids, formation

of esteN, formation of color€d prcducts.

Function of sugars in foods - Browning

reaction (non-enrymic).

Blaok board, PPT, Video,Disoussion

Polysaccharidesi Brief study of theoh€mistry - starch dexlrin, glycog€n,cellulose, hemicellulos€s, pectic substances,gums. swe€tness of sugars, re'atron ofstructur€ to sweetness.

Assignnent preparation on different ropics by each student.


Prcsenlation by students on different topics during the semester.

Disoussions on various cunenl soientific affairs.

Assignment prepsmtion on difer€ni topios by €aoh siudent.

PrepaBlion ofPPT for pres€nlation in the class.

Presentation by studenis on diff€rent topics dur;ng the semester.

Discussions on various curenr scientific affairs.

j r iifr |1 irl2nlc an_aii-,:,,1r i-!1i.r'rrsitY'a,rf.. rr'rr " r' I r'_

and aniro acidsr Amino acids -sb_ucrure & phlsical &

propefiies. P€ptides (Ox)rocin),of peptid€s

Black board, PPT, Vi

proteins - classification,properties of proreins,

prctein gels, prot€olyticBiological impo$ance ol proteins

'lassifica(ion. role of lipids, farr) acias andliyierot aerivea-and fats, Physical properri€s - polymoryhism

of lah. rancidily. reverslon. polymerizaLion, saponihcarion., phospholipids, lipid mehbolism.

Activities

Activitiei

Presentation by

Pres€ntation by

Discussions on

on different topics by €ach siudent.


on different topics during the senester.

Discussions on cunent soientifi c afairs.

on on different topics by each studenr.

Preparation of for presentBtion in the class.

on different topics during the seinester.

ous curent scientific affairs.

{ u--^--^e-.- or'3)i],'.iu,"'.tw

oos'i$$-1, ifi;,; ;g

Course

.t

code: CPT-4.1

tltle: ORGAI

Unit Topic Method oflnstrrctions

I

Organometrllic Compounds in OrgmicSynthesis-IChemistfy of Organo-transition metalcompl€xesr General introduction. lSand 16-Elecaon rules. Complexation and D+compl€xation Reactions: o-Bonded systemsinciuding nl Iigands. ,r"Bonded systemsinvolving dihapto to octahapto ligands suchas olefins, acetylenes, allylmoieties,butadiene, cyoloburadiene,cyolopenta, cyclohexa and cyclohepiadienylnoietieq cyclohepl4 cyclooctahi€nes, andoyclooctatetf aene moieties.Use of organo-transition metal complexes asprotecting and stabiliz;ng goups: Proteotionof olefins, acetylenes and di€nes.Stabi{ization of cyclobutadines and

Black boerd, PPT, Vide(Discussion

08

Orsano-metallics as elecaophiles andnucleophiles: Nucleophilic addition to 12,n5 ard n6 complexes. Eleclrcphilic addition10 n4, n6 and carbene complexes.Organo-metallics in coupling andcyciization r€acrions: Coupling andcyclization of organic nuoleophiles witholefins (including Heck reaciion), andcoupling of olefins with acetylenes(including Felkin's reaction).Organo-m€iallics in isom€rization,oxidation and reduction reactions:Isomerization of olefins, allylic aloohols andallylic ethers. Oxidation of ol€fins(including Wacker\ process andepoxidation), reduction of olefins and o,B-unsaturated compounds ('ncludingwilkinson's reaction).

08

Assignment prcparation on diff€rent topics by each student.

Pr€paration ofPPT for $€sertaiion in the class.

Pres€ntaiion by stud€nts on differcnt topics dudng th€ s€m€ster.

