CURRICULUM VITAE - Johns Hopkins Medicine

Paul A Bottomley, updated 2/26/2020

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CURRICULUM VITAE

Paul Arthur Bottomley

Address: Department of Radiology, Johns Hopkins University, Park Bldg 310. 600 North Wolfe Street, Baltimore, MD 21287, USA.

PH: 410 955 0366 (work) FAX: 410 614 1977 E-mail: [email protected] Born: Australia, 1953 Wikipedia: https://en.wikipedia.org/wiki/Paul_Bottomley_(scientist)

_______________ EDUCATION

1965-1970 Higher School Certificate, Frankston High School, Victoria, Australia. Subjects: Chemistry, English, Applied Mathematics, Pure Mathematics, Physics.

1971-1974 Bachelor of Science with Honors, Monash University, Victoria, Australia. Honors major: Physics. Honors Classification: First Class; top in Experimental Physics, third overall. BSc thesis: “A 12 foot radio-telescope”. Honors thesis: “An NMR study of the clathrate hydrate of Xenon”. BSc subjects: Physics (major), Applied Mathematics, Chemistry (sub-major).

Oct 1975-May 1978 Doctor of Philosophy, University of Nottingham, England. Subject: Physics, NMR imaging.

Awarded Nottingham University Demonstratorship. Thesis: "NMR imaging by the multiple sensitive point technique". Advisor: E Raymond Andrew, FRS.

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INTERESTS The application of nuclear magnetic resonance (NMR) techniques to biophysical, biological, and medical problems. The theoretical, experimental, and technical development of NMR imaging (MRI); the development of methods for performing spatially localized spectroscopy (MRS), measuring relaxation times, metabolite concentrations, kinetic reaction rates, energy supply and work in vivo using NMR. The application of these technologies to the noninvasive study of human disease. Measurements of energy metabolism with phosphorus (31P) and proton (1H) MRS in patients with heart disease. Sodium (23Na) MRI in patients with ischemia and/or cancer. Stress testing for ischemia using 31P MRS. MRI detectors comprised of coils, strips, and arrays. Intravascular and internal MRI coils for imaging vascular disease, and their combination with therapy delivery devices to perform MRI-guided therapy. High-speed cardiovascular MRI. Molecular imaging and new biomedical imaging modalities.

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PROFESSIONAL HISTORY Dec 1971-Feb 1972

Information Scientist, Commonwealth Bureau of Meteorology, Melbourne, Victoria, Australia.

1974 Physics Laboratory Demonstrator, Department of Physics, Monash University, Victoria, Australia (teaching 6 hr/wk).

1975 Demonstrator, Department of Applied Physics, Caulfield Institute of Technology, Victoria, Australia (teaching 13 hr/wk).

Physics Lecturer, Swinburne College of Technology, Victoria Australia (teaching period: 6 hr/wk).

Oct 1975-Aug 1978 Demonstrator in Physics, Department of Physics, University of Nottingham, England.

Oct 1978 Research Scientist, Department of Physiological Chemistry, Johns Hopkins University, Baltimore, MD, USA.

July 1979

https://en.wikipedia.org/wiki/Paul_Bottomley_(scientist


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Research Associate, Division of NMR Imaging, Department of Radiology, Johns Hopkins University, Baltimore, MD, USA.

Aug 1980-May 1994 Physicist, General Electric Company, Corporate Research and Development Centre, Schenectady, NY, USA. Coolidge Fellow: (sabbatical), MRC Magnetic Resonance Unit, John Radcliffe Hospital Headington and the Department of Biochemistry, Oxford University, UK, Sept 1992-June 1993. Adjunct Appointment: Visiting Associate Professor of Medicine at the Johns Hopkins University School of Medicine, Baltimore MD, July 1, 1991-1994.

May 1994-present Russell H Morgan Professor, Department of Radiology, Johns Hopkins University, 600 North Wolfe Street Baltimore, MD 21287-0843, USA. Joint appointments: Professor of Medicine, Professor of Biomedical Engineering, Professor of Electrical and Computer Engineering, Whiting School of Engineering, Johns Hopkins University.

Jan 1997-present Director, Division of MR Research, Department of Radiology, Johns Hopkins University, Jan 1997 Director, MRI Research Service Center (Johns Hopkins University), Jan 1997. Director, NMR Service Center (Johns Hopkins University), Feb 2005

Sept 1998-2014 Member, Board of Directors, Surgi-Vision Inc then MRI Interventions Inc.

May 2002 Interim Vice Chairman for Research, Department of Radiology, Johns Hopkins University

Sept 2018-Mar 2019 Newton Abraham Visiting Professor & Fellow, Lincoln College, University of Oxford, UK.

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TEACHING Courses Taught

1. “Magnetic Resonance in Medicine”. EN.520.473, EN.520.673; EN.580 473, EN.580.673; Departments of Biomedical Engineering (BME) and Electrical and Computer Engineering (ECE). 6 hrs/1994, 1996, 1999-2015. Course organizer, responsible faculty for course content, teaching & grading 33-hrs (teach 50%) 2017-18.

2. “Topics in BME”, BME Dept. May 2000, 2 hrs.

3. “Basic MRI physics”, Residents/Fellows, Department of Radiology, 2hr lectures annually ~2001-5;

4. “Research for Residents” 2002, 2005.

5. “Advanced Topics in MRI.” ECE Dept. 520/580.748 2007, 2008. 2 hrs annually.

6. “Modern Biomedical Imaging-Instrumentation and Techniques”. Spring 2009-2015. ECE Dept 520.434; BME Dept. 580.472. 3 Hrs.

7. “Independent Study”, #EN.520.800. Dept of Whiting School of Engineering., ~6-20 hrs annually. 2010-18 (skipping some years, depending on request).

Teaching Research

Graduate students supervised:

1. Pfeifer LM. GE research & Development Center Summer Student program, 1983 (refs # 38, 47)

2. Allen-Moore G. GE research & Development Center Summer Student program, 1983 (ref # 68

3. Lee YH. “Localized spectroscopy of creatine in human skeletal muscle and heart”, thesis for MSE, Department of Biomedical Engineering, Johns Hopkins University May 1996.


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4. Constantinides CD. “Sodium MRI techniques and applications to acute reperfused myocardial infarction”, thesis for PhD, Department of Biomedical Engineering, Johns Hopkins University, May 2000.

5. Lee RF. “Parallel magnetic resonance imaging: encoding theory and antenna design”, thesis for PhD, Department of Electrical Engineering, Johns Hopkins University, May 2000.

6. Kumar A. PhD. “Performance optimization of local magnetic resonance surface coils and antennas”. Department of Electrical Engineering, Johns Hopkins University, 2002-8.

7. Gabr R, PhD. “Measuring cardiac energetics with magnetic resonance”. Department of Electrical Engineering, Johns Hopkins University, 2004–2009

8. Panda S. MSE. “Efficient method to determine relaxation parameters and proton density”. Department of Biomedical Engineering, and Department of Electrical and Computer Engineering, Johns Hopkins University, 2003 –2006

9. Sathyanarayana, S, PhD. “Dynamic MRI using internal detectors.” Department of Electrical Engineering, Johns Hopkins University, 2005–2009.

10. El Sharkawy, AM, PhD. “Thermometry and magnetic resonance imaging”. Department of Electrical Engineering, Johns Hopkins University, 2005–8

11. Stralka, J, PhD student, Department of Electrical Engineering, Johns Hopkins University, 2006-7.

12. Qian, D, PhD. “Higher field loopless interventional MRI dtectors and their safety”. Department of Electrical Engineering, Johns Hopkins University, 2007-2012.

13. Zhang, Yi, PhD. “Advancing magnetic resonance spectroscopy and endoscopy with prior knowledge”. Department of Electrical Engineering, Johns Hopkins University, 2009-2014.

14. Erturk, Mehmet, PhD. “Enabling interventional MRI using an ultra-high field loopless antenna”. Department of Electrical Engineering, Johns Hopkins University, 2009-2014.

15. Wang, Guan, PhD. “Quantitative Mapping in Magnetic Resonance Imaging”. Department of Electrical Engineering, Johns Hopkins University, 2010-2015.

16. Current (2020): Xiaoyang Liu, Dan Zhu

Thesis committee/thesis examiner for (in addition to the above): All students listed in #3-15 above, plus: Hsu EWX, PhD, 1996; Atalay MK, PhD, 1996; Reeder B,

PhD, 1997: Greenman RL, PhD, 1999. XXX _________________________________

HONORS, AWARDS, etc

1. Awarded Australian Commonwealth University Scholarship 1972-1974.

2. Awarded 1st Class Honors in Physics (BSc), top in experimental physics, 3rd overall in Physics, Monash University 1974.

3. Awarded Nottingham University Demonstratorship, 1975.

4. General Electric managerial awards 9/82, 12/82, 2/84, 1988, 1989, 1991, 1992, 1993.

5. Awarded Dushman Award of the General Electric Research and Development Center for outstanding work resulting in the development of high field nuclear magnetic resonance imaging and spectroscopy, 1983.

6. Appointed to editorial boards: • Magnetic Resonance Imaging (Pergamen Press) 1982-present • Magnetic Resonance in Medicine (Academic Press) 1983-2004. Associate Editor 1991-2004.

Deputy Editor, 2010- present. • Review of Scientific Instruments (AIP) 1986-1988


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• Radiology (RSNA) Associate Editor, 1991-1995 • MR Quarterly (Miller Freeman), Editorial consultant, 1991-1994. • Magnetic Resonance Materials Physics, Biology & Medicine (MAGMA), 2003-present). •Encyclopedia of Magnetic Resonance, International Advisory Board 2006-

7. Publication Awards: General Electric Research and Development Center publication awards: • 25 publication award, March 1984 • 50 publication award, March 1986 • 75 publication award, March 1990.

Johns Hopkins University Dept of Radiology MR Research Division publication awards: • 125 publication award, Oct 2003 • 150 publication award, Oct 2008 • 175 publication award, Oct 2013 • 25 patent award, Oct 2006 • 50 patent award Oct 2019.

8. Leadership Awards: • 2004 Department of Radiology, presented at the 7th Annual Retreat, Oct 7-8 2004; • 2017 "Plaque presented in grateful appreciation of 20 years of Vision and Leadership at the 20th

annual research retreat of the Division of MR research" Division of MR research, Department of Radiology, 20th Annual Retreat Liberty Mt PA, Oct 26 2017.

9. Elected to the Boards of Trustees: • Society for Magnetic Resonance Imaging, 1982-1986. Appointed to Exec. Committee, 1982 • Society of Magnetic Resonance in Medicine, 1986-1989. Appointed to the Membership and Future

Meetings Committees, 1987-1989; the Awards Committee 1990-1994; Chairman, Exhibits Committee, 1987-1989.

• International Society of Magnetic Resonance in Medicine (ISMRM), 2007-10, ISMRM Publications & Communications Committee.

10. Appointed to American College of Radiology Commissions on: • Biological effects of NMR, 1982-1989 • Subcommittee on NMR architectural design, 1983-1985.

11. Awarded General electric (GE) patent medallions: • Bronze medal for 1 patent application, 1981 • Silver medal for 10 patent applications, May 1985 • Gold medal for 20 patent applications, March 1989.

The GE 1.5Tesla whole-body MR imaging system is a direct result of one of these inventions.

12. Honored by New York State Legislature resolution (Assembly No. 1246) for scientific and technical achievements, May 30, 1985.

13. Editors Recognition Awards: • “For special distinction in reviewing articles for "Radiology", 1986; 1988, 1989, 1990 • 2011 Referee’s recognition award for distinguished service to J Magn Reson Imag; • 2010-18 Referee’s recognition award for distinguished service to Magn Reson Med.

14. Awarded 1989 Gold Medal of the Society of Magnetic Resonance in Medicine for "Pioneering scientific contributions to magnetic resonance in medicine" at the Aug. 1989 meeting of the Society in Amsterdam, The Netherlands.

15. Fellow, International Society for Magnetic Resonance in Medicine (ISMRM), 1989 •Member, American Association of Physicists in Medicine •Member, New York Academy of Sciences. •Member American Heart Association.

16. Current Contents Citation Classic. Author of “Citation Classic”, Bottomley PA, Andrew ER. Phys Med Biol 1978; 23: 630-643. In: Andrew ER (Editorial), Current Contents, April 23 1990; 17: 24.


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17. Awarded 1990 Coolidge Fellowship and medal for outstanding and sustained contributions to Science at the GE Research and Development Center, including pioneering contributions to magnetic resonance in medicine.

18. Chosen as one of 12 of "America's Hot Young Scientists" Fortune Magazine, October 1990.

19. Member, Board of Directors, Surgi-Vision Inc, and MRI Interventions Inc, a start-up company formed by JHMI and founding faculty to develop interventional MRI probes and devices, 1998-2014.

20. Medical Physics Top Ten Papers. Author of most-cited (Bottomley PA, et al Med Phys 1984; 11: 425-448) and fourth most-cited (Bottomley PA, et al Med Phys 1987; 14: 1-37) papers published in Medical Physics. In: “Medical Physics top ten”, Patterson MS (Editorial). Med Phys 2004; 31: 682.

21. Presentation Awards: • 2004 AHA Scientific Sessions 2004 Poster finalist, Clinical Science: Najjar et al, ”Exercise-Induced

Ischemia in Patients with Coronary Artery Disease?” (#162), • 2015 ISMRM Magna cum laude: Zhang et al, “Highly-Accelerated Chemical Exchange Saturation

Transfer (CEST) Measurements with Linear Algebraic Modeling (SLAM)” (#779). • 2015 ISMRM Magna cum laude: Ertürk et al “A combined interventional high-resolution targeted

ablation, thermometry and imaging probe” (#1645). • 2018 ISMRM Magna cum laude: Liu et al, “Real-time MRI endoscopy at up to 10 frames/sec”. (#603) • 2018 Best paper, interventional MRI: Liu et al, “Intra-vascular, MRI-Guided, perivascular ultrasound

ablation with thermometric monitoring of therapy delivery.” (#1194)

22. Sir Peter Mansfield Lecturer, “Localiuzed Origins” 20th Annual ISMRM meeting, Melbourne Australia 5-11 May 2012.

23. “Distinguished Investigator”, Academy of Radiology Research, Washington DC USA, Jun 2012.

24. Awarded 2015 Gold Medal of the American Roentgen Ray Society, Toronto, Canada April 19 2015.

25. Elected to the National Academy of Inventors, November 2015.

26. 2018-2019 “Newton Abraham Visiting Professor”, University of Oxford, UK and Fellow, Lincoln College, University of Oxford, UK

XXX GRANTS AWARDED

1. NIH R01 MH48639. “Quantitative metabolic changes in AIDS dementia by NMR”. Cousins JP PI; Bottomley PA co-investigator. 1992-1995.

2. GE gift to support cardiovascular MR Research, Bottomley PA, PI. 1994. Total award amount: $20,000.

3. NIH 1P50 HL52315. “SCOR in ischemic heart disease”, Becker L (PI). Project 6: “Metabolic characterization of reperfused dysfunctional myocardium by NMR”, Weiss RG, PI; Bottomley PA, co-investigator, 4/1/95-00.

4. NIH, 1R01 RR11454. “Research scanner for high-speed combined MRI/MRS”, van Zijl P PI; Bottomley PA co-investigator. NIH shared instrumentation grant. June 1997-May 31 1998.

5. NIH, 1RO1HL56882. “Proton magnetic resonance studies of myocardial creatine”, Bottomley PA, PI; 1997-2009. Total award: $859,110. AIMS: To develop and validate quantitative measurements of the regional distribution of total creatine in the human heart in vivo by non-invasive spatially localized proton MRS. To test whether spatially localized proton MRS can differentiate normal from infarcted myocardium. To test whether creatine and phospate metabolite levels are reduced in surviving myocardium in the failing human heart in proportion to the severity of heart failure, using combined phosphorus and proton MRS.

6. GE grant to support research student fellowships, Bottomley PA PI. 1997. Total award amount: $20,000.

7. Whitaker Foundation. “High Resolution Imaging and Spectroscopy of Atherosclerotic Plaques using Intravascular MR”. Atalar EA, PI; Bottomley PA, co-investigator; 4/01/95 - 03/31/98.


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8. NIH, R21 HL62332. “Noninvasive high-energy phosphate imaging”, Bottomley PA, PI; 9/21/98-9/20/01. Total award: $242,284. This grant combines for the first time, the sensitivity advantages provided by the physics technique of nOe with the Electrical Engineering technique of phased array detection, and the chemical-selective MRI of Medical Imaging and Computer Science to create sensitivity-enhanced HEP imaging, and to apply it to the human heart.

9. NIH, K01 HL03837-01. “MRI of Vascular Function in the Hypertensive Heart”. G Beache PI; Bottomley PA, Co-PI and mentor 07/01/98-06/30/00(3). $101,831 DC/yr. The major goal of this project is to study concept and methods relevant to the non-invasive imaging of vascular function of heart disease using MRI to refine and implement a new MRI method to detect and quantify vascular dysfunction in the human hypertensive heart.

10.NIH R01HL61672. “Intravascular Magnetic Resonance: Towards Clinical Interventions.” Atalar EA, PI; Bottomley PA, co-investigator, and Interim PI, 2003. 12/1/98-11/30/04.

11. NIH, 1R01-HL61695. “Sodium Imaging in Ischemic Heart Disease”. Bottomley PA, PI; 7/01/99- 6/30/04. Total award amount: $1,273,178. AIM: To develop and optimize sodium (23Na) MRI for the normal human heart and to use it to assess myocardial viability in patients with myocardial infarction and with ischemic heart disease.

12. NIH, 1R01 HL61912. “Contribution of energy depletion to human heart failure” RG Weiss, PI, Bottomley PA, Co-PI (20%) 7/01/99 - 6/30/04. Total award amount: $1,622,758. AIMS: To test the hypotheses that myocardial creatine kinase metabolite concentrations are reduced in proportion to severity in heart failure and predicts progression, that CK energy reserve in the failing heart differs in response to energy demand, and that creatine supplementation may improve myocardial energetics in the failing heart.

13. NIH, R01 HL64795. “Magnetic resonance guided electrophysiology intervention”, H. R. Halperin, PI; Bottomley PA, coinvestigator (5%). 1/1/00-12/31/07. Total award amount: $2,439,780. AIMS: MRI is used with trans-esophageal, intracardiac receivers MRI compatible electrode catheters for navigation of catheters, visualization of ablated lesions, and for the production of more accurate electrical maps for the treatment and monitoring of atrial fibrillation. This is a joint partnership between Johns Hopkins Medical Institute, Johns Hopkins Applied Physics Laboratory, SurgiVision Inc., Robin Medical Inc, and Bard Electrophysiology Inc.

14. NIH, P20 CA86346 ”Multidisciplinary functional imaging of cancer” . Bhujwalla Z, PI; Bottomley PA, lead investigator (3%). 3/1/00-2/28/03. Total award amount: $1,200,000.

15. NASA, National Space biomedical Research Institute (NSBRI). “Development of a space qualifiable MRI system”. Bottomley PA, PI. 2/01-2/02. Total award amount: $1,200,000/3 yrs.

16. NIH, 1R01 RR15396. “Innovative MRI research technology”, Bottomley PA, PI, 9/01-9/08 Total award: $4,366,003. AIMS: In this grant, responsive to PAR 99-009, new insertable flat MRI gradient coils are developed for a whole body MRI system to greatly increase MRI gradients speed and strength, and evaluate it for safety and in patient diffusion studies of stroke. A high-speed 8-channel phased array system employing sensitivity encoding to push MRI speeds to 40 frames/s is developed, and used to detect wall motion abnormalities during stress in patients with heart disease. High speed T1 imaging is developed and used for T1 MRI in human subjects and for monitoring temperature changes during RF ablation therapy. Finally, tools and MRI detector coils are developed that provide performance approaching the optimum intrinsic signal-to-noise ratio, and demonstrated them in human studies.

17. NIH, 5T32 HL07712-10. “Research Training in Interventional Radiology” (Training grant), Bottomley PA, PI. July 1, 2000-June 30, 2005. Total award amount: $500,415. A multi-disciplinary faculty is assembled and diverse training and research environments provided for training of post-doctoral trainees in Interventional Radiology supported by this grant.

18. NIH, 2R01 HL56882. “MR Studies of Myocardial Creatine Metabolism”, Bottomley PA, PI; 4/2003-2010. Total award: $2,025,018. AIMS: Quantitative 1H MRS creatine imaging techniques are developed and applied to image metabolic defects and assess metabolic viability in patients with myocardial infarction (MI) and MRI lesions at acute and chronic follow up. The creatine kinase flux is measured in


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the normal resting and stressed human heart, and in MI patients with dysfunction using newly developed FAST 31P MRS techniques. 19. DW Reynolds Foundation, 217280. Cardiovascular Clinical Research Center on Sudden Cardiac Death. Weiss, RG, PI, Bottomley PA, Co-investigator. 07/01/03 – 06/30/10. AIM: The major goal is to find an indicator in cardiac energetics or phenotype to predict risks of sudden cardiac death. 20. NIH 1R01 HL090728 “Advanced Intravascular MRI for Assessing Atherosclerosis.” Bottomley PA, PI; 8/1/08- 5/31/12. Total award amount: $1,632,013. AIMS: This grant provides novel approaches to intravascular MRI for assessing atherosclerosis, promising new, safe, biocompatible MRI probes with major performance gains, and high-speed endoscopic-style MRI methods, with validation in an in vivo animal model. 21. NIH 2R01EB007829 “Advanced MRI Technology in Safety & Intervention”. Bottomley PA, PI; 09/30/2008 – 06/30/2012. Total award amount: $2,157,031. Competitive renewal of 1R01 RR15396 with 4 aims focusing on MRI specific absorption rate (SAR) dosimetry, the development of new high signal-to noise ratio MRI probes and methods for high-resolution MRI, and measuring local heating using MR radiometry. 22. American Heart Association Grant in Aid 13GRNT17050100, “Creatine kinase energy supply in healthy and failing human heart.” Bottomley PA, PI, 7/1/13-6/30/15. Total award amount: $154,000. Develops and validates novel cine MRI methods to noninvasively measure temporal cardiac work and match it with the creatine kinase energy supply measured by 31P MRS. 23. NIH R01 EB007829 “Advanced MRI Technology in Safety & Intervention”. Bottomley PA, PI, 7/11/14 – 6/30/18. Total award amount: $2,206,284. Competitive renewal of grant #21 with 4 aims to develop high speed MRI endoscopy for characterizing atherosclerotic plaques, comparing performance relative to existing intra-vascular modalities, and providing an endoscopic interventional capability. 24. NIH NEI, R21 EY028353 “Direct MEG/EEG detection using a novel MRI approach”. Bottomley PA, PI, 7/1/17-6/30/19. Total award amount $490,625. Pursuant to the Brain Initiative RFA-EY-17-001, this grant aims at developing and testing a new MRI method that provides exceptionally high intrinsic signal-to-noise ratios and speed for directly testing low frequency MEG/EEG signals in the brain.

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PATENTS (Only US patents listed: European and Japanese applications were made for most US patents) 1. Edelstein WA, Bottomley PA. "Method of three-dimensional NMR imaging using selective excitation. US Patent 4,431,968; Feb. 14, 1984. (Filed Apr 5, 1982; RD-13523). 2. Edelstein WA, Bottomley PA. "Use of phase alternated RF pulses to eliminate effects of spurious free

induction decay caused by imperfect 180o RF pulses in NMR imaging." US Patent 4,443,760; April 17, 1984. (Filed Jul 1, 1982; RD-14401).

3. Edelstein WA, Bottomley PA. "Method of NMR imaging which overcomes T2* effects in an

inhomogeneous static magnetic field" US Patent 4,471,306; Sept. 11, 1984. (Filed Feb 3, 1982; RD 13905). 4. Bottomley PA. "Selective volume method for performing localized NMR spectroscopy and NMR chemical shift imaging". US Patent 4,480,228; Oct. 30, 1984. (Filed Oct 15 1982; RD-13822).


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5. Bottomley PA, Edelstein WA (1982) "Method of eliminating spurious FID due to imperfect 180o pulses in NMR imaging: the primer/crusher sequence". US Patent 4,484,138; Nov. 20, 1984. (Filed Jul 1, 1982; RD-14251) 6. Bottomley PA, Edelstein WA, (1982) "Methods for performing two and three dimensional chemical shift imaging." US Patent 4,506,223; Mar. 19, 1985. (Filed Nov 22, 1982; RD 14589). 7. Bottomley PA, Edelstein WA. "NMR imaging of the transverse relaxation time using multiple spin echo sequences." US Patent 4,521,733; June 4, 1985. (Filed May 23, 1983; RD-14589). 8. Bottomley PA. "Methods for selective NMR imaging of chemically-shifted nuclei". US Patent 4,585,993; April 29, 1986. (Filed Dec 14,1983; RD-15054). 9. Bottomley PA, Glover GH. "Method for reduction of motion artifacts in Fourier transform NMR imaging techniques". US Patent 4,614,195; Sept. 30, 1986. (Filed Dec 18, 1984). 10. Bottomley PA. "Method of imaging by depth resolved surface coil spectroscopy." US Patent 4,629,988; Dec. 16, 1986. (Filed Jul 2, 1984; RD-15,472) 11. Bottomley PA (1984) "NMR spectroscopy body probes with at least one surface coil". US Patent 4,636,730; Jan. 13, 1987. (Filed Aug 16, 1984; RD-14,829). 12. Bottomley PA, Schenck JF. "An elliptical slotted tube resonator for NMR imaging". US Patent 4,641,097; Feb. 3, 1987. (Filed May 10, 1984; RD-15,130). 13. Bottomley PA. "Methods of overcoming transient magnetic field inhomogeneity in NMR chemical shift spectroscopic imaging and NMR imaging". US Patent 4,647,858; Mar. 3, 1987. (Filed Jul 29, 1985; RD 15903).

