Abstract Book - International Pharma Conference & Expo ...

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Reignite Conferences

International

Pharma Conference (Pharma-2020)

August 26-27,2020 Online Conference

Pharma-2020


International



Abstract Book

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About Us

Reignite Innovative Conferences has been registered under the Telangana state of India. We are here

to provide a great platform to all the academic people, researchers, scientists, and research scholars

to discuss on latest innovations and research progress involved in all the branches of science.

Through this platform, we want to explore new ideas and techniques for the development of the

global world along with protecting nature which provides a better life for human beings.

We are providing a good opportunity for young researchers by providing special space to discuss

with eminent speakers one-on-one about what they are working on, and they may even give you

advice on how to enhance your own work.

Our goal is to gather all the eminent speakers and young aspiring minds from all over the world to

share knowledge, providing good networking, and provide access to various activities related to a

particular subject with current findings and developments.

Reignite aims to give a great service to all businesspeople, entrepreneurs, industrialists to exhibit

their products and providing an opportunity for cost-effective marketing. We perceive that every

brand is unique and unusual in its own way. So, we recognize brand objectives, and all other needs

to provide a satisfactory result. We not only believe in doing excellent work but also providing the

best service to our esteemed clients. Launch your product through our platform and forge your

business relationships. We are conducting the B2B meetings which are an adaptable and fast way to

engage your guests in meaningful networking discussions with people who are truly relevant for

your businesses and projects. We deliver a spectacular hospitality experience to the attendees.

Why Reignite:

• To share ideas and innovative thoughts

• Engage in high-level debates and refine your ideas

• Networking and build your knowledge base

• Explore yourself among this tremendously growing scientific world

• Providing a holistic experience of academic tourism

• Meet esteemed experts and influencers face to face

• Expand Your Resources

• Help Institutions or Organizations to organize the successful International

Conferences/National Conferences/Seminars/Workshops

• Cost-effective marketing

• Chance to collaborate with research organizations and industries

• Encounter new vendors and suppliers

• Product promotion activities

• Strengthen your brand recognition

Note: We did not publish full-length articles. The presented research abstracts will be

published in the conference abstract book.

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Keynote Presentation Sessions Wednesday, August 26, 2020 (Day-1)

Keynote Lecture 1……………………………………………… 5 Thursday, August 27, 2020 (Day-2)

Keynote Lecture 2………………………………………………. 25

Oral Presentation Sessions & Poster Presentation Wednesday, August 26, 2020 (Day-1)

Session 1: Pharmaceutical Research and Development, Pharmacology and

Toxicology…………………………………………………………... 6

Session 2: Drug Discovery Design and Development, Drug Delivery,

Pharmacy Practice, Pharmacology, Neuro Pharmacology and

Psychopharmacology……………………………………………. 6

Thursday, August 27, 2020 (Day-2)

Session 1: Pharmacy Practice, Pharmacology, Drug Screening and Discovery,

Drug Design and Development……………………………... 26

Session 2: Novel Drug Delivery System, Pharmacology, Drug Screening and

Discovery, Pharmacy Practice………………………………. 26

Contents

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Keynote Abstracts

Day-1

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Bacteriocin: An Unexplored Source of Drugs for the Treatment of Hospital Acquired Infections

Sabiha Imran,

Department of Biotechnology, Manav Rachna International Institute of Research and Studies, India

Abstract:

The soil microorganisms have been greatly exploited for their antibiotics to combat and destroy disease causing

microbes. The interaction of microbes, their competition for nutrients, survival, and quorum sensing are all

phenomenon having a biochemical basis. Since their discovery in the first half of the 19th century, antibiotics have

been extensively used as therapeutic agents and growth promoters. Their efficacy and cost-effectiveness contribute

to their popularity. Nevertheless, the continuous use of antibiotics has resulted in the emergence of multidrug-resistant

microbial strains that no longer respond to antibiotic therapy. A number of strategies have been explored to control

microbial pathogens without the use of antibiotics. Bacteriocins are antimicrobial, proteinaceous compounds with a

bactericidal mode of action against bacteria closely related to the producer strain. There are a wide variety of

bacteriocins produced by different bacterial genera that must be further studied. As bacteriocins have been thought

as alternative bioactive substances to avoid the broad side-effects and alarming resistance dissemination produced by

the use of classical antibiotics.

The incorporation of bacteriocins as bioactive compounds in a pharmaceutical product needs different type of studies

to demonstrate the non-existence of adverse effects, which must be performed both in vitro and in in-vivo

experimental systems.

The emergence of multidrug resistance in this bacterium is a crucial therapeutic problem and worsens the prognosis

of their disease. The emergence of multidrug resistance in this bacterium is a crucial therapeutic problem for these

patients and worsens the prognosis of their disease. The specific multi-resistant gram-negative pathogens most

commonly associated with nosocomial acquired infections were in respiratory tract, surgical-site infection, and in

urinary tract infection. Many promising aspects with respect to the bacteriocins as a promising drug for the treatment

of hospital acquired multi drug resistance pathogens are presented.

Biography: Dr Sabiha Imran is an Associate professor in the Department of Biotechnology. She did her post-graduation, M. Sc and M. Phil

in Biotechnology and PhD in Microbiology. Her area of specialization is Medical Biotechnology and Immunology. She has more

than sixteen years of research and teaching experience. She got first position in M.Sc. Biotechnology. She has attended and

presented research papers in many national and international conferences as an invite and Lead Speaker and was given best paper

presentation awards in January 2020 in an International Conference at Aligarh Muslim University, Aligarh, India and in 2008 in

a National Conference at AIIMS, New Delhi. She had been invited in an International Conference on Clinical Virology and

Infectious Diseases in Dubai as a keynote speaker, moderator, and a member of organizing committee in 2017. She has twenty-

nine publications in reputed Scopus and Web of Science indexed national and international journals. A start up ‘Organic Farm

fresh’ from New Gen IEDC Dept of Biotechnology, GOI was awarded March 2019 to the students of Biotechnology under her

mentorship. She is a qualified Registered Microbiologist of Canadian College of Microbiology (RMCCM).

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Scientific Session Abstracts

Session 1 & 2 Day 1

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Session 1&2 Day 1-August 26,2020 Pharmaceutical Research and Development, Pharmacology and Toxicology

Drug Discovery Design and Development, Drug Delivery, Pharmacy Practice, Neuro Pharmacology &

Psychopharmacology and Pharmacology Title: Pharmacological Management of Xerostomia in Sjogren’s Syndrome Patients - A Meta-Analysis

Name: Anuja Kammari, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre, India

Title: Teratogenic Potential and Prenatal Developmental Toxicity of Medicinal Plants during Pregnancy

Name: Mohammed A Alshawsh , University of Malaya, Malaysia

Title: Production and Purification Strategies for Microbial Fibrinolytic Enzymes

Name: Erumalla Venkatanagaraju, School of Sciences, CHRIST (Deemed to be University), India

Title: Development and Characterization of Lemongrass Oil Loaded Microemulsion Based Gel for Treatment of

Superficial Fungal Infections

Name: Jeet Gandhi, Kadi Sarva Vishwavidyalaya, India

Title: Migraine and Neurological Triggers

Name: Sreelakshmi Sreekumar, Nirmala College of Pharmacy, India

Title: Balancing Product and Process Patenting – A Pharma Perspective

Name: Sivaram Hariharan, PSG College of Pharmacy, India

Title: Efficacy and Sustainability of Blood Pressure Control

Name: Jisa Elizabeth Sabu, Nirmala College of Pharmacy, India

Title: Molecular and Genetic Mechanism of Hemophagocytic Lymphohistiocytosis

Name: Angelin Jaimon Augustine, Nirmala College of Pharmacy, India

Title: Comparative Efficacy and Cost-Effectiveness of Anemia Management among Chronic Kidney Disease Patients

Name: Savitha R S, JSS College of Pharmacy, India

Title: Surgical Prophylaxis of Antibiotics in Orthopedic Procedures

Name: Shubham Babu Gupta, Lovely Professional University, India

Title: Preformulation Detailing on Novel Buccal Drug Delivery by Use of Effervescent Technology

Name: K Pansuriya, K B Institute of Pharmaceutical Education and Research, India

Title: The Use of SSRI’s Linked to Violent Crime Conviction?

Name: Aneeta Jeeson, Nirmala College of Pharmacy, India

Title: Effect of Host Genetics on the Second Genome: The Gut Microbiota

Name: Christy Sojan, Nirmala College of Pharmacy, India

Title: Ministry of AYUSH, Govt. of India Recommended Anti-viral Formulations and Herbs from Siddha System of

Medicine for COVID 19 – A Review

Name: S D Muralidass, Siddha Physician, Arumbakkam, India

Title: Ewing’s Sarcoma’s Inception with Paraplegia: An Unusual Anamnesis

Name: Niveena Varghese, Nirmala College of Pharmacy, India

Title: Brain Plasticity in Neuropsychological Disorders: Mechanism and Genetic Interventions

Name: Benita John, Nirmala College of Pharmacy, India

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Pharmacological Management of Xerostomia in Sjogren’s Syndrome Patients – A Meta-Analysis

Anuja Kammari,

Department of Oral Medicine and Radiology, Panineeya Mahavidyalaya Institute of Dental sciences and Research

Centre, India.

Abstract:

Aim & objectives: Sjogren’s syndrome is an immunologic disorder, characterized by symptoms of dry mouth and dry

eyes, that can be primary or secondary to connective tissue diseases such as rheumatoid arthritis, systemic lupus

erythematosus, polymyositis, and systemic sclerosis. Management of xerostomia is more difficult & Secretogogues are

the pharmacologic agents that increase the salivary flow. The aim of the present study is analysis of pharmacotherapy

in management of xerostomia in patients with Sjogrens syndrome and to compare and evaluate the efficacy of these

drugs in improving saliva flow rate and to identify optimal treatment option for management of xerostomia in SS

patients

Material & methods: A Meta-analysis of Case-control studies was conducted on Pharmacological management of

xerostomia or dry mouth in patients with Sjogrens Syndrome & the collected data is subjected to exclusion & inclusion

criteria & Mean Difference (MD), Odds ratio and confidence intervals (95% CI) were calculated by fixed and random

effects model from the data of 3 studies.

Results & conclusion:

Results were statistically analysed & will be presented.

Biography:

Kammari Anuja is a student currently pursuing her master’s degree in Oral Medicine and Radiology at Panineeya Mahavidyalaya

Institute of Dental Sciences. She has participated in a study on early detection of malignant lesions and lesions with malignant

potential in a community setting in India using Velscope, Collaborative research with TWO WORLDS Cancer research

organization, Canada. She has authored 4 publications in peer-reviewed journals and was awarded the best review for the article

published in JIAOMR 2019.

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Teratogenic Potential and Prenatal Developmental Toxicity of Medicinal Plants During Pregnancy

Mohammed A. Alshawsh1*, Siti Rosmani Md Zain2, Abdulmannan H. Fateh3 1Department of Pharmacology, University of Malaya, Malaysia. 2Department of Anatomy, University of Malaya, Malaysia. 3Department of Pharmacology, University of Malaya, Malaysia.

