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BRITISH JOURNAL OF ANAESTHESIA

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British Journalof

Anaesthesia

Editor of General Issues

A. A. SPENCEM.B.. Cta-B.. F.F-A.ILC^.

Editor of Postgraduate Educational Issues

R. A. MILLARM.D.. to£>.. F.FJ^JLCJ.

VOLUME 46

1974

Published by

JOHN SHERRATT AND SON LTD

ALTRINCHAM

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© John Sherratt and Son Ltd, 1974

Printed in Great Britain by John Sherratt and Son LtdPark Road, Altrincham, Cheshire WA14 5QQ

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CONTENTS

JANUARY

EDITORIALRetiral of Dr J. E. Riding 1Jaundice and repeated exposure to halothane ... 1

ORIGINALNitrous oxide anaesthesia induced at atmospheric

and hyperbaric pressures. Part I : Measuredpharmacokinetic and e.e.g. data 3W. D. A. Smith, W. W. Mapleson, K. Siebold,M. D. Hargreaves and G. M. Clarke

Nitrous oxide anaesthesia induced at atmosphericand hyperbaric pressures. Part I I : Comparisonof measured and theoretical pharmacokinetic data 13W. W. Mapleson. W. D. A. Smith, K. Siebold,M. D. Hargreaves and G. M. Clarke

Temperature, humidity and mucus flow in theintubated trachea 29A. R. Forbes

The pulmonary equilibration of cyclopropane ininfants and children 35H. Rackow and E. Salanitre

Brain disposition, liver metabolism and behaviouralresponses to barbiturates in inbred "sensitive"and "resistant" mice 43S. Halevy, M. J. Frumin, S. Rosenthal andW. G. Levine

Effect of diazepam on experimentally induced painthresholds 50G. M. Hall, J. G. Whinuam and M. Morgan

CLINICALChanges in serum uric acid related to the dose of

methoxyflurane 54W. F. D. Hamilton and G. S. Robertson

Intravenous administration sets: the effect offlushing and nitration on paniculate contamina-tion 59M. J. Harrison and T. E. J. Healy

Hypoglycaemia in children before operation: itsincidence and prevention 66D. K. M. Thomas

Anaesthesia and renal transplantation: an analysisof fifty-six cases 69D. A. Logan, Helen B. Howie and J. Crawford

Plasma catecholamine concentrations during surgeryin unsupplemented glucocorticoid-treated patients 73H. Kehlet, P. Nikki, A. Jaaxtela and S. Takki

CASE REPORTThe intraoperative management of phaeochromo-

cytoma with total epidural sympathetic blockade 78M. J. Cousins and R. B. Rubin

CORRESPONDENCEThe strange case of the (inadvertent) continuous

spinal 82

BOOK REVIEWSSynopsis of Anaesthesia 28The Challenge of Life-. Biomedical Progress and

Human Values 28The Relaxed Patient: a manual of sedative tech-

niques 53The Puzzle of Pain 53Penthrane in Clinical Anaesthesiology 65

FEBRUARY

EDITORIAL: Primary Examinations 83

Observations during endobronchial anaesthesia.II: Oxygenation 84J. H. Kerr, A. Crampton Smith, C. Prys-Robens,R. Meloche and P. Foex

Tubocurarine requirements and plasma proteinconcentrations in the newborn infant 93Elena Vivori, G. H. Bush and J. T. Ireland

Pulmonary artery catheterization and wedgepressure measurement in the general intensivetherapy unit 97A. A. Gilbertson

Deliberate profound hypotension induced withhalothane: studies of haemodynamics and pul-monary gas exchange 105C. Prys-Roberts, J. W. Lloyd, A. Fisher, J. H.Kerr and T. J. S. Patterson

Ventilatory effects of isoflurane (Forane) or halo-thane when combined with morphine, nitrousoxide and surgery 117C. J. France, M. H. Plumer, E. I. Eger n andE. A. Wahrenbrock

Sciatic nerve block by the anterior approach foroperations on the lower extremity 121F. Magora, B. Pessachovitch and I. Shoham

Brcmchoscopic removal of inhaled foreign bodiesin children 124A. Baraka

A comparison of the pulmonary response to theendotracheal instillation of 0.1 N hydrochloricacid and Hartmann's solution in the rabbit ... 127J. T. Davidson, S. Rubin, Z. Eyal and A. Polliack

A new soluble acetylsalicylic acid derivative in thetreatment of postoperative pain 133W. J. Kweekel-de Vries, Joh. Spierdijk, H.Mattie and J. M. H. Hermans

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VI CONTENTS

Upper limits of resistance of apparatus for inhalationanalgesia during labour 136Judith M. Davits, M. I. J. Hogg and M. Rosen

The resistance of Entonox valves 145Judith M. Davits, M. I. J. Hogg and M. Rosen

Proposed upper limit of respiratory resistance forinhalation apparatus used in labour 149M. J. J. Hogg, Judith M. Davies, W. W.Mapltson and M. Rosen

Changes in urine osmolality and urine fluorideconcentrations following methoxyflurane anaes-thesia 153G. S. Robertson and W. F. D. Hamilton

Blood-gas changes with different end-expiratorypressures in patients with chronic bronchitis ... 159A. Esteban, F. J. de Elio, E. Cerdd, E. Gdmez-Acebo and P. AncUlo

CASE REPORTSElapid snake bite 162

F. F. Casale and S. M. PaulContinuous lumbar epidural block in labour in the

presence of a Meureig Williams plate fromL1-L4 163J. B. Walpolt

Inferior vena caval occlusion in the left lateralposition 165J. Malatinsky and T. Kadtic

CORRESPONDENCENitrous oxide and intracranial pressure 116A technique of orotracheal intubation 144Concentrations of diazepam in adipose tissue of

children 168Doxapram hydrochloride 169Changes in arterial Po3 in one lung anaesthesia ... 170

BOOK REVIEWSExtrasystoles and Allied Arrhythmias 104Obstetric Analgesia and Anaesthesia 148Muscle Relaxants 167

MARCH

EDITORIAL: Physical chemistry in anaesthesia? 171

PHYSICAL CHEMISTRYPhysical chemistry applied to anaesthetic action 172

M. J. HaUeyAnaesthetic molecules ... ... ... ... 181

F. G. Rudo and J. C. Krantz jrIntermolecular forces 190

K. W. MillerEffects of changes in temperature and pressure

during experimental anaesthesia ... ... 196D. C. White and M. J. Halsey

Transfer of nitrous oxide into body air cavities ... 202E. S. Munson

Radionuclidic techniques ... ... ... ... 217P. W. Horton

SI units in relation to anaesthesia ... ... ... 236G. R. A. Padmore and J. F. Nunn

BOOK REVIEWSDrugs in Anaesthetic Practice ... 201Pain Relief in Labour ... ... ... ... 201Anaesthesia and the EM.O. System 216Notes on Radiological Emergencies 235Pathological and Pharmacological Considerations

in Anesthesiology ... 245Biostatistics in Pharmacology 245Anaesthesia and Uncommon Diseasts: Patho-

physiologic and Clinical Correlations ... ... 246The Neurophysiological Background for Anaes-

thesia 246

CORRESPONDENCEBenzoctamine ... ... ... ... ... 189An adverse reaction to Althesin ... 209Reactions to intravenous agents (Althesin and

pancuronium) ... ... ... ... ... 244

APRIL

EDITORIAL: The pursuit of a chimera ... 247

ORIGINAL AND CLINICALThe blood gas factor: a comparison of three

different oxygen electrodes ... 249B. D. Bird, J. Williams and J. G. Whitwam

Evaluation of a new thin film tonometer ... ... 253C. Chalmers, B. D. Bird and J. G. Whitwam

Infection hazard from syringes ... 260C. E. Blogg, M. A. E. Ramsay and J. D. Jarvis

Acid-base changes in arterial blood and cerebro-spinal fluid during craniotomy and hyperven-tilation ... ... ... ... ... ... 263T. V. Campkm, R. G. Barker, M. Pabari andL. H. Grove

Comparison of Althesin and thippentone in anaes-thesia for paediatric out-patient otology ... 268Laila Saamivaara

Aetiology of prolonged apnoea after suxame-thonium ... ... ... ... ... ... 273H. W. Bauld, P. F. Gibson, P. J. Jebson andS. S. Brown

Pancuronium in maternal and foetal serum ... 282G. A. H. Heaney

Neuroleptanaesthesia for major surgery: experi-ence with 500 cases 288M. Morgan, Jean Lumley and I. D. S. Gillies

Haemodynamic effects of diazepam used as asedative for oral surgery ... ... ... ... 294J. L. Jenkmson, W. R. MacRae, D. B. Scottand J. F. Gould

Thermodynamics of biological processesJ. G. Morris

210APPARATUS

Acceptability of swivel connectors ...Anita Holdcroft, L. Loh and Jean Lumley

298

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CONTENTS Vll

An electronic respirometer ... ... 302L. A. Cox, A. P. Almeida, J. S. Robinson andJ. K. Hartley

CASE REPORTSAnaesthetic management of abdominal distension 311

P. K. Datta, P. D. Jain and D. SharmaTranstracheal ventilation in paediatric patients ... 313

R. B. Smith, E. N. Myers and H. Sherman

P R O C E E D I N G S OF T H E A N A E S T H E T I CRESEARCH S O C I E T Y : London Meeting,March 30, 1974 315

C O R R E S P O N D E N C EHyperpyrexia caused by trimeprazine ... ... 252Obstruction to endotracheal tubes ... ... ... 252T h e Lewin report ... ... ... ... ... 281Bronchospasm induced by Altbesin and pancu-

ronium bromide ... ... ... 281Solubility coefficients for inhaled anaesthetics for

water, oil and biological media ... ... ... 310Patient air intake valve 310A simple and reliable warning device for failing

oxygen pressure ... ... ... 323Circulatory effects of sodium nitroprusside ... 323Toxicity of sodium nitroprusside 324F.F.A.R.C.S. examination 324

BOOK REVIEWSIntractable Pain ... ... ... 2 6 2A n a e s t h e s i a a n d A n a l g e s i a i n D e n t i s t r y ... ... 2 9 3

MAY

E D I T O R I A LPulmonary oxygen toxicity 325

O R I G I N A LThe toxicity of sodium nitroprusside ... ... 327

D. G. McDowall, N. P. Keaney, J. M. Turner,J. R. Lane and Y. Okuda

Tracheal smooth muscle relaxant effect of keta-mine ... ... ... ... ... ... 33 JP. M. Lundy, C. W. Gowdey and E. H.Colhoun

The effect of change in cardiac output on intra-pulmonary shunting ... ... ... ... 337G. Smith, F. W. Cheney, jr. and P. M. Winter

Blood viscosity during anaesthesia with halothane,cyclopropane, thiopentone and ketamine ... 343F. Magora, M. London, D. Eimerl and H. B.Aronson

C L I N I C A LAcid-base changes in cerebrospinal fluid and

blood, and blood volume changes following pro-longed hyperventilation in man ... ... ... 348M. Stig Christensen

Arterial oxygen tension during apnoea in partu-rient women 358Girvice W. Archer, jr. and Gertie F. Marx

Acupuncture analgesia: report of 100 experiments 361Felix Mann

A sequential study of intravenous analgesic treat-ment during labour 365J. Moore and H. G. Ball

Postoperative vomiting after paediatric adeno-tonsillectomy: a survey of incidence followingdiffering pre- and postoperative drugs ... ... 373B. L. Smith and Margaret L. M. Manford

Preliminary experience with a circuit to increasethe airways pressure in adults breathing spon-taneously ... ... ... ... ... ... 379P. T. Walling and T. M. Savege

Pentazocine and diazepam analgesia for minorgynaecological operations ... 385A. Schoenfeld, J. A. Goldman and E. Levy

CASE REPORTSSickle-cell trait: a report of a postoperative

neurological complication ... ... ... 387F. Y. Dalai, G. B. Schmidt, E. J. Bennett andS. Roanamurthy

Lithium: an anaesthetic risk 389Gwyneth Jephcott and R. J. Kerry

BOOK REVIEWModem Hospital Hypnosis

JUNE

EDITORIAL: A painless revolution

386

391

ORIGINALComparison of arrhythmic doses of adrenaline,

metaraminol, ephedrine and phenylephrineduring isoflurane and halothane anaesthesia indogs 392W. K. Tucker, A. D. Rackstein and E. S.Munson

Interactions of beta-receptor blockade and Pco,levels in the anaesthetized dog 397P. Fo'e'x and C. Prys-Roberts

Further observations on depolarizing neuromus-cular block: the so-called phase II block ... 405Anibal Galindo and R. Kennedy

C L I N I C A LDigital vasodilatation: a sign of anaesthesia ... 414

M. JohnstoneLumbar epidural block and the breech presenta-

tion 420P. Bowen-Simpkins and I. L. C. Fergusson

On the availability of oxygen to the body duringcardiopulmonary bypass in man 425E. A. Harris, Eve R. Seelye and B. G. Barratt-Boyes

A new ventilator: a combined minute volumedivider and humidifier 432A. W. Grogono

Plasma protein binding of bupivacaine and itsinteraction with other drugs in man 435M. M. Ghoneim and H. Pandya

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Vlll CONTENTS

The respiratory effects of diazepam supplementa-tion of spinal anaesthesia in elderly males ... 439C. Pearce

Prediction of arterial carbon dioxide tensionusing a circle system without carbon dioxideabsorption 442E. J. Scholfield and N. E. Williams

Diazepam as an adjunct in propanidid anaes-thesia for abortion 446M. A. K. Mattila, M. Rajpar and P. Pystynen

A comparison of lorazepam and diazepam as oralpremedicants for surgery under regional anaes-thesia 449J. A. O. Magbagbeola

Plasma volume during surgery in unsupplementedglucocorticoid-treated patients 452H. Kehlet, A. Engquist and J. Greibe

Anaesthesia for open heart surgery in the calf 455E. L. Gerring and Susan C. Scarth

Endotracheal tube resistances 461J. A. Lack

CASE REPORTAccidental intra-arterial injection of drugs: a

hazard of arterial cannulation 463J. M. Evans, I. P. Lotto and W. S. Ng

CORRESPONDENCEAwake intubation with neuroleptanalgesia in a

patient with severe respiratory obstruction ... 413Redesigned Forrester spray 413Thrombosis following diazepam 413

BOOK REVIEWSAnaesthetic Management of Endocrine Disease 431Anesthetic Uptake and Action 460

JULY

EDITORIAL: New problems for old in the res-piratory system 467

ORIGINALEffect of nitrous oxide on the anaesthetic require-

ment of enflurane 468G. Torn, G. Damia and M. L. Fabiani

The cardiovascular effects of ergometrine in theexperimental animal in vivo and in vitro ... 473M. R. Wassef, H. Lai and Barbara J. Pleuvry

CLINICALFunctional residual capacity during anaesthesia.

I : Methodology 479A. M. Hewlett, G. H. Hulands, J. F. Nunnand K. B. Minty

Functional residual capacity during anaesthesia.I I : Spontaneous respiration ... ... ... 486A. M. Hewlett, G. H. Hulands, J. F. Ntmnand J. R. Heath

Functional residual capacity during anaesthesia.I l l : Artificial ventilation ... ... ... 495A. M. Hewlett, G. H. Hulands, J. F. Nunnand J. S. Milledge

Lower Limb reflex changes in segmental epiduralanalgesia 504P. R. Bromage

Studies of drugs given before anaesthesia. XXIII:Metoclopramide ... ... ... ... ... 509J. W. Dundee, R. S. J. Clarke and P. J. Howard

Studies of drugs given before anaesthesia. XXIV:Metoclopramide with morphine and pethi-dinc 514R. A. E. Atsaj, R. S. J. Clarke, J. W. Dundeeand I. O. Samuel

The incidence and causes of postoperative jaun-dice 520Christine Evans, Mary Evans and A. V. Pollock

A comparison of apomorphine and stomach tubesfor emptying the stomach before general anaes-thesia in obstetrics ... ... ... ... 526J. D. Holdstuorth, Ruth M. B. Furness andR. Gwynne Roulston

Bupivacaine carbonate and bupivacaine hydro-chloride: a comparison of blood concentrationsduring epidural blockade for vaginal surgery 530T. N. Appleyard, Anne Witt, R. E. Atkinsonand A. D. G. Nicholas

APPARATUSSome observations on nitrous oxide cylinders

during emptying 534P. L. Jones

CASE REPORTSParaplegia following coeliac plexus block with

phenol 539E. J. Galizia and S. K. Lahiri

Survival after pulmonary haemorrhage in idiopa-thic respiratory distress syndrome of thenewborn ... ... ... ... ... ... 541A. Entress, K. Kyriakou and A. Cole

CORRESPONDENCEAnaesthesia in a patient with previous malignant

hyperpyrexia ... ... ... 519A lead tooth-bridge 543Respiratory mass spectrometer users' group ... 543Multiple exposure to halothane ... ... ... 543Interpretation of drug binding changes in relation

to protein concentration ... ... ... 545Ketamine and eclampsia ... ... ... ... 546

BOOK REVIEWSCerebrovascular Disease ... ... ... ... 503Anaesthesia and Resuscitation: a Manual for

Medical Students 503

AUGUST

EDITORIAL: Preoperative assessment for anaes-thesia 547

THE INFLUENCE OF DISEASE ONANAESTHESIA

Respiratory aspects of the preoperative examina-tion 549W. G. Anderson

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CONTENTS a

Cardiological aspects of the preoperative examina-tion 555P. R. Fleming

The preoperative chest X-ray ... ... ... 558/. H. Kerr

Biochemical screening tests for the anaesthetist ... 564L. G. Whitby

The incidence of medical disease in surgicalpatients ... ... ... ... ... ... 570K. Kyei-Mensah and J. A. Thornton

Anaesthesia and the hypertensive patient ... 575P. Foex and C. Prys-Roberts

Anaemia and anaesthesia 589/. D. S. Gillies

Neuromuscular disease and anaesthesia 603P. R. Ellis

Drug interactions in anaesthesia ... ... ... 613A. W. Grogono

CASE REPORTAcute adrenal insufficiency during surgery

A. A. Salam and D. M. Davies619

ANAESTHESIA AND MEDICAL DISORDERSSelected references ... ... ... ... ... 623

J. A. Thornton

CORRESPONDENCEPentazocine and intraocular pressure in paediatrics 627The inadvertent continuous spinal continued ... 628Non-kink catheter mount 628A method of artificial ventilation while using

the fiberoptic bronchoscope 628

SEPTEMBER

EDITORIAL: Crisis 629

ORIGINALEffect of acute hypovolaemia on lignocaine

absorption and cardiovascular response follow-ing epidural block in dogs 631K-I. Morikawa, J. J. Bonica, G. T. Tuckerand T. M. Murphy

The effect of ketamine on transmembrane poten-tials of Purkinje' fibres of the pig heart ... 636J. T. Hamilton and J. S. Bryson

Inhalation anaesthetics and their interaction invitro with glutamate dehydrogenase and otherenzymes ... ... ... ... ... ... 643A. Brammall, D. J. Beard and G. H. Hulands

Effects of halothane on DNA synthesis andmitosis in root tip meristems of vicia faba ... 653C. J. Grant, J. N. Powell, and Sheila G.Radford

CLINICALInitial studies in man with a new myoneural

blocking agent (ORG.6368) 658W. L. M. Band

A non-invasive technique of comparing myo-cardial performance following epidural block-ade and vasopressor therapy ... ... ... 662A. L. Forrest, J. I. M. Latuson and P. E.Otton

Residual nerve block following intravenousregional anaesthesia 668C. J. Evans, J. A. Detoar, R. N. Boyes andD. B. Scott

Cerebral blood flow and metabolism duringhypotension induced with sodium nitroprusside 671D. P. G. Griffiths, B. H. Cummins, R. Green-baum, H. B. Griffith, G. E. Staddon, D. G.Wilkms and J. S. M. Zorab

Some effects of maintaining pulmonary nitro-genation during anaesthesia ... ... ... 680J. A. W. Wildsmith and A. H. B. Masson

A comparison of Althesin and methohexitone inpaediatric anaesthesia ... ... ... ... 685P. J. Keep and Margaret L. M. Manford

An assessment of Althesin for the induction ofanaesthesia in cardiac surgical patients: a com-parison with thiopentone ... 687J. N. Broadley and P. A. Taylor

APPARATUSA new blood warmer

D. M. Jackson

OCTOBER

EDITORIAL: Local anaesthesia ...