14. Hodsoll RJ, Karr SG, Leue WM, Smith LS, Redington RW, Bottomley PA, Edelstein WA. "Method of, and apparatus for, minimizing magnetic resonance imaging artifacts due to power line interference. US Patent 4,667,159; May 19, 1987. (Filed Jun 10, 1985; RD-15,445). 15. Vatis D, Foster TH, Bottomley PA. "Methods of, and apparatus for, proton decoupling in magnetic resonance spectroscopy". US Patent 4,682,106; July 21, 1987. (Filed Mar 21, 1985; RD 15,858). 16. Bottomley PA, Edelstein WA, Hart HR, Schenck JF, Redington RW, Leue WM. "High-field nuclear magnetic resonance imaging/spectroscopy system" US Patent 4,689,563; Aug. 25, 1987. (Filed Jun 10, 1985; RD 15,197). 17. Bottomley PA. "Methods for localization in NMR spectroscopy." US Patent 4,733,185; Mar. 22, 1988. (Filed Jun 1,1987; RD 18,032). 18. Hayes CE, Foo TK, Perman WH, Moran PR, Bottomley PA. "NMR radio frequency field coil with distributed current". US Patent 4,783,641; Nov. 8, 1988. (Filed Aug 13,1987; MSG 15-NM-2644). 19. Bottomley PA, Hardy CJ, O'Donnell M, Roemer PB. "Multi-dimensional selective NMR excitation with a single RF pulse". US Patent 4,812,760; Mar. 14, 1989. (Filed Jul 27, 1987; RD 17,692). 20. Bottomley PA, Roemer PB, Mueller OM, Edelstein WA. "Method of and apparatus for NMR spectroscopic metabolite imaging and quantification". US Patent 4,881,032; Nov. 14, 1989. (Filed Oct 21, 1988; RD 18,103). 21. Roemer PB, Bottomley PA, Edelstein WA. "Volume NMR coil for optimum signal-to-noise ratio". US Patent 4,885,539; Dec. 5, 1989. (Filed Jun 6, 1988; RD 18,727).


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22. Bottomley PA, Hardy CJ. "NMR probe with multiple isolated coplanar surface coils". US Patent 4,973,908; Nov. 27, 1990. (Filed Jun 23, 1989; RD 19,348). 23. Hardy CJ, Bottomley PA, Cline HE. "Spectroscopic localization using pinwheel NMR excitation pulses." US Patent 5,192,909; Mar. 9, 1993. (Filed Jan 7, 1991; RD 20,047). 24. Bottomley PA, Hardy CJ. "Spatially-localized chemical reaction-rate NMR spectroscopic imaging". US Patent 5,201,311; April 13, 1993. (Filed Aug 11, 1989; RD 19,390). 25. Dumoulin CL, Bottomley PA, Souza SP. “Magnetic resonance active invasive devices for the generation of selective MR angiograms”. US Patent 5,447,156; Sept. 5, 1995. (Filed Apr 4, 1994; RD 21,822). 26. Bottomley PA. “Absolute metabolite concentrations from poorly spatially-resolved MR response signals”. US Patent 5,500,592; Mar 19,1996. (Filed Oct 31, 1994; RD 23,538). 27. Atalar E, Bottomley PA, Zerhouni E. “Method of internal magnetic resonance imaging and spectroscopic analysis and associated apparatus”. US Patent 5,699,801; Dec 23, 1997. (Filed Jun 1, 1995; DM-9911). 28. Bottomley PA. “Method and apparatus for determining or imaging longitudinal spin lattice relaxation time or producing images which substantially reflect longitudinal spin lattice time contrast”. US Patent 6,064,203; May 16, 2000. (Filed May 20, 1997; DM-9885 ). 29. Atalar E, Lesho JC, Charles HK, Carkhuff BG, Bottomley PA. “Miniature magnetic resonance catheter coils and related methods.” US Patent 6,263,229 B1; July 17, 2001. (Filed Nov 13, 1998; DM-5145). 30. Lardo, AC, Yang X, Atalar EA, Karmarker P, McVeigh ER, Halperin HR, McNamara CE, Bottomley PA. “Magnetic Resonance Imaging guidewire probe”. US Patent 6,675,033; Jan 6 2004. (Filed Mar 24, 2000). 31. Atalar E, Bottomley PA, Zerhouni EA, Halperin H, McVeigh E, Lardo AC. Methods for in vivo magnetic resonance imaging. US patent 6,549,800 B1; April 15, 2003. (Filed Apr 14 2000). 32. Atalar E, Bottomley PA, Karmarkar P, Lardo AC, Zerhouni E. Apparatus, systems and methods for in vivo magnetic resonance imaging. US Patent 6,628,980 B2; Sept 30 2003. (Filed Mar 26, 2001; SUW-014.01).

33. Bottomley PA. MRI tunable antenna and system. (Filed Dec 31, 2002; US. Pat Appl. 20050062472 Mar 24 2005; DM-3771). US Patent 7,088,104; Aug 8 2006.

34. Giaquinto RO, Cline HE, Hardy CJ, Dumoulin CL, Bottomley PA. Multi-turn element RF coil array for multiple channel MRI. (DM-4541, filed Oct 7 2004; application #20050253582, Nov 17, 2005). US patent 7,282,915 B2; Oct 16 2007.

35. Bottomley PA, Kumar A. Optimized MRI strip array detectors and apparatus, systems and methods related thereto. (JHU D04956; Docket #68,363; filed 5/24/07; 2009/0015256). US Patent 7,816,918 B2; Oct 19 2010. 36. Susil RC, Yeung CJ, Atalar E, Lardo AC, Halperin HR, Berger RD, Caulkins H, Atalar E, Bottomley PA. Systems and methods for magnetic-resonance-guided interventional procedures. (SUW-007.02, filed April 15 2002). US Patent 7,844,319 B2; Nov 30 2010.


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37. Tulley S, Lardo AC, Karmarker P, McVeigh E, Halperin HR, McNamara CE, Bottomley PA, Atalar E, Yang X. Magnetic Resonance imaging probe. (SUW-001.03; 10/123,065 filed April 11, 2002). US patent 7,848,788; Dec 7 2010. 38. Bottomley PA, Kumar A. Optimized MRI strip array detectors and apparatus, systems and methods related thereto. (JHU C04956; PCT 20110037468A1 2/17/11). US Patent 8,004,281 B2; Aug 23, 2011. Bottomley PA, Gabr RE. A method for spectral analysis in magnetic resonance spectroscopy data using active circle models. (DM-5067; provisional filed Sept ’06). Abandoned. 39. Atalar E, Allen J, Bottomley PA, Edelstein WA, Karmarkar P. MRI-safe high impedance lead systems. (docket # 9450-7WO; PCT/US2006041109 filed 10/20/06). US Patent 8,055,351 B2. Nov 8 2011. 40. Atalar E, Allen J, Bottomley PA, Edelstein WA, Karmarkar P. MRI-safe high impedance lead systems. (PCT/US2006041109 filed 10/20/06). US Patent 8,433,421 B2. April 30 2013. 41. Atalar E, Allen J, Bottomley PA, Edelstein WA, Karmarkar P. MRI-safe high impedance lead systems. (PCT/US2006041109 filed 10/20/06). US Patent 8,688,226 B2. April 1 2014. 42. Bottomley PA, Stralka JP. A Specific Absorption Rate (SAR) dosimeter for RF power deposition in MRI. (DM5181; PCT/2008/010536 filed Sept 8 ’08). US patent 8,717,021 B2, May 6 2014. 43. Karmarkar PV, Bottomley PA, Allen JM, Edelstein WA, Piferi P, Gore B. Methods and apparatus for fabricating leads with conductors and related flexible lead configurations. (Docket #9450-16PR4; provisional filed 3/13/08). US PCT 20080262584, Oct 23 2008. US patent 9,248,270 B2, Feb 2 2016. 44. Bottomley PA, Sathyanarayana S. Methods, systems and devices for local magnetic resonance imaging. (DM-4893; provisional filed Dec 29, 2006). US PCT 2007026499. US patent 9,482,728 B2, Nov 1 2016. Bottomley PA, Wang G, Schar M, El-Sharkawy AM. Nuclear magnetic resonance methods of measuring transverse relaxation time (T2), T2 imaging, and enhancing T2 contrast in MRI. (JHU Reference C11466, Mar 18 2011; Provisional filed Mar’11). Abandoned. 45. Bottomley PA, Wang G, El-Sharkawy AM. Systems and methods for measuring nuclear magnetic resonance spin-lattice relaxation time T1 and spin-spin relaxation time T2. (C11466/P11466-03; Venable Ref. No.: 2240-340862). Provisional US PCT US20130141096. U.S. Patent (filed Dec 3 2012): 9,494,668 B2, Nov 15, 2016. 46. Bottomley PA, Karmarkar PV, Allen JM, Edelstein EA. MRI and RF Compatible implantable leads and related methods of operating and fabricating leads. (Docket #9450-16PR3; provisional filed 8/14/07). US patent (filed 3/13/2008; pending). US PCT 20080243218, Oct 2 2008. U.S. Patent 9,492,651 B2, Nov 15, 2016. 47. Bottomley PA, Karmarkar PV, Allen JM, Edelstein WA, Piferi P, Gore B. Methods and apparatus for fabricating leads with conductors and related flexible lead configurations. US PCT US 20160220812 Aug 4 2016 continuation of 9,248,270. US Patent 9,630,000 B2, Apr 25 2017. 48. Bottomley PA, Edelstein WA, El-Sharkawy A-M M, Qian D. High-dynamic range RF Power Monitor for MRI/MRS. (JHU Reference C11463, provisional filed Mar 22 2011). US PCT 20140015547 Jan 16 2014. US Patent 9,791,489 B2, Oct 17,2017. 49. Zhang Y, Zhou J, Bottomley PA. System and method of obtaining spatially-encoded NMR parameters from arbitrarily-shaped compartments and linear algebraic modeling. (JHU #C13579 filed May 2015). PCT 20160341808 Nov 24 2016). US patent 10,120,049 B2, Nov 6 2018.


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50. Hengerer A, Rothgang E, Lauer L, Lewin J, Gilson W, Fritz J, Weiss C, Macura K, Bottomley P. Gesture-controlled MR imaging system and method. (JHU C13290, Docket No. 2014P25548US. SMNS-342). PCT 20170123030, May 4 2017. US patent 10,180,469 B2, Jan 15 2019. 51. Bottomley PA, Gabr R, Zhang Y, Weiss RG. System and method of performing magnetic resonance spectroscopic imaging. (JHU Reference C11462, filed Mar 22, 2011). US patent (PCT/US12/30176 filed Mar 22 2012; pending). US 20140015529 A1, Jan 16, 2014. US patent 10,209,330 B2, Feb 19 2019. 52. Rothgang E, Matschl V, Hengerer A, Lauer L, Gilson W, Lewin J, Fritz J, Weiss C, Macura K, Bottomley P. Magnetic resonance imaging coil with adjustable opening. (Docket No. 2014P25546US. SMNS-340). PCT 20170248666, Aug 31 2017. US patent 10,209,325 B2 Feb 19, 2019. 53. Bottomley PA, Zhang Y, Hegde S. Methods and Apparatus for Accelerated, Motion-corrected High-resolution MRI Employing Internal Detectors or MRI Endoscopy. (JHU C12361 filed Apr 4 2013; and Bottomley PA, Hegde S, C12175_P12175-01). PCT 20150257675 A1, Sept 17 2015. US patent 10,292,615 May 21, 2019. 54. Bottomley PA, Karmarkar PV, Allen JM, Edelstein EA. MRI and RF Compatible implantable leads and related methods of operating and fabricating leads. (Docket #9450-16PR2; provisional filed 4/19/07). US PCT 20170113036 Apr 27 2017, continuation of 9,492,651. US Patent 10,391,307. Aug 27 2019. 55. Rothgang E, Hengerer A, Lauer L, Grimm R, Gilson W, Bottomley P, Fritz J. System and method for real-time MRI-guided object navigation. (JHU C13288; Docket No. 2014P25547US. SMNS-341; 10/7/2014). PCT 20170269174, Sept 21 2017. US Patent 10,548,505 Feb 4 2020. 56. Hengerer A, Rothgang E, Lauer L, Lewin J, Fritz J, Weiss C, K. Macura, Bottomley P, Gilson WD. Sterile RF coils for MR imaging systems (Docket No. 2014P25545US. SMNS-339). PCT 20170276742 Sept 28 2017. US Patent 10,459,045 Oct 29 2019. 57. Karmarkar PV, Allen JM, Bottomley PA. RF Compatible implantable leads. (docket #9450-16PR; provisional filed 3/19/07). 58. Zhang Y, Zhou J, Bottomley PA. Method of fast imaging of NMR parameters with variably-accelerated sensitivity encoding. U.S. C14010. US Provisional App. 62/320,197 filed April 10 2017, pending. XXX ___________________________ BOOK Bottomley PA, Griffiths JR. “HANDBOOK OF MAGNETIC RESONANCE SPECTROSCOPY IN VIVO. MRS Theory, Practice and Applications”. John Wiley & Sons Chichester, UK. 2016; ISBN: 978-1-118-99766-6; 1193 pages. PUBLICATIONS 1. Bottomley PA, Pope JM, Cornell BA. A proton magnetic resonance study of the motion of cage water molecules in the clathrate hydrate of Xenon. Mol Phys 1976; 31: 1277-1281. 2. Holland GN, Bottomley PA. A colour display technique for NMR imaging. J Phys. E: Sci. Instrum. 1977; 10: 714-716. 3. Andrew ER, Bottomley PA, Hinshaw WS, Holland GN, Moore WS, Simaroj C. NMR images by the multiple sensitive point method: Application to larger biological systems. Phys Med Biol 1977; 22: 971-974. 4. Holland GN, Bottomley PA, Hinshaw WS. 19F magnetic resonance imaging. J Magn Reson 1977; 28: 133-136.


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5. Hinshaw WS, Bottomley PA, Holland GN. Radiographic thin section image of the human wrist by nuclear magnetic resonance. Nature 1977; 270: 722-723. 6. Bottomley PA, Hinshaw WS, Holland GN. A computer driven photoscanner for medical imaging. Phys. Med. Biol. 1978; 23: 309-317. 7. Hinshaw WS, Andrew ER, Bottomley PA, Holland GN, Moore WS, Worthington BS. Display of cross-sectional anatomy by nuclear magnetic resonance imaging. Brit J Radiol 1978; 51: 273-280. 8. Bottomley PA. A technique for the measurement of tissue impedance from 1 to 100 MHz using a vector impedance meter. J Phys E: Sci Instrum 1978; 11: 413-414. 9. Bottomley PA, Andrew ER. "RF magnetic field penetration, phase-shift and power dissipation in biological tissue: Implications for NMR imaging". Phys Med Biol 1978; 23: 630-643. 10. Hinshaw WS, Andrew ER, Bottomley PA, Holland GN, Moore WS, Worthington BS. Internal structural mapping by NMR Imaging. Neuroradiol 1978; 16: 607-609. 11. Andrew ER, Bottomley PA, Hinshaw WS, Holland GN, Moore WS, Simaroj C, Worthington BS. "NMR imaging in medicine and biology". Proc XXth Congress Ampere (Tallinn, USSR), 1978; 53-56. 12. Bottomley PA. Nuclear magnetic resonance techniques in medicine. Cancer Topics 1978; 2 (2): 4-5. 13. Hinshaw WS, Andrew ER, Bottomley PA, Holland GN, Moore WS, Worthington BS. "An in-vivo study of the fore-arm and hand by thin section NMR imaging". Brit J Radiol 1979; 52: 36-43. 14. Bottomley PA. In-vivo tumour discrimination in a rat by proton NMR imaging. Cancer Research 1979; 39: 468-470. 15. Hinshaw WS, Bottomley PA, Holland GN. "A demonstration of the resolution of NMR imaging in biological systems". Experientia 1979; 35: 1268-1269. 16. Bottomley PA. "A comparative evaluation of proton NMR imaging results". J. Magn. Reson. 1979; 36: 121-127. 17. Bottomley PA. "A versatile magnetic field gradient control system for NMR imaging". J Phys E: Sci Instrum 1981; 14: 1081-1087. 18. Bottomley PA. "In-vivo soft tissue NMR imaging of the rat thorax and abdomen". Experientia 1981; 37: 768-770. 19. Nunnally RL, Bottomley PA. Assessment of pharmacological treatment of myocardial infarction by phosphorous-31 NMR with surface coils. Science 1981; 211: 177-180. 20. Bottomley PA. Digital gradient magnetic field reorientation in three-dimensional NMR zeugmatography. J Phys E: Sci Instrum 1981; 14: 1052-1053. 21. Bottomley PA. Localized NMR spectroscopy by the sensitive point method. J Magn Reson 1982; 50: 335-338. 22. Bottomley PA, Kogure K, Namon R, Alfonso OF. A in-vivo study of cerebral energy metabolism in rats by phosphorous nuclear magnetic resonance using surface coils. Magn Reson Imag 1982; 1: 81-85. 23. Bottomley PA, Edelstein WA. Power deposition in whole body NMR imaging. Med. Phys 1981; 8: 510-512.


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24. Bottomley PA. NMR imaging techniques and applications: A review. Rev Sci Instrum 1982; 53: 1319-1337. Duplicate publication: General Electric Company Technical Information Series, Report No.81CRD195 (General Electric Corporate Research and Development, Schenectady NY)1981, p. 1-23. 25. Bottomley PA. Instrumentation for whole body NMR imaging. In: Witcofski, RL, Karstaedt N, Partain CL, eds. NMR Imaging: Proceedings of an International Symposium on NMR Imaging. Winston-Salem NC: Bowman Gray School of Medicine, Wake Forest University 1982, pp 25-31. Duplicate publication: General Electric Company Technical Information Series, Report No.82CRD203 (General Electric Corporate Research and Development, Schenectady NY) 1982, p. 1-6. 26. Edelstein WA, Bottomley PA, Hart HR, Leue WM, Schenck JF, Redington RW. NMR imaging at 5.1 MHz: work in progress. In: Witcofski, RL, Karstaedt N, Partain CL, eds. NMR Imaging: Procedings of an International Symposium on NMR Imaging. Winston-Salem NC: Bowman Gray School of Medicine, Wake Forest University 1982, pp 139-145. Duplicate publication: General Electric Company Technical Information Series, Report No.82CRD204 (General Electric Corporate Research and Development, Schenectady NY) 1982, p. 1-7. 27. Bottomley PA, Edelstein WA. NMR imaging applications in medicine and biology. Current Problems in Cancer 1982; 1: 20-31. 28. Hart HR, Bottomley PA, Edelstein WA, Leue WM, Schenck JF, Redington RW. “Imaging with nuclear magnetic resonance in a 0.12 T resistive magnet". Proc SPIE 1982; 347: 365-371. 29. Axel L, Herman GT, UDupa JK, Bottomley PA, Edelstein WA. Three dimensional displays of nuclear magnetic resonance (NMR) cardiovascular images. J Comp Assist Tomogr 1983; 7: 172-174. 30. Bottomley PA, Edelstein WA, Leue WM, Hart HR, Schenck JF, Redington RW. Head and body imaging by hydrogen nuclear magnetic resonance. Magn Reson Imag 1982; 1: 69-74. 31. Edelstein WA, Bottomley PA, Hart HR, Smith LS. "Signal, noise and contrast in NMR imaging". J Comp Assist Tomogr 1983; 7: 391-401. 32. Bottomley PA. Nuclear magnetic resonance: beyond physical imaging. IEEE Spectrum 1983; 20: 32-38. Duplicate publication (in Italian): "La risonanza magnetica nucleare: al di la dell' immagine fisica" Electrotechnica 1984; 70(11): 1013-20 (1984). 33. Hart HR, Bottomley PA, Edelstein WA, Karr SG, Leue WM, Mueller O, Redington RW, Schenck JF, Smith LS, Vatis D. Technical alternatives in nuclear magnetic resonance (NMR) imaging. Proc. SPIE 1983; 419: 228-234. 34. Bottomley PA, Hart HR, Edelstein, Schenck JF, Smith LS, Leue WM, Mueller OM, Redington RW. NMR imaging/spectroscopy system to study both anatomy and metobolism. The Lancet 1983; ii (322), 273-274. 35. Kressel HY, Axel L, Thickman D, Alavi A, Pollack H, Arger P. Edelstein WA, Bottomley PA, Redington RW, Baum S. NMR imaging of the chest at .12 T: initial clinical experience with a resistive magnet. Am J Roentgen 1983;141: 1157-1162. 36. Kressel HY, Axel L, Thickman D., Alavi A, Pollack H, Arger P, Edelstein WA, Bottomley PA, Redington RW, Baum S. NMR imaging of the abdomen at 0.12 T: early clinical experience. Am J Roentgen 1983; 141: 1179-1186. 37. Bottomley PA. NMR in medicine. Comput. Radiol 1984; 8: 57-77.


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38. Edelstein WA, Bottomley PA, Pfeifer PM. A signal-to-noise calibration procedure for NMR imaging systems. Med Phys 1983; 11: 180-185. 39. Bottomley PA, Hart HR, Edelstein WA, Schenck JF, Smith LS, Leue WM, Mueller OM, Redington RW. Anatomy and metabolism of the normal human brain studied by magnetic resonance at 1.5 Tesla. Radiol 1984; 150, 441-446. 40. Bottomley PA. The basis of imaging and chemical analysis by NMR. In: Nuclear magnetic resonance and correlative imaging modalities. New York: Soc Nucl Med 1984, pp 37-42. 41. Zimmerman RA, Bilaniuk LT, Goldberg HI, Grossman RI, Levine RS, Lynch R, Edelstein WA, Bottomley PA, Redington RW. Cerebral NMR imaging: early results with 0.12 T resistive systems. Am J Roentgen 1983; 141: 1187-1193. 42. Hart HR, Bottomley PA, Edelstein WA, Karr SG, Leue WM, Mueller O, Redington RW, Schenck JF, Smith LS, Vatis D. Nuclear magnetic resonance imaging: contrast-to-noise ratio as a function of strength of magnetic field. Am J Roentgen 1983; 141: 1195-1201. 43. Bottomley PA. Future advances in NMR imaging/spectroscopy techniques. In: National Conference on Biological. Imaging II. Clinical Aspect. Washington DC: National Academy Press 1984, pp 77-83.

44. Bottomley PA, Edelstein WA, Hart HR, Schenck JF, Smith LS. Spatial localization in 31P and 13C NMR spectroscopy using surface coils. Magn Reson Med 1984; 1: 410-413. 45. Zimmerman PA, Bottomley PA, Edelstein WA, Hart HR, Redington RW, Bilaniuk LT, Grossman RI, Goldberg HI, Bruno L, Kressel H. Proton imaging and phosphorus spectroscopy in a malignant glioma. Am J Neuroradiol 1985; 6: 109-110. 46. Schenck JF, Bottomley PA. Eddy currents in human tissues and whole body nuclear magnetic resonance imaging. In: 1983 Annual Report Conference on Electrical Insulation and Dielectric Phenomena. Piscatway, NJ: IEEE 1983, pp 366-377. 47. Bottomley PA, Foster TH, Argersinger RE, Pfeifer LM. A review of normal tissue hydrogen NMR relaxation times and relaxation mechanisms: dependence on tissue type, NMR frequency, temperature, species, excision, and age. Med Phys 1984; 11: 425-448. (See also front cover). Duplicate publication: General Electric Company Technical Information Series, Report No.84CRD072 (General Electric Corporate Research and Development, Schenectady NY) 1984, p. 1-34. 48. Bottomley PA, Foster TH, Darrow RD. Depth resolved surface coil spectroscopy (DRESS) for in vivo 1H, 31P, and 13C, NMR. J Magn Reson 1984; 59: 338-342. 49. Bottomley PA, TH Foster, WM Leue. Chemical imaging of the brain by NMR. Lancet 1984; I (323): 1120. 50. Bottomley PA, Foster TH, Leue WM. In vivo nuclear magnetic resonance (NMR) chemical shift imaging by selective irradiation. Proc Natl Acad Sci 1984: 81: 6856-6860. 51. Edelstein WA, Schenck JF, Hart HR, Hardy CJ, Foster TH, Bottomley PA. Surface coil magnetic resonance imaging. JAMA (J Am Med Assoc) 1985; 253: 828. 52. Schenck JF, Hart HR, Foster TH, Edelstein WA, Bottomley PA, Redington RW, Hardy CJ, Zimmerman RA, Bilaniuk LT. Improved MR imaging of the orbit at 1.5T with surface coils. Am. J. of Neuroradiol 1985; 6:193-196. Duplicate publication: Am J Roentgen 1985; 144: 1033-1036.


