WO 2009/143603 Al

(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT)

(19) World Intellectual Property OrganizationInternational Bureau

(10) International Publication Number(43) International Publication Date3 December 2009 (03.12.2009) WO 2009/143603 Al

(51) International Patent Classification: (74) Agent: MBM INTELLECTUAL PROPERTY LAWC40B 40/06 (2006.01) C40B 30/04 (2006.01) LLP; P . O . Box 809 Stn. B, Ottawa, Ontario KlP 5P9C12Q 1/68 (2006.01) C07H 21/00 (2006.01) (CA).

(21) International Application Number: (81) Designated States (unless otherwise indicated, for everyPCT/CA2009/000694 kind of national protection available): AE, AG, AL, AM,

AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ,(22) International Filing Date: CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ,

28 May 2009 (28.05.2009) EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN,(25) Filing Language: English HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR,

KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME,(26) Publication Language: English MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO,

(30) Priority Data: NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG,

61/056,827 28 May 2008 (28.05.2008) US SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA,UG, US, UZ, VC, VN, ZA, ZM, ZW.

(71) Applicant (for all designated States except US):GENOMEDX BIOSCIENCES, INC. [CA/CA]; (84) Designated States (unless otherwise indicated, for every

460-2609 Granville Street, Vancouver, British Columbia kind of regional protection available): ARIPO (BW, GH,

V6H 3H3 (CA). GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM,ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ,

(72) Inventor; and TM), European (AT, BE, BG, CH, CY, CZ, DE, DK, EE,(75) Inventor/Applicant (for US only): DAVICIONI, Elai ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV,

[CA/CA]; Vancouver, British Columbia (CA). MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR),

[Continued on next page]

(54) Title: SYSTEMS AND METHODS FOR EXPRESSION-BASED DISCRIMINATION OF DISTINCT CLINICAL DISEASE STATES IN PROSTATE CANCER

(57) Abstract: A system for expression-based discrimination of distinct clinical disease states in prostate cancer is provided that isbased on the identification of sets of gene transcripts, which arecharacterized in that changes in expression of each gene transcriptwithin a set of gene transcripts can be correlated with recurrent ornon-recurrent prostate cancer. The Prostate Cancer Prognostic sy stem provides for sets of "prostate cancer prognostic" target se

quences and further provides for combinations of polynucleotideprobes and primers derived there from. These combinations ofpolynucleotide probes can be provided in solution or as an array.The combination of probes and the arrays can be used for diagnosis.The invention further provides further methods of classifyingprostate cancer tissue.

Figure 1Λ

OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, before the expiration of the time limit for amending theMR, NE, SN, TD, TG). claims and to be republished in the event of receipt of

Published: amendments (Rule 48.2(h))

SYSTEMS AND METHODS FOR EXPRESSION-BASED DISCRIMINATION

OF DISTINCT CLINICAL DISEASE STATESIN PROSTATE CANCER

FIELD OF THE INVENTION

This invention relates to the field of diagnostics and in particular to systems and methods for

classifying prostate cancer into distinct clinical disease states.

BACKGROUND

Prostate cancer is the most common malignancy affecting U.S. men, with approximately 240,

000 new cases diagnosed each year. The incidence of prostate cancer is increasing, in part due to

increased surveillance efforts from the application of routine molecular testing such as prostate-

specific antigen (PSA). For most men, prostate cancer is a slow-growing, organ-confined or

localized malignancy that poses little risk of death. The most common treatments for prostate

cancer in the U.S. are surgical procedures such as radical prostatectomy, where the entire

prostate is removed from the patient. This procedure on its own is highly curative for most but

not all men.

The vast majority of deaths from prostate cancer occur in patients with metastasis, believed to be

present already at the time of diagnosis in the form of clinically undetectable micro-metastases.

In these patients, it is clear that prostatectomy alone is not curative and additional therapies such

as anti-androgen or radiation therapy are required to control the spread of disease and extend the

life of the patient.

Most prostatectomy patients however face uncertainty with respect to their prognosis after

surgery: whether or not the initial surgery will be curative several years from the initial

treatment because the current methods for assessment of the clinical risk such as the various

pathological (e.g., tumor stage), histological (e.g., Gleason's), clinical (e.g., Kattan nomogram)

and molecular biomarkers (e.g., PSA) are not reliable predictors of prognosis, specifically

disease progression. Routine PSA testing has certainly increased surveillance and early-detection

rates of prostate cancer and this has resulted in an increased number of patients being treated but

not significantly decreased the mortality rate.

Despite the controversies surrounding PSA testing as a screening tool, most physicians

confidently rely on PSA testing to assess pre-treatment prognosis and to monitor disease

progression after initial therapy.Successive increases in PSA levels above a defined threshold

value or variations thereof (i.e. 'Rising-PSA'), also known as biochemical recurrence has been

shown to be correlated to disease progression after first-line therapy (e.g., prostatectomy,

radiation and brachytherapy). However, less than a 1/3 of patients with 'rising-PSA' will

eventually be diagnosed with systemic or metastatic disease and several studies have shown that

after long-term follow up, the majority will never show any symptoms of disease progression

aside from increases in PSA measurement. The limitations of using the PSA biomarker and the

absence of additional biomarkers for predicting disease recurrence have led to the development

of statistical models combining several clinical and pathological features including PSA results.

Several of these 'nomograms' have been shown to improve the predictive power for disease

recurrence in individual patients over any single independent variable. These models (see

Citation #14) are used routinely in the clinic and are currently the best available tools for

prediction of outcomes, although they do not provide high levels of accuracy for groups of

patients with highly similar histological/pathological features or those at 'intermediate' risk of

disease recurrence after prostatectomy.

The use of quantitative molecular analyses has the potential to increase the sensitivity, specificity

and/or overall accuracy of disease prognosis and provide a more objective basis for

determination of risk stratification as compared to conventional clinical-pathological risk models

(see Citation #13). The PSA test demonstrates the deficiencies of relying on the measurement of

any single biomarker in clinically heterogeneous and complex prostate cancer genomes.

Therefore, genomic-based approaches measuring combinations of biomarkers or a signature of

disease recurrence are currently being investigated as better surrogates for predicting disease

outcome (see Citations # 1-13). For prostate cancer patients these efforts are aimed at reducing

the number of unnecessary surgeries for patients without progressive disease and avoid

inadvertent under-treatment for higher risk patients. To date, genomic profiling efforts to

identify DNA-based (e.g., copy-number alterations, methylation changes), RNA-based (e.g.,

gene or non-coding RNA expression) or protein-based (e.g., protein expression or modification)

signatures, useful for disease prognosis have not however resulted in widespread clinical use.

There are several key reasons explaining why prior genomic profiling methods for prostate

cancer have not yet been incorporated in the clinic. These include the small sample sizes typical

of individual studies, coupled with variations due to differences in study protocols, clinical

heterogeneity of patients and lack of external validation data, which combined have made

identifying a robust and reproducible disease signature elusive. Specifically for gene or RNA

expression based prognostic models; the mitigating technological limitations include the quality

and quantity of RNA that can be isolated from routine clinical samples. Routine clinical samples

of prostate cancer include needle-biopsies and surgical resections that have been fixed in

formalin and embedded in paraffin wax (FFPE). FFPE-derived RNA is typically degraded and

fragmented to between 100-300 bp in size and without poly-A tails making it of little use for

traditional 3'-biased gene expression profiling, which requires larger microgram quantities of

RNA with intact poly-A tails to prime cDNA synthesis.

Furthermore, as <2% of the genome encodes for protein, traditional gene expression profiling in

fact captures only a small fraction of the transcriptome and variation in expression as most RNA

molecules that are transcribed are not translated into protein but serve other functional roles and

non-coding RNAs are the most abundant transcript species in the genome.

This background information is provided for the purpose of making known information believed

by the applicant to be of possible relevance to the present invention. No admission is necessarily

intended, nor should be construed, that any of the preceding information constitutes prior art

against the present invention.

SUMMARY OF THE INVENTION

An object of the present invention is to provide systems and methods for expression-based

discrimination of distinct clinical disease states in prostate cancer. In accordance with one aspect

of the present invention, there is provided a system for expression-based assessment of risk of

prostate cancer recurrence after prostatectomy, said system comprising one or more

polynucleotides, each of said polynucleotides capable of specifically hybridizing to a RNA

transcript of a gene selected from the group of genes set forth in Table 3 and/or 6 .

In accordance with another aspect of the present invention, there is provided a nucleic acid array

for expression-based assessment of prostate cancer recurrence risk, said array comprising at least

ten probes immobilized on a solid support, each of said probes being between about 15 and about

500 nucleotides in length, each of said probes being derived from a sequence corresponding to,

or complementary to, a transcript of a gene selected from the group of genes set forth in Table 3

and/or 6, or a portion of said transcript.

In accordance with another aspect of the present invention, there is provided a method for

expression-based assessment of prostate cancer recurrence, said method comprising: (a)

determining the expression level of one or more transcripts of one or more genes in a test sample

obtained from said subject to provide an expression pattern profile, said one or more genes

selected from the group of genes set forth in Table 3 and/or 6, and (c) comparing said expression

pattern profile with a reference expression pattern profile.

In accordance with another aspect of the present invention, there is provided a kit for

characterizing the expression of one or more nucleic acid sequences depicted in SEQ ID NOs: 1-

2 114 comprising one or more nucleic acids selected from (a) a nucleic acid depicted in any of

SEQ ID NOs: 1-21 14; (b) an RNA form of any of the nucleic acids depicted in SEQ ID NOs: 1-

2 114; (c) a peptide nucleic acid form of any of the nucleic acids depicted in SEQ ID NOs: 1-

2 114; (d) a nucleic acid comprising at least 20 consecutive bases of any of (a-c); (e) a nucleic

acid comprising at least 25 consecutive bases having at least 90% sequence identity to any of (a-

c); or (f) a complement to any of (a-e); and optionally instructions for correlating the expression

level of said one or more nucleic acid sequences with the disease state of prostate cancer tissue.

In accordance with another aspect of the present invention, there is provided an array of probe

nucleic acids certified for use in expression-based assessment of prostate cancer recurrence risk,

wherein said array comprises at least two different probe nucleic acids that specifically hybridize

to corresponding different target nucleic acids depicted in one of SEQ ID NOs: 1-21 14, an RNA

form thereof, or a complement to either thereof.

In accordance with another aspect of the present invention, there is provided a device for

classifying a biological sample from a prostate cancer as recurrent or non-recurrent, the device

comprising means for measuring the expression level of one or more transcripts of one or more

genes selected from the group of genes set forth in Table 3 and/or 6; means for correlating the

expression level with a classification of prostate cancer status; and means for outputting the

prostate cancer status.

In accordance with another aspect of the present invention, there is provided a computer-readable

medium comprising one or more digitally-encoded expression pattern profiles representative of

the level of expression of one or more transcripts of one or more genes selected from the group

of genes set forth in Table 3 and/or 6, each of said one or more expression pattern profiles being

associated with a value wherein each of said values is correlated with the presence of recurrent or

non-recurrent prostate cancer.

BRIEF DESCRIPTION OF THE DRAWINGS

These and other features of the invention will become more apparent in the following detailed

description in which reference is made to the appended drawings.

Figure 1. A) Principle components analysis (PCA) of 2,1 14 RNAs identified to be differentially

expressed between tumors from patients with differing clinical outcome (see Table 2 for

comparisons evaluated), PCA plot of 22 prostate cancer tumors shows tight clustering of samples

by clinical outcome of patients (circles, NED; diamonds, PSA; squares, SYS). B) Two-way

hierarchical clustering dendrogram and expression matrix of 526 target sequences (Table 4)

RNAs filtered using linear regression (p<0.01) to identify RNAs that followed either

SYS>PSA>NED or NED>PSA>SYS trend in differential expression. C) Two-way hierarchical

clustering dendrogram and expression matrix of 148 target sequences (Table 5), a subset of the

most differentially expressed transcripts between patients with clinically significant 'recurrent'

(i.e., 'SYS') and 'non-recurrent' (i.e., 'PSA' and 'NED') disease as filtered using a t-test

(p<0.001). For B) and C), sample and RNAs were optimally ordered using Pearson's correlation

distance metric with complete-linkage cluster distances and the expression of each RNA in each

sample was normalized in the heatmap by the number of standard deviations above (blacker) and

below (whiter) the median expression value (grey) across all samples.

Figure 2 . Histograms showing distribution patient's tumor expression levels of a 'metagene'

generated from a linear combination of the 526 RNAs for each clinical group. The histograms

bin samples with similar metagene expression values and significantly separate three modes of

patient metagene scores (ANOVA, p<().()00001) corresponding to the three clinical status groups

evaluated.

Figure 3 . Scatter plots summarizing the mean (± standard deviation) of metagene expression

values for tumor samples from patients in the three clinical status groups (NED; PSA; SYS).

Metagenes were generated from a linear combinations of 6 (A), 18 (♦) or 20 (■) RNAs and

demonstrate highly significant differential expression between clinical groups (ANOVA,

p<().()()0001).

Figure 4 . Box plots showing interquartile range and distribution of 'POP' scores for each

clinical group using an 18-target sequence metagene (Table 7) to derive patient outcome

predictor scores scaled and normalized on a data range of 0-100 points. T-tests were used to

evaluate the statistical significance of differences in POP scores between NED and PSA ( ) as

well as between PSA and SYS ( ) clinical groups (p<7 X l O 7 and p<l X 10 6, respectively).


clinical group using a 10-target sequence metagene (Table 9) to derive patient outcome predictor

scores scaled and normalized on a data range of 0-100 points. T-tests were used to evaluate the

statistical significance of differences in POP scores between 'recurrent' (i.e., 'SYS') and non-

recurrent (i.e., 'PSA' and 'NED') patient groups ( , p<4 X 10 KK


clinical group using a 4 1-target sequence metagene (Table 10) to derive patient outcome

predictor scores scaled and normalized on a data range of 0-100 points. T-tests were used to

evaluate the statistical significance of differences in POP scores between 'recurrent' (i.e., 'SYS')

and non-recurrent (i.e., 'PSA' and 'NED') patient groups ( , p<2 X 10 ").


clinical group using a 148-target sequence metagene to derive patient outcome predictor scores

scaled and normalized on a data range of 0-100 points. T-tests were used to evaluate the

statistical significance of differences in POP scores between 'recurrent' (i.e., 'SYS') and non

recurrent (i.e., 'PSA' and 'NED') patient groups ( , p<9 X 10 12 ) .

DETAILED DESCRIPTION OF THE INVENTION

The present invention provides a system and method for assessing prostate cancer recurrence risk

by distinguishing clinically distinct disease states in men with prostate cancer at the time of

initial diagnosis or surgery. The system and methods are based on the identification of gene

transcripts following a retrospective analysis of tumor samples that are differentially expressed in

prostate cancer in a manner dependent on prostate cancer aggressiveness as indicated by long-

term post-prostatectomy clinical outcome. These gene transcripts can be considered as a library

which can be used as a resource for the identification of sets of specific target sequences

("prostate cancer prognostic sets"), which may represent the entire library of gene transcripts or a

subset of the library and the detection of which is indicative of prostate cancer recurrence risk.

The invention further provides for probes capable of detecting these target sequences and

primers that are capable of amplifying the target sequences.

In accordance with one embodiment of the invention, the system and method for assessing

prostate cancer recurrence risk are prognostic for a post surgery clinical outcome selected from

no evidence of disease ('NED'), biochemical relapse (two successive increases in prostate-

specific antigen levels; ('PSA') and systemic prostate cancer systemic metastases ('SYS').

In accordance with one embodiment of the invention, the target sequences comprised by the

prostate cancer prognostic set are sequences based on or derived from the gene transcripts from

the library, or a subset thereof. Such sequences are occasionally referred to herein as "probe

selection regions" or "PSRs." In another embodiment of the invention, the target sequences

comprised by the prostate classification set are sequences based on the gene transcripts from the

library, or a subset thereof, and include both coding and non-coding sequences.

In one embodiment, the systems and methods provide for the molecular analysis of the

expression levels of one or more of the target sequences as set forth in SEQ ID NOs: 1-21 14

(Table 4). Increased relative expression of one or more target sequences in a 'NED' Group

corresponding to the sequences as set forth in SEQ ID NOs: 1-913 is indicative of or predictive

of a non-recurrent form of prostate cancer and can be correlated with an increased likelihood of a

long-term NED prognosis or low risk of prostate cancer recurrence. Increased relative

expression of one or more target sequences in a 'SYS' Group corresponding to the sequences as

set forth in SEQ ID NOs: 914-21 14 is indicative of or predictive of an aggressive form of

prostate cancer and can be correlated with an increased likelihood of a long-term SYS prognosis

or high risk of prostate cancer recurrence. Optionally, intermediate relative levels of one or more

target sequences in a 'PSA' Group corresponding to target sequences set forth in Table 7 is

indicative of or predictive of biochemical recurrence. Subsets and combinations of these target

sequences or probes complementary thereto may be used as described herein.

Before the present invention is described in further detail, it is to be understood that this

invention is not limited to the particular methodology, compositions, articles or machines

described, as such methods, compositions, articles or machines can, of course, vary. It is also to

be understood that the terminology used herein is for the purpose of describing particular

embodiments only, and is not intended to limit the scope of the present invention.

DEFINITIONS

Unless defined otherwise or the context clearly dictates otherwise, all technical and scientific

terms used herein have the same meaning as commonly understood by one of ordinary skill in

the art to which this invention belongs. In describing the present invention, the following terms

will be employed, and are intended to be defined as indicated below.

The term "polynucleotide" as used herein refers to a polymer of greater than one nucleotide in

length of ribonucleic acid (RNA), deoxyribonucleic acid (DNA), hybrid RNA/DNA, modified

RNA or DNA, or RNA or DNA mimetics, including peptide nucleic acids (PNAs). The

polynucleotides may be single- or double- stranded. The term includes polynucleotides composed

of naturally-occurring nucleobases, sugars and covalent internucleoside (backbone) linkages as

well as polynucleotides having non-naturally-occurring portions which function similarly. Such

modified or substituted polynucleotides are well-known in the art and for the purposes of the

present invention, are referred to as "analogues."

"Complementary" or "substantially complementary" refers to the ability to hybridize or base pair

between nucleotides or nucleic acids, such as, for instance, between a sensor peptide nucleic acid

or polynucleotide and a target polynucleotide. Complementary nucleotides are, generally, A and

T (or A and U), or C and G . Two single-stranded polynucleotides or PNAs are said to be

substantially complementary when the bases of one strand, optimally aligned and compared and

with appropriate insertions or deletions, pair with at least about 80% of the bases of the other

strand, usually at least about 90% to 95%, and more preferably from about 98 to 100%.

Alternatively, substantial complementarity exists when a polynucleotide will hybridize under

selective hybridization conditions to its complement. Typically, selective hybridization will

occur when there is at least about 65% complementarity over a stretch of at least 14 to 25 bases,

for example at least about 75%, or at least about 90% complementarity. See, M . Kanehisa

Nucleic Acids Res. 12:203 ( 1984).