692

CASE REPORTSBronchial rupture associated with flail chest

treated by external traction ... ... ... 697B. L. Duffy and J. W. Kyle

Ketamine in the management of a case of lym-phosarcoma cutis ... ... 699R. W. Fynn

Myasthenic response to muscle relaxants in vonRecklinghausen's disease ... ... ... 701Anis Baraka

CORRESPONDENCEThe strange case of the (inadvertent) continuous

spinal ... ... 661Increased toxicity of Althesin in newborn animals 704Bacteriological filters for strain gauges ... ... 704Malignant hyperpyrexia caused by trimeprazine 705

... 707

ORIGINALSome effects of enflurane anaesthesia on biogenic

monoamines in the brain and plasma of rats 708P. H. Rosenberg and E. Klinge

Persistent electroencephalographic alterations fol-lowing administration of some volatile anaes-thetics 714Eva M. Kavan, R. M. fulien and J. L. Lucero

Blood viscosity and open heart surgery ... ... 722H. B. Aronson, S. Cotev, F. Magora, J. B.Barman and G. Merin

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CONTENTS

t.

Drug metabolizing ability in operating theatrepersonnel ... ... ... ... 726Margaret Wood, K. CTMaUey and I. H.Stevenson

The effect of methohexitone on myocardial bloodflow and oxygen consumption in the dog ... 729

C. McMillan, D. M. Brown, G. Smith andP. Vance

Mitogen-induced lymphocyte transformation aftergeneral anaesthesia ... ... ... ... 733J. Kanto, M. Vapaavuori and M. K. Viljanen

The effect of ventilation system design on aircontamination with halothanc in operatingtheatres 736D. R. Langley and A. Steward

When does blood haemolyse? 742C. Chalmers and W. J. Russell

CLINICALEpidural analgesia for the surgical induction of

labour ... ... ... ... ... ... 747N. G. Caseby

Pulmonary complications after 154 trans-thoracicoperations requiring more than 8 hoursanaesthesia ... ... ... 752Julie Knudsen and Henning Ruben

Further observations on the effects of generalanaesthesia on intraocular pressure in man:halothane in nitrous oxide and oxygen ... 756M. H. Al-Abrak and J. R. Samuel

Cardiac rhythm in dental anaesthesia: a compari-son of five anaesthetic techniques ... ... 760W. Ryder and D. Townsend

Facial vasomotor behaviour ... ... ... 765M. Johnstone

Arrhythmia and oral surgery: induction of anaes-thesia with Althesin 770J. P. Alexander

Clinical anaesthesia and the multiple-gauzecondenser-humidifier ... ... 773C. A. Shanks

The effects of methylphenidate on postoperativepain and vasoconsmction ... ... ... 778M. Johnstone

GENERAL INTERESTInformation retrieval systems: a guide 784

D. M. Winterburn

CASE REPORTSAtropine toxiciry in a neonate ... ... ... 793

J. S. GiUick

Severe metabolic acidosis following hypotensioninduced with sodium nitroprusside 795W. R. MacRae and Mary Owen

PROCEEDINGS OF THE ANAESTHETICRESEARCH SOCIETY: Sheffield Meeting,July 6, 1974 798

CORRESPONDENCEIncidental hypothermia during surgery for peri-

pheral vascular disease ... 713

BOOK REVIEWSIntensive Care 783Advances in Neurosurgery ... 792

NOVEMBER

ORIGINALThe effects of sodium nitroprusside on myo-

cardial contractility and haemodynamics ... 807A. P. Adams, T. N. S. Clarke, J. Edmonds-Seal, P. Foex, C. Prys-Roberts and J. G.Roberts

Release of thyroxine from the liver during anaes-thesia and surgery ... ... 818W. A. Harland, P. W. Honon R. Strong, B.Fitzgerald, J. R. Richards and K. B. Holloway

Changes in canine myocardial blood flow andoxygen consumption in response to halothane 821G. Smith, J. P. Vance, D. M. Brown and J. C.McMillan

CLINICALThe long-term safety of methoxyflurane analgesia

during labour ... ... 827M. Rosen, A. W. Asscher, M. S. F. Mc-Lachlan and L. A. Williams

Feed-back monitoring in anaesthesia. I l l : Thecontrol of halothane administration by respira-tory patterns ... ... ... 829P. Suppan

Bupivacaine 0.125% in epidural block analgesiaduring childbirth: clinical evaluation ... ... 838G. Vanderick, K. Geermckx, A. L. van Steen-berge and E. de Muylder

Ionized calcium in acidosis: differential effect ofhypercapnic and lactic acidosis 842H. Schaer and U. Bachmann

The effects of cuffed endotracheal tubes on thetracheal wall 849D. B. Mathias and J. R. Wedley

The effect of nitrous oxide and halothane uponthe intracranial pressure in hypocapnic patientswith intracranial disorders ... ... ... 853Bent B. Misfeldt, P. Balslev Jorgtnsen and M.Ruhoj

Humidification and loss of body heat duringanaesthesia. I : Quantification and correlationin the dog 859C. A. Shanks

Humidification and loss of body heat duringanaesthesia. I I : Effects in surgical patients ... 863C. A. Shanks

Chances in visual reaction time following cere-bral angiography 867L. J. Dunkin, J. D. WMtby, S. G. MorreUand T. Blogg

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CONTENTS XI

Adrenocortical response to major surgery andanaesthesia in elderly patients 873

D. J. Botoen and Dorothy J. Richardson

A clinical trial of RoS-4200 (Flunitrazepam) usedto supplement spinal anaesthesia in elderlypatients 877C. Pearce

Althesin in outpatient dental anaesthesia ... 881W. N. RoUason, K. Fidler and J. M. Hough

APPARATUSAn assessment of three electronic respirometers 885

C. M. Conway, J. M. Leigh, T. D. Preston,F. J. M. Walters and D. A. Webb

CASE REPORTSPost-traumatic respiratory distress due to endo-

toxinaemia and intravascular coagulation ... 892J. C. Stoddart and E. N. Wardle

Anaesthetic management of "prune belly"syndrome 897A. Karamanian, R. Kravath, H. Nagashimaand H. H. Gentsch

CORRESPONDENCEPlasma levels of diazepam after oral and intra-

muscular administration 817Mechanical stability of serum cholinesterase ... 837A device for maintaining anaesthesia during

fibreoptic bronchoscopy ... 900

DECEMBER

EDITORIAL: Acknowledgement ... ... 901

ORIGINALIndirect estimation of safety margin in neuro-

muscular transmission 902Yoshie Yamamura, Mitcako Kawamata andMasao Fujita

Relationship between suxamethonium apnoea,serum cholinesterase activity and inhibitornumbers 908J. King and Dorothy Griffin

Comparison of the effects of Althesin and barbi-turates on the neocortex and hippocampus incats 912Y. Kayama

The mod: of action of promethazine in poten-tiating narcotic drugs 918M. Keeri-Szantb

CLINICALArterial oxygen tension during laparoscopy with

nitrous oxide in the spontaneously breathingpatient 925/ . M. Corall, K. Knights, D. Potter and L.Strunin

Immediate changes in plasma potassium, sodiumand chloride induced by intravenous inductionagents 929/. M. Bait and J. W. Dundee

Effects of bitemporal electrical stimulation onthe duration of suxamethonium apnoea in man 934H. S. Subrahmanyam

Bupivacaine 0.125% in epidural block analgesiaduring childbirth: maternal and foetal plasmaconcentrations ... ... ... 937K. Geerinckx, G. Vanderick, A. L. Van Steen-berge, R. Bouche and E. De Muylder

Metabolic response to anaesthesia and upperabdominal surgery in Nigerians: changes inplasma cortisol, insulin and blood sugar ... 942J. A. O. Magbagbeola and B. Kwaku Adadevoh

Anaesthesia for cardioversion: thiopentone withand without atropine premedication 947Riitta Orko

Anaesthesia for emergency coronary arterysurgery . . . . . . ... . . . 953J. F. VUjoen, F. G. Estafanous and K. S. Kim

Skills related to driving after intravenous diaze-pam, flunitrazepam or droperidol 961K. Kontila and M. Linrwila

A method of ventilation with entonox duringbronchoscopy .. . . . . . . . 970P. J. Keep

CORRESPONDENCEToxicity of sodium nitroprusside ... ... 952Dangerous fault in disposable connector for

orotracheal tube ... ... ... 952

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EDITORIAL EXECUTIVE COMMITTEEEditor of General Issues

A. A. SPENCE. Senior Lecturer, University Department of Anaesthesia {Western In-firmary), Glasgow

Editor of Postgraduate Educational Issues•R. A. MILLAR, Professor of Anaesthesia, University Department of Anaesthesia, Glasgow

Royal InfirmaryAssistant Editors

W. G. ANDERSON, University Department of Anaesthesia {Royal Infirmary), GlasgowW. FITCH, Institute of Neurological Sciences, Southern General Hospital, GlasgowG. SMITH, University Department of Anaesthesia {Western Infirmary), Glasgow

Consultant EditorsG. H BOSH, Consultant Anaesthetist, Alder Hey Children's Hospital, LiverpoolC. M. CONWAY, Consultant Anaesthetist, Westminster Hospital, LondonE. A. COOPER, Professor of Anaesthesia, University of Newcastle upon Tyne; Honorary

Consultant Anaesthetist, Newcastle University Hospitals•J. W. DUNDEE, Professor of Anaesthesia, Queen's University of Belfast*T. CECIL GRAY, Professor of Anaesthesia, Dean of the Medical School, University of

Liverpool*A. R. HUNTER (Hon. Treasurer), Reader in Anaesthesia, University of Manchester*D. G MCDOWALL, Professor of Anaesthesia, University of Leeds*W. W. MUSHIN, CB.E., Professor of Anaesthetics, Welsh National School of Medicine* J. F. NUNN, Head of Division of Anaesthesia, Clinical Research Centre, Harrow; Honorary

Consultant Anaesthetist, Northvnck Park HospitalJ. B. OWEN-THOMAS, Senior Lecturer in Paediatric Respiratory Studies, University of

Liverpool•J. P. PAYNE, British Oxygen Research Professor of Anaesthetics, Royal College of Surgeons

of England•J. G. ROBSON, Professor of Anaesthetics, University of London, Royal Postgraduate

Medical School*D. B. SCOTT, Consultant Anaesthetist, Royal Infirmary, Edinburgh

By Constitution the maximum continuous period that may be served on the Editorial ExecutiveCommittee is 5 years. Retired members are eligible for re-election after an interval.

•In addition to those individuals on the EDITORIAL EXECUTIVE COMMITTEE whose names are markedwith an asterisk, the following are members of the BOARD OF MANAGEMENT AND PROPRIETORS:

A. CRAMPTON SMITH, Nuffield Professor of Anaesthetics, Oxford UniversityJ. E. RIDING, Consultant Anaesthetist, United Liverpool Hospitals; Demonstrator in the

Department of Anaesthesia, University of LiverpoolW. D. WYLIE, Consultant Anaesthetist, St Thomas's Hospital, London

Papers for publication and all editorial communications should be addressed to theEditor, University of Glasgow, Department of Anaesthesia (Western Infirmary),4 Lilybank Gardens, Glasgow G12 8RZ; business communications to the publishers:JOHN SHERRATT & SON LTD.. Park Road, Altrincham, Cheshire WA14 5QQ.

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Dow



INDEXVOLUME 46, 1974

(Compiled by R. K. Parikh)

/i.R5=Anaesthetic Research Society PapersC =CorrespoadenceE =EditorialR =Book Review

Abdominal distension, anaesthetic management.DATTA, P. K., et al 311

ABODLEISH, E. Inadvertent continuous spinal (C)628Acid aspiration syndrome, response to endotracheal

instillation of HCl/Hartmann's solution. DAVIDSON,J. T. ,e ta l 127

Acid-base changes in arterial blood and c.s.f. duringcraniotomy and hyperventilation. CAMPKIN, T. V.,et al 263

Acid-base changes in c.s.f. and blood after prolongedhyperventilation. CHRISTHNSEN, M. S 348

Acidosisafter nitroprusside-induced hypotension. MCRAE,

W. R., et al 795ionized calcium in. SCHAER, H., et al 842

Acknowledgement (£)901Acupuncture analgesia. MANN, F 361ADADEVOH, B. K., see MAGBAGBEOLA, J. A. O.ADAMS, A. P., CLARKE, T. N. S., EDMONDS-SEAL, J.,

Fofix, P., PRYS-ROBERTS, C , and ROBERTS, J. G.The effects of sodium nitroprusside on myocardialcontractility and haemodynamics 807

ADAMS, D. J., see HOLDCROFT, A.Adipose tissue, see Fat.Adrenals, see also Autonomic nervous system

acute insufficiency during surgery. SALAM, A. A.,etal. 619

adrenaline, arrhythmic dose under halothane andisoflurane. TUCKER, W. K., et al 392

adrenocortical response to surgery in aged.BOWEN, D. J., et al 873

biogenic monoamines with enflurane. ROSENBERG,P. H., et al 708

catecholamine concentrations in plasma duringsurgery. KEHLET, H., et al 73

catecholamines in suxamethonium-inducedhyperthermic pigs. LISTER, D., et al (ARS)803

phaeochromocytoma, extradural blockade inmanagement of. COUSINS, M. J., et al 78

plasma cortisol changes after surgery in Nigerians.MAGBAGBEOLA, J. A. O., et al 942

plasma volume during surgery in patients onglucocorticoids. KEHLET, H., et al 452

Age, see also Paediatricsadrenocortical response to surgery in aged.

BOWEN, D. J., et al 873flunitrazepam supplemented spinal block in aged.

PEARCE, C 877AH8165, intubation with. YOUNG, H. S. A., et al.(ARS)317Air intake valve. Fox, D. E. R (C)310Airway closure, in pulmonary oedema and raised left

atrial pressure. JONES, J. G., et al (AR5)321AL-ABRAK, M. H., BRISCOE, C. E., and PAYNE, J. P.

The effects of halothane anaesthesia on oxygenconsumption and respiration in man {AR5)321

SAMUEL, J. R. Further observations on the effectsof G. A. on intraocular pressure in man: halothanein N tO and O, 756

Albumin extravasation in surgery. GROGONO,A. W (ARS)320

Alcohol, measurement with a helium-neon laser.ALOBAIDI, T. A. A., et al (ARS)317

ALEXANDER, J. P. Arrhythmias in oral surgery:induction of anaesthesia with Althesin 770

ALI, M. M., see QKUDA, Y.ALLOTT, P. R., see MAPLESON, W. W.

, see STEWARD, A.ALMEIDA, A. P., see Cox, L. A.ALOBAIDI, T. A. A.. HILL, D. W., and PAYNE, J. P.

The use of helium-neon laser for the in vivomeasurement of breath alcohol (ARS)317

Alpha-adrenergic receptors or blockade, see Auto-nomic nervous system

Alphaxalone, see AlthesinAlthesin, see also I.V. Induction agents

adverse reaction, KESSELL, J., et al (Q209adverse reactions survey. SUTTON, J. A., et al.

(ARS)8O6arrhythmias in oral surgery. ALEXANDER, J. P . . . 770barbiturates and, on neocortex and hippocampus

in cats. KAYAMA, Y 912bronchospasm with. KOUNIS, N. G (C)281cardiac surgery in, compared with thiopentone.