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53. Bottomley PA. NMR: A new perspective on medicine. NY State J Med 1984; 84: 438-440 (1984). 54. Schenck JF, Foster TH, Henkes JL, Adams WJ, Hayes C, Hart HR, Edelstein WA, Bottomley PA, Wehrli FW. High field surface coil MR imaging of localized anatomy. Am J Neuroradiol 1985; 6: 181-186. 55. Bilaniuk LT, Zimmerman RA, Wehrli FW, Snyder PJ, Goldberg HI, Grossman RI, Bottomley PA, Edelstein WA, Glover GH, MacFall JR, Redington RW. Magnetic Resonance Imaging of Pituitary Lesions Using 1.0 to 1.5 T Field Strength. Radiology 1984; 153: 415-418. 56. Bilaniuk LT, Zimmerman RA, Wehrli FW, Goldberg HI, Grossman RI, Bottomley PA, Edelstein WA, Glover GH, MacFall JR, Redington RW, Kressel HY. Cerebral NMR: Comparison of Low and High Field Strength Imaging. Radiology 1984; 153, 409-414. 57. Bottomley PA, Edelstein WA, Foster TH, Adams WA. In vivo solvent suppressed localized hydrogen nuclear magnetic resonance spectroscopy: a window to metabolism? Proc Natl Acad Sci USA 1985; 82: 2148-2152. 58. Bottomley PA, Redington RW, Edelstein WA, Schenck JF. Estimating RF power deposition in body NMR imaging. Magn Reson Med 1985; 2: 336-349. 59. Zimmerman RA, Bilaniuk LT, Grossman RI, Levine RS, Lynch R, Goldberg HI, Edelstein WA, Bottomley PA, Redington RW. Resistive NMR of intracranial hematomas. Neuroradiol 1985; 27, 16-20. 60. Zimmerman RA, Bilaniuk LT, Grossman RI, Goldberg HI, Edelstein W, Bottomley P, Redington RW. Cerebral NMR: diagnostic evaluation of brain tumors by partial saturation technique with resistive NMR. Neuroradiol 1985; 27, 9-15. 61. Bottomley PA. Non-invasive study of high-energy phosphate metabolism in the human heart

by depth resolved 31P NMR spectroscopy. Science 1985; 229: 769-772. 62. Bottomley PA, Smith LS, Leue WM, Charles HC. Slice interleaved depth resolved surface coil

spectroscopy (SLIT DRESS) for rapid 31P NMR in vivo". J Magn Reson 1985; 64: 347-351. 63. Bottomley PA, Rogers HH, Foster TH. Nuclear magnetic resonance imaging shows water distribution and transport in plant root systems in situ. Proc Natl Acad Sci USA 1986; 83: 87-89. 64. H. H. Rogers, P. A. Bottomley, T. H. Foster. Application of nuclear magnetic resonance imaging to plant root studies". Proceedings of the International Conference on Soil Dynamics, Auburn, Alabama, June 17-19, 1985. Vol 5. Auburn AL: Auburn University 1985: 1152-1157. 65. Bottomley PA, Herfkens RJ, Smith LS, Brazzamano S, Blinder R, Hedlund LW, Swain JL, Redington RW. Noninvasive detection and monitoring of regional myocardial ischemia in situ using depth resolved 31P NMR spectroscopy. Proc Natl Acad Sci USA 1985; 82: 8747-8751. 66. Zimmerman RA, Bilaniuk LT, Yanoff M, Schenck JF, Hart HR, Foster TH, Edelstein WA, Bottomley PA, Redington RW, Hardy CJ. Orbital magnetic resonance imaging. Am J Opthalmology 1985; 100: 312-317. 67. Bottomley PA, Drayer BP, Smith LS. Chronic adult cerebral infarction studied by phosphorus NMR spectroscopy. Radiol 1986; 160: 763-766.

68. Bottomley PA, Hardy CJ, Argersinger RE, Allen-Moore G. A review of 1H NMR relaxation in pathology: are T1 and T2 diagnostic?. Med Phys 1987; 14: 1-37.


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Duplicate publication: General Electric Company Technical Information Series, Report No.86CRD199 (General Electric Corporate Research and Development, Schenectady NY) 1986, p. 1-49. 69. Bottomley PA. Spatial localization in NMR spectroscopy in vivo. Annal NY Acad Sci 1987; 508: 333-348. 70. Bottomley PA, Smith LS, Brazzamano S, Hedlund LW, Redington RW, Herfkens RJ. The fate of

inorganic phosphate and pH in regional myocardial ischemia and infarction: a noninvasive 31P NMR study. Magn Reson Med 1987; 5: 129-142. 71. Bottomley PA, Herfkens RJ, Smith LS, Bashore TM. Altered phosphate metabolism in myocardial infarction detected by P-31 MR spectroscopy. Radiol 1987; 165: 703-707. 72. Rogers HH, Bottomley PA. In situ NMR imaging of roots: influence of soil type, ferromagnetic particle content and soil moisture. Agronomy Journal 1987;79: 957-965. 73. Mueller O, Vatis D, Edelstein W, Bottomley P. RF-technology for NMR imaging/spectroscopy. (Proceedings of the RF Technology Expo '86, Anaheim, CA, Jan. 30-Feb. 1, 1986) RF Design Magazine. Englewood CO: Cardiff 1986, p. 419-432. 74. Bottomley PA, Hardy CJ. Two-dimensional spatially-selective spin inversion and spin echo refocussing with a single Nuclear Magnetic Resonance pulse. J Appl Phys 1987; 62: 4284-4290.

75. Bottomley PA, Hardy CJ. PROGRESS in efficient three-dimensional spatially localized in vivo 31P

NMR spectroscopy using multi-dimensional spatally-selective () pulses. J Magn Reson 1987; 74: 550-556. 76. Hardy CJ, Bottomley PA, O'Donnell M, Roemer P. Optimization of two-dimensional spatially selective NMR pulses by simulated annealing. J Magn Reson 1988;77: 233-250. 77. Hardy CJ, Bottomley PA, Roemer PB. Off-axis spatial localization with frequency modulated nuclear

magnetic resonance rotating () pulses. J Appl Phys 1988; 63: 4741-4743.

78. Bottomley PA, Charles HC, Roemer PB, Flamig D, Engeseth H, Edelstein WA, Mueller OM. Human in

vivo phosphate metabolite imaging with 31P NMR. Magn Reson Med 1988; 7: 319-336.

79. Hardy CJ, Bottomley PA, Roemer PB, Redington RW. Rapid 31P spectroscopy on a 4 Tesla whole-body system. Magn Reson Med 1988; 8: 104-109. 80. Bottomley PA. State of the art. Human in vivo NMR spectroscopy in diagnostic medicine: clinical tool or research probe? Radiology 1989; 170: 1-15. 81. Bottomley PA, Hardy CJ. Rapid, reliable in vivo assays of phosphate metabolites by Nuclear Magnetic Resonance. Clin Chem 1989; 35: 392-395. 82. Bottomley PA, Hardy CJ, Roemer PB, Mueller OM. Proton decoupled, Overhauser enhanced, spatially localized carbon-13 spectroscopy in humans. Magn Reson Med 1989; 12: 348-363. 83. Bottomley PA, Hardy CJ, Roemer PB, Weiss RG. Problems and expediencies in human 31P spectroscopy. The definition of localized volumes, dealing with saturation and the technique-dependence of quantification. NMR in Biomedicine 1989; 2: 284-289. 84. Weiss RG, Bottomley PA, Hardy CJ, Gerstenblith G. Regional myocardial metabolism of high-energy phosphates during isometric exercise in patients with coronary artery disease. N Engl J Med 1990; 323: 1593-1600.


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85. Bottomley PA, Hardy CJ. Roemer, PB. Phosphate metabolite imaging and concentration measurements in human heart by nuclear magnetic resonance. Magn Res Med 1990; 14: 425-434. 86. Bottomley PA, Hardy CJ, Cousins JP, Armstrong M, Wagle WA. AIDS dementia complex: brain high-energy phosphate metabolite deficits. Radiol. 1990; 176: 407-411. 87. Hardy CJ, Cline HE, Bottomley PA. Correcting for nonuniform k-space sampling in two-dimensional NMR selective excitation. J Magn Reson 1990; 87: 639-645. 88. Bottomley PA, Hardy CJ. Strategies and protocols for clinical 31P research in the heart and brain. Phil Trans Roy Soc Lond A 1990; 333: 531-544. 89. Bottomley PA, Hardy CJ, Smith LS, Drayer BP, Cousins JP. Brain high-energy phosphate metabolism in dementias. Bull Clinical Neurosciences 1990 (published 1992); 55: 29-35. 90. Hardy CJ, Bottomley PA. 31P spectroscopic localization using pinwheel NMR excitation pulses. Magn Reson Med 1991; 17: 315-327. 91. Bottomley PA, Weiss RG, Hardy CJ, Baumgartner WA. Myocardial high-energy phosphate metabolism and allograft rejection in patients with heart transplants. Radiol 1991; 181: 67-75. 92. Hardy CJ, Weiss RG, Bottomley PA, Gerstenblith G. Altered myocardial high-energy phosphate metabolites in patients with dilated cardiomyopathy. Am Heart J 1991; 122: 795-801.

93. Bottomley PA, Hardy CJ, Weiss RG. Correcting human 31P heart spectra for partial saturation: Evidence that saturation factors for PCr/ATP are homogeneous in normal and disease states. J Magn Reson 1991; 95: 341-355. 94. Bottomley PA, Weiss RG, Gerstenblith G, Hardy CJ. Regional myocardial metabolism of high-energy phosphates in patients with coronary artery disease (letter). N Engl J Med 1991; 324: 1219. 95. Bottomley PA, Roemer RB. Homogeneous tissue model estimates of RF power deposition in human NMR studies. Local elevations predicted in surface coil decoupling. Annal NY Acad Sci 1992; 649: 144-159. 96. Hardy CJ, Bottomley PA, Rohling KW, Roemer PB. An NMR phased array for human cardiac 31P spectroscopy. Magn Reson Med 1992; 28: 54-64. 97. Bottomley PA, Cousins JP, Pendrey DL, Wagle WA, Hardy CJ, Eames FA, McCaffrey RJ, Thompson DA. Alzheimer's dementia: quantification of energy metabolism and mobile phosphoesters with P-31 NMR spectroscopy. Radiology 1992; 183: 695-699. 98. Bottomley PA, Hardy CJ. Proton Overhauser enhancements in human cardiac phosphorus NMR spectroscopy at 1.5-T. Magn Reson Med 1992; 24: 384-390. 99. Murphy DGM, Bottomley PA, Salerno J, DeCarli C, Mentis M, Grady CL, Giacometti K, Hardy CJ, Schapiro MB, Rapoport SI, Alger J, Horwitz B. An in vivo study of glucose and phosphorus metabolism in Alzheimer's disease using magnetic resonance spectroscopy and positron emission tomography. Archives of General Psychiatry 1993; 50: 341-349. 100. Bottomley PA, Hardy CJ. Mapping creatine kinase reaction rates in human brain and heart with 4 Tesla saturation transfer 31P NMR. J Magn Reson 1992; 99: 443-448.


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101. Bottomley, PA. Brain energy and Alzheimer's disease. General Electric Corporate Research and Development Center Technical Newsletter 1992 (2Q); p1-4. 102. Bottomley, PA, Rogers HH, Prior SA. NMR imaging of root water - distribution in intact Vicia faba L. plants in elevated atmospheric CO2. Plant Cell and Environment 1993; 16: 335-338.

103. Bottomley, PA. The true T1 values of myocardial high-energy phosphates? Magn Reson Med 1993;

29: 145-146. 104. Bottomley PA, Ouwerkerk R. BIRP: an improved implementation of low-angle adiabatic (BIR-4) excitation pulses. J Magn Reson Ser A 1993; 103: 242-244. 105. Bottomley PA, Ouwerkerk R. The dual-angle method for fast sensitive T1 measurement in vivo with

low angle adiabatic pulses. J Magn Reson Ser B 1994; 104:159-167. 106. Bottomley PA. NMR spectroscopy of the human heart: the status and the challenges. Radiology 1994; 191: 593-612. 107. Bottomley PA, Ouwerkerk R. Optimum flip-angles for exciting NMR with uncertain T1 values. Magn

Reson Med 1994; 32: 137-141. 108. Bottomley PA. Whither human cardiac spectroscopy? MAGMA 1994; 2: 169-176. 109. Bottomley PA, Atalar E, Weiss RG. Human cardiac high-energy phosphate metabolite concentrations by 1D-resolved NMR spectroscopy. Magn Reson Med 1996; 35: 664-670. 110. Atalar E, Bottomley PA, Ocali O, Correia LCL, Kelemen MD, Lima JAC, Zerhouni EA. High resolution intravascular MRI and MRS using a catheter receiver coil. Magn Reson Med 1996; 36: 596-605. 111. Bottomley PA, Lugo-Olivieri CH, Giaquinto R. What is the optimum phased-array coil design for cardiac magnetic resonance? Magn Reson Med 1997; 37: 591-599. 112. Bottomley PA, Lee YH, Weiss RG. Total creatine in muscle: imaging and quantification with proton MR spectroscopy. Radiology 1997; 204:403-410. 113. Bottomley PA. The rise of human in vivo NMR spectroscopy. E Raymond Andrew 75th Anniversary Symposium. Solid State Nuclear Magnetic Resonance 1997; 9: 29-40. 114. Conway MA, Bottomley PA, Ouwerkerk R, Radda GK, Rajagopalan B. Mitral Regurgitation: Impaired Systolic Function, Eccentric Hypertrophy, and Increased Severity Are Linked to Lower Phosphocreatine/ATP Ratios in Humans. Circulation 1998; 97: 1716-1723. 115. Bottomley PA, Weiss RG. Noninvasive MRS detection of localized creatine depletion in non-viable, infarcted myocardium. The Lancet 1998; 351: 714-718. 116. Lee RF, Giaquinto R, Constantinides, Souza, S, Weiss RG, Bottomley PA. A broadband phased-array system for direct phosphorus and sodium metabolic MRI on a clinical scanner. Magn Reson Med 2000; 43: 269-277. 117. Constantinides C, Weiss RG, Lee R, Bolar D, Bottomley PA. Restoration of low resolution metabolic images with a priori anatomic information: 23Na MRI in myocardial infarction. Magn Reson Imaging 2000; 18: 461-471.


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118. Constantinides C, Gillen JS, Boada FE, Pomper MG, Bottomley, PA. Human skeletal muscle: 23Na MR imaging and quantification-potential applications in exercise and disease. Radiology 2000; 216: 559-568. 119. Lee RF, Westgate CR, Weiss RG, Bottomley PA. An analytical SMASH procedure (ASP) for sensitivity-encoded MRI. Magn Reson Med 2000; 43: 716-725. 120. Ouwerkerk R, Bottomley PA. On neglecting chemical exchange effects when correcting in vivo 31P MRS for partial saturation. J Magn Reson 2001; 148: 425-435. 121. Bottomley PA, Weiss RG. Noninvasive localized MR quantification of creatine kinase metabolites in normal and infarcted canine myocardium. Radiology 2001; 219: 411-418. 122. Lee RF, Westgate CR, Weiss RG, Newman D, Bottomley PA. The planar strip array (PSA) for parallel spatial encoded MRI. Magn Reson Med 2001; 45: 673-683. 123. Ouwerkerk R, Bottomley PA. On neglecting chemical exchange effects when correcting in vivo 31P MRS for partial saturation: Commentary on: “Pitfalls in the measurement of metabolite concentrationsusing the one-pulse experiment in in vivo NMR”. J Magn Reson 2001; 149: 282-286. 124. Beache GM, Herzka DA, Boxerman JL, Post WS, Gupta SN, Faranesh AZ, Solaiyappan M, Bottomley PA, Weiss JL, Shapiro EP, Hill MN. Attenuated Myocardial Vasodilator Response in Patients With Hypertensive Hypertrophy Revealed by Oxygenation-Dependent Magnetic Resonance Imaging. Circulation 2001; 104: 1214-1217. 125. Constantinides CD, Kraitchman DL, O’Brien K, Boada FE, Gillen J, Bottomley PA. Noninvasive quantification of total sodium concentrations in acute reperfused myocardial infarction using 23Na MRI. Magn Reson Med 2001; 46: 1144-1151. 126. McCaffrey RJ, Cousins JP, Westervelt HJ, Martynowicz M, Remick SC, Szebenyi S, Wagle WA, Bottomley PA, Hardy CJ, Haase RF. Practice effects with the NIMH AIDS abbreviated neuropsychological battery. Arch Clin Neuropsych 1995; 10: 241-250. 127. Constantinides CD, Rogers J, Herzka D, Bolar D, Boada FE, Kraitchman DL, Bottomley PA. Superparamagnetic iron oxide MION as a potential contrast agent for 23Na MRI in myocardial infarction. Magn Reson Med 2001; 46: 1164-1168. 128. Bottomley PA, Ouwerkerk R, Lee RF, Weiss RG. Four angle saturation transfer (FAST) method for measuring creatine kinase reaction rates in vivo. Magn Reson Med 2002; 47: 850-863. 129. Gao F, Bottomley PA, Arnold C, Weiss RG. The effect of orientation on quantification of muscle creatine by 1H MR spectroscopy. Magn Reson Imag 2003; 21: 561-566. 130. Ouwerkerk R, Bleich KB, Gillen JS, Pomper MG, Bottomley PA. Tissue Sodium Concentration In Human Brain Tumors as Measured with 23Na MR Imaging. Radiology 2003; 227:529-537. 131. Lee RF, Hardy CJ, Sodickson DK, Bottomley PA. The Lumped-Element Planar Strip Array (LPSA) for MRI at 1.5T. Magn Reson Med 2004; 51: 172-183. 132. Jacobs MA, Barker PB, Bottomley PA, Bhujwalla Z, Bluemke DA. Proton magnetic resonance spectroscopic imaging of human breast cancer: a preliminary study. JMRI 2004; 19: 68-75. 133. Hardy CJ, Darrow RD, Saranathan M, Giaquinto RO, Zhu Y, Dumoulin CL, Bottomley PA. Large field-of-view real-time MRI with a 32-channel system. Magn Reson Med 2004; 52: 878-884.

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134. Jacobs MA, Ouwerkerk R, Wolff AC, Stearns V, Bottomley PA, Barker PB, Argani P, Khouri N, Davidson NE, Bhujwalla Z, Bluemke DA. Multiparametric and multinuclear magnetic resonance imaging of human breast cancer: current applications. Technology in Cancer Research & Treatment 2004; 3: 543-550. 135. Weiss RG*, Gerstenblith G, Bottomley PA*. ATP Flux through Creatine Kinase in the Normal, Stressed, and Failing Human Heart. Proc Natl Acad Sci USA 2005; 102: 808-813. 136. Ouwerkerk R, Weiss RG, Bottomley PA. Measuring Human Cardiac Tissue Sodium Concentrations Measured Using Surface Coils, Adiabatic Excitation and Twisted Projection Imaging With Minimal T2 Losses. J Magn Reson Imag 2005; 21: 546-555. 137. Najjar SS, Bottomley PA, Schulman SP, Waldron MM, Steffen RP, Gerstenblith G, Weiss RG. Effects of a Pharmacologically-Induced Shift of Hemoglobin-Oxygen Dissociation on Myocardial Energetics during Ischemia in Patients with Coronary Artery Disease. J Cardiovasc MR 2005; 7: 1-10. 138. Gabr RE, Ouwerkerk R, Bottomley PA. Quantifying in vivo MR spectra with circles. J Magn Reson 2006; 179: 152-163. 139. Kumar A, Bottomley PA. Optimizing the Intrinsic Signal-to-noise Ratio of MRI Strip Detectors. Magn Reson Med 2006; 56: 157-166. 140. Smith CS, Bottomley PA*, Schulman SP, Gerstenblith G, Weiss RG*. Altered Creatine Kinase adenosine triphosphate kinetics in failing hypertrophied human myocardium. Circulation 2006; 114:1151-1158. 141. Gabr RE, Aksit P, Bottomley PA, Youssef ABM, Kadah YM. Deconvolution-Interpolation Gridding (DING): Accurate Reconstruction for Arbitrary k-space Trajectories. Magn Reson Med 2006; 56: 1182-1191. 142. Gabr RE, Sathyanarayana S, Schär M, Weiss RG, Bottomley PA. On restoring motion-induced signal loss in single-voxel magnetic resonance spectra. Magn Reson Med 2006; 56: 754-760. 143. El-Sharkawy AM, Sotiriadis P, Bottomley PA, Atalar E. Absolute Temperature Monitoring using RF Radiometry in the MRI Scanner. IEEE Trans Circ Sys 2006; 53: 2396-2405. 144. El-Sharkawy AM, Schär M, Bottomley PA, Atalar E. Monitoring and Correcting Spatial and Temporal Variations of the MR Static Magnetic Field. Magn Reon Mater Phy 2006; 19: 223-236. 145. Ouwerkerk R, Jacobs MA, Macura KJ, Wolff AC, Stearns V, Mezban SD, Khouri NF, Bluemke DA, Bottomley PA. Elevated Tissue Sodium Concentration in Malignant Breast Lesions Detected With Noninvasive 23Na MRI. Breast Cancer Research and Treatment 2007; 2007; 106: 151-160 (DOI 10.1007/s10549-006-9485-4). 146. Aksel B, Marinelli L, Collick BD, Von Morze C, Bottomley PA, Hardy CJ. Local Planar Gradients with Order-of-Magnitude Strength and Speed Advantage. Magn Reson Med 2007; 58: 134-243. 147. Stralka JP, Bottomley PA. A prototype RF dosimeter for independent measurement of the average specific absorption rate (SAR) during MRI. J Magn Reson Imag 2007; 26: 1296-1302. PMC2586170. 148. Kumar A, Bottomley PA. Optimized quadrature surface coil designs. Magn Reon Mater Phy 2008; 21: 41-52 (DOI 10.1007/s10334-007-0090-2). 149. Gabr RE, Weiss RG, Bottomley PA. Correcting reaction rates measured by saturation transfer MRS. J Magn Reson 2008; 191: 248-258.


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150. Ouwerkerk R, Bottomley PA, Solaiyappan M, Spooner A, Tomaselli G, Wu KC, Weiss RG. Tissue sodium concentration in myocardial infarction in humans: A quantitative 23Na MR imaging study. Radiology 2008: 248; 88-96. 151. El-Sharkawy AM*, Qian D*, Bottomley PA. The Performance of Interventional Loopless MRI Antennae at Higher Magnetic Field Strengths. Med Phys 2008; 35: 1995-2006. See also front cover. PMCID: PMC2669652. 152. Jacobs MA, Ouwerkerk R, Kamel I, Bottomley PA, Bluemke DA, Kim HS. Proton, diffusion-weighted imaging, and sodium (23Na) MRI of uterine leiomyomata after MR-guided high-intensity focused ultrasound: a preliminary study. JMRI 2009; 29: 649-656. PMID19243047; NIHMS 103720. 153. Sathyanarayana S, Bottomley PA. MRI endoscopy using intrinsically localized probes. Med Phys 2009; 36: 908-919. PMCID: PMC2673676. 154. El-Sharkawy AEM, Schär M, Ouwerkerk R, Weiss RG, Bottomley PA. Quantitative cardiac 31P spectroscopy at 3T using adiabatic pulses. Magn Reson Med 2009; 61:785-795. NIHMSID # 222446. PMC3084604. 155. Gabr RE, Schär M, Edelstein AD, Kraitchman DL, Bottomley PA, Edelstein WA. MRI Dynamic Range and its Compatibility with Signal Transmission Media. J Magn Reson 2009; 198: 137-145. NIHMS #197555. PMC2873084. 156. Kumar A, Edelstein WA, Bottomley PA. Noise Figure Limits for Circular Loop MR Coils. Magn Reson Med. 2009; 61: 1201-09. PMC2869245. 157. Bottomley PA, Wu KC, Gerstenblith G, Schulman SP, Steinberg A, Weiss RG. Reduced myocardial creatine kinase flux in human myocardial infarction: An in vivo phosphorus magnetic resonance spectroscopy study. Circulation 2009; 119: 1918-24. NIHMSID: 126391 158. Qian D, El-Sharkawy AEM, Atalar E, Bottomley PA. Interventional MRI: Tapering Improves the Forward-Looking Properties of the Loopless Antenna. Magn Reson Med 2010; 63: 797-802. NIHMSID #516242 159. Schär M, El-Sharkawy AEM, Weiss RG, Bottomley PA. Triple Repetition Time Saturation Transfer (TRiST) 31P Spectroscopy for Measuring Human Creatine Kinase Reaction Kinetics. Magn Reson Med 2010; 63: 1493-1501. NIHMSID #225274. 160. Bottomley PA, Kumar A, Edelstein WA, Allen JM, Karmarkar PV. Designing passive MRI-safe implantable conducting leads with electrodes. Med Phys 2010; 37: 3828-3843. 161. Sathyanarayana S, Schär M, Kraitchman DL, Bottomley PA. Towards real-time intravascular endoscopic MRI. J Am Coll Cardiol Img 2010; 3: 1158-1165. (NIHMSID # 251914). See also front cover & Editorials (Lederman RJ, Faranesh AZ, Getting closer for high-resolution vascular MRI. J Am Coll Cardiol Img 2010;3;1166-1167. Kramer CM, Narula J. Whither Catheter-Based Intravascular Magnetic Resonance Imaging of Atherosclerosis? J Am Coll Cardiol Img 2010; 3; 1203-1204.) 162. Ruiz-Cabello J, Barnett BP, Bottomley PA, Bulte JWM. Fluorine (19F) MRS and MRI in Biomedicine. NMR in Biomedicine 2011; 24: 114-129. DOI:10.1002/nbm.1570. NIHMS #260083. PMC3051284. 163. Gabr RE, El-Sharkawy AM, Schär M, Weiss RG, Bottomley PA. High-energy phosphate transfer in human muscle: the diffusion of phosphocreatine. Am J Physiol Cell Physiol 2011; 301: C234-C241 (doi: 10. 1152/ ajpcell. 00500. 2010 2011). NIHMSID # 312498.