Abstract:

Herbal medicine has been practised since ancient times. Nowadays, medicinal herbs still have popular demand among

the consumers, particularly in China, Africa, and India. According to the WHO 70% of the world population relies on

herbal sources for treatment and prevention of illnesses. Traditionally, women consume herbs during pregnancy for

overall well-being and to encourage healthy pregnancies, however there is a lack of evidence about its safety and

efficacy. There is a common misconception about the safety of herbs and many people belief it has better safety profile

as compared to synthetic drugs. Many studies recently reported the potential teratogenicity and prenatal developmental

toxicity of several medicinal plants. Our group has investigated the potential embryo-fetal developmental toxicity in

vivo of two medicinal plants commonly consumed by women in Malaysia during the pregnancy with a belief it’s safe

and it exhibit health benefits. Findings showed that the plant extracts exhibited mutagenic effects and significantly

decreased number of corpora lutea with a higher incidence of pre-and post-implantation loss as compared to control

group. Various congenital anomalies in foetuses were reported including micrognathia, stunted growth, subcutaneous

haemorrhages, umbilical hernia, and deleterious alteration on reproductive performance were observed in rats. Thus,

consumption of herbal medicine should be avoided during pregnancy and educated public about the harmful uses of

herps during pregnancy is crucial.

Biography:

Dr. Mohammed Alshawsh is currently working as Associate Professor at Department of Pharmacology, Faculty of Medicine,

University of Malaya, Malaysia. His current field of research interest mainly focuses on pharmacological investigations of

flavonoids and other polyphenol for the treatment of colorectal cancer, obesity, diabetes, and fatty liver diseases using animal

models and in vitro cell culture studies and investigating the gene expression profiling to unravel the underlying molecular

mechanisms. He is also doing safety and toxicology studies. He serves as Associate Editor for the BMC Complementary Medicine

and Therapies Journal. He supervised 7 PhD and 1 Master students to completion; currently, he is supervising 5 PhD students and

2 Master students. He has published over 50 papers in peer-reviewed journals with an h-index of 13 and has given over 20 invited

and plenary lectures at international conferences. He has obtained several research grants, such as UMRG, BKS, PPP and FRGS.

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Production and Purification Strategies for Microbial Fibrinolytic Enzymes

Erumalla Venkatanagaraju,

School of Sciences, CHRIST (Deemed to be University), India.

Abstract:

Microbial fibrinolytic proteases today occupy a place of prominence among biocatalysts owing to their ability to catalyse

blood clots. A failure of haemostasis and consequent formation of blood clots in the circulatory system can produce

severe outcomes such as stroke and myocardial infraction. Specificity of these enzymes has caused tremendous interest

among scientists and industrialists. Fibrinolytic proteases from a large number of bacterial, fungal and a few plant and

animal sources have been purified to homogeneity. This has enabled their successful sequence determination and their

three-dimensional structure leading to a better understanding of their unique structure-function relationships during

various hydrolytic and synthetic reactions. Since protein purification is normally done in a series of sequential steps

involving a combination of different techniques, the effect of sequence of steps and the number of times each step has

to be performed needs optimisation. The methodological strategies discussed here will be of immense help during

fibrinolytic protease production and purification.

Keywords: Blood clots, Fibrinolytic proteases, Stroke, Purification, Characterization

Biography:

Dr. Erumalla Venkatanagaraju working as an Assistant Professor in School of Sciences, CHRIST (Deemed to be University). Dr.

Erumalla was awarded as fellow of Scholars Academic and Scientific Society, 2018, Distinguished Young Faculty award by

Vision Group of Science and Technology, Karnataka, India, 2019 and outstanding scientist award by VDGood technologies,

2020 for his significant contribution in industrial biotechnology. He received his Ph.D. on Microbial Therapeutic Enzymes

Production from the University of Acharya Nagarjuna and did his Postdoc at Institute of Nano Science and Technology, India. Dr.

Erumalla has vast experience in bioprospecting of industrial important microorganisms for production of therapeutics and

biofuels. He published over 60 papers in peer reviewed journals and book chapters. One of his eminent achievement was

production of bioethanol from laboratory waste in an eco-friendly manner, funded by Karnataka State Council for Science and

Technology (KSCST) and Vision Group of Science and Technology (VGST) and obtained 2 patents. He is also an editor for 13

national and international journals. He is serving as a member for Indian Pharmaceutical Association, Association of Microbiologists

of India, Association of Biotechnology and Pharmacy, World Society Interdisciplinary Anti-Aging Medicine and Scholars

Academic Scientific Society. Dr. Erumalla was invited as a speaker for several national and international conferences.

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Development and Characterization of Lemongrass Oil Loaded Microemulsion Based Gel for

Treatment of Superficial Fungal Infections

Jeet Gandhi*, Pragna Shelat, Punit Parejiya

Kadi Sarva Vishwavidyalaya, India.

Abstract:

Exploration of natural resources from biological metabolites of plants as an alternative to synthetic chemical moieties

has proved to emerge as an ailment to various disorders. One of such are essential oils from plants that are belied to

have immense medicinal values and have a potential to treat various disorders. One of a kind is lemongrass oil essential

oil which is believed to have excellent mosquito repellent activity, perfumery and reported to have strong antifungal

property. the objective of present study is to develop and characterize the topical micro emulsion-based formulation

containing lemon grass oil. The lemongrass oil formulation developed using pseudo ternary phase diagram and

optimized by D-optimal design possessing 1.10% of oil, 6.1% of Smix and 91.3% of water was clear transparent light

to pale yellow microemulsion with globule size of 14.60 ± 0.31 nm, zeta potential of 0.94 mV and PDI value 0.00133

indicating a stable microemulsion. The light to pale yellow coloured microemulsion based gel showed a drug release of

99.63 ± 0.41% within 180 minutes with retention of drug in skin layers of about 64.99 ± 0.42% and on the skin about

16. 39 ± 0.25% after 12 hours indicating the retention of drug at site of action. The skin irritation study and stability

study indicated a non-irritant and stable MBG formulation at 40°C/75% RH for 6 months. Hence it can be said that the

lemongrass oil loaded microemulsion based formulation can be used for treatment of fungal infections.

Keywords: Lemongrass oil, microemulsion based gel, candida albicans

Biography:

Mr. Jeet Gandhi is a research scholar at Kadi Sarva Vishwavidyalaya pursuing a PHD degree in Pharmaceutics and Pharmaceutical

technology department at Kadi Sarva Vishwavidyalaya, Gandhinagar 382023. The research comprises of exploration of lemongrass

oil as an antifungal agent as the potential of the essential oils as an ailment in the medicinal therapeutics remains under the shadow.

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Migraine and Neurological Triggers

Sreelakshmi Sreekumar*, Bharat Mishra,

Kerala University of Health Science, India.

Abstract:

Migraine is a chronic neurological disease with several trigger factors including hormonal changes, dietary, and

environmental factors. It occurs in stages and can last for several days. In most cases, family history is an essential

diagnostic tool. It often starts at puberty and is worst during middle age. People with migraine illness have a nervous

system that is not working normal. This overreacts to stimuli and when gets stimulated leads to an unusual wave of brain

that leads to headache. Majority of migraine sufferers face a dilemma with a specific part of nervous system known as

Trigeminal nerve. The irregular wave whilst stimulates several different stimuli and the stimulus are irrational signals

from other parts of nervous system such as stress, irregular sleep, a flashing light, a range of food ingredients, weather

changes, and noise do contribute necessarily to instigate the neurological triggers which ultimately results in migraine.

On the contrary, migraine may occur simultaneously without triggers. Migraine can be chronic, which may show

symptoms that results in occurrence of migrainous headache for at least 15 days per month. The risk factors or comorbid

illnesses in patients with migraine include stroke, sub-clinical vascular brain lesions, CHD, hypertension, psychiatric

diseases (depression, anxiety, bipolar disorder, panic disorder and suicide), restless leg syndrome, epilepsy and asthma.

Trigger factors are frequent in migraine patients and its evasion may decrease headache frequency and improve patients’

quality of life.

Biography:

Sreelakshmi Sreekumar, currently pursuing Pharm D (2nd year) at Nirmala College of Pharmacy, Muvattupuzha, Ernakulam, Kerala

is a student speaker with a significant interest in research field of Pharmacology. She was also a presenter in a National Conference:

A Paradigm Shift for Emerging Paraphernalia in advancement of cancer research which was held at Nirmala College of Pharmacy,

Kerala in the month of February 2020. She holds a great skill in presentation, and public speaking.

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Balancing Product and Process Patenting – A Pharma Perspective

Sivaram Hariharan*, M Ramanathan, and V Sankar

PSG College of Pharmacy, India

Abstract:

Post 2005, which ushered in the regime of Product Patenting in the Indian manufacturing sector, lots of things have

changed. More importantly, the future of small generic pharmaceutical manufacturing units that thrived in the period

prior to this regime has come into focus. While the benefits of the current regime has been emphasized that it would

bring fresh impetus into Drug Discovery efforts into the pharmaceutical sector, the astronomical and ever mounting

costs of high quality research in this context, could still give the huge multinational pharmaceutical conglomerates with

their vast financial chests of billions a big edge and could potentially translate into monopoly and bring along with it

unaffordable prices of essential drugs. This would then translate into a case of who came in first and others would

forever be in the catching up game. That is why a balance is essential in this regard. A few suggestions like not

abolishing the earlier process patent regime could be tabled for further discussions by experts. These measures could

give new start-ups as well as other existing smaller and medium sized pharmaceutical companies much needed impetus

to compete in the market as well as come up with novel pharmaceutical products.

Biography:

Dr Sivaram Hariharan is a Professor of Pharma Chemistry at PSG College of Pharmacy. His research interests are in the field of

Pharma Chemistry as well as Pharma Education and has interests in certain legal aspects of the profession, especially Patenting

concerning Pharma Research. He has publications in reputed journals and has also published an article in Nature Asia. Dr Sivaram

is also a prolific writer of fiction with works to his credit that have been well received by readers. His books are listed on Amazon

and Goodreads.

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Efficacy and Sustainability of Blood Pressure Control

Jisa Elizabath Sabu*, Bharath Mishra, Jismy Jaison,

Kerala University of Health and Sciences, India.

Abstract:

Hypertension is a serious medical condition where the blood pressure is highly abnormal, being a major risk

factor for CVD and other complications. Studies have demonstrated the relationship between BP and CVD

with no evidence, but more robust for systolic BP ie, 2/3 of HT patients (adults) have a higher risk for

experiencing CVD. The pathophysiology reveals genetic background. Primary hypertension includes multiple

type of genes, allelic variants, and positive family history. It is usually asymptomatic, and probability increases

with aging and increase in atherosclerosis. Diagnosis enabled by repeated BP measurements and assessment

of CVD risk, target organ damage and concomitant clinical conditions. If the cause can be accurately

diagnosed for secondary hypertension then patients can achieve normalization of BP and reduction in CVD

risk. Hypertension also results in risks to Chronic Kidney Disease. Reducing BP in adults with a high BP

provides potential to prevent at least the age-related tendency for individuals to develop HT. Patient's global

CVD risk and comorbidities should be considered in determining the need for pharmacologic antihypertensive

treatment. JNC 8 guidelines have provided new recommendation in the treatment therapy in which patients

should receive a dosage adjustment and combinations of the 4 first-line therapies. Triple therapy with an ACE

inhibitor or ARB, CCB and thiazide- type diuretics. As hypertension is considered as a major cause of

premature deaths and indeed a major health burden worldwide, a targeted approach is required to improve the

control over hypertension.