Discussions on various curr€nt sci€nrillc affairs. J i I I 'n9$ aFo i-. r- |<\ z 'llh)'J'i

ar lrnat(1!:ffi. !7:t , 1r:

alkyiUse

Use of

Simn

nilriles

tdalkyl

Compounds in Organic Synrh€sisll

'lation reactionsr Use ofdrconium conptex€s in rhes of esters, acids, aldehydes or acyl hatides f|omides. In the hydroformylation of olefi ns and dienes.iron corplexes for lhe insenion ot CO group inromolecures such as dienes. alk)l hrtides and vinylr. Use of cobalt comple"res in rh€ synihesh offrom eporides. laclones fiom a ytjc atcohots and in

palladium oomplexes for the carbonylation of alkyldienes and allenes. Applicarion of rhe

organo"merallics in organicS)nrhesis: Organo-nncsr prepar;liox,wifi compounds conraining acidic protons. reaciion

multiple bonds, trans-metallation, additionof zinc relgents with carbonyl compounds.

ilh, and Refonnatsky rcaction.s: Preparation. Deprotonation reactions,

c-addition reactions. Reactions with imin€s,d isonitriles. Organo-copper reasents: (Gilmanliihium dialkyl cuprates): Prepararion, reactions

.1. allyl. !in)1. benzyl and aryt hatides. atdehldel,(ircluding o, p'unsaruraied carbonyt compoundt)xides. organoboranes: ;som€rization reactions,, protonolysis, ca$onylarion, cyanidarion.icon compounds: Inlroducrion. geparations ano, Peterson rcaction. Organophosphorcus

: Nomenclature, synrhesis and reactions ofphospbine, ldarylphosphine, trialkyl phosphite,agnesium (Crignard reagent), organomanganese

Black board,PPT, Video,Discussion

metallic Conpoundsuorine and Organosulphur compounds:

Preparations, reactions, mechanismapplications of impotunt fluorine, sulphur

Small

thirane,

Furan,Imidaz(

Heterccycles: Synthesis,Properti$ and Reactions of three

member€d heterocycl€sr Oxirane,riding azelidines, oxetane and

leterocycles: Synih€sis,aromalic chamct€r and

of following heterocyclio rings:Thiophene. Pymzole,

thiadiazoles and oxazol€s

Blaok board, PPT, Vi

Activities

on differenttopics by each student.

for presentalion in ihe class.

on differcnt topios during the semester.

ous cuneni sc;entific affai$.Discussionson

{ g.-"-Ic_O' '

*.,ip..;\;r;,; s"

Cond€nsed five and six memberedheterooyoles Synthesis, reactivity:Benzofumn, Benzothioph€ne,Benzooxazoles, Benothiazol€,s,Benzimidazoles, Indole, Isoquinoline and

Quinoline. Synthesis, reactivity, arcmaticcharacter and biolosical impodance offollowing heterocycles:1,2,3-ttiahle, 1,2,4-ttiaznle, 1,2,4-oxadiazole, 1,3,4-oxadiazole,

08

Assignment preparation on different topics by €aoh student.

Prepararion ofPPT for presentation in the class.

Presentation by siudents on different topios during lhe s€mester.

Dhcussions on various curent scientific affairs.

Unit Topic ethod of No.

IV

H€terccyclic Chemistry-IlSix membered heterocycles: Synihesis, reactivity, aromatic charaoter andimporlance of following heterocyclic r;ngs: Pyridine, Pyrimidine, Pyrazine,Diazines. Triazines. Tetrazines and Thiazines.

06

Seven and larye membered het€rocyclesr Synthesis and reactrons of azepanes,oxepines, thi€pines, diazepines, thiazepines, azocines, diazocin€s, dioxocinesand dithiooines..

04

Synthesis of5- and 6- membered Heterocycles coniaining P, As, Sb and Bi.Meso-ionio compounds: ceneral olassification, chemisiry ol sone important

meso-ionic heterocycles oftype-A and type-B and their aDDlications

06

Assignment preparation on different topics by €ach student.

Preparation ofPPT for preseniation in the class.

Presentation by students on diff€rent topics during the semester.

Discussions on various cunent soieniifio affairs. J",ffi

Acdvltles

Course code: CPT-4.2

Coursetitle:

Method oflnstructiona

Optical

Chirality i.

