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HIV

T Lymphocyte

B Lymphocyte

Increasing Number 

of C D8+ Cells

Cellular Immune System

Damaged

Lymphocyte Infiltration

in Salivary Gland

Cytokyne Unable

to Activate

CTLs2 and Macrophage

IncreasingSecretion of IgM

Hipergammaglobulinaemia(IgA and IgG)

Lymphocyte

Disruption

 Antibody FormationDeranged

Candida Albicans

Inflammatory

Decreasing Number 

of CD4+ Cells

XerostomiaSaliva Has Loss Function

to Oral Self-Cleansing

S. Mutans Bacteria

Colonized

Decreasing

Oral pHDemineralization

Increasing Opportunistic

Infection

Bacterial

Infection

Fungal

Infection

DiarrheaCaries

 Acute

Pseudomem-

branous

Candidiasis

Decreasing BodyWeight

Decreasing

Saliva pH

Replication in LocalLymph Gland

Virus Infects Host

Occurs on CD4+ Cell,

Macrophage, and Dendritic Cells

in Blood and Lymphoid Organ

Viremia