Biography:

Ms. Jisa Elizabath Sabu is a first year PharmD student from Nirmala College of Pharmacy, Muvattupuzha, India.

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Molecular and Genetic Mechanism of Hemophagocytic Lymphohistiocytosis

Angelin Jaimon Augustine*, Bharat Mishra

Kerala University of Health and Sciences, India

Abstract:

Hemophagocytic Lymphohistiocytosis is an unconventional form of Hemopoietic disorder which was initially thought

to be dominated and seen in children than in adults. But recently it’s known to be more significant in adults, with all age

groups been affected. This is a hyper inflammatory Syndrome as well as a Cytokine Storm Syndrome. The aetiology of

this respective disease can be of Primary type expressly inherited form which is the Familial Hemophagocytic

Lymphohistiocytosis (FHL) and Secondary type that can be caused due to viral infections (Epstein-Barr virus),

autoimmune diseases, Malignancy, Macrophage Activation Syndrome (MAS) etc. If not treated properly both the type

may or may not lead to terminal multiple organ failure. The genes involved in the genetic mechanism of FHL is FHL1,

FHL2 (PFR1), FHL3 (UNC13D), FHL4 (STX11) and FHL5 (STXBP2 (UNCI8B)). Transport, processing and function

of cytotoxic granules in natural killer cells and cytotoxic T lymphocytes is associated with albinism affect that’s perhaps

due to the genetic defect and immunodeficiency syndromes. Among the genetic HLH, from FHL2 to FHL5 genetic

defects have been identified and all these gene are involved in Cytotoxic Granule Exocytosis or Function. Whereas the

chances of this ailment due to FHL1 gene is scarce. Most of the genetic mutations were seen in FHL2 with an alteration

in its corresponding protein perforin with a bi allelic PRF1 mutations and few in SH2D1A gene with an alteration in

SH2 domain–containing protein 1A. The disease had shown gender equivalence and estimation of universal generality

of one in a count of 50,000. The genetic form is most likely to be present in the paediatric population and with some

exceptional in adult population.

Biography:

Angelin Jaimon Augustine, a second year PharmD student from Nirmala College of Pharmacy, Kerala, India, is a student speaker

with keen interest in research field especially in pharmacology and pharmacotherapeutics where she has shown sincere interest and

dedication. She was a co- author for a presentation which was done for the World Conference on Epidemiology – Infectious Diseases

and Public Health, London, UK and also she was a e- poster presenter in a National Conference: A Paradigm Shift For Emerging

Paraphernalia in Advancement of Cancer Research, Nirmala College of Pharmacy, Kerala, India Apart from studies and researcher,

Angelin Jaimon Augustine was an active student in cultural activities and public speaking.

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Comparative Efficacy and Cost-Effectiveness of Anemia Management Among Chronic Kidney Disease

Patients

Savitha R S1*, Subbalakshmi MR2, Madhan Ramesh3, Manjunath S Shetty4, Chetan CS4 1,2,3Department of Pharmacy Practice, JSS College of Pharmacy, India. 3,4Department of Nephrology, JSS Medical College and Hospital, India.

Abstract:

Background: Anemia is the frequent and severe complication in ESRD patients which may accelerate progression of

CKD. Though, there are enough studies in the anemia of CKD patients, the management of anemia between non-dialysis

and dialysis CKD patients differ.

Objectives: The goal of this study is to assess safety, efficacy and cost-effectiveness of anemia management in non-

dialysis dependent CKD patients (NDD-CKD) and dialysis dependent patients (DD-CKD). Methodology: A

Prospective Observational study was conducted in the tertiary care teaching hospital over a period of 9 months. All

admitted inpatients and those visiting ambulatory haemodialysis centres who met inclusion criteria were reviewed and

enrolled into the study. The patients were followed up from the day of admission /first visit to the next follow up for the

hemoglobin levels and safety of the drugs. The Hb values were compared using two-tailed t-test with significance level

at < 0.05. Results: Of the 350 patients enrolled into the study, the number of patients in NDD-CKD was 113 (32%) and

DD-CKD was 237 (68%). Male patients were more in the study i.e., 78 (69%) in NDD and 163 (69%) in DD patients.

Most of the patients were of age group of 41-60. The average number of medications prescribed were 2.09±0.92 (NDD)

and 1.84±0.75 (DD). The most commonly reported reaction to anemia treatment was Fever (43%). The baseline Hb was

7.90±1.30 and 8.31±1.27 and the follow up Hemoglobin was 9.23±0.99 and 8.92±1.16 in NDD-CKD and DD-CKD

group at 95% CI 0.38-0.81, and p= <0.0001 respectively. The blood transfusion was observed to be most cost effective

for anemia management among both groups.

Conclusion: The anemia therapy was more effective in the non- dialysis dependent patients when compared to dialysis

patients of the population.

Key words: Chronic Kidney Disease, Anemia, Non dialysis and Dialysis, Prescribing patterns, Treatment outcomes.

Biography:

Mrs. Savitha R S has been associated with College of Pharmacy, Mysuru at JSS Academy of Higher Education & Research since

May 2007. She is currently involved in teaching pathophysiology, pharmacotherapeutics and clinical pharmacokinetics apart from

other courses. She has also experimented with different classroom teaching practices that allow for both student- directed as well as

self-regulated learning with the support of in-house learning management system. She has attended national and international

conferences where she has presented research papers in the area of pharmacoepidemiology, outcomes research and pharmacy

practice. She has worked in the area of pharmaceutical care and pharmacoeconomics in renally impaired patients for her doctoral

thesis and is currently responsible for providing pharmaceutical care services in the renal unit at the University Teaching Hospital.

Her other areas of interest include respiratory medicine and paediatric medicine. She is a member of local and national professional

bodies.

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Surgical Prophylaxis of Antibiotics in Orthopedic Procedures

Shubham Babu Gupta*1, Pankaj Wadhwa2 1Department of Pharmacy Practice, Malla Reddy Institute of Pharmaceutical Sciences, India. 2Department of pharmacology, Lovely Professional University, Punjab, India.

Abstract:

Background: Appropriate utilization of antimicrobial specialists is imperatively significant from clinical points. Present

anti-microbial agents are one of very crucial for clinical consideration and assume a significant job profile, both in

prophylaxis and treatment. Not with standing, their abuse is an overall issue with the degree of the issue being more

prominent in the developing nations. Aim: To observe the utilization of antimicrobials for prophylaxis and treatment

among patients who have underwent orthopaedic surgical procedure. Methodology: A Prospective and observational

examination was led on 300 clinical records of orthopaedic patients. Result: It was observed that the most commonly

used antimicrobials classes were cephalosporin’s (76.43%) and cefuroxime (67.40%), for prophylaxis and treatment,

respectively. It was found out 37.67% for prophylaxes were inappropriate whereas around 71.07 % of antibiotics

treatment neglected to hold fast to guidelines. Conclusion: Generally, this investigation includes the maximum numbers

of patients from open reduction internal fixation (ORIF) and total hip replacement surgeries, respectively. The results

of study observed the some degree of inappropriateness to some extent in case of surgical prophylaxis during orthopaedic

procedures.

Keywords: Antibiotics; Surgery; Prophylaxis; Inappropriateness, ORIF.

Biography:

Shubham Babu Gupta is a PharmD graduate, currently perusing Ph.D. from Lovely professional University. He has worked as

Clinical research coordinator, for a year. Presently his working as Assistant Professor in Department of pharmacy practice in Malla

Reddy Institute of Pharmaceutical Sciences, Hyderabad, Telangana. He has 8 research papers so far to his name published in various

National & International Journals; He has also compiled a textbook of Pharmacotherapeutics for PharmD second year. He is also

trained in Pharmacovigilance, clinical Research & Hospital management.

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Preformulation Detailing on Novel Buccal Drug Delivery by use of Effervescent Technology.

K. Pansuriya1*, P. Parejiya2, D. Suthar3, P. Shelat4, A. Vekariya5, H. Patel6

1,2,3,4,6K B Institute of Pharmaceutical Education and Research, India. 5Alembic Pharmaceutical Limited, Vadodara, India.

Abstract:

Candesartan cilexetil is novel, potent and highly selective non peptide angiotensin II type 1 receptor blocker. It is

hydrophobic drug which belongs to BCS Class II drug (Low solubility and High permeability). For enhancement the

bioavability and quick systemic action of candesartan cilexetil a novel formulation of buccal (effervescent) tablet was

designed. To overcome the issues Candesartan cilexetil, buccal tablet was developed using effervescence, as a micro

environmental pH modifying agent which facilitates enhancement of solubility. It evolves CO2 gas which improve

permeability and hence bioavailability, by alteration of epithelial cell junction. Preformulation is an important step in

the rational formulation of an active pharmaceutical ingredient (API). Micromeritics properties: Bulk density (du),

Tapped density (db), Compressibility Index (%C) and sieve analysis was performed in order to determine the best

excipients to be used in the formulation development of Candesartan cilexetil (effervescent) tablets. Results show that

Candesartan Cilexetil has fair flow and compressibility properties (du 0.8 g/mL, db 0.7 g/mL, %C 12.5 and sieve

analysis time 4.5min. HPLC method for estimation of Candesartan cilexetil shows linearity ( R2 = 1) and specific with

no interference of excipients. Solubility studies reveals that it soluble at pH 6.8 and 7.5 in phosphate buffer. The ability

of material to absorb water (Hygroscopicity) was found 0.1% after 24 Hrs at 80% Relative Humidity. Melting point

range from 161-165 °C. There was no any drug excipients interaction was observed when analyzed through FTIR and

DSC. There was no change in appearance after 15days at 40°C and 75% Relative humidity. These all results lead to

the better development of Candesartan cilexetil buccal (effervescent) tablet.

Key words: Candesartan cilexetil, Preformulation, Drug-excipients interaction, Effervescent

Biography:

Ms K Pansuriya is a GPAT rank holder. She completed her Master of Pharmacy from K.B. Institute of Pharmaceutical Education

and Research, Gandhinagar Gujarat, and patented one formulation viz. “Probiotic Effervescent Composition” Patent number:

3533/MUM/2015 A. She Is pursuing a Ph.D. at KBIPER, Gujarat. Associated with the Formulation development department of

Vovantis Laboratories Ltd and Centurion Remedies Ltd.

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The Use of SSRI’s Linked to Violent Crime Conviction?

Aneeta Jeeson*, Bharat Mishra, Namrutha Krishna UR

Nirmala college of pharmacy, India.