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164. Wang G, El-Sharkawy AEM, Edelstein WA, Schar M, Bottomley PA. Measuring T2 and T1, and Imaging T2 without Spin Echoes. J Magn Reson 2012; 214: 273-280 (doi:10.1016/j.jmr.2011.11.016). NIHMS343348. 165. Hirsch GA*, Bottomley PA*, Gerstenblith G, Weiss RG. Allopurinol Acutely Increases ATP Energy Delivery in Failing Human Hearts. J Am Coll Cardiol 2012; 59: 802-808. (See also editorial: Opie LH. Allopurinol for heart failure: Novel mechanisms. J Am Coll Cardiol 2012; 59: 809-812). 166. Qian D, Bottomley PA. High-resolution intravascular magnetic resonance quantification of atherosclerotic plaque at 3T. J Cardiovasc Magn Reso 2012: 14:20. doi:10.1186/1532-429X-14-20. PMC3340302. 167. Erturk MA*, El-Sharkawy AM*, Bottomley PA. Interventional Loopless Antenna at 7 Tesla. Magn Reson Med 2012; 68: 980-988. DOI: 10.1002/mrm.23280. NIHMS331617; PMC3374912. 168. Zhang Y, Gabr R, Schär M, Weiss RG, Bottomley PA. Magnetic resonance spectroscopy with linear algebraic modeling (SLAM) for higher speed and sensitivity. J Magn Reson 2012: 218; 66-76. 10.1016/j.jmr.2012.03.008. PMC3381802 169. El-Sharkawy AEM, Qian D, Bottomley PA, Edelstein WA. A Multichannel, Real-Time MRI RF Power Monitor for Independent SAR Determination. Med Phys 2012; 39: 2334-2341. PMC3338589. 170. Erturk MA, Bottomley PA El-Sharkawy AEM. De-Noising MRI Using Spectral Subtraction. IEEE Trans Biomed Eng 2013; 60: 1556-1562. PMID23322757. 171. Abraham MR*, Bottomley PA*, Dimaano VL, Pinheiro A, Steinberg A, Traill TA, Abraham TP, Weiss RG. Creatine kinase adenosine triphosphate and phosphocreatine energy supply in a single kindred of patients with hypertrophic cardiomyopathy. Am J Cardiol 2013; 112: 861-866. (DOI: 10.1016/j.amjcard.2013.05.017). PMC3759602. 172. El-Sharkawy AEM, Gabr RE, Schär M, Weiss RG, Bottomley PA. Quantification of human high-energy phosphate metabolite concentrations at 3T with partial volume and sensitivity corrections. NMR Biomed. 2013; 26: 1363–1371 (DOI: 10.1002/nbm.2961). 173. Zhang Y, Gabr R, Zhou J, Weiss RG, Bottomley PA. Highly-accelerated quantitative 2D and 3D localized spectroscopy with linear algebraic modeling (SLAM) and sensitivity encoding. J Magn Reson 2013: 237; 125-138. PMC3976201. 174. Qian D, El-Sharkawy AM, Bottomley PA, Edelstein WA. An RF dosimeter for independent SAR measurement in MR scanners. Med Phys 2013; 40, 122303; doi: 10.1118/1.4829527 175. Bottomley PA*, Panjrath GS*, Lai S, Hirsch GA, Wu K, Najjar SS, Steinberg A, Gerstenblith G Weiss RG. Metabolic Rates of ATP Transfer Through Creatine Kinase (CK flux) Predict Clinical Heart Failure Events and Death. Science Transl Med 2013; 5: 215re3, pp1-8. DOI: 10.1126/scitranslmed.3007328. PMC4440545, NIHMS689598 176. Wang G, El-Sharkawy AEM, Bottomley PA. Minimum Acquisition Methods for Simultaneously Imaging T1, T2, and Proton Density with B1 correction and no spin-echoes. J Magn Reson 2014; 242: 243-255. 177. Erturk MA, El-Sharkawy AEM, Moore J, Bottomley PA. 7 Tesla MRI with a Transmit/Receive Loopless Antenna and B1-Insensitive Selective Excitation. Magn Reson Med 2014; 72: 220-226. DOI: 10.1002/mrm.24910.


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178. Owens S, Erturk MA, Murphy JD, Wu CL, Bottomley PA. Evaluation of Epidural and Peripheral Nerve Catheter Heating during Magnetic Resonance Imaging Procedures. Regional Anesthesia Pain Med 2014; 39. DOI: 10.1097/AAP.0000000000000151. 179. Erturk MA, El-Sharkawy AEM, Bottomley PA. Monitoring Local Heating Around an Interventional MRI Antenna with RF Radiometry. Med Phys 2015; 42, 1411. DOI: 10.1118/1.4907960. 180. Zhang Y, Zhou J, Bottomley PA. Minimizing lipid signal bleed in brain 1H chemical shift imaging by post-acquisition grid shifting. Magn Reson Med 2015; 74: 320-329. DOI 10.1002/mrm.25438. 181. Hegde SS, Zhang Y, Bottomley PA. Acceleration and motion-correction techniques for high-resolution intravascular MRI. Magn Reson Med 2015; 74: 452-461. DOI: 10.1002/mrm.25436. NIHMSID # 622111. 182. Bottomley PA. Sodium MRI in human heart: a review. NMR in Biomedicine 2015; 29: 187-196. DOI: 10.1002/nbm.3265. 183. Weiss K, Bottomley PA, Weiss RG. On the theoretical limits of detecting cyclic changes in cardiac high-energy phosphates and CK reaction kinetics using in vivo 31P MRS. NMR in Biomed 2015; 28: 694-705. 184. Schär M, Gabr RE, El-Sharkawy AEM, Steinberg A, Bottomley PA, Weiss RG. Two Repetition Time Saturation Transfer (TwiST) with Spill-over Correction to Measure Creatine Kinase Reaction Rates in Human Hearts. J Cardiovasc Magn Reson. 2015; 17: 70. DOI 10.1186/s12968-015-0175-4. 185. Zhang Y, Heo HY, Jiang S, Lee D-H, Bottomley PA, Zhou J. Highly Accelerated Chemical Exchange Saturation Transfer (CEST) Measurements with Linear Algebraic Modeling. Magn Reson Med 2016; Jul; 76(1):136-44. DOI 10.1002/mrm.25873. PMC4548835. 186. Erturk MA, Hegde SS, Bottomley PA. Radiofrequency ablation, MR thermometry, and high-resolution MR parametric imaging with a single, minimally-invasive device. Radiology 2016; 281: 927-932. DOI: http://dx.doi.org/10.1148/radiol.2016151447. NIHMS819575 187. Weiss K, Schär M, Panjrath GS, Zhang Y, Sharma K, Bottomley PA, Golozar A, Steinberg A, Gerstenblith G, Russell SD, Weiss RG. Fatigability, exercise intolerance, and abnormal skeletal muscle energetics in heart failure. Circ Heart Fail. 2017; 10:e004129. DOI: 10.1161/CIRCHEARTFAILURE.117.004129. 188. Zhang Y, Heo HY, Lee DH, Jiang S, Zhao X, Bottomley P, Zhou J. Chemical Exchange Saturation Transfer (CEST) Imaging with Fast Variably-accelerated Sensitivity Encoding (vSENSE). Magn Reson Med 2017; 77: 2225-2238. DOI 10.1002/mrm.26307. 189. Zhang Y, Liu X, Zhou J, Bottomley PA. Ultrafast compartmentalized relaxation time mapping with linear algebraic modeling. Magn Reson Med 2018; 79:286–297 DOI 10.1002/mrm.26675. PMC5636648. 190. Wang G, Zhang Y, Hegde SS, Bottomley PA. High-resolution and accelerated multi-parametric mapping with automated characterization of vessel disease using intravascular MRI. J Cardiovasc Magn Reson 2017; 19:89 DOI 10.1186/s12968-017-0399-6. PMC5694914. 191. Gabr RE, El-SharkawyAEM, Schar M, Panjrath GS, Gerstenblith G, Weiss RG, Bottomley PA. Cardiac work is related to creatine kinase energy supply in human heart failure: a cardiovascular magnetic resonance spectroscopy study. J Cardiovasc Magn Reson 2018; 20:81. doi.org/10.1186/s12968-018-0491-6. PMC6287363. PMID:30526611 192. Solaiyappan M, Weiss RG, Bottomley PA. Neural-network classification of cardiac disease from 31P MRS measures of creatine kinase energy metabolism. J Cardiovasc Magn Reson 2019; 21: 49.

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193. Zhang Y, Heo H-Y, Jiang S, Zhou J, Bottomley PA. Fast 3D Chemical Exchange Saturation Transfer (CEST) Imaging with Variably-accelerated Sensitivity Encoding (vSENSE). Magn Reson Med 2019. DOI: 10.1002/mrm.27881. 194. Liu X, Ellens N, Williams, Burdette C, Karmarkar P, Weiss CR, Kraitchman D, Bottomley PA. High-resolution Intravascular MRI-guided Perivascular Ultrasound Ablation. Magn Reson Med 2019; 83: 240-253. DOI: 10.1002/mrm.27932. NIHMS1042696 XXX *Authors designated as contributing equally to the work.

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BOOK CHAPTERS 1. Bottomley PA. Medical and biological applications of NMR. In: Partain CL, Price RR, Rollo FD, James AE, eds. Nuclear Magnetic Resonance (NMR) imaging. Philadelphia: W.B. Saunders 1983: Ch 27, p. 375-382. 2. Smith LS, Bottomley PA, Edelstein WA, Hart HR, Redington RW, Schenck JF. NMR imaging techniques and applications". In: Rao DV, Chandra R, Grapham MC, eds. Physics of nuclear medicine, recent advances. New York: AIP 1984, pp 518-538. 3. Alavi A, Leonard J, Chawluk J., Zimmerman RA, Dann RW, Alavi J, Edelstein W, Bottomley P, Redington R, Reivich M. Correlative studies of the brain with positron emission tomography (PET), nuclear magnetic resonance (NMR), and x-ray computed tomography (XCT). In: Hartmann A, Hoyer S, eds. Cerebral Blood Flow and Metabolism Measurement. Heidelberg: Springer-Verleg 1985, pp 523-539. 4. Bottomley PA. High field NMR imaging and spectroscopy. In: Bradbury EM, Nicolini C, eds. NMR in the Life Sciences. NATO Advanced Study Institute Series A: Life Sciences. New York: Plenum 1986, pp 223-234. 5. Bottomley PA. The frequency dependence of proton NMR relaxation times in biological tissue. In: Partain C.L., Price RR, Patton J. A., Kulkani M.V. James A.E. eds. Magnetic Resonance Imaging, 2nd edition. Vol. II, Philadelphia: W.B. Saunders 1988, Ch. 66, p.1075-1098. 6. Bottomley PA. A practical guide to getting NMR spectra in vivo. In: Budinger TF, Margulis AR eds. Medical magnetic resonance imaging and spectroscopy, a primer. Berkeley CA: Society for Magnetic Resonance in Medicine 1986, pp 81-95. 7. Bottomley PA. Depth resolved surface coil spectroscopy (DRESS). In: Diehl P, Fluck E, Gunther H, Kosfeld R, Seelig J, eds. NMR basic principles and progress. Vol. 27. In vivo magnetic resonance spectroscopy II: Localization and Spectral Editing. Berlin Germany: Springer 1992, pp 67-102. 8. Bottomley PA. Instrumentation and strategies for in vivo human cardiac phosphorus NMR spectroscopy. In: Schaefer S, Balaban RS, eds. Cardiovascular magnetic resonance spectroscopy. Norwell MA: Kluwer Academic 1992, pp 25-43. 9. Bottomley PA, Hardy CJ, Weiss RG. Quantitative NMR spectroscopy of human heart. In: Pohost GM, ed. Cardiovascular Applications of Magnetic Resonance Imaging and Spectroscopy. Mount Kisco NY: Futura 1993, Ch 28, p. 349-362. 10. Bottomley PA. The development of high-field NMR imaging: 0.12 T to 1.5 T. In: Grant DM, Harris RK, eds. Encyclopedia of NMR. Chichester: Wiley, 1995.


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11. Bottomley PA. Heart studies using MRS. In: Grant DM, Harris RK, eds. Encyclopedia of NMR. Chichester: Wiley 1995, pp 2284-2292. 12. Bottomley PA. Human cardiac NMR spectroscopy. In: Young IR, Charles C, eds. MR spectroscopy: clinical applications and techniques. London: Martin Dunitz 1996, pp 75-91. 13. Weiss RG, Bottomley PA. Cardiac magnetic resonance spectroscopy: principles and applications. In: Skorton DJ, Schelbert HR, Wolf GL, Brundage BH, eds. Marcus Cardiac Imaging, 2nd edition. Philadelphia PA: W.B.Saunders 1996; Ch 51; 784-791. 14. Bottomley PA. MRS of the human heart. Syllabus, International Society for Magnetic Resonance in Medicine (ISMRM) introductory spectroscopy course, 6th Scientific Meeting, Sydney Australia, April 19, 1998. ISMRM, Berkeley 1998; 357-364. 15. Bottomley PA. Quantification of myocardial phosphorus magnetic resonance spectroscopy in humans. In: Higgins CB, Ingwall JS, Pohost GM, eds. Current and future applications of magnetic resonance in cardiovascular disease. American Heart Association Monograph Series. Armonk NY: Futura 1998; Ch 23: 405-420. 16. Bottomley PA. Clinical MRS of nuclei other-than-hydrogen. Syllabus, International Society for Magnetic Resonance in Medicine (ISMRM), 7th Scientific Meting, Philadelphia, PA, May 22-28, 1999. ISMRM, Berkeley 1999; 221-228. 17. Bottomley PA, Lardo AC, Tully S, Karmarker P, Viohl I. Safety and internal MRI coils. 2001 Syllabus. Special cross-specialty categorical course in Diagnostic Radiology: practical MR safety considerations for physicians, physicists, physicists and technologists, Oak Brook IL: Radiological Society of North America 2001; 85-90. (Abstract: Radiology 2001; 221(P): 75). 18. Weiss RG, Bottomley PA, R Kahlil-Filho. Cardiac magnetic resonance spectroscopy. In: Manning WJ, Pennel DJ, Cardiovascular Magnetic Resonance, New York: Churchill Livingstone 2002; Ch 33: 437-446. 19. Weiss RG, Hirsch GA, Bottomley PA. Cardiac magnetic resonance spectroscopy. In: Kwong, Raymond Y. Contemporary Cardiology: Cardiovascular Magnetic Resonance Imaging. Humana press, Totowa NJ 2007; Ch 30: pp 663-684. 20. Bottomley PA. NMR Spectroscopy of the Human Heart. In: Encyclopedia of Magnetic Resonance, eds R. K. Harris and R. E. Wasylishen, John Wiley: Chichester. DOI: 10.1002/9780470034590.emrstm0345.pub2. Published 15th September 2009. 21. Bottomley PA. Sodium MRI in Man: Technique and Findings. In: Encyclopedia of Magnetic Resonance, eds R. K. Harris and R. E. Wasylishen, John Wiley: Chichester. DOI: 10.1002/9780470034590.emrstm1252. Published 15th March 2012 (emrstm1252). eMagRes, 2012, Vol 1: 353–366. DOI 10.1002/9780470034590.emrstm1252. 22. Bottomley PA, Zhang Y. Accelerated Spatially Encoded Spectroscopy of Arbitrarily Shaped Compartments Using Prior Knowledge and Linear Algebraic Modeling. eMagRes 2015; 4: 89–104. DOI 10.1002/9780470034590.emrstm1438. 23. Bottomley PA. The Basics. eMagRes, 2015, Vol 4: 505–524. DOI 10.1002/9780470034590.emrstm1485. 24. Bottomley PA. Quantifying metabolite ratios and concentrations by non-1H MRS. eMagRes, 2015, Vol 4: 611–626. DOI 10.1002/9780470034590.emrstm1486. 25. Bottomley PA. Measuring biochemical reaction rates in vivo with magnetization transfer. eMagRes, 2016, Vol 5: 843–858. DOI 10.1002/9780470034590.emrstm1487.


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26. Bottomley PA. MRS Studies of Creatine Kinase Metabolism in Human Heart. eMagRes, 2016, Vol 5: 1183–1202. DOI 10.1002/9780470034590.emrstm1488. 27. Weiss RG, Gupta A, Bottomley PA. MRS in the Failing Heart: From Mice to Humans. eMagRes, 2016, Vol 5: 1271–1282. DOI 10.1002/9780470034590.emrstm1466. 28. Bottomley PA. On the Origins of Localized NMR: view from an accomplice. In: Bydder GM, Young IR, Paley M, eds. The Development of Magnetic Resonance Imaging and Spectroscopy, MRIS History UK. https://mrishistory.org.uk. 2019; Vol.1 (pp 56). XXX

___________________________________ EDITORIALS 1. Bottomley PA. “Book Review: Nuclear magnetic resonance imaging in medicine, Kaufman L, Crooks LE, and Margulis AR, eds.” J Am Med Assoc 1982; 247: 3362. 2. Bottomley PA, Edelstein WA. "Magnetic resonance without nuclei?" Am J Roentgen 1984; 143: 197-198. Duplicate publication: Am J Neuroradiol 1984. Duplicate publication: Edelstein WA, Bottomley PA. "Magnetic resonance without nuclei?" Radiol 1984; 152: 237-238. 3. Bottomley PA. Nuclear magnetic resonance spin-offs. Physics Today 1987; 40: S53-S54. 4. Bottomley PA. “Book Review: Physics in Medicine and Biology Encyclopedia: Medical Physics, Bioengineering, and biophysics, edited by T. F. McAinsh (Pergamon New York 1986)". J Am Med Assoc 1987; 257: 2222 (1987). 5. Bottomley PA, Hardy CJ. Reply to comments of Akber. Med Phys 1987; 14: 1091. 6. Bottomley PA. "Overview-SMRM 1987. Instrumentation". Society Magnetic Resonance in Medicine Newsletter (SMRM, Berkeley, CA) 1987 (Fall); 13: 5. 7. Bottomley PA. The trouble with spectroscopy papers. Radiology 1991; 181: 344-350. Duplicate publication: J Magn Reson Imaging 1992; 2: 1-8. 8. Bottomley PA. Proton MR spectroscopy for diagnosing hepatic encephalopathy? Radiology 1992; 182: 6-7. 9. Balaban R, Bottomley PA, Brown TR, Gadian D, Mountford C, Radda GK, Ross BD, Shulman RG, Springer C, Ugurbil K. “Advances in physiological chemistry by in vivo NMR (meeting report).” Magn Reson Med 1995; 34: 289-292. 10. Bottomley PA, Mansfield P, Allen PS. In memoriam. E Raymond Andrew, June 27, 1921-May 26, 2001. Magn Reson Med 2001; 46: 417-418. Duplicate publication: The Independent (national newspaper, UK) Thurs July 26 2001: 6. 11. Bottomley PA. Turning up the heat on MRI. J Am Coll Radiol 2008: 853-855. NIHMSID # 251921. 12. Gabr RE, Weiss RG, Bottomley PA. Erratum to “Correcting reaction rates measured by saturation-transfer magnetic resonance spectroscopy” [J. Magn. Reson. 191 (2008) 248–258]. J Magn Reson 2012; 217: 112.

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13. Bottomley PA. In Memoriam: William A Edelstein, 1944–2014. Magn Reson Med 2014; 72: 201-303. Also: http://ismrm.org/Memoriam/edelstein.htm. 14. Bottomley PA, Maudsley AA. In Memoriam: Sir Peter Mansfield. Radiology 2017; 284: 305-306. XXX

________________________________________________ ABSTRACTS 1. Andrew ER, Bottomley PA, Hinshaw WS, Holland GN, Moore WS, Simaroj C. Image formation by NMR". In: the British Biophysical Society Meeting on NMR, Oxford, UK, 27-30 March 1977, abstracts. 2. Bottomley PA. RF magnetic field attenuation in biological tissue: Its relevance to NMR imaging. In: the British Radio-spectroscopy Group Meeting on Biological Applications of NMR, Dundee, UK, 14-15 September 1977, book of abstracts. p. E2. 3. Hinshaw WS, Andrew ER, Bottomley PA, Holland GN, Moore WS, Worthington BS. Display of cross-sectional anatomy by nuclear magnetic resonance imaging. Proceedings Anatomical Society of Great Britain, Nottingham, UK, 5-6 January 1978. J Anat 1978; 126(2): 440. 4. Hinshaw WS, Andrew ER, Bottomley PA, Holland GN, Moore WS, Worthington BS. Internal morphological analyses by NMR imaging. British Institute Radiology and Royal College of Radiology and the Radiological Society of the Netherlands Annual Congress, London, April 13-14, 1978. Brit J Radiol 1979; 52: 349. 5. Andrew ER, Bottomley PA, Hinshaw WS, Holland GN, Moore WS, Simaroj C, Worthington BS. NMR imaging in biological systems. In: the VIII International Conference on Magnetic Resonance in Biological Systems, Nara, Japan, Sept 11-14, 1978, book of abstracts. Nara: International Conference on Magnetic Resonance in Biological Systems, 1978, p.144. 6. Hinshaw WS, Andrew ER, Bottomley PA, Holland GN, Moore WS, Worthington BS. In vivo display of macroscopic structures by NMR. Meeting of the British Association of Clinical Anatomists, Nottingham, UK, Sept 28 1978. Annal Roy Coll Surgeons 1979; 61: 154. 7. Hinshaw WS, Andrew ER, Bottomley PA, Holland GN, Moore WS, Worthington BS. The mapping of internal structures by nuclear magnetic resonance. The Annual Congress of the Irish College of Radiologists, Dublin, Eire, 5-6 October, 1978, abstracts. 8. Andrew ER, Bottomley PA, Hinshaw WS, Holland GN, Moore WS, Simaroj C, Worthington BS. NMR imaging at intermediate sizes. Joint Meeting of the British Institute of Radiology, the Institute of Electrical Engineering, and the Institute of Electrical and Radio Engineers, London, Nov 16 1978. Brit J Radiol 1979; 52: 680. 9. Bottomley PA. In-vivo imaging of healthy and tumour issue by NMR. In: Program and Abstracts Abstracts, 21st Experimental NMR Conference Tallahassee, FL, March 16-20, 1980. Tallahassee FL: ENC Inc, 1980 p. H4. 10. Bottomley PA. Nuclear magnetic resonance imaging: some results and applications. In: American College of Radiology Conference on Current Developments in Medical Imaging, an Evaluation, Colorado Springs, USA, 5-7 August 1980. 11. Bottomley PA, Nunnally RL. 31P NMR studies of the metabolism of perfused hearts: new methods for assessing drug therapy". Proceedings, Joint ISMAR-Ampere Conference on Magnetic Resonance, Delft, the Netherlands, 25-29 August 1980. Bull Magn Reson 1981; 2: 423-424.

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12. Bottomley PA. In-vivo discrimination of normal and neoplastic tissues in rats by proton NMR imaging. In: 9th International Conference on Magnetic Resonance in Biological Systems, Abstracts, Bendor, France, Sept 1-6 1980. Bendor: 9th International Conference on Magnetic Resonance in Biological Systems, 1980 p. 170. 13. Bottomley PA. NMR imaging: some potential applications. Nuclear Magnetic Resonance Imaging Symposium, Nashville, USA, 26-27 October, 1980. J Comp Assist Tomogr 1981; 5: 292-295.

