Penentuan Profil Laju Disolusi Tablet Lepas Lambat Asetosal
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Penentuan Profil Laju Disolusi Tablet Lepas Lambat Asetosal Tablet I 5’ 0,0286 A 0,0286 = 0,005x – 0,036 x = 0,0 286 + 0,036 0,005 = 12,92 g/mL Dalam 1000 mL larutan = 12,92 g/mL x 900 mL = 11628 g = 11,628 mg % disolusi = 11,628 x 100% 250 = 4,65 % 10’ 0,0415 A 0,0415 = 0,005x – 0,036 x = 0,0 415 + 0,036 0,005 = 15,5 g/mL Dalam 1000 mL larutan = 15,5 g/mL x 900 mL = 13950 g = 13,95 mg
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Transcript of Penentuan Profil Laju Disolusi Tablet Lepas Lambat Asetosal
Penentuan Profil Laju Disolusi Tablet Lepas Lambat Asetosal
Tablet I
5’ 0,0286 A
0,0286 = 0,005x – 0,036
x = 0,0 286 + 0,036
0,005
= 12,92 g/mL
Dalam 1000 mL larutan
= 12,92 g/mL x 900 mL
= 11628 g
= 11,628 mg
% disolusi = 11,628 x 100%
250
= 4,65 %
10’ 0,0415 A
0,0415 = 0,005x – 0,036
x = 0,0 415 + 0,036
0,005
= 15,5 g/mL
Dalam 1000 mL larutan
= 15,5 g/mL x 900 mL
= 13950 g
= 13,95 mg
Faktor koreksi
= 13,95 + 10 x 11,628
900
= 13,95 + 0,1292
= 14,0792 mg
% disolusi = 14,0792 x 100%
250
= 5,63 %
15’ 0,0531 A
0,0531 = 0,005x – 0,036
x = 0,0 531 + 0,036
0,0005
= 17,82 g/mL
Dalam 1000 mL larutan
= 17,82 g/mL x 900 mL
= 16038 g
= 16,038 mg
Faktor koreksi
= 16,038 + 10 x 14,0792
900
= 16,038 + 0,1564
= 16,1944 mg
% disolusi = 16,1944 x 100%
250
= 6,48 %
30’ 0,0596 A
0,0596 = 0,005x – 0,036
x = 0,2030 + 0,036
0,005
= 19,12 g/mL
Dalam 1000 mL larutan
= 19,12 g/mL x 900 mL
= 17208 g
= 17,208 mg
Faktor koreksi
= 17,208 + 10 x 16,1944
900
= 17,208 + 0,1799
= 17,3789 mg
% disolusi = 17,3789 x 100%
250
= 6,88 %
45’ 0,0684 A
0,0684 = 0,005x – 0,036
x = 0, 0684 + 0,036
0,005
= 20,88 g/mL
Dalam 1000 mL larutan
= 20,88 g/mL x 900 mL
= 18792 g
= 18,792 mg
Faktor koreksi
= 18,792 + 10 x 17,3879
900
= 18,792 + 0,1931
= 18,9851 mg
% disolusi = 18,9851 x 100%
250
= 7,59 %
60’ 0,0723 A
0,0723 = 0,005x – 0,036
x = 0, 0723 + 0,0367
0,005
= 21,66 g/mL
Dalam 1000 mL larutan
= 21,66 g/mL x 900 mL
= 19494 g
= 19,494 mg
Faktor koreksi
= 19,494 + 10 x 18,9851
900
= 19,494 + 0,21
= 19,704 mg
% disolusi = 19,704 x 100%
250
= 7,88 %
75’ 0,0798 A
0,0798 = 0,005x – 0,036
x = 0, 0798 + 0,036
0,005
= 23,16 g/mL
Dalam 900 mL larutan
= 23,16 g/mL x 900 mL
= 20844 g
= 20,844 mg
Faktor koreksi
= 20,844 + 10 x 19,704
900
= 20,844 + 0,2189
= 21,0629 mg
% disolusi = 21,0629 x 100%
250
= 8,43 %
90’ 0,0825 A
0,0825 = 0,005x – 0,036
x = 0, 0825 + 0,036
0,005
= 23,7 g/mL
Dalam 900 mL larutan
= 23,7 g/mL x 900 mL
= 21330 g
= 21,33 mg
Faktor koreksi
= 21,33 + 10 x 21,0629
900
= 21,33 + 0,234
= 21,564 mg