Abstract:

Selective serotonin reuptake inhibitors(SSRI) are one of the first line agents used widely for the treatment of depression

and because of their relative safety and better acceptability, they’ve been used extensively in OCD, phobias, panic

disorders, anxiety and other related conditions. Despite their added recognition over other class of antidepressants

drugs, in the recent years, however, they’ve been extensively studied for their role in conviction of violent crimes. In

a study conducted in Sweden during the years 2006-2013, amongst patients who had been taking SSRI’s (from Swedish

national register) belonging to the age group of 15-60 years the outcome was violent crime conviction. The study was

conducted in a total of 785,337 participants with 64.2% females, experienced 32,203 violent crimes in 5,707,293 person

years. The Hazard Ratios that was found to be statistically significant were of the following order HR=1.19(15- 24yrs)

HR=1.16(25-34yrs) and the non-significant data was HR=1.02(35-44yrs) and HR=1.04(45-60yrs) implicating that

people belonging to the age group 15-24 were at an increased risk for developing criminal conviction in comparison

to other age groups. The highest risk period was found to be during the treatment period (HR=1.24 to 1.35) and

continued to be elevated for up to 12 weeks post treatment phase (HR=1.37 to 1.20). More men were convicted than

women (5.7%vs1.0%) although during younger years the ratio was reversed. Further analysis also revealed that the

elevated risk for violent crime convictions were found to be more for people with previous crime records (HR=1.13)

compared to those with no previous criminal records (HR=1.07). The increased risk of violent crimes had not been

made responsible by the drug alone but, it acts as a potentiating factor for people with depression having an intrinsic

tendency to criminality as well as for people who are aggressive and in non- adherent individuals.

Biography:

Aneeta Jeeson, a third year PharmD student from Nirmala College of Pharmacy, Kerala, India, is a student speaker with keen

research interest in Pharmacology and Pharmacotherapeutics where she has shown her sincere dedication and commitment. She has

presented for the World Conference on Epidemiology- Infectious Diseases and Public Health, London, UK. Apart from researches

and studies, Aneeta Jeeson was also an active member in sports and cultural activities during her High School days. Public speaking,

reading and essay writing constitute her special talents.

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Effect of Host Genetics on the Second Genome: The Gut Microbiota

Christy Sojan*, Bharat Mishra, Aan Mery Bosco

Nirmala College of Pharmacy, India.

Abstract:

The various associations of microorganisms and their combined genome found on and within the body comprises the

microbiome which makes vital contributions to the human metabolic and immune functions thereby having a significant

impact on the host health. The gut microbiota therefore can be considered as the second genome of our body. Genetic

variations in the host can lead to alterations in pathogen sensitivity and gut microbiome composition (dysbiosis) which

are being unraveled by genome- wide association studies (GWAS) being conducted. The resulting dysbiosis of the gut

microbiome can lead to an imbalance of the microbe-host homeostasis and cause gastrointestinal disorders such as

Crohn’s disease, ulcerative colitis as well as extra-intestinal disorders such as asthma, obesity, Type II diabetes mellitus,

neurological disturbances and rheumatoid arthritis. From various articles it can be concluded that the existence of a

particular taxa is mainly controlled by the host genetics whereas the environmental and dietary factors are responsible

for the abundance of each taxon. On comparing the studies analysing the faecal microbial communities as obtained from

the human subjects we can arrive at the fact that more similar the genome, more similar will be the membership of the

gut microbial community. However, despite the progress there are challenges which are encountered during the analysis

such as the effect of environment which masks the effect of genetic variants or the increased microbiome structure

complexity. Linking the host genetics and individual microbial composition may help us pave a way for the potential

therapies aimed at modulation of the gut microbiota and personalized medicine.

Biography:

Christy Sojan is currently a 3rd Year PharmD student at Nirmala College of Pharmacy, Kerala, India. She has a keen research interest

in Pharmacology and Pharmacotherapeutics. She was also an active member in sports and cultural activities during her schooling in

Delhi. Public speaking, reading, drawing and essay writing constitute her talents.

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Ministry of AYUSH, Govt of India Recommended Anti-Viral Formulations and Herbs from Siddha

System of Medicine for COVID 19 – A Review

Muralidass S. D.

Siddha Physician, Arumbakkam, India,

Abstract:

The Coronavirus disease (COVID-19) caused by the virus SARS-CoV-2 has become a global pandemic in a short time

has infected about 17,660,523 patients and brought forth death rate about 680,894 among 206 countries as mentioned

by WHO in 2nd August 2020. Currently, there is no specific treatment or vaccine for fighting against this infectious

disease and scientists agree that possible therapeutic may arise through drug repositioning. Herbal medicines are

achieving attention because of the extensive therapeutics like potent anti-viral, immunomodulatory, anti-inflammatory,

and anti-oxidant properties. Ministry of AYUSH, Govt. of India recommended 5 Siddha formulations (Kabasura

kudineer, Nilavembu Kudineer, Vishasura Kudineer, Pavala Parpam and Velli Parpam) and 12 Siddha herbs (Inji –

Zingiber officinale, Thulasi – Ocimum sanctum, Milaku – Piper nigrum, Karunjeeragam – Nigella sativa, Keezhanelli

– Phyllanthus niruri, Adhimathuram – Glycyrrhiza glabra, Vellaippoondu – Allium sativum, Citramutti – Sida

cardifolia, Seenthil – Tinospora cordifolia, Manjal – Curcuma longa, Elumitchai – Citrus limonia and Vembu –

Azadirachta indica) for the prevention by enhancing immunity as well as for the management of this infectious disease

in its recent official publication ‘Guidelines for Siddha Practitioners for COVID 19’. This is the common advisory and

the anti-viral activity of these formulations and herbs against COVID 19 is not established yet. These formulations and

herbs are being prescribed for acute viral and bacterial respiratory diseases and other chronic respiratory diseases in

Siddha System of Medicine from ancient times. So the author made attempt to discuss the literature review and the

review of pharmacological actions of these herbals. The complete review will be discussed in the online presentation of

the conference.

Keywords: COVID-19, SARS-CoV-2, Siddha Medicine, Medicinal plants, AYUSH

Biography:

Dr. S. D. Muralidass had presumed his Under-graduation BSMS (Bachelor of Siddha Medicine and Surgery) at Govt. Siddha

Medical College, Palayamkottai, Tamilnadu in 2009 and Post-graduation M.D (Siddha) in the Dept. of Siddha Special Medicine,

National Institute of Siddha, Chennai, Tamilnadu in 2012. He served as Assistant professor in the Dept. of Siddha Special

Medicine, Santhigiri Siddha Medical College, Trivandrum, Kerala for 3 years from 2012 to 2015, then served as Medical

Consultant and Research Associate in Siddha central Research Institute under Central Council for Research in Siddha (CCRS),

Ministry of AYUSH, Govt of India, Arumbakkam, Chennai, Tamilnadu for 4 Years from 2015 to 2018, after that he served as

Lecturer in the Dept. of Siddhar’s Yogic Science, National Institute of Siddha, Ministry of AYUSH, Govt of India, Tambaram,

Chennai, Tamilnadu for one year 2019 – 2020. Currently he is working as Independent Researcher and full-time clinician in

Chennai. He published 20 articles in National and International level Journals, presented 10 papers in National and International

level Conferences, participated in various Trainings, Workshops, Conferences, Expo, Medical awareness camps and programs.

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Ewing’s Sarcoma’s Inception with Paraplegia: An Unusual Anamnesis

Niveena Varghese1*, Bharat Mishra2, Fida firdouse3, Ashna Joy4 1Kerala university of health sciences, India. 2Nirmala College of pharmacy, Kerala, India. 3,4kuhas university of health sciences, India.

Abstract:

Ewing sarcoma (ES) family of tumour’s includes bone and soft tissue tumour’s that are often delineated by specific

translocation between chromosome 11 and 22, resulting in the EWS-FLI1 fusion gene, where people interpolate with

excruating pain usually spotted in first decade of human’s life expectancy. 80% occurs between ages 5 and 25 which is

mostly discerning white people. Non-sacral spinal Ewing's sarcoma is rarer and often mimics a benign condition before

spreading extensively. Innovative therapies for patients with metastatic or recurrent disease are urgently needed, as

survival remains less than 30%. With the advent of multi-modality treatment including, cytotoxic chemotherapy,

surgery, and radiation therapy, the prognosis for patients with ES has substantially been upgraded. An acute onset of

paraplegia, an impairment in motor or sensory function of the lower extremities is an emanating, further incepted index

to mark this rarest entity. here we would make out a description on unusual inception with paraplegia. Spinal cord

compression can produce neurological deficits depending on tumour location, but is often a delayed presentation.

Rapidly progressing paraplegia is uncommon and a high index of suspicion is essential for diagnosis, especially in a

young patient. We dispatch a rare case of dorsal spine Ewing's sarcoma that presented with acute onset paraplegia and

improved with radical tumour decompression. Ewing's sarcoma often tends to invade the spinal canal from the

paravertebral soft tissue component through the intervertebral foramen, compressing the cord circumferentially. This

makes laminectomy an effective approach for cord decompression. Acute paraplegia as a presenting symptom is

extremely rare in Ewing's sarcoma of the nonsacral spine and requires a high index of suspicion in children for early

diagnosis. An atypical clinical course in a musculoskeletal or neurological condition, that also instil paraplegia that

should alert us to a possible underlying malignant disease.

Biography:

Niveena Varghese, second year PharmD student, hails from India. She lately making an article for publication on topic intervened

with a virus-chlorovirus (highly deadly), and very curious in making a study in pathophysiology of rarest cancers. My keen

perception on these rarest entities, had driven me to a big fascination on aggressive malignant tumours, their signalling pathways,

mechanisms and treatment. I as a pharmacy student have a deep instinct in drug discovery. I have participated in several online

quizzes, dealing with the realm of pharmacognosy and therapeutics and have received several e-certificates. I hope and a have a

great desire to become an industrial pharmacist and explore to its fullest.

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Brain Plasticity in Neuropsychological Disorders: Mechanism and Genetic Interventions

Benita John*, Bharat Mishra

Nirmala college of pharmacy, Kerala University of Health Science, India.

Abstract:

Early researchers believed that neurogenesis had stopped shortly after birth. But currently it is understood that the brain

possesses the remarkable capacity to reorganize pathways, create new connections and create new neurons—a concept

known as neuroplasticity or brain plasticity. The current review considers the impact of genetic factors, the interface

between psychiatry and neurology and molecular mechanism underlying neuronal synaptic plasticity. Synaptic plasticity

is one of the mechanisms that underlies long term memory storage. Long term synaptic plasticity may be subdivided

into long term depression (LTD), in which synaptic strength decreases and long-term potentiation (LTP), in which

synaptic strength increases. The molecular mechanism for memory consolidation is LTP and it correlates with learning.