"Preferential binding" or "preferential hybridization" refers to the increased propensity of one

polynucleotide to bind to its complement in a sample as compared to a noncomplementary

polymer in the sample.

Hybridization conditions will typically include salt concentrations of less than about IM, more

usually less than about 500 mM, for example less than about 200 mM. In the case of

hybridization between a peptide nucleic acid and a polynucleotide, the hybridization can be done

in solutions containing little or no salt. Hybridization temperatures can be as low as 50C, but are

typically greater than 220C, and more typically greater than about 3O0C, for example in excess of

about 370C . Longer fragments may require higher hybridization temperatures for specific

hybridization as is known in the art. Other factors may affect the stringency of hybridization,

including base composition and length of the complementary strands, presence of organic

solvents and extent of base mismatching, and the combination of parameters used is more

important than the absolute measure of any one alone. Other hybridization conditions which

may be controlled include buffer type and concentration, solution pH, presence and

concentration of blocking reagents to decrease background binding such as repeat sequences or

blocking protein solutions, detergent type(s) and concentrations, molecules such as polymers

which increase the relative concentration of the polynucleotides, metal ion(s) and their

concentration(s), chelator(s) and their concentrations, and other conditions known in the art.

"Multiplexing" herein refers to an assay or other analytical method in which multiple analytes

can be assayed simultaneously.

A "target sequence" as used herein (also occasionally referred to as a "PSR" or "probe selection

region") refers to a region of the genome against which one or more probes can be designed. As

used herein, a probe is any polynucleotide capable of selectively hybridizing to a target sequence

or its complement, or to an RNA version of either. A probe may comprise ribonucleotides,

deoxyribonucleotides, peptide nucleic acids, and combinations thereof. A probe may optionally

comprise one or more labels. In some embodiments, a probe may be used to amplify one or both

strands of a target sequence or an RNA form thereof, acting as a sole primer in an amplification

reaction or as a member of a set of primers.

"Having" is an open ended phrase like "comprising" and "including," and includes

circumstances where additional elements are included and circumstances where they are not.

"Optional" or "optionally" means that the subsequently described event or circumstance may or

may not occur, and that the description includes instances where the event or circumstance

occurs and instances in which it does not.

As used herein 'NED' describes a clinically distinct disease state in which patients show no

evidence of disease ('NED') at least 5 years after surgery, 'PSA' describes a clinically distinct

disease state in which patients show biochemical relapse only (two successive increases in

prostate-specific antigen levels but no other symptoms of disease with at least 5 years follow up

after surgery; 'PSA') and 'SYS' describes a clinically distinct disease state in which patients

develop biochemical relapse and present with systemic prostate cancer disease or metastases

('SYS') within five years after the initial treatment with radical prostatectomy.

As used herein, the term "about" refers to approximately a +/-10% variation from a given value.

It is to be understood that such a variation is always included in any given value provided herein,

whether or not it is specifically referred to.

Use of the singular forms "a," "an," and "the" include plural references unless the context clearly

dictates otherwise. Thus, for example, reference to "a polynucleotide" includes a plurality of

polynucleotides, reference to "a target" includes a plurality of such targets, reference to "a

normalization method" includes a plurality of such methods, and the like. Additionally, use of

specific plural references, such as "two," "three," etc., read on larger numbers of the same

subject, unless the context clearly dictates otherwise.

Terms such as "connected," "attached," "linked" and "conjugated" are used interchangeably

herein and encompass direct as well as indirect connection, attachment, linkage or conjugation

unless the context clearly dictates otherwise.

Where a range of values is recited, it is to be understood that each intervening integer value, and

each fraction thereof, between the recited upper and lower limits of that range is also specifically

disclosed, along with each subrange between such values. The upper and lower limits of any

range can independently be included in or excluded from the range, and each range where either,

neither or both limits are included is also encompassed within the invention. Where a value

being discussed has inherent limits, for example where a component can be present at a

concentration of from 0 to 100%, or where the pH of an aqueous solution can range from 1 to 14,

those inherent limits are specifically disclosed. Where a value is explicitly recited, it is to be

understood that values which are about the same quantity or amount as the recited value are also

within the scope of the invention, as are ranges based thereon. Where a combination is

disclosed, each subcombination of the elements of that combination is also specifically disclosed

and is within the scope of the invention. Conversely, where different elements or groups of

elements are disclosed, combinations thereof are also disclosed. Where any element of an

5 invention is disclosed as having a plurality of alternatives, examples of that invention in which

each alternative is excluded singly or in any combination with the other alternatives are also

hereby disclosed; more than one element of an invention can have such exclusions, and all

combinations of elements having such exclusions are hereby disclosed.

io PROSTATE CANCER PROGNOSTIC SYSTEM

The system of the present invention is based on the identification of a library of gene and RNA

transcripts that are differentially expressed in prostate cancer in a manner dependent on prostate

cancer aggressiveness as indicated by the post-prostatectomy clinical outcome of the patient. For

15 example, relative over expression of one or more of the gene transcripts in a prostate cancer

sample compared to a reference sample or expression profile or signature there from may be

prognostic of a clinically distinct disease outcome post-prostatectomy selected from no evidence

of disease ('NED'), biochemical relapse ('PSA') and prostate cancer disease systemic recurrence

or metastases ('SYS') . The reference sample can be, for example, from prostate cancer

0 sample(s) of one or more references subject(s) with a known post-prostatectomy clinical

outcomes. The reference expression profile or signature may optionally be normalized to one or

more appropriate reference gene transcripts. Alternatively or in addition to, expression of one or

more of the gene transcripts in a prostate cancer sample may be compared to an expression

profile or signature from normal prostate tissue.

5

Expression profiles or signatures from prostate cancer samples may be normalized to one or

more house keeping gene transcripts such that normalized over and/or under expression of one or

more of the gene transcripts in a sample may be indicative of a clinically distinct disease state or

prognosis.

0

PROSTATE PROGNOSTIC LIBRARY

The Prostate Prognostic Library in accordance with the present invention comprises one or more

gene or RNA transcripts whose relative and/or normalized expression is indicative of prostate

cancer recurrence and which may be prognostic for post-prostatectomy clinical outcome of a

patient. Exemplary RNA transcripts that showed differential expression in prostate cancer

samples from patients with clinically distinct disease outcomes after initial treatment with radical

prostatectomy are shown in Table 3 . In one embodiment of the invention, the library comprises

one or more of the gene transcripts of the genes listed in Table 3 .

In one embodiment, the library comprises at least one transcript from at least one gene selected

from those listed in Table 3 . In one embodiment, the library comprises at least one transcript

from each of at least 5 genes selected from those listed in Table 3 . In another embodiment, the

library comprises at least one transcript from each of at least 10 genes selected from those listed

in Table 3 . In a further embodiment, the library comprises at least one transcript from each of at

least 15 genes selected from those listed in Table 1. In other embodiments, the library comprises

at least one transcript from each of at least 20, at least 25, at least 30, at least 35, at least 40, at

least 45, at least 50, at least 55, at least 60 and at least 65 genes selected from those listed in

Table 3 . In a further embodiment, the library comprises at least one transcript from all of the

genes listed in Table 3 . In a further embodiment, the library comprises at all transcripts from all

of the genes listed in Table 3 .


from the group consisting of [NMJ)0 10047221 ; [NMJ)0 10055221; [NMJ)OlO 1367 11;

[NMJ)0 10335 171; [NM_ 1830491; [NM_2 125591; 5'-3' exoribonuclease 1; A kinase (PRKA)

anchor protein (yotiao) 9; AarF domain containing kinase 4; Abhydrolase domain containing 3;

Aconitase 1, soluble; Actinin, alpha 1; ADAM metallopeptidase domain 19 (meltrin beta);

Adaptor-related protein complex 1, gamma 2 subunit; Adenosine deaminase, RNA-specific, B2

(RED2 homolog rat); Adenylate cyclase 3; ADP-ribosylation factor GTPase activating protein 3;

ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited); ADP-

ribosylation factor-like 4D; Adrenergic, beta, receptor kinase 2; AF4/FMR2 family, member 3;

Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); Anaphase promoting

complex subunit 1; Ankyrin 3, node of Ranvier (ankyrin G); Ankyrin repeat domain 15; Ankyrin

repeat domain 28; Annexin Al; Annexin A2; Anterior pharynx defective 1 homolog B (C.

elegans);Anthrax toxin receptor 1; Antizyme inhibitor 1; Arachidonate 12-lipoxygenase, 12R

type; Arginine vasopressin receptor IA; Arginine-glutamic acid dipeptide (RE) repeats; ARP3

actin-related protein 3 homolog (yeast); Arrestin 3, retinal (X-arrestin); Arrestin domain

containing 1; Aryl hydrocarbon receptor interacting protein-like 1; Aryl hydrocarbon receptor

nuclear translocator; Ataxin 1; ATM/ATR-Substrate Chk2-Interacting Zn2+-finger protein;

ATPase, Class I, type 8B, member 1; ATPase, Na+/K+ transporting, alpha 1 polypeptide; ATP-

binding cassette, sub-family F (GCN20), member 1; Autism susceptibility candidate 2;

Baculoviral IAP repeat-containing 6 (apollon); Basonuclin 2; Brain-specific angiogenesis

inhibitor 3; Bromodomain containing 7 ; Bromodomain containing 8; Bromodomain PHD finger

transcription factor; BTB (POZ) domain containing 16; BTB (POZ) domain containing 7 ;

Calcium activated nucleotidase 1; Calcium binding protein P22; Calcium channel, voltage-

dependent, beta 4 subunit; Calcium channel, voltage-dependent, L type, alpha 1C subunit;

Calcium channel, voltage-dependent, L type, alpha ID subunit; Calcyclin binding protein;

Calmodulin 1 (phosphorylase kinase, delta); Calsyntenin 1; Carbonyl reductase 3; Cardiolipin

synthase 1; Carnitine palmitoyltransferase IA (liver); Casein kinase 1, delta; Casein kinase 1,

gamma 1; Casein kinase 1, gamma 3; Caspase 1, apoptosis-related cysteine peptidase

(interleukin 1, beta, convertase); CD 109 molecule; CD99 molecule-like 2; CDK5 regulatory

subunit associated protein 2; CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2;

Cell adhesion molecule 1; Cell division cycle and apoptosis regulator 1; Centrosomal protein

7OkDa; Chloride channel 3; Chromodomain helicase DNA binding protein 2; Chromodomain

helicase DNA binding protein 6; Chromodomain protein, Y-like 2; Chromosome 1 ORF 116;

Chromosome 1 ORF 52; Chromosome 10 ORF 118; Chromosome 12 ORF 30; Chromosome 13

ORF 23; Chromosome 16 ORF 45; Chromosome 18 ORF 1; Chromosome 18 ORF 1;

Chromosome 18 ORF 1; Chromosome 18 ORF 1; Chromosome 18 ORF 17; Chromosome 2

ORF 3; Chromosome 20 ORF 133; Chromosome 2 1 ORF 25; Chromosome 2 1 ORF 34;

Chromosome 22 ORF 13; Chromosome 3 ORF 26; Chromosome 5 ORF 3; Chromosome 5 ORF

33; Chromosome 5 ORF 35; Chromosome 5 ORF 39; Chromosome 7 ORF 13; Chromosome 7

ORF 42; Chromosome 9 ORF 3; Chromosome 9 ORF 94; Chromosome Y ORF 15B; Chymase

1, mast cell; Citrate lyase beta like; Class II, major histocompatibility complex, transactivator; C-

Maf-inducing protein; Coatomer protein complex, subunit alpha; Cofilin 2 (muscle); Coiled-coil

domain containing 50; Coiled-coil domain containing 7 ; Coiled-coil-helix-coiled-coil-helix

domain containing 4 ; Cold shock domain containing El, RNA-binding; Collagen, type XII,

alpha 1; Complement component 1, r subcomponent-like; Core-binding factor, runt domain,

alpha subunit 2; translocated to, 2; CREB binding protein (Rubinstein-Taybi syndrome); CTD

(carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2; CTD

(carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like; CUG

triplet repeat, RNA binding protein 2; Cullin 3; Cut-like 2; Cyclin F; Cyclin Y; Cysteine-rich

with EGF-like domains 1; Cytochrome P450, family 4, subfamily F, polypeptide 11;

Cytoplasmic FMRl interacting protein 2; DAZ interacting protein 1-like; DCP2 decapping

enzyme homolog (S. cerevisiae); DEAD box polypeptide 47; DEAD box polypeptide 5; DEAD

box polypeptide 52; DEAD box polypeptide 56; Death inducer-obliterator 1; Dedicator of

cytokinesis 2; DEP domain containing IB; DEP domain containing 2; DEP domain containing 6;

Development and differentiation enhancing factor 1; Diacylglycerol lipase, alpha; Diaphanous

homolog 2 (Drosophila); Dickkopf homolog 3; Dihydropyrimidine dehydrogenase; Dipeptidyl-

peptidase 10; Discs, large homolog 2, chapsyn-1 10; Dishevelled, dsh homolog 2; DnaJ (Hsp40)

homolog, subfamily C, member 6; Dpy-19-like 3; Dual specificity phosphatase 5; Ectodysplasin

A receptor; Ectonucleoside triphosphate diphosphohydrolase 7 ; EGFR-coamplified and

overexpressed protein; ELL associated factor 1; Emopamil binding protein (sterol isomerase);

Enabled homolog; Ephrin-A5; ER lipid raft associated 1; Erythroblast membrane-associated

protein (Scianna blood group); Erythrocyte membrane protein band 4 .1 like 4A; Etoposide

induced 2.4 mRNA; Eukaryotic translation initiation factor 4E family member 3; FADl flavin

adenine dinucleotide synthetase homolog; Family with sequence similarity 110, member A;

Family with sequence similarity 114, member A l ; Family with sequence similarity 135, member

A; Family with sequence similarity 40, member A; Family with sequence similarity 80, member

B; F-box and leucine-rich repeat protein 11; F-box and leucine-rich repeat protein 7 ; F-box

protein 2; Ferritin, heavy polypeptide 1; Fibronectin type III domain containing 3A; Fibronectin

type III domain containing 3B; Fibulin 1; FLJ25476 protein; FLJ41603 protein; Forkhead box

J3; Forkhead box J3; Forkhead box Kl; Forkhead box P l ; Frizzled homolog 3; Frizzled homolog

5; G protein-coupled receptor kinase interactor 2; GABA A receptor, delta; GATA binding

protein 2; GDNF family receptor alpha 2; Gelsolin (amyloidosis, Finnish type); Genethonin 1;

Glucose phosphate isomerase; Glucose-fructose oxidoreductase domain containing 1;

Glucosidase, beta (bile acid) 2; Glutamate dehydrogenase 1; Glutaminase; Glutamyl

aminopeptidase (aminopeptidase A); Glutathione reductase

Glycogen synthase kinase 3 beta; Grainyhead-like 2; Gremlin 1, cysteine knot superfamily,

homolog; GTPase activating protein (SH3 domain) binding protein 1; Hairy/enhancer-of-split

related with YRPW motif 2; Heparan sulfate 6-O-sulfotransferase 3; Hermansky-Pudlak

syndrome 5; Heterogeneous nuclear ribonucleoprotein C (C1/C2)

Hippocalcin-like 1; Histocompatibility (minor) 13; Histone cluster 1, H3d; Histone deacetylase

6; Homeobox A l ; Homeobox and leucine zipper encoding; Host cell factor C l (VP16-accessory

protein); Hyaluronan binding protein 4 ; Hyperpolarization activated cyclic nucleotide-gated

potassium channel 3; Hypothetical gene supported by AK128346; Hypothetical LOC5 1149;

Hypothetical protein FLJ 12949; Hypothetical protein FLJ20035; Hypothetical protein FLJ20309;

Hypothetical protein FLJ38482; Hypothetical protein HSPC 148; Hypothetical protein

LOC 130576; Hypothetical protein LOC285908; Hypothetical protein LOC643 155; Iduronidase,

alpha-L- IKAROS family zinc finger 1 (Ikaros); HvB (bacterial acetolactate synthase)-like;

Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; Inositol

polyphosphate-4-phosphatase, type II; Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of

VLA-4 receptor); Integrin, alpha 6; Integrin, alpha 9; Integrin, alpha V (vitronectin receptor,

alpha polypeptide, antigen CD51); Integrin, beta-like 1 (with EGF-like repeat domains); Inter-

alpha (globulin) inhibitor H3; Interleukin enhancer binding factor 3, 9OkDa; Intestine- specific

homeobox

Intraflagellar transport 172 homolog; Janus kinase 1; Jumonji domain containing IB; Jumonji

domain containing 2B; Jumonji domain containing 2C; Kalirin, RhoGEF kinase; Kallikrein-

related peptidase 2; Karyopherin alpha 3 (importin alpha 4); Keratinocyte associated protein 2;

KIAAO 152; KIAA0241 ; KIAA03 19-like; KIAA0495; KIAA0562; KIAA0564 protein;

KIAAl 217; KIAA 1244; KIAA 1244; La ribonucleoprotein domain family, member 1; Lamin

A/C; LATS, large tumor suppressor, homolog 2; Leiomodin 3 (fetal); Leptin receptor

overlapping transcript-like 1; Leucine rich repeat containing 16; Leucine-rich repeat kinase 1;

Leucine-rich repeat-containing G protein-coupled receptor 4 ; LIM domain 7; Major

histocompatibility complex, class II, DR beta 1; Malignant fibrous histiocytoma amplified

sequence 1; Maltase-glucoamylase (alpha-glucosidase); Mannosidase, alpha, class 2A, member

1; Mannosyl (alpha- 1,6-)-glycoprotein beta-l,6-N-acetyl-glucosaminyltransferase; MBD2-

interacting zinc finger; Melanin-concentrating hormone receptor 1; Methionyl-tRNA synthetase;

Methyl CpG binding protein 2; Methyl-CpG binding domain protein 5; Microcephaly, primary

autosomal recessive 1; Microseminoprotein, beta-; Microtubule-associated protein IB;

Microtubule-associated protein 2; Minichromosome maintenance complex component 3

associated protein; Mitochondrial ribosomal protein S 15; Mohawk homeobox; Monooxygenase,

DBH-like 1; MORN repeat containing 1; Muscle RAS oncogene homolog; Muscleblind-like;

Myelin protein zero-like 1; Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog,

Drosophila); translocated to, 4; Myocyte enhancer factor 2B; Myosin IF; Myosin, heavy chain 3,

skeletal muscle, embryonic; N-acetylgalactosaminidase, alpha-; N-acetylglucosamine-1-

phosphate transferase, alpha and beta subunits; Nascent polypeptide-associated complex alpha

subunit; NECAP endocytosis associated 2; Necdin homolog; Neural precursor cell expressed,

developmentally down-regulated 9; Neuregulin 1 ; Neuron navigator 1 ; Nibrin ; Nicotinamide

N-methyltransferase ; NIMA (never in mitosis gene a)-related kinase 6; NLR family, CARD

domain containing 5; NOLl/NOP2/Sun domain family, member 3; NOLl/NOP2/Sun domain

family, member 3; NOLl/NOP2/Sun domain family, member 6; Nuclear receptor coactivator 2;

