8/14/2019 perhitungan stabilitas obat

1/20

V. HASIL PERCOBAAN

V.1 Data Hasil Percobaan

T ( C0) t ( menit ) Absorbansi ( mg/100ml )

40

10

20

30

40

0.063

0,083

0,808

0,116

55

10

2030

40

0,058

0,1460,218

0,238

70

10

20

30

40

0,368

0,524

0,604

0,719

V.II Perhitungan

i!eta"#i $ %& Asam 'alisilat $ 138,08

%& Asirin $ 180,164

& asirin $ 0,1004

ersamaan !#r*a ba!# $ + 0,128- 0,04

1. Co( !onsentrasi asetosal m#lam#la )

Co31011,1

l0,5-g/ml180,164

1004,0

== x

2. taa s#"# 40oC

t 40 + 0,128- 0,04

0,063 0,128- 0,04

mlmg 100/1797,0128,0

0,040,063==

0,1797 - 10

3

g/l

8/14/2019 perhitungan stabilitas obat

2/20

lgxlgx

Xt /10301,108,138

/10797,1 53

==

20

+ 0,128-0,04

0,083 0,128-0,04

mlmgX 100/336,0128,0

04,0083,0=

=

3,36 - 10

3

g//l

lgxlgx

Xt /1043,208,138

/1036,3 53

==

30

+ 0,128-0,04

0,108 0,128-0,04

mlmgX 100/531,0128,0

04,0108,0=

=

5,31 - 10

3

g/l

lgxlgx

Xt /10845,308,138

/1031,5 53

==

30

+ 0,128-0,04

0,116 0,128-0,04

mlmgX 100/594,0128,0

04,0116,0=

=

5,94 - 10

3

g/l

8/14/2019 perhitungan stabilitas obat

3/20

8/14/2019 perhitungan stabilitas obat

4/20

1,39 - 10

2

g/l

lgxlgx

Xt

/10007,108,138

/1039,1 42

==

40

+ 0,128-0,04

0,238 0,128-0,04

mlmgX 100/547,1128,0

04,0238,0=

=

1,547 - 10

2

g/l

lgxlgx

Xt /1012,108,138

/10547,1 42

==

aa '#"# 70

o

C

10

+ 0,128-0,04

0,368 0,128-0,04

mlmgX 100/5625,2128,0

04,0368,0=

=

2,5625 - 10

2

g/l

lgxlgx

Xt /10856,108,138

/105625,2 42

==

20

+ 0,128-0,04

0,524 0,128-0,04

mlmgX 100/781,3128,0

04,0524,0=

=

8/14/2019 perhitungan stabilitas obat

5/20

3,781 - 10

2

g/l

lgxlgx

Xt

/10738,208,138

/10781,3 42

==

30

+ 0,128-0,04

0,604 0,128-0,04

mlmgX 100/406,4128,0

04,0604,0=

=

4,406 - 10

2

g/l

lgxlgx

Xt /10191,308,138

/10406,4 42

==

40

+ 0,128-0,04

0,719 0,128-0,04

mlmgX 100/395,5128,0

04,0719,0=

=

5,395 - 10

2

g/l

lgxlgx

Xt /10842,308,138

/10305,5 42

==

3. onsentrasi Asirin aa t tertent#

aa s#"# 40

o

C

8/14/2019 perhitungan stabilitas obat

6/20

Ct Co

t

C

10

1,11 - 10

3

1,301 - 10

5

1,0969 - 10

3

g/l

C20

1,11 - 10

3

2,43 - 10

5

1,0857 - 10

3

g/l

C30

1,11 - 10

3

3,845 - 10

5

1,0715 - 10

3

g/l

C40

1,11 - 10

3

4,3 - 10

5

1,067 - 10

3

g/l

aa s#"# 50

o

C

Ct Co

t

C10

1,11 - 10

3

1,018 - 10

5

1,0998 - 10

3

g/l

C20

1,11 - 10

3

5,996 - 10

5

1,0501 - 10

3

g/l

C30

1,11 - 10

3

1,007 - 10

4

1,0093 - 10

3

g/l

C40