BROADLEY, J. N., et al. 687metabolism of 14C-Alphaxalone, STRUNTN, L.,

et al (ARS)319methohexitone and, in paediatrics. KEEP, P. J.,

et al 685outpatient dentistry in. ROLLASON, W. N., et al.. . 881paediatric outpatient otology in, and thiopentone.

SAARNTVAARA, L 268reaction to i.v. agents. TWEEDIE, D. G., et aL . .(Q244recovery after, compared with thiopentone.

DDBOIS, M., et al (ARS)320toxicity in newborn animals GYERMEK, L (C)704

Anaemia, see BloodAnaesthesia

acupuncture analgesia. MANN, F 361blood viscosity after. MAGORA, F., et al 343DNA synthesis in Chinese hamster fibroblasts.

STURROCK, J. E., et al (ARS)316intracranial and arterial pressures during ter-

mination of. LEECH. P., et al (ARS)3\5mitogen-induced lymphocyte transformation.

KANTO, J., et al 733physical chemistry applied to anaesthetic action.

HALSEY, M. J 172programmed, non-feedback technique. MAPLE-

SON, W. W., et al (ARS)805prolonged, pulmonary complications. KNUSDEN,

J., et al 752requirement of enflurane, effect of N,O on.

TORRI, G., et al 468sign, digital vasodilatation. JOHNSTONE, M 414temperature and pressure changes in experimental

anaesthesia. WHITE, D. C , et al 196

Dow



974 BRITISH JOURNAL OF ANAESTHESIA

Anaesthesia (com.)

thyroxine release from liver. HARLAND, W. A..etal 818

uptake and action. EGER, E. I CR}460Anaesthesia and/for

abdominal distension. DATTA, P. K., et al 311anaemia, GILLIES, I. D. S 589bronchoscopy

removal of foreign bodies in children.BARAKA, A 124

ventilation during fiberoptic bronchoscopy.EDWARDS, E. M., et al (Q628

ventilation with Entonox. KEEP, P. J 970cardioversion. ORKO, R 947coronary artery surgery, emergencies. VILJOEN,

J. F., et al 953drug interactions. GROGOKO, A. W 613E.M.O. system. FARMAN, J. V (i?)216endocrine disease. OYAMA, T (R)431hypertensive patients. Fofix, P., et al 575influence of disease, Symposium Number 8malignant hyperpyrexia, a patient with previous

attack. JUDELMAN, H., et al (C)519medical disorders, selected references. THORN-

TON, J. A 623minor gynaecological operations, pentazocine and

diazepam in. SCHOENFELD, A., et al 385neuromuscular disease. ELLIS, F. R 603open heart surgery in the calf. GERRINO, E. L.,

et alphaeochromocytoma. COUSINS, M. J., et al!<Prune belly" syndrome. KARAMANIAN, A., et al.renal transplantation. LOGAN, D. A., et alrespiratory obstruction, awake intubation under

neuroleptanalgesia. ANAND, J. Sresuscitation. GORDON, R. Auncommon diseases. KATZ, J., et al

Anaesthetic agents, see specific agents and alsoInhalation agents and Intravenous induction agents

cardiac rhythm in dental anaesthesia, RYDER, W.,ct al 760

enzymes in rat kidney, in-vivo effects. WITT, A.,et al (ARS)&04

solubility coefficients. STEWARD, A., et al (C)310vomiting after paediatric adenotonsillectomy.

SMITH, B. L., et al 373Anaesthetic macromolecule interactions. HALSEY, M.

J.,etal (ARS)805Anaesthetic molecules, RUDO, F. G., et al 181Analgesia and analgesics, see Pain relief and specific

agents.ANAND, J. S. Awake intubation with neuroleptanal-

gesia in presence of respiratory obstruction (C)413ANCILLO, P., see ESTEBAN, A.ANDERSON, W. G. Respiratory aspects of preoperative

examination 549Anesthetic uptake and action. EGER, E. I (R)460ANSELL, G. Notes on radiological emergencies (i?)235Apomorphine, stomach tubes compared to, for empty-

ing stomach. HOLDSWORTH, J. D 526Apparatus

air intake valve. Fox, D. E. R (C)310bacterial filters for ventilators. HOLDCROFT, A.,

et al (ARS)3\9bacterial filters forstraingauges.LAOC.J. A.,etal. (C)704blood wanner. JACKSON, D. M 692catheter mount, non-kink. JAMIL, A. K (C)628circle system without CO. absorption, prediction

of PaCO2. SCHOLFTELD, E. J., et al 442circuit for spontaneous positive pressure ventila-

tion in adults. WALLING, P. T., et al 379endotracheal tube resistances. LACK, J. A 461

45578

89769

O413i?)503fl)246

Apparatus (com.)

fibreoptic bronchoscopy, a device for anaesthesia.CORFIELD, H. M. C (Q900

Forrester spray, redesigned. FORRESTER, A. C.. .(C)413helium-neon laser in breath alcohol measurement.

ALOBAIDI, T. A. A., et al (AHS)317humidifier, multiple gauze condenser. SHANKS,

C. A 773intravenous administration sets, paniculate con-

tamination after flushing and filtration.HARRISON, M. J., et al 59

microfilters in blood transfusion. BULEY, R. B.,et al (ARS)319

N,O cylinders, pressure monitoring of. JONES,P. L 534

oxygen electrodes, comparison of blood-gasfactors. BIRD, B. D., et al 249

oxygen failure warning device. RITCHIE, J. R... (C)323resistance in inhalation analgesia during labour

DAVDZS, J. M., et al 136HOGG, M. I. J., et al 149

resistance of Entonox valves. DAVIES, J. M., et al. 145respiratory flowmeter. BOUCHER, R. F (ARS)8Q5respirometer, electronic. Cox, L. A., et al 302respirometers, three electronic. CONWAY, C. M.,

et al 885syringes, infection hazard. BLOGG, C. E., et aL . . 260swivel connectors. HOLDCROFT, A., et al 298tonometer, new, thin film. CHALMERS, C , et al. 253tooth-bridge of lead. FRY, E. N. S (C)543ventilator. GROGONO, A. W 432

AFPLEYARD, T. N. Pentazocine on sheep papillarymuscle in-vitro (ARS)799

WITT, A., ATKINSON, R. E., and NICHOLAS,A. D. G. Bupivacaine carbonate and hydrochloride:comparison of blood concentrations in epidural(extradural) blockade for vaginal surgery 530

ARCHER, G. W. jr, and MARX, G. F. Arterial oxygentensions during apnoea in parturient women 538

ARONSON, H. B., COTEV, S., MAGORA, F., BORMAN,J. B., andMERiN, G. Blood viscosity and open heartsurgery: comparison in systemic and pulmonaryvessels 722

, see MAGORA, F.Arrhythmias, see HeartArteries

arterial oxygen, see Oxygenarterial pressure, see Pressure and Induced

hypotensioncannulation, accidental intra-arterial injection of

drugs. EVANS, J. M., et al 463cannulation, complications of. EVANS, P. J. D.,

et al (ARS)318hypertension and anaesthesia. Foix, P., et al 575

ASEEM, E. S. K., see KESSELL, J.ASSAF, R. A. E., CLARKE, R. S. J., DUNDEE, J. W., and

SAMUEL, I. O. Studies of drugs given beforeanaesthesia. XXIV: Metoclopramide with mor-phine and pethidine 514

ASSCHER, A. W., see ROSEN, M.ASSEM, E. S. K., see KESSELL, J.ATKINSON, R. A., see LEE, J. A.ATKINSON, R. E., see APPLEYARD, T. N.Atropine, cardioversion, anaesthesia for. ORKO, R... 947Atropine toxicity in a neonate. GDLLICK, J. S 793Autonomic nervous system, see also Adrenals

adrenaline, metaraminol, ephedrine, phenyl-ephrine; arrhythmic doses under halothaneand isoflurane. TUCKER, W. K., et al 392

beta-receptor blockade: Pco, level interactions.Fotx, P., et al 397

trichloroethylene and. FoEx, P., et al.. .(ARS)798

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INDEX 975

Autonomic nervous system (cont.)digital vasodilatation. JOHNSTONE, M 414facial vasomotor behaviour. JOHNSTONE, M 765propranolol, c.v. interactions with halothane and

hypoxaemia. ROBERTS, J. G., et al (ARS)321vasopressors with extradural block, myocaidial

performance. FORREST, A. L., et al 662Automated anaesthesia, feed-back monitoring. SUP-

PAN, P 829

B

BACHMANN, U., see SCHAER, H.Bacterial filters for ventilators. HOLDCROFT, A., et al.

(AR 5)319BAILENSON, G. 77K relaxed patient: a manual of

sedative techniques (R) 53BAIRD, W. L. M. Initial studies in man with a new

myoneural blocking agent (ORG.6368) 658BALI, I. M., and DUNDEE, J. W. Immediate changes in

plasma potassium, sodium, and chloride induced byl.v. induction agents 929

The source of potassium (ARS)803BALL, H. G., see MOORE, J.BARAKA, A. Bronchoscopic removal of inhaled foreign

bodies in children 124Myasthenic response to relaxants in von

Recklinghausen's disease 701Barbiturates and Althesin on neocortex and hippo-

campus in cats. KAYAMA, Y 912Barbiturates, hexobarbitone—brain distribution, liver

metabolism in genotype strains of mice. HALEVY, S.,et al 43

BARKER, J. N,O and intracranial pressure (C)116, see LEECH, P.

BARKER, R. G., see CAMPKIN, T. V.BARRATT-BOYES, B. G., see HARRIS, E. A.BAULD, H. W., GIBSON, P. F., JEBSON, P. J., and

BROWN, S. S. Aetiology of prolonged apnoea aftersuxamethonium 273

BEARD, D. J., see BRAMMALL, A.BENNETT, E. J., see DALAL, F. Y.BENNETT, M. J., see CLARKE, T. N. S.

, see Fofix, P., see ROBERTS, J. G.

Benzoctamine. MCCAUGHEY, W., et al (C)189Beta-adrenergic receptor activity and blockade, see

Autonomic nervous systemBiochemical screening tests. WHTTBY, L. G 564Biogenic monoamines, enflurane effects in rat brain

and plasma. ROSENBERG, P. H., et al 708Biomedical progress and human values; challenge of life.

Roche anniversary symposium (i?) 28Biostatistics in pharmacology. DELAUNOIS, A. L (i?)245BIRD, B. D., WILLIAMS, JV, and WHITWAM, J. G. The

blood gas factor: a comparison of three differentoxygen electrodes 249

, see CHALMERS, C.BIRO, G., see CLARKE, T. N. S.Bitemporal electrical stimulation, see Electroconvul-

sive therapyBLOGG, C. E., RAMSAY, M. A. E., and JARVIS, J. D.

Infection hazard from syringes 260BLOGG, T., see DUNKIN, L. J.Blood

acid-base changes after prolonged hyperventila-tion. CHRISTENSEN, M. S 348

acid-base changes during craniotomy and hyper-ventilation. CAMPKIN, T. V., et al 263

anaemia and anaesthesia. GILLIES, I. D. S 589anaemia—haemodilutional, compensatory mech-

anisms. CLARKE, T. N. S., et al (ARS)199

Blood (cont.)arterial gas tensions in assessment of venous

admixture. OWEN-THOMAS, J. B., et al.. (ARS)8O2biogenic monoamines with enflurane. ROSENBERG,

P. H., et al 708bupivacaine concentrations in extradural block

APPLEYARD, T. N., et al 530GEERINCKX, K., et al 937

endotoxinaemia and intravascular coagulation inpost-traumatic respiratory distress. STODDART,J. C , et al 892

fibrinogen, anaesthesia and, MAGORA, F., et al. . . 343gases, see Respirationglucose, preoperative hypoglycaemia in children.

THOMAS, D. K. M 66haematocrit, anaesthesia and. MAGORA, F., et al. 343haemolysis and temperature. CHALMERS, C , et al. 742hypovolaemia and extradural block. MORIKAWA,

K. I., et al 631ionized calcium in hypercapnic and lactic acidosis.

SCHAER, H., et al 842lymphocyte transformation, mitogen—induced

after general anaesthesia. KANTO, J., et al 733plasma catecholamine concentrations during

surgery. KEHLET, H., et al 73plasma chloride after i.v. induction agents. BALI,

I. M., et al 929plasma cortisol, insulin and blood sugar changes

after surgery in Nigerians. MAGBAGBEOLA,J. A. O., et al 942

plasma diazepam levels after oral and i.m. routes.KANTO, J (C)817

plasma potassium and sodium after i.v. inductionagents. BALI, I. M., et al 929

plasma protein binding of bupivacaine. GHONEIM,M. M., et al 435

plasma protein concentrations and tubocurarinerequirements in newborn. VIVORI, E., et al. . . 93

plasma volume in patients oncorticoids. KEHLET,H.,etal 452

potassium increase, source of. BALI, I. M.,et al (ARS)803

protein concentration and drug binding. GRETCH,M., etal (C)545

proteins, anaesthesia and. MAGORA, F., et al. . . 343serum cholinesterase, mechanical stability. VELLA,

F (C)837serum cholinesterase numbers in suxamethonium

apnoea. KrNG, J., et al 908serum uric acid levels after methoxyflurane.

HAMILTON, W. F. D., et al 54tonometer—thin film. CHALMERS, C , et al 253transfusion, microfilters in. BULEY, R. B., et al.

(ARS)319viscosity and anaesthesia. MAGORA, F., et al 343viscosity and open heart surgery. ARONSON, H. B.

et al 722volume changes after prolonged hyperventilation.

CHRISTENSEN, M. S 348warmer. JACKSON, D. M 692

Blood-gas factor, comparison of three Oj electrodes.BIRD, B. D., et al 249

BLUNDELL, M. D., see MERRIFIELD, A. J.Body air cavities, transfer of N,O into. MUNSON, E. S. 202BONICA, J. J. Obstetric anaesthesia and analgesia • • . .(J?)148

, see MORIKAWA, K-I.Book Reviews

Advances in neurosurgery—1. SCHURMANN, K., et al. 792Anaesthesia and resuscitation: a manual for medical

students. GORDON, R. A 503Anaesthesia and the E.M.O. system. FARMAN, J. V. 216

Dow




Book Reviews (cont.)Anaesthesia and uncommon diseases: Pathophysiologic

and clinical correlations. KATZ, J., et al 246Anaesthetic management of endocrine disease. OYAMA,

T 431Anesthetic uptake and action. EGER, E. 1 460Biostatistics in pharmacology. DELAUNOIS, A. L 245Cerebrovascular disease. MEYER, J. S., et al 503Challenge of life: Biomedical progress and human

values. Roche anniversary symposium 28Drugs in anaesthetic practice. WOOD-SMITH, F. G.,

et al 201Extrasystoles and allied arrythndas. SCHERF, D.,

et af. 104Intensive care. WAHLIN, A., et al 783Modern hospital hypnosis: Especially for anaesthetists.

SCOTT, D. L 386Muscle relaxants (Major problems in anaesthesia.

Vol. 1). FELDMAN, S. A 167Neurophysiological background for anaesthesia.

BRAZIER, M. 246Notes on radiological emergencies. ANSELL, G 235Obstetric analgesia and anaesthesia. BONICA, J. J. 148Pain relief in labour. More, D. D 201Pathological and pharmacological considerations in

anesthesiology. BRECHNER, V. L 245Penthrane in clinical anaesthesiology. HAIGH, B 65Relaxed patient: a manual of sedative techniques.

BAILENSON, G 53Synopsis of anaesthesia. T..EE, J. A., et al 28

BORMAN, J. B., see ARONSON, H. B.BOUCHE, R., see GEERINCKX, K.BOUCHER, R. F. A novel respiratory flowmeter.. (ARS)805BOYES, R. N., see EVANS, C. J.BOWEN, D. J.j and RICHARDSON, D. J. Adrenocortical

response to surgery and G.A. in aged 873BOWEN-SIMPKINS, P., and FERGUSSON, I. L. C.

Lumbar epidural (extradural) block and the breechpresentation 420

Brainsee also Electroencephalography and Nervous

systemAlthesin and barbiturates on neocortex and

hippocampus. KAYAMA, Y 912angiography and visual reaction times. DUNKIN,

L. J., et al 867biogenic monoamines after enflurane. ROSENBERG,

P. H., et al 708blood flow and N,O. BARKER, J (C)116blood flow during nitroprusside induced hypo-

tension. GRIFFITHS, D. P. G., et al 671Cerebrovascular disease. MEYER, J. S.,etal (i?)503circulation, CO, responsiveness in hypotension

with halothane. OKUDA, Y., et al (ARS)316disposition of barbiturates in genotype strains of

mice. HALEVY, S., et al 43intracranial pressure after nitrous oxide and

halothane. MISFELDT, B. B., et al 853intracranial pressure and N,O. BARKER, J (C)116metabolism during nitroprusside induced hypo-

tension. GRIFFITHS, D. P. G., et al 671BRAMMAIX, A., BEARD, D. J., and HULANDS, G. H.

Inhalation anaesthetics and their interactions withglutamate-dehydrogenase and other enzymes invitro 643

BRAZIER, M. TTU neurophysiological background foranaesthesia (i?)246

BRECHNER, V. L. Pathological and pharmacologicalconsiderations in anesthesiology (R)245

BRISCOE, C. E., see AL-ABRAK, M. H.

BROADFIELD, J. B., see CORALL, I. M.BROADLEY, J. N., and TAYLOR, P. A. Althesin for

induction in cardiac surgery, compared withthiopentone 687

BROCK, M., see SCHURMANN, K.BROMAGE, P. R. Lower limb reflex changes in seg-

mental epidural (extradural) analgesia 504Bronchi

bronchoscopya device for anaesthesia in fibreoptic bronch-

oscopy. CORFTELD, H. M. C (C)900IPPV with fiberoptic bronchoscope.