14. Nunnally RL, Bottomley PA. Myocardial ischemia and its response to drug therapies: localized 31P NMR metabolic studies using surface coils. Nuclear Magnetic Resonance Imaging Symposium, Nashville, USA, 26-27 October, 1980. J Comp Assist Tomogr 1981; 5: 296-298. 15. Bottomley PA. NMR instrumentation. In: Program and Syllabus, Workshop on Nuclear Magnetic Resonance, Houston, 19-20 February 1981. Houston TX: University of Texas Medical School at Houston, 1981 p. 3.1-3.4. 16. Bottomley PA, Edelstein WA. Magnetic field exposure in clinical nuclear magnetic resonance imaging. In: Wackenheim A, ed. Proceedings of the XVth International Congress of Radiology, Brussels, Belgium, 24 June-July 1, 1981. Luxembourg: Interimages, 1981, pp 412-414. 17. Edelstein WA, Bottomley PA, Hart HR, Leue WM, Smith LS, Schenck JF, Redington RW. Signal noise and contrast in NMR imaging. In: Scientific Program, Society of Magnetic Resonance in Medicine 1st Annual Meeting, Boston, MA, Aug. 16-18, 1982. Berkeley CA: Society of Magnetic Resonance in Medicine, 1982 p. 52-53. 18. Edelstein WA, Bottomley PA, Leue WM, Hart HR, Schenck JF, Redington RW. NMR imaging methods and artifact removal. Society of Nuclear Medicine 29th Annual Meeting, June 15-18, 1982. J Nucl Med 1982; 23: 38. 19. Bottomley PA. Medical imaging by nuclear magnetic resonance. In: Society for magnetic Resonance Imaging, first annual meeting, Program and Abstracts, Feb. 14-18, 1983, Colorado Springs CO. McClean VA: Society for magnetic Resonance Imaging, 1983. 20. Bottomley, PA, Hart HR, Edelstein WA, Schenck JF, Smith LS, Mueller O, Vatis D, and Redington RW. Head imaging and spectroscopy at 1.5 Tesla. In: Society for magnetic Resonance Imaging, first annual meeting, Program and Abstracts, Feb. 14-18, 1983, Colorado Springs CO. McClean VA: Society for magnetic Resonance Imaging, 1983. 21. Schenck JF, Hart HR, Bottomley PA, Edelstein WA, Hussain MA, Redington RW. NMR imaging at very high fields: issues and theories, results and conjectures. In: Society for magnetic Resonance Imaging, first annual meeting, Program and Abstracts, Feb. 14-18, 1983, Colorado Springs CO. McClean VA: Society for magnetic Resonance Imaging, 1983. 22. Bottomley PA, Smith LS, Edelstein WA, Hart HR, Mueller OM, Leue WM, Darrow R, Redington RW, 1983. Localized 31P, 13C, and 1H NMR spectroscopy studies of the head and body at 1.5 Tesla. Society of Magnetic Resonance in Medicine 2nd Annual Meeting, San Francisco, CA, Aug. 16-18, 1983. Magn Reson Med 1984; 1: 111-112. 23. Bottomley PA, Edelstein WA, Hart HR, Schenck JF, Smith LS, Leue WM, Mueller OM, Redington RW. In vivo 1H imaging of the head at 1.5 tesla. Society of Magnetic Resonance in Medicine 2nd Annual Meeting, San Francisco, CA, Aug. 16-18, 1983. Magn Reson Med 1984; 1: 113-114. 24. Edelstein WA, Mueller OM, Bottomley PA, Hart HR, Schenck JF, Smith LS, O'Donnell M, Leue WM, Redington RW. NMR images of the whole human trunk at 64 MHz. Society of Magnetic Resonance in Medicine 2nd Annual Meeting, San Francisco, CA, Aug. 16-18, 1983. Magn Reson Med 1984; 1: 145.


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25. Edelstein WA, Bottomley PA, Pfeifer LM. A signal-to-noise calibration procedure for NMR imaging systems. Society of Magnetic Resonance in Medicine 2nd Annual Meeting, San Francisco, CA, Aug. 16-18, 1983. Magn Reson Med 1984; 1: 145-146. 26. Zimmerman RA, Bilaniuk LT, Levine RS, Redington RW, Edelstein WA, Bottomley PA, Smith LS. Cerebral NMR: comparison of high and low field strengths. Radiol 1983; 149(P): 97. 27. Kressel HY, Axel L, Kundel HL, Baum S, Edelstein W, Bottomley P, Hart H, Redington RW. Nuclear magnetic resonance proton imaging of the thorax and abdomen at high (1.0-1.5 T) and low (0.12 T) field strengths. Radiol 1983; 149(P): 124. 28. Bilaniuk LT, Zimmerman RA, Grossman RI, Goldberg HI, Packer R, Sutton LN, Lynch R, Redington RW, Edelstein WA, Bottomley PA, Smith S. Cerebral NMR of pediatric brain tumors. Radiol 1983; 149 (P): 178. 29. Bottomley PA, Foster TH, Argersinger R, Pfeifer LM. Hydrogen NMR relaxation times in normal tissue as a function of tissue type, NMR frequency, temperature, species, excision, and age. Society Magnetic Resonance Imaging 2nd annual meeting, Feb. 25-March 2, 1984, Orlando. Magn Reson Imag 1984; 2: 235. 30. Bottomley PA, Edelstein WA, Schenck JF. High resolution anatomy and metabolism of the head studied by high field NMR. In: Abstracts of the 1984 Neuroradiology Conference, Tokyo, Japan, Feb. 25, 1984. 31. Bottomley PA. NMR in diagnostic medicine. I. A review of NMR imaging techniques, pulse sequences, and in vivo NMR spectroscopy. II. A review of normal tissue hydrogen NMR relaxation times and relaxation mechanisms as a function of tissue type, NMR frequency, temperature, species, excision, and age. In: National Cancer Institute Symposium on Research and Chemical Applications of NMR in Cancer, New Orleans, June 20-22, 1984, Program and Abstracts of Papers. New Orleans: Organ Systems Program of the National Cancer Institute, 1984 P1-3. 32. Bottomley PA "RF power deposition in NMR imaging. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1984. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1984, p. 63-65.

33. Bottomley PA. A review of relaxation mechanisms and models for normal tissue 1H NMR relaxation from 1-100 MHz. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1984. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1984, p. 66-67. 34. Bottomley PA, Edelstein WA, Leue WM, Redington RW, Schenck JF, Foster TH, Smith LS. Technical feasibility of clinical 1H imaging and 31P spectroscopy. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1984. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1984, p. 68-69.

35. Bottomley PA, Foster TH, Argersinger RE, Pfeifer LM. A Review of Normal 1H NMR Relaxation Times from 1-100 MHz: Dependence on Tissue Type, NMR Frequency, Temperature, Species, Excision, and Age. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1984. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1984, p. 70-71. 36. Bottomley PA, Foster TH, Leue WM, 1H chemical shift imaging of the brain. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1984. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1984, p. 72-73. 37. Bottomley PA, Foster TH, Darrow RD. Depth resolved surface coil spectroscopy (DRESS) for in vivo 1H, 31P, and 13C NMR. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1984. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1984, p. 74-75.


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38. Bottomley PA, Budinger TF, eds. Proceedings of a Workshop on RF coil energy deposition in NMR, San Francisco, CA, Nov. 7, 1984. 39. Bottomley PA. RF power deposition in body NMR imaging: comparison of experiment and theoretical model estimates. In: Bottomley PA, Budinger TF, eds. "Proceedings of a Workshop on RF coil energy deposition in NMR, San Francisco, CA, Nov. 7, 1984. 40. Bottomley PA. Chemical shift imaging techniques and applications. In: Abstracts of Symposium on spectroscopy and other nuclei at the 3rd Ann. Meeting of the Soc. Magn. Reson. Imag., San Diego, CA March 22-26, 1985. McLean Va: Society of Magnetic Resonance Imaging, 1985. 41. Bottomley PA, Hardy CJ, Argersinger RE, Allen GR. A review of pathological tissue 1H NMR relaxation times from 1-100 MHz. 3rd annual meeting Soc. Magn. Reson. Imag. San Diego, CA, March 22-26, 1985. Magn Reson Imag 1985; 3, 186. 42. Bottomley PA, Hardy CJ, Argersinger RE, Allen GR. A review of pathological tissue 1H NMR relaxation times from 1-100 MHz. In: Allen PS, Boisvert DPJ, Lentle BC, eds. Magnetic resonance in cancer, proceedings of an international conference on magnetic resonance in Cancer, Banff, Alberta April 30-May 4 1985. Toronto, Canada: Pergamon,1985 p 45-46. 43. Bottomley PA, Hardy CJ, Argersinger RE, Allen GR. Relaxation in pathology: are T1's and T2's

diagnostic? In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1985. Vol. 1. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1985, p. 28-29. 44. Bottomley PA. Towards clinical 31P spectroscopic imaging. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1985. Vol. 1. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1985, p. 125-126. 45. Bottomley PA, Herfkens R, Smith LS, Brazzamano S, Blinder R, Hedlund L, Redington RW Noninvasive detection of metabolic impairment in regionally ischemic hearts in situ using depth resolved surface coil spectroscopy (DRESS). In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1985. Vol. 1. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1985, p. 447-448. 46. Bottomley PA, Smith LS, Leue WM, Charles C. Slice interleaved depth resolved surface coil spectroscopy (SLIT DRESS) for rapid 31P NMR in vivo. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1985. Vol. 2. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1985, p. 946-947. 47. Bottomley P.A., Techniques and applications of NMR chemical shift imaging in vivo. In: 24th Eastern Analytical Symposium, New York, NY, Nov. 19-22, 1985, official program. Montchanin DE: Eastern Analytical Symposium Inc, 1985 p. 176. 48. Rogers HH, Bottomley PA, Foster TH, Johnson FA. In situ root imaging with nuclear magnetic resonance. Proceedings Annual Meeting American Society of Agronomy, The Crop Science Society of America & the Soil Science Society of America, Chicago, IL, Dec. 1-6, 1985. Agronomy Abstracts 1985; p87. 49. Rogers H. H., Bottomley P.A. Proton NMR imaging of roots within soil Abstracts of the Proceedings of the 1986 AAAS Annual Meeting, Philadelphia, PA, 25-30 May 1986. Washington, DC: AAAS, 1986, p150. 50. Bottomley PA, Hardy CJ, Argersinger RE. The field dependence of T1 contrast between normal and pathological tissue: a review. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1986. Vol. 2. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1986, p. 407-408.


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5l. Bottomley PA, Smith LS, Herfkens RJ, Bashore TM, Utz JA. Detecting human myocardial infarction with localized 31P NMR: Characterization of normal and ischemic tissue. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1986. Vol. 3. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1986, p. 606-607. 52. Bottomley PA, Smith LS, Brazzamano S, Hedlund L, Redington RW, Herfkens RJ. The fate of Pi and pH in regional myocardial infarction: a noninvasive 31P NMR study. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1986. Vol. 3. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1986, p. 608-609. 53. Bottomley PA, Drayer BP, Smith LS. Phosphate metabolism in chronic adult cerebral infarction" In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1986. Vol. 4. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1986, p. 1345-1346. 54. Smith LS, Bottomley PA, Drayer BP, Herfkens RJ. Localized clinical 31P NMR spectroscopy in Huntington's, Parkinson's, Alzheimer's, and Binswanger's diseases. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1986. Vol. 4. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1986, p. 1386-1387. 55. Herfkens RJ, Bottomley P, Smith S, Bashore T, Utz JA, Redington R. P-31 spectroscopy of human myocardial infarction. Radiol 1986; 161(P): 81. 56. Bottomley PA. Noninvasive NMR studies phosphate metabolism in heart. Biomedicine & Pharmacotherapie 1986; 40: 357. 57. Bottomley PA, Herfkens RJ, Smith LS, Bashore TM. Localized 31P NMR spectroscopy in normal and infarcted human heart. 5th Annual Meeting, Soc. Magn. Reson. Med., San Antonio, TX, Feb. 28-March 4, 1987. Magn Reson Imag 1987; 5 (S1): 42.

58. Bottomley PA. State-of-the-art of clinical 31P NMR spectroscopy in human disease. 5th Annual Meeting. Magn. Reson. Med., San Antonio, TX, Feb. 28-March 4, 1987. Magn Reson Imag 1987; 5 (S1): 129. 59. Bottomley, PA. Relaxation measurements and tumors. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1987. Vol. 1. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1987, p. 70.

60. Bottomley, PA, Hardy CJ, Leue WM. 2-D spatially selective excitation with a single NMR () pulse:

PROGRESS in 3-D localized 31P spectroscopy and surface coil imaging. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1987. Vol. 1. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1987, p. 133. 61. Hardy, CJ, O'Donnell M, Bottomley PA, Roemer, PB. Optimization of 2-D spatially selective NMR pulses by simulated annealing. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1987. Vol. 1. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1987, p. 479. 62. Bottomley P, Charles C, Roemer P, Flamig D, Engeseth H, Edelstein W, Mueller O, and Rezvani O. Human in vivo 31P 3DFT volume spectroscopic imaging revisited: new technical solutions and metabolite quantification. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1987. Works in Progress. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1987, p. 8. 63. Bottomley PA, Rogers HH. In situ nuclear magnetic resonance imaging of nodulated roots of Viga Unguiculata L. American Society of Plant Physiology Annual Meeting, Reno, NV July 1988. Plant Physiol. 1988; 86: 139.


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64. Bottomley PA. Clinical in vivo spectroscopy: techniques, applications, and findings. Program and Handbook, ANZAAS Centenary Congress, Sydney Australia, May 16-20, 1988, P 52. 65. Hardy CJ, Bottomley PA. Slice selection without gradient refocusing? A simulated annealing approach. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1988. Vol. 2. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1988, p. 657. 66. Weiss RG, Bottomley PA, Hardy CJ, Chacko VP, Glickson JD, Gerstenblith G. In vivo carbon-13 NMR spectroscopy of canine and human hearts. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1988. Vol. 2. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1988, p. 672. 67. Hardy CJ, Bottomley PA, Roemer PB, Mueller OM, Redington RW. In vivo localized 31P spectroscopy on a 4 Tesla whole-body magnet. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1988. Vol. 2. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1988, p. 703. 68. Bottomley PA, Hardy CJ. Precise metabolite assays in vivo? In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1988. Vol. 2. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1988, p. 824. 69. Bottomley PA, Hardy CJ. 31P spectroscopic imaging of the human heart. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1988. Vol. 2. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1988, p. 832. 70. Bottomley PA. NMR spectroscopy studies of normal and diseased human heart metabolism. In: Modern Cardiac Imaging Coarse book, Harvard Medical School Department of Continuing Education Beth Israel Hospital Department of Radiology, Boston, May 5-7 1989, p. 57-59. 71. Bottomley PA, Weiss RG, Hardy CJ, Schulman SP, Gerstenblith G. High energy phosphate metabolism in the heart monitored by 31P NMR spectroscopy during exercise in patients with coronary artery disease. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1989. Vol. 1. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1989, p. 35. 72. Bottomley PA, Hardy CJ. Imaging high energy phosphate metabolic flux with saturation-transfer spectroscopy: a 4T NMR "PET" machine? In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1989. Vol. 1. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1989, p. 253. 73. Bottomley PA, Hardy CJ, Cousins J, Armstrong M, Wagle W. Brain phosphate metabolite concentrations, not ratios reduced in AIDS dementia. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1989. Vol. 1. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1989, p. 369. 74. Hardy CJ, Weiss RG, Bottomley PA, Gerstenblith G, Chacko VP. Localized phosphorus-31 NMR spectroscopy in humans with dilated cardiomyopathy. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1989. Vol. 2. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1989, p 509. 75. Bottomley PA, Weiss RG, Hardy CJ, Chacko VP, Augustine S, Baumgartner WA. Abnormalities in cardiac high-energy phosphate metabolism in rejecting and normal heart-transplant patients by 31P NMR. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1989. Vol. 2. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1989, p. 510. 76. Bottomley PA, Roemer PB. Local RF power deposition in tissue in elevated in 1H NMR decoupling experiments employing surface coils. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1989. Vol. 2. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1989, p. 997.


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77. Weiss RG, Bottomley PA, Hardy CJ, Schulman SP, Gerstenblith. 31P NMR detected exercise changes in heart metabolism in patients with coronary artery disease. The 1989 American Heart Association Meeting, New Orleans Nov. 13-17, 1989. Circulation 1989; 80 (Suppl. II): II-588. 78. Bottomley PA, Hardy CJ, Roemer PB, Weiss RG, Gerstenblith G, Cousins JP. Application-driven spatial localization protocols for clinical spectroscopy in the heart and brain. Joint SMRM-SMRI Symposium on Spectroscopy, Washington, DC, Feb. 25, 1989. Magn Reson Imag 1990; 8(S1): 172. 79. Weiss RG, Bottomley PA, Hardy CJ, Gerstenblith G. Exercise-induced changes in cardiac high energy phosphates in patients with ischemic disease resolve after revascularization. The 1990 American Heart Association Meeting, Dallas, Nov. 12-15, 1990. Circulation 1990; 82 (SIII): III-684. 80. Bottomley PA, Weiss RG, Hardy GJ, Gerstenblith G. Assessment of myocardial ischemia in patients with coronary disease by 31P NMR stress-taking: response to therapy. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1990. Vol. 1. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1990, p. 244. 81. Hardy CJ, Bottomley PA, Cline HE. A generalized approach to two-dimensional selection excitation". In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1990. Vol. 1. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1990, p. 412. 82. Hardy CJ, Weiss RG, Bottomley PA, Gerstenblith G. Altered cardiac energy status in human cardiomyopathy: correlation with etiology and ejection fraction. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1990. Vol. 2. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1990, p. 931. 83. Bottomley PA. Clinical magnetic resonance spectroscopy of the heart. In: Society of Magnetic Resonance in Medicine Introduction to clinical spectroscopy, syllabus, 9th Annual Meeting, Aug 18-19, 1990. Berkeley CA: Society of Magnetic Resonance in Medicine, 1990, pp 53-59. 84. Bottomley PA. Localization strategies for in vivo human chemical shift spectroscopy. In: 29th Eastern Analytical Symposium official program, Nov 12-16, 1990, Somerset NJ. Montchanin DE: Eastern Analytical Symposium Inc, 1990 p.46. 85. Hardy CJ, Bottomley PA, Rohling KW, Roemer PB. Human cardiac 31P spectroscopy with NMR phased arrays. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1991. Vol. 1. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1991, 184. 86. Bottomley PA, Cousins JP, Alger J, Eames FA, Wagle WA, Lefkwicz DP, Thompson DA, Hardy CJ, Murphy D, Rosenberg J, Shapiro M, Rappoport SI, Horwitz B. Brain phosphate metabolite levels in Alzheimer's dementia: A multi-institutional study. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1991. Vol. 1. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1991, p 295. 87. Bottomley PA, Weiss RG, Hardy CJ, Baumgartner WA. Myocardial high energy phosphate metabolism and allograft rejection in chronic heart transplant patients. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1991. Vol. 2. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1991, p 575. 88. Bottomley PA, Weiss RG, Hardy CJ, Gerstenblith G. "31P NMR stress-testing in patients with coronary disease: Evidence for myocardial PCr/Pi changes". In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1991. Vol. 2. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1991, p. 577. 89. Bottomley PA, Hardy CJ, Weiss RG. "Saturation factors for high-energy phosphate ratios in human heart are homogeneous in normal and disease states. A practical solution for correcting partial


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saturation." In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1991. Vol. 2. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1991 p. 578. 90. Bottomley PA. Phosphorus NMR For studying energy metabolism in human heart: problems, solutions and findings. In: Book of Abstracts, Perspectives in magnetic resonances: frontiers in biochemistry and physiology, National Research Council, Canada, 75th Anniversary Symposium, Ottawa, Canada Oct. 7-8, 1991, p14. 91. Bottomley PA, Hardy CJ. Quantitative NMR spectroscopy of human heart. In: Presentations of the Scientific Conference on the Application of Magnetic Resonance to the Cardiovascular System, Dec 15-18, 1991, Atlanta GA. American Heart Association and the Society of Magnetic Resonance in Medicine, 1991. 92. Weiss RG, Bottomley PA, Hardy CJ, Gerstenblith G. Detecting ischemic heart disease with NMR by exercise-induced changes in myocardial metabolism. In: Presentations of the Scientific Conference on the Application of Magnetic Resonance to the Cardiovascular System, Dec 15-18, 1991, Atlanta GA. American Heart Association and the Society of Magnetic Resonance in Medicine, 1991. 93. Bottomley PA. Quantitative in vivo phosphorus NMR spectroscopy in the heart and brain: diagnostic tool or research probe? Jap J Magn Reson Med 1992; 12 (S1): 51-54. 94. Cousins JP, Bottomley PA, Pendrey DL, Hardy CJ, Factor S, McCaffrey RJ, Wagle WA. High energy phosphate concentrations in Parkinson's disease: comparison with Alzheimer's and AIDS dementia. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1992. Vol. 1. Berkeley, CA: Society of Magnetic Resonance in Medicine, 1992 p 753. 95. Bottomley PA, Dumoulin CL. Towards spatially localized double quantum spectroscopy measurements of lactate in humans. In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1992. Berkeley, CA: Society of Magnetic Resonance in Medicine 1992;1: 934. 96. Bottomley PA. Quantifying human cardiac and brain energy metabolism in normal and disease states with phosphorus NMR spectroscopy. In: British Radiofrequency Spectroscopy Group Meeting, NMR: New Applications to Materials and Medical Imaging, Nottingham, UK, 12-15 April, 1992. Nottingham: British Radiofrequency Spectroscopy Group, 1992. 97. Bottomley PA. Biomedical imaging: windows to the body across the spectrum, from DC to -rays. Workshop: Biomedical Imaging I-DC-10MHz. In: Science Innovation '92, New Techniques and Instruments in Biomedical Research, program book. Washington, American Association for the Advancement of Science 1992; 79. 98. Bottomley, PA. Workshop: Biomedical Imaging II-1-500MHz. In: Science Innovation '92, New Techniques and Instruments in Biomedical Research (abstract), program book. Washington, AAAS 1992; 82. 99. Bottomley, PA. Workshop: Biomedical Imaging III-0.1 THz and above. In: Science Innovation '92, New Techniques and Instruments in Biomedical Research. Program book. Washington, AAAS 1992; 110. 100. Hardy CJ, Bottomley PA, Roemer PB, Weiss RG, Darrow R. NMR M-mode imaging and 31P spectroscopy of the human heart. In: Proceedings of the Cardiovascular Science and Technology Conference, Bethesda MD, Dec 12-14, 1992. Arlington VA: Association for the Advancement of Medical Instrumentation 1992; 200. 101. Bottomley PA. Phosphorus NMR spectroscopy in human heart: current status of clinical studies. In: de Roos A, van der Wall EE, eds. 2nd Course on MR Angiography and Cardiovascular Imaging, syllabus. Leiden, The Netherlands: University of Leiden 1993; 1-6.


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102. Bottomley PA, Brady TJ. Workshop: Functional magnetic resonance imaging. In: Science Innovation 1993, Conference on New Research Techniques, Program and abstract book. Washington, American Association for the Advancement of Science 1993; 110. 103. Bottomley PA. Human cardiac spectroscopy: the status and the challenges. Proc SMRM 1993; 1: 216. 104. van Zijl PCM, Barker PB, Soher BJ, Gillen J, Bottomley PA, Duyn J, Moonen CTW, Weiss RG. Proton spectroscopic imaging of 13C-labelled compounds on a 1.5 Tesla standard clinical imager. Proc SMRM 1993; 1: 373. 105. Ouwerkerk R, Bottomley PA. Efficient new T1 measurement method employing low-angle adiabatic pulses. Proc SMRM 1993; 3: 1209. 106. Bottomley PA. Whither human cardiac spectroscopy? Abstracts of the First Nottingham Symposium on Magnetic Resonance in Medicine, Nottingham UK, 6-8 April 1994. Nottingham, University of Nottingham, 1994. 107. Bottomley PA, Ouwerkerk R. Choosing flip-angles when T1 is uncertain. Proc SMR 1994; 3: 1207. 108. Conway MA, Ouwerkerk R, Rajagopalan B, Radda GK, Bottomley PA. Low PCr/ATP ratio in eccentric hypertrophy in severe mitral regurgitation. Proc SMR 1994; 3: 1218. 109. Bottomley PA. Human cardiac spectroscopy. Jap J Magn Reson Med 1994; 14(S): 55-56. 110. Cousins JP, Tomalski W, Westervelt H, Bottomley PA, Hardy CJ, Remick S, Szebenyi S, Haase R, Lagrange A, McCaffrey RJ, Wagle WA. Temporal changes in phosphocreatine in symptomatic HIV patients observed by 31P NMR spectroscopy. Proc SMR 1995; 1: 53. 111. Bottomley PA, Weiss RG. The creatine pool in human heart by proton NMR spectroscopy. Proc SMR 1995; 1: 90. 112. Bottomley PA, Atalar E, Weiss RG. Human cardiac high-energy phosphate metabolite concentrations by 1D CSI. Proc SMR 1995; 1: 263. 113. Atalar E, Bottomley PA, Zerhouni EA. A flexible catheter coil for imaging and spectroscopy of atherosclerotic plaques. Proc SMR 1995; 2: 988. 114. Atalar EA, Bottomley PA, Zerhouni EA. Microscopic MR imaging and spectroscopy of arterial wall with an intravascular probe. 81st Annual Meeting of the Radiological Society of North America, Chicago Nov 26-Dec 1, 1995. Radiology 1995; 197(P): 248. 115. Bottomley PA, Luogo-Olivieri CH, Giaquinto R. What is the optimum phased-array coil design for cardiac magnetic resonance? Proc ISMRM 1996: 1: 248. 116. Bottomley PA, Sean YH Lee, Weiss RG. Proton MR spectroscopy of creatine in myocardial infarction. Proc ISMRM 1996; 1: 426. 117. Conway MA, Ouwerkerk R, Bottomley P, Radda GK, Rajagopalan B. Mitral regurgitation: evidence for a relationship between PCr/ATP and myocardial contractility normalized for wall-thickness. Proc ISMRM 1996; 1: 429. 118. Bottomley PA, Weiss RG. Reductions in creatine kinase metabolite concentrations in infarcted myocardium by noninvasive MRS. Proc ISMRM 1997; 1: 480.