An important area in which brain plasticity is of considerable interest is recovery from stroke. Stroke is a medical

condition in which poor blood flow to the brain causes cell death. A number of factors influence the poststroke brain

events. Polymorphisms in the human genes coding for brain-derived neurotrophic factor (BDNF) and apolipoprotein E

(ApoE) have been studied in the context of plasticity or stroke recovery. Many disorders are generally produced due to

the disruption of neuronal plasticity. Post-traumatic stress disorder was the first psychiatric disorder associated with

hippocampal atrophy. It is associated with long term changes in Neurobiology. Brain areas involved in the stress

response include the medial prefrontal cortex, hippocampus and amygdala. Neurohormonal systems that act on the brain

areas to modulate PTSD symptoms and memory include glucocorticoids and norepinephrine. Dysfunction of these brain

areas is responsible for the symptoms of PTSD.

Keywords: BDNF, ApoE, PTSD, LTP, LTD

Biography:

Benita John is a student currently pursuing 3rd year PharmD in Nirmala college of Pharmacy, Muvattupuzha affiliated to Kerala

University of Health Science. Her areas of interests are Pharmaceutical Analysis and Pharmacotherapeutics. She has won several

prizes during her school levels and anchored several programmes in school levels.

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Keynote Abstracts

Day-2

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Novel Spiro-Polyketide Svalbardine B from the Arctic Fungal Endophyte Poaceicola Sp:

Extremophiles with A Greater Potential for Drug Discovery

Sadia Sultan*, Fatimah be *Department of Pharmacy, University Technology Mara, Malaysia.

Abstract:

Extremophiles have always been deemed as endowed with a greater potential for drug discovery than microorganisms

from “normal” ecological niches. In this respect, psychrophiles from the Arctic fulfil the criteria of an interesting source

of potential new drugs. Thus, this study included 31 endophytic fungi that were isolated from 8 plants from

Longyearbyen, Svalbard Island, Norway, the objective of this study was to isolate secondary metabolites from

endophytic fungi whose extracts demonstrated antimicrobial properties. Ethyl acetate extracts of all the isolates were

analysed by HPLC and evaluated for preliminary screening of antimicrobial activity against S. aureus, E. faecium, P.

aeruginosa, E. coli, and C. albicans, using the MTT assay. The crude extracts were fractionated, and their components

purified by semi-preparative HPLC. Chemical structures were determined based on spectroscopic methods including

MS, NMR, UV/Vis, ECD and X-ray diffraction techniques. The culture of Poaceicola sp. yielded one known compound

identified as annularin D. Five new polyketides, including (-)-cleanarol C (C13H14O4), (-)-3,8-dihydroxy-3-

hydroxymethyl-6-methoxy-4,5-dimethyl-isochroman-1-one (C13H16O6) and svalbardines A (C16H14O6), B

(C32H28O12) and C (C10H14O4) had their structures established. Svalbardine A was determined as a new

pyranochromene, while svalbardine B was assigned a new carbon skeleton based on a spiro chromone-oxanaphthalene

frame. Svalbardine C was determined as a hydroxylated derivative of annularin D, while the remaining two compounds

were new enantiomers of known structures. Most of the known compounds mentioned above were previously recognised

for their antimicrobial properties and can be regarded as responsible for the overall activity of the crude extracts during

the MTT screening, thus vindicating the initial hypothesis. It is therefore believed that this work could be the basis for

a more targeted search of novel antimicrobials.

Biography:

Dr Sadia Sultan is an Associate Prof in the Department of Pharmacology and Chemistry at the Faculty of Pharmacy, University

Technology MARA (UiTM) Malaysia. She has over 70 research publications in top international journals including high impact

factor journals like European Journal of Medicinal Chemistry, European Journal of Pharmaceutical Chemistry, Journal of Steroids,

Tetrahedron Letters, Bioorganic and Medicinal Chemistry, Journal of Molecules with cumulative impact factor of over 100 and 650

citations, with h index 15.

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Scientific Sessions Abstracts

Session 1& 2 Day 2

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Session 1&2 Day 2-August 27,2020 Pharmacy Practice, Pharmacology, Drug Screening and Discovery, Drug Design and Development, Novel Drug

Delivery System

Title: Making Sense to the First Year Student – The Core Disciplines and Other Auxiliary Subjects in the Pharmacy

Curriculum

Name: Sivaram Hariharan, PSG College of Pharmacy, India

Title: Dilemma and Uncertainty in COVID-19 Treatment: A Reality Check

Name: Bharat Mishra, Nirmala College of Pharmacy, India

Title: Evaluation of Antidiabetic Potential of Traditionally Used Medicinal Plant Cyathea Nilgiriensis (Holttum)

Name: S Elavarasi, Holy Cross College, Bharathidasan University, India

Title: Genetic Traits & Chromosmal Approaches in Anxiety Disorders

Name: Camila A Carlman, Nirmala College of Pharmacy, India

Title: Insulin Signaling and Psychopharmacological Interventions

Name: Elizabeth Rachal James, Nirmala College of Pharmacy, India

Title: Mathematical Models of the Body: Understanding the Drug Diffusion through the Body Compartment of the

Systemic Circulation and Tissue Medium-A Caputo Model

Name: Ramanamoorthy Kandula, B.V. Raju Institute of Technology, India

Title: Formulation and Evaluation of Liposomel Gel of Serratiopettidase

Name: A Rajesh, Andhra University, India

Title: Non –Functional Pancreatic Neuroendocrine Tumor [Nf-Pnet]- An Apperception of Molecular Mechanism

and Genetic Intervention

Name: Anitta Thomas, Nirmala College of Pharmacy, India

Title: Evaluation of Antidiabetic Activity of Polyherbal Chitosan Synthesized Nanoparticles on STZ Induced Diabetic Rat

Model

Name: G Revathi, Nehru Memorial College, Bharathidasan University, India

Title: Role of Molecular Docking in Computer Aided Drug Design

Name: Kushagra Dubey, Smriti College of Pharmaceutical Education, India

Title: Risk of Genotoxic Agents and its Effects on Aging, Sterility and Cancer

Name: Nagashree K S, JSS College of Pharmacy, India

Title: Dissolution Enhancement of Diacerein Using Water Soluble Carrier by Solid Dispersion Technology

Name: D Nagasamy Venkatesh, JSS College of Pharmacy, India

Title: Encephalomyelitis Disseminata: Genesis through Reformation

Name: Fida Firdouse, Nirmala College of Pharmacy, India

Title: An Overview of Trichoepithelioma

Name: Aleena Elsa Jacob, Nirmala College of Pharmacy, India

Title: Overview on Gestional Trophoblastic Tumor

Name: Parvathy B Nair, Nirmala College of Pharmacy, India

Title: Bioprinting: An Advancement in the Cancer Research

Name: Shefin Siby, Nirmala College of Pharmacy, India

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Making Sense to the First Year Student – The Core Disciplines and Other Auxiliary Subjects in the

Pharmacy Curriculum Sivaram Hariharan*, M Ramanathan, V Sankar, Yuvraj S

PSG College of Pharmacy, India.

Abstract:

There has been enough literature in the past as well as in recent times about the different roles of pharmacists in his /her

profession; pharmacy being a multi-disciplinary profession1. It is also a field, which utilizes the best knowledge /

knowhow from different areas of science. Unfortunately, little has been done in the area of how these various disciplines

interact with each other in the greater context of the profession. Entry level pharmacy students as well as pre-entry

students are bombarded with a variety of subjects during their course without explaining to them as to how these courses

relate to each other. Also, not explained are keywords that define a particular area within the pharmacy profession. The

purpose of this article is to serve as a teaching tool to First Year B Pharmacy students as well as to elucidate the way

the different disciplines such as Pharmaceutics, Pharmaceutical Chemistry, etc., interact and also the keywords that

define these areas; with the objective of giving a clear picture of the profession to entry level and aspiring pharmacy

students and maybe even to those outside the profession. Regardless, this commentary is solely aimed as a teaching aid

to First Year Pharmacy (freshmen) and pre-entry students and looks at this issue firmly from their point of view.

Biography:

Dr Sivaram Hariharan is a Professor of Pharma Chemistry at PSG College of Pharmacy. His research interests are in the field of

Pharma Chemistry as well as Pharma Education and has interests in certain legal aspects of the profession, especially Patenting

concerning Pharma Research. He has publications in reputed journals and has also published an article in Nature Asia. Dr Sivaram

is also a prolific writer of fiction with works to his credit that have been well received by readers. His books are listed on Amazon

and Goodreads.

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Dilemma and Uncertainty in Covid-19 Treatment: A Reality Check

Bharat Mishra,

Department of pharmacology, Research & Development Cell, Nirmala College of Pharmacy, India.

Abstract:

In December 2019, a severe outbreak of a novel coronavirus (COVID-19) occurred in the whole world. With the

development of the epidemic, there is an urgent need to improve the cure rate to find effective drugs against this virus.

Chloroquine (CQ) and Hydroxychloroquine (HCQ) was verified as potential candidates for treating COVID-19. The

serious conflicts and dilemmas have been observed from the reports and statements from authority to authority and

country to country about the suitable and most appropriate treatment options available in the current time. The most

significant conflict has been noticed over the effectiveness and suitability of the uses of HCQ in COVID -19 treatment.

The WHO has recommended the controlled use of HCQ initially but recommended to discontinue the usage on the basis

of a single published article by LANCET later. The great numbers of scientists from all over the world have made the

LANCET to retract that paper and so to WHO to revert their statement. Even the ICMR, UK and USA authorities have

their own stands on HCQ, Remdesivir, Dexamethasone and other antiviral drugs in the treatment of Covid-19. The

content for this review have been searched with the PubMed, EMBASE, Springer, and science direct databases as well

as the current reports, press conferences, and statements of authorities from WHO, ICMR, and the ministry of health

from the UK and the USA. It is been found that the potential preclinical or clinical evidences are there for using CQ and

HCQ against COVID-19. The COVID-19 turning to its aggressive phase of spreading, the treatment options where less

and several options are trialing and seeking. Convalescent plasma therapy is one of the newest trailing therapies for

COVID patients today without other definite treatment, but the continuity and effectiveness is still a question to find the

answer. There are a number of clinical studies are presenting the data in support or in against of the usage of the HCQ

and other antiviral drugs in COVID-19 treatment but all have used the small number of subjects so the world is still

waiting to know the availability of the sure-shot vaccine as well as the answer on the fate of the HCQ and other antiviral

drugs in the treatment of COVID-19 by acceptable and significant clinical studies.

Biography:

Dr. Bharath Mishra having more than 15 years of teaching experience in pharmaceutical education with proficiency in preclinical

research, toxicological research, animal house maintenance, handling sophisticated instrument, pharmacological screening models

and their modifications, scientific writing, and molecular cell signaling mechanisms. He published 42 quality research articles and

conference proceedings in international and national journals, books & international book chapters in CRC press: Taylor & Francis

Group, USA & Nova Science Publishers, inc.-USA. He honored to have the publications in journals of repute as Dove Medical

Press Ltd, Auckland, New Zealand, Kidney and Blood Pressure Research & Renal Failure. He awarded for ‘Excellence in Research’

by 5th South Asian Education Awards-2020-EET CRS Research wing for excellence in professional education & Industry. Currently

working as the Professor & Head, Department of pharmacology and Research & Development Cell, Nirmala College of Pharmacy,

Muvattupuzha, Kerala, India.