EDWARDS, E. M., et al (Q628removal of foreign bodies in children.

BARAKA, A 124ventilation with Entonox. KEEP, P. J 970

bronchospasm by Althesin and pancuronium.KOUNIS, N. G (C)281

endobronchial anaesthesia, oxygenation in. KERR,J. H., et al 84

rupture with flail chest, treated with traction.DUFFY, B. L., et al 697

BROWN, D. M., see MCMILLAN, J. C., see SMITH, G.

BROWN, F. F., see HALSEY, M. J.BROWN, S. S., see BAULD, H. W.BRYSON, J. S., see HAMILTON, J. T.BULKY, R. B., and LUMLEY, J. A preliminary study of

micro-filters, role in blood transfusion (ARS)319Bupivacaine

0.125% in extradural analgesia for labourVANDERICK, G., et al 838maternal and foetal plasma concentrations.

GEERINCKX, K., et al 937carbonate and hydrochloride, comparison of

blood concentrations in extradural blocks.APPLEYARD, T. N., et al 530

protein binding and interaction with drugs.GHONHEIM, M. M., et al 435

BUSH, G. H., see VIVORI, E.

Calcium, ionized, in acidosis. SCHAER, H., et al 842CAMPBELL, D., see THOMSON, D. F.CAMPKIN, T. V., BARKER, R. G., PABARI, M., and

GROVE, L. H. Acid-base changes in arterial bloodand cerebrospinal fluid during craniotomy andhyperventilation 263

Carbon dioxide, see also Respirationbeta-receptor blockade and Pco, level interactions

in anaesthesia. Fofix, P., et al 397cerebral circulation responsiveness in hypotension

with halothane, OKUDA, Y., et al (ARS)316prediction of Paco, using circle system without

CO, absorption. SCHOLFIELD, E. J., et al 442Cardiac surgery, Althesin and thiopentone. BROADLEY,

J. N., ct al 687Cardiovascular, see CirculationCAROLI, G., see Rucci, F. S.CASALE, F. F., and PATEL, S. M. TWO case reports of

Elapid snake bite 162CASEBY, N. G. Epidural (extradural) analgesia for the

surgical induction of labour 747Catecholamines, see AdrenalsCatheter mount, non-kink, JAMIL, A. K (C)628Central venous pressure during laparoscopy. KELMAN,

G. R-, et al (ARS)801CERDA, E., see ESTEBAN, A.

Dow



INDEX 977

Cerebrospinal fluidacid-base changes after prolonged hyperventila-

tion. CHRISTENSEN, M. S 348acid-base changes during craniotomy and hyper-

ventilation. CAMPKIN, T. V., et al 263Cerebrovascular disease. MBYER, J. S., et al (i?)503CHALMERS, C , BIRD, B. D., and WHITWAM, J. G.

Evaluation of a new thin-film tonometer 253, RUSSELL, W. J. When does blood haemolyse?

A temperature study 742Chemistry, physical

applied to anaesthetic action. HALSEY, M. J. . . 172in anaesthesia (£)171Symposium Number 3

CHENEY, F. W., jr, see SMITH, G.Chest injury, bronchial rupture with flail chest,

treated by traction. DUFFY, B. L., et al 697CHRISTENSEN, M. S. Acid-base changes in c.s.f. and

blood, and blood volume changes following pro-longed hyperventilation in man 348

Circle system without CO, absorption, prediction ofPa0o,- SCHOLFIELD, E. J., et al 442

Circulationsee also Heart; for organ circulation, see under

related organ, e.g. renal circulation, see kidneybeta-receptor blockade and Pco, level interactions

in anaesthesia. Fofix, P., et al 397ergometrine, cardiovascular effects. WASSEF,

M. R., et al 473extradural analgesia in labour, c.v. changes.

CORALL, I. M., et al (ARS)80\extradural block and hypovolaemia. MORIKAWA,

K-I., etal 631haemodilutional anaemia, compensatory

mechanisms. CLARKE, T. N. S., et al . . . .(ARS)799haemodynamic effects of diazepam. JENKINSON,

J. L... et al 294haemodynamics and pulmonary gas exchange in

halothane induced hypotension. PRYS-ROBERTS,C . et al 105

hypertensive patients and anaesthesia. Fofix, P.,et al 575

hypovolaemia, c.v. responses in extradural block.MORIKAWA, K-I., et al 631

induced hypotension, see Induced hypotensioninferior vena caval occlusion. MALATINSKY, J.,

et al 165interactions of halothane, propranolol and hypo-

xaemia. ROBERTS, J. G., et al (ARS)321nitroprusside, see

ADAMS, A. P., et al 807JACK, R. D (C)952MCDOWALL, D. G., et al (C)323; 327MERRIFIELD, A. J (C)324

oxygen availability during cardiopulmonary by-pass. HARRIS, E. A., et al 425

preoperative assessment. FLEMING, P. R 555pulmonary artery catheterization and wedge pres-

sure in intensive therapy. GILBERTSON, A. A.. . 97pulmonary oedema and raised left atrial pressure,

airway closure in. JONES, J. G., etal (ARS)32ltransoesophageal ultrasonic monitoring. TOM-

LDM, P. J., et al (ARS)318CLARIDGE, E., see TOMLIN, P. J.CLARKE, G. M., see SMITH, W. D. A.

, see MAPLESON, W. W.CLARKE, I. M. C , and ELLIS, F. R. Studies of the

therapeutic value of procaine and lignocaine inmalignant hyperpyrcxia (ARS)315

CLARKE, R. S. J., see ASSAF, R. A. E., see DUNDEE, J. W.

CLARKE, R. S. J., see YOUNG, H. S. A.CLARKE, T. N. S., PRYS-ROBERTS, C , BIRO, G.,

FOBS, P., ROBERTS, J. G., and BENNETT, M. J.Compensatory mechanisms in haemodilutionalanaemia (ARS)799

, see ADAMS, A. P., see Fofix, P., see ROBERTS, J. G.

Coeliac plexus block, paraplegia after. GALEIA, E. J.,et al 539

COHN, M. L. Doxapram hydrochloride (C)169COLHOUN, E. H., see LUNDY, P. M.COLE, A., see ENTRESS, A.Complications, see also Toxicity

acute adrenal insufficiency during surgery.SALAM, A. A., et al 619

arterial cannulation of. EVANS, P. J. D., et al. (ARS)318arterial cannulation, accidental injection of drugs.

EVANS, J. M., et al 463diazepam, thrombosis after. PADFIELD, A (CV413endotracheal tube obstruction. POWELL, D. R. (Q252extradural block, continuous spinal in

ABOULEISH, E (C)628CRAWFORD, J. S (Q82; 661DOCTOR, N. H (C)661

faulty disposable connector for orotracheal tube.OSTERUD, A (C)952

infection hazard from syringes. BLOGG, C. E.,et al 260

paraplegia after coeliac plexus block. GALKIA,E. J., et al 539

pulmonary, after prolonged trans-thoracic sur-gery. KNUSDEN, J., et al 752

sickle-cell trait, postoperative neurological.DALAL, F. Y., et al 387

CONWAY, C. M., LEIGH, J. M., PRESTON, T. D.,WALTERS, F. J. M., and WEBB, D. A. Anassessment of three electronic respirometers 885

COPLANS, M. P., see GREEN, R. A.CORALL I. M., KNIGHTS, K., POTTER, D., and

STRUNIN, L. Pa0. during laparoscopy with N,Oand spontaneous breathing 925

BROADFIELD, J. B., NICHOLSON, J., and STRUNIN,L. Cardiovascular changes in extradural analgesiain labour (ARS)801

CORFIELD, H. M. C. A device for anaesthesia in fibre-optic bronchoscopy (C)900

Coronary artery surgery anaesthesia. VILJOEN, J. F.,et al 953

COTEV, S., see ARONSON, H. B.COUSINS, M. J., and RUBIN, R. B. The intraoperative

management of phaeochromocytoma with totalepidural (extradural) sympathetic blockade 78

COWLES, A. L., see STEWARD, A.Cox, L. A., ALMEIDA, A. P., ROBINSON, J. S., and

HORSLEY, J. K. An electronic respirometer 302Craniotomy, see Nervous systemCRAWFORD, J., see LOGAN, D. A.CRAWFORD, J. S. The strange case of (inadvertent)

continuous spinal (C)82; 661Crisis (staffing) (£)629CUMMINS, B. H., see GRIFFITHS, D. P. G.Cyclopropane

blood viscosity after. MAGORA, F., et al 343pulmonary equilibration in infants, role of brown

fat. RACKLOW, H., et al 29

D

DALAL, F. Y., SCHMIDT, G. B., BENNETT, E. J., andRAMAMURTHY, S. Sickle-cell trait: a report of apostoperative neurological complication 387

Dow




DAMIA, G.. see TORRI, G.DARLOW, M., see HOLDCROFT, A.DATTA, P. K., JAIN, P. D., and SHARMA, E>. Anaes-

thetic management of abdominal distension 311DAVIDSON. J. T.. RUBIN, S., EYAL, Z., and POLLIACR,

A. Pulmonary response to endotracheal instillationof HCl/Hartmann's solution in the rabbit 127

DAVIES, D. M-, see SALAM, A. A,DAVIES, J. M., HOGG, M. I. J., and ROSEN, M. Resist-

ance of Entonox valves 145Upper limits of resistance of

apparatus for inhalation analgesia during labour.. . . 136, see HOGG, M. I. J.

DELAUNOIS, A. L. Biostatistics in pharmacology.. ..(i?)245DE MUYLDER, E., see GEERINCKX, K.

, see VANDERICK, G.Dental anaesthesia

Althesin induction and arrhythmias in oralsurgery. ALEXANDER, J. P 770

Althesin in outpatients, ROLLASON, W. N., et al. 881Anaesthesia and analgesia in dentistry. GREEN,

R. A., et al (J?)293cardiac rhythm in. RYDER, W., et al 760haemodynamic effects of diazepam. JENKINSON,

J. L., et al 29427t« relaxed patient: Manual of sedative techniques.

BATLENSON, G (R) 53DHWAR, J. A., see EVANS, C. J.Diazepam

adjunct in propanidid anaesthesia for abortion.MATTTLLA, M. K., et al 446

concentrations in adipose tissue. KANTO, J. H.,etal (Q168

haemodynamic effects, as sedative in oralsurgery. JENKINSON, J. L., et al 294

minor gynaecological operations with pentazocine.SCHOENFELD, A., et aL 385

oral premedicant with local blocks. MAGBAG-BEOLA, J. A. 0 449

pain thresholds. HALL, G. M., et al 50plasma levels after i.m. and oral routes. KANTO,

J (O817respiratory effects with spinal anaesthesia.

PEARCE, C 439skills related to driving. KORTTILA, K., et al 961thrombosis after. PADFTELD, A (C)413

Digital vasodilatation: sign of anaesthesia. JOHN-STONE, M 414

Distribution, see PharmacokineticsDNA synthesis

anaesthesia effects. STURROCK, J. E., et al. • -(ARS)316halothane effects. GRANT, C. J., et al 653

DOCTOR, N. H. Inadvertent continuous spinal (0^6 *Doxapram hydrochloride. COHN, M. L (C)189

DUNDEE, J. W (0)169Droperidol, skills related to driving. KORTTILA, K., et

al 961Drug

binding and blood proteins. GRETCH, M-, et al. •. (C)545Drugs in anaesthetic practice. WOOD-SMITH, F. G.,

etal (R)201interactions in anaesthesia. GROGONO, A. W 613metabolizing ability in theatre personnel. WOOD,

M., et al 726DTJBOIS, M., and GEDDES, I. C. Comparative study of

recovery from short anaesthesia with thiopentone orAlthesin, apparatus used and results {AR5)320

DUCK, F., see TOMLIN, P. J.DUFFY, B. L., and KYLE, J. W. Bronchial rupture with

flail chest, treated by external traction 697

DUNDEE, J. W., CLARKE, R. S. J., and HOWARD, P. J.Studies of drugs given before anaesthesia. XXIII:Metoclopramide 509

, doxapram hydrochloride (C)169, see ASSAF, R. A. E., see BALI, I. M., see YOUNG, H. S. A.

DUNKIN, L. J., WHTTBY, J. D., MORRELL, S. G., andBLOGG, T. Visual reaction times after cerebralangiography 867

E

Editorialsacknowledgement 901crisis (starring) 629jaundice and repeated exposure to halothane . . 1local anaesthesia 707new problems for old in the respiratory system 467painless revolution 391physical chemistry in anaesthesia? 171preoperative assessment 547primary examination 83pulmonary oxygen toxicity 325pursuit of a chimera 247retiral of Dr J. E. Riding 1

EDMONDS-SEAL, J., see ADAMS, A. P.EDWARDS, E. M., and STEER, B. A method of artificial

ventilation while using fiberoptic bronchoscope .. (C)628EGER, E. I. Anesthetic uptake and action (/?)460

, see FRANCE, C. J.EICHORN, O., see MEYER, J. S.EIMERL, D., see MAGORA, F.Electroconvul8ive therapy and suxamethonium apnoea

duration. SUBRAHMANYAM, H. S 934Electroencephalography

Althesin and barbiturates on neocortex andhippocampus in cats. KAYAMA, Y 912

NSO at atmospheric and hyperbaric pressuresSMITH, W. D. A., et al 3

volatile anaesthetics. KAVAN, E. M., et aL 714ELfo, F. J. De, see ESTEBAN, A.ELLIS, F. R. Neuromuscular disease and anaesthesia.. 603

, see CLARKE, I. M. C.E.M.O. Anaesthesia and the E.M.O. system. FARMAN,

J-V (Endobronchial anaesthesia, see BronchiEndocrine disease, Anaesthetic management of endo-

crine disease. OYAMA, T (i?)431Endotracheal, see TracheaEnflurane

anaesthetic requirement with N,O. TORRI, G.,et al. 468

biogenic monoamines in brain and plasma.ROSENBERG, P. H., et al 708

ENGQUIST, A., see KEHLET, H.Entonox, see Nitrous oxide.ENTRESS, A., KYRIAKOU, K., and COLE, A. Survival

after pulmonary haemorrhage in idiopathic RDS ofthe newborn 541

Enzymesanaesthetic agents on rat kidney enzymes. WITT,

A., et al (ARS)804inhalation anaesthetics, in vitro interactions.

BRAMMALL, A., et al 643Ephedrine, see Autonomic nervous systemEpidural block, see Extradural block.Equipment, see ApparatusErgometrine, cardiovascular effects. WASSEF, M. R.,

et al 473ESTAFANOUS, F. G., see VnjOEN, J. F.

Dow



INDEX 979

ESTEBAN, A., ELio, F. J. De, CERDA, E., GOMEZ-ACEBO,E., and ANCTLLO, P. Blood-gas changes with differ-ent end-expiratory pressures in chronic bronchitis 159

EVANS, C , EVANS, M., and POLLOCK, A. V. The in-cidence and causes of postoperative jaundice 520

EVANS, C. J., DEWAR, J. A., BOYES, R. N., and SCOTT,D. B. Residual nerve block after i.v. regionalanaesthesia 668

EVANS, J. M., LATTO, I. P., and Ng, W. S. Acci-dental intra-arterial injection of drugs; a hazardof arterial cannulation 463

EVANS, M., see EVANS, C.EVANS, P. J. D., and KERH, J. H. Complications of

arterial cannulation and thermogenic assessment ofsequelae (ARS)318

ExaminationF.F.A.R.C.S. MARSHALL, M (C)324primary F.F JLR.CS (£) 83

Extradural blockblood concentrations of bupivacaine hydro-

chloride and carbonate. APPLEYARD, T. N.,et al 530

breech presentation in. BOWEN-SIMPKINS, P.,et al 420

bupivacaine 0.125% in labourVANDERICK, G., et al 838material and foetal plasma concentrations.

GEERINCKX, K., et al 937cardiovascular changes, in labour. CORALL, I. M.

et al (AR5)801continuous in labour, in presence of a M.W. plate

L1-L4. WALPOLB, J. B 163continuous spinal (inadvertent)

ABOULEISH, E (Q628DOCTOR, N. H (C)661CRAWFORD, J. S (C)82; 661

hypovolaemia on lignocaine absorption and c.v.responses. MORDZAWA, K-I., et al 631

lower limb reflexes in. BROMAGE, P. R 504myocardial performance with vasopressors by

non-invasive method. FORREST, A. L., et al. . . 662phaeochromocytoma. CODSINS, M. J., et al 78surgical induction of labour. CASEBY, N. G 747

Extrasystoles, see HeartEYAL, Z., see DAVIDSON, J. T.Eyes

intraocular pressure and halo thane. AL-ABRAK,M. H., et al 756

intraocular pressure and pentazocine. FUJITA, T.(C)627

FABIANI, G., see TORRI, G.Facial vasomotor behaviour. JOHNSTONE, M 765FARMAN, J. V. Anaesthesia and the E.M.O. system .. (i?)216Fat, brown in infants, and pulmonary equilibration of

cyclopropane. RACKOW, H., et al 35Feed-back monitoring. I l l : SUPPAN, P 829FELDMAN, S. A. Muscle relaxant* (Major problems ha

anaesthesia, VoL I) (.R)167FERGUSSON, I. L. C , see BOWEN-SIMPKTNS, P.FIDLER, K., see ROLLASON, W. N.Filters, bacteriological—for strain gauges. LACK, J. A.,

et al (C)704FISHER, A., see PRYS-ROBERTS, C.FITCH, W., see LEECH, P.FITZGERALD, B., see HARLAND, W. A.FLEMING, P. R. Cardiological aspects of preoperative

examination 555

Flow, see also Circulationmucus flow rates hi trachea. FORBES, A. R 29regional blood flow, see related organ, e.g. cerebral

blood flow, see Brain.Flunitrazepam

skills related to driving. KORTTILA, K., et al 961spinal anaesthesia supplement. PEARCE, C 877

Fofix, P., and PRYS-ROBERTS, C. Anaesthesia and thehypertensive patients 575

Interactions of beta-receptor blockadeand Pco, levels hi the anaesthetized dog 397

ROBERTS, J. G., CLARKE, T. N. S., BENNETT,M. J., and SANER, C. A. Is beta-adrenergic blockadecompatible with trichloroethylene anaesthesia? . . . 798

• , see ADAMS, A. P., see CLARKE, T. N. S., see KERR, J. H., see ROBERTS, J. G.