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119. Bottomley PA. The rise of human in vivo spectroscopy. Proceedings, Annual Meeting of the Korean Society for Magnetic Resonance in Medicine (KSMRM). Seoul, Korea; KSMRM 1997; 32-34. 120. Bottomley PA. Cardiac MR: the new frontier. Proceedings, Annual Meeting of the Korean Society for Magnetic Resonance in Medicine (KSMRM). Seoul, Korea; KSMRM 1997; 61-62. 121. Lee R, Bottomley PA. A 4D chirp and Fourier velocity encoding method for MRI flow velocity measurement. 83rd Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA), Chicago Nov 30-Dec 5, 1997. Radiology (supplement) 1997; 205 (P); 349. 122. Bottomley PA, Lee RF, Constantinides CD, Weiss RG. Sodium MRI of acute myocardial infarction at 1.5 Tesla. Proc ISMRM 1998; 2: 892. 123. Bottomley PA, Lee RF, Constantinides CD, Weiss RG. Direct 31P MRI of high-energy phosphate metabolites at 1.5 Tesla. Proc ISMRM 1998; 3: 1869. 124. Bottomley PA, Lee RF, Constantinides CD, Weiss RG. Sodium magnetic resonance imaging of acute myocardial infarction at 1.5 Tesla. SCMR, The First Annual Meeting of the Society of Cardiovascular Magnetic Resonance 1998. SCMR, Mt Royal New Jersey 1998: 97. 125. Bottomley PA, Weiss RG. Human cardiac spectroscopy. Magnetic resonance in Cardiovascular Research, 4th Scientific Meeting and Teaching Course, Sept 24-26, 1998. Magn Reon Mater Phy 1998; 6: 157-160. 126. Constantinides C, Boada F, Gillen J, Kraitchman D, Solaiyappan M, Bottomley PA. Fast high resolution 23Na MRI with twisted projections: imaging myocardial infarction in 3D. Proc Intl Soc Mag Reson Med 1999; 1: 221. 127. Lee RF, Giaquinto R, Constantinides C, Souza S, Weiss RG, Bottomley PA. Phased-array metabolic imaging of nuclei other-than-hydrogen. Proc Intl Soc Mag Reson Med 1999; 1: 278. 128. Constantinides C, Gillen J, Boada F, Bottomley PA. 23Na Imaging and quantification of skeletal muscle at 1.5 T. Proc Intl Soc Mag Reson Med 1999; 1: 311. 129. Lee RF, Bottomley PA. An analytical transform for SMASH imaging in MRI. Proc Intl Soc Mag Reson Med 1999: 1: 667. 130. Bottomley PA, Lee RF, Weiss RG. Constructive averaging increases SNR of creatine MRS in the presence of motion. Proc ISMRM 1999:1: 687. 131. Ouwerkerk R, Lee RF, Bottomley PA. Dynamic changes in sodium levels in human exercising muscle measured with 23Na MRI. Proc Intl Soc Mag Reson Med 1999; 3:1530. 132. Constantinides CD, Bottomley PA, Lee RF, Weiss RG. Restoration of metabolic images with a priori anatomic information. Proc Intl Soc Mag Reson Med 1999; 3: 2116. 133. Bottomley PA, Weiss RG, Lee RF, Ouwerkerk R. Quantification and imaging of human myocardial phosphorus, proton and sodium metabolites. The Third Annual Meeting of the Society of Cardiovascular Magnetic Resonance, Atlanta GA, Jan 21-23 2000, Conference agenda. SCMR, Mt Royal New Jersey 2000; 18. 134. Weiss RG, Chacko VP, Bottomley PA. Myocardial bioenergetics from mice to men: A few lessons from 31P NMR cardiac spectroscopy about the metabolic consequences of transgenic manipulations and human disease. The Third Annual Meeting of the Society of Cardiovascular Magnetic Resonance, Atlanta GA, Jan 21-23 2000, Conference agenda. SCMR, Mt Royal New Jersey 2000; 40.


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135. Bottomley PA, Atalar E, Halperin H, Lardo A, Foo T, Yang X. MRI at the leading edge: high speed and high resolution. Society of Cardiovascular & Interventional Radiology, 25th Annual Meeting, San Diego Mar 27, 2000. J Vasc Interv Radiol 2000; 11 (suppl); 348. 136. Constantinides CD, Kraitchman D, O’Brien K, Boada F, Gillen J, Bottomley PA. Noninvasive quantification of total sodium concentrations in myocardial infarction using 23Na MRI. Proc Intl Soc Mag Reson Med 2000; 1: 130. 137. Ouwerkerk R, Lee R, Weiss RG, Bottomley P. A new FAST method for in vivo measurement of chemical exchange rates. Proc Intl Soc Mag Reson Med 2000; 1: 421. 138. Lee RF, Westgate CR, Weiss RG, Bottomley PA. Planar strip antenna for parallel spatial encoded MRI. Proc ISMRM 2000; 1; 558. 139. Constantinides CD, Herzka D, Bolar D, Boada F, Kraitchman D, Bottomley PA, Rogers J. Superparamagnetic iron oxide MION: a contrast agent for 23Na cardiac MRI in myocardial infarction. Proc Intl Soc Mag Reson Med 2000; 3: 2043. 140. Bottomley PA, Lee RF, Constantinides CD, Ouwerkerk R, Weiss RG. Quantification and imaging of myocardial sodium and creatine kinase metabolites. 5th International Symposium on magnetic resonance in cardiovascular research Marseille, France, September 8-9, 2000. Magn Reon Mater Phy 2000; 11: 39-41. 141 Bottomley PA, E, Lee RF, Shunk KA, Lardo A. Cardiovascular MRI probes for the outside in and for the inside out. 5th International Symposium on magnetic resonance in cardiovascular research Marseille, France, September 8-9, 2000. Magn Reon Mater Phy 2000; 11: 49-51. 142. Pisacane VL, Bottomley PA, Chacko VP, Feldmesser HS,Wetsel GC. Space qualifiable magnetic resonance imaging system (poster). NASA Bioastronautics meeting, Houston TX, 18-19 Jan 2001. 143. Solaiyappan M, Beache GM, Gupta SN, Bottomley PA. A graphical approach for the analysis of myocardial BOLD effect. Proc ISMRM 2001; 1: 599. 144. Ouwerkerk R, Pomper M, Bottomley PA. Quantitative 3D sodium MRI of Brain tumors. Radiological Society of North America (RSNA) annual meeting, Nov 25-30 2001. Radiology 2001; 221(P): 294. 145. Bottomley PA, Ouwerkerk R, Weiss RG, Lee R. Creatine kinase reaction kinetics in humans: the final frontier for quantitative 31P MRS. Joint Meeting, Magnetic Resonance in Cardiovascular Research 6th International sypmosium and British Society for Cardiovascular research in Oxford, Mar 22-23, 2002, Oxford University, UK. Abstract Book, p33. 146. Lee RF, Edelstein W, Bottomley P, Sodickson D, Kenwood G, Hardy C. Lumped-Element Planar Strip Array (LPSA) for MRI at 1.5T. Proc Intl Soc Mag Reson Med 2002; 10: 321. 147.Kumar A, Bottomley P. Tunable Planar Strip Array Antenna. Proc Intl Soc Mag Reson Med 2002; 10: 322. 148. Weiss RG, Ouwerkerk R, Gerstenblith G, Bottomley PA. Quantification of cardiac creatine kinase flux in the human heart art rest and during stress. Proc Intl Soc Mag Reson Med 2002; 10: 682. 149. Viohl I, Lardo A, S Tully, Karmakar P, Bottomley PA. The Efficacy of Decoupling Methods to Minimize RF Heating Due to Internal Conducting Devices Used in MRI. Proc Intl Soc Mag Reson Med 2002; 10: 702.


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150. Ouwerkerk R, Jacobs MA, Bottomley PA, Fajardo LL. A Method for Quantifying Tissue Sodium in Breast Tumors with Short Echo Time 23 Na MRI and Co-registered Proton Images. Proc Intl Soc Mag Reson Med 2002; 10: 2061. 151. Ronald Ouwerkerk R, Karen B Bleich KB, Pomper MG, Bottomley PA. Absolute Quantification of Tissue Sodium in Gliomas. Proc Intl Soc Mag Reson Med 2002; 10: 2090. 152. Hardy CJ, Darrow RD, Saranathan M, Giaquinto R, Rohling K, Dumoulin CL, Zhu Y, Bottomley PA. Real-Time Large-FOV MRI with a Massively Parallel 32-Channel MRI System and Detector Array. Proc Intl Soc Mag Reson Med 2003: 11: 471. 153. Jacobs MA, Ouwerkerk R, Bottomley PA, Barker PB, Wolff A, Davidson N, Bhujwalla Z, Bluemke DA. Multiparametric proton, sodium, and metabolic spectroscopic magnetic resonance imaging of human breast cancer. Proc Intl Soc Mag Reson Med 2003; 11: 532 154. Ouwerkerk R, Bottomley PA. Minimal errors in measuring creatine kinase flux when exchange between ATP. Proc Intl Soc Mag Reson Med 2003; 11: 849. 155. Ouwerkerk R, Weiss RG, Bottomley PA. Quantifying Sodium Content in Human Heart with Short-echo, Adiabatic, Twisted Projection 23Na MRI. Proc Intl Soc Mag Reson Med 11; 2003: 869. 156. Lee RF, Hardy CJ, Bottomley PA. Radial SMASH for Parallel Back Projection Reconstruction MRI. Proc Intl Soc Mag Reson Med 2003; 11: 2350. 157. von Morze C, Bottomley PA, Schenck JF, Hardy CJ. A Planar Gradient Set for Rapid MR Imaging. Proc Intl Soc Mag Reson Med 2003; 11: 2420. 158. Bottomley PA. Of MRI, the exile of nuclei, and thirty year wars. 2004 ENC Conference Proceedings. 159. Jacobs MA, Ouwerkerk R, Wolff AC, Stearns V, Bottomley PA, Bluemke DA, Bhujwalla Z. Monitoring Primary Systemic Therapy in Locally Advanced Breast Cancer using Proton and Sodium Magnetic Resonance Imaging. Proc Intl Soc Mag Reson Med 2004; 12: 246. 160. Bottomley PA, Gerstenblith G, Weiss RG. The ATP Flux Generated by Creatine Kinase in the Human Heart at Rest and during Stress. Proc Intl Soc Mag Reson Med 2004; 12: 2359. 161. Bottomley PA, Gerstenblith G, Weiss RG. Impaired Creatine Kinase ATP Supply in the Failing Human Heart. Proc Intl Soc Mag Reson Med 2004; 12: 2360. 162. Najjar SS, Bottomley PA, Schulman SP, Waldron MM, Gerstenblith G, Weiss RG. Does Right-Shifting Hemoglobin-Oxygen Dissociation Attenuate Exercise-Induced Ischemia in Patients with Coronary Artery Disease? Circulation 2004; 110: III-323. 163. Smith C, Bottomley PA, Gerstenblith G, Schulman SP, Weiss RG. Reduced ATP synthesis through creatine kinase in failing and non-failing hypertrophied human myocardium. Circulation 2004; 110: III-610. 164. Jacobs MA, Ouwerkerk R, Bottomley PA, Kim HS. Multiparametric Proton and Sodium MRI of Uterine Fibroids Pre- and Post-treatment. Proc Intl Soc Mag Reson Med 2005; 13: 154. 165. Aksel B, Hardy CJ, von Morze C, Bottomley PA. Design and Manufacture of a Planar Gradient Set for Rapid Body MRI with Intense Gradients. Proc Intl Soc Mag Reson Med 2005; 13: 857. 166. Bottomley PA, Smith C, Gerstenblith G, Weiss RG. ATP flux through Creatine Kinase in Hypertrophic and Dilated Hearts: Altered Kinetics in Human Heart Failure. Proc Intl Soc Mag Reson Med 2005; 13: 1693.


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167. Bottomley PA, Gerstenblith G, Schulman S, Steinberg A, Wu KC, Weiss RG. Creatine kinase flux and metabolite concentrations in the dysfunctional human heart following infarction. Proc Intl Soc Mag Reson Med 2005; 13: 1694. 168. Karmarkar PV, Baker KB, Lowe MJ, Phillips M, Steiner C, Viohl I, Nyenhuis JA, Bottomley PA, Rezai AR. An Active Microelectrode System for Experimental MRI-Guided Intracranial Intervention. Proc Intl Soc Mag Reson Med 2005; 13: 2162. 169. Ouwerkerk R, Bottomley PA. Improved Twisted Projection Imaging with Low Gradient Slew-Rates. Proc Intl Soc Mag Reson Med 2005; 13: 2373. 170. Ouwerkerk R, Wu KC, Solaiyappan M, Bottomley PA, Weiss RG. Quantitative 23Na MRI in Chronic Human Myocardial Infarction. Proc Intl Soc Mag Reson Med 2005; 13: 2791. 171. El-Sharkawy AM, Sotiriadis P, Bottomley P, Atalar E. Accurate Absolute Thermal Monitoring with RF Radiometry. Proc Intl Soc Mag Reson Med 2006; 14: 697. 172. Aksel B, Collick BD, Luca Marinelli L, Barber WD, Bottomley PA, Hardy CJ. Local Planar Gradients with Order-Of-Magnitude Strength and Speed Advantage. Proc Intl Soc Mag Reson Med 2006; 14: 780. 173. Gabr RES, Ronald Ouwerkerk R, Paul A. Bottomley PA. 2529. CFIT: A Novel Circle-Fitting Approach to Spectral Analysis. Proc Intl Soc Mag Reson Med 2006; 14: 2529. 174. Gabr RES, Schär M, Sathyanarayana S, Weiss RG, Bottomley PA. Predicting SNR Gains from Constructive Averaging of Proton Spectra: Theory and Practice. Proc Intl Soc Mag Reson Med 2006; 14: 2540. 175. Kumar A, Bottomley PA. Optimizing the SNR Performance of the Tunable Strip Detector. Proc Intl Soc Mag Reson Med 2006; 14: 2620. 176. Gabr RE, Aksit P, Bottomley PA, Youssef ABM, Kadah YM. Iterative Deconvolution-Interpolation Gridding. Proc Intl Soc Mag Reson Med 2006; 14: 2952. 177. Hardy CJ, Darrow RD, Marinelli L, Aksit P, Foo TKF, Weiss RG, Bottomley PA. 32-Channel Real-Time MRI at ~50 Frames Per Sec for Irregular Heart Motion. Proc Intl Soc Mag Reson Med 2006; 14: 3599. 178. Bottomley PA, Gabr RE, Weiss RG. MRS of the heart. ISMRM Workshop on Data Processing for MR Spectroscopy and Imaging Warrenton VA, 11-13 Nov 2006, Syllabus. International Society of Magnetic Resonance in Medicine 2006, Berkeley CA; CDROM; 03, pp 1-3. 179. Gabr RE, Bottomley PA. Improving the Circle Fitting (CFIT) Performance for MRS Data Quantification. ISMRM Workshop on Data Processing for MR Spectroscopy and Imaging, Warrenton VA 11-13 Nov 2006, Syllabus. International Society of Magnetic Resonance in Medicine 2006, Berkeley CA; CDROM; P06. 180. Sathyanarayana S, Schar M, Bottomley PA. An MRI endoscope? Proc Intl Soc Mag Reson Med 2007; 15: 492. 181. Kumar A, Bottomley PA. Optimized Quadrature Surface Coils incorporating Circular, Figure-8 loops, and Strips. Proc Intl Soc Mag Reson Med 2007; 15: 1049. 182. El-Sharkawy AM, Abd-Elmoniem KZ, Prince JL, Bottomley PA. Simultaneous Temperature and Motion Tracking Using HARP MRI [T-HARP]. Proc Intl Soc Mag Reson Med 2007; 15: 1129.


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183. Qian D, El-Sharkawy AM, Bottomley PA. The 3T Loopless Antenna: SNR Triples Compared to 1.5T, Heating Suppressed. Proc Intl Soc Mag Reson Med 2007; 15: 3383. 184. El-Sharkawy AEM, Schär M, Ouwerkerk R, Weiss RG, Bottomley PA. 31P cardiac spectroscopy at 3T: T1 quantification. Abstracts of the 11th Annual SCMR Scientific Sessions, Jan 31-Feb3 2008. J Cardiovasc M R 2008, 10(Suppl 1):A48 doi:10.1186/1532-429X-10-S1-A48. 185. El-Sharkawy AM, Schar M, Ouwerkerk R, Weiss RG, Bottomley PA. Quantitative Cardiac 31P Spectroscopy at 3T: Practical Limitations and Solutions. Proc Intl Soc Mag Reson Med 2008; 16: 192. 186. Sathyanarayana S, Schar M, Bottomley PA. MRI endoscopy at 3T. Proc Intl Soc Mag Reson Med 2008; 16: 279. NIHMSID # 106475. 187. Gabr RE, Schar M, Edelstein AD, Bottomley PA, Edelstein WA. MRI Dynamic Range: Theory and Measurement. Proc Intl Soc Mag Reson Med 2008; 16: 1129. NIHMSID # 602708. 188. Sathyanarayana S, Schär M, Solaiyappan M, Bottomley PA. Intrinsically localized internal imaging probes: The MRI endoscope. In: 7th Interventional MRI Symposium, Sept 12-13, 2008 Book of Abstracts. Lewin JS, Kahn T, Jolesz FA, eds. Baltimore MD 2008; V2. 189. Qian D, El-Sharkawy AM, Bottomley PA. Proc. The performance of intravascular MRI with loopless antennae at 3T. In: 7th Interventional MRI Symposium, Sept 12-13, 2008 Book of Abstracts. Lewin JS, Kahn T, Jolesz FA, eds. Baltimore MD 2008; P8. 190. Sathyanarayana S, Schär M, Solaiyappan M, Bottomley PA. Real-time intravascular MRI endoscopy at 3T. Proc Intl Soc Mag Reson Med 2009; 17: 65. NIHMSID # 190762. 191. Schär M, El-Sharkawy AM, Bottomley PA, and Weiss RG. 31P TRIple TR Saturation Transfer (TRIST) in the Human Heart at 3T. Proc Intl Soc Mag Reson Med 2009; 17: 709. 192. Qian D, EL-Sharkawy AM, Bottomley PA. Tapering improves the forward-looking properties of the interventional loopless antennae. Proc Intl Soc Mag Reson Med 2009; 17: 4427. PMC#2855976. 193. Kumar A, Edelstein WA, Bottomley PA. Noise Figure Limits for Circular Loop MR Coils. Proc Intl Soc Mag Reson Med 2009; 17: 4728. 194. Bottomley PA, Edelstein WA, Kumar A, Allen JM, Karmarkar P. Resistance and Inductance Based MRI-safe Implantable Lead Strategies. Proc Intl Soc Mag Reson Med 2009; 17: 4805. 193 Schär M, El-Sharkawy A M, Bottomley PA, Weiss RG. Reduced myocardial creatine kinase reaction rates in human heart failure: first measurements at 3T. Proc Intl Soc Mag Reson Med 2010; 18: 166. 194. Bottomley PA, Edelstein WA, Kumar A, Allen J, Karmarkar P. Towards MRI-safe implanted leads: a comparative evaluation of four designs. Proc Intl Soc Mag Reson Med 2010; 18: 776. 195. El-Sharkawy AM, Qian D, Bottomley PA, Edelstein WA. Accurate Measurement of RF Power Deposition During 3T MRI. Proc Intl Soc Mag Reson Med 2010; 18: 3853. NIHMSID # 292808 196. Kumar A, Karmarkar P, Edelstein WA, Bottomley PA. Insulation, lead-length, and sample-size affect the MRI-safety of implanted leads. Proc Intl Soc Mag Reson Med 2010; 18: 3893. 197. Bottomley PA, Sathyanarayana, Schar M, Kraitchman DL. Real-time intravascular-coil based MRI at 3T. In: 8th Interventional MRI Symposium Book of Abstracts, Kahn T, Jolesz FA, Lewin JS, eds. Leipzig Germany 2010; pp 147-8. ISBN 978-3-00-032186-3 (http://www-e.uni-magdeburg.de/jkrug/docs/IMRI2010_Abstract_Book.pdf).

http://www-e.uni-magdeburg.de/jkrug/docs/IMRI2010_Abstract_Book.pdf



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198. Bottomley PA, Kumar A, Edelstein WA, Allen JM, Karmarkar PV. Designing MRI-safe implantable leads. In: 8th Interventional MRI Symposium Book of Abstracts, Kahn T, Jolesz FA, Lewin JS, eds. Leipzig Germany 2010; pp 324-5. ISBN 978-3-00-032186-3 (http://www-e.uni-magdeburg.de/jkrug/docs/IMRI2010_Abstract_Book.pdf). 199. El-Sharkawy AM, Qian D, Bottomley PA, Edelstein WA. A Multi-Channel, High Dynamic Range, Real Time RF Power Deposition Monitor. Proc Intl Soc Mag Reson Med 2011; 19: 496. NIHMSID # 292801. 200. Gabr RE, El-Sharkawy AM, Schär M, Weiss RG, Bottomley PA. Measuring energy diffusion: phosphocreatine in human skeletal muscle. Proc Intl Soc Mag Reson Med 2011; 19: 1140. NIHMS292812. 201. Qian D, Bottomley PA. Identification and quantification of atherosclerosis in arterial vessels using an interventional 3T loopless detector. Proc Intl Soc Mag Reson Med 2011; 19: 1250. NIHMS292813 202. Zhang Y, Gabr RE, Schär M, Weiss RG, Bottomley PA. Encoding of pre-selected compartments produces large SNR and speed advantages for 31P MRS. Proc Intl Soc Mag Reson Med 2011; 19: 1438. NIHMS292804. PMC3187912. 203. Wang G, El-Sharkawy AM, Edelstein WA, Schär M, Bottomley PA. Measuring and Imaging T2 without Echoes? Proc Intl Soc Mag Reson Med 2011; 19: 2753. NIHMSID # 292807. 204. Knoepp L, Bottomley PA, Qian D, Shellock FG, Kwong YT, Wright EJ, Chen CCG. Sacral Neuromodulation and MRI Safety: A hot topic? An investigation of MRI issues for the Interstim. 32nd American Urogynecologic Society 32nd Annual Meeting, Providence RI Sept 14-17 2011. P69. Female Pelvic Med Reconstr Surg 2011; 17(5) Suppl 1: S83-S84. 205. Zhang Y, Gabr RE, Schär M, Zhu H, Barker P, Weiss RG, Bottomley PA. Dramatic speedup in 1D-, 2D- and 3D-MRS scan times with linear algebraic modeling (SLAM). Proc Intl Soc Mag Reson Med 2012; 20: 709. NIHMSID # 521422. 206. Wang G, El-Sharkawy AM, Edelstein WA, Schär M, Bottomley PA. Measuring T1 and T2 and proton

density in 3 acquisitions: the tri- method. Proc Intl Soc Mag Reson Med 2012; 20: 1736. NIHMSID #

521431. 207. Zhang Y, Gabr RE, Schär M, Zhu H, Barker P, Weiss RG, Bottomley PA. Dramatic speedup in 1D-, 2D- and 3D-MRS scan times with linear algebraic modeling (SLAM). Proc Intl Soc Mag Reson Med 2012; 20: 709. NIHMSID # 521422. 208. Kraitchman DL, Qian D, Bottomley PA, Weiss CR. Unexpected Heating of MR-compatible Cryoablation Probes Using a Conventional 1.5T MR Scanner. Proc Intl Soc Mag Reson Med 2012; 20: 2927. NIHMSID: NIHMS521434. 209. Erturk MA, El-Sharkawy AM, Bottomley PA. The Interventional Loopless Antenna at 7 Tesla. Proc Intl Soc Mag Reson Med 2012; 20: 2944. NIHMSID # 521437. 210. El-Sharkawy AM, Gabr RE, Schär M, Weiss RG, Bottomley PA. Human Cardiac 31P Metabolite Concentrations at 3T. Proc Intl Soc Mag Reson Med 2012; 20: 4405. 211. Erturk MA, El-Sharkawy AEM, Moore J, Bottomley PA. Interventional MRI endoscopy using a transmit/receive loopless antenna at 7T. In: 9th International Interventional MRI Symposium Book of Abstracts. Jolesz FA, Lewin JS, Kahn T, eds. Boston MA 2012; p 46




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212. Hedge SS, Bottomley PA. Motion correction in intravascular MRI using projection reconstruction. In: 9th International Interventional MRI Symposium Book of Abstracts, Jolesz FA, Lewin JS, Kahn T, eds. Boston MD 2012; p 89. 213. Panjrath GS, Schär M, El-Sharkawy AEM, Gabr RE, Schulman SP, Gerstenblith G, Bottomley PA, Weiss RG. Skeletal muscle ATP kinetics during exercise in patients with systolic heart failure. J Cardiovasc Magn Reson. 2013; 15(Suppl 1): O29. doi: 10.1186/1532-429X-15-S1-O29. PMC3559453. 214. Hegde SS, Zhang Y, Bottomley PA. Accelerated, Motion-Corrected High-Resolution Intravascular MRI at 3T. Proc Intl Soc Mag Reson Med 2013; 21: 473. NIHMSID # 516278. 215. Zhang Y, Gabr RE, Zhou J, Weiss RG, Bottomley PA. Spectroscopy with Linear Algebraic Modeling (SLAM): Speed and Quantification in Brain Tumor Studies. Proc Intl Soc Mag Reson Med 2013; 21: 530. NIHMSID # 521443. 216. Gabr RE, El-Sharkawy AEM, Schär M, Weiss RG, Bottomley PA. Noninvasive Assessment of Cardiac Work and CK Energy Supply in Healthy and Failing Human Hearts. Proc Intl Soc Mag Reson Med 2013; 21: 579. 217. Hegde SS, Weiss CR, Erturk MA, Bottomley PA. 3T Intravascular MRI, IVUS and OCT: A Study in Contrast. Proc Intl Soc Mag Reson Med 2013; 21: 1833. NIHMSID # 516283. 218. Qian D, El-Sharkawy AEM, Bottomley PA, Edelstein WA. A Whole-Body RF Dosimeter for Independent SAR Measurement in MR Scanners. Proc Intl Soc Mag Reson Med 2013; 21: 2823. NIHMSID # 521450; PMC4211258. 219. Panjrath GS, Bottomley P, Lai S, Hirsch GA, Wu K, Najjar SS, Gerstenblith G, Weiss RG. Impaired energtics and heart failure: rates of adenosine triphosphate transfer through creatine kinase predict clinical heart failure events and death. JACC 2013; 61(10 suppl): E2115. https://doi.org/10.1016/S0735-1097(13)62115-4. 220. Erturk MA, El-Sharkawy AM, Bottomley PA. Monitoring local heating around an interventional MRI probe with RF radiometry. Proc Intl Soc Mag Reson Med. 2014; 22: 2349. 221. Wang G, Erturk MA, Hegde SS, Bottomley PA. High-resolution multi-parametric characterization of atherosclerotic lesions with 3T intravascular MRI. Proc Intl Soc Mag Reson Med. 2014; 22: 2534. 222. Zhang Y, Zhou J, Bottomley P. Partial volume correction of 1H brain CSI by grid shifting (PANGS). Proc Intl Soc Mag Reson Med. 2014; 22: 2877. 223. Wang G, El-Sharkawy AM, Bottomley PA. Imaging T1, T2 and proton density with minimum possible acquisitions. Proc Intl Soc Mag Reson Med. 2014; 22: 3203. 224. Hegde SS, Zhang Y, Bottomley PA. In vivo accelerated, motion-corrected free-breathing 3T intravascular MRI. Proc Intl Soc Mag Reson Med. 2014; 22: 3703. 225. Bottomley PA, Zhang Y, Wang G, Erturk MA, Hegde SS. MRI endoscopy: a path to high resolution parametric imaging and intervention. In: Book of Abstracts. 10th Interventional MRI Symposium-iMRI 2014, Leipzig Oct 10-11 2014. Kahn T, Jolesz FA, Lewin JS, eds. Leipzig Germany 2014 (ISBN 978-3-00-046995-4): p39. 226. Erturk MA, Hegde SS, Bottomley PA. A combined high-resolution internal imaging and RF ablation probe at 3T. In: Book of Abstracts. 10th Interventional MRI Symposium-iMRI 2014, Leipzig Oct 10-11 2014. Kahn T, Jolesz FA, Lewin JS, eds. Leipzig Germany 2014 (ISBN 978-3-00-046995-4): P136.