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Evaluation of Antidiabetic Potential of Traditionally used Medicinal Plant Cyathea Nilgiriensis

(Holttum)

Elavarasi. S1*, Revathi. G2, Saravanan. K3 and Horne Iona Averal4 1,4PG and Research Department of Zoology, Holy Cross College (Autonomous), India. 2,3PG and Research Department of Zoology, Nehru Memorial College (Autonomous), India.

Abstract:

Diabetes mellitus is a non-communicable disease, which is considered as one of the five leading causes of death in the

world. Traditional natural medicines are used throughout the world for a range of diabetes. Ethnobotanical investigation

revealed that Cyathea nilgiriensis was popular among the traditional healers to treat diabetes. Toxicity of the aqueous

extract of C. nilgiriensis pith powder showed no abnormal effect on the behavior of rats and did not cause mortality.

Blood glucose level was maintained near to normal state in aqueous extract of the drug treated diabetic rats. Reduced

levels of insulin, HbA1C and liver glycogen were restored and increased levels of renal profile of diabetic rats were

reduced to normal level. Elevated levels of liver marker enzymes were reduced and maintained near to normal level in

aqueous extract of C. nilgiriensis treated diabetic rats. Extract treatment has restored the LDL and VLDL levels.

Decreased HDL level was observed in diabetic rats and was increased by the treatment with aqueous extract of the drug.

The treatment of diabetic rats with herbal extract increased the levels of antioxidant and was well improved in the

antioxidant defense system. Histopathological study of the experimental rats treated with test herbal drug and

glibenclamide restored the tissue damages of diabetic rats. Docking studies of the ligand obtained from the extract

showed that the compounds such as 11 beta hydroxysteroid dehydrogenase and Protein tyrosine phosphatase 1 beta are

good molecules which dock well with the targets. From the above experimental responses, it is concluded that the C.

nilgiriensis prove that it is one of the best promising and emerging drug against diabetes mellitus and its complications.

Keywords: Cyathea nilgiriensis, Ethnobotanical study, Molecular Docking, Antidiabetic activity

Biography:

Dr S. Elavarasi, PhD, is an Assistant Professor of Zoology at Holy Cross College (Autonomous), an affiliated Institution of

Bharathidasan University, Tiruchirappalli, Tamilnadu, India. Elavarasi has been engaged in teaching and research for more than

eight years. Awarded an NTS-PhD fellowship–2010 by the Central Institute Indian Languages, Mysore, Karnataka, India, for

pursuing her PhD degree and National Post-Doctoral Fellowship–2017 by SERB-DST, New Delhi, India. Elavarasi collaboratively

worked and published 26 research articles and 3 book chapters in various fields of Life Sciences. The field of specialization in

research of Dr. S. Elavarasi is herbal technology, drug designing and biodiversity conservation.

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Genetic Traits & Chromosmal Approaches in Anxiety Disorders

Camila A Carlman*, Bharat Mishra

Nirmala College of Pharmacy, Kerala University of Health & Science, India.

Abstract:

Anxiety Disorders are complex disorders which can be derived from a combination of genetic and environmental factors.

Anxiety disorder (AD) includes generalized anxiety disorder (GAD), Panic disorder (PD) & Phobias. According to

demographics, ADs are the most common mental disorder with prevalence estimated as 19.3% in USA. Anxiety is

showing genetic correlation with depression & insomnia, CAD as per the epidemiological studies. The most vulnerable

gene involved in AD is Serotonin transporter gene and it is highlighting the pleiotropic hypothesis regarding anxiety.

Recently in 2017, studies concluded that GAD can be inherited and other associated conditions are linked to various

genes. The 5-HT2A & T102C polymorphism has a role in development of SAD. Since oxytocin stimulates neurons

expressing oxytocin receptors, it controls multiple physiologic functions. Hence OXT play partial role in modifying the

stress response and stress-related behaviours which may lead to anxiety condition. European studies suggest that

inherited variation in catecholamine metabolism is also important in pathology of anxiety disorder especially in women.

The frequency of greater than 3 repeat alleles of the MAO-A gene polymorphism was higher in females. The intronic

rs1709393 minor C allele on chromosomal band 3q12.3 of an uncharacterised non-coding RNA locus is associated with

lifetime diagnosis of AD. Studies also revealed a significant intronic hit for rs35855737 minor C allele on chromosome

3q14.1. The frequency of less active serotonin transporter polymorphic region S/S genotype is higher in patient with

GAD. The patients with bipolar disorder showed higher frequency of COMT Met 158 genotypes. Anxiety disorders are

highly complex and polygenic. The susceptibility risk of anxiety disorders has been explained by differential inherited

and acquired genetic trait.

Biography:

Camila.A. Carlman is a third year Pharm-D student at Nirmala College of Pharmacy, Muvattupuzha, India, affiliated to Kerala

University of Health & Science. She has attended relevant conferences which were held at national and international levels and

presented her papers. Her recent activities include working on various papers with her professors and publishing several articles in

popular journals. Her article on COVID-19 was very applicable to the current situation worldwide. She is interested in

extracurricular activities. She is talented in public speaking and has participated in a national level debate contest held in 2019. She

is aspiring to be a researcher in future.

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Insulin Signaling and Psychopharmacological Interventions

Elizabeth Rachal James*, Bharat Mishra, Dona Basil, Anjana Raj, Aleena Binoy

Kerala University of Health and Science, India.

Abstract:

Insulin is a peptide hormone produced by pancreatic β cells of Islets of Langerhans in response to elevated levels of

glucose in blood. Insulin promote the uptake of glucose, fatty acids and amino acids into liver, adipose tissue and

muscles and assist the storage of glucose in the form of glycogen, lipids, and proteins respectively. When high level of

glucose enters blood stream, insulin is released by β cells of pancreas. Insulin then initiates a number of signal pathways

in specific muscle and fat cells. This review takes an overview at insulin signaling pathway and various defects or

disorder caused by damage at various steps of insulin signaling pathway. Insulin signaling is initiated by binding the

insulin to its receptor and by activation of its cell surface receptor and thereby initiates a cascade of phosphorylation,

de-phosphorylation events, second messenger generation, protein-protein interaction that results in diverse metabolic

events in almost every tissues. Insulin signaling plays major role in neural growth, synaptic development, and control

of neurotransmitter release. The main cause of insulin resistance is impaired or reduced signal transmission. Altered or

impaired insulin signaling leads to various consequences like nervous system dysfunction like neuropathy, psychiatric

illnesses like major depressive disorder (MDD), dementia, schizophrenia, etc.., mood disorders. This focus on the

pathway of insulin signaling and its psychopharmacological interventions.

Biography:

Elizabeth Rachal James, a second year Pharm.D student from Nirmala College of Pharmacy, Kerala, India, is a student speaker

with interest in research field. She was a co- author for an e- poster presentation which was done for National Conference: A

Paradigm Shift for Emerging Paraphernalia in Advancement of Cancer Research, Nirmala College of Pharmacy, Kerala, India.

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Mathematical Models of the Body: Understanding the Drug Diffusion Through the Body

Compartment of the Systemic Circulation and Tissue Medium-A Caputo Model

Ramanamoorthy Kandula1*, Rupali S. Jain2, Sandhya Kandula3, B. Surendranath Reddy4

1Department of Mathematics, B.V. Raju Institute of Technology, India. 2,4Department of Mathematics, Swami Ramanand Teerth Marathwada University, India. 3Department of Pharmacology, Vishnu Institute of Pharmaceutical Education and Research, India.

Abstract:

This study aims to provide an overview of various models to study drug diffusion into and within the human body. We

emphasized the mathematical compartment models using fractional derivative (A Caputo model) approach to investigate

the change in drug concentration in different compartments of the human body system through the oral route or the

intravenous route. Law of mass action, first-order kinetics, and Fick's perfusion principle used to develop mathematical

compartment models representing drug diffusion throughout the human body. To adequately predict the drug diffusion

into various compartments of the human body, we consider fractional derivative (A Caputo model) to investigate the

rate of concentration changing depending upon the change in the order of fractional differentiation in all the possible

compartments of the body, i.e., systemic circulation and tissue compartments. We assigned a numerical parameter value

to the rate of constants in different compartments to estimate the drug concentration. Results calculated and figures

depicted by using MATLAB software (version R2020a). We illustrated graphical effects of change in concentration by

assuming various intermediate values according to the fractional derivative (A Caputo model). Resultant graphical

representation concludes that considering the order of differential equation values, the drug concentration varies

depending upon its rate of constants in compartments concerning time. Whereas Model I indicate body as a whole

compartment, model II indicates systemic blood and tissue; and model III considers arterial blood, tissue, and venous

blood.

Biography:

Mr. Ramanamoorthy Kandula working as an Assistant Professor in the department of mathematics at B.V. Raju Institute of

Technology, Narsapur, Medak Dist. Telangana, India. He completed his M.Sc [Mathematics] in 2003 from Osmania University,

Hyd, then he started his career as a Mathematics Lecturer. he also completed M.Phil. [Mathematics]in 2001and B.Ed [Maths with

Physical Sciences]in 2010, presently Mr. Ramamoorthy pursuing Ph.D. in Mathematics [Mathematical modeling of PK/PD/PBPK]

from Swami Ramanand Teerth Marathwada University, Nanded. Under the guidance of Dr. Rupali S.Jain madam. Mr.

Ramanamoorthy has more than 16 years of teaching experience at various levels like B.Sc., M.Sc., M.C.A., and Engineering courses.

he taught different mathematics branches in his teaching experience.

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Formulation and Evaluation of Liposomel Gel of Serratiopettidase

A Rajesh, Andhra University, India Abstract:

The major objective of this study was to develop stable liposomes with high entrapment efficiency. In this work the

influence of formulation parameters on rheological measurements, spreadability and in vitro drug release of various

formulations are studied and To investigate the effect of lipids and the concentration of lipids in the formulation To

determine entrapment efficiency, size and size distribution of serratiapeptidase.

Preparation of Liposomes

Conventional Lipid Film Hydration Technique: The solution was evaporated at a temperature of 250˚C and speed of

150 rpm in rotary evaporator. The drug concentration was 0.1mg/mg of total lipid and the total lipid in 1 ml of liposomal

dispersion was 10mg.

Preparation of Liposomal Gels: The gel was prepared using carbopol 934.

Evaluation Tests:

Standard Calibration Curve: Stock Solution, respective dilutions are prepared such as 20µg/ml to 100µg/ml and the

absorbance values were noted by using UV-Visible spectrophotometer with the wavelength of 270nm.

Entrapment Efficiency: The prepared liposomal formulations were centifuged at 20,000rpm at 4˚C twice for 30min

with 10min interval to separate free drug from entrapped drug.

Particle Size Distribution: Vesicle size distribution was determined using laser diffraction at 25o C, 45mm focus lens,

2.4mm beam length.