Forane, see IsofluraneFORBES, A. R. Mucus flow rates in trachea, effects of

inspired air temperatures, humidity and intubation 29FORREST, A. L., LAWSON, J. I. M., and OTTON, P. E.

Non-invasive technique of comparing myocardialperformance after extradural block and vaso-pressor therapy 662

FORRESTER, A. C. Redesigned Forrester spray (C)413Forrester spray, redesigned. FORRESTER, A. C (C)413Fox, D. E. R. Patient air intake valve (Q310FRANCE, C. J., PLUMER, M. H., EGER, E. I. u, and

WAHRENBROCK, E. A. Ventilatory effects of iso-flurane/halothane when combined with morphine,N tO and surgery 117

FRUMTN, M. J., see HALEVY, S.FRY, E. N. S. A lead tooth-bridge ( Q 5 4 3

Technique of orotracheal intubation (Q144FUJITA, M., see YAMAMURA, Y.FUJITA, T. Pentazocine and intraocular pressure hi

paediatrics (Q627Functional residual capacity, see also Respiration

during anaesthesia. HEWLETT, A. M., et al.I. methodology 479II: spontaneous respiration 486III: controlled ventilation 495

hi horses. MCDONNELL, W. N., et al (ARS)802FURNESS, R. M. B., see HOLDSWORTH, J. D.FYNN, R. W. Ketamine in management of lymphosar-

coma cutis 699

GGALINDO, A., and KENNEDY, R. Further observations

on depolarizing neuromuscular block: the so-calledphase II block 405

GALIZIA, E. J., and LAHIRI, S. K. Paraplegia aftercoeliac plexus block with phenol 539

GARRETT, R. T., see SDTTON, J. A.GAYA, H., see HOLDCROFT, A.GEDDES, I. C , see DUBOIS, M.GEERINCKX, K., VANDERICK, G., VAN STEENBERGE,

A. L., BouCHE, R., and D E MUYLDER, R. Bupiva-caine 0.125% hi extradural analgesia in labour,maternal and foetal plasma concentrations 937

, see VANDERICK, G.GENTSCH, H. H., see KARAMANIAN, A.GERRING, E. L., and SCARTH, S. C. Anaesthesia for

open heart surgery hi the calf 455GHONEIM, M. M., and PANDYA, H. Plasma protein

binding of bupivacaine and its interaction withother drugs hi man 435

GIBSON, P. F., see BAULD, H. W.GrLBERTON, A. A. Pulmonary artery catheterization

and wedge pressure hi intensive therapy 97

Dow




GILLICK, J. S. Atropine toxicity in a neonate 793GILLIES, I. D. S. Anaemia and anaesthesia 589

, see MORGAN, M.Glutamate dehydrogenase and inhalation anaesthetics.

BRAMMALL, A., et al 643GOLDMAN, J. A., see SCHOENFELD, A.G6MEZ-ACBBO, E., see ESTEBAN, A.GORDON, R. A. Anaesthesia and resuscitation: a manual

for medical students (i?)503GOULD, J. F., see JENKINSON, J. L.GOWDEY, C. W., 3ee LUNOY, P. M.GRAF, P. D., see JONES, J. G.GRANT, C. J., POWELL, J. N., and RADFORD, S. G.

Effects of halothane on DNA synthesis and mitosisin root tip meristems of Vicia faba 653

GREEN, R. A., and COPLANS, M. P. Anaesthesia andanalgesia in dentistry (i?)293

GSEENBAUM, R., see GRIFFITHS, D. P. G.GRBIBE, J., see KEHLET, H.GRBTCH, M., and JUSKO, W. J. Interpretation of drug

binding changes in relation to protein concentration(C)545GRIFFIN, D., see KING, J.GRIFFITH, H. B., see GRIFFITHS, D. P. G.GRIFFITHS, D. P. G., CUMMINS, B. H., GREENBAUM, R.,

GRIFFITH, H. B., STADDON, G. E., WILKINS, D. G.,and ZORAB, J. S. M. Cerebral blood flow and meta-bolism in nitroprusside induced hypotension 671

GROGONO, A. W. Assessment of albumin extravasationduring surgery (ARS)320

Drug interactions in anaesthesia 613New ventilator: a combined minute volume

divider and humidifier 432GROVB, L. H., see CAMPKIN, T. V.GYERMEK, L. Althesin toxicity in newborn animals . .(C)704

H

HAIGH, B. Penthrane in clinical anaesthesiology (i?) 65HALEVY, S., FRUMIN, M. J., ROSENTHAL, S., and

LEVTNE, W. G. Brain distribution, liver metabolismof hexobarbitone in genotype strains of mice 43

HALL, G. M., WHITWAM, J. G., and MORGAN, M.Effect of diazepam on experimentally induced painthresholds 50

, see LISTER, D.HALL, L. W., see MCDONELL, W. N.Halothane

arrhythmic doses of sympathomimetic drugs,compared to isoflurane. TUCKER, W. K., et al. . . 392

blood viscosity after anaesthesia. MAGORA, P.,et al 343

cardiovascular interactions with propranolol andhypoxacmia, ROBERTS, J. G., et al (ARS)32l

DNA synthesis and mitosis. GRANT, C. J., et al. . . 653induced hypotension

CO2 responsiveness of cerebral circulation.OKUDA, Y., et al (ARS)316

haemodynamics and pulmonary gas ex-change. PRYS-ROBERTS, C , et al 105

intracranial pressure effects. MISFELDT, B. B.,et al 853

intraocular pressure effects. AL-ABRAK, M. H.,et al 756

jaundice and repeated exposure (E) 1multiple exposures to. WEIGAND, H (C)544oxygen consumption and respiration. AL-ABRAK,

M. H., et al (ARS)321myocardial blood flow and O, consumption.

SMITH, G., et al 821postoperative jaundice. EVANS, C , et al 520ventilatory effects. FRANCE, C. J., et al 117

HALSEY, M. J. Physical chemistry applied to anaes-thetic action 172

BROWN, F. F. Anaesthetic—macromoleculeinteractions (ARS)805

JONES, J. G. Respiratory mass spectrometerusers' group (C)543

, see WHITE, D. C.HAMILTON, J. T., and BRYSON, J. S. Effect of ketamine

on transmembrane potentials of Purkinje fibres ofthe pig heart 636

HAMILTON, W. F. D., and ROBERTSON, G. S. Changesin serum uric acid related to the dose of methoxyflu-rane 54

, see ROBERTSON, G. S.HARGREAVES, M. D., see SMITH, W. D. A.

, see MAPLESON, W. W.HARLAND, W. A., HORTON, P. W., STRANG, R., FITZ-

GERALD, B., RICHARDS. J. R., and HOLLOWAY, K. B.Thyroxine release from the liver during anaesthesiaand surgery 818

HARRIS, E. A., SEEL YE, E. R., and BARRATT-BOYES,B. G. On the availability of oxygen to the bodyduring cardiopulmonary bypass in man 425

HARRISON, M. J., and HEALY, T. E. J. Intravenousadministration sets: the effect of flushing andfiltration on paniculate contamination 59

HEALY, T. E. J., see HARRISON, M. J.HEANEY, G. A. H. Pancuronium in maternal and foetal

serum 282Heart, see also Circulation

anaesthesia for open heart surgery in the calf.GERRING, E. L., et al 455

arrhythmias in dental anaesthesia. RYDER, W.,et al 760

arrhythmias in oral surgery and Althesin. ALEX-ANDER, J. P 770

arrhythmic doses of sympathomimetic drugsduring isoflurane and halothane anaesthesia.TUCKER, W. K., et al 392

cardiac output changes on intrapulmonaryshunting. SMITH, G., et al 337

cardiac output, dye dilution measurement"Dynamic" equilibration. JEBSON, P. J. R.,

et al (ARS)S00errors. TOMLIN, P. J., et al (ARS)800

cardiac surgery, Althesin and thiopentone.BROADLEY, J. N., ct al 687

cardio version, thiopentone with or withoutatropine, ORKO, R 947

congenital heart disease, venous admixtureassessment. OWEN-THOMAS, J. B., et al.. .(ARS)802

coronary artery surgery anaesthesia. VILJOEN,J. F., et al 953

Extrasy stoles and allied arrhythmias. SCHERF, D. (J?)104ketamine on action potentials of Purkinje fibres.

HAMILTON, J. T., et al 636myocardial blood flow and OB consumption

methohexitone. MCMILLAN, J. C , et al. . . 729halothane, SMITH, G., et al 821

myocardial performance in extradural blockade,a non-invasive technique. FORREST, A. L., et al. 662

nitroprusside on contractility and haemo-dynamics. ADAMS, A. P., et al 807

open heart surgery, viscosity in. ARONSON, H. B.,et al 722

pentazocine on papillary muscle. APPLEYARD,T. N (ARS)V}9

preoperative assessment. FLEMING, P. R 555HEATH, J. R., see HEWLETT, A. M.Helium-neon laser, breath alcohol measurement.

ALOBAIDI, T. A. A., et al iARS)317

Dow



INDEX 981

HENDERSON, P. D., see JEBSON, P. J. R.Heredity, senstivitity to barbiturates in inbred strains

of mice. HALBVY, S., et al 43HERMANS, J. M. H., see VRIES, W. J. K.HEWLETT, A. M., HULANDS, G. H., NUNN, J. F., and

HEATH, J. R. FRC during anaesthesia. II : Spon-taneous respiration 486

MnxEDGE, J. S. FRC during anaes-thesia. I l l : Artificial respiration 495

MINTY, K. B. FRC during anaesthesia.I: Methodology 479

HILL, D. W., see ALOBAIDI, T. A. A.HOGG, M. I. J.. DAVIES, J. M., MAPLESON, W. W.,

and ROSEN, M. Proposed upper limit of respiratoryresistance for inhalation apparatus 149

, see DAVIES, J. M.HOLDCROFT, A., LOH, H., and LUMLEY, J. Accept-

ability of swivel connectors 298LUMLEY, J., GAYA, H., DARLOW, M., and ADAMS,

D. J. Bacterial filters for mechanical ventilators (ARS)319HOLDSWORTH, J. D., FURNESS, R. M. B., and ROUL-

STON, R. G. A comparison of apomorphine andstomach tubes for emptying the stomach beforeG.A. in obstetrics 526

HOLLOWAY, K. B., see HARLAND, W. A.HORSEY, P. J. Lewin report (C)281HORSLEY, J. K., see Cox, L. A.HORTON, P. W. Radionuclidic techniques 217

, see HARLAND, W. A.HOUGH, J. M., see ROLLASON, W. N.HOWARD, P. J., see DUNDEE, J. W.HOWIE, H. B., see LOGAN, D. A.HULANDS, G. H., see BRAMMALL, A.

, see HEWLETT, A. M.Humidification

body heat loss. SHANKS, C. A 859; 863mucus flow rates in trachea. FORBES, A. R 29multiple gauze condensor humidifier in clinical

anaesthesia. SHANKS, C. A 773ventilator with humidifier. GROGONO, A. W. . • 432

Hyperbaric pressure, see PressureHyperpyrexia/hyperthennia, see TemperatureHypertension, see PressureHypnosis, Modern hospital hypnosis: especially for

anaesthetists. D. L. SCOTT (i?)386Hypoglycaemia, see Blood glucoseHypotension, see Pressure and Induced hypotensionHypothermia, see TemperatureHypovolaemia, see Blood

IISALO, E. U. M., see KANTO, J. H.Immunity, anaesthesia and lymphocyte transforma-

tion. KANTO, J., et al 733Induced hypotension

halothane-inducedcerebral circulation responsiveness to CO,.

OKUDA, Y., et al (ARS)316haemodynamics and pulmonary gas ex-

change. PRYS-ROBERTS, C , et al 105nitroprusside induced

acidosis. MCRAE, W. R., et al 795c.b.f. and metabolism. GRIFFITHS, D. P. G.,

et al 671toxicity. JACK, R. D (C)952

MCDOWALL, D. G (Q324; 327MERRIFIELD, A. J (C)324

Infection hazard from syringes. BLOGG, C. E., et al. . . 260Inferior vena cava occlusion in the left lateral position.

MALATINSKY, J., et al 165

Information retrieval systems. WINTERBURN, D. M. 784Inhalation anaesthetics, see also specific agents

anaesthetic molecules. RUDO, F. G., et al 181e.e.g. changes. KAVAN, E. M., et al 714E.M.O. system. FARMAN, J. V CR)216glutamate dehydrogenase and other enzymes.

BRAMMALL, A., et al 643intermolecular forces. MILLER, K. W 190solubility coefficients. STEWARD, A., et al (C)310

Inhalation analgesia, see Pain reliefIntensive care. WAHLIN, A., et al (R)783Intensive therapy, pulmonary artery catheterization

and wedge pressure. GILBERTSON, A 97Intermolecular forces. MILLER, K. W 190Intracranial pressure, see BrainIntravenous administration sets, see ApparatusIntravenous induction agents, see also specific agents

Althesin and barbiturates on neocortex andhippocampus in cats. KAYAMA, Y 912

Althesin and thiopentone in paediatric outpatientotology. SAARNTVAARA, L 268

plasma K+, Na+ and Cl~. BALI, I. M., et al 929recovery after thiopentone and Althesin. DUBOIS,

M., et al (_ARS)32OIntravenous regional anaesthesia, residual nerve block.

EVANS, C. J., et al 668Intubation of trachea, see TracheaIRELAND, J. T., see VIVORI, E.Isoflurane, arrhythmic doses of sympathomimetic

drugs. TUCKER, W. K., et al 392ventilatory effects. FRANCE, C. J., et al 117

JJAATTELA, A., see KEHLBT, H.JACK, R. D. Toxicity of sodium nitroprusside (C)952JAIN, P. D., see DATTA. P. K.JAMIL, A. K. Non-kink catheter mount (C)628JARVIS, J. D., see BLOGG, C. E.Jaundice, see LiverJEBSON, P. J. R., and HENDERSON, P. D. A "Dynamic"

calibration system for dye dilution cardiac outputmeasurement (ARS)800

, see BAULD, H. W.JBNKINSON, J. L., MACRAE, W. R., SCOTT, D. B., and

GOULD, J. F. Haemodynamic effects of diazepamused as a sedative in oral surgery 294

JEFHCOTT, G., and KERRY, R. J. Lithium, an anaes-thetic risk 389

JOHNSTONS, M. Digital vasodilatation: a sign ofanaesthesia 414

Facial vasomotor behaviour 765Methylphenidate on postoperative pain and

vasoconstriction 778JONES, J. G., LEMEN, R., and GRAF, P. D. "Airway

closure" in alloxan induced pulmonary oedema andraised left atrial pressure (ARS)321

, see HALSEY, M. J.JONES, P. L. Observations on N,O cylinders during

emptying 534JORGENSEN, P. B., see MISFELDT, B. B.JUDELMAN, H., and PDUE, D. H. Anaesthesia in a

patient with previous rngligr^t hyperpyrexia • • . .(C)519JUDSON, J. A. Changes in arterial Po, in one lung

anaesthesia (C)170JULIEN, R. M., see KAVAN, E. M.JUSKO, W. J., see GRETCH, M.

K

KADIS, L. B., see KATZ, J.KADLIC, T., see MALATINSKY, J.

Dow




KANTO, J. H., PIHLAJAMAKI, K. K., and IISALO,E. U. M. Concentrations of diazepam in adiposetissue of children (C)168

VAPAAVUORI, M., and VILJANEN, M. K.Mitogen-induced lymphocyte transfonnation aftergeneral anaesthesia 733

Plasma levels of diazepam after oral and i.m.administration (C)817

KARAMANIAN, A., KRAVATH, R., NAGASHIMA, H., andGENTSCH, H. H. Anaesthesia for "prune belly"syndrome 897

KATZ, J., and KADIS, L. B. Anaesthesia and uncommondiseases: Pathopkysiologic and clinical correlations • • (J?)246

KAVAN, E. M., JULIEN, R. M., and LUCERO, J. L.Persistent e.e.g. changes after some volatileanaesthetics 714

KAWAMATA, M., see YAMAMURA, Y.KAYAMA, Y. Althesin and barbiturates on the neo-

cortex and hippocampus in cats 912KEANEY, N. P., see MCDOWAIX, D. G.

KEEP, P. J., and MANFORD, M. L. M. Comparison ofAlthesin and methohexitone in paediatric anaes-thesia 685

A method of ventilation with Entonox inbronchoscopy 970

KB£RI-SZANT6, M. Mode of action of promethazinein potentiating narcotic drugs 918

KEHLET, H., ENGQUIST, A., and GRBIBE, J. Plasmavolume during surgery in unsupplementedglucocorticoid-treated patients 452

Nnau, P., JAATTELA, A., and TAKKI, S. Plasmacatecholamine concentrations during surgery inunsupplemented glucocorticoid-treated patients -. 73

KELMAN, G. R., NOTTAGE, B. J., SMITH, I., andSWAPP, G. H. Central venous pressure changesduring laparoscopy (AR5)801

KENNEDY, R., see GALINDO, R.KKRR, I. H. Preoperative chest X-ray 558KERR, J. H., SMITH, A. C , PRYS-ROBERTS, C.,

MELOCHE, R., and Fofix, P. Observations duringendobronchial anaesthesia. I I : Oxygenation . . . . 84

, see EVANS, P. J. D., see PRYS-ROBERTS, C.