Nuclear receptor coactivator 6;Nuclear receptor subfamily 2, group F, member 2; Nuclear

receptor subfamily 3, group C, member 2; Nuclear receptor subfamily 4, group A, member 2;

Nuclear transcription factor, X-box binding-like 1; Nucleolar and coiled-body phosphoprotein 1;

Overexpressed in colon carcinoma- 1; PAN3 polyA specific ribonuclease subunit homolog; PAP

associated domain containing 1; Paraoxonase 2; Paraspeckle component 1 ; PCTAIRE protein

kinase 2; Peptidase D; Pericentrin (kendrin); Peroxisomal biogenesis factor 19; PHD finger

protein 8; Phosphatidic acid phosphatase type 2 domain containing 3; Phosphatidylinositol 4-

kinase, catalytic, alpha polypeptide; Phosphatidylinositol glycan anchor biosynthesis, class O;

Phosphatidylinositol transfer protein, beta; Phosphodiesterase 4D, cAMP-specific;

Phosphoglucomutase 5; Phosphoglycerate mutase family member 5; Phosphoinositide-3-kinase,

class 2, beta polypeptide; Phospholipase A2, group IVB (cytosolic); Phospholipase C, beta 1

(phosphoinositide-specific); Phospholipase C, gamma 2 (phosphatidylinositol-

specific);Phosphorylase kinase, beta; Plasminogen activator, tissue; Platelet-activating factor

acetylhydrolase, isoform Ib, alpha subunit 45kDa; Pleckstrin homology domain containing,

family A (phosphoinositide binding specific) member 3; Pleckstrin homology domain

containing, family A member 7 ; Pleckstrin homology domain containing, family G (with RhoGef

domain) member 3; Pleckstrin homology domain containing, family H (with MyTH4 domain)

member 1; Poly (ADP-ribose) polymerase family, member 16; Poly (ADP-ribose) polymerase

family, member 2; PoIy(A) polymerase alpha; Poly(A)-specific ribonuclease (deadenylation

nuclease); Polymerase (DNA directed) nu; Polymerase (DNA directed), gamma 2, accessory

subunit; Polymerase (RNA) II (DNA directed) polypeptide L; Polymerase (RNA) III (DNA

directed) polypeptide E; Polymerase I and transcript release factor; Potassium channel

tetramerisation domain containing 1; Potassium channel tetramerisation domain containing 2;

Potassium channel tetramerisation domain containing 7 ; Potassium channel, subfamily K,

member 1;Presenilin 1; PRKR interacting protein 1; Procollagen-lysine, 2-oxoglutarate 5-

dioxygenase 2; ProSAPiPl protein; Prostaglandin E synthase 3 (cytosolic); Protease, serine, 2

(trypsin 2); Protein kinase, Y-linked; Protein phosphatase 1, regulatory (inhibitor) subunit 9A;

Protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform; Protein phosphatase 4,

regulatory subunit 1-like; Protein tyrosine phosphatase, non-receptor type 18 (brain-derived);

Protein tyrosine phosphatase, non-receptor type 3; Protein tyrosine phosphatase, receptor type,

D; Protein-O-mannosyltransferase 1; Proteolipid protein 2 (colonic epithelium-enriched);

Protocadherin 7 ; Protocadherin gamma subfamily A, 1; PRP6 pre-mRNA processing factor 6

homolog; Putative homeodomain transcription factor 1; RAB GTPase activating protein 1-like;

RAB lO; RAB30; Rabaptin, RAB GTPase binding effector protein 1; RAD51-like 1; RALBPl

associated Eps domain containing 2; Rap guanine nucleotide exchange factor (GEF) 1;

Rapamycin-insensitive companion of mTOR; Ras and Rab interactor 2; Receptor accessory

protein 3; Reelin; Replication factor C (activator 1) 3; Replication protein A3; Rho GTPase

activating protein 18; Rho guanine nucleotide exchange factor (GEF) 10-like; Rhophilin, Rho

GTPase binding protein 1; Ribonuclease H2, subunit B; Ribonuclease P 14kDa subunit; Ring

finger protein 10; Ring finger protein 144; Ring finger protein 44; RNA binding motif protein

16; Roundabout, axon guidance receptor, homolog 1; Roundabout, axon guidance receptor,

homolog 2; RUN domain containing 2A; Scinderin; SEC23 interacting protein; Secό l alpha 2

subunit; Septin 11; Serine/threonine kinase 32A; Serine/threonine kinase 32C; SGTl, suppressor

of G2 allele of SKPl; SH3 and PX domains 2A; Signal peptide peptidase 3; Signal transducer

and activator of transcription 1, 9IkDa; Single- stranded DNA binding protein 2; Small nuclear

ribonucleoprotein polypeptide N; SNF8, ESCRT-II complex subunit, homolog; Sodium channel,

voltage- gated, type III, alpha subunit; Solute carrier family 1 (neutral amino acid transporter),

member 5; Solute carrier family 16, member 7 (monocarboxylic acid transporter 2); Solute

carrier family 2 (facilitated glucose transporter), member 11; Solute carrier family 2 (facilitated

glucose transporter), member 11; Solute carrier family 24 (sodium/potassium/calcium

exchanger), member 3; Solute carrier family 3 (activators of dibasic and neutral amino acid

transport), member 2; Solute carrier family 30 (zinc transporter), member 6; Solute carrier family

39 (zinc transporter), member 10; Solute carrier family 43, member 1; Solute carrier family 9

(sodium/hydrogen exchanger), member 3 regulator 2; SON DNA binding protein; Sortilin-

related VPSlO domain containing receptor 3; Sparc/osteonectin, cwcv and kazal-like domains

proteoglycan (testican) 2; Spectrin repeat containing, nuclear envelope 1; Sperm associated

antigen 9; Splicing factor 3a, subunit 2, 66kDa; Splicing factor 3b, subunit 1, 155kDa;

Staphylococcal nuclease and tudor domain containing 1; Staufen, RNA binding protein, homolog

1; Suppression of tumorigenicity 7; Suppressor of variegation 4-20 homolog 1; Synapsin III;

Syntaxin 3; Syntaxin 5; Tachykinin receptor 1; TAO kinase 3; TBCl domain family, member

16; TBCl domain family, member 19; Testis specific, 10; Tetraspanin 6; Tetratricopeptide repeat

domain 23; Thioredoxin-like 2; THUMP domain containing 3; TIMELESS interacting protein;

TOX high mobility group box family member 4; Trafficking protein, kinesin binding 1;

Transcription factor 7-like 1 (T-cell specific, HMG-box); Transcription factor 7-like 2 (T-cell

specific, HMG-box); Translocase of inner mitochondrial membrane 13 homolog; Translocated

promoter region (to activated MET oncogene); Translocation associated membrane protein 2;

Transmembrane 9 superfamily member 2; Transmembrane emp24 protein transport domain

containing 8; Transmembrane emp24-like trafficking protein 10; Transmembrane protein 134;

Transmembrane protein 18; Transmembrane protein 18; Transmembrane protein 29; Triadin;

Tribbles homolog 1; Trinucleotide repeat containing 6C; Tripartite motif-containing 36;

Tripartite motif-containing 6 1; TRNA methyltransferase 11 homolog; TruB pseudouridine (psi)

synthase homolog 2; Tubby like protein 4; Tuftelin 1; Tumor necrosis factor receptor

superfamily, member l ib (osteoprotegerin); Tumor necrosis factor receptor superfamily,

member 25; Tumor necrosis factor, alpha-induced protein 8; Tyrosine kinase 2; Ubiquinol-

cytochrome c reductase core protein I ; Ubiquitin specific peptidase 47; Ubiquitin specific

peptidase 5 (isopeptidase T); Ubiquitin specific peptidase 8; Ubiquitin-like 7 (bone marrow

stromal cell-derived); UBX domain containing 6; UDP-glucose ceramide glucosyltransferase-

like 2; UDP-N-acetyl-alpha-D-galactosamineipolypeptide N-acetylgalactosaminyltransferase 2

(GalNAc-T2); Unc-93 homolog B 1;UTP6, small subunit (SSU) processome component,

homolog; Vacuolar protein sorting 8 homolog; V-akt murine thymoma viral oncogene homolog

1; V-ets erythroblastosis virus E26 oncogene homolog; Viral DNA polymerase-transactivated

protein 6; WD repeat domain 33; WD repeat domain 90; Wingless-type MMTV integration site

family, member 2B; WW and C2 domain containing 1; Yipl domain family, member 3; YTH

domain family, member 3; Zinc finger and BTB domain containing 10; Zinc finger and BTB

domain containing 20; Zinc finger and SCAN domain containing 18; Zinc finger homeodomain

4 ; Zinc finger protein 14 homolog; Zinc finger protein 335; Zinc finger protein 394; Zinc finger

protein 407 ; Zinc finger protein 608; Zinc finger protein 667; Zinc finger protein 692; Zinc

finger protein 718; Zinc finger protein 72 1; Zinc finger, CCHC domain containing 9; Zinc finger,

matrin type 1; Zinc finger, MYND domain containing 11; Zinc finger, ZZ-type containing 3;

Zinc fingers and homeoboxes 2; and Zwilch, kinetochore associated, homolog.


from the group consisting of Replication factor C (activator 1) 3; Tripartite motif-containing 61;

Citrate lyase beta like; Ankyrin repeat domain 15; UDP-glucose ceramide glucosyltransferase-

like 2; Hypothetical protein FLJ 12949; Chromosome 22 open reading frame 13;

Phosphatidylinositol glycan anchor biosynthesis, class O; Solute carrier family 43, member 1;

Rabaptin, RAB GTPase binding effector protein 1; Zinc finger protein 14 homolog; Hypothetical

gene supported by AK 128346; Adenylate cyclase 3; Phosphatidylinositol transfer protein, beta;

Zinc finger protein 667; Gremlin 1, cysteine knot superfamily, homolog; Ankyrin 3, node of

Ranvier (ankyrin G) and Maltase-glucoamylase (alpha-glucosidase).


from the group consisting of Replication factor C (activator 1) 3; Ankyrin repeat domain 15;

Hypothetical protein FLJ 12949; Solute carrier family 43, member 1; Thioredoxin-like 2;

Polymerase (RNA) II (DNA directed) polypeptide L; Syntaxin 5; Leucine rich repeat containing

16; Calcium channel, voltage-dependent, beta 4 subunit; [NM_00 1005522]; G protein-coupled

receptor kinase interactor 2; Ankyrin 3, node of Ranvier (ankyrin G); Gremlin 1, cysteine knot

superfamily, homolog; Zinc finger protein 667; Hypothetical gene supported by AKl 28346;

Transmembrane 9 superfamily member 2; Potassium channel, subfamily K, member 1;

Chromodomain helicase DNA binding protein 2; Microcephaly, primary autosomal recessive 1;

Chromosome 2 1 open reading frame 34 and Dual specificity phosphatase 5 .



Citrate lyase beta like; Ankyrin repeat domain 15; Ankyrin 3, node of Ranvier (ankyrin G) and

Maltase-glucoamylase (alpha-glucosidase).


from the group consisting of Replication factor C (activator 1) 3; Ankyrin repeat domain 15;

Hypothetical protein FLJ 12949; Solute carrier family 43, member 1; Thioredoxin-like 2;

Polymerase (RNA) II (DNA directed) polypeptide L; Syntaxin 5; Leucine rich repeat containing

16; Calcium channel, voltage-dependent, beta 4 subunit; [NM_00 1005522]; G protein-coupled

receptor kinase interactor 2; Ankyrin 3, node of Ranvier (ankyrin G); Gremlin 1, cysteine knot

superfamily, homolog; Zinc finger protein 667; Hypothetical gene supported by AK 128346;

Transmembrane 9 superfamily member 2; Potassium channel, subfamily K, member 1;

Chromodomain helicase DNA binding protein 2; Chromosome 9 open reading frame 94;

Chromosome 2 1 open reading frame 34; and Dual specificity phosphatase 5 .


from the group consisting of Citrate lyase beta like; Phosphodiesterase 4D, cAMP-specific;

Ectodysplasin A receptor; DEP domain containing 6; Basonuclin 2; Chromosome 2 open reading

frame 3; FLJ25476 protein; Staphylococcal nuclease and tudor domain containing 1;

Hermansky-Pudlak syndrome 5 and Chromosome 12 open reading frame 30.



Citrate lyase beta like; Adaptor-related protein complex 1, gamma 2 subunit; Kallikrein-related

peptidase 2; Phosphodiesterase 4D, cAMP-specific; Cytochrome P450, family 4, subfamily F,

polypeptide 11; Ectodysplasin A receptor

Phospholipase C, beta 1; KIAA 1244; Paraoxonase 2; Arachidonate 12-lipoxygenase, 12R type;

Cut-like 2; Chemokine (C-X-C motif) ligand 12; Rho guanine nucleotide exchange factor (GEF)

5; Olfactory receptor, family 2, subfamily A, member 4; Chromosome 19 open reading frame 42;

Hypothetical gene supported by AK128346; Phosphoglucomutase 5; Hyaluronan binding protein

4 ; NECAP endocytosis associated 2

Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4 ; Signal transducer and activator

of transcription 1; Chromosome 2 open reading frame 3; FLJ25476 protein; Staphylococcal

nuclease and tudor domain containing 1; Transmembrane protein 18; Hermansky-Pudlak

syndrome 5; Chromosome 12 open reading frame 30; Splicing factor 3b, subunit 1; Cofilin 2;

Heparan sulfate 6-O-sulfotransferase 3; Enabled homolog; Mannosyl (alpha- 1,6-)-glycoprotein

beta- 1,6-N-acetyl-glucosaminyltransferase; Solute carrier family 24 (sodium/potassium/calcium

exchanger), member 3; Inositol 1,4,5-triphosphate receptor, type 1; CAP-GLY domain

containing linker protein; Transglutaminase 4 ; MOCO sulphurase C-terminal domain containing

2; 4-hydroxyphenylpyruvate dioxygenase-like; and R3H domain containing 1.

The invention also contemplates that alternative libraries may be designed that include

transcripts of one or more of the genes in Table 3, together with additional gene transcripts that

have previously been shown to be associated with prostate cancer systemic progression. As is

known in the art, the publication and sequence databases can be mined using a variety of search

strategies to identify appropriate additional candidates for inclusion in the library. For example,

currently available scientific and medical publication databases such as Medline, Current

Contents, OMIM (online Mendelian inheritance in man), various Biological and Chemical

Abstracts, Journal indexes, and the like can be searched using term or key-word searches, or by

author, title, or other relevant search parameters. Many such databases are publicly available, and

strategies and procedures for identifying publications and their contents, for example, genes,

other nucleotide sequences, descriptions, indications, expression pattern, etc, are well known to

those skilled in the art. Numerous databases are available through the internet for free or by

subscription, see, for example, the National Center Biotechnology Information (NCBI),

Infotrieve, Thomson ISI, and Science Magazine (published by the AAAS) websites. Additional

or alternative publication or citation databases are also available that provide identical or similar

types of information, any of which can be employed in the context of the invention. These

databases can be searched for publications describing altered gene expression between recurrent

and non-recurrent prostate cancer. Additional potential candidate genes may be identified by

searching the above described databases for differentially expressed proteins and by identifying

the nucleotide sequence encoding the differentially expressed proteins. A list of genes whose

altered expression is between patients with recurrent disease and non-recurrent prostate cancer is

presented in Table 6 .

PROSTATE CANCER PROGNOSTIC SETS

A Prostate Prognostic Set comprises one or more target sequences identified within the gene

transcripts in the prostate prognostic library, or a subset of these gene transcripts. The target

sequences may be within the coding and/or non-coding regions of the gene transcripts. The set

can comprise one or a plurality of target sequences from each gene transcript in the library, or

subset thereof. The relative and/or normalized level of these target sequences in a sample is

indicative of the level of expression of the particular gene transcript and thus of prostate cancer

recurrence risk. For example, the relative and/or normalized expression level of one or more of

the target sequences may be indicative of an recurrent form of prostate cancer and therefore

prognostic for prostate cancer systemic progression while the relative and/or normalized

expression level of one or more other target sequences may be indicative of a non-recurrent form

of prostate cancer and therefore prognostic for a NED clinical outcome.

Accordingly, one embodiment of the present invention provides for a library or catalog of

candidate target sequences derived from the transcripts (both coding and non-coding regions) of

at least one gene suitable for classifying prostate cancer recurrence risk. In a further embodiment,

the present invention provides for a library or catalog of candidate target sequences derived from

the non-coding regions of transcripts of at least one gene suitable for classifying prostate cancer

recurrence risk. In still a further embodiment, the library or catalog of candidate target

sequences comprises target sequences derived from the transcripts of one or more of the genes

set forth in Table 3 and/or Table 6 . The library or catalog in affect provides a resource list of

transcripts from which target sequences appropriate for inclusion in a Prostate Cancer Prognostic

set can be derived. In one embodiment, an individual Prostate Cancer Prognostic set may

comprise target sequences derived from the transcripts of one or more genes exhibiting a positive

correlation with recurrent prostate cancer. In one embodiment, an individual Prostate Cancer

Prognostic Set may comprise target sequences derived from the transcripts of one or more genes

exhibiting a negative correlation with recurrent prostate cancer. In one embodiment, an

individual Prostate Cancer Prognostic Set may comprise target sequences derived from the

transcripts of two or more genes, wherein at least one gene has a transcript that exhibits a

positive correlation with recurrent prostate cancer and at least one gene has a transcript that

exhibits negative correlation with recurrent prostate cancer.

In one embodiment, the Prostate Cancer Prognostic Set comprises target sequences derived from

the transcripts of at least one gene. In one embodiment, the Prostate Cancer Prognostic Set

comprises target sequences derived from the transcripts of at least 5 genes. In another

embodiment, the Prostate Cancer Prognostic set comprises target sequences derived from the

transcripts of at least 10 genes. In a further embodiment, the Prostate Cancer Prognostic set

comprises target sequences derived from the transcripts of at least 15 genes. In other

embodiments, the Prostate Cancer Prognostic set comprises target sequences derived from the

transcripts of at least 20, at least 25, at least 30, at least 35, at least 40, at least 45, at least 50, at

least 55, at least 60 and at least 65 genes.

Following the identification of candidate gene transcripts, appropriate target sequences can be

identified by screening for target sequences that have been annotated to be associated with each

specific gene locus from a number of annotation sources including GenBank, RefSeq, Ensembl,

dbEST, GENSCAN, TWINSCAN, Exoniphy, Vega, microRNAs registry and others (see

Affymetrix Exon Array design note).

As part of the target sequence selection process, target sequences can be further evaluated for

potential cross-hybridization against other putative transcribed sequences in the design (but not

the entire genome) to identify only those target sequences that are predicted to uniquely

hybridize to a single target.

Optionally, the set of target sequences that are predicted to uniquely hybridize to a single target

can be further filtered using a variety of criteria including, for example, sequence length, for their

mean expression levels across a wide selection of human tissues, as being representive of

transcripts expressed either as novel alternative (i.e., non-consensus) exons, alternative retained

introns, novel exons 5' or 3' of the gene's transcriptional start site or representing transcripts

expressed in a manner antisense to the gene, amongst others.