Summary and Conclusion:

The results of present study showed that major characteristics of the liposomes and liposomal gels like entrapment

efficiency and rheological measurements, spreadability, invitro drug release respectively were influenced by the use of

various quantities of excipients. These by their composition are best suited for drug delivery through skin for both topical

and systemic action. The main objective of the study was to develop liposomes with high entrapment efficiency. The

entrapment efficiency was found to be high in formulations containing high concentration of lipids. The spreadability

of the formulation with less amount of cholesterol and soyalecithin was found to be more.

References:

1. T. M. Allen and P. R. Cullis, “Liposomal drug delivery systems:

from concept to clinical applications,” Advanced Drug Delivery

Reviews.

2. J. M. Metselaar and G. Storm, “Liposomes in the treatment of

inflammatory disorders,” Expert Opinion on Drug Delivery.

Biography:

Mr. Akkena Rajesh, PharmD is a Post Baccularate from Andhra University.

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Non –Functional Pancreatic Neuroendocrine Tumor [Nf-Pnet]- an Apperception of Molecular

Mechanism and Genetic Intervention

AnittaThomas*1, Bharat Mishra2, Elza Baby3, Annamol Joshy4, Sijin Biju5,

Nirmala College of Pharmacy, India

Abstract:

Non-Functional Pancreatic neuroendocrine tumors (NF-PNETs) are a rare heterogeneous group of neoplasms that are

slow growing and remain asymptomatic, but aggressive and may become incurable once they progress to unresectable

metastatic disease. These are generally sporadic but can also arise in association with genetic syndromes such as

Multiple Endocrine Neoplasia Type-1 (MEN-1), tuberous sclerosis complex (TSC), von Hippel-Lindau (VHL), etc.

These indolent, asymptomatic tumours are typically diagnosed once the tumour gets advanced or from imaging studies

performed for unrelated conditions. Understanding the genetic susceptibility and molecular mechanism are essential to

provide genetic counseling and best preventive care. In diagnosis, the neuroendocrine phenotype is proven by the

immunohistochemical detection of the neuroendocrine markers synaptophysin and / or chromogranin A (Cg A) and

usually characterized by germline or somatic mutations involving MEN-1, TSC1/2, ATRX and DAXX genes. The

pathogenesis of sporadic PNETs occurs by the loss of chromosome 1, 3p, 6q, 11q, 17q, 22q and gain of chromosomes

4q or 9q. Epigenetic modifications and differential microRNA expression are involved in the dysregulated signaling

pathway of PNETs. Aggressive surgical intervention, including formal pancreatic resection and /or resection of

metastases, radiofrequency ablation (symptomatic relief) is associated with improved survival. This overview provides

a comprehensive aspect of molecular and genetic intervention of Non-Functional Pancreatic neuroendocrine tumors.

Key words: Nonfunctional, Sporadic, MEN1, Chromoganin A.

Biography:

Anitta Thomas,fourth year Bpharm student of Nirmala College of Pharmacy, Kerala ,India affiliated to Kerala University of

Health Science.She is a student with keen interest in research and drug discovery.She participated on many online quizes on

therapeutics and have received several e-certificates.Apart from academics,she has active participation in cultural activities and

have won many prizes.

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Evaluation of Antidiabetic Activity of Polyherbal Chitosan Synthesized Nanoparticles on STZ

Induced Diabetic Rat Model

Revathi.G1*, Elavarasi.S2, and Saravanan.K3

1,3PG and Research Department of Zoology, Nehru Memorial College (Autonomous), India. 2PG and Research Department of Zoology, Holy Cross College (Autonomous), India.

Abstract:

Diabetes is a chronic disease affecting millions of people worldwide. Although oral hypoglycemic agents are the

mainstay of treatment of diabetes and are effective in controlling hyperglycemia, they have prominent side effects and

fail to significantly alter the course of diabetic complication. Medicinal plants are used throughout the world for diabetic

treatment. Present investigation of such medicines might offer a natural key to unlock a diabetic patient’s pharmacy for

the future. The present study attempts (Andrographis paniculata, Andrographis alata, Adhatoda zeylanica, Gymnema

sylvestre, Syzygium cumini and Justicia glabra) to determine the toxic effect and antidiabetic effect of polyherbal drug

extracts on male albino rats (Rattus norvegicus). Polyherbal drug extracts showed no behavior changes of rats and

mortality. Polyherbal extract loaded chitosan nanoparticles were synthesized by ionic gelation method and

characterized. From the experimental results of antidiabetic evaluation, it is concluded that drug loaded chitosan

nanoparticles could be used as an ideal carrier to deliver polyherbal drug to the specific targets and the data obtained

from this study indicates that the ethanol extract of the polyherbal drug is capable of exhibiting significant antidiabetic,

hepatoprotective, antihyperlipidemic and antioxidant activities. The results of the present investigation concluded that

the ethanol extract of polyherbal drug prove that they are one of the best promising and emerging drugs against diabetes

mellitus and its complications.

Key words: Polyherbal plants, Toxicity, Biochemical parameters, Chitosan nanoparticle, Antidiabetic activity.

Biography:

Dr G. Revathi, PhD., is an Assistant Professor of Zoology at Nehru Memorial College (Autonomous), an affiliated institution of

Bharathidasan University, Tiruchirappalli, Tamilnadu, India. Dr G. Revathi is engaged in research for more than 7 years and has

teaching experience for more than four years. She was awarded a PhD fellowship–2014 in the Ministry of Higher Education, Govt.

of Tamilnadu, Chennai for pursuing a PhD degree. Revathi has published 12 research articles and a book chapter in various fields

of Life Sciences. The field of specialization of Dr. G. Revathi is herbal remedies, especially in Diabetology and antiulcer activity,

and has a keen interest in drug designing and biodiversity conservation.

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Role of Molecular Docking in Computer Aided Drug Design

Kushagra Dubey

Department of Pharmaceutical Chemistry, Smriti College of Pharmaceutical Education, India

Abstract:

Drug design, also known as rational drug design, is the innovative process of finding new medications based on the

knowledge of a biological target. The drug is a small molecule that activates or inhibits the function of a target protein,

which in turn results in a therapeutic benefit to the patient. Drug design involves the design of molecules that are similar

in shape to the biomolecular target with which they interact and therefore will bind to it. This type of modelling is

sometimes referred to as computer-aided drug design. Molecular Docking is widely used in CADD (Computer-Aided

Drug Designing). Docking is a method which predicts the preferred orientation of one molecule to a second when

bound to each other to form a stable complex, which in turn may be used to predict the strength of association or

binding affinity between two molecules. using, for example, scoring functions.

Biography:

Dr. Kushagra Dubey, Ph.D. currently working as an Associate Professor in Smriti College of Pharmaceutical Education, Indore

India She did B. Pharm in 2002 from Rajiv Gandhi Technical University & M. Pharm in Pharmaceutical Chemistry from School

of Pharmacy (SOP), University Department, Devi Ahilya Vishwavidyalaya, Indore in 2009 and Ph.D. from Dr.A.P.J. Abdul Kalam

University Indore in July 2020. she had a total of 14 years of academic and 10 years of research experience. she develops innovative

teaching practices and assessments for the evaluation in teaching, research, and training. She is a Registered Pharmacist in State

Pharmacy Council, [M.P.], and is a Life member of APTI (Association of Pharmaceutical Teachers of India). She has coordinated

number sponsored academic, scientific, and technical events. She was Co-coordinator of DST-INSPIRE Science Camp in 2018

and 19 at Smriti College of Pharmaceutical Education, Indore, a grant of Rs. 13,00,000/ in each session.

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Risk of Genotoxic Agents and Its Effects on Aging, Sterility and Cancer

Nagashree.K.S.*, Rajini Kolure, Malaika Solomon, Manjula.S.N.

Department of Pharmacology, JSS College of Pharmacy (JSS Academy of Higher Education& Research), India.

Abstract:

Genotoxicity is the ability of a substance/agent to produce an adverse impact on Deoxyribonucleic Acid (DNA),

Ribonucleic Acid (RNA), which therefore affects their reliability. Genotoxic potential of modern drugs is evaluated for

its safety and efficacy by regulatory authorities all over the world as a part of evaluation process. Genetic toxicity is an

important component for safety analysis of industrial chemicals, agricultural chemicals, pharmaceuticals, food additives,

colorants and chemicals. In New Drug Application (NDA) process for evaluating the risk and benefits of new chemical

entities (NCE), Pre-clinical studies are needed to get data on toxicological profile i.e., safety and efficacy of the NCE.

Thus, genotoxic tests are fundamental regulatory requirements. Drug genotoxic profile required by European and United

States regulatory authorities are now mandatory in India. The present scenario clearly explains the need for conducting

toxicity studies for medicinal herbs and chemicals used by mankind in any other means. In vivo and In vitro genotoxicity

tests provide information regarding a compounds potential mutagenicity and carcinogenicity, as well as reveal the

molecular mechanism underlying the chemicals genotoxic and carcinogenic effects, identify hazards in risk assessment

within molecular epidemiologic research with regards to occupational and environmental chemicals, determine toxicity

profiles of chemicals. The development of genetic toxicology began in the midst of increasing awareness of human

exposure to toxic chemicals in the environment due to modernization of life. Genetic material damage in somatic cells

causes aging, cardiovascular diseases and cancer, whereas in germ cells causes sterility, multifactorial diseases such as

diabetes, psychoses and cardiovascular diseases. It also leads to genetic diseases, such as, sickle cell anaemia,

haemophilia and cystic fibrosis. Here we are going to discuss about the effect of genotoxic agents on germ cells, somatic

cells and the mechanisms involved in causing aging, sterility and cancer.

Biography:

Dr. Nagashree K S Currently working as a Faculty at JSS College of Pharmacy, Mysore. She also possesses Industrial experience

for 4 years where she excelled her research experience where she carried out more than 30 projects in the fallowing areas Toxicity

and Genotoxicity studies: Acute, Sub acute, chronic toxicity according to OECD Guidelines and GLP Standards and Chromosomal

aberration test: Method, different type of aberrations, scoring, Micronucleus assay: Method, scoring according OECD Guidelines ,

Antiobesity studies: High fat diet model PCOS: Estradiol valerate, DHEA induced models, and Letrazole models Analgesic

activity: Peripheral: Writhing test, Central: Eddy’s hot plate Diabetic wound model: Excision and Incision wound model.

Hepatoprotective studies: CCL4 induced Cataract studies: Naphthalene induced

Diabetes mellitus: Design, synthesis, and biological evaluation of novel PPAR-γ modulators as antidiabetic agents.

She was part of preclinical and clinical studies of marketed product Slimferin TM developed at Vidya herbs Pvt.LTD.

In her account she has more than 10 publications in a peer viewed journal

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Dissolution Enhancement of Diacerein Using Water Soluble Carrier by Solid Dispersion

Technology

D. Nagasamy Venkatesh

JSS College of Pharmacy, India.