KERRY, R. J., see JEPHCOTT, G.KESSELL, J., and ASSEM, E. S. K. An adverse reaction

to Althesin (C)209Ketamine, see also I.V. Induction agents

blood viscosity after anaesthesia. MAGORA, F.,et al 343

heart, action potentials of Purkinje fibres.HAMILTON, J. T., et al 636

in eclampsia. Rucci, F. S., et al (C)546in lymphosarcoma cutis. FYNN, R. W 699relaxant effect on trachea. LUNDY, P. M., et al. 333

Kidneyanaesthesia and transplantation. LOGAN, D. A.,

et al 69methoxyflurane

in obstetric analgesia, long term safety.ROSEN, M., et a l 827

osmolality and fluoride levels. ROBERTSON,G. S., et al 153

serum uric acid levels. HAMILTON, W. F. D.,et al 54

KIM, K. S., see VILJOEN, J. F.KING, J., and GRIFFIN, D. Suxamethonium apnoea,

serum cholinesterase activity and inhibitor numbers 908KLINGE, E., see ROSENBERG, P. H.KNIGHTS, K., see CORALL, I. M.

, see STRUNIN, L.

KNUSDEN, J., and RUBEN, H. Pulmonary complica-tions after long thoracic operations 752

KORTTILA, K., and LINNOILA, M. Skills related todriving after i.v. diazepam, flunitrazepam ordroperidol 961

KOUNIS, N. G. Bronchospasm induced by Althesinand pancuronium bromide (C)281

KRANTZ (jr). J- C , see RUDO, F. G.KRAVATH, R., see KARAMANIAN, A.KYEI-MENSAH, K., and THORNTON, J. A. Incidence of

medical disease in surgical patients 570KYLE, J. W.. see DUFFY, B. L.KYRIAKOV, K., see ENTRESS, A.

LACK, J. A., and LIVERANI, M. Bacteriological nitersfor strain gauges (C)704

Endotracheal tube resistances 461LAHIRI, S. K., see GALIZIA, E. J.LAL, H., see WASSHF, M. R.LANE, R., see MCDOWALL, D. G.

, see OKUDA, Y.LANGLEY, D. R., and STEWARD, A. Ventilation system

design and theatre air contamination with halothane 736Laparoscopy

c.v.p. changes in. KELMAN, G. R., et al (ARS)801Pao, in, with N,O and spontaneous breathing.

CORALL, I. M., et al 925LATTO, I. P., see EVANS, J. M.LAWSON, J. I. M., see FORREST, A. L.LECHNER, H., see MEYER, J. S.LEE, J. A., ATKINSON, R. A. Synopsis of anaesthesia. • (i?) 28LEECH, P., BARKER, J., and FITCH, W. Changes in

intracranial and systemic arterial pressures duringthe termination of anaesthesia (ARS)315

LEIGH, J. M., see CONWAY, C. M.LEMEN, R., see JONES, J. G.LEVINE, W. G., see HALEVY, S.LEVY, E., see SCHOENFELD, A.LEWIN report. HORSEY, P. J (C)281Lignocaine

absorption in extradural block with hypovolaemia.MORKAWA, K-L. et al 631

malignant hyperthermia. CLARKE, I. M. C , et al.(ARS)315

LINNOILA, M., see KORTTILA, K.LISTER, p . , HALL, G. M., and LUCRE, J. N. Cate-

cholamines in suxamethonium-induced hyper-thermic pigs (ARS)803

LITHIUM, an anaesthetic risk. JEPHCOTT, G., et al 389Liver

jaundicepostoperative. EVANS, C. J., et al 520repeated exposure to halothane (E) 1

metabolism of hexobarbitone in genotype strainsof mice. HALEVY, S.,etal 43

thyrootine release in anaesthesia. HARLAND, W. A.,et al 818

LIVERANI, M., see LACK, J. A.LLOYD, J. W., see PRYS-ROBERTS, C.Local anaesthesia, see also specific agents and

techniqueseditorial (£)707lorazepam and diazepam as oral premedicants.

MAGBAGBEOLA, J. A. 0 449lower limb reflexes in segmental extradural

analgesia. BROMAGE, P. R 504LOGAN, D. A., HOWIE, H. B., and CRAWFORD, J.

Anaesthesia and renal transplantation 69LOH, H., see HOLDCROFT, A.

Dow



INDEX 983

LONDON, M., see MAGORA, F.Lorazepam, as oral premedicant. MAGBAGBEOLA,

J. A. 0 449LUCERO, J. L., see KAVAN, E. M.LUCKE, J. N., see LISTER, D.LUMLEY, J., see BULKY, R. B.

, see HOLDCROFT, A., see MORGAN, M.

LUNDY, P. M., GOWDEY, C. W., and COLHOUN, E. H.Tracheal smooth muscle relaxant effect of ketamine 333

Lung, see also Respirationarterial catheterization and wedge pressure in

intensive therapy. GILBERTSON, A 97complications after long trans-thoracic surgery.

KNUSDEN, J., et al 752nitrogenation. WILDSMITH, J. A. W., et al 680oxygen toxicity (£)325preoperative chest X-ray. KERB, I. H 558response to endotracheal instillation of HC1/

Hartmann's solution. DAVIDSON, J. T., et al. . . 127shunting after varied cardiac outputs. SMITH, G.,

et al 337Lymphosarcoma cutis, ketamine in. FYNN, R. W 699Lysine acetylsalicylic acid, in postoperative pain.

VRIES, W. J. K., et al 133

M

MAC-Enflurane, effect of N,O. TORRI, G., et al 468MACRAE, W. R., and OWEN, M. Severe metabolic

acidosis after nitroprusside induced hypotension.. 795, see JENKINSON, J. L.

MAGBAGBEOLA, J. A. O. Comparison of lorazepam anddiazepam as oral premedicants for surgery underregional anaesthesia 449

ADADEVOH, B. K. Metabolic response to anaes-thesia and surgery in Nigerians: changes in plasmacortisol, insulin and blood sugar 942

MAGORA, F., LONDON, M., EIMERL, D., and ARONSON,H. B. Blood viscosity during anaesthesia withhalothane, cyclopropane, thiopentone and ketamine 343

PESSACHOVITCH, B., and SHOHAM, I. Sciatic nerveblock by the anterior approach 121

, see ARONSON, H. B.MALATINSKY, J., and KADLIC, T. Inferior vena caval

occlusion in the left lateral position 165Malignant hyperpyrexia, see TemperatureMANFORD, M. L. M., see KEEP, P. J.

, see SMITH, B. L.MANN, F. Acupuncture analgesia: report of 100

experiments 361MAPLBSON, W. W., ALLOTT, P. R., and STEWARD, A.

A non-feedback technique for programmedanaesthesia (ARS)805

SMITH, W. D. A., SIEBOLD, K., HARGREAVES,M. D., and CLARKE, G. M. Nitrous oxide anaesthesiaat atmospheric and hyperbaric pressures. Part I I :Comparison of measured and theoretical pharma-cokinetic data 13

, see HOGG, M. I. J., see SMITH, W. D. A., see STEWARD, A.

MARSHALL, M. F.F.A.R.CS. examination (C)324MARX, G. F., see ARCHER, O'r). G. W.Mass spectrometer respiratory, users' group. HALSEY,

M. J., et al (C)543MASSON, A. H. B., see WILDSMITH, J. A. W.MATHIAS, D. B., and WEDLEY, J. R. Cuffed endo-

tracheal tube effects on tracheal wall 849MATTIE, H., see VRIES, W. J. K.

MATTILA, M. A. K., RAJFAR, M., and PYSTYNEN, P.Diazepam as an adjunct in propanidid anaesthesiafor abortion 446

MCARDLE, G. K., see SUTTON, J. A.MCCAUGHEY, W., PANDIT, S. K., and MORRISON, J. D.

Benzoctamine (C)189MCDONELL. W. N., and HALL, L. W. FRC in

conscious and anaesthetized horses (AR5)802MCDOWALL, D. G., KEANEY, N. P., TURNER, J. M.,

LANE, J. R., and OKUDA, Y. Circulatory effects ofsodium nitroprusside (Q323

The toxicity of sodiumnitroprusside 327

, see OKUDA, Y.MCLACHLAN, M. S. F., see ROSEN, M.MCLELLAN, I. Hyperpyrexia caused by trimeprazine (C)252MCMILLAN, J. C., BROWN, D. M., SMITH, G., and

VANCE, J. P. The effect of methohexitone on myo-cardial blood flow and O, consumption in the dog.. 729

, see SMITH, G.MEADE, F., see OWEN-THOMAS, J. B.Medical disease

incidence in surgical patients. KYEI-MENSAH, K.,et al 570

selected references. THORNTON, J. A 623MEHTA, M. Intractable pain (R)262MELOCHE, R., see KERR, J. H.MELZACK, R. The puzzle of pain (i?) 53MERIN, G., see ARONSON, H. B.MERRIFIELD, A. J., and BLUNDELL, M. D. Toxicity of

sodium nitroprusside (C)324Metabolism

acidosis after nitroprusside induced hypotension.MACRAE, W. R., et al 795

i'C alphaxalone. STRUNIN, L., et al (ARS)319cerebral, in nitroprusside induced hypotension.

GRIFFITHS, D. P. G., et al 671drug metabolizing activity in theatre personnel.

WOOD, M., et al 726hepatic, and brain disposition of hexobarbitone in

genotype strains of mice. HALEVY, S., et al 43response to anaesthesia and surgery in Nigerians.

MAGBAGBEOLA, J. A. O., et al 942

Metaraminol, see Autonomic nervous systemMethohexitone

Althesin and, in paediatrics. KEEP, P. J., et al . . . 685myocardial blood flow and Ot consumption.

MCMILLAN, J. C , et al 729Methoxyflurane

analgesia in labour, long-term safety of. ROSEN,M., et al 827

Penthrane in clinical anaesthesiology. HAIGH, B. . . (R) 65serum uric acid levels. HAMILTON, W.F.D.,etal . 54urine osmolality and fluoride levels after.

ROBERTSON, G. S., et al 153Methylphenidate, postoperative pain and vasoconstric-

tion. JOHNSTONE, M 778Metoclopramide. DUNDEE, J. W., et al 509Metoclopramide with morphine and pethidine.

ASSAF, R. A. E., et al 514MEYER, J. S., LECHNER, H., REIVICH, M., and

EICHORN, O. Cerebrovascular disease (i?)503Microfilters, in blood transfusion. BULEY, R. B.,

et al (ARS)319MILLEDGE, J. S., see HEWLETT, A. M.MILLER, K. W., Intennolecular forces 190Minimum alveolar concentration, see MACMINTY, K. B., see HEWLETT, A. M.MISFELDT, B. B., JORGENSEN, P. B., and RISHOJ, M.

Nitrous oxide and halothane on intracranial pressurewith hypocapnia and intracranial disorders 853

Dow




Mitosis, halothane effects. GRANT, C. J., et al 653Mom, D. D. Pain relief in labour (R)201MOORE. J., and BALL, H. G. A sequential study of i.v.

analgesic treatment during labour 365MORGAN, M., LUMLEY, J., and GILLIES, I. D. S.

Neuroleptanaesthesia for major surgery: experiencewith 500 cases 288

, see HALL, G. M.MORIKAWA, K-I., BONICA, J. J., TUCKER, G. T., and

MURPHY, T. M. Effect of acute hypovolaemia onlignocaine absorption and c.v. response afterepidural (extradural) block in dogs 631

MORRELL, S. G., see DUNKIN, L. J.MORRIS, J. G. Thermodynamics of biological pro-

cesses 210MORRISON, J. D., see MCCAUGHEY, W.MUNSON, E. S. Transfer of N,0 into body air cavities 202

, see TUCKER, W. K.MURPHY, T. M., see MORIKAWA, K-I.Muscle relaxants, see Relaxants, and specific agentsMuscle, smooth muscle relaxant effect of ketamine on

trachea. LUNDY, P. M., et al 333Myaesthenic response in von Recklinghausen's

disease. BARAKA, A 701MYERS, E. N., see SMITH, R. B.

N

NAGASHIMA, H., see KARAMANIAN, A.Neonatal, see Paediatric and also ObstetricNervous system, see also Brain and Neuro-entries

acid-base changes in blood and c.s.f. in crani-otomy and hyperventilation. CAMPKIN, T. V.,et al 263

Cerebrovascular disease. MEYER, J. S., et al (R)503coeliac plexus block, paraplegia after. GALIZIA,

E. J . ,e ta l 539neuromuscular disease and anaesthesia. ELLIS,

F. R 603Neurophysiological background for anaesthesia.

BRAZIER, M (i?)246residual block after i.v. regional anaesthesia.

EVANS, C. J., et al 668sickle-cell trait, postoperative neurological com-

plication. DALAL, F. Y., et al 387Neuroleptanalgesia, awake intubation in a patient with

respiratory obstruction. ANAND, J. S (C)413Neuroleptanaesthesia for major surgery. MORGAN, M.,

et al 288Neuromuscular block/transmission, see also Relaxants

depolarizing block, phase II block. GALINDO, A.,et al 405

myaesthenic response in von Recklinghausen'sdisease. BARAKA, A 701

safety margin, indirect estimation. YAMAMURA, Y.,et al 902

Neuromuscular disease and anaesthesia. ELLIS, F. R. 603Neurophysiological background for anaesthesia. BRAZIER,

M (i?)246Neurosurgery. Advances in neurosurgery—1. SCHUR-

MANN, K., et al (i?)792NG, W. S., see EVANS, J. M.NICHOLAS, A. D. G., see APPLEYARD, T. N.NICHOLSON, J., see CORALL, I. M.NIKKI, P., see KBHLET, H.Nitroprusside sodium

acidosis after, induced hypotension. MACRAE,W. R., et al 795

c.b.f. and metabolism in induced hypotension.GRIFFITHS, D. P. G., et al 671

circulatory effects. McDowAix, D. G., et al (C)323

Nitroprusside sodium («mt.)myocardial contractility and haemodynamics.

ADAMS, A. P., et al 807toxicity

JACK. R. D (C)952MCDOWALL, D. G., et al 327MERRIFIELD, A. J (Q324

Nitrous oxidecylinders during emptying. JONES, P. L 534Entonox

valve resistance. DAVIES, J. M., et al 136; 145HOGG, M. I. J., et al 149

ventilation in bronchoscopy. KEEP, P. J. . . 970intracranial pressure

BARKER, J (C)116MISFELDT, B. B., et al 853

pharmacokinetic and e.e.g. data at atmosphericand hyperbaric pressures

SMITH, W. D. A. et al 3MAPLESON, W. W., et al 13

transfer into body cavities. MUNSON, E. S 202NOTTAGE, B. J., see KELMAN, G. R.NUNN, J. F., see HEWLETT, A. M.

, see PADMORE, G. R. A., see STURROCK, J. E.

OObstetric anaesthesia, see also Pain relief in labour

apomorphine/stomach tubes for emptyingstomach before G.A. HOLDSWORTH, J. D 526

arterial oxygen tensions during apnoea inpregnancy. ARCHER ftr), G. W., et al 358

breech presentation, lumbar extradural block in.BOWEN-SIMPKINS, P., et al 420

ketamine and eclampsia. Rucci, F. S., et al (C)546painless revolution (.5)391pancuronium in maternal and foetal sera.

HEANEY, G. A. H 282Obstetric analgesia, see Pain relief in labourOesophagus, traruoesophageal ultrasonic-monitoring of

circulation. TOMLIN, P. J., et al (ARS)318OKUDA, Y., MCDOWALL, D. G., ALI, M. M., and

LANE, R. CO, responsiveness of cerebral circulationduring halothane-induced hypotension in thebaboon (ARS)316

, see MCDOWALL, D. G.O'MALLEY, K., see WOOD, M.Operating theatre personnel, drug metabolizing

activity. WOOD, M., et al 726Operating theatre pollution, ventilation system.

LANGLEY, D. R., et al 736Oral, see DentalORDISH, P. M., see TWEEDIE, D. G.ORG.6368. BAIRD, W. L. M 658ORKO, R. Anaesthesia for cardioversion: thiopentone

with or without atropine 947Orotracheal tube connector, a fault. OSTERUD, A (C)952OSTERUD, A. Dangerous fault in disposable connector

for orotracheal tube (C)952OTTON, P. E., see FORREST, A. L.OWEN, M., see MCRAE, W. R.OWEN-THOMAS, J. B., and MEADE, F. Assessment of

venous admixture in congenital heart disease usingarterial blood gas tensions (ARS)802

Oxygen and Oxygenation, see also Respirationavailability during cardiopulmonary bypass.

HARRIS, E. A., et al 425consumption, effects of halothane. AL-ABRAK

M. H., et al (ARS)32lc.v. interactions of halothane, propranolol and

hypoxaemia. ROBERTS, J. G., ct al (ARS)32\

Dow



INDEX 985

Oxygen and oxygenation (com.)endobronchial anaesthesia. KERR. J. H., et al. • • 84laparoscopy with N,O and spontaneous breathing,

arterial tensions. CORRALL, I. M 925one lung anaesthesia

JODSON, J. A CQ170

THOMSON, D. F., et al (Q170Pao, during apnoea in pregnancy. ARCHER (jr)

G. W., et al 358toxicity, pulmonary ©^25warning device for failure. RICHIE, J. R (C)323

OYAMA, T. Anaesthetic management of endocrine disease(10431

PABARI, M., see CAMPKJX, T. V.PADFIELD, A. Thrombosis following diazepam (C)413PADMORE, G. R. A., and NDNN, J. F. SI units in

relation to anaesthesia 236Paediatric anaesthesia

Althesin and methohexitone. KEEP, P. J., et al... 685Althesin toxicity. GYBRMEK, L (C)7O4atropine toxicity. GILLICK, J. S 793bronchoscopic removal of foreign bodies. BARAKA,

A 124brown fat of infants in pharmacokinetics of

cyclopropane. RACKOW, H., et al 35preoperative hypoglycaemia. THOMAS, D. K. M. 66outpatient otology, Althesin and thiopentone.