In one embodiment, the Prostate Classification Set comprises target sequences derived from

382,253 base pair 3' of Replication factor C (activator 1) 3, 38kDa; 58,123 base pair 3' of

Tripartite motif-containing 6 1; in intron #3 of Citrate lyase beta like; in intron #2 of Ankyrin

repeat domain 15; in exon # 1 of UDP-glucose ceramide glucosyltransferase-like 2; in exon of

#19 of Hypothetical protein FLJ 12949; in intron #4 of Chromosome 22 open reading frame 13;

in exon #2 of phatidylinositol glycan anchor biosynthesis, class O; in exon #15 of Solute carrier

family 43, member 1; in exon # 1 of Rabaptin, RAB GTPase binding effector protein 1; in intron

#38 of Maltase-glucoamylase (alpha-glucosidase); in intron #23 of Ankyrin 3, node of Ranvier

(ankyrin G); 71,333 base pair 3' of Gremlin 1, cysteine knot superfamily, homolog; 1,561 base

pair of 3' Zinc finger protein 667; in exon #4 of Phosphatidylinositol transfer protein, beta;

in intron #18 of Adenylate cyclase 3; and in exon #2 of Hypothetical gene supported by

AK 128346.


382,253 base pair 3' of Replication factor C (activator 1) 3; in intron #2 of Ankyrin repeat

domain 15; in exon #19 of Hypothetical protein FLJ 12949; in exon #15 of Solute carrier family

43, member 1; 313,721 base pair 3' of Thioredoxin-like 2; in exon #2 of Polymerase

(RNA) II (DNA directed) polypeptide L, 7.6kDa; in intron #10 of Syntaxin 5; 141,389 base pail¬

' of Leucine rich repeat containing 16; in intron #2 of Calcium channel, voltage-dependent, beta

4 subunit; 5,474 base pair 5' of [NM_00 1005522]; in intron #14 of G protein-coupled receptor

kinase interactor 2; in intron #23 of Ankyrin 3, node of Ranvier (ankyrin G); 71,333 base pair 3'

of Gremlin 1, cysteine knot superfamily, homolog; 1,561 base pair of 3' of Zinc finger protein

667; in exon #2 of Hypothetical gene supported by AKl 28346; in intron # 11 of Transmembrane

9 superfamily member 2; in intron # 1 of Potassium channel, subfamily K, member 1; in intron #2

of Chromodomain helicase DNA binding protein 2; 22,184 base pair 5' of Microcephaly,

primary autosomal recessive 1; in intron #4 of Chromosome 2 1 open reading frame 34; and in

intron #2 of Dual specificity phosphatase 5 .



Tripartite motif-containing 6 1; in intron #3 of Citrate lyase beta like; in intron #2 of Ankyrin

repeat domain 15; in intron #38 of Maltase-glucoamylase (alpha-glucosidase); and in intron #23

of Ankyrin 3, node of Ranvier (ankyrin G).


382,253 base pair 3' of Replication factor C (activator 1) 3, 38kDa; in intron #2 of Ankyrin

repeat domain 15; in exon #19 of Hypothetical protein FLJ12949; in exon #15 of Solute carrier

family 43, member 1; 3 13,721 base pair 3' of Thioredoxin-like 2; in exon #2 of Polymerase

(RNA) II (DNA directed) polypeptide L, 7.6kDa; in intron #10 of Syntaxin 5; 141,389 base pair

5' of Leucine rich repeat containing 16; in intron #2 of Calcium channel, voltage-dependent, beta

4 subunit; 5,474 base pair 5' of [NM_00 1005522]; in intron #14 of G protein-coupled receptor

kinase interactor 2; in intron #2 of Ankyrin 3, node of Ranvier (ankyrin G); 71,333 base pair of

3' Gremlin 1, cysteine knot superfamily; 1,561 base pair 3' of Zinc finger protein 667; in exon

#2 of Hypothetical gene supported by AKl 28346; in intron # 11 of Transmembrane 9

superfamily member 2; in intron # 1 of Potassium channel, subfamily K, member 1; in intron #2

of Chromodomain helicase DNA binding protein 2; in exon #8 of Chromosome 9 open reading

frame 94; in intron #4 of Chromosome 2 1 open reading frame 34; and

in intron #2 of Dual specificity phosphatase 5 .

In one embodiment, the Prostate Classification Set comprises target sequences derived from in

intron #3 of Citrate lyase beta like; 210,560 base pair 5' of Phosphodiesterase 4D; 189,722 base

pair 5' of Ectodysplasin A receptor; 3,5 10 base pair 3' of DEP domain containing 6; in exon #6

of Basonuclin 2; in intron # 1 of Chromosome 2 open reading frame 3; in intron # 1 of FLJ25476

protein; in intron #10 of Staphylococcal nuclease and tudor domain containing 1; in exon

#22 of Hermansky-Pudlak syndrome 5; and in exon #24 of Chromosome 12 open reading frame

30.



Tripartite motif-containing 61; in intron #3 of Citrate lyase beta like; in intron # 1 of Adaptor-

related protein complex 1, gamma 2 subunit; in intron #2 of Kallikrein-related peptidase 2;

210,560 base pair 5' of Phosphodiesterase 4D; 3,508 base pair 3' of Cytochrome P450, family 4,

subfamily F, polypeptide 11; 189,722 base pair 5' of Ectodysplasin A receptor; in intron #2 of

Phospholipase C, beta 1; in intron #10 of KIAAl 244; in intron #2 of Paraoxonase 2; 11,235 base

pair 3' of Arachidonate 12-lipoxygenase, 12R type; in exon #22 of Cut-like 2; 143,098 base pah

' of Chemokine (C-X-C motif) ligand 12; in intron #6 of Rho guanine nucleotide exchange

factor (GEF) 5; 15,057 base pair 5' of Olfactory receptor, family 2, subfamily A, member 4;

6,025 base pair 3' of Chromosome 19 open reading frame 42; in exon #2 of Hypothetical gene

supported by AK128346; in exon # 11 of Phosphoglucomutase 5; in exon #9 of Hyaluronan

binding protein 4; in exon #8 of NECAP endocytosis associated 2; in intron #20 of

Myeloid/lymphoid or mixed-lineage leukemia; 1,558 base pair 3' of Signal transducer and

activator of transcription; in intron # 1 of Chromosome 2 open reading frame 3; in intron # 1 of

FLJ25476 protein; in intron #10 of Staphylococcal nuclease and tudor domain containing 1;

84,468 base pair 3' of Transmembrane protein 18; in exon #22 of Hermansky-Pudlak syndrome

5; in exon #24 of Chromosome 12 open reading frame 30; 95,745 base pair of 3' Splicing factor

3b, subunit 1; in exon #4 of Cofilin 2; in intron # 1 of Heparan sulfate 6-O-sulfotransferase 3; in

intron # 1 of Enabled homolog ; in intron #2 of Mannosyl (alpha- 1,6-)-glycoprotein beta-l,6-N-

acetyl-glucosaminyltransferase; in intron #8 of Solute carrier family 24, member 3; 32,382 base

pair 3' of Inositol 1,4,5-triphosphate receptor, type 1; in intron #9 of CAP-GLY domain

containing linker protein 1; in exon #14 of Transglutaminase 4 ; in intron #4 of MOCO

sulphurase C-terminal domain containing 2; 21,555 base pair 5' of 4 hydroxyphenylpyruvate

dioxygenase-like; and in exon #26 of R3H domain containing 1.

In one embodiment, the potential set of target sequences can be filtered for their expression

levels using the multi-tissue expression data made publicly available by Affymetrix at

probes with, for example, elevated expression across numerous tissues (non-specific) or no

expression in prostate tissue can be excluded.

VALIDATION OF TARGET SEQUENCES

Following in silico selection of target sequences, each target sequence suitable for use in the

Prostate Cancer Prognostic Set may be validated to confirm differential relative or normalized

expression in recurrent prostate cancer or non-recurrent prostate cancer. Validation methods are

known in the art and include hybridization techniques such as microarray analysis or Northern

blotting using appropriate controls, and may include one or more additional steps, such as

reverse transcription, transcription, PCR, RT-PCR and the like. The validation of the target

sequences using these methods is well within the abilities of a worker skilled in the art.

MINIMAL EXPRESSION SIGNATURE

In one embodiment, individual Prostate Cancer Prognostic Sets provide for at least a

determination of a minimal expression signature, capable of distinguishing recurrent from non

recurrent forms of prostate cancer. Means for determining the appropriate number of target

sequences necessary to obtain a minimal expression signature are known in the art and include

the Nearest Shrunken Centroids (NSC) method.

In this method (see US 2007003 1873), a standardized centroid is computed for each class. This

is the average gene expression for each gene in each class divided by the within-class standard

deviation for that gene. Nearest centroid classification takes the gene expression profile of a new

sample, and compares it to each of these class centroids. The class whose centroid that it is

closest to, in squared distance, is the predicted class for that new sample. Nearest shrunken

centroid classification "shrinks" each of the class centroids toward the overall centroid for all

classes by an amount called the threshold. This shrinkage consists of moving the centroid

towards zero by threshold, setting it equal to zero if it hits zero. For example if threshold was 2.0,

a centroid of 3.2 would be shrunk to 1.2, a centroid of -3.4 would be shrunk to -1.4, and a

centroid of 1.2 would be shrunk to zero. After shrinking the centroids, the new sample is

classified by the usual nearest centroid rule, but using the shrunken class centroids. This

shrinkage can make the classifier more accurate by reducing the effect of noisy genes and

provides an automatic gene selection. In particular, if a gene is shrunk to zero for all classes, then

it is eliminated from the prediction rule. Alternatively, it may be set to zero for all classes except

one, and it can be learned that the high or low expression for that gene characterizes that class.

The user decides on the value to use for threshold. Typically one examines a number of different

choices. To guide in this choice, PAM does K-fold cross-validation for a range of threshold

values. The samples are divided up at random into K roughly equally sized parts. For each part in

turn, the classifier is built on the other K-I parts then tested on the remaining part. This is done

for a range of threshold values, and the cross-validated misclassification error rate is reported for

each threshold value. Typically, the user would choose the threshold value giving the minimum

cross-validated misclassification error rate.

Alternatively, minimal expression signatures can be established through the use of optimization

algorithms such as the mean variance algorithm widely used in establishing stock portfolios. This

method is described in detail in US patent publication number 20030194734. Essentially, the

method calls for the establishment of a set of inputs (stocks in financial applications, expression

as measured by intensity here) that will optimize the return (e.g., signal that is generated) one

receives for using it while minimizing the variability of the return. In other words, the method

calls for the establishment of a set of inputs (e.g., expression as measured by intensity) that will

optimize the signal while minimizing variability. Many commercial software programs are

available to conduct such operations. "Wagner Associates Mean-Variance Optimization

Application," referred to as "Wagner Software" throughout this specification, is preferred. This

software uses functions from the "Wagner Associates Mean-Variance Optimization Library" to

determine an efficient frontier and optimal portfolios in the Markowitz sense is preferred. Use of

this type of software requires that microarray data be transformed so that it can be treated as an

input in the way stock return and risk measurements are used when the software is used for its

intended financial analysis purposes.

The process of selecting a minimal expression signature can also include the application of

heuristic rules. Preferably, such rules are formulated based on biology and an understanding of

the technology used to produce clinical results. More preferably, they are applied to output from

the optimization method. For example, the mean variance method of portfolio selection can be

applied to microarray data for a number of genes differentially expressed in subjects with cancer.

Output from the method would be an optimized set of genes that could include some genes that

are expressed in peripheral blood as well as in diseased tissue.

Other heuristic rules can be applied that are not necessarily related to the biology in question. For

example, one can apply a rule that only a prescribed percentage of the portfolio can be

represented by a particular gene or group of genes. Commercially available software such as the

Wagner Software readily accommodates these types of heuristics. This can be useful, for

example, when factors other than accuracy and precision (e.g., anticipated licensing fees) have

an impact on the desirability of including one or more genes.

In one embodiment, the Prostate Cancer Prognostic Set for obtaining a minimal expression

signature comprises at least one, two, three, four, five, six, eight, 10, 15, 20, 25 or more of target

sequences shown to have a positive correlation with non-recurrent prostate disease, for example

those depicted in SEQ ID NOs: 1-913 or a subset thereof. In another embodiment, the Prostate

Cancer Prognostic Set for obtaining a minimal expression signature comprises at least one, two,

three, four, five, six, eight, 10, 15, 20, 25 or more of those target sequences shown to have a

positive correlation with recurrent prostate cancer, for example those depicted in of SEQ ID

NOs: 914-21 14, or a subset therof. In yet another embodiment, the Prostate Cancer Prognostic

Set for obtaining a minimal expression signature comprises at least one, two, three, four, five,

six, eight, 10, 15, 20, 25 or more of target sequences shown to have a correlation with no n

recurrent or recurrent prostate cancer, for example those depicted in SEQ ID NOs: 1-21 14 or a

subset thereof.

In some embodiments, the Prostate Cancer Prognostic Set comprises target sequences for

detecting expression products of SEQ IDs: 1-21 14. In some embodiments, the Prostate Cancer

Prognostic Set comprises probes for detecting expression levels of sequences exhibiting positive

and negative correlation with a disease status of interest are employed. For example, a

combination target sequences useful in these methods were found to include those encoding

RNAs corresponding to SEQ ID NOs: 1-913 (found at increased expression in prostate cancer

samples from NED patients) and/or corresponding to SEQ ID NOs: 914-21 14 (found at

increased expression levels in prostate cancer samples from SYS patients), where intermediate

levels of certain target sequences (Table 7) are observed in prostate cancer samples from PSA

patients with biochemical recurrence, where the RNA expression levels are indicative of a

disease state or outcome. Subgroups of these target sequences, as well as individual target

sequences, have been found useful in such methods.

In some embodiments, an RNA signature corresponding to SEQ ID NOs: 1, 4, 6, 9, 14-16, 18-21

915-917, 920, 922, 928, 929, 93 1, 935 and 936 (the 2 1-RNA' signature) and/or SEQ ID NOs: 1-

11, 914-920 (the ' 18-RNA' signature) and/or SEQ ID NOs: 1-4, 914,915) (the '6-RNA'

signature) and/or SEQ ID NOs: 1, 4, 6, 9, 14-16, 18-21, 915-917, 920, 922, 928, 929, 931, 935

and 936 (the '20-RNA' signature) and/or SEQ ID NOs 3, 36, 60, 63, 926, 971, 978, 999, 1014

and 1022 (the ' K)-RNA' signature) and/or SEQ ID NOs 1-3, 32, 33, 36, 46, 60, 63, 66, 69, 88,

100, 241, 265, 334, 437, 920, 925, 934, 945, 947, 954, 971, 978, 999, 1004, 1014, 1022, 1023,

1032, 1080, 1093, 1101, 1164, 1248, 1304, 131 1, 1330, 1402 and 1425 (the '41 -RNA' signature)

are formulated into a linear combination of their respective expression values for each patient

generating a patient outcome predictor ('POP') score and indicative of the disease status of the

patient after prostatectomy.

Exemplary subsets and combinations of interest also include at least five, six, 10, 15, 18, 20, 23,

25, 27, 30, 35, 40, 45, 50, 55, 60, 70, 80, 90, 100, 125, 150, 175, 200, 225, 250, 275, 300, 350,

400, 450, 500, 750, 1000, 1200, 1400, 1600, 1800, 2000, or all 2 114 target sequences in Table 4;

at least five, six, 10, 15, 18, 20, 23, 25, 27, 30, 35, 40, 45, 50, 55, 60, 70, 80, 90, 100, 125, 150,

175, 200, 225, 250, 275, 300, 350, 400, 450, 500, or all 526 target sequences in Table 7 ; SEQ ID

NOs: l , 4, 915, 6, 916, 9, 917, 920, 922, 14, 15, 16, 928, 929, 18, 19, 931, 20, 21, 935, 936, or

combinations thereof; SEQ ID NOs: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 914, 915, 916, 917, 918, 919,

920, or combinations thereof; SEQ ID NOs: 1, 4, 6, 9, 14-16, 18-21, 915-917, 920, 922, 928,

929, 93 1, 935, 936 or combinations thereof; SEQ ID NOs 3, 36, 60, 63, 926, 971, 978, 999,

1014, 1022 or combinations thereof; SEQ ID NOs 1-3, 32, 33, 36, 46, 60, 63, 66, 69, 88, 100,

241, 265, 334, 437, 920, 925, 934, 945, 947, 954, 971, 978, 999, 1004, 1014, 1022, 1023, 1032,

1080, 1093, 1101, 1164, 1248, 1304, 131 1, 1330, 1402, 1425 or combinations thereof; at least

one, two, three, four, five or six of SEQ ID NOs: l , 4, 6, 9, 14, 15, 16, 18, 19, 20, and 2 1 and at

least one, two, three, four, five or six of SEQ ID NOs:915, 916, 917, 920, 922, 928, 929, 931,

935, and 936; and at least one, two, three, four, five or six of SEQ ID NOs: 1, 2, 3, 4, 5, 6, 7, 8, 9,

10, and 11 at least one, two, three, four, five or six of at least one, two, three, four, five or six of

SEQ ID NOs:914, 915, 916, 917, 918, 919, and 920 and at least one, two, three, four, five or six

of SEQ ID NOs: 1, 4, 6, 9, 14-16, 18-21, 915-917, 920, 922, 928, 929, 93 1, 935, 936; and at least

one, two, three, four, five or six of SEQ ID NOs 3, 36, 60, 63, 926, 971, 978, 999, 1014, 1022;

and at least one, two, three, four, five or six of SEQ ID NOs 1-3, 32, 33, 36, 46, 60, 63, 66, 69,

88, 100, 241, 265, 334, 437, 920, 925, 934, 945, 947, 954, 971, 978, 999, 1004, 1014, 1022,

1023, 1032, 1080, 1093, 1101, 1164, 1248, 1304, 13 11, 1330, 1402, 1425.

Exemplary subsets of interest include those described herein, including in the examples.

Exemplary combinations of interest include those utilizing one or more of the sequences listed in

Tables 5, 7, 8, 9 or 10. Of particular interest are those combinations utilizing at least one

sequence exhibiting positive correlation with the trait of interest, as well as those combinations

utilizing at least one sequence exhibiting negative correlation with the trait of interest. Also of

interest are those combinations utilizing at least two, at least three, at least four, at least five or at

least six of those sequences exhibiting such a positive correlation, in combination with at least

two, at least three, at least four, at least five, or at least six of those sequences exhibiting such a

negative correlation. Exemplary combinations include those utilizing at least one, two, three,

four, five or six of the target sequences depicted in Tables 5 and 6 .

In some embodiments, increased relative expression of one or more of SEQ IDs: 1-913,

decreased relative expression of one or more of SEQ ID NOs:9 14-21 14 or a combination of any

thereof is indicative/predictive of the patient exhibiting no evidence of disease for at least seven

years or more after surgery. In some embodiments, increased relative expression of SEQ

IDs:9 14-21 14, decreased relative expression of one or more of SEQ ID NOs: 1-9 13 or a

combination of any thereof is indicative/predictive of the patient exhibiting systemic prostate

cancer. Increased or decreased expression of target sequences represented in these sequence

listings, or of the target sequences described in the examples, may be utilized in the methods of

the invention.