Abstract:

Diacerein is used for the treatment of osteoarthritis. The drug is practically insoluble in water and exhibits slow

and intrinsic dissolution results in poor bioavailability. In the present investigation, diacerein and β-Cyclodextrin

solid dispersions were prepared to study the influence of β-Cyclodextin on the solubility and dissolution rate of

this poorly aqueous soluble drug. Phase solubility study indicated that solubility of drug increased with increase

in the presence of β-Cyclodextrin indicating a stability constant of 339.66 M-1. Effect of process variables such

as drug to carrier ratio was systematically investigated. Physical characterisation of the solid dispersion were

carried out by various techniques such as Fourier Transform Infrared Spectroscopy (FTIR), differential

scanning calorimetry (DSC) and X-ray diffraction studies (XRD). These studies revealed that a distinct loss of

crystalline nature of the drug in the solid dispersion holds the responsibility in increasing the solubility in distilled

water containing 0.1% Tween 80. The scanning electron microscopy studies revealed that the binary mixtures are

appeared as agglomerates and exhibiting homogenous solid phase could be attributed for enhanced dissolution

rate in comparison with pure drug. The release of drug from the solid dispersion exhibited first order kinetics.

Solid dispersion of diacerein showed a 7.66 times fold increase in dissolution rate over the pure drug.

Biography:

Dr. D. Nagasamy Venkatesh is working as Assistant Professor at Department of Pharmaceutics, JSS College of Pharmacy,

Udhagamandalam. India. Dr. D. Nagasamy Venkatesh is interested in developing certain nano-based drug delivery systems for

antiviral and anticancer drugs. His research is also extended in developing oral sustained/controlled drug delivery systems for certain

drugs of therapeutic interest and analytical and bio-analytical method development for such drugs. He serves as a reviewer of more

than 25 peer reviewed journals including AAPS, Carbohydrate polymer, Indian Journal of Pharmaceutical Sciences. He has authored

more than 50 peer-reviewed publications. He has received three best awards for his presentations/publications in national and

international level conferences.

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Encephalomyelitis Disseminata: Genesis Through Reformation

Fida Firdouse*, Bharat Mishra


Abstract:

Acute disseminated encephalomyelitis (ADEM) is depicted by a brief but world attack of inflammation in the brain and

spinal cord that destructs myelin. Multiple sclerosis is a lifelong inflammatory and neurodegenerative disease influenced

by multiple lifestyle-based factors. The symptoms of ADEM appear promptly, onset with encephalitis and in the

ultimate rigorous cases, seizures and coma. ADEM typically destructs white matter leading to neurological symptoms

such as visual loss, weakness to the point of paralysis, difficulty coordinating voluntary muscle movements. Treatment

for ADEM is targeted at suppressing inflammation in the brain using anti-inflammatory drugs. Lifestyle and

environmental factors potently impact the risk of multiple sclerosis. Genetic predisposition only explains a fraction of

the risk increase. We provide a review of the effects of modifiable risk factors that are identified as being associated

with the risk to develop MS. Evidence supports the use of non –drug therapies in the management of people with MS.

The emerging data concerning the beneficial effects of diet modification and exercises are beyond reviewed. Few

multimodal behavioural interventions have been conducted for people with MS. This study assessed adoption and

adherence to healthy lifestyle behaviours. Genetic susceptibility analyse clustering of MS cases within families, the

variation in MS risk with migration can be interpreted only by changes in environment. Longitudinal studies completed

regarding assessment of vitamin D intake from diet and the risk of MS was set up to 30% lower among women

Depression is the most common co-morbidity for people with Multiple sclerosis. The results provide evidence that

lifestyle risk factor modification is feasible and sustainable over time. The goal is vigilant management to upgrade

quality of life and promote realistic expectations and hope.

Biography:

Fida Firdouse is a second year PharmD student from Nirmala College of Pharmacy, Kerala, India, is a student speaker. She is a

student interested in extracurricular activities as well as in academics during her school days as well as in college days.

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An Overview of Trichoepithelioma

Aleena Elsa Jacob*, Bharat Mishra, Pooja Raj AB

Kerala University of health and sciences, India.

Abstract:

Trichoepithelioma is an uncommon condition in which a single lesion or multiple benign hair follicle tumours (harmless

skin growths) arise on the face after puberty. The tumour cells from rudimentary hair follicles but do not form actual

hair shafts. This disease is mostly seen in the scalp, nose, forehead and upper lip. These lesions originate from benign

proliferation of epithelial- mesenchymal origin cells. Microscopic (histologic) description tells us that basaloid cells

(like cylindroma) that form primitive hair follicle-germ structures with fibromyxoid stroma. Cells are often in fronds,

may have papillary mesenchymal bodies. Young to middle-aged females are most affected. The gene for hereditary

basal cell carcinoma is being located at aq-q31. PTCH and allelic deletions of the PTCH genes are found in hereditary

basal cell carcinoma. The PTCH locus is potentially involved in the pathogenesis of trichoepithelioma. The tumours are

small (usually less than one centimetre), firm, rounded and shiny. They may be yellow, pink, brown or bluish. They

gradually increase in number with age, occurring on both cheeks, eyelids and around the nose. Definitive diagnosis

relies on shave biopsy or excision followed by gross pathological examination and immune histochemistry. If multiple

nodules are present, if the patient is very young, or if family history reveals multiple family members with nodules,

genetic testing is indicated. Trichoepithelioma is histologically similar to basal cell carcinoma and has a rare risk of

malignant transformation. In addition, most frequent incidence of this disease in young to elderly women may lead to

social and psychological issues.

Biography:

Aleena Elsa Jacob, a second year Pharm. D student from Nirmala College of Pharmacy, Kerala, India, is a speaker with keen interest

in Research field especially in pharmacology and pharmacotherapeutics where she has shown sincere interest and dedication. She

was a co- author in e-poster presentation in National Conference : A Paradigm Shift For Emerging Paraphernalia in Advancement

of Cancer Research ,Nirmala College of Pharmacy , Kerala ,India Apart from studies and researcher , Aleena Elsa Jacob was an

active student in cultural activities and public speaking.

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Overview on Gestional Trophoblastic Tumor

Parvathy B Nair*, Bharat Mishra, Amy Thankachan


Abstract:

Gestational Trophoblastic Tumor(GTT) which is also known as Gestational Trophoblastic disease(GTD) which is a rare

disease that can occur after conception, it may occur as a spectrum of tumor or tumor like condition .GTD arise due to

the abnormal proliferation of trophoblastic tissue in uterus, eventhough GTD mainly occur due to elevation of human

chorionic gonadotrophin. There are different types of GTD, it may include Invasive mole, Hydatidiform mole divided

into two complete hydatidiform mole and partial hydatidiform, it is most common type of GTD seen in women,

Choriocarcinoma (malignant form of GTD) ,Placental-site trophoblastic tumor(PSTT) and Epitheloid trophoblastic

tumor(ETT). Most of the GTD are benign(80%) but some are malignant (20%). The symptoms of GTD are viginal

bleeding during or after pregnancy, prune juice, abdominal pain,ovarian pain, nausea and vomiting during pregnancy,

high blood pressure at early stage of pregnancy, it also include severe headache, anemia, sleep problems, unexpected

weight loss, uterus enlargement .It also have risk factors like previous molar pregnancy ,high animal fat diet, blood

type, environmental toxins, high alcoholic consumption etc.GTD can be diagnosis by MRI,CT-scan, ultrasound, human

chorionic gonadotrophin level, examination of placenta, test of spinal fluid, chest X-ray,position emission

tomography(PET) scan. However GTD can be cured by various treatment such as chemotheraphy ,radiation theraphy

and specifically surgery is used to remove the tumor.The surgery used are dilation and curettage and hysterectomy or

combination of these method are used to treat GTD. The treatment depend on the stage of the disease.The incidence of

GTT varies greatly between different part of the world.

Biography:

Parvathy B Nair, a second year Pharm D student from Nirmala College of Pharmacy, Kerala, India. As she is a upcoming student

speaker with keen interest in reaserach field especially in pharmacology and pharmacotherapeutics.She was e-poster presenter in

National Conference: A Paradigam Shift For Emerging Paraphernalia in Advancement of Cancer Research held in Nirmala College

of Pharmacy .Apart from studies and research ,Parvathy B Nair was active in cultural activites and participated in IIMUN(Indian

International Model United Nations).

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Bioprinting: An Advancement 1n the Cancer Research

Shefin Siby*, Bharat Mishra

Nirmala College of Pharmacy, Kerala university of health and sciences, India

Abstract:

Cancer, the big threat to human population globally has been reported to increase the mortality rate. Even when the

pharmaceutical industry has made relevant improvements in cancer therapy over the last decade, it still remains as a

challenge to develop anti-cancer drugs and clinical practices effectively.2D cell culture models used to develop

understanding of the disease but they often failed to accurately replicate human behaviours. Hence, 3D bioprinting, a

technology which has the potential to mimic the in vivo microenvironment with high accuracy has been invented.

Bioprinting is a manufacturing process where the biomaterials like cells and factors that promote growth are compiled

to create living tissue that imitates natural tissue. This technology uses bio ink which create structures in layer by layer

method. These find a vital role in tissue replacement and cosmetic surgeries. It involves pre-bioprinting, bioprinting and

post-bioprinting. The printing techniques include inkjet, extrusion or laser. This advancement contributes significantly

in the medical field of tissue engineering by promoting for research to be done on innovative materials called bio

materials. Bioprinting aims to print organs like heart, liver, lungs etc. in order to test new drugs directly and perhaps

eliminating the need for testing in animals. It fills the gap for the need of donor organs. Overall, bioprinting is gaining

a wide scope in the field of medicine due to its potentiality to produce complex organs and tissues.

Biography:

Shefin Siby, a second year PharmD student, hails from India .an active participant in all extracurricular activities. She is a good

orator too. She has participated in several online quizzes and received e-certificates. lately a seminar, a paradigm shift for emerging

paraphernalia in advancement in cancer research, an international conference, were he was held as speaker. She has keen interest in

pharmacy realm.

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Index

A

Anuja Kammari 8

Angelin Jaimon Augustine 15

Aneeta Jeeson 19

Akkena Rajesh 34

Anitta Thomas 35

Aleena Elsa Jacob 41

B

Benita John 23

Bharat Mishra 29

C Christy Sojan 20

Camila A Carlman 31

D D Nagasamy Venkatesh 39

E

Erumalla Venkatanagaraju 10

Elizabeth Rachal James 32

F

Fida Firdouse 40

G

G Revathi 36

J

Jeet Gandhi 11

Jiwa Elizabeth Sabu 14

K K Pansuriya 18

Kushagra Dubey 37

M

Mohammed A Alshawsh 9

N Niveena Varghese 22

Nagashree K S 38

P

Parvathy B Nair 42

R

Ramanamoorthy Kandula 33

S Sreelakshmi Sreekumar 12

Sivaram Hariharan 13 & 28

Savitha R S 16

Shubham Babu Gupta 17

S D Muralidass 21

Sadia Sultan 25

Sabiha Imran 05

S Elavarasi 30

Shefin Siby 43

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Pharma-2021

2nd International

Pharma Conference February 2021

Reignite Innovative Conference

Allwyn, Hyderabad, India

Pin:500042

Ph.No: 9951631020

Email: [email protected]

Website: www.thereignite.com

mailto:[email protected]

http://www.thereignite.com/

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