1,11 - 10

3

1,12 - 10

4

0,998 - 10

3

g/l

aa s#"# 40

o

C

Ct Co

t

C10

1,11 - 10

3

1,856 - 10

4

0,9244 - 10

3

g/l

C20

1,11 - 10

3

2,738 - 10

4

0,8362 - 10

3

g/l

C30

1,11 - 10

3

3,191 - 10

4

0,7909 - 10

3

g/l

8/14/2019 perhitungan stabilitas obat

7/20

C40

1,11 - 10

3

3,842 - 10

4

0,7258 - 10

3

g/l

T (

o

C) t

(menit)

(g/l) t (g/l) Ct (g/l) og Ct 1/Ct

40 10

20

30

40

0,1797

0,336

5,31-10

3

5,94 -10

3

1,301 -10

5

2,43 -10

5

3,845 -10

5

4,3 -10

5

1,0969 -10

3

1,0857 -10

3

1,0715 -10

3

1,067 -10

3

2,959

2,964

2,969

2,971

911,66

921,064

933,22

937,21

55 10

20

30

40

1,406 -10

3

8,28 -10

3

1,39 -10

2

1,547 -10

2

1,018 -10

5

5,996 -10

5

1,007 -10

4

1,12 -10

4

1,0998 -10

3

1,0501 -10

3

1,0093 -10

3

0,998 -10

3

2,958

2,978

2,995

3,0008

909,256

952,29

990,785

1002,004

70 10

20

30

40

2,5625 -10

2

3,781 -10

2

4,406 -10

2

5,305 -102

1,856 -10

4

2,738 -10

4

3,191 -10

4

3,842 -104

0,9244 -10

3

0,8362 -10

3

0,7909 -10

3

0,7258 -103

3,034

3,077

3,102

3,139

1081,782

1195,886

1264,382

1377,79

8/14/2019 perhitungan stabilitas obat

8/20

8/14/2019 perhitungan stabilitas obat

9/20

2,572

3010.0093,110.11,1

10.007,1

33

5

30 xxK

=

2,996

4010.998,010.11,1

10.12,133

5

40xx

K

=

2,5275

aa '#"# 70oC

1010.9244,010.11,1

10.856,133

4

10xx

K

=

18,088

2010.8362,010.11,1

10.738,233

4

20xxK

=

14,927

3010.7909,010.11,1

10.191,333

4

30xx

K

=

12,116

4010.7258,010.11,1

10.842,333

4

40xx

K

=

11,922

7. ratarata

8/14/2019 perhitungan stabilitas obat

10/20

'#"# 40

o

C

4

9076,0775,10082,10085,1 +++=

ratarataK

1, 01545

'#"# 55

o

C

4

5225,2996,2572,28352,0 +++=ratarataK

2,233

'#"# 70

o

C

4

922,11116,12927,14088,18 +++=

ratarataK

14,263

8. a!t# ar#"

'#"# 40

o

C

01545,110.11,1

1

2

1

3xT

=

887,194 menit 14,79 am

'#"# 55

o

C

233,210.11,1

1

2

13x

T

=

8/14/2019 perhitungan stabilitas obat

11/20

403,448 menit 6,72 am

'#"# 70

o

C

263,1410.11,1

1

2

13x

T

=

63,163 menit 1,052 am

9. Tabel

T(

o

C) T() 1/T (el*in) ratarata og

40 313 1/313 1,01545 6,658.10

3

55 328 1/328 2,233 0,348

70 343 1/343 14,263 1,154

#r*a ersamaan %a!#

+ b- a

+ 4078,2002- 12,95

aa s#"# 27

o

C 300

o

300

11==

TK

+ 4078,2002- 12,95

95,12300

1../4078,2002log 27 +

=K

8/14/2019 perhitungan stabilitas obat

12/20

log27

0,644

27

0,227

90

10 . C

10 . (1,11 - 10

3

)