The Prostate Cancer Prognostic Set can optionally include one or more target sequences

specifically derived from the transcripts of one or more housekeeping genes and/or one or more

internal control target sequences and/or one or more negative control target sequences. In one

embodiment, these target sequences can, for example, be used to normalize expression data.

Housekeeping genes from which target sequences for inclusion in a Prostate Cancer Prognostic

Set can be derived from are known in the art and include those genes in which are expressed at a

constant level in normal and prostate cancer tissue.

The target sequences described herein may be used alone or in combination with each other or

with other known or later identified disease markers.

PROSTATE CANCER PROGNOSTIC PROBES / PRIMERS

The system of the present invention provides for combinations of polynucleotide probes that are

capable of detecting the target sequences of the Prostate Cancer Prognostic Sets. Individual

polynucleotide probes comprise a nucleotide sequence derived from the nucleotide sequence of

the target sequences or complementary sequences thereof. The nucleotide sequence of the

polynucleotide probe is designed such that it corresponds to, or is complementary to the target

sequences. The polynucleotide probe can specifically hybridize under either stringent or lowered

stringency hybridization conditions to a region of the target sequences, to the complement

thereof, or to a nucleic acid sequence (such as a cDNA) derived therefrom.

The selection of the polynucleotide probe sequences and determination of their uniqueness may

be carried out in silico using techniques known in the art, for example, based on a BLASTN

search of the polynucleotide sequence in question against gene sequence databases, such as the

Human Genome Sequence, UniGene, dbEST or the non-redundant database at NCBI. In one

embodiment of the invention, the polynucleotide probe is complementary to a region of a target

mRNA derived from a target sequence in the Prostate Cancer Prognostic Set. Computer

programs can also be employed to select probe sequences that will not cross hybridize or will not

hybridize non-specifically.

One skilled in the art will understand that the nucleotide sequence of the polynucleotide probe

need not be identical to its target sequence in order to specifically hybridize thereto. The

polynucleotide probes of the present invention, therefore, comprise a nucleotide sequence that is

at least about 75% identical to a region of the target gene or mRNA. In another embodiment, the

nucleotide sequence of the polynucleotide probe is at least about 90% identical a region of the

target gene or mRNA. In a further embodiment, the nucleotide sequence of the polynucleotide

probe is at least about 95% identical to a region of the target gene or mRNA. Methods of

determining sequence identity are known in the art and can be determined, for example, by using

the BLASTN program of the University of Wisconsin Computer Group (GCG) software or

provided on the NCBI website. The nucleotide sequence of the polynucleotide probes of the

present invention may exhibit variability by differing (e.g. by nucleotide substitution, including

transition or transversion) at one, two, three, four or more nucleotides from the sequence of the

target gene.

Other criteria known in the art may be employed in the design of the polynucleotide probes of

the present invention. For example, the probes can be designed to have <50% G content and/or

between about 25% and about 70% G+C content. Strategies to optimize probe hybridization to

the target nucleic acid sequence can also be included in the process of probe selection.

Hybridization under particular pH, salt, and temperature conditions can be optimized by taking

into account melting temperatures and by using empirical rules that correlate with desired

hybridization behaviours. Computer models may be used for predicting the intensity and

concentration-dependence of probe hybridization.

As is known in the art, in order to represent a unique sequence in the human genome, a probe

should be at least 15 nucleotides in length. Accordingly, the polynucleotide probes of the present

invention range in length from about 15 nucleotides to the full length of the target sequence or

target mRNA. In one embodiment of the invention, the polynucleotide probes are at least about

15 nucleotides in length. In another embodiment, the polynucleotide probes are at least about 20

nucleotides in length. In a further embodiment, the polynucleotide probes are at least about 25

nucleotides in length. In another embodiment, the polynucleotide probes are between about 15

nucleotides and about 500 nucleotides in length. In other embodiments, the polynucleotide

probes are between about 15 nucleotides and about 450 nucleotides, about 15 nucleotides and

about 400 nucleotides, about 15 nucleotides and about 350 nucleotides, about 15 nucleotides and

about 300 nucleotides in length.

The polynucleotide probes of a Prostate Cancer Prognostic Set can comprise RNA, DNA, RNA

or DNA mimetics, or combinations thereof, and can be single-stranded or double- stranded. Thus

the polynucleotide probes can be composed of naturally-occurring nucleobases, sugars and

covalent internucleoside (backbone) linkages as well as polynucleotide probes having non-

naturally-occurring portions which function similarly. Such modified or substituted

polynucleotide probes may provide desirable properties such as, for example, enhanced affinity

for a target gene and increased stability.

The system of the present invention further provides for primers and primer pairs capable of

amplifying target sequences defined by the Prostate Cancer Prognostic Set, or fragments or

subsequences or complements thereof. The nucleotide sequences of the Prostate Cancer

Prognostic set may be provided in computer-readable media for in silico applications and as a

basis for the design of appropriate primers for amplification of one or more target sequences of

the Prostate Cancer Prognostic Set.

Primers based on the nucleotide sequences of target sequences can be designed for use in

amplification of the target sequences. For use in amplification reactions such as PCR, a pair of

primers will be used. The exact composition of the primer sequences is not critical to the

invention, but for most applications the primers will hybridize to specific sequences of the

Prostate Cancer Prognostic Set under stringent conditions, particularly under conditions of high

stringency, as known in the art. The pairs of primers are usually chosen so as to generate an

amplification product of at least about 50 nucleotides, more usually at least about 100

nucleotides. Algorithms for the selection of primer sequences are generally known, and are

available in commercial software packages. These primers may be used in standard quantitative

or qualitative PCR-based assays to assess transcript expression levels of RNAs defined by the

Prostate Cancer Prognostic Set. Alternatively, these primers may be used in combination with

probes, such as molecular beacons in amplifications using real-time PCR.

In one embodiment, the primers or primer pairs, when used in an amplification reaction,

specifically amplify at least a portion of a nucleic acid depicted in one of SEQ ID NOs: 1-21 14

(or subgroups thereof as set forth herein), an RNA form thereof, or a complement to either

thereof.

As is known in the art, a nucleoside is a base-sugar combination and a nucleotide is a nucleoside

that further includes a phosphate group covalently linked to the sugar portion of the nucleoside.

In forming oligonucleotides, the phosphate groups covalently link adjacent nucleosides to one

another to form a linear polymeric compound, with the normal linkage or backbone of RNA and

DNA being a 3' to 5' phosphodiester linkage. Specific examples of polynucleotide probes or

primers useful in this invention include oligonucleotides containing modified backbones or non-

natural internucleoside linkages. As defined in this specification, oligonucleotides having

modified backbones include both those that retain a phosphorus atom in the backbone and those

that lack a phosphorus atom in the backbone. For the purposes of the present invention, and as

sometimes referenced in the art, modified oligonucleotides that do not have a phosphorus atom

in their internucleoside backbone can also be considered to be oligonucleotides.

Exemplary polynucleotide probes or primers having modified oligonucleotide backbones

include, for example, those with one or more modified internucleotide linkages that are

phosphorothioates, chiral phosphorothioates, phosphorodithioates, phosphotriesters,

aminoalkylphosphotriesters, methyl and other alkyl phosphonates including 3'-alkylene

phosphonates and chiral phosphonates, phosphinates, phosphoramidates including 3'amino

phosphoramidate and aminoalkylphosphoramidates, thionophosphoramidates, thionoalkyl-

phosphonates, thionoalkylphosphotriesters, and boranophosphates having normal 3'-5' linkages,

2'-5' linked analogs of these, and those having inverted polarity wherein the adjacent pairs of

nucleoside units are linked 3'-5' to 5'-3' or 2'-5' to 5'-2'. Various salts, mixed salts and free acid

forms are also included.

Exemplary modified oligonucleotide backbones that do not include a phosphorus atom are

formed by short chain alkyl or cycloalkyl internucleoside linkages, mixed heteroatom and alkyl

or cycloalkyl internucleoside linkages, or one or more short chain heteroatomic or heterocyclic

internucleoside linkages. Such backbones include morpholino linkages (formed in part from the

sugar portion of a nucleoside); siloxane backbones; sulfide, sulfoxide and sulphone backbones;

formacetyl and thioformacetyl backbones; methylene formacetyl and thioformacetyl backbones;

alkene containing backbones; sulphamate backbones; methyleneimino and methylenehydrazino

backbones; sulphonate and sulfonamide backbones; amide backbones; and others having mixed

N, O, S and CH2 component parts.

The present invention also contemplates oligonucleotide mimetics in which both the sugar and

the internucleoside linkage of the nucleotide units are replaced with novel groups. The base units

are maintained for hybridization with an appropriate nucleic acid target compound. An example

of such an oligonucleotide mimetic, which has been shown to have excellent hybridization

properties, is a peptide nucleic acid (PNA) [Nielsen et ah, Science, 254: 1497-1500 (1991)1. In

PNA compounds, the sugar-backbone of an oligonucleotide is replaced with an amide containing

backbone, in particular an aminoethylglycine backbone. The nucleobases are retained and are

bound directly or indirectly to aza-nitrogen atoms of the amide portion of the backbone.

The present invention also contemplates polynucleotide probes or primers comprising "locked

nucleic acids" (LNAs), which are novel conformationally restricted oligonucleotide analogues

containing a methylene bridge that connects the 2'-0 of ribose with the 4'-C (see, Singh et al,

Chem. Commun., 1998, 4:455-456). LNA and LNA analogues display very high duplex thermal

stabilities with complementary DNA and RNA, stability towards 3'-exonuclease degradation,

and good solubility properties. Synthesis of the LNA analogues of adenine, cytosine, guanine, 5-

methylcytosine, thymine and uracil, their oligomerization, and nucleic acid recognition

properties have been described (see Koshkin et al., Tetrahedron, 1998, 54:3607-3630). Studies

of mis-matched sequences show that LNA obey the Watson-Crick base pairing rules with

generally improved selectivity compared to the corresponding unmodified reference strands.

LNAs form duplexes with complementary DNA or RNA or with complementary LNA, with high

thermal affinities. The universality of LNA-mediated hybridization has been emphasized by the

formation of exceedingly stable LNA:LNA duplexes (Koshkin et al, J. Am. Chem. Soc, 1998,

120: 13252-13253). LNA:LNA hybridization was shown to be the most thermally stable nucleic

acid type duplex system, and the RNA-mimicking character of LNA was established at the

duplex level. Introduction of three LNA monomers (T or A) resulted in significantly increased

melting points toward DNA complements.

Synthesis of 2'-amino-LNA (Singh et al., J . Org. Chem., 1998, 63, 10035-10039) and T -

methylamino-LNA has been described and thermal stability of their duplexes with

complementary RNA and DNA strands reported. Preparation of phosphorothioate-LNA and T -

thio-LNA have also been described (Kumar et al, Bioorg. Med. Chem. Lett., 1998, 8:2219-

2222).

Modified polynucleotide probes or primers may also contain one or more substituted sugar

moieties. For example, oligonucleotides may comprise sugars with one of the following

substituents at the 2' position: OH; F; O-, S-, or N-alkyl; O-, S-, or N-alkenyl; O-, S- or N-

alkynyl; or O-alkyl-0-alkyl, wherein the alkyl, alkenyl and alkynyl may be substituted or

unsubstituted C i to C i0 alkyl or C2 to C i0 alkenyl and alkynyl. Examples of such groups are:

O[(CH 2)n 0 I111

CH , 0(CH 2)n OCH , 0(CH 2)n NH2, 0(CH 2)n CH , 0(CH 2)n ONH2, and 0(CH 2)n

ONf(CH 2)n CH ) 2, where n and m are from 1 to about 10. Alternatively, the oligonucleotides

may comprise one of the following substituents at the 2' position: C i to C i0 lower alkyl,

substituted lower alkyl, alkaryl, aralkyl, O-alkaryl or O-aralkyl, SH, SCH 1, OCN, Cl, Br, CN,

CF1, OCF 1, SOCH 1, SO2 CH1, ONO2, NO2, N1, NH2, heterocycloalkyl, heterocycloalkaryl,

aminoalkylamino, polyalkylamino, substituted silyl, an RNA cleaving group, a reporter group, an

intercalator, a group for improving the pharmacokinetic properties of an oligonucleotide, or a

group for improving the pharmacodynamic properties of an oligonucleotide, and other

substituents having similar properties. Specific examples include 2'-methoxyethoxy (2'-0-CH 2

CH2 OCH 1, also known as 2'-O-(2-methoxyethyl) or 2'-MOE) [Martin et al, HeIv. Chim. Acta,

78:486-504(1995)1, 2'-dimethylaminooxyethoxy (O(CH 2)2 ON(CH 1 2 group, also known as T -

DMAOE), 2'-methoxy (2'-0-CH 1), 2'-aminopropoxy (2'-OCH 2 CH2 CH2 NH2) and 2'-fluoro (T-

F).

Similar modifications may also be made at other positions on the polynucleotide probes or

primers, particularly the 3' position of the sugar on the 3' terminal nucleotide or in 2'-5' linked

oligonucleotides and the 5' position of 5' terminal nucleotide. Polynucleotide probes or primers

may also have sugar mimetics such as cyclobutyl moieties in place of the pentofuranosyl sugar.

Polynucleotide probes or primers may also include modifications or substitutions to the

nucleobase. As used herein, "unmodified" or "natural" nucleobases include the purine bases

adenine (A) and guanine (G), and the pyrimidine bases thymine (T), cytosine (C) and uracil (U).

Modified nucleobases include other synthetic and natural nucleobases such as 5-methylcytosine

(5-me-C), 5- hydroxymethyl cytosine, xanthine, hypoxanthine, 2-aminoadenine, 6-methyl and

other alkyl derivatives of adenine and guanine, 2-propyl and other alkyl derivatives of adenine

and guanine, 2-thiouracil, 2-thiothymine and 2-thiocytosine, 5-halouracil and cytosine, 5-

propynyl uracil and cytosine, 6-azo uracil, cytosine and thymine, 5-uracil (pseudouracil), 4-

thiouracil, 8-halo, 8-amino, 8-thiol, 8-thioalkyl, 8-hydroxyl and other 8-substituted adenines and

guanines, 5-halo particularly 5-bromo, 5-trifluoromethyl and other 5-substituted uracils and

cytosines, 7-methylguanine and 7-methyladenine, 8-azaguanine and 8-azaadenine, 7-

deazaguanine and 7-deazaadenine and 3-deazaguanine and 3-deazaadenine. Further nucleobases

include those disclosed in U.S. Pat. No. 3,687,808; The Concise Encyclopedia Of Polymer

Science And Engineering, (1990) pp 858-859, Kroschwitz, J . L, ed. John Wiley & Sons;

Englisch et ah, Angewandte Chemie, Int. Ed., 30:613 (1991); and Sanghvi, Y. S., (1993)

Antisense Research and Applications, pp 289-302, Crooke, S . T. and Lebleu, B., ed., CRC Press.

Certain of these nucleobases are particularly useful for increasing the binding affinity of the

polynucleotide probes of the invention. These include 5-substituted pyrimidines, 6-

azapyrimidines and N-2, N-6 and O-6 substituted purines, including 2-aminopropyladenine, 5-

propynyluracil and 5-propynylcytosine. 5-methylcytosine substitutions have been shown to

increase nucleic acid duplex stability by 0.6-1 .20C [Sanghvi, Y. S., (1993) Antisense Research

and Applications, pp 276-278, Crooke, S . T. and Lebleu, B., ed., CRC Press, Boca Raton].

One skilled in the art will recognize that it is not necessary for all positions in a given

polynucleotide probe or primer to be uniformly modified. The present invention, therefore,

contemplates the incorporation of more than one of the aforementioned modifications into a

single polynucleotide probe or even at a single nucleoside within the probe or primer.

One skilled in the art will also appreciate that the nucleotide sequence of the entire length of the

polynucleotide probe or primer does not need to be derived from the target sequence. Thus, for

example, the polynucleotide probe may comprise nucleotide sequences at the 5' and/or 3' termini

that are not derived from the target sequences. Nucleotide sequences which are not derived from

the nucleotide sequence of the target sequence may provide additional functionality to the

polynucleotide probe. For example, they may provide a restriction enzyme recognition sequence

or a "tag" that facilitates detection, isolation, purification or immobilisation onto a solid support.

Alternatively, the additional nucleotides may provide a self-complementary sequence that allows

the primer/probe to adopt a hairpin configuration. Such configurations are necessary for certain

probes, for example, molecular beacon and Scorpion probes, which can be used in solution

hybridization techniques.

The polynucleotide probes or primers can incorporate moieties useful in detection, isolation,

purification, or immobilisation, if desired. Such moieties are well-known in the art (see, for

example, Ausubel et ah, (1997 & updates) Current Protocols in Molecular Biology, Wiley &

Sons, New York) and are chosen such that the ability of the probe to hybridize with its target

sequence is not affected.

Examples of suitable moieties are detectable labels, such as radioisotopes, fluorophores,

chemiluminophores, enzymes, colloidal particles, and fluorescent microparticles, as well as

antigens, antibodies, haptens, avidin/streptavidin, biotin, haptens, enzyme cofactors / substrates,

enzymes, and the like.

A label can optionally be attached to or incorporated into a probe or primer polynucleotide to

allow detection and/or quantitation of a target polynucleotide representing the target sequence of

interest. The target polynucleotide may be the expressed target sequence RNA itself, a cDNA

copy thereof, or an amplification product derived therefrom, and may be the positive or negative

strand, so long as it can be specifically detected in the assay being used. Similarly, an antibody

may be labeled.

In certain multiplex formats, labels used for detecting different targets may be distinguishable.

The label can be attached directly (e.g., via covalent linkage) or indirectly, e.g., via a bridging

molecule or series of molecules (e.g., a molecule or complex that can bind to an assay

component, or via members of a binding pair that can be incorporated into assay components,

e.g. biotin-avidin or streptavidin). Many labels are commercially available in activated forms

which can readily be used for such conjugation (for example through amine acylation), or labels

may be attached through known or determinable conjugation schemes, many of which are known

in the art.

Labels useful in the invention described herein include any substance which can be detected

when bound to or incorporated into the biomolecule of interest. Any effective detection method

can be used, including optical, spectroscopic, electrical, piezoelectrical, magnetic, Raman

scattering, surface plasmon resonance, colorimetric, calorimetric, etc. A label is typically

selected from a chromophore, a lumiphore, a fluorophore, one member of a quenching system, a

chromogen, a hapten, an antigen, a magnetic particle, a material exhibiting nonlinear optics, a

semiconductor nanocrystal, a metal nanopaiticle, an enzyme, an antibody or binding portion or

equivalent thereof, an aptamer, and one member of a binding pair, and combinations thereof.

