Post on 09-Jan-2016
description
CYTOKINE PADA HEMOPOETIK SEL
Muh. Ilyas Yusuf, Apt
PERAN SITOKIN DALAM PEMBENTUKAN SEL IMUN
FUNGSI CYTOKINE :
- MENGATUR (REGULATE) PERTUMBUHAN SEL MEMACU AKTIFITAS SEL PROSES INFLAMASI PROSES IMUNITAS TISSUE REPAIR PROSES FIBROSIS MORFOGENESIS
Stem cells in the bone marrow
M2M1BTH2NKNKTMDCDCBCDTL8 CGR1 CD 11bmabaeoTH1CD4,28,FOXP3CD8,28CD4,28CD4,28Reactive oxygen, NO, IL-1b, TNF alfa,, IL-6, 12,23, tissue destruction, killing of parasit, tumors resistenIL-2, TNF- IFN-MIG, IP 10Tipe II inflamation, tissue remodelling, angeogenesis, parasit encapsulation, tumor promotion, IL 10 TGF beta, arginaseMucuc producing cellsIL-15, 18Differentiation Ig subtype switchingT regulatory cellsIFN-IFN-, GM-CSF, TNF-IL-4, 13IL-4, 13IL-4, 13IL-2IFN-IL-10, TGF-IFN-, GM-CSF, TNF-IL-10, TGF-Endothelial cellsIL-10,TGF-IL-10IL-10, TGF-Endothelial cellsIL-2, 23IMMUNE REGULATIONIL-4,10,13IFN-IL-10, TGF-IL-10, TGF-IL-4,10,13,IFN-IFN-IFN-IFN-IFN-IL-10,TGF-IL-10, TGF-IL-10, TGF-IL-10, TGF-B; B cell, ba:basophil, CTL;cytotoxic cell T, DC: dendrit cell, Eo:eosinophile, M; monocyte, Ma; mastcells, M1; macrophage, M2: macrophage, NK:natural killer cell, NKT;natural killer T cell, Th; T helper cell.
Cell sources and target cell effects of TGFTransfor-ming growth factor (T.G.F.B)target cell effectscell sourcesT cellB cellinhibits T cell proliferation and lymphokine productioninhibits B cell proliferation and antibody productioninhibits early hematopoietic stem cell replicationattracts macrophagesinhibits natural killer activityosteoclast activation in bonestimulates and mobilizes fibroblasts wound healing collagen, fibronectin and collagenasemacrophagesplateletsplacenta, bone and kidneysuppresses proliferation of epithelial cells, fetal hepatocytes, and endothelial cells
TTNF and TNF (LT)T lymphocytesB lymphocytesIL-2, IL-4IFN-IFNCSFIL-4LDCFIL-2 lymphokine production IL-2 receptorsproliferate antibody productionbone marrow inhibits in vitro hematopoiesis but stimulates CSF in vivoPMNsneutrophilia metabolic activation chemoattractsmacrophages prostaglandinsand mediatescytocidal activation IL-1, IL-6, IL-8, GMCSF
EFEK SITOKIN PD IMUNO DEFISIENSIIMUNO DEFISIENSI TERJADI KARENA ADANYA KECACATAN GENETIK DARI SEL IMUNOKOMPETEN. KECACATAN INI DAPAT TERJADI KARENA ADANYA FAKTOR TERTENTU SEPERTI RADIASI, INFEKSI VIRUS ATAU SUATU RADIKAL BEBAS.Efek biologis dr sitokin sangat menentukan respon imun seseorangAPCIL-12TH-2TH-1TH-0CTLLIMF-BSEL PLASMASEL MEMORISEL-NKIL-2 IFN-IL-2 IFN-IL-1TNF- IFN-IFN-IL-5IL-4IL-6ANTIBODIIL-10
SELESAI