RETINOBLASTOMA

EPIDEMIOLOGITumor primer, maligna, intraokular paling banyak pada (1:20,000) 2. Muncul sebelum usia 3 tahun3. Diturunakn (40%) or tidak diturunkan (60%)

4. Gen yang berperan(RPE 1) on 13q14

Leukocoria - 60% Strabismus - 20% Secondary glaucoma Anterior segment invasion Orbital inflammation Orbital invasionPresentasi Klinis dari retinoblastoma

Retinoblastoma Endofitik (awal)White flat lesionPlacoid lesion

Retinoblastoma Endofitik (Lanjut)Friable white massCottage cheese appearanceFine surface blood vesselsVitreous seedings

Retinoblastoma EksofitikMultiglobulated white mass withoverlying retinal detachmentMay be difficult to visualize through deep detachment

CT SCANCalcification Optic nerve involvement Orbital and CNS extension Pinealoblastoma

Terapi Retinoblastoma1. Small tumours Laser photocoagulation Transpupillary thermotherapy Cryotherapy2. Medium tumours Brachytherapy Chemotherapy External beam radiotherapy3. Large tumours Chemotherapy followed by local treatment Enucleation4. Extraocular extension External beam radiotherapy5. Metastatic disease Chemotherapy

HISTOPATOLOGIWell-differentiated with many Flexner-Wintersteiner rosettesPoorly differentiated

DIAGNOSIS BANDING LEUKORIACongenital cataract Unilateral or bilateral UnilateralInflammatory cycliticmembrane Persistent hyperplasticprimary vitreous Unilateral or bilateralCoats disease Unilateral UnilateralAdvanced retinopathy of prematurityPosterior pole toxocaragranuloma Always bilateral but may be asymmetrical