DISFUNÇÃO HORMONAL

EPIDEMIOLOGIASAÚDE

ACTIVIDADE FÍSICA

André Bento

EVOLUÇÃO DA ESPÉCIE

ANDRÉ BENTO

POPULATION DECLINES IN SERUM T(n1=1374, n2=906, n3=489)

The Journal of Clinical Endocrinology & Metabolism, January 2007, 92(1):196–202

POPULATION DECLINES IN SERUM T(n1=1374, n2=906, n3=489)

The Journal of Clinical Endocrinology & Metabolism, January 2007, 92(1):196–202

• LOW-SERUM T• Abdominal obesity• Diabetes

• Pre-diabetes (insulin resistance, impaired glucose tolerance, metabolicsyndrome)

• Dyslipidemia• Low bone and muscle mass• Impaired sexual function• Depressed mood• Decreased quality of life

“Suppose, for instance, there were an unmeasured but persistent environmental exposure associatedwith decreased T levels, affecting recent generations of men at birth.”

ANTIANDROGENS IN EFFLUENTS FROM WASTEWATER TREATMENT WORKS

Environ Health Perspect 117:797–802 (2009). doi:10.1289/ehp.0800197

MAN WITH BOOBS

• ESTEROIDES-TESTOSTERONA EM EXCESSO CONVERTIDA EM ESTROGÉNIO

• EXCESSO DE PROTEÍNA CONVERTIDA EM GORDURA

• PATOLÓGICA (GINECOMASTIA)

• BEBER ÁGUA?

EFFECTS OF CORTISOL AND GROWTH HORMONE ON LIPOLYSIS

The Journal of Clinical Endocrinology & Metabolism 85: 799–803, 2000

GH

• SLEPP

• ACID LACTIC

• RT, HIT, HIIT, HIRT

CORTISOL

• Insulin

• LPL

• CALÇADÃO

LIP

OLY

SIS

LIPO

LYSIS

“Furthermore, the present results suggest that the lipolytic effect of GH is strengthened in the presence of cortisol.”

A QUEM IMITAMOS??

• Insulina + LPL• IN --> HC

• FFM & FM• Fatty Acids

• Glucagon + HSL• OUT --> FATTY ACIDS

The Journal of Clinical Endocrinology & Metabolism 85: 799–803, 2000

BOTTOM LINE – Não hibernem… INCINEREM!!!

↓TESTOSTERONA

• sarcopénia

• Redução MET

↑ESTROGÉNIO

• Feminização

• Aumento da MG

↑CORTISOL

• Potencia LPL

• Acumulação de gordura abdominal