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227. Erturk MA, El-Sharkawy AM, Bottomley PA. RF safety in MRI: gauging body-average SAR and local heating of interventional coils. In: Book of Abstracts. 10th Interventional MRI Symposium-iMRI 2014, Leipzig Oct 10-11 2014. Kahn T, Jolesz FA, Lewin JS, eds. Leipzig Germany 2014 (ISBN 978-3-00-046995-4): p 151. 228. Zhang Y, Lee D-H, Zhang K, Mangraviti A, Yang C, Heo H-Y, Tyler B, Partanen A, Farahani K, Bottomley P, van Zijl P, Zhou J. Multi-Parametric MRI Assessment of Tumor Response to High-Intensity Focused Ultrasound in a Rat Glioma Model. Proc Intl Soc Mag Reson Med. 2015; 23: 36. NIHMSID 780321. 229. Zhang Y, Heo H-Y, Lee D-H, Jiang S, Bottomley P, Zhou J. Highly-Accelerated Chemical Exchange Saturation Transfer (CEST) Measurements with Linear Algebraic Modeling (SLAM). Proc Intl Soc Mag Reson Med. 2015; 23: 779. (Magna cum laude awardee) NIHMSID 780331. 230. Ertürk MA, Hegde SS, Bottomley PA. A combined interventional high-resolution targeted ablation, thermometry and imaging probe. Proc Intl Soc Mag Reson Med. 2015; 23: 1645. (Magna cum laude awardee). NIHMSID780299 231. Wang G, Erturk MA, Hegde SS, Bottomley PA. Automated classification of vessel disease based on high-resolution intravascular multi-parametric MRI. Proc Intl Soc Mag Reson Med. 2015; 23: 1659. NIHMSID 780306. 232. Wang G, Zhang Y, Hegde SS, Bottomley PA. Highly Accelerated, Intravascular T1, T2, and Proton Density Mapping with Linear Algebraic Modeling and Sensitivity Profile Correction at 3T. Proc Intl Soc Mag Reson Med. 2016; 24: 2829. http://indexsmart.mirasmart.com/ISMRM2016/PDFfiles/2829.html. NIHMSID 865664. 233. Zhang Y, Heo H-Y, Lee D-H, Jiang S, Zhao X, Bottomley P, Zhou J. Highly-accelerated CEST Measurements in Three Dimensions with Linear Algebraic Modeling. Proc Intl Soc Mag Reson Med. 2016; 24: 1524. http://indexsmart.mirasmart.com/ISMRM2016/PDFfiles/1524.html. NIHMSID 865665. 234. Zhang Y, Heo H-Y, Lee D-H, Bottomley P, Zhou J. Fast Chemical Exchange Saturation Transfer (CEST) Imaging with Variably-accelerated Sensitivity Encoding (vSENSE). Proc Intl Soc Mag Reson Med. 2016; 24: 1522. http://indexsmart.mirasmart.com/ISMRM2016/PDFfiles/1522.html. NIHMSID 865667. 235. Bottomley PA, Zhang Y. SLAM & Co. Syllabus, ISMRM Workshop on MR Spectroscopy: From Current Best Practice to Latest Frontiers Lake Constance, Germany, 14-17 Aug 2016. 236. Liu X, Ellens N, Burdette C, Karmarkar P, Bottomley P. Multifunctional Intravascular MRI-Ultrasound Ablation/Imaging/Thermometry System. 11th Interventional MRI Symposium, Baltimore MD Oct 7-8 2016, P34. 237. Bottomley PA. Magnetic Resonance Medical Imaging (MRI)-from the inside. Bulletin of the American Physical Society. APS March Meeting 2017. Abstract L29.00003. http://meetings.aps.org/Meeting/MAR17/Session/L29?showAbstract; https://absuploads.aps.org/presentation.cfm?pid=13322 238. Liu X, Ellens N, Williams E, Burdette CE, Karmarkar P, Bottomley P. Combined Intravascular MRI Endoscope and Intravascular Ultrasound (IVUS) Transducer for High-Resolution Image-Guided Ablation. Proc Intl Soc Mag Reson Med. 2017; 25: 1178. (http://indexsmart.mirasmart.com/ISMRM2017/PDFfiles/1178.html). NIHMSID 877785. 239. Zhang Y, Heo HY, Jiang S, Bottomley PA, Zhou J. Fast, Reliable 3D Amide Proton Transfer Imaging of Brain Tumors at 3T with Variably-accelerated Sensitivity Encoding (vSENSE). Proc Intl Soc Mag Reson Med. 2017; 25: 1971. (http://indexsmart.mirasmart.com/ISMRM2017/PDFfiles/1971.html). NIHMSID 877773.

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240. Zhang Y, Liu X, Zhou J, Bottomley PA. Ultrafast compartmental relaxation time mapping with linear algebraic modeling. Proc Intl Soc Mag Reson Med. 2017; 25: 0071. (http://indexsmart.mirasmart.com/ISMRM2017/PDFfiles/0071.html). NIHMSID 877792. 241. Gabr RE, El-Sharkawy AEM, Schär M, Gerstenblith G, Weiss RG, Bottomley PA. Creatine kinase energy supply correlates with mechanical work and efficiency in healthy and failing human heart: a combined noninvasive MRI/MRS study. Proc Intl Soc Mag Reson Med. 2018; 26: 1087. (http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/1087.html). 242. Liu X, Karmarkar P, Voit D, Frahm J, Bottomley P. Real-time MRI endoscopy at up to 10 frames/sec. Proc Intl Soc Mag Reson Med. 2018; 26: 0603. (Magna cum laude awardee. http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/0603.html) 243. Liu X, Ellens N, Williams E, Burdette C, Karmarkar P, Bottomley PA. Intra-vascular, MRI-Guided, perivascular ultrasound ablation with thermometric monitoring of therapy delivery. Proc Intl Soc Mag Reson Med. 2018; 26: 1194. (http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/1194.html). 244. Solaiyappan M, Weiss RG, Bottomley PA. Neural-network discrimination of cardiac disease from 31P MRS measures of myocardial creatine kinase energy metabolism. Proc Intl Soc Mag Reson Med. 2018; 26: 164. (http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/0164.html). 245. Bottomley P, Liu X, Karmarkar P, Voit D, Frahm J, Kraitchman D. Real-time MRI Endoscopy. Proceedings, 12th Interventional MRI Symposium, Marriott Longwarf, Boston USA, Oct 5-6 2018: 27. https://cdn.website-editor.net/ed4a3740370b414595b38f3fc1951e45/files/uploaded/TOC_IMRI2018.pdf 246. Liu X, Ellens N, Williams E, Burdette C, Karmarkar P, Weiss CR, Kraitchman DL, Bottomley PA. Intravascular MRI Guided Perivascular Ultrasound Ablation. 12 th Interventional MRI Symposium, Marriott Longwarf, Boston USA, Oct 5-6 2018: 28. https://cdn.website-editor.net/ed4a3740370b414595b38f3fc1951e45/files/uploaded/TOC_IMRI2018.pdf 247. Zhu J, Jiang D, Schär M, Voit D, Frahm J, Bottomley P, Lu H, Liu P. Measuring cerebrovascular reactivity without gas challenge: a real-time phase-contrast MRI approach. Proc. Intl. Soc. Mag. Reson. Med. 2019; 27: 2929. https://index.mirasmart.com/ISMRM2019/PDFfiles/2929.html. XXX ___________________________________

lNVITED LECTURES 1. "Nuclear Magnetic Resonance Imaging", University of Texas Health Science Centre, Dallas, Texas, U.S.A., June 8, 1978. 2. "Body Imaging by Nuclear Magnetic Resonance", College of Engineering, University of California, Berkeley, California,U.S.A., June 9, 1978. 3. "Nuclear Magnetic Resonance Imaging", Department of Physiological Chemistry, The Johns Hopkins University, Baltimore, Maryland, U.S.A., July 25, 1978. 4. "Nuclear Magnetic Resonance Imaging ", National Cancer Institute, Diagnostic Research Advisory Group, Bethesda, Maryland, U.S.A., June 27, 1979. 5. "NMR Imaging in Medicine and Biology", School of Physics, University of New South Wales, Kensington, New South Wales, Austral ia, January 22, 1980.



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6. "Biological Applications of NMR Imaging", Department of Radiology, University of Florida, Gainesville, Florida, U.S.A., March 21, 1980. 7. "MR Imaging and Its Applications ", General Electric Company, Research and Development Centre, Schenectady, New York, U.S.A., April 30, 1980. 8. "Medical and Biological Applications of NMR Imaging", Division of Radiological Sciences, Vanderbilt University Hospital, Nashville, Tennessee, U.S.A..June 10, 1980. 9. "Nuclear Magnetic Resonance Imaging.Some Results and Applications", American College of Radiology Conference on Imaging, Colorado Springs, Colorado. USA, August 6, 1980 10. "NMR imaging; some potential applications"NMR Imaging Symposium, Vanderbilt University, Nashville, Tennessee. October 27, 1980. 11. "Biomedical imaging by nuclear magnetic resonance", The William H. Conklin Nuclear Medicine Association of North East New York, Century House, Latham, New York, USA, October 30, 1980. 12. "NMR in vivo: new frontiers in biomedical imaging", General Electric Corporate Research and Development Centre, Science and Technology Forum, Schenectady, New York, November 11, 1980. 13. "Magnetic Field Exposure in Clinical Nuclear Magnetic Resonance Imaging", XVth International Congress of Radiology, Brussels, Belgium, June 26, 1981. 17. Spin lattice relaxation: What is it? Why is it important? How do you measure it? "2nd Annual Workshop on NMR Imaging. University of Texas, Houston, March 3, 1982 . 21. "NMR imaging principles "2nd Annual Workshop on NMR Imaging, University of Texas, Houston, March 4, 1982. 22. Chairman, Instrumentation Session, Soc. Magn. Reson.in Med. 1st Annual Meeting, Boston, MA, August 16, 1982. 23. "Principles of NMR imaging", 1st Annual Meeting Soc. for NMR Imaging, Colorado Springs, CO, Feb. 15, 19 83 ; Physics Tutorial, Feb 15; Chairman, Advance Lectures Section, Feb. 16, 1983. 24. "NMR imaging and in vivo spectroscopy" Japanese Neuroradiology Meeting, Tokyo, Japan, Feb. 25, 1984. 29. "NMR instrumentation". Soc. Magn. Reson. Imaging 2nd Annual Meeting, Orlando, Fla., Feb. 27, 1984. 30. "Introduction to and application of in vivo chemical shift NMR spectroscopy", American Association of Physicists in Medicine, South California Chapter Spring Seminar, Las Vegas, Nevada, April 26, 1984. 31. "NMR imaging and in vivo spectroscopy", The Delaware NMR Symposium, Newark, Delaware, May 30, 1984. 32. "NMR in diagnostic medicine", and discussion of future potential of NMR, National Cancer Institute Symposium on research and clinical applications of nuclear magnetic resonance in cancer, New Orleans, Louisiana, June 20-22, 1984. 33. "RF power deposition in NMR imaging". Chairman of session "New Techniques I". Soc. Magn. Reson. Med. 3rd Annual Meeting New York, NY, Aug. 13-17 (1984).


46

34. "The principles of magnetic resonance imaging". NMR discussion group meeting on "The NMR of NMR", London, UK, Sept. 19, 1984. 35. "Localized spectroscopy and imaging techniques". British Radiofrequency spectroscopy group meeting on "Techniques for spatially localized nuclear magnetic resonance", Guildford, UK, Sept. 19-21, 1984. 36. "High resolution NMR imaging and chemical spectroscopy of the body at 1.5 T." 2nd Annual Speziale Seminar series on "Biological Applications of NMR", St. Louis, MO, Oct. 15, 1984. 37. "RF power deposition in NMR imaging: comparison of experiment and theoretical model estimates"; Co-chairman of meeting: Workshop on RF coil energy deposition in NMR, San Francisco, CA, Nov. 7, 1984. 38. "NMR imaging and spectroscopy at 1.5 T". Melbourne Australia, Dec. 17 1984; University of NSW, Sydney, Australia, Dec. 19, 1984; Royal North Shore Hospital Sydney Australia, Dec. 19, 1984; Austin Hospital, Melbourne, Australia, Jan 11, 1985. 39. "Techniques and applications of in vivo localized chemical shift spectroscopy", Dept. of Radiology, Michigan State University, East Lansing, MI, Mar. 5, 1985. 40. "Chemical shift imaging techniques and applications", 3rd Ann. Meeting Soc. Magn. Reson. Imag. San Diego, CA, March 22-26, 1985. 41. "Techniques and applications of localized phosphorus and hydrogen NMR spectroscopy in vivo, Biochemistry Dept. Albany Medical College, Albany, NY, May 20, 1985. 42. "High field NMR imaging and spectroscopy". NATO Advanced Study Institute School on NMR in the Life Sciences, Erice, Sicily, June 19, 1985. 43. "The combination of NMR imaging and spectroscopy in human subjects". University of California, San Francisco, VA Medical Center, Dept. of Medicine, San Francisco, CA, July 10, 1985.

44. "Towards clinical 31P spectroscopic imaging", Soc. Magn. Reson. Med. 4th Ann. Meeting, London UK, Aug. 24, 1985. 45. "Localized NMR spectroscopy in vivo 53rd Semi annual Symposium on the Physics of Medical Imaging, NY State Section, American Physical Society, Schenectady, NY, Oct. 4, 1985. 46. "Towards clinical application of in vivo NMR chemical shift spectroscopy", East Carolina University School of Medicine, Radiation Oncology Centre, Greenville, NC, Oct. 14, 1985. 47. "NMR chemical shift spectroscopy in man", Rensselaer Polytechnic Institute, Dept. of Biological Engineering, Troy, NY, Nov. 12, 1985. 48. "Techniques and applications of NMR chemical shift imaging in vivo" 24th Eastern Analytical Symposium, New York, NY, Nov. 21, 1985. 49. "In vivo NMR spectroscopy" invited lecture tour of Japan speaking at University Hospitals in Fukuoka, Niigata, Tokyo, and Wakayama (Osaka), sponsored by Yokogawa Medical Systems, Tokyo, Japan. Feb. 1986.

50. "Clinical applications of localized 31P spectroscopy", Soc. Magn. Reson. Imag. 4th Ann. Meeting, Philadelphia, PA, Mar 5, 1986.


47

51. "Towards clinical application of in vivo NMR spectroscopy", Depts. of Diagnostic Radiology and Molecular Biophysics and Biochemistry, Yale University, New Haven, CN, April 2, 1986. 52. "Localized NMR spectroscopy in man" Applied Physics Laboratory, Johns Hopkins University, Laurel, MD, April 11, 1986. 53. "Towards clinical applications of in vivo NMR spectroscopy" Roswell Park Memorial Institute, Buffalo, NY, May 14, 1986. 54. "A practical guide to getting NMR spectra in vivo" Teaching lecture at the 5th Ann. Meet. Soc. Magn. Reson. Med., Montreal, CA, Aug. 18, 1986. Session Chairman, "Clinical Implications" Aug. 21, 1986. 55. "Spatial localization in NMR spectroscopy in vivo". New York Acad. of Sciences Meeting on Physiological NMR spectroscopy: from isolated cells to man, New York, NY, Sept. 26, 1986. Session Chairman, Evening Tutorial, Sept 25, 1986. 56. "An introduction to in vivo NMR spectroscopy for clinical applications" Joint Radiological Society of North America (RSNA), Am. Association of Physicists in Medicine Symposium, 72nd RSNA, Chicago, Ill., Dec. 4, 1986. 57. "Spectroscopy localization techniques", Educational Program, Soc. Magn. Reson. Imaging. 5th Annual Meeting, San Antonio, TX, March 1, 1987. 58. "Techniques for clinical in vivo spectroscopy" Spectroscopy Scientific Symposium, Soc. Magn. Reson. Imaging 5th Annual Meeting, San Antonio, TX, March 4, 1987. 59. "NMR spectroscopy and imaging in biology and medicine" NMR in the Life Sciences Seminar, Dept. Biol. Chem., University of California, Davis, CA., April 3, 1987. 60. "MRS of Heart" Tutorial on In Vivo Magnetic Resonance Spectroscopy, Dept. Radiol. University of California, San Francisco, CA, April 3, 1987. 61. "Localization techniques using Bo gradients", and session chairman, Workshop on Magnetic

Resonance Spectroscopy In Vivo, Dept. Radiol. University of California, San Francisco, CA, April 4, 1987. 62. "Relaxation measurements and tumors", 6th Ann. Meet. Soc. Magn. Reson. Med., New York, NY, Aug. 18, 1987. 63. "Variations and dependence in experimental measurements", National Cancer Institute Workshop on NMR relaxation mechanisms in biological tissues, Bethesda, MD, Nov. 10, 1987. 64. "Techniques and applications of phosphorus in vivo NMR spectroscopy", Mini-symposium on applications of NMR to living systems, State University of New York, Albany, Center for Biochemistry & Biophysics, Nov. 13, 1987.

65. "Noninvasive localized 31P NMR spectroscopy in the heart: canine and human studies: Depts. of Radiology and Cardiology Johns Hopkins University School of Medicine, Baltimore, MD, Nov. 23, 1987. 66. "Future directions for in vivo NMR spectroscopy and NMR imaging" The 1988 George Burch Lecture of the Association of University Cardiologists, New Orleans LA, Jan. 21, 1988. 67. "In vivo NMR spectroscopy in diagnostic medicine: clinical tool or research probe?" The 1988 David Gould Lecture, Johns Hopkins University School of Medicine, Baltimore, MD, May 3, 1988.


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68. "Clinical in vivo spectroscopy: techniques, applications and findings". The 1988 ANZAAS (Australian and New Zealand Association for the Advancement of Science) Centenary Congress, University of Sydney, Sydney Australia, May 16, 1988. 69. "2D selective pulses and 3D spectroscopic imaging; and for discussion: on the definition of a spatially localized volume". The Joint International Society of Magnetic Resonance and National Institutes of Health in vivo NMR Research Center Workshop on emerging technologies for simultaneous spatial and spectral resolution in in vivo NMR, Bethesda, MD, June 17, 1988. 70. Session Chairman "Quantitative spectroscopy" 7th Ann. Meet. Soc. Magn. Reson. Med., San Francisco, CA, August 25, 1988. 71. "In vivo studies of body chemistry by NMR", Rennselear Polytechic Institute, Troy, NY, Dec. 16, 1988. 72. "NMR spectroscopy of the human heart", National Institutes of Health, Bethesda, MD, April 19, 1989. 73. "NMR spectroscopy of normal and diseased human heart metabolism". Harvard Medical School Course, "Modern Cardiac Imaging", Dept. Radiology, Boston, MA, May 5, 1989. 74. "In vivo NMR spectroscopy" Radiology Dept., Frankfurt University, Frankfurt FRG, June 28, 1989. 75. "Problems and expediances in human 31P spectroscopy: the definition of localized volumes, dealing with saturation, and the technique dependence of quantitation", Workshop on "Localized NMR spectroscopy in vivo. Problems, strategies, and applications". Max-Planck-Institut fur Biophysikalische Chemie, Gottingen, FRG, June 29, 1989. Session chairman June 30, and member of the Scientific Committee. 76. Session Chairman, "Human spectroscopy" 8th Ann. Meet. Soc. Magn. Reson. Med., Amsterdam, The Netherlands Aug. 17, 1989. 77. "Probing energy metabolism in vivo with phosphorus nuclear magnetic resonance. Clinical research findings in the brain and heart". Grand Rounds, Albany Medical Center, Neurology Dept., Albany, NY, Jan. 25, 1990. 78. "Application-driven spatial localization protocols for clinical spectroscopy in the heart and brain". Joint SMRI-SMRM Symposium on spectroscopy, Washington, DC, Feb. 25, 1990. 79. "Clinical applications vs localization strategies for 31P NMR research: from the heart to the brain". The Royal Society meeting on "NMR imaging: recent developments and future prospects", Royal Society, London UK, June 6, 1990. 80. "Recent perspectives on clinical in vivo spectroscopy research". London NMR discussion group, Royal College of Surgeons, London UK, June 8, 1990. 8l. "Brain high energy phosphate metabolism in dementias". French Foundation Workshop on "Silent vascular disease, dementia and spectroscopy, Los Angeles CA, Aug. 3, 1990. 82. "Strategies for 31P quantitation in brain and heart". GE SIGNA spectroscopy users meeting, New York NY, Aug. 19, 1990. 83. "Clinical magnetic resonance spectroscopy of the heart". Teaching session, Society for Magnetic Resonance in Medicine 9th Annual Meeting, New York NY, Aug. 19,1990. 84. "Assessment of myocardial ischemia in patients with coronary artery disease by P-31 stress-testing." Division of Cardiovascular Disease, University of Alabama, Birmingham AL, Oct. 16, 1990.


