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EFFECTS OF A COMBINED MICRONUTRIENT
SUPPLEMENTATION ON MATERNAL
BIOLOGICAL STATUS AND NEWBORN ANTHROPOMETRICS MEASUREMENTS: A
RANDOMIZED DOUBLE-BLIND, PLACEBO-
CONTROLLED TRIAL IN APPARENTLY
HEALTHY PREGNANT WOMEN
Pembimbing : dr. Min Kyaw Htet, MBBBS, M.Med.Sc, PhD
dr. Rina K.Kusumaratna, M.Kes
Journal Reading Jakarta, May 2016
I Hininger, M Favier, J Arnaud, H Faure, JM Thoulon, E Hariveau, A Favier, AM
Roussel.
Departement of Public Health
Faculty of Medicine – Trisakti University
GROUP VII
JUSTHESYA FITRIANI F.P (030.07.128)
YUTI PURNAMASARI (030.09.282)
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JOURNAL IDENTITY
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IDENTITY
• Effects of a combined micronutrient supplementation on maternalbiological status and newborn anthropometrics measurements: arandomized double-blind, placebo-controlled trial in apparentlyhealthy pregnant women
Title :
• Prospective study
Type :
• I Hininger, M Favier , et.al.
Researcher :
• European Journal of Clinical Nutrition p.52-59•
Department of obstetrics and gynecology, France
Publicated on:
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INTRODUCTION
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ON
• Micronutrient deficiencies contribute to impaired growth,health, and development (Ladipo, 2000) and the relation betweenmaternal diet and the physical measurements of the new bornhas been described
• Pregnant woman• New born
Associated with:
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NT
Deficiencypercentage ofnutrient inpregnant
Effect toanthropometrynew born baby
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GOAL
Effects of
multivitamin danmultimineral
supplement
Healthy
pregnant
woman
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SUBJECTS AND METHODS
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METHOD
• A total of 100 apparently healthy women receiving prenatalcare between 12 and 16 weeks of gestation in the ObstetricDepartments of Grenoble and Lyon Hospitals in France
Subject
• the supplement or the placebo from 1472 weeks of gestationto delivery. The tablets were given out for 2 months, but withthe recommendation to return the residual blisters everymont
Treatmet
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METHOD
• The subjects received a daily supplement containing vitaminC (60 mg), b-carotene (4.8 mg), vitamin E (10 mg), thiamin(1.4 mg), riboflavin (1.6 mg), niacin (15 mg), pantothenic acid(6 mg), folic acid (200 mg), cobalamin (1 mg), Zn (15 mg ascitrate), Mg (87.5 mg as glycerophosphate), Ca (100 mg as
carbonate) or a placebo.
Supplementation
• At birth, weight, height and clinical parameters weremeasured in newborns. Maternal blood samples were
collected after overnight fasting, at the enrolment (1472weeks) and at the last prenatal visit
Clinical follow-up and sampling
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MICRONUTRIENT DETERMINATIONS
Plasma zinc and copper, and red blood cell copper
concen-trations were determined by flame atomicabsorption spectrometry
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RESULTS
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S
Table 1. baseline characteristic of participating woman at enrolmant
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DISCUSSION
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ON
• As expected, the supplemental intake of vitamins wasefficient to improve significantly the blood levels of vitaminE, C, b-carotenes, folic acid, B2 and B6
• The study did not find statistical differences Effects ofmicronutrients on pregnant women and newborn
In this study:
• maternal supplementation resulted in a positive
effect on infant birth weights, and significantlyreduced the number of infants with birthweights below 2700 g which is associated withan increased risk of morbidity
In this study showed that:
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DISCUSSION (2)
a positive effect of supplementa-tion using single
micronutrient such as Zn Mg (Makrides &
Crowther, 2000) or folate (Iyengar & Rajalaksh-
mi, 1975; Rolschau et al, 1981). Recently, the role
of vitamins E and C in preventing prematurerupture of membrane, which could lead to an
increased birth weight, was also hypothesized
(Woods et al, 2001). Since the gestational age was
not different between the two groups, a possibleinfluence of the maternal nutrient cannot be
excluded.
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CONCLUSION
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CONCLUSION
• This randomized double-blind study suggeststhat the use of combined micronutrimentsupplements, at nutritional doses, improved
babies birth weight and maternal biologicalstatus. These preliminary results need to beconfirmed in larger further studies, but suggestthat optimal micronutrient nutrition should beencouraged, not only in women with poor
nutritional status or in complicatedpregnancies, but also in apparently healthypregnant women, without any particular lifestyle risk
Concluded that:
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QUESTIONS & ANSWERS
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1. Based on the journal that we read, we got new information that the
use of combined micronutriment supplements at nutritional doses
improved babies birth weight and maternal biological status, while
the number of infants with birth weights below 2!!g was
significantl" higher in placebo.
2. #o one information which is not in line with us
$. %he paper ver" helpful as a source of &nowledge to improve
nutritional status of indonesian children or people.
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REFERENCES
REFERENCES
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REFERENCES
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2.Arnaud J, Bellanger J, Chappuis P, Favier A & Galliot M (1985):
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absorption spectrometry. Ann. biol. Clin. 43, 297–318.
3.Arnaud J, Fortis I, Blachier S, Kia D & Favier A (1991): Simultaneous
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B1, B2 and B6. Clin Chem 22, 327–335.
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REFERENCES(2)
7.Briefel RR, Bialostosky K, Kennedy-Stephenson J, McDowell MA,
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8.Brown KH, Peerson JM & Allen LH (1998): Effect of zinc supple-
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9.Cargnoni AA, Gregorini G, Ceconi C, Maiorca R & Ferrari R
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THANK YOU