1,11 - 10

4

2790).(

90.90t

KXtCoCo

Xt

=

227,0).10.11,110.11,1.(10.11,1

10.11,1433

4

=

7

4

10.5171,2

10.11,1

=

440,9836 menit

8/14/2019 perhitungan stabilitas obat

13/20

:::. AAT A; %A

8/14/2019 perhitungan stabilitas obat

14/20

:. CABA @BA

itimbang

ilar#t!an

iener!an samai 1 liter

iambil

imas#!!an !e alam 5

tab#ng rea!si, masing

masing 10,0 ml.

ianas!an aa s#"#

40

o

C.

iambil 1 tab#ng stela"

s#"# +ang iingin!an.

iingin!an alam es

iambil lagi 1 botol tia

10 menit "ingga tab#ng

!e lima.

Asetosal 0,1 g

Asetosal 0,1 g

A?#aes

ar#tan am#ran asetosal,

alo"ol an a?#aes i atas

8/14/2019 perhitungan stabilitas obat

15/20

masingmasing tab#ng

iingin!an setela"

iambil.

iambil 2 ml lal#

itamba"!an aa

masingmasing tab#ng.

igoo! "ingga "omogen.

ibaa seraann+a aa D

525 nm

i#langi erobaan

engan s#"# 55

o

C an

70

o

C

Ee;F31 alam asam nitrat

8/14/2019 perhitungan stabilitas obat

16/20

V.III ra!i"

a. =ra>i! "#b#ngan antara t an Ct ore nol aa s#"# 40oC

0,001065

0,00107

0,001075

0,00108

0,001085

0,00109

0,001095

0,0011

0 10 20 30 40 50

Series1

=ra>i! "#b#ngan antara t an Ct ore nol aa 55oC

0,00098

0,001

0,00102

0,00104

0,00106

0,00108

0,0011

0,00112

0 10 20 30 40 50

Series1

=ra>i! "#b#ngan antara t an Ct ore nol aa 70oC

8/14/2019 perhitungan stabilitas obat

17/20

0

0,0002

0,0004

0,0006

0,0008

0,001

0 10 20 30 40 50

Series1

b. =ra>i! "#b#ngan antara t an log Ct s#"# 40oC

-2,972

-2,97

-2,968

-2,966

-2,964

-2,962

-2,96

-2,958

0 10 20 30 40 50

Series1

=ra>i! "#b#ngan antara t an log Ct aa s#"# 55oC

8/14/2019 perhitungan stabilitas obat

18/20

-3,005

-3

-2,995

-2,99

-2,985

-2,98

-2,975

-2,97

-2,965

-2,96

-2,955

0 10 20 30 40 50

Series1

=ra>i! "#b#ngan antara t an log Ct aa s#"# 70oC

-3,16

-3,14

-3,12

-3,1

-3,08

-3,06

-3,04

-3,02

0 10 20 30 40 50

Series1

C. =ra>i! "#b#ngan antara t an log 1/Ct aa ore :: aa s#"#

40oC

8/14/2019 perhitungan stabilitas obat

19/20

910

915

920

925

930

935

940

0 10 20 30 40 50

Series1

=ra>i! "#b#ngan antara t an log 1/Ct aa ore :: aa s#"# 55oC

900

920

940

960

980

1000

1020

0 10 20 30 40 50

Series1

=ra>i! "#b#ngan antara t an log 1/Ct aa ore :: aa s#"# 70oC

8/14/2019 perhitungan stabilitas obat

20/20

0

200

400

600

800

1000

1200

1400

1600

0 10 20 30 40 50

Series1

=ra>i! "#b#ngan 1/T an log ratarata

0

0,2

0,4

0,6

0,8

1

1,2

1,4

0,0029 0,003 0,0031 0,0032 0,0033

Series1