49

85. "Localization strategies for in vivo human chemical shift spectroscopy". The 29th Eastern Analytical Symposium, Somerset NJ, Nov. 13, 1990. 86. "Homogeneous tissue model estimates of RF power deposition in human NMR studies. Local elevations predicted in surface coil decoupling". The New York Academy of Science on Conference on "Biological effects and safety aspects of nuclear magnetic resonance imaging and spectroscopy, Bethesda MD, May 16, 1991. 87. "Hearts, brains and quantification". GE SIGNA spectroscopy users meeting, San Francisco CA, Aug. 11, 1991. 88. "Forum in quantitative spectroscopy: what is the true PCr/ATP ratio in the normal human heart?" Session Organizer, Chairman and participant, Society for Magnetic Resonance in Medicine 10th Annual Meeting, San Francisco CA, Aug. 12, 1991. 89. "Clinical examples of spectral quantification", Mini-categorical course on "Spatial Localization, Methods and Spectral Quantification", Society of Magnetic Resonance in Medicine, 10th Annual Meeting, San Francisco CA, Aug. 16, 1991. 90. Session Chairman, "Cardiac spectroscopy", Society of Magnetic Resonance in Medicine, 10th Annual Meeting, San Francisco CA, Aug. 12, 1991. 91. "Phosphorus NMR for studying energy metabolism in human heart: problems, solutions and clinical findings". Perspectives in magnetic resonance: frontiers in biochemistry and physiology. Symposium celebrating 75th Anniversary of the National Research Council, Ottawa Canada, Oct. 7, 1991. 92. "In vivo phosphorus NMR spectroscopy in the clinic: diagnostic tool or research probe?" University of Michigan, Dept of Electrical Engineering and Computer Science Seminar Course, Ann Arbor MI, Oct 24 1991. 93. "Quantitative NMR spectroscopy of human heart." Presented at the AHA/SMRM sponsored, Scientific Conference on the Application of Magnetic Resonance to the Cardiovascular System, Dec 15-18, 1991, Atlanta GA. 94. "Quantitative in vivo phosphorus NMR spectroscopy in the heart and brain: diagnostic tool or research probe?" Plenary lecture, 19th Annual Meeting of the Japanese Society of Magnetic Resonance in Medicine, Tokyo, Japan, Mar 23-24, 1992. 95. "The dedication of NMR to the human being". Yokagawa Medical Systems, Hino, Tokyo, Japan Mar 25 1992. 96. "Quantifying human cardiac and brain energy metabolism in normal and disease states with phosphorus NMR spectroscopy". British Radio-spectroscopy Group Conference, Nottingham UK, April 12-15 1992. 97. "Human in vivo NMR spectroscopy: clinical tool or research probe? Also session chairman and organizer of 3 workshops: "Biomedical imaging I: DC-10 MHz", "Biomedical imaging II: 1-500 MHz", and Biomedical imaging III: 0.1 THz and above". Science Innovation '92: new techniques and instruments in biomedical research. American Association for the Advancement of Science, San Francisco CA, July 21-25, 1992. 98. Session Chairman, "MRS of brain: animal and cellular models" Society for Magnetic Resonance in Medicine 11th Annual Meeting, Berlin, Germany, Aug. 12, 1992. 99. "Phosphorus NMR of heart patients", Michaelmas Term 1992 Seminar Series, Department of Biochemistry, University of Oxford UK, Nov 20, 1992


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100. "Phosphorus NMR spectroscopy in the brains of patients with dementia and in the hearts of cardiac patients". Royal Postgraduate Medical School, Hammersmith Hospital, London UK, Nov 23, 1992. 101. "Human spectroscopy". Presented at "St George's MRI Symposium, MRI: its Role in Diagnosis", St George's Hospital, London UK, 26th Jan 1993. 102. "MR spectroscopy". Presented at "MR'93, 5th International Nuclear Spin Tomography Symposium", Garmisch-Partenkirchen, Germany, Jan 30 1993. 103. "Phosphorus NMR spectroscopy in human heart: current status of clinical studies". Presented at the 2nd Course on MR Angiography and Cardiovascular Imaging, University of Leiden, The Netherlands, Mar 5, 1993. 104. "Energy metabolism in human heart and brain: patient studies with phosphorus NMR spectroscopy". Presented at the Department of Medicine University of Liverpool Seminar Series, Liverpool, UK, April 21 1993. 105. "The mystery of proton T1 in tissue". Department of Biochemistry, Oxford University, Oxford, UK, May 11, 1993. 106. “Mapping biochemicals in the body”. Also session co-chairman and co-organizer of the workshop: "Functional magnetic resonance imaging". Science Innovation 1993, conference on new research techniques. American Association for the Advancement of Science, Boston MA, Aug 6-10, 1993. 107. “Standardization, quantification and reproducibility in NMR spectroscopy”. Also, co-moderator, session on: “Assessment of measurement sensitivity, signal-to-noise and spatial resolution”. Workshop on standardization in clinical MRS measurements. New York, Aug 13, 1993. 108. "Human cardiac spectroscopy: the status and the challenges (plenary lecture)”. Also session co-chairman: “Advanced techniques for brain MRS”. 12th annual meeting of the Society of Magnetic Resonance in Medicine, New York, USA, Aug 1993. 109. “Cardiac spectroscopy”. Department of Radiology, Albany Medical Center, Albany NY, Feb 11, 1994. 110. “Whither human cardiac spectroscopy” 1st Nottingham Symposium on Magnetic Resonance in Medicine, University of Nottingham, Nottingham UK, April 7, 1994. 111. Session Chairman: “Cardiac spectroscopy: human and animal”, 2nd meeting of the Society of Magnetic Resonance, San Francisco CA, USA, Aug 8 1994. 112. “Human cardiac NMR spectroscopy”. Plenary lecture, Annual Meeting of the Japanese Society of Magnetic Resonance in Medicine, Osaka, Japan, Sep7, 1994. 113. “Whither human cardiac NMR spectroscopy”. Radiology Research Colloquium Series, Department of Radiology, Johns Hopkins University, Baltimore MD, Sept 13, 1994. 114. “Acquiring regional biochemical information from the body with NMR: how and why”. Plenary lecture, Medical Imaging Conference (Nuclear and Plasma Sciences Society of the Institute of Electrical and Electronic Engineers), Norfolk VA, Nov 3, 1994. 115. “Human in vivo NMR spectroscopy: how can it be useful?” Presented at the special focus session, “ Clinical spectroscopy: how can it be useful”, 80th Scientific Assembly and Annual Meeting, Radiological Society of North America, Chicago IL, Nov 30 1994. Radiology 1994; 193P; 32.


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116. Session Chairman “Heart-Energetics”, and member, Organizing Committee, Workshop on Advances in Physiological Chemistry by in vivo NMR, Marine Biological Institute, Woods Hole MA, Mar 22-24, 1995. 117. “Quantification of myocardial 31P MRS in man”, American Heart Association Scientific Conference on Current and Future Application of Magnetic Resonance in Cardiovascular Disease, San Francisco CA, Jan 15, 1996. 118. Session co-chairman, “Cardiovascular and abdominal MR spectroscopy”, 4th Scientific Meeting and exhibition, International Society for Magnetic Resonance in Medicine, New York NY, May 2 1996 119. “Progress in human cardiac spectroscopy”, state-of-the-art lecture, 2nd International Symposium, Magnetic Resonance in Cardiovascular Research, Wurzburg Germany, June 1, 1996. Session Moderator, May 31, 1996 120. “Clinical potentials of MR measures of myocardial metabolism”, NHLBI working group on MRI in clinical cardiology meeting “Magnetic Resonance Imaging in Clinical Cardiology”, NHLBI, Bethesda Oct 28-29 1996. 121. “The rise of in vivo NMR spectroscopy”, E Raymond Andrew 75th Anniversary Symposium, Gainesville Florida, Jan 5 1997. 122. “New metabolic probes of viability: creatine depletion in myocardial infarction, and progress in direct metabolic imaging with magnetic resonance". Grand Rounds, Department of Radiology, Johns Hopkins University, Baltimore, Oct 14, 1997. 123. “The rise of human in vivo spectroscopy”. Plenary lecture, Annual Meeting of the Korean Society for Magnetic Resonance in Medicine, Seoul Korea, Nov 1 1997. 124. “Cardiac MR: the new frontier”. Plenary lecture, Annual Meeting of the Korean Society for Magnetic Resonance in Medicine, Seoul Korea, Nov 1 1997. 125. “Clinical utility of proton and 31P NMRS for heart failure”. Invited lecture, First annual meeting, Society for Cardiovascular Magnetic Resonance, Atlanta GA, Jan 31 1998. 126. “MRS of the human heart”. Invited lecture, Introductory spectroscopy course, 6th Scientific Meeting, International Society for Magnetic Resonance in Medicine (ISMRM) Sydney Australia, April 19, 1998. 127. “Measurement of creatine kinase metabolites in human heart”. Invited lecture, Dynamic NMR spectroscopy session, 6th Scientific Meeting, International Society for Magnetic Resonance in Medicine (ISMRM) Sydney Australia, April 20, 1998. 128. “Human cardiac spectroscopy”. Magnetic resonance in Cardiovascular Research, 4th Scientific Meeting and Teaching Course, Wurzburg Germany, Sept 24-26, 1998. 129. “How to do clinical studies with MR of nuclei other-than-hydrogen” Invited lecture, Second annual meeting, Society for Cardiovascular Magnetic Resonance, Atlanta GA, Jan 22 1999. 130. “Quantifying and imaging metabolites directly at 1.5 T”. National Cancer Institute focus group on 1H and 31P magnetic resonance spectroscopy in clinical oncology, Rockville MD, April 22, 1999. 131. “Clinical MRS of nuclei other-than-hydrogen” Invited talk, Clinical Spectroscopy course, 7th Scientific Meeting, International Society for Magnetic Resonance in Medicine (ISMRM), Philadelphia PA, May 22, 1999.


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132. “1H-MRS: a new window into energetics”. Invited talk, Cardiovascular Seminar 55. American Heart Association 72nd Annual Meeting, Atlanta GA, Nov 8 1999. 133. “Quantification and imaging of human myocardial phosphorus, proton and sodium metabolites”. Invited talk, and Session Chairman, Society for Cardiovascular Magnetic Resonance, 3rd Annual Meeting, Atlanta GA, Jan 21 2000. 134. “MRI at the leading edge: high speed and high resolution”. Society of Cardiovascular & Interventional Radiology, 25th Annual Meeting, San Diego Mar 27, 2000. 135. “Quantification and imaging of myocardial sodium and creatine kinase metabolites”. 5th International Symposium on magnetic resonance in cardiovascular research Marseille, France, September 8-9, 2000. 141 “Cardiovascular MRI probes for the outside in and for the inside out”. 5th International Symposium on magnetic resonance in cardiovascular research Marseille, France, September 8-9, 2000. 142. “Ischemia: MRS Perspective”. Plenary Session IV: MR/MRS, Jan 27, 2001. Session moderator, “Real-time MR”, and at “Cardiac MR and MRS”, Jan 27, 2001. Society for Cardiovascular Magnetic Resonance, 4th Annual Meeting, Atlanta GA, Jan 26-28, 2001. 143. “Creatine kinase reaction kinetics in humans: the final frontier for quantitative 31P MRS”. 6th International Sypmosium on MR in Cardiovascular research, Oxford University, UK, Mar 22-23, 2002. 144. “Safety and internal MRI coils”. Radiological Society of North America (RSNA) special cross-specialty categorical course in Diagnostic Radiology: practical MR safety considerations for physicians, physicists, physicists and technologists. Nov 27 2001. 145. “Magnetic Resonance Cardiac Spectroscopy”. JHU-GE Cardiac MRI Meeting, Division of Cardiology, Johns Hopkins University, Feb 11 2002. 146. Session Chairman, “Cardiovascular MR spectroscopy”, 10th Scientific Meeting and Exhibition, International Society for Magnetic Resonance in Medicine, Honolulu HI, May 23 2002. 147. “Safety and internal MRI coils”. Radiological Society of North America (RSNA) special cross-specialty categorical course in Diagnostic Radiology: practical MR safety considerations for physicians, physicists, physicists and technologists #428.B. Dec3 2002. 148. “Of MRI, the exile of nuclei, and thirty year wars.” 45th ENC Conference, April 21, 2004. “Wednesday Oral Session E: Celebrate the Magnetic Resonance Nobel Tradition”. Asilomar CA. 149. “Cardiac spectroscopy in 2005”. 8th Annual Scientific Sessions of the Society for Cardiovascular Magnetic Resonance, San Francisco CA, Jan 22 2000. 150. “Safety of Internal coils”. Philips MR Interventional Council, Conference Center Groenendael, Hilvarenbeek, The Netherlands, February 3 2005. 151. “Interventional CMR: Device Safety”. 9th Annual Scientific Sessions of the Society for Cardiovascular Magnetic Resonance, Miami FL, Jan 21 2006. 152. “Patents and Intellectual Property-what I know about it”. MR Research Seminar Series, Department of Radiology, Johns Hopkins University, 3/30/06. 153. “Imaging sodium content in patients with heart disease and cancers”. New York Academy of Sciences, Frontiers of Science series, New York Academy of Sciences, New York April 20 2006.


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154. Session Chairman. “Experimental Cardiac MRI.” International Society for Magnetic Resonance in Medicine, Seattle WA, May 8 2006. 155. “Interventional MRI device safety”. Guidant Corporation, Minneapolis MN, 9/7/06. 156. “MRS of the heart”. ISMRM Workshop on Data Processing for MR Spectroscopy and Imaging 11-13 Nov 2006, Warrenton VA. 157. Rapporteur,” Technical Challenges of High Field CMR”, Sept 21 2006. Speaker, “Summary, Technical Improvements”, Sept 22 2006. In: “High Field Cardiovascular MR: The Promise, The Problems, The Potential Solutions", Symposium, September 21-22 at the Washington, DC. 158. “Evaluation of Myocardial metabolism”. ISMRM Global Outreach Program in conjunction with the Turkish Society of Magnetic Resonance “Cardiovascular MR Imaging Symposium”, Antalya, Turkey, April 5. 2007. 159. “Novel Cardiac MR Technologies”. ISMRM Global Outreach Program in conjunction with the Turkish Society of Magnetic Resonance “Cardiovascular MR Imaging Symposium”, Antalya, Turkey, April 5. 2007. 160. “Cardiac Spectroscopy”. Philips Spectroscopy Council Meeting, Berlin Germany, May 25 2007. 161. “Devices”, speaker and discussion group participant, 8 th Siemens Cardiovascular Interventional MR Workshop, Potsdam Germany, May 26 2007. 162. "Measuring Energy Supply in Normal, Stressed, Failing, Cardiomyopathic and Infarcted Human Hearts by Noninvasive Phosphorus MRS", Grand Rounds, Dept. of Radiology, Johns Hopkins University, Baltimore MD, Sept 6 2007. 163. Panelist, Applications Update, Workshop on high-field cardiac MR, Jan 31 2008, Los Angeles CA. 164. “Intravascular Devices at 3T”. Society for Cardiovascular Magnetic Resonance, 11th Annual Scientific Meeting, Los Angeles CA, Feb 3 2008. 165. Session co-chairman, “Molecular MRI Monitoring of Therapy and Disease”, ISMRM 16 th Annual Meeting, Toronto Canada, May 8 2008. 166. Session co-chairman, “Percutaneous Hybrid Procedures, Navigation, Robotics”, Seventh Interventional MRI Symposium, Baltimore, MD, Sept 13th 2008. 166. “iCMR Intravascular Devices: Safety, High-Field, Intravascular”, Society for Cardiovascular Magnetic Resonance, 12th Annual Scientific Meeting, Orlando FL, Jan 31 2009. 167. “MR-endoscopy, MRI-safe implantable lead design, and SAR dosimetry”. Philips Interventional MRI Council 2010, Leipzig Germany, September 22 2010. 168. Panelist, “Musculoskeletal interventional procedures and surface coils for interventional MR”. 10th Siemens Interventional MR Workshop, Leipzig, Germany, Sept 26, 2010. 169. Visiting Professor, Centre de Résonance Magnétique Biologique et Médicale (CRMBM), Université de la Méditerranée, Marseille, France, Jun 4-July 16, 2011. Lectures:

a. “Energy supply and the failing human heart”. Jun 7; b. “Tools of the trade: Why and what you need to know about adiabatic pulses, Part I”, Jun 21; c. “Tools of the trade: Why and what you need to know about adiabatic pulses, Part II”, June 22; d. “Getting more (SNR) with less (time) with pre-selective spatial encoding,” Jun 28;


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e. “Intravascular MRI endoscopy”, July 13 2011. 170. “Anatomy and metabolism by MR thirty years later”. Societe Francaise de Resonance Magnetique en Biologie & Medicine Inaugural Congress, and Centre de Resonance Magnetique Biologique et Medicale Silver Jubilee, Marseille France, Mar 22, 2012. 171. “Localized Origins”. The 2012 Sir Peter Mansfield Lecture, of the 20th Annual Society of Magnetic Resonance in Medicine Conference in Melbourne Australia, May 10, 2012. 172. “Predicting the Future”. The 9th International Interventional MRI Symposium, JB Martin Conference Center, Harvard Medical School, Boston MA, Sept 22, 2012. 173. “Localized Origins”. Opening plenary lecture, Section for Magnetic Resonance Technologists (SMRT), Salt Lake City, UT, USA, April 20 2013. 174. “Introduction to Cutting-Edge Cardiac MRI.” 21st Annual Society of Magnetic Resonance in Medicine (ISMRM), Salt Lake City, UT, USA, April 25, 2013. 175. “Localized Quantification”. Philips MR Clinical Science teleconference, April 14 2014. 176. “A Special Tribute to Dr. William A. Edelstein”. MR Imaging Study Group Meeting of the 22nd Annual Society of Magnetic Resonance in Medicine (ISMRM), Milan, Italy, May13, 2014. 177. “RF-Testing of Clinical Leads, Catheters & Probes for MRI & on Methods for RF-Proofing Them”. ISMRM Scientific Workshop. “Safety in MRI: Guidelines, Rationale & Challenges”. Washington, DC, USA, Sept. 7 2014. 178. “MRI endoscopy: a path to high resolution parametric imaging and intervention”. 10th Interventional MRI Symposium-iMRI 2014, Leipzig, Germany Oct 10, 2014. Session Moderator: “Pelvis/Technology/General Issues”, Oct 10, 10:35-12:25. 179. "MRI Endoscopy at Microscopic Resolution: The MR-Eye”. 4th Annual Hopkins Imaging Conference, Nov 5 2014, Turner Auditorium, Johns Hopkins Medical Institution, Baltimore MD. 180. “Cardiac Spectroscopy”. SCMR/EuroCMR Joint Scientific Sessions Nice Acropolis, Nice, France Feb 7, 2015. 181. “What MR spectroscopy says about ATP energy supply in heart disease and failure”. British Heart Foundation Seminar, Cardiovascular Division & King’s BHF Centre of Research Excellence, King’s College London, Feb 9 2015. 182. “R&D: high resolution MRI-guided interventions with multi-functional IV probes.” 2nd Annual Joint Johns Hopkins–Siemens Workshop on MRI, Johns Hopkins Dept of Radiology, Baltimore MD, May 12, 2015. 183. “SLAM everything: massive speed-ups enabling organ –or pathology-average measurements”. 3rd Annual Joint Johns Hopkins–Siemens Workshop on MRI, Johns Hopkins Dept of Radiology, Baltimore MD, Jun 8 2016. 184. "MR spectroscopy, endoscopy and microscopy: less space in less time” Biomedizinische NMR Forschungs GmbH am Max Planck Institute fuer biophysikalische Chemie Goettingen, Germany, Aug 9 2016. 185. "MRI endoscopy, and highly-accelerated MRI parametry: SLAM for everything.” Siemens, Inc, Erlangen, Germany, Aug 11 2016.


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186. “SLAM & Co.” ISMRM Workshop on “MR Spectroscopy: From Current Best Practice to Latest Frontiers”, Lake Constance, Germany, 16 Aug 2016. 187. “Learning from the unexpected: Do you run with it or away?” 4th Annual Retreat of the CIBM-CHUV MR group, Lac d’Annecy, Sevrier, France, Sept 7 2016. 188. Session organizer and co-moderator: “As Yet Unseen: Industry Advances in Neuro‐Interventions” 11th International MRI symposium, Oct 7-8 2016, Baltimore MD. 189. “Magnetic Resonance Imaging from the inside”. FIAP Plenary: Physics that Changed the World. American Physical Society, Annual Meeting, New Orleans LA, Mar 15 2017. 190. Session co-chairman, “Non-Proton MRI & MRS”, ISMRM 25th Annual Meeting, Honolulu HI, Apr 25 2017. 191. "Research Rules of Thumb: Learning from the Unexpected". CME translational research conference, Johns Hopkins University Dept of Radiology, Baltimore MD, May 9, 2017. 192. "Cardiac MRS: A new life for an old dog." The 2017 Radda Symposium, Eynsham Hall, Oxford UK, Jun 26 2017. 193. "Fast, High-SNR Spectroscopy of Tissue Compartments with SLAM". Symposium on "Breaking the Spatiotemporal Limits of MRSI", Intl Soc Mag Reson Med. June 20, 2018. 194. “The power of the heart: energy supply & failure” Newton-Abraham Lecture 2019 (public). Oxford Museum of Natural History Oxford UK, Jan 16 2019. 195. Newton Abraham Visiting Professor, Lincoln College, Oxford Sept 2018-Mar 2019. OCNMR seminars John Radcliffe Hospital, Oxford UK:

a. “Predicting cardiac disease & severity with CK metabolism and a neural network”, Oct 16 2018;

b. “Cardiac work is related to creatine kinase energy supply in human heart failure”, Nov 21, 2018;

c. “Localised spectroscopy of whole compartments for maximum efficiency and speed using the linear algebraic method (SLAM)” Dec 5, 2018;

d. “Patently not obvious–sharing experience on patents and patenting”, Dec 19 2018; e. “Intravascular MRI endoscopy and image-guided intervention using tiny MRI probes” Jan 9,

2019; f. "Minimum acquisition methods for measuring and imaging T1, T2 and proton density" Jan 23,

2019; g. “Localised spectroscopy of whole compartments for maximum efficiency and speed using the

linear algebraic method (SLAM)” Feb 5, 2019; h. “RF heating from MRI, and stopping it”, Feb 20,2019.

196. "Heart Work, Energy Supply and Intravascular Intervention: Magnetic Resonance for all!" Cambridge Radiology Forum, Addenbrooke's Hospital, University of Cambridge UK, Feb 27 2019.

197. Session co-chairman, “Mini Symposium 1 Advances in Device Navigation”, 2nd SIGN (Society for image guided neurointerventions) Conference, Baltimore MD USA, June 10 2019.

198. “The power of the heart: energy supply & failure”. Johns Hopkins Radiology Research Day Dec 10, 2019, Baltimore MD, USA.

XXX ___________________________________

MISCELLANEOUS 1. Front cover pictures and captions:


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• Physics Bulletin, July 1977;

• Nature 270, 22-29 December 1977;

• Hospital Physicists Association Bulletin, June 1978;

• Medical Physics, 11 (4), Jul./Aug. 1984;

• Design News 43(8), April 21, 1986;

• Medical Physics 35 (5) May 2008;

• JACC-Cardiovasc. Imag. (2010, in press).

2. Grant Reviewer consultant for: National Cancer Institute, Bethesda MD, June 27, 1979; Site visit committee Philadelphia, PA, June 14-16, 1985 and Philadelphia, PA, June 2-4, 1986; Phone in reviewer 1/31/02. National Heart, Lung and Blood Institute, Berkeley, CA, Jan 27-29, 1980; Bethesda, MD, June 29-July 2, 1979 National Science Foundation, 1984 Veterans Administration 1984; Referee 1997 The New York Academy Sciences 1984, 1990 Montana State, 1984 National Institute of Diabetes and Digestive and Kidney Diseases, New Haven, CT, April 11-13, 1990. The Whitaker Foundation, July 1994, 1997; appointed ad hoc member, Scientific Advisory Committee, Jan 11-12 1998, Jan 6-8 2001, ad hoc reviewer 2/18/02 Molecular and Cellular Biophysics Study Section, NIH, Bethesda MD, Oct 28, 1997. National Institute of Health, ad hoc reviewer: Jun 1997, 1/31/2002 National Institute of Health, 1999 BECON conference organizing committee, Chicago, Sept 14, 1998 The British Heart Foundation, Oxford, UK, Oct 2-3, 1998, Sept 10-11, 1999 National Institute of Health, Diagnostic Imaging study section, June 4-5 2001. Engineering & Physical Sciences Research Council (UK) ad hoc reviewer, 1/8/02. National Institute of Health, Diagnostic Imaging-Imaging Bioengineering Research Partnerships, study section, June 9 2002 National Institute of Health, Special emphasis panel, improvements in imaging methods & technologies study section, June 30-Jul 1 2003. National Institute of Health, Special emphasis panel, Bio-engineering Research Partnerships, study section, Georgetown, Washington DC, June 14 2004.

National Institute of Health, Special Emphasis PanelNational Eye InstituteZEY1 VSN, 2019,

2020.

3. Consultant for the General Electric Corporate Research and Development Center, Schenectady, NY, Aug 1-Sept. 30, 1980; Jul 1994-Dec 1994.

4. Charter Member, Society for Magnetic Resonance in Medicine., Society for Magnetic Resonance Imaging 1982, and the International Society for Magnetic Resonance in Medicine. Member, American Association of Physicists in Medicine, and Society for Cardiovascular Magnetic Resonance.

5. Completed GE "Effective Presentation Course", Dec. 1981, outstanding report.

6. Manuscript referee for J Magn Reson, Radiol, Science, Rev Sci Instrum, Magn Reson Imag, Magn Reson Med, Radiology, Med Phys, New England Journal of Medicine, Lancet, Circulation. Abstract reviewer for: Society for Magnetic Resonance in Medicine, 1982-1997; Society for Cardiovascular MR, 2001-2.

7. Featured in Popular Science, June 1988, pp 75-109, "Sharpest look yet inside the body" by H. Aldersey-Williams.

8. Awarded silver plaque by the Korean Society of Magnetic Resonance in Medicine for plenary lecture, Nov 1 1997.

9. Consultant, advisory group for Maryland Healthcare Product Corporation (State of Maryland). Evaluation of new technologies. 1996-1997.


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10. Appointed to the American Association for the Advancement of Science, Program Committee for the Science Innovation Conferences, 1991, 1992, 1993

12. Columbia University tenure promotion committee 2/27/02

13. Member, Search Committee, Dean of the Whiting School of Engineering, Johns Hopkins University, 2002-2003.

XXX

_______________________ Disclaimer: This document is provided for information purposes only. Every effort has been made to ensure that the information contained herein is correct at the date appearing on the header, but the author doesn’t guarantee that this is the case. Any errors and/or omissions are unintentional, and this CV is subject to correction and revision at any time.

CURRICULUM VITAE - Johns Hopkins Medicine

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