% disolusi = 21,564 x 100%
250
= 8,63 %
105’ 0,0938 A
0,0938 = 0, 0,005x – 0,036
x = 0, 0938 + 0,036
0,005
= 25,96 g/mL
Dalam 900 mL larutan
= 25,96 g/mL x 900 mL
= 23364 g
= 23,364 mg
Faktor koreksi
= 23,364 + 10 x 21,564
900
= 23,364 + 0,2396
= 23,6036 mg
% disolusi = 23,6036 x 100%
250
= 9,44 %
120’ 0,1035 A
0,1035 = 0,005x – 0,036
x = 0, 1035 + 0,036
0,005
= 27,9 g/mL
Dalam 900 mL larutan
= 27,9 g/mL x 900 mL
= 25110 g
= 25,11 mg
Faktor koreksi
= 25,11 + 10 x 23,6036
900
= 25,11 + 0,2623
= 25,2723 mg
% disolusi = 25,3723 x 100%
250
= 10,15 %
150’ 0,1216 A
0,1216 = 0,005x – 0,036
x = 0, 1216 + 0,036
0,005
= 31,52 g/mL
Dalam 900 mL larutan
= 31,52 g/mL x 900 mL
= 28328 g
= 28,368 mg
Faktor koreksi
= 28,368 + 10 x 25,3723
900
= 28,368 + 0,2819
= 28,6499 mg
% disolusi = 28,6499 x 100%
250
= 11,46 %
180’ 0,1249 A
0,1249 = 0,005x – 0,036
x = 0, 1249 + 0,036
0,005
= 32,18 g/mL
Dalam 900 mL larutan
= 32,18 g/mL x 900 mL
= 28962 g
= 28,693 mg
Faktor koreksi
= 28,693 + 10 x 28,6499
900
= 28,693 + 0,3183
= 29,2803 mg
% disolusi = 29,2803 x 100%
250
= 11,71 %
210’ 0,1372 A
0,1372 = 0,005x – 0,036
x = 0, 1372 + 0,036
0,005
= 34,64 g/mL
Dalam 900 mL larutan
= 34,64 g/mL x 900 mL
= 31176 g
= 31,176 mg
Faktor koreksi
= 31,176 + 10 x 29,2803
900
= 31,176 + 0,3253
= 31,5013 mg
% disolusi = 31,5013 x 100%
250
= 12,6 %
240’ 0,1511 A
0,1511 = 0,005x – 0,036
x = 0, 1511 + 0,036
0,005
= 37,42 g/mL
Dalam 900 mL larutan
= 37,42 g/mL x 900 mL
= 33678 g
= 33,678 mg
Faktor koreksi
= 33,678 + 10 x 31,5013
900
= 33,678 + 0,35
= 34,028 mg
% disolusi = 34,028 x 100%
250
= 13,61 %
270’ 0,1537 A
0,1537 = 0,005x – 0,036
x = 0, 1537 + 0,036
0,005
= 38,66 g/mL
Dalam 900 mL larutan
= 38,66 g/mL x 900 mL
= 34794 g
= 34,794 mg
Faktor koreksi
= 34,794 + 10 x 34,028
900
= 34,794 + 0,378
= 35,172 mg
% disolusi = 35,712 x 100%
250
= 14,07 %
300’ 0,165 A
0,165 = 0,005x – 0,036
x = 0, 165 + 0,036
0,005
= 40,2 g/mL
Dalam 900 mL larutan
= 40,2 g/mL x 900 mL
= 36180 g
= 36,18 mg
Faktor koreksi
= 36,18 + 10 x 35,172
900
= 36,18 + 0,3908
= 36,5708 mg
% disolusi = 36,5708 x 100%
250
= 14,63 %
330’ 0,1719 A
0,1719 = 0,005x – 0,036
x = 0, 1719 + 0,036
0,005
= 41,58 g/mL
Dalam 900 mL larutan
= 41,58 g/mL x 900 mL
= 37422 g
= 37,422 mg
Faktor koreksi
= 37,422 + 10 x 36,5708
900
= 37,422 + 0,3908
= 37,8283 mg
% disolusi = 37,8283 x 100%
250
= 15,13 %
360’ 0,1932 A
0,1932 = 0,005x – 0,036
x = 0, 1932 + 0,03 6
0,005
= 45,84 g/mL
Dalam 900 mL larutan
= 45,84 g/mL x 900 mL
= 41256 g
= 41,256 mg
Faktor koreksi
= 41,256 + 10 x 37,8283
900
= 41,256 + 0,4203
= 41,6763 mg
% disolusi = 41,6763 x 100%
250
= 16,67 %
Q1 = 10,308