Quenching schemes may be used, wherein a quencher and a fluorophore as members of a

quenching pair may be used on a probe, such that a change in optical parameters occurs upon

binding to the target introduce or quench the signal from the fluorophore. One example of such a

system is a molecular beacon. Suitable quencher/fluorophore systems are known in the art. The

label may be bound through a variety of intermediate linkages. For example, a polynucleotide

may comprise a biotin-binding species, and an optically detectable label may be conjugated to

biotin and then bound to the labeled polynucleotide. Similarly, a polynucleotide sensor may

comprise an immunological species such as an antibody or fragment, and a secondary antibody

containing an optically detectable label may be added.

Chromophores useful in the methods described herein include any substance which can absorb

energy and emit light. For multiplexed assays, a plurality of different signaling chromophores

can be used with detectably different emission spectra. The chromophore can be a lumophore or

a fluorophore. Typical fluorophores include fluorescent dyes, semiconductor nanocrystals,

lanthanide chelates, polynucleotide-specific dyes and green fluorescent protein.

Coding schemes may optionally be used, comprising encoded particles and/or encoded tags

associated with different polynucleotides of the invention. A variety of different coding schemes

are known in the art, including fluorophores, including SCNCs, deposited metals, and RF tags.

Polynucleotides from the described target sequences may be employed as probes for detecting

target sequences expression, for ligation amplification schemes, or may be used as primers for

amplification schemes of all or a portion of a target sequences. When amplified, either strand

produced by amplification may be provided in purified and/or isolated form.

In one embodiment, polynucleotides of the invention include a nucleic acid depicted in(a) any

one of SEQ ID NOs: 1-21 14, or a subgroup thereof as set forth herein; (b) an RNA form of any

one of the nucleic acids depicted in SEQ ID NOs: 1-21 14, or a subgroup thereof as set forth

herein; (c) a peptide nucleic acid form of any of the nucleic acids depicted in SEQ ID NOs: 1-

2 114, or a subgroup thereof as set forth herein; (d) a nucleic acid comprising at least 20

consecutive bases of any of (a-c); (e) a nucleic acid comprising at least 25 bases having at least

90% sequenced identity to any of (a-c); and (f) a complement to any of (a-e).

Complements may take any polymeric form capable of base pairing to the species recited in (a)-

(e), including nucleic acid such as RNA or DNA, or may be a neutral polymer such as a peptide

nucleic acid. Polynucleotides of the invention can be selected from the subsets of the recited

nucleic acids described herein, as well as their complements.

In some embodiments, polynucleotides of the invention comprise at least 20 consecutive bases as

depicted in SEQ ID NOs: 1-21 14, or a complement thereto. The polynucleotides may comprise

at least 21, 22, 23, 24, 25, 27, 30, 32, 35 or more consecutive bases as depicted in SEQ ID

NOs: 1-21 14, as applicable.

In some embodiments, the nucleic acid in (a) can be selected from those in Table 3, and from

SEQ ID NOs: l , 4 , 915, 6, 916, 9, 917, 920, 922, 14, 15, 16, 928, 929, 18, 19, 931, 20, 21, 935,

and 936; or from SEQ ID NOs: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 914, 915, 916, 917, 918, 919, and

920; or from SEQ ID NOs: 1, 4, 6, 9, 14-16, 18-21, 915-917, 920, 922, 928, 929, 931, 935 and

936; or from SEQ ID NOs 3, 36, 60, 63, 926, 971, 978, 999, 1014 and 1022; or from SEQ ID

NOs 1-3, 32, 33, 36, 46, 60, 63, 66, 69, 88, 100, 241, 265, 334, 437, 920, 925, 934, 945, 947,

954, 971, 978, 999, 1004, 1014, 1022, 1023, 1032, 1080, 1093, 1101, 1164, 1248, 1304, 13 11,

1330, 1402 and 1425.

The polynucleotides may be provided in a variety of formats, including as solids, in solution, or

in an array. The polynucleotides may optionally comprise one or more labels, which may be

chemically and/or enzymatically incorporated into the polynucleotide.

In one embodiment, solutions comprising polynucleotide and a solvent are also provided. In

some embodiments, the solvent may be water or may be predominantly aqueous. In some

embodiments, the solution may comprise at least two, three, four, five, six, seven, eight, nine,

ten, twelve, fifteen, seventeen, twenty or more different polynucleotides, including primers and

primer pairs, of the invention. Additional substances may be included in the solution, alone or in

combination, including one or more labels, additional solvents, buffers, biomolecules,

polynucleotides, and one or more enzymes useful for performing methods described herein,

including polymerases and ligases. The solution may further comprise a primer or primer pair

capable of amplifying a polynucleotide of the invention present in the solution.

In some embodiments, one or more polynucleotides provided herein can be provided on a

substrate. The substrate can comprise a wide range of material, either biological, nonbiological,

organic, inorganic, or a combination of any of these. For example, the substrate may be a

polymerized Langmuir Blodgett film, functionalized glass, Si, Ge, GaAs, GaP, SiCh, SiN4,

modified silicon, or any one of a wide variety of gels or polymers such as

(poly)tetrafluoroethylene, (poly)vinylidenedifluoride, polystyrene, cross-linked polystyrene,

polyacrylic, polylactic acid, polyglycolic acid, poly(lactide coglycolide), polyanhydrides,

poly(methyl methacrylate), poly(ethylene-co-vinyl acetate), polysiloxanes, polymeric silica,

latexes, dextran polymers, epoxies, polycarbonates, or combinations thereof. Conducting

polymers and photoconductive materials can be used.

Substrates can be planar crystalline substrates such as silica based substrates (e.g. glass, quartz,

or the like), or crystalline substrates used in, e.g., the semiconductor and microprocessor

industries, such as silicon, gallium arsenide, indium doped GaN and the like, and includes

semiconductor nanocrystals.

The substrate can take the form of an array, a photodiode, an optoelectronic sensor such as an

optoelectronic semiconductor chip or optoelectronic thin-film semiconductor, or a biochip. The

location(s) of probe(s) on the substrate can be addressable; this can be done in highly dense

formats, and the location(s) can be microaddressable or nanoaddressable.

Silica aerogels can also be used as substrates, and can be prepared by methods known in the art.

Aerogel substrates may be used as free standing substrates or as a surface coating for another

substrate material.

The substrate can take any form and typically is a plate, slide, bead, pellet, disk, particle,

microparticle, nanoparticle, strand, precipitate, optionally porous gel, sheets, tube, sphere,

container, capillary, pad, slice, film, chip, multiwell plate or dish, optical fiber, etc. The

substrate can be any form that is rigid or semi-rigid. The substrate may contain raised or

depressed regions on which an assay component is located. The surface of the substrate can be

etched using known techniques to provide for desired surface features, for example trenches, v-

grooves, mesa structures, or the like.

Surfaces on the substrate can be composed of the same material as the substrate or can be made

from a different material, and can be coupled to the substrate by chemical or physical means.

Such coupled surfaces may be composed of any of a wide variety of materials, for example,

polymers, plastics, resins, polysaccharides, silica or silica-based materials, carbon, metals,

inorganic glasses, membranes, or any of the above-listed substrate materials. The surface can be

optically transparent and can have surface Si-OH functionalities, such as those found on silica

surfaces.

The substrate and/or its optional surface can be chosen to provide appropriate characteristics for

the synthetic and/or detection methods used. The substrate and/or surface can be transparent to

allow the exposure of the substrate by light applied from multiple directions. The substrate

and/or surface may be provided with reflective "mirror" structures to increase the recovery of

light.

The substrate and/or its surface is generally resistant to, or is treated to resist, the conditions to

which it is to be exposed in use, and can be optionally treated to remove any resistant material

after exposure to such conditions.

The substrate or a region thereof may be encoded so that the identity of the sensor located in the

substrate or region being queried may be determined. Any suitable coding scheme can be used,

for example optical codes, RFID tags, magnetic codes, physical codes, fluorescent codes, and

combinations of codes.

PREPARATION OF PROBES AND PRIMERS

The polynucleotide probes or primers of the present invention can be prepared by conventional

techniques well-known to those skilled in the art. For example, the polynucleotide probes can be

prepared using solid-phase synthesis using commercially available equipment. As is well-known

in the art, modified oligonucleotides can also be readily prepared by similar methods. The

polynucleotide probes can also be synthesized directly on a solid support according to methods

standard in the art. This method of synthesizing polynucleotides is particularly useful when the

polynucleotide probes are part of a nucleic acid array.

Polynucleotide probes or primers can be fabricated on or attached to the substrate by any suitable

method, for example the methods described in U.S. Pat. No. 5,143,854, PCT Publ. No. WO

92/10092, U.S. Patent Application Ser. No. 07/624,120, filed Dec. 6, 1990 (now abandoned),

Fodor et al., Science, 25 1: 767-777 (1991), and PCT Publ. No. WO 90/15070). Techniques for

the synthesis of these arrays using mechanical synthesis strategies are described in, e.g., PCT

Publication No. WO 93/09668 and U.S. Pat. No. 5,384,261. Still further techniques include bead

based techniques such as those described in PCT Appl. No. PCT/US93/04145 and pin based

methods such as those described in U.S. Pat. No. 5,288,5 14. Additional flow channel or spotting

methods applicable to attachment of sensor polynucleotides to a substrate are described in U . S .

Patent Application Ser. No. 07/980,523, filed Nov. 20, 1992, and U.S. Pat. No. 5,384,26 1.

Alternatively, the polynucleotide probes of the present invention can be prepared by enzymatic

digestion of the naturally occurring target gene, or mRNA or cDNA derived therefrom, by

methods known in the art.

PROSTATECANCER PROGNOSTIC METHODS

The present invention further provides methods for characterizing prostate cancer sample for

recurrence risk. The methods use the Prostate Cancer Prognostic Sets, probes and primers

described herein to provide expression signatures or profiles from a test sample derived from a

subject having or suspected of having prostate cancer. In some embodiments, such methods

involve contacting a test sample with Prostate Cancer Prognostic probes (either in solution or

immobilized) under conditions that permit hybridization of the probe(s) to any target nucleic

acid(s) present in the test sample and then detecting any probe: target duplexes formed as an

indication of the presence of the target nucleic acid in the sample. Expression patterns thus

determined are then compared to one or more reference profiles or signatures. Optionally, the

expression pattern can be normalized. The methods use the Prostate Cancer Prognostic Sets,

probes and primers described herein to provide expression signatures or profiles from a test

sample derived from a subject to classify the prostate cancer as recurrent or non-recurrent.

In some embodiments, such methods involve the specific amplification of target sequences

nucleic acid(s) present in the test sample using methods known in the art to generate an

expression profile or signature which is then compared to a reference profile or signature.

In some embodiments, the invention further provides for prognosing patient outcome, predicting

likelihood of recurrence after prostatectomy and/or for designating treatment modalities.

In one embodiment, the methods generate expression profiles or signatures detailing the

expression of the 2 114 target sequences having altered relative expression with different prostate

cancer outcomes. In one embodiment, the methods generate expression profiles or signatures

detailing the expression of the subsets of these target sequences having 526 or 18 target

sequences as described in the examples.

In some embodiments, increased relative expression of one or more of SEQ IDs: 1-913,

decreased relative expression of one or more of SEQ ID NOs:9 14-21 14 or a combination of any

thereof is indicative of a non-recurrent form of prostate cancer and may be predictive a NED

clinical outcome after surgery. In some embodiments, increased relative expression of SEQ

IDs:9 14-21 14, decreased relative expression of one or more of SEQ ID NOs: 1-9 13 or a

combination of any thereof is indicative of a recurrent form of prostate cancer and may be

predictive of a SYS clinical outcome after surgery. Increased or decreased expression of target

sequences represented in these sequence listings, or of the target sequences described in the

examples, may be utilized in the methods of the invention.

In one embodiment, intermediate levels of expression of one or more target sequences depicted

in Table 7 indicate a probability of future biochemical recurrence.

In some embodiments, the methods detect combinations of expression levels of sequences

exhibiting positive and negative correlation with a disease status. In one embodiment, the

methods detect a minimal expression signature.

Any method of detecting and/or quantitating the expression of the encoded target sequences can

in principle be used in the invention. Such methods can include Northern blotting, array or

microarray hybridization, by enzymatic cleavage of specific structures (e.g., an Invader® assay,

Third Wave Technologies, e.g. as described in U.S. Pat. Nos. 5,846,717, 6,090,543; 6,001,567;

5,985,557; and 5,994,069) and amplification methods, e.g. RT-PCR, including in a TaqMan®

assay (PE Biosystems, Foster City, Calif., e.g. as described in U.S. Pat. Nos. 5,962,233 and

5,538,848), and may be quantitative or semi-quantitative, and may vary depending on the origin,

amount and condition of the available biological sample. Combinations of these methods may

also be used. For example, nucleic acids may be amplified, labeled and subjected to microarray

analysis. Single-molecule sequencing (e.g., Illumina, Helicos, PacBio, ABI SOLID), in situ

hybridization, bead-array technologies (e.g., Luminex xMAP, Illumina BeadChips), branched

DNA technology (e.g., Panomics, Genisphere).

The expressed target sequences can be directly detected and/or quantitated, or may be copied

and/or amplified to allow detection of amplified copies of the expressed target sequences or its

complement. In some embodiments, degraded and/or fragmented RNA can be usefully analyzed

for expression levels of target sequences, for example RNA having an RNA integrity number of

less than 8 .

In some embodiments, quantitative RT-PCR assays are used to measure the expression level of

target sequences depicted in SEQ IDs: 1-21 14. In other embodiments, a GeneChip or microarray

can be used to measure the expression of one or more of the target sequences.

Molecular assays measure the relative expression levels of the target sequences, which can be

normalized to the expression levels of one or more control sequences, for example array control

sequences and/or one or more housekeeping genes, for example GAPDH. Increased (or

decreased) relative expression of the target sequences as described herein, including any of SEQ

ID NOs: 1-21 14, may thus be used alone or in any combination with each other in the methods

described herein. In addition, negative control probes may be included.

DIAGNOSTIC SAMPLES

Diagnostic samples for use with the systems and in the methods of the present invention

comprise nucleic acids suitable for providing RNAs expression information. In principle, the

biological sample from which the expressed RNA is obtained and analyzed for target sequence

expression can be any material suspected of comprising prostate cancer tissue or cells. The

diagnostic sample can be a biological sample used directly in a method of the invention.

Alternatively, the diagnostic sample can be a sample prepared from a biological sample.

In one embodiments, the sample or portion of the sample comprising or suspected of comprising

prostate cancer tissue or cells can be any source of biological material, including cells, tissue or

fluid, including bodily fluids. Non-limiting examples of the source of the sample include an

aspirate, a needle biopsy, a cytology pellet, a bulk tissue preparation or a section thereof obtained

for example by surgery or autopsy, lymph fluid, blood, plasma, serum, tumors, and organs.

The samples may be archival samples, having a known and documented medical outcome, or

may be samples from current patients whose ultimate medical outcome is not yet known.

In some embodiments, the sample may be dissected prior to molecular analysis. The sample

may be prepared via macrodissection of a bulk tumor specimen or portion thereof, or may be

treated via microdissection, for example via Laser Capture Microdissection (LCM).

The sample may initially be provided in a variety of states, as fresh tissue, fresh frozen tissue,

fine needle aspirates, and may be fixed or unfixed. Frequently, medical laboratories routinely

prepare medical samples in a fixed state, which facilitates tissue storage. A variety of fixatives

can be used to fix tissue to stabilize the morphology of cells, and may be used alone or in

combination with other agents. Exemplary fixatives include crosslinking agents, alcohols,

acetone, Bouin's solution, Zenker solution, HeIy solution, osmic acid solution and Carnoy

solution.

Crosslinking fixatives can comprise any agent suitable for forming two or more covalent bonds,

for example an aldehyde. Sources of aldehydes typically used for fixation include formaldehyde,

paraformaldehyde, glutaraldehyde or formalin. Preferably, the crosslinking agent comprises

formaldehyde, which may be included in its native form or in the form of paraformaldehyde or

formalin. One of skill in the art would appreciate that for samples in which crosslinking

fixatives have been used special preparatory steps may be necessary including for example

heating steps and proteinase-k digestion; see methods

One or more alcohols may be used to fix tissue, alone or in combination with other fixatives.

Exemplary alcohols used for fixation include methanol, ethanol and isopropanol.

Formalin fixation is frequently used in medical laboratories. Formalin comprises both an

alcohol, typically methanol, and formaldehyde, both of which can act to fix a biological sample.

Whether fixed or unfixed, the biological sample may optionally be embedded in an embedding

medium. Exemplary embedding media used in histology including paraffin, Tissue-Tek®

V.I.P. IM, Paramat, Paramat Extra, Paraplast, Paraplast X-tra, Paraplast Plus, Peel Away Paraffin

Embedding Wax, Polyester Wax, Carbowax Polyethylene Glycol, Polyfin IM, Tissue Freezing

Medium TFM IM, Cryo-Gel IM, and OCT Compound (Electron Microscopy Sciences, Hatfield,

PA). Prior to molecular analysis, the embedding material may be removed via any suitable

techniques, as known in the art. For example, where the sample is embedded in wax, the

embedding material may be removed by extraction with organic solvent(s), for example xylenes.

Kits are commercially available for removing embedding media from tissues. Samples or

sections thereof may be subjected to further processing steps as needed, for example serial

hydration or dehydration steps.

In some embodiments, the sample is a fixed, wax-embedded biological sample. Frequently,

samples from medical laboratories are provided as fixed, wax-embedded samples, most

commonly as formalin-fixed, paraffin embedded (FFPE) tissues.

Whatever the source of the biological sample, the target polynucleotide that is ultimately assayed

can be prepared synthetically (in the case of control sequences), but typically is purified from the

biological source and subjected to one or more preparative steps. The RNA may be purified to

remove or diminish one or more undesired components from the biological sample or to

concentrate it. Conversely, where the RNA is too concentrated for the particular assay, it may be

diluted.

RNA EXTRACTION

RNA can be extracted and purified from biological samples using any suitable technique. A

number of techniques are known in the art, and several are commercially available (e.g.,

FormaPure 1M nucleic acid extraction kit, Agencouit Biosciences, Beverly MA, High Pure FFPE

RNA Micro Kit IM, Roche Applied Science, Indianapolis, IN). RNA can be extracted from

frozen tissue sections using TRIzol (Invitrogen, Carlsbad, CA) and purified using RNeasy

Protect kit (Qiagen, Valencia, CA). RNA can be further purified using DNAse I treatment

(Ambion, Austin, TX) to eliminate any contaminating DNA. RNA concentrations can be made

using a Nanodrop ND-K)OO spectrophotometer (Nanodrop Technologies, Rockland, DE). RNA

integrity can be evaluated by running electropherograms, and RNA integrity number (RIN, a

correlative measure that indicates intactness of mRNA) can be determined using the RNA 6000

PicoAssay for the Bioanalyzer 2100 (Agilent Technologies, Santa Clara, CA).

REVERSE TRANSCRIPTION FOR QRT-PCR ANALYSIS

Reverse transcription can be performed using the Omniscript kit (Qiagen, Valencia, CA),

Superscript III kit (Invitrogen, Carlsbad, CA), for RT-PCR. Target- specific priming can be

performed in order to increase the sensitivity of detection of target sequences and generate

target-specific cDNA.

