Adaptive resistance to targeted therapies in cancer

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Transcript of Adaptive resistance to targeted therapies in cancer

© Translational lung cancer research. All rights reserved. Transl Lung Cancer Res 2013;2(3):152-159www.tlcr.org

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Review Article

Adaptive resistance to targeted therapies in cancer

Rafael Rosell1,2, Niki Karachaliou2, Daniela Morales-Espinosa3, Carlota Costa2, Miguel Angel Molina2, Irene Sansano2,4, Amaya Gasco5, Santiago Viteri5, Bartomeu Massuti6, Jia Wei7, María González Cao5, Alejandro Martínez Bueno5

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153Translational lung cancer research, Vol 2, No 3 Jun 2013

© Translational lung cancer research. All rights reserved. Transl Lung Cancer Res 2013;2(3):152-159www.tlcr.org

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154 Rosell et al. Adaptive resistance in cancer

© Translational lung cancer research. All rights reserved. Transl Lung Cancer Res 2013;2(3):152-159www.tlcr.org

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ERK signaling

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Other feedback systems involving insulin growth

factor receptor (IGFR) and mammalian target of

rapamycin (mTOR)

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155Translational lung cancer research, Vol 2, No 3 Jun 2013

© Translational lung cancer research. All rights reserved. Transl Lung Cancer Res 2013;2(3):152-159www.tlcr.org

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KRAS*

EGF

BRAFv600E

MEK

ERKSpry2

DUSP6

PI3K*

AKT

MTORC1

S6K1

elF4E

4EBP1

EGFR*

GDC-0980

GOLPH3

FBXW7

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156 Rosell et al. Adaptive resistance in cancer

© Translational lung cancer research. All rights reserved. Transl Lung Cancer Res 2013;2(3):152-159www.tlcr.org

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157Translational lung cancer research, Vol 2, No 3 Jun 2013

© Translational lung cancer research. All rights reserved. Transl Lung Cancer Res 2013;2(3):152-159www.tlcr.org

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Adaptive resistance in NSCLC driven by EGFR

mutations

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158 Rosell et al. Adaptive resistance in cancer

© Translational lung cancer research. All rights reserved. Transl Lung Cancer Res 2013;2(3):152-159www.tlcr.org

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Acknowledgements

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159Translational lung cancer research, Vol 2, No 3 Jun 2013

© Translational lung cancer research. All rights reserved. Transl Lung Cancer Res 2013;2(3):152-159www.tlcr.org

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