SAARNTVAARA, L 268postoperative vomiting. SMITH, B. L., et al 373respiratory distress syndrome: survival after

pulmonary haemorrhage. ENTRESS, A., et al... 541transtracheal ventilation. SMITH, R. B., et al 313tubocurarine requirements in newborn and

plasma protein concentrations. VIVORI, E.,et al 93

PainIntractable pain. MEHTA, M (i?)262The puzzle of pain. MELZACK, R (R) 53

Pain reliefacupuncture. MANN, F 361drugs

see also specific agentsintravenous agents, sequential study in

labour. MOORE, J., et al 365minor gynaecological operations. SCHOEN-

FELD, A., et al 385promethazine potentiation of narcotic drugs.

KE&U-SZANTO, M 918vomiting after adenotonsillectomy. SMITH,

B. L.,etal 373in labour

breech deliveries, lumbar extradural block.BOWEN-SIMPKTNS, P., et al 420

bupivacaine 0.125% for extradural block.VANDERIOC, G., et al 838

bupivacaine 0.125% for extradural block,maternal and foetal plasma concentrations.GEERTNCKX, K., et al 937

continuous spinal, inadvertant. ABOULEISH,E (C)628

CRAWFORD, J. S (Q82; (Q661DOCTOR, N. H (C)661extradural block, c.v. changes. CORAIX, I. M.,

et al (ARS)801extradural block for induction. CASEBY,

N. G 747extradural block, in presence of M.W. plate

L1-L4. WALPOLE, J. B 163

Pain relief in labour (cont.)intravenous analgesics, a sequential study.

MOORE, J., et al 365methoxyflurane, long-term safety. ROSEN,

M..etal 827Obstetric analgesia and anaesthesia. BONICA,

J. J (i?)148Pain relief in labour. Mom, D. D C?)201

painless revoluton (£)391resistance of inhalation apparatus. DAVTES,

J. M., et al 136; 145HOGG, M. I. G., et al 149

postoperativelysine, acetyl sahcylate. VRIES, W. J. K., et al. 133methylphenidate. JOHNSTONE, M 778

Pain thresholds after diazepam. HALL, G. M., et al... 50Pancuronium, see also Relaxants

bronchospasm, KOUNIS, N. G (C)281in maternal and foetal serum. HEANEY, G. A. H. 282reaction to i.v. agents. TWEEDIE, D. G., et al (C)244

PANDIT, S. K., see MCCAUGHBY, W.PANDYA, H., see GHONFJM, M. M.Paraplegia, after coeliac plexus block. GALKIA, E. J.,

et al 539Parasympathetic effects, drugs and blockers; see

specific drugs and Autonomic nervous systemPATEL, S. M., see CASALE, F. F.Pathological and pharmacological considerations in

anesthesiology. BRECHNER, V. L (i?)245PATTERSON, T. J. S., see PRYS-ROBERTS, C.PAYNE, J. P., see AL-ABRAK, M. H.

, see ALOBAIDI, T. A. A.PEARCE, C. Respiratory effects of diazepam supple-

mentation of spinal anaesthesia in elderly males . . . 439Ro5-4200 (Flunitrazepam) as supplement for

spinal block in aged 877Pentazocine

intraocular pressure in paediatrics. FUJITA, T. . . (C)627minor gynaecological operations in. SCHOENFELD,

A., et al 385papillary muscle in-vitro. APPLEYARD, T. N. (ARS)799

PESSACHOVTTCH, B., see MAGORA, F.Phaeochromocytoma, see AdrenalsPharmacokinetics, see also Metabolism

Anesthetic uptake and action. E G E R , E . I (i?)460brain disposition of hexobarbitone in genotype

strains of mice. HALEVY, S., et al 43cyclopropane, role of brown fat. RACKOW, H.,

et al 35diazepam concentrations in fat. KANTO, J. H.,

etal (C)168N.O at atmospheric and hyperbaric pressures.

MAPLESON, W. W., et al 13SMITH, W. D. A., et aL 3

PharmacologyBiostatistics in pharmacology. DELAUNOIS, A. L. (i?)245Pathological and pharmacological considerations in

anesthesiology. BRECHNER, V. L (i?)245Phenylephrine, see Autonomic nervous systemPhysical chemistry, see ChemistryPIHLAJAMAKI, K. K., see KANTO, J. H.PmiE, D. H., see JUDELMAN, H.PLEUVRY, B. J., see WASSEF, M. R.PLUMER, M. H., see FRANCE, C. J.POLLIACK, A., see DAVIDSON, J. T.POLLOCK, A. V., see EVANS, C.Pollution in operating theatres, see Operating

theatresPostoperative drugs, vomiting after. SMITH, B. L.,

et al 373Postoperative hypoxaeniifl, pulmonary nitrogenation

effects. WILDSMITH, J. A. W., et al 680

Dow




Postoperative jaundice. EVANS, C., et al 520Postoperative pain relief, see Pain reliefPotassium, source in post suxamethonium hyper-

kalaemia. BALI, I. M., et al (ARS)803POTTER, D., see CORAIX, I. M.POWELL, D. R. Obstruction to endotracheal tubes • .(C)252POWELL, J. N., see GRANT, C. J.Premedicant drugs

benzoctamine. MCCAUGHEY, W., et al (C)189lorazepam and diazcpam with regional anaes-

thesia. MAGBAGBEOLA, J. A. 0 449metoclopramide. DUNDEE, J. W., et al 509metoclopramide with morphine and pethidine.

ASSAF, R. A. E., et al 514vomiting after adenotonsillectomy. SMITH, B. L.,

et al 373Preoperative assessment

biochemical screening tests. WHTTBY, L. G 564cardiological aspects. FLEMING, P. R 555chest X-ray. KERR, I. H 558editorial 547respiratory aspects. ANDERSON, W. G 549

Preoperative hypoglycaemia in children. THOMAS,D. K. M 66

Pressurearterial, see also Induced hypotension

changes during termination of G. A. LEECH,P., et al (ARS)315

changes, during experimental anaesthesia. WHITE,D. C , et al 196

hyperbaric NaO, phannacokinetic and e.e.g.data. MAPLESON, W. W., et al 13

SMITH, W. D. A., et al 3intracranial

N,O. BARKER, J (Q116changes in termination of G.A. LEECH, P.,

et al (ARS)315halothane and. MISFELDT, B. B., et al 853

intraocular and halothane. AL-ABRAK, M. H.,et al 756

venous-central, in laparoscopy. KELMAN, G. R.,et al (ARS)8Q1

PRESTON, T. D., see CONWAY, C. M.Procaine in malignant hyperthermia. CLARKB, I. M. C ,

et al (ARS)315Programmed anaesthesia, non-feedback technique.

MAPLESON, W. W., et al (ARS)805Promethazine, narcotic drug potentiation. KEERI-

SZANT6, M 918Propanidid, diazepam as an adjunct. MATTILA,

M. A. K., et al 446Propranolol, c.v. interactions with halothane and

hypoxaemia. ROBERTS, J. G., et al (ARS)321"Prune belly" syndrome, anaesthesia for. KARA-

MANIAN, A., et alPRYS-ROBERTS, C , LLOYD, J. W., FISHER, A., KERR,

J. H., and PATTERSON, T. J. S. Deliberate profoundhypotension induced with halothane: studies ofhaemodynamics and pulmonary gas exchange . . . .

, see ADAMS, A. P., see CLARKE, T. N. S.see FoEx, P.

, see KERR, J. H., see ROBERTS, J. G.

897

105

PYSTYNEN, P., see MATTILA, M. A. K.

RACKOW, E. H., and SALANTTRE, E. The pulmonaryequilibration of cyclopropane in infants and children:lack of functional brown a dispose tissue in the anaes-thetized surgical infant 35

RACKSTEIN, A. D., see TUCKER, W. K.RADFORD, S. G., see GRANT, C. J.Radiology

Notes on radiological emergencies. ANSELL, G... (i?)235preoperative chest X-ray. KERR, I. H 558

Radionuclidic techniques. HORTON, P. W 217RAJPAR, M., see MATTILA, M. A. K.RAMAMURTHY, S., see DALAL, F. Y.RAMSAY, M. A. E., see BLOGG, C. E.Recovery

driving skills after diazepam, flunitrazepam ordroperidol. KORTTILA, K., et aL 961

thiopentone and Althesin. DUBOIS, M., et al. (ARS)32QRegional anaesthesia, see Local anaesthesiaRETVICH, M., see MEYER, J. S.Relaxants, muscle

see also specific agents and also Neuromuscularblock

AH8165 for intubation. YOUNG, H. S. A., et al.(ARS)3ll

Muscle relaxants. FELDMAN, S. A (i?)167myasthenic response in von Recklinghausen's

disease. BARAKA, A 701ORG.6368 BAIRD, W. L. M. 658

Resistanceof airways, see Respirationof apparatus, see Apparatus

Respirationsee also Tung, Ventilation, Carbon dioxide and

Oxygenairway closure in pulmonary oedema. JONES,

J. G., et al (ARS)32lblood-gases with varied end-expiratory pressures

in bronchitis. ESTEBAN, A., et al 159circuit for SPPV in adults. WALLING, P. T., et al. 379diazepam and spinal block. PEARCE, C 439functional residual capacity in anaesthesia

HEWLETT, A. M., et al. I: Methodology... 479I I : Spontaneous respiration 486I l l : Artificial ventilation 495

functional residual capacity in horses. MCDONELL,W. N., et al (ARS)802

gas exchange and haemodynamics in halothane-induced hypotension. PRYS-ROBERTS, C , et al. 105

halothane effects. AL-ABRAK, M. H., et al.. .{ARS)32\intrapulmonary shunting after varied cardiac

outputs. SMITH, G., et al 337ketamine on tracheal muscle. LUNDY, P. M., et al. 333mass spectrometer users' group. HALSEY, M. J.,

etal (Q543new problems for old in the respiratory system.. (£)467one lung anaesthesia, Paoi in. JUDSON, J. A.

and also THOMSON, D. F., et al (C)170oxygenation in endobronchial anaesthesia. KERR

J. H.,et al 84Pao, during apnoea in pregnancy. ARCHER (jr),

G. W.,etal 358post-traumatic distress. STODDART, J. C , et al. . . 892prediction of Pa<;oi in circle system without CO,

absorption. SCHOLFIELD, E. H., et al 442preoperative assessment. ANDERSON, W. G 549pulmonary nitrogenation effects. WILDSMITH,

J. A. W., et al 680respiratory distress syndrome, survival after

pulmonary haemorrhage. ENTRESS, A., et al.. • 541respiratory flowmeter. BOUCHER, R. F (AR5)805respirometers, electronic

Cox, L. A., et al 302CONWAY, C. M-, et al 885

Retiral of Dr J. E. Riding (£) 1REULEN, H. J., see SCHURMANN, K.

Dow



INDEX 987

Review articlesanaemia and anaesthesia. GILLIES, I. D. S. • • . . 589anaesthesia and hypertensive patients. Fofex, P.,

et al. 575anaesthesia and medical disorders, selected refer-

ences. THORNTON, J. A 623anaesthetic molecules. RUDO, F. G., et al 181biochemical screening tests. WHTTBY, L. G. . . 564cardiological preoperative examination. FLEMING,

P. R. 555drug interactions in anaesthesia. GROGONO,

A. W 613effects of changes in temperature and pressure

during experimental anaesthesia. WHITE,D. C , et al 190

incidence of medical disease in surgical patientsKYEI-MENSAH, K., et al 570

influence of disease on anaesthesia, symposium No. 8information retrieval systems. WINTERBURN,

D. M 784intermolecular forces. MILLER, K. W 190neuromuscular disease and anaesthesia. ELLIS,

F. R 603physical chemistry applied to anaesthetic action.

HALSEY, M. J 172physical chemistry, symposium No. 3preoperative chest X-ray. KERR, I. H 558radionuclidic techniques. HORTON, P. W 217respiratory preoperative assessment. ANDERSON,

W. G 549SI units in relation to anaesthesia. PADMORE,

G. R. A., et al 236thermodynamics of biological processes. MORRIS,

J. G 210transfer of N,O into body air cavities. MUNSON,

E. S 202Reviews of books, see Book reviewsRICHARDS, J. R., see HARLAND, W. A.RICHARDSON, D. J., see BOWEN, D. J.RIDING, Dr J. E., retiral (E) 1RITCHIE, J. R. A warning device for failing oxygen

pressure (C)323RISHOJ, M., see MISFELDT, B. B.Ro5^1200, see FlunitrazepamROBERTS, J. G., FoEx, P., CLARKE, T. N. S., PRYS-

ROBERTS, C , and BENNETT, M. J. Cardiovascularinteractions of halothane, high dose propranolol andhypoxaemia in the dog (ARS)321

, see ADAMS, A. P., see CLARKE, T. N. S., see FotX P.

ROBERTSON, G. S., and HAMILTON, W. D. F. Urineosmolality and fluoride levels after methoxyfluraneanaesthesia 153

, see HAMILTON, W. F. D.ROBINSON, J. S., see Cox, L. A.ROLLASON, W. N., FIDLER, K., and HOUGH, J. M.

Althesin in outpatient dentistry 881R6SEN, M., ASSCHER, A. W., MCLACHLAN, M. S. F.,

and WILLIAMS, L. A. Long-term safety of methoxy-flurane analgesia in labour 827

, see DAVTES, J. M., see HOGG, M. I. J.

ROSENBERG, P. H., and KLINGE, E. Enflurane effectson biogenic monoamines in brain and plasma ofrats 708

ROSENTHAL, S., see HALEVY, S.ROULSTON, R. G., see HOLDSWORTH, J. D.RUBEN, H., see KNUDSEN, J.RUBIN, R. B., see COUSINS, M. J.RUBIN, S., see DAVIDSON, J. T.

Rucci, F. S., and CAROLI, G. Ketamine and eclampsia(C)546

RUDO, F. G., and KRANTZ (jr), J. C. Anaestheticmolecules 181

RUSSELL, W. J., see CHALMERS, C.RYDER, W., and TOWNSEND, D. Cardiac rhythm in

dental anaesthesia 760

SAARNTVAARA, L. Comparison of Althesin and thio-pentone in anaesthesia for paediatric outpatientotology 268

SALAM, A. A., and DAVIES, D. M. Acute adrenalinsufficiency during surgery: a case report 619

SALANTTRE, E., see RACKOW, H.Salicylates, Lysine acetyl salicylate in postoperative

pain. VRDZS, W. J. K., et al 133SAMUEL, I. O., see ASSAF, R. A. E.SAMUEL, J. R., see AL-ABRAK, M. H.SANER, C. A., see FoEx, P.SAVEGE, T. M., see WALLING, P. T.SCARTH, S. C , see GERRTNG, E. L.SCHAER, H., and BACHMANN, U. Ionized calcium in

acidosis: differential effect of hypercapnic and lacticacidosis 842

SCHERF, D., and SCHOTT, A. Extrasystoles and alliedarrhythmias (i?)104

SCHMIDT, G. B., see DALAL, F. Y.SCHOENFELD, A., GOLDMAN, J. A., and LEVY, E.

Pentazocine and diazepam analgesia for minorgynaecological operations 385

SCHOLFIELD, E. J., and WILLIAMS, N. E. Prediction ofPaOoa using a circle system without CO, absorp-tion 442

SCHOTT, A., see SCHERF, D.SCHURMANN, K., BROCK, M., REULEN, H. J., and

VOTH, D. Advances in neurosurgery—1 (R)792Sciatic nerve block, anterior approach. MAGORA,

F.,etal 121SCOTT, D. B., see EVANS, C. J.

, see JENKINSON, J. L.SCOTT, D. L. Modern hospital hypnosis: Especially for

anaesthetists (i?)386SEELYE, E. R., see HARRIS, E. A.Sequential study of i.v. analgesics in labour. MOORE,

J., et al 365SHANKS, C. A. Clinical anaesthesia and the multiple

gauze condenser-humidifier 773Humidification and body heat loss in anaesthesiaI: Quantification and correlation in the dog . . . . 859II: Effects in surgical patients 863

SHARMA, D., see DATTA, P. K.SHERMAN, H., see SMITH, R. B.SHOHAM, I., see MAGORA, F.Sickel-cell trait, postoperative neurological complica-

tion. DALAL, F. Y., et al 387SDZBOLD, K., see SMITH, W. D. A.SI units. PADMORE, G. R. A., et al 236SMITH, A. C , see KERR, J. H.SMITH, B. L., and MANFORD, M. L. M. Postoperative

vomiting after paediatric adenotonsillectomy: asurvey of incidence following differing pre- andpostoperative drugs 373

SMITH, G., CHENEY, F. W., and WINTER, P. M. Theeffect of change in cardiac output on intrapulmonaryshunting 337

VANCE, J. P., BROWN, D. M., and MCMILLAN,J. C. Canine myocardial blood flow and Oa con-sumption after halothane 821

, see MCMILLAN, J. C.

Dow




SMITH, I., see KELMAN, G. R.SMITH, R. B., MYERS, E. N., and SHERMAN, H.

Transtracheal ventilation in paediatric patients.... 313SMITH, W. D. A., MAPLESON, W. W., SDZBOLD, K.,

HARGREAVES, M. D., and CLARKE, G. M. Nitrousoxide anaesthesia at atmospheric and hyperbaricpressures, pharmacokinetic and e.e.g. data 3

, see MAPLESON, W. W.Snake bite, CASALE, F. F., et al 162Sodium nitroprusside, see NitroprussideSolubility coeflScients for inhaled anaesthetics.