TAQM ΛN® GENE EXPRESSION ANALYSIS

TaqMan ® RT-PCR can be performed using Applied Biosystems Prism (ABI) 7900 HT

instruments in a 5 µl volume with target sequence-specific cDNA equivalent to 1 ng total RNA.

Primers and probes concentrations for TaqMan analysis are added to amplify fluorescent

amplicons using PCR cycling conditions such as 950C for 10 minutes for one cycle, 950C for 20

seconds, and 6O0C for 45 seconds for 40 cycles. A reference sample can be assayed to ensure

reagent and process stability. Negative controls (i.e., no template) should be assayed to monitor

any exogenous nucleic acid contamination.

AMPLIFICATION AND HYBRIDIZATION

Following sample collection and nucleic acid extraction, the nucleic acid portion of the sample

comprising RNA that is or can be used to prepare the target polynucleotide(s) of interest can be

subjected to one or more preparative reactions. These preparative reactions can include in vitro

transcription (IVT), labeling, fragmentation, amplification and other reactions. mRNA can first

be treated with reverse transcriptase and a primer to create cDNA prior to detection, quantitation

and/or amplification; this can be done in vitro with purified mRNA or in situ, e.g., in cells or

tissues affixed to a slide.

By "amplification" is meant any process of producing at least one copy of a nucleic acid, in this

case an expressed RNA, and in many cases produces multiple copies. An amplification product

can be RNA or DNA, and may include a complementary strand to the expressed target sequence.

DNA amplification products can be produced initially through reverse translation and then

optionally from further amplification reactions. The amplification product may include all or a

portion of a target sequence, and may optionally be labeled. A variety of amplification methods

are suitable for use, including polymerase-based methods and ligation-based methods.

Exemplary amplification techniques include the polymerase chain reaction method (PCR), the

ligase chain reaction (LCR), ribozyme-based methods, self sustained sequence replication (3SR),

nucleic acid sequence-based amplification (NASBA), the use of Q Beta replicase, reverse

transcription, nick translation, and the like.

Asymmetric amplification reactions may be used to preferentially amplify one strand

representing the target sequence that is used for detection as the target polynucleotide. In some

cases, the presence and/or amount of the amplification product itself may be used to determine

the expression level of a given target sequence. In other instances, the amplification product

may be used to hybridize to an array or other substrate comprising sensor polynucleotides which

are used to detect and/or quantitate target sequence expression.

The first cycle of amplification in polymerase-based methods typically forms a primer extension

product complementary to the template strand. If the template is single-stranded RNA, a

polymerase with reverse transcriptase activity is used in the first amplification to reverse

transcribe the RNA to DNA, and additional amplification cycles can be performed to copy the

primer extension products. The primers for a PCR must, of course, be designed to hybridize to

regions in their corresponding template that will produce an amplifiable segment; thus, each

primer must hybridize so that its 3' nucleotide is paired to a nucleotide in its complementary

template strand that is located 3' from the 3' nucleotide of the primer used to replicate that

complementary template strand in the PCR.

The target polynucleotide can be amplified by contacting one or more strands of the target

polynucleotide with a primer and a polymerase having suitable activity to extend the primer and

copy the target polynucleotide to produce a full-length complementary polynucleotide or a

smaller portion thereof. Any enzyme having a polymerase activity that can copy the target

polynucleotide can be used, including DNA polymerases, RNA polymerases, reverse

transcriptases, enzymes having more than one type of polymerase or enzyme activity. The

enzyme can be thermolabile or thermostable. Mixtures of enzymes can also be used. Exemplary

enzymes include: DNA polymerases such as DNA Polymerase I ("Pol I"), the Klenow fragment

of Pol I, T4, T7, Sequenase® T7, Sequenase® Version 2.0 T7, Tub, Taq, Tth, Pfx, Pfii, Tsp, TfI,

TH and Pyrococcus sp GB-D DNA polymerases; RNA polymerases such as E . coll, SP6, T3

and T7 RNA polymerases; and reverse transcriptases such as AMV, M-MuLV, MMLV, RNAse

H MMLV (Superscript®), Superscript® II, ThermoScript®, HIV-I, and RAV2 reverse

transcriptases. All of these enzymes are commercially available. Exemplary polymerases with

multiple specificities include RAV2 and TH (exo-) polymerases. Exemplary thermostable

polymerases include Tub, Taq, Tth, Pfx, Pfu, Tsp, TfI, TH and Pyrococcus sp. GB-D DNA

polymerases.

Suitable reaction conditions are chosen to permit amplification of the target polynucleotide,

including pH, buffer, ionic strength, presence and concentration of one or more salts, presence

and concentration of reactants and cofactors such as nucleotides and magnesium and/or other

metal ions (e.g., manganese), optional cosolvents, temperature, thermal cycling profile for

amplification schemes comprising a polymerase chain reaction, and may depend in part on the

polymerase being used as well as the nature of the sample. Cosolvents include formamide

(typically at from about 2 to about 10 %), glycerol (typically at from about 5 to about 10 %), and

DMSO (typically at from about 0.9 to about 10 %). Techniques may be used in the amplification

scheme in order to minimize the production of false positives or artifacts produced during

amplification. These include "touchdown" PCR, hot-start techniques, use of nested primers, or

designing PCR primers so that they form stem-loop structures in the event of primer-dimer

formation and thus are not amplified. Techniques to accelerate PCR can be used, for example

centrifugal PCR, which allows for greater convection within the sample, and comprising infrared

heating steps for rapid heating and cooling of the sample. One or more cycles of amplification

can be performed. An excess of one primer can be used to produce an excess of one primer

extension product during PCR; preferably, the primer extension product produced in excess is

the amplification product to be detected. A plurality of different primers may be used to amplify

different target polynucleotides or different regions of a particular target polynucleotide within

the sample.

An amplification reaction can be performed under conditions which allow an optionally labeled

sensor polynucleotide to hybridize to the amplification product during at least part of an

amplification cycle. When the assay is performed in this manner, real-time detection of this

hybridization event can take place by monitoring for light emission or fluorescence during

amplification, as known in the art.

Where the amplification product is to be used for hybridization to an array or microarray, a

number of suitable commercially available amplification products are available. These include

amplification kits available from NuGEN, Inc. (San Carlos, CA), including the WT-Ovation IM

System, WT-Ovation IM System v2, WT-Ovation IM Pico System, WT-Ovation IM FFPE Exon

Module, WT-Ovation IM FFPE Exon Module RiboAmp and RiboAmp Plus RNA Amplification

Kits (MDS Analytical Technologies (formerly Arcturus) (Mountain View, CA), Genisphere, Inc.

(Hatfield, PA), including the RampUp Plus IM and SenseAmp IM RNA Amplification kits, alone

or in combination. Amplified nucleic acids may be subjected to one or more purification

reactions after amplification and labeling, for example using magnetic beads (e.g., RNAClean

magnetic beads, Agencourt Biosciences).

Multiple RNA biomarkers can be analyzed using real-time quantitative multiplex RT-PCR

platforms and other multiplexing technologies such as GenomeLab GeXP Genetic Analysis

System (Beckman Coulter, Foster City, CA), SmartCycler® 9600 or GeneXpert(R) Systems

(Cepheid, Sunnyvale, CA), ABI 7900 HT Fast Real Time PCR system (Applied Biosystems,

Foster City, CA), LightCycler® 480 System (Roche Molecular Systems, Pleasanton, CA),

xMAP 100 System (Luminex, Austin, TX) Solexa Genome Analysis System (Illumina,

Hayward, CA), OpenArray Real Time qPCR (BioTrove, Woburn, MA) and BeadXpress System

(Illumina, Hayward, CA).

PROSTATE CLASSIFICATION ARRAYS

The present invention contemplates that a Prostate Cancer Prognostic Set or probes derived

therefrom may be provided in an array format. In the context of the present invention, an "array"

is a spatially or logically organized collection of polynucleotide probes. Any array comprising

sensor probes specific for two or more of SEQ ID NOs: 1-21 14 or a product derived therefrom

can be used. Desirably, an array will be specific for 5, 10, 15, 20, 25, 30, 50, 75, 100, 150, 200,

250, 300, 350, 400, 450, 500, 600, 700, 1000, 1200, 1400, 1600, 1800, 2000 or more of SEQ ID

NOs: 1-21 14. Expression of these sequences may be detected alone or in combination with other

transcripts. In some embodiments, an array is used which comprises a wide range of sensor

probes for pro state- specific expression products, along with appropriate control sequences. An

array of interest is the Human Exon 1.0 ST Array (HuEx 1.0 ST, Affymetrix, Inc., Santa Clara,

CA.).

Typically the polynucleotide probes are attached to a solid substrate and are ordered so that the

location (on the substrate) and the identity of each are known. The polynucleotide probes can be

attached to one of a variety of solid substrates capable of withstanding the reagents and

conditions necessary for use of the array. Examples include, but are not limited to, polymers,

such as (poly)tetrafluoroethylene, (poly)vinylidenedifluoride, polystyrene, polycarbonate,

polypropylene and polystyrene; ceramic; silicon; silicon dioxide; modified silicon; (fused) silica,

quartz or glass; functionalized glass; paper, such as filter paper; diazotized cellulose;

nitrocellulose filter; nylon membrane; and polyacrylamide gel pad. Substrates that are

transparent to light are useful for arrays that will be used in an assay that involves optical

detection.

Examples of array formats include membrane or filter arrays (for example, nitrocellulose, nylon

arrays), plate arrays (for example, multiwell, such as a 24-, 96-, 256-, 384-, 864- or 1536-well,

microtitre plate arrays), pin arrays, and bead arrays (for example, in a liquid "slurry"). Arrays on

substrates such as glass or ceramic slides are often referred to as chip arrays or "chips." Such

arrays are well known in the art. In one embodiment of the present invention, the Prostate Cancer

Prognosticarray is a chip.

DATA ANALYSIS

Array data can be managed and analyzed using techniques known in the art. The Genetrix suite

of tools can be used for microarray analysis (Epicenter Software, Pasadena, CA). Probe set

modeling and data pre-processing can be derived using the Robust Multi-Array (RMA)

algorithm or variant GC-RMA, Probe Logarithmic Intensity Error (PLIER) algorithm or variant

iterPLIER. Variance or intensity filters can be applied to pre-process data using the RMA

algorithm, for example by removing target sequences with a standard deviation of < 10 or a

mean intensity of < 100 intensity units of a normalized data range, respectively.

In some embodiments, one or more pattern recognition methods can be used in analyzing the

expression level of target sequences. The pattern recognition method can comprise a linear

combination of expression levels, or a nonlinear combination of expression levels. In some

embodiments, expression measurements for RNA transcripts or combinations of RNA transcript

levels are formulated into linear or non-linear models or algorithms (i.e., an 'expression

signature') and converted into a likelihood score. This likelihood score indicates the probability

that a biological sample is from a patient who will exhibit no evidence of disease, who will

exhibit systemic cancer, or who will exhibit biochemical recurrence. The likelihood score can be

used to distinguish these disease states. The models and/or algorithms can be provided in

machine readable format, and may be used to correlate expression levels or an expression profile

with a disease state, and/or to designate a treatment modality for a patient or class of patients.

Thus, results of the expression level analysis can be used to correlate increased expression of

RNAs corresponding to SEQ ID NOs: 1-21 14, or subgroups thereof as described herein, with

prostate cancer outcome, and to designate a treatment modality.

Factors known in the art for diagnosing and/or suggesting, selecting, designating, recommending

or otherwise determining a course of treatment for a patient or class of patients suspected of

having prostate cancer can be employed in combination with measurements of the target

sequence expression. These techniques include cytology, histology, ultrasound analysis, MRI

results, CT scan results, and measurements of PSA levels.

Certified tests for classifying prostate disease status and/or designating treatment modalities are

also provided. A certified test comprises a means for characterizing the expression levels of one

or more of the target sequences of interest, and a certification from a government regulatory

agency endorsing use of the test for classifying the prostate disease status of a biological sample.

In some embodiments, the certified test may comprise reagents for amplification reactions used

to detect and/or quantitate expression of the target sequences to be characterized in the test. An

array of probe nucleic acids can be used, with or without prior target amplification, for use in

measuring target sequence expression.

The test is submitted to an agency having authority to certify the test for use in distinguishing

prostate disease status and/or outcome. Results of detection of expression levels of the target

sequences used in the test and correlation with disease status and/or outcome are submitted to the

agency. A certification authorizing the diagnostic and/or prognostic use of the test is obtained.

Also provided are portfolios of expression levels comprising a plurality of normalized expression

levels of the target sequences described herein, including SEQ ID NOs: 1-21 14. Such portfolios

may be provided by performing the methods described herein to obtain expression levels from an

individual patient or from a group of patients. The expression levels can be normalized by any

method known in the art; exemplary normalization methods that can be used in various

embodiments include Robust Multichip Average (RMA), probe logarithmic intensity error

estimation (PLIER), non-linear fit (NLFIT) quantile-based and nonlinear normalization, and

combinations thereof. Background correction can also be performed on the expression data;

exemplary techniques useful for background correction include mode of intensities, normalized

using median polish probe modeling and sketch-normalization.

In some embodiments, portfolios are established such that the combination of genes in the

portfolio exhibit improved sensitivity and specificity relative to known methods. In considering

a group of genes for inclusion in a portfolio, a small standard deviation in expression

measurements correlates with greater specificity. Other measurements of variation such as

correlation coefficients can also be used in this capacity. The invention also encompasses the

above methods where the specificity is at least about 50% or at least about 60%. The invention

also encompasses the above methods where the sensitivity is at least about 90%.

The gene expression profiles of each of the target sequences comprising the portfolio can fixed

in a medium such as a computer readable medium. This can take a number of forms. For

example, a table can be established into which the range of signals (e.g., intensity measurements)

indicative of disease or outcome is input. Actual patient data can then be compared to the values

in the table to determine the patient samples diagnosis or prognosis. In a more sophisticated

embodiment, patterns of the expression signals (e.g., fluorescent intensity) are recorded digitally

or graphically.

The expression profiles of the samples can be compared to a control portfolio. If the sample

expression patterns are consistent with the expression pattern for a known disease or disease

outcome, the expression patterns can be used to designate one or more treatment modalities. For

patients with test scores consistent with systemic disease outcome after prostatectomy, additional

treatment modalities such as adjuvant chemotherapy (e.g., docetaxel, mitoxantrone and

prednisone), systemic radiation therapy (e.g., samarium or strontium) and/or anti-androgen

therapy (e.g., surgical castration, finasteride, dutasteride) can be designated. Such patients would

likely be treated immediately with anti-androgen therapy alone or in combination with radiation

therapy in order to eliminate presumed micro-metastatic disease, which cannot be detected

clinically but can be revealed by the target sequence expression signature. Such patients can also

be more closely monitored for signs of disease progression. For patients with test scores

consistent with PSA or NED, adjuvant therapy would not likely be recommended by their

physicians in order to avoid treatment-related side effects such as metabolic syndrome (e.g.,

hypertension, diabetes and/or weight gain) or osteoporosis. Patients with samples consistent

with NED could be designated for watchful waiting, or for no treatment. Patients with test

scores that do not correlate with systemic disease but who have successive PSA increases could

be designated for watchful waiting, increased monitoring, or lower dose or shorter duration anti-

androgen therapy.

Target sequences can be grouped so that information obtained about the set of target sequences

in the group can be used to make or assist in making a clinically relevant judgment such as a

diagnosis, prognosis, or treatment choice.

A patient report is also provided comprising a representation of measured expression levels of a

plurality of target sequences in a biological sample from the patient, wherein the representation

comprises expression levels of target sequences corresponding to any one, two, three, four, five,

six, eight, ten, twenty, thirty, fifty or more of the target sequences depicted in SEQ ID NOs: 1-

2 114, or of the subsets described herein, or of a combination thereof. In some embodiments, the

representation of the measured expression level(s) may take the form of a linear or nonlinear

combination of expression levels of the target sequences of interest. The patient report may be

provided in a machine (e.g., a computer) readable format and/or in a hard (paper) copy. The

report can also include standard measurements of expression levels of said plurality of target

sequences from one or more sets of patients with known disease status and/or outcome. The

report can be used to inform the patient and/or treating physician of the expression levels of the

expressed target sequences, the likely medical diagnosis and/or implications, and optionally may

recommend a treatment modality for the patient.

Also provided are representations of the gene expression profiles useful for treating, diagnosing,

prognosticating, and otherwise assessing disease. In some embodiments, these profile

representations are reduced to a medium that can be automatically read by a machine such as

computer readable media (magnetic, optical, and the like). The articles can also include

instructions for assessing the gene expression profiles in such media. For example, the articles

may comprise a readable storage form having computer instructions for comparing gene

expression profiles of the portfolios of genes described above. The articles may also have gene

expression profiles digitally recorded therein so that they may be compared with gene expression

data from patient samples. Alternatively, the profiles can be recorded in different

representational format. A graphical recordation is one such format. Clustering algorithms can

assist in the visualization of such data.

KITS

Kits for performing the desired method(s) are also provided, and comprise a container or housing

for holding the components of the kit, one or more vessels containing one or more nucleic

acid(s), and optionally one or more vessels containing one or more reagents. The reagents

include those described in the composition of matter section above, and those reagents useful for

performing the methods described, including amplification reagents, and may include one or

more probes, primers or primer pairs, enzymes (including polymerases and ligases), intercalating

dyes, labeled probes, and labels that can be incorporated into amplification products.

In some embodiments, the kit comprises primers or primer pairs specific for those subsets and

combinations of target sequences described herein. At least two, three, four or five primers or

pairs of primers suitable for selectively amplifying the same number of target sequence- specific

polynucleotides can be provided in kit form. In some embodiments, the kit comprises from five

to fifty primers or pairs of primers suitable for amplifying the same number of target sequence-

representative polynucleotides of interest.

The primers or primer pairs of the kit, when used in an amplification reaction, specifically

amplify at least a portion of a nucleic acid depicted in one of SEQ ID NOs: 1-21 14 (or subgroups

thereof as set forth herein), an RNA form thereof, or a complement to either thereof. The kit

may include a plurality of such primers or primer pairs which can specifically amplify a

corresponding plurality of different nucleic acids depicted in one of SEQ ID NOs: 1-21 14 (or

subgroups thereof as set forth herein), RNA forms thereof, or complements thereto. At least two,

three, four or five primers or pairs of primers suitable for selectively amplifying the same

number of target sequence- specific polynucleotides can be provided in kit form. In some

embodiments, the kit comprises from five to fifty primers or pairs of primers suitable for

amplifying the same number of target sequence-representative polynucleotides of interest.

The reagents may independently be in liquid or solid form. The reagents may be provided in

mixtures. Control samples and/or nucleic acids may optionally be provided in the kit. Control

samples may include tissue and/or nucleic acids obtained from or representative of prostate

tumor samples from patients showing no evidence of disease, as well as tissue and/or nucleic

acids obtained from or representative of prostate tumor samples from patients that develop

systemic prostate cancer.

The nucleic acids may be provided in an array format, and thus an array or microarray may be

included in the kit. The kit optionally may be certified by a government agency for use in

prognosing the disease outcome of prostate cancer patients and/or for designating a treatment

modality.