Optical

Chiraliiy of

CIP rules

in th€ absence of chiral

biphenyls, adamentanes, ansa

rotaxanes and helicenes.R, S- configuration to thes€

due to the presence h€tero

ic compounds due !o th€Iicon, ritrcgen, phosphorcus,

atoms. Determination ofof thes€ conpounds using


aalysis of medium rings.r€actions: Hydrclysis of

epoxides and bromination of

DeterDinirconfigu

ChemicalM€thodsChemical

Methods

Use opticalaxial halo'

determinat;substituted

of configumlioniinvol ng the ohiral centre.

involving the chiralical conelarion involving

on compadson of opticalrule, Rule of shift, Rule of

ition, Mill's rul€, Methodrotarion differcnc€. The

disp€rs;on curyes: o-rule and its applications,

lication of these mles in theof absolute configuration of

Method based on anomalous


spproach'Intrcducfion tod synth€tic €quivalents,

approacb. Basic principles andused in disconnection

Actlvlties

on different topics by each stud€nt,

Pr€paration ofPPT fof

on diff€rent topics dur;ng the semester.

Dhcussions on various scientific affairc.

00s

J--r"-",,ry-

,'l.T*,,'''' ''

Activities

. Assignmeni p|€pamtion on different ropics by each studenr.

. Prcparalion ofppT for presentation in the class.

. Presentaiion by stud€nts on differenr topics duflng the sem€s|€r.. Dscussions on various current scientific ai.fai.s.

. Assignment preparation on differcnt topics by each stud€nt.

. Prepamtion ofppT for presenration in the ctass.

Pr€s€ntation by snrdenrs on different topics during the sernester.Discussions on various cun €nt scientific affairs.

Activiti€s

. Assignment prepamrion on differ€nt topics by each stud€nt.. Preparation ofppT for presentaiion in the class.Presentation by studenrs on different topjcs during me sem€s!€r.Discussions on various cunent sci€nlific affairs.

approach. One group c-r, and two group C-

^ oNconnecnons. Chemosetectivity. rev;rsaiof polarity, cyctisatlon reactions

- C-C.one$oup ald C-C h,-;glo,rp dis"on,lcclrons - --""lljli.jll ^"1,"1::l"l:.

c€rbon)r compounds and arkenes. Lse ofiT,y,*: y aripharic niuo ";,p"_;, i; organic synthesk. Diets_Aoer^,reac,ion..i.3_difuncrionathed compoun;s. o. p_ un,arurui€d::T!:""9" ::'f""{r -,n"*d, *";";;;;;"; r.)_di.runcjo%risedconpoJnd". Micheat addirion and Robinro" *nuL,io".

ning Synrtre.si-Sylrtresis or.aru"area trervoovcte+r,-..4-. )- and 6_n embercd r;ngs. Named Reacti;ns in[:l:lo?c.rc. s]n,hesisi c*ii"_si.pr,.", ?-"'"p'r,,d"herne Keaction. pa,erno_Bijchi Reac1,on, Bi;inenireacflon. Han{zsch dihydropyridine syn$esisi vunrec.rman reacrion and Hofmann,L;meFF;elrasreaction.

Black boa.d, ppT,Vjd€o, Discussion

:flg:::',,:, da-o.pG" ;dG,r"" _trff:i5!"" ..approach: Aromadendre,,<,

Juvabione. tredericamlcin_A and Lycorane. ''

Jt, i,_\ I U.(

Collrs(

Cours(

coder SPT-4.3 A

titlsORGANUt Topic Method of hstructlons

I

UV Visibl

T€chnotogy

' spectroscopy: Quanlitativeabsorption Beef's law,associated with absorption

:s. Linit tions ofthe law - real,,trumentrl and personal. Th€ory

absorpiion. Vibradon roiriion, of electronic spect|a, Types of

ds- n to ,r*, r to ft*, n to o*o*, C-T and lisand nlld.enpirical rules for predicting

rth of maximum absorption for

'sated dienes, cyclic tri€nes and

0- unsaturated aldehydes andzene and substiiut€d benzene

Black boar4 PPT, Video,Discussion

06

Applicationlanalysis ofof dissociatideterminatkdeterminatic

kinetic studi

Qualitative and quantitative

'inary mixtures, measur€mentsn constants of acids and bases,

' of molecular w€ieht,r of stoichiometry and stabilityixes. Photometrio titrations and

04

Sampling tfactors affer

of H-bon

Raman. IdIdeniificatioAmin€s, Esl

al Spectroscopychniques, Group fiequeroies,ting group frequ€ncies, Bond-eff€ct, Conjugadon, Induciive,teric €ff€cts. Intra-molecularApplicaiion of IR in the studying, stereo;somedsm andComplimentariry of IR and

ntification of Tautomerism.of the following Amides,

rs, Halides, Niho compounds,r using UV and IR.