STEWARD, A., et al (C)310SPIERDIJK, J., see VRIES, W. J. K.Spinal anaesthesia

flunitrazepam supplement. PEARCE, C 877inadvertent, continuous

ABOULEISH, E (C)628CRAWFORD, J. S 82; (C)661DOCTOR, N. H (Q661

respiratory effects of diazepam. PEARCE, C 439STADDON, G. E., see GRIFFITHS, D. P. G.STEER, B., see EDWARDS, E. M.STEVENSON, I. H., see WOOD, M.STEWARD, A., ALLOTT, P. R., COWLES, A. L., and

MAPLESON, W. W. Solubility coefficients for inhaledanaesthetics for water, oil and biological media . .(C)310

, see LANGLEY, D. R., see MAPLESON, W. W.

STEWART, H. C , see WOOD-SMITH, F. G.STODDART, J. C , and WARDLE, E. N. Post-traumatic

respiratory distress due to endotoxinaemia andintravascular coagulation 892

STRANG, R., see HARLAND, W. A.STRUNIN, J. M., see STRUNIN, L.STRUNIN, L., STRUNIN, J. M., KNIGHTS, K., and WARD,

M. E. Metabolism of 14C-labelled alphaxalone inman (ARS)319

, see CORALL, I. M.STURROCK, J. E., and NUNN, J. F. Effect of anaesthesia

on DNA synthesis in Chinese hamster fibroblasts(ARS)316

SUBRAHMANYAM, H. S. Effects of bitemporal electricalstimulation on the duration of suxamethoniumapnoea in man 934

SUPPAN, P. Feed-back monitoring. I l l : Control ofhalothane administration by respiratory patterns • • 829

SUTTON, J. A., GARRETT, R. T., and MCARDLE, G. K.A survey of reported adverse reactions to Althesin

(ARS)806Suxamethonium, see also Relaxants

apnoeaclectroconvulsive therapy. SUBRAHMANYAM,

H. S 934prolonged. BAULD, H. W., et al 273serum cholinesterase numbers. KING, J.,

et al 908SWAPP, G. H., see KELMAN, G. R.Swivel connectors. HOLDCROFT, A., et al 298Sympathetic effects, drugs and blockers; see Auto-

nomic nervous system and also AdrenalsSynopsis of anaesthesia. LEE, J. A., ct al (i?) 28Syringes, infection hazard from BLOGG, C. E., et al... 260

T

TAKKI, S., see KEHLET, H.TAYLOR, P. A., see BROADLEY, J. N.Temperature

blood haemolysis. CHALMERS, C , et al 742changes and experimental anaesthesia. WHITE,

D. C . etal 196

Temperature (corn.)heat loss and humidification. SHANKS, C. A... 859; 863hypothermia after trimeprazine

MCLELLAN, I (Q252ZSIGMOND, E. K rC)705

hypothermia in vascular surgery. WEDLEY, J. R. (C)713inspired air on mucus flow rates in trachea.

FORBES, A. R. 29malignant hyperthermia

anaesthesia in a patient with past attack.JUDELMAN, H.,etal (Q519

catecholamines in pigs. LISTER, D., et al. {AR5)803procaine and lignocaine in therapy. CLARKE,

I. M. C , et al (ARS)315with trimeprazine. ZSIGMOND, E. K (C)705

MCLELLAN, I (C)252Thermodynamics of biological processes. MORRIS,

J. G 210Thiopentone, see also I.V. Induction agents

Althesin and, in cardiac surgery. BROADLEY, J. N. 687blood viscosity. MAGORA, F., et al 343cardioversion with/without atropine. ORKO, R. . . 947paediatric outpatient otology. SAARNTVAARA, L. 268recovery after. DUBOIS, M., et al (ARS)32O

THOMAS, D. K. M. Hypoglycaemia in children beforeoperation: its incidence and prevention 66

THOMPSON, J. M., see TOMLEN, P. J.THOMSON, D. F., and CAMPBELL, D. Changes in

arterial Po, in one lung anaesthesia (Q170THORNTON, J. A. Anaesthesia and medical disorders,

selected references 623, sec KYEI-MENSAH, K., see WITT, A.

Thyroxine release from liver during anaesthesia.HARLAND, W. A., et al 818

TOMLIN, P. J., and DUCK, F. Transoesophagealultrasonic monitoring of circulation [ARS)318

THOMPSON, J. M., and CLARDDGE, E. Systematicerrors in dye-dilution measurement of cardiacoutput (ARS)800

Tonometer, new, thin film CHALMERS, C , et al. . . 253Tooth-bridge of lead. FRY, E. N. S (C)543TORRI, G., DAMIA, G., and FABIANI, M. L. Effect of

N,O on the anaesthetic requirement of enflurane • • 468TOWNSEND, D., see RYDER, W.Toxicity, see also Complications

AlthesinKESSELL, J., et al (Q209newborn, GYERMEK, L (Q7C4SUTTON, J. A., et al (ARS)806TWEEDIE, D. G., et al (C)244

atropine in a neonate. GILIICK, J. S 793drugs

metabolizing activity in theatre personnel.WOOD, M., et al 726

pursuit of a chimera (£)247halothane, repeated exposure and jaundice . . . . (E) 1jaundice, postoperative. EVANS, C , et al 520lithium of. JEPHCOTT, G., et al 389methoxyflurane

analgesia, long-term safety. ROSEN, M.,et al 827

scrum uric acid. HAMILTON, W. D. F., etr>l. 54urine osmolality and fluoride. ROBERTSON,

G. S., et al 153nitroprusside

JACK, R. D (C)952MCDOWALL, D. G., etal 327; (C)323MACRAE, W. R., et al 795MERRIFIFXD, A. J (C)324

Dow



INDEX 989

Toxicity (cont.)pancuronium. TWBEDIE, D. G., et al (C)244pulmonary oxygen toxicity (£)325trimeprazine, hypothermia

MCLELLAN. I (C)252ZSIGMOND, E. K (Q705

Tracheacuffed endotracheal tubes on tracheal wall.

MATHIAS, D. B., et al 849endotracheal tube

obstruction. POWELL, D. R (Q252resistances. LACK, J. A 461

intubation using AH8165. YOUNG, H. S. A., et al.(AR

intubation with neuroleptanalgesia in presence ofrespiratory obstruction. ANAND, J. S (C)413

mucus flow rates, effects of inspired air tem-peratures, humidity and intubation. FORBES,A. R 29

relaxant effect of ketamine. LUNDY, P. M., et al... 333technique of orotracheal intubation. FRY, E. N. S.

(O144transtracheal ventilation in paediatrics. SMITH,

R. B.,etal 313Transoesophageal ultrasonic monitoring of the

circulation. TOMLIN, P. J., et al (.ARS)118Transplantation, renal, anaesthesia. LOGAN, D. A.,

et al 69Transtracheal, see TracheaTrauma, post-traumatic respiratory distress. STOD-

DART, J. C , et al 892Trichloroethylene, see also Inhalation agents

beta-adrenergic blockade. FoiX P., et al. • -(ARS)798Trimeprazine, hyperthermia

MCLELLAN, I (C)252ZSIGMOND, E. K (C)705

Tubocurarine, see also Relaxantsrequirements in newborn and plasma protein

concentrations. VIVORI, E., et al 93TUCKER, W. K., RACKSTEIN, A. D., and MUNSON,

E. S. Comparison of arrhythmic doses of adrenalinemetaraminol, ephedrine and phenylephrine duringisoflurane and halothane anaesthesia in dogs 392

TURNER, J. M., see MCDOWALL, D. G.TWEEDIE, D. G., and ORDISH, P. M. Reactions to

intravenous agents (Althesin and pancuronium).. (C)244

U

Uncommon diseases, Anaesthesia and uncommondiseases. KATZ, J., et al (i?)246

VANCE, J. P., see MCMILLAN, J. C., see SMITH, G.

VANDERICK, G., GEERINCKX, K., VAN STEENBERGE,A. L., and DE MUYLDER, E. Bupivacaine 0.125%in extradural analgesia in labour 838

, see GEERTNCKX, K.VAN DER VLIET, A., see WAHLIN, A.VAN STEENBERGE, A. L., see GEERTNCKX, K.

, see VANDERICK, G.VAPAAVUORI, M., see KANTO, J.Veins, see also Intravenous

central venous pressure in laparoscopy. KELMAN,G. R.. et al (ARS)801

inferior vena caval occlusion in left laterialposition. MALATTNSKY, J., et al 165

VELLA, F. Mechanical stability of serum cholinesterase(Q837

Venous admixture, assessment in congenital heartdisease. OWEN-THOMAS, J. B., et al (ARS)802

Ventilation, see also Respirationartificial

FRC. HEWLETT, A. M., et al 495fiberoptic bronchoscopy. EDWARDS, E. M.,

etal (Q628Elapid snake bite. CASALE, F. F., etal 162

blood-gases with varied end-expiratory pressuresin bronchitis. ESTEBAN, A., et al 159

hyperventilation, acid-base changes in blood andc.s.f. CAMPKIN, T. V., et al 263

CHRISTHNSEN, M. S 348isoflurane/halothane. FRANCE, C. J., et al 117spontaneous

FRC. HEWLETT, A. M., et al 486laparoscopy with N,O, Pa<,j in. CORALL,

I. M 925PPB circuit for adults. WALLING, P. T., et al. 379

transtracheal, in paediatrics. SMITH, R. B., et al. 313Ventilation system in theatres and pollution. LANGLEY,

D. R., etal 736Ventilators

bacterial filters. HOLDCROFT, A., et al (ARS)319new with humidifier. GROGONO, A 432

Vessels, see also Arteries and Veinsdigital vasodilatation. JOHNSTONE, M 414facial vasomotor behaviour. JOHNSTONE, M 765myocardial performance, vasopressors and extra-

dural block. FORREST, A. L., et al 662vascular surgery, hypothermia in. WEDLEY, J. R. (C)713vasocon8triction, methylphenidate. JOHNSTONE,

M 778vasopressors with extradural block, myocardial

performance. FORREST, A. L., et al 662VICKERS, M. D., see WOOD-SMITH, F. G.VnjANEN, M. K., see KANTO, J.VILJOEN, J. F., ESTAFANOUS, F. G., and KIM, K. S.

Anaesthesia for emergency coronary artery surgery 953Visual reaction time after cerebral angiography.

DUNKTN, L. J., et al 867VIVORI, E., BUSH, G. H., and IRELAND, J. T. Tubo-

curarine requirements and plasma protein con-centrations in the newborn infant 93

Volatile anaesthetics, see Inhalation anaesthetic agentsand specific agents

Vomiting, after adenotonsillectomy in relation withpre-and postoperative drugs. SMITH, B. L., etal. . . 373

von Recklinghausen's disease, myasthenic response.BARAKA, A 701

VOTH, D., see SCHURMANN, K.VRIES, W. J. K., SPIERDIJK, J., MATTIE, H., and

HERMANS, J. M. H. A new soluble acetylsalicylicacid derivative in the treatment of postoperativepain 133

W

WAHLIN, A., WESTERMARK, L., and VAN DER VLIBT,A. Intensive care (i?)783

WAHRENBROCX, E. A., see FRANCE, C. J.

WALLING, P. T., and SAVEGE, T. M. Preliminaryexperience with a circuit to increase airwayspressure in adults breathing spontaneously 379

WALPOLE, J. B. Continuous epidural (extradural)block in labour in presence of a M.W. plate fromL1-L4 163

WALTERS, F. J. M., see CONWAY, C. M.WARD, M. E., see STRUNIN, L.WARDLE, E. N., see STODDART, J. C.

Dow




WASSEF, M. R., LAL, H., and PLEUVRY, B. J. Cardio-vascular effects of ergometrine in the experimentalanimal in vivo and in vitro 473

WEBB, D. A., see CONWAY, C. M.WEDLBY, J. R. Hypothermia in vascular surgery . . . .(C)713

, see MATHLAS, D. B.WBIGAND, H. Multiple exposure to halothane (C)544WESTERMARK, L., see WAHLIN, A.WHITBY, J. D. t see DUNKIN, L. J.WHTTBY, L. G. Biochemical screening tests for

anaesthetists 564WHITE. D. C , and HALSEY, M. J. Effects of changes in

temperature and pressure during experimentalanaesthesia 196

WHTTWAM, J. G., see BIRD, B. D., see CHALMERS, C., see HALL, G. M.

WrLDSMiTH, J. A. W., and MASSON, A. H. B. Someeffects of maintaining pulmonary nitrogenation inanaesthesia 680

WILKINS, D. G., see GRIFFITHS, D. P. G.WILLIAMS, J., see BIRD, B. D.WILLIAMS, L. A., see ROSEN, M.WILLIAMS, N. E., see SCHOLFIELD, E. J.WINTER, P. M., see SMITH, G.

WINTERBURN, D. M. Information retrieval systems:a guide 784

WITT, A., and THORNTON, J. A. In-vivo effects ofanaesthetic agents on kidney enzymes (ARS)804

, see A P P L B Y A R D , T . N .W O O D , M . , O ' M A L L E Y , K... and STEVENSON, I. H .

D r u g metabolizing ability in theatre p e r s o n n e l . . . . 726W O O D - S M I T H , F . G., VICKERS, M . D . , and STEWART,

H. C. Drugs in anaesthetic practice (i?)201

YAMAMURA, Y., KAWAMATA, M., and FUJITA, M.Indirect estimation of safety margin in neuro-muscular transmission 902

YOUNG, H. S. A., CLARKE, R. S. J., and DUNDEE, J. W.Tracheal intubation using AH8165: a comparisonwith suxamethonhim (ARS)317

ZORAB, J. S. M., see GRIFFITHS, D. P. G.ZSIGMOND, E. K. Malignant hyperthermia caused by

trimeprazine (C)705

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..[Fortral] should be theoral analgesic of choice

in the treatment ofpost-operative pain.'

Brit J. Anaesth. (1974) 2:149-152.

Rapid effect when given by mouthLess nausea and vomiting than with opiates

Unlikely to lower Wood pressureMinimal risk of severe respiratory depression

I=QRTRALOrally effective post-op analgesic

Each Fortral capsule contains 50mg pentazocine hydrochloride. 'Fortral' Is a registered trade mark. Full information available fromyour Chief Pharmacist or on request from the Medical Information Department, Winthrop Laboratories, Surbiton-Upon-Thamss,

Surrey. KT6 4PH.

WINTHROP

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BRITISH JOURNAL OF ANAESTHESIAVOLUME 47, No. 4 Published monthly * APRIL 1975

Annual subscription {post free): UJC. and Eire £10.50; Overseas £12.50; U.S. and Canada £12.50Subscription Department, Macmilkm Journals Ltd, Brunei Road, Basingstoke, Hampshire RG21 2XS, England

CONTENTS

EDITORIAL: Spinal anaesthesia ...D. B. Scott and J. T. Thorbum

... 421

ORIGINALThe solubility of halothane in canine blood and

tissues ... ... ... ... ... ... 423A. Steward, P. R. AUott and W. W, Mapleson

The effect of seven vasopressors on halothaneMAC in dogs 435E. P. Steffey and E. I. Eger

A new method for the measurement of carbondioxide in the expired air ... ... ... 439J. A. Bushman, S. Askill, H. Serafinowicz andB. James

A comparison of methods for the measurement ofcardiac output and blood oxygen content ... 443I. H. S. Douglas, J. A. E. MacDonald, G. F.Milligan, A. Mellon and I. Me A. Ledtngham

Evaluation of RX 72601 as an anti-curare agent 451G. Metcalf and P. W. Dettmar

CLINICALRecovery and skills related to driving after intra-

venous sedation: dose-response relationshipwith diazepam ... ... ... 457K. Korttila and M. Limoila

Studies of drugs given before anaesthesia. XXV:Medazepam, a new benzodiazepine ... ... 464R. A. E. Assaf, J. W. Dundee and I. M. Bali

Anatomical factors in difficult direct laryngoscopy 468A. White and P. L. Kander

Morphological and biochemical defects in musclesof human carriers of the malignant hypcr-thermia syndrome ... ... 475H. Isaacs and J. J. A. Heffron

A return to trichloroethylene for obstetric anaes-thesia 482J. S. Crawford and P. Davies

Postoperative hypoxaemia and oxygen therapy ... 491G. B. Drummond

A simple method for computing acid-base state 500J. P. Blackburn, T. D. Preston and D. A. P.Strickland

The effect of non-depolarizing muscle relaxantson plasma potassium ... ... ... ... 505/. M. Bali, D. L. Coppel and J. W. Dundee

Changes in serum uric acid concentrations afterCaesarean section using methoxyflurane ... 508W. F. D. Hamilton, G. S. Robertson and D.Campbell

The speed of onset and potency of Althesin ... 512/. W. Carson, J. W. Dundee and R. S. J.Clarke

A study of the changes in serum potassium con-centration with suxamethonium using differentanaesthetic agents ... ... ... ... 516V. J, Dhanaraj, J. Narayanamurthy, C. Sitadeviand K. M. Rao

CASE REPORTSProlonged block with recovery after extradural

analgesia for labour 520G. V. Pathy and M. Rosen

Anaphylaxis to suxamethonium: two case reports 5237. M. Mandappa, P. M. Chandrasekhara andR. G. Nelvigi

EUROPEAN COMMENTARYThe pain clinic: an interdisciplinary team ap-

proach to the problem of pain ... ... ... 526H. U. Gerbershagen, R. Frey, F. Magin, W.Schott and N. Muller-Suur

CORRESPONDENCESolubility of halothane in dog blood ... ... 530Arterial oxygen tension in parturient women ... 530

EDITORIAL BOARD page ii

MACMILLAN JOURNALS LTD, 4 LITTLE ESSEX STREET, LONDON WC2R 3LF

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