Do 06

Activities

. Assignmentpr€paratio

. Preparation ofPPT for

. Presentation by studen

. Disoussions on variou:

on different topics by each sludent.

rresentation in the class.

r on different topics during the semester.

cur1ent scientifi c affairs. ! \,:^,r_,_7_.^ or.r,,', t',t,.,n,r,u

[os '"0 e h.oii;,

' ,'"''tv

{i$iiH'n" 'o'"

Activities

.I

Unit Topic M€thod of Instructions No. classes

need€d

u

Nucletr magnetic

Inlroduction, Magnetic properties of nuclei-Resonance condition. Nucl€ar spin,population of nuclear spin levels and NMRisotopes, Relaxalion methods.Insturmetnation and sample handling, FT-NMR. Chemical shiii. Meohanism ofshielding and deshielding in Alkanes, Alkylhalides, Alkenes, Aromatic compounds,Carbonyl compounds and Annulenes.Pascal's triansle-low and high resolution,spectrum of ethanol. Karplus Curve,

Black board, PPI, Video,Discussion

08

Diamagnetic and paramagnetic €ffects andmagnetic anisotropy. Equival€nce ofprotons"ohenical and magnetic eqrivalence.Spin-sysiens: First order and second orde.coupling ofAB syst€ms, Simplifications ofconplex spectra's. Problems. Spin-spininteractions: AX, AXz, AX3, AMX, ABtypes. Vicinal, geminal and long rangecoupling-Spin decoupling. Chemical shiftreagents and deuterium exchange.Stereochemistry and hinder€drotations.

08

Assignmeni preparation on different topios by €aoh student.

Prepamtion of PPT for presentation in the olass.

Presentaiion by stud€nts on different topics dudng the sem€srer.

Discussiors on vafious curent sci€ntific affairs.

Untt Topic Method of Instructions No. cla$e!

ne€ded

III

Nuclcar magneticsPectroscopy-IlCIDNP, Nuclear Overhauser eilecl (NOE).Factors influencing coupling constants andRelative intensities. Protons attached ioelements other than carbon.

13C NMR Spectroscopy: Range and factorsaffecring chemioal shifts of alkanes, alkylhalides,alkenes, alcohols, €thers, alkynes, ca$onylcompounds and arcmatios.


06

. . lyr.rrir.irr 1sr,

' : i : : :.: ;,' 7, i ij;:;r,;

Multiple

cosY,Explanation

Dynanicnuolei withl9F, 29SiChemicaland 3lP

spechoscopy:to 2D-teohniqu€s: DEPT,

ANd INADEQUATE.the principle, applicaiions io

dation and stereoohemistry of

NMR spectroscopy of oth€rn I = '/,. Introduction to 15N,

3lP NMR spectroscopi€s.ft values fo. l5N, l9F, 29Si

metry snd Composite Problems:eeinstrumentation - ion production, ion analysis,

, instruments, Quadmpole mass spectromet€rs. Time olometers-ion cyclotron resonance spectrom€ters- Massar ion-types of ions in mass specta and effects ofspectra. Methods of ionization, EI, FAB mass and

flight mass

MALD]

Black board,PPT, Vid€o,Discussion

peptides,

Composite

formulae of

of Alkanes, Alkenes, alkyl halides, alcohols, ald€hydes,

esters, eihers, amines, nitro and halo compounds

rule, Faotors aff€ctihg cleavage patlems. Mcl-aff€rty

+l r€aransmenl. Det€rmination of mol€cular formula.

blens. Use of HRMS ao d€termin€ exact mol€cular

pplio3tion of UV, IR, NMR and MS methods

reactions in the struclure elucidation of organic

Activities

Presentalion by

Discussions on

on diff€rent topicsby each stud€nt.

Preparation of PPT presentation in the olass.

on different topics during the s€m€st€..

curfent scientifi o atlairs.

on different topics by eaoh student.

Preparation of PPT presentarion in the class.

Activttt€i

Disoussions on

I on dilrerenr ropics duringthe semesrer. P .C*J-A'"-\ '+cunent scientific affairs.

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.I i'.).- ((

Documents

Transcript of .I i'.).- ((