Instructions for using the kit to perform one or more methods of the invention can be provided

with the container, and can be provided in any fixed medium. The instructions may be located

inside or outside the container or housing, and/or may be printed on the interior or exterior of any

surface thereof. A kit may be in multiplex form for concurrently detecting and/or quantitating

one or more different target polynucleotides representing the expressed target sequnces.

DEVICES

Devices useful for performing methods of the invention are also provided. The devices can

comprise means for characterizing the expression level of a target sequence of the invention, for

example components for performing one or more methods of nucleic acid extraction,

amplification, and/or detection. Such components may include one or more of an amplification

chamber (for example a thermal cycler), a plate reader, a spectrophotometer, capillary

electrophoresis apparatus, a chip reader, and or robotic sample handling components. These

components ultimately can obtain data that reflects the expression level of the target sequences

used in the assay being employed.

The devices may include an excitation and/or a detection means. Any instrument that provides a

wavelength that can excite a species of interest and is shorter than the emission wavelength(s) to

be detected can be used for excitation. Commercially available devices can provide suitable

excitation wavelengths as well as suitable detection components.

Exemplary excitation sources include a broadband UV light source such as a deuterium lamp

with an appropriate filter, the output of a white light source such as a xenon lamp or a deuterium

lamp after passing through a monochromator to extract out the desired wavelength(s), a

continuous wave (cw) gas laser, a solid state diode laser, or any of the pulsed lasers. Emitted

light can be detected through any suitable device or technique; many suitable approaches are

known in the art. For example, a fluorimeter or spectrophotometer may be used to detect

whether the test sample emits light of a wavelength characteristic of a label used in an assay.

The devices typically comprise a means for identifying a given sample, and of linking the results

obtained to that sample. Such means can include manual labels, barcodes, and other indicators

which can be linked to a sample vessel, and/or may optionally be included in the sample itself,

for example where an encoded particle is added to the sample. The results may be linked to the

sample, for example in a computer memory that contains a sample designation and a record of

expression levels obtained from the sample. Linkage of the results to the sample can also

include a linkage to a particular sample receptacle in the device, which is also linked to the

sample identity.

The devices also comprise a means for correlating the expression levels of the target sequences

being studied with a prognosis of disease outcome. Such means may comprise one or more of a

variety of correlative techniques, including lookup tables, algorithms, multivariate models, and

linear or nonlinear combinations of expression models or algorithms. The expression levels may

be converted to one or more likelihood scores, reflecting a likelihood that the patient providing

the sample will exhibit a particular disease outcome. The models and/or algorithms can be

provided in machine readable format, and can optionally further designate a treatment modality

for a patient or class of patients.

The device also comprises output means for outputting the disease status, prognosis and/or a

treatment modality. Such output means can take any form which transmits the results to a

patient and/or a healthcare provider, and may include a monitor, a printed format, or both. The

device may use a computer system for performing one or more of the steps provided.

CITATIONS

Patents and Published Applications

1. US 2003/0224399 A l patent application Methods for determining the prognosis for patients

with a prostate neoplastic condition 2003- 12-04

2 . US 2007/0048738 A l patent application Methods and compositions for diagnosis, staging

and prognosis of prostate cancer 2007-03-0 1

3 . US 2007/0099197 A l patent application Methods of prognosis of prostate cancer 2007-05-

03

4 . US 2007/0259352 A l patent application Prostate cancer-related nucleic acids 2007-1 1-08

5 . US 2008/0009001 A l patent application Method for Identification of Neoplastic

Transformation with Particular Reference to Prostate Cancer 2008-0 1-10

Publications

1: Cooper CS, Campbell C, Jhavar S . Mechanisms of Disease: biomarkers and molecular targets

from microarray gene expression studies in prostate cancer.

Nat Clin Pract Urol. 2007 Dec;4( 12):677-87. Review.

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outcomes in prostate cancer. Clin Genitourin Cancer. 2006 Dec;5(3): 187-9. Review.

3 : Nelson PS. Predicting prostate cancer behavior using transcript profiles. J Urol. 2004

Nov; 172(5 Pt 2):S28-32; discussion S33. Review.

4 : Bibikova M, Chudin E, Arsanjani A, Zhou L, Garcia EW, Modder J, Kostelec M, Barker D,

Downs T, Fan JB, Wang-Rodriguez J . Expression signatures that correlated with Gleason score

and relapse in prostate cancer. Genomics. 2007 Jun;89(6):666-72. Epub 2007 Apr 24.

5 : Schlomm T, Erbersdobler A, Mirlacher M, Sauter G . Molecular staging of prostate cancer in

the year 2007. World J Urol. 2007 Mar;25( 1): 19-30. Epub 2007 Mar 2 . Review.

6 : Mendiratta P, Febbo PG. Genomic signatures associated with the development, progression,

and outcome of prostate cancer. MoI Diagn Ther. 2007; 11(6):345-54.

7 : Reddy GK, Balk SP. Clinical utility of microarray-derived genetic signatures in predicting

outcomes in prostate cancer. Clin Genitourin Cancer. 2006 Dec;5(3): 187-9. Review.

8 : True L, Coleman I, Hawley S, Huang CY, Gifford D, Coleman R, Beer TM, Gelmann E,

Datta M, Mostaghel E, Knudsen B, Lange P, Vessella R, Lin D, Hood L, Nelson PS. A

molecular correlate to the Gleason grading system for prostate adenocarcinoma. Proc Natl Acad

Sci U S A . 2006 JuI 18; 103(29): 1099 1-6. Epub 2006 JuI 7 .

9 : Stephenson AJ, Smith A, Kattan MW, Satagopan J, Reuter VE, Scardino PT, Gerald

WL. Integration of gene expression profiling and clinical variables to predict

prostate carcinoma recurrence after radical prostatectomy.

Cancer. 2005 JuI 15; 104(2):290-8.

10: Bueno R, Loughlin KR, Powell MH, Gordon GJ. A diagnostic test for prostate cancer from

gene expression profiling data.J Urol. 2004 Feb;171(2 Pt l):903-6.

11: Yu YP, Landsittel D, Jing L, Nelson J, Ren B, Liu L, McDonald C, Thomas R, Dhir R,

Finkelstein S, Michalopoulos G, Becich M, Luo JH. Gene expression alterations in prostate

cancer predicting tumor aggression and preceding development of malignancy. J Clin Oncol.

2004 JuI 15;22(14):2790-9.

12: Feroze-Merzoug F, Schober MS, Chen YQ. Molecular profiling in prostate cancer. Cancer

Metastasis Rev. 200 1;20(3-4): 165-7 1. Review.

13: Nakagawa T, Kollmeyer TM, Morlan BW, Anderson SK, Bergstralh EJ, Davis BJ, Asmann

YW, Klee GG, Ballman KV, Jenkins RB. A tissue biomarker panel predicting systemic

progression after PSA recurrence post-definitive prostate cancer therapy. PLoS ONE. 2008;

3(5):e2318.

14: Shariat SF, Karakiewicz PI, Roehrborn CG, Kattan MW. An updated catalog of prostate

cancer predictive tools. Cancer 2008; 113(1 1): 3062-6.

EXAMPLES

To gain a better understanding of the invention described herein, the following examples are set

forth. It will be understood that these examples are intended to describe illustrative embodiments

of the invention and are not intended to limit the scope of the invention in any way. Efforts have

been made to ensure accuracy with respect to numbers used (e.g., amounts, temperature, etc.) but

some experimental error and deviation should be accounted for. Unless otherwise indicated,

parts are parts by weight, temperature is degree centigrade and pressure is at or near atmospheric,

and all materials are commercially available.

EXAMPLE 1. IDENTIFICATION O F TARGET SEQUENCES DIFFERENTIALLY EXPRESSED IN PROSTATE

DISEASE STATES

Tissue Samples. Formalin-fixed paraffin embedded (FFPE) samples of human prostate

adenocarcinoma prostatectomies were collected from patients at the Mayo Clinic Comprehensive

Cancer Center according to an institutional review board-approved protocol and stored in the

Department of Pathology for up to 20 years. For each patient sample four 4 micron sections were

cut from formalin-fixed paraffin embedded blocks. Pathological review of FFPE tissue sections

was used to guide macrodissection of tumor and surrounding normal tissue. Patients were

classified into one of three clinical disease states; no evidence of disease (NED, n=10) for those

patients with no biochemical or other clinical signs of disease progression (at least 10 years

follow-up); prostate-specific antigen biochemical recurrence (PSA, n=10) for those patients with

two successive increases in PSA measurements above an established cut-point of >4 ng/mL

('rising PSA'); and systemic disease (SYS, n=10) for those patients that had 'rising PSA' and

developed metastases or clinically detectable disease progression within five years after initial

prostatectomy. Clinical disease was confirmed using bone or CT scans for prostate cancer

metastases.

RNA Extraction. RNA was extracted and purified from FFPE tissue sections using a modified

protocol for the commercially available High Pure FFPE RNA Micro nucleic acid extraction kit

(Roche Applied Sciences, Indianapolis, IN). RNA concentrations were calculated using a

Nanodrop ND-K)OO spectrophotometer (Nanodrop Technologies, Rockland, DE).

RNA Amplification and GeneChip Hybridization. Purified RNA was subjected to whole-

transcriptome amplification using the WT-Ovation FFPE system including the WT-Ovation

Exon and FL-Ovation Biotin V2 labeling modules, with the following modifications. Fifty (50)

nanograms of RNA extracted from FFPE sections was used to generate amplified Ribo-SPIA

product. For the WT-Ovation Exon sense-target strand conversion kit 4 ug of Ribo-SPIA product

were used. All clean-up steps were performed with RNAClean magnetic beads (Agencourt

Biosciences). Between 2.5 and 5 micrograms of WT-Ovation Exon product were used to

fragment and label using the FL-Ovation Biotin V2 labeling module and labeled product was

hybridized to Affymetrix Human Exon 1.0 ST GeneChips following manufacturer's

recommendations (Affymetrix, Santa Clara, CA). Of the 30 samples processed, 22 had sufficient

amplified material (i.e., >2.5 ug of WT-Ovation Exon product) for GeneChip hybridization.

Microarray Analysis. All data management and analysis was conducted using the Genetrix

suite of tools for microarray analysis (Epicenter Software, Pasadena, CA). Probe set modeling

and data pre-processing were derived using the Robust Multi-Array (RMA) algorithm. The

mode of intensity values was used for background correction and RMA-sketch was used for

normalization and probe modeling used a median polish routine. A variance filter was applied to

data pre-processed using the RMA algorithm, by removing target sequences with a mean

intensity of < 10 intensity units of a normalized data range. Target sequences typically comprise

four individual probes that interrogate the expression of RNA transcripts or portions thereof.

Target sequence annotations and the sequences (RNAs) that they interrogate were downloaded

from the Affymetrix website (www.netaffx.com). Supervised analysis of differentially expressed

RNA transcripts was determined based on the fold change in the average expression (at least 2

fold change) and the associated t-test, with a p-value cut-off of p<0.001 between different

prostate cancer patient disease states. Linear regression was also used to screen differentially

expressed transcripts that displayed an expression pattern of NED>PSA>SYS or

SYS>PSA>NED and genes were selected with a p-value cut-off of p<0.01 for two-way

hierarchical clustering using Pearson's correlation distance metric with complete-linkage cluster

distances.

Archived FFPE blocks of tumors were selected from 30 patients that had undergone a

prostatectomy at the Mayo Clinic Comprehensive Cancer Center between the years 1987- 1997,

providing for at least 10 years follow-up on each patient. Twenty-two patient samples had RNA

of sufficient quantity and quality for RNA amplification and subsequent GeneChip hybridization.

Three clinical categories of patients were evaluated; patients alive with no evidence of disease

('NED', n=6), patients with rising PSA or biochemical recurrence (defined as two successive

increases in PSA measurements) ('PSA', n=7) and patients with rising PSA and clinical evidence

of systemic or recurrent disease (e.g., determined by bone scan, CT) ('SYS', n=9) after

prostatectomy. No statistically significant differences between these three clinical groups were

apparent when considering pathological factors such as Gleason score or tumor stage (Table 1).

As samples from older archived FFPE blocks are typically more degraded and fragmented than

younger blocks, the distribution of block ages was similar in the three clinical groups so as not to

skew or bias the results due to a block age effect. Fifty nanograms of RNA extracted from FFPE

sections was amplified and hybridized to whole-transcriptome microarrays, interrogating > 1.4

million probe target sequences measuring RNA levels for RefSeq, dbEST and predicted

transcripts (collectively, 'RNAs').

Table 3 displays the number of target sequences identified in two-way comparisons between

different clinical states using the appropriate t-tests and a p-value cut-off of p<0.001 . At total of

2,1 14 target sequences (Table 3) were identified as differentially expressed in these comparisons

and a principle components analysis demonstrates that these target sequences discriminate the

distinct clinical states into three clusters (Figure IA).

A linear regression filter was next employed to statistically rank target sequences that followed a

trend of either increased expression with poor prognosis patients (i.e., SYS>PSA>NED) or

increased expression in good prognosis patients (NED>PSA>SYS, alternatively decreased

expression in poor prognosis patients) (Table 4). Figure IB depicts a two-way hierarchical

clustering dendrogram and expression matrix of top-ranked 526 target sequences and 22 tumor

samples. Patients in the 'PSA' clinical status category displayed intermediate expression levels

for genes expressed at increased levels in SYS (n=3 13) and NED (n=213), respectively (Table

4). Figure 1C depicts a two-way hierarchical clustering dendrogram and expression matrix of

148 target sequences and 22 tumor samples. These target sequences were a subset of the

differentially expressed transcripts (Table 3) filtered using a t-test to query 'recurrent' (i.e.,

'SYS') and 'non-recurrent' (i.e., 'PSA' and 'NED') patient samples (Table 5).

The expression levels of these genes were summarized for each patient into a 'metagene' using a

simple linear combination by taking the expression level and multiplying it by a weighting factor

for each target sequence in the metagene signature and combining these values into a single

variable. Weighting factors were derived from the coefficients of the linear regression fit analysis

(Table 4). Figure 2 shows a histogram plot of the metagene expression values for the

summarized 526 target sequences in each of the three clinical groups. This 526-metagene

achieved maximal separation between clinical groups and low variance within each clinical

group. Metagenes comprised of smaller subsets of 21, 18 and 6 target sequences were also

generated (Figure 3, Tables 7 and 8). The distinctions between clinical groups with respect to the

metagene scores were preserved, although increased within-group variance was observed when

using fewer target sequences (Figure 3).

Next, Patient outcome predictor ('POP') scores were generated from the metagene values for

each patient. For the 18-target sequences metagene, this entailed scaling and normalizing the

metagene scores within a range of 0 to 100, where a value of between 0-20 points indicates a

patient with NED, 40-60 points a patient with PSA recurrence and 80-100 points a patient with

SYS metastatic disease (Figure 4). In contrast, Gleason scores for patients could not be used on

their own to distinguish the clinical groups (Table 1).

Using the Nearest Shrunken Centroids (NSC) algorithm with leave- 1-out cross-validation,

smaller subsets of RNA transcripts were identified that distinguish 'recurrent' (i.e., 'SYS') and

'non-recurrent' (i.e., 'PSA' and 'NED') disease (Tables 9 and 10). NSC algorithm identified 10-

and 4 1-target sequence metagenes used to derive patient outcome predictor scores scaled and

normalized on a data range of 0-100 points. Figures 5 and 6 depict box plots showing

interquartile range and distribution of 'POP' scores for each clinical group. A 148-target

sequence metagene (Table 5) was similarly used to derive 'POP' scores depicted in Figure 7 . T-

tests were used to evaluate the statistical significance of differences in POP scores between

'recurrent' (i.e., 'SYS') and non-recurrent (i.e., 'PSA' and 'NED') patient groups (indicated in

the figures) and show that increasing the number of target sequences in the metagene

combination increases the significance level of the differences in POP scores.

The data generated from such methods can be used to determine a prognosis for disease

outcome, and/or to recommend or designate one or more treatment modalities for patients, to

produce patient reports, and to prepare expression profiles.

Table 1. Clinical characteristics of different clinical status patient groups evaluated. Note Chi

square tests for homogeneity reveal that the three clinical groups do not show significant

differences in terms of patient composition based on known prognostic variables such as

pathological TNM stage or Gleason score. Also, the block age of the samples was not different

between clinical status groups; so that sample archive age effect is mitigated (i.e., older samples

have more degraded, fragmented nucleic acids that could skew or bias results if not evenly

distributed in clinical status patient groups).

NED PSA Systemic X2 Tests for(n=6) (n=7) (n=9) Homegeneity

PathologicalStage T2N0 2 3 3 jx θ.07

T3aN0 1 4 1T3bN0 0 0 3TxN+ 3 0 2

Gleason Score 7 2 7 4 jx θ.068 3 0 2

9 1 0 3

10-14 3 4 5Block Age jx θ.913-15 1 1 2

Group (years)16-20 2 2 2

Table 2 . Comparison of differential expression between patient clinical status groups. Two-way

comparisons for differential expression using the following statistical criteria: a) at least 2-fold

mean difference in expression between comparison groups; b) expression levels > 50 intensity

units of a normalized data range (approximately the mean expression level across all transcripts

in all samples) and c) significance cut-off of p<0.001 determined using a t-test.

ClinicalComparison Differentially Expressed RNAs

Status

NED vs PSA 316PSA vs NED 442NED vs SYS 213PSA vs SYS 194SYS vs NED 269SYS vs PSA 323SYS vs NED & PSA 310

NED & PSA vs SYS 77

Differential Expression is indicated by at least 2-fold change expression betweenmean of clinical status variable and comparison variable; also mean value > 50intensity units of a normalized data range and p<0.001 calculated using a t-test

Tab

le3

.D

iffe

rent

ially

expr

esse

dR

NA

tran

scri

pts

iden

tifie

dfr

omco

mpa

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nte

sts

desc

ribe

din

Tab

le2

.Se

quen

celis

tings

are

anno

tate

dw

ithth

e

Aff

ymet

rix

Hum

anE

xon

1.0

ST

prob

ese

lect

ion

regi

onID

,pr

oxim

alan

nota

ted

gene

from

Ref

Seq,

and

over

lap

with

codi

ngse

quen

ce(C

DS)

.

SEQ

Aff

y.ID

Gen

eC CD

DSS

RN

ASe

quen

ceID

Sym

bol

No

135

0927

8—

NO

ctgg

tccc

tctc

ctga

taga

gtttc

aggt

ttgcc

ctga

tgat

ctag

atga

agca

aagt

gtgg

tgac

acttc

gctg

aatg

ctct

gtca

gtgt

gcct

agaa

atag

agtc

tcta

tcag

ggcc

gtttg

cttc

ctat

caca

ctc

227

5044

0N

Ogg

catg

atct

aggc

taac

tccc

tggc

334

9866

5__

_N

Otg

ggca

agag

ctttt

gtat

gtttc

cag

431

5953

2—

NO

ccca

acac

ggtg

cagc

cgat

ttattt

atttt

tccc

tcag

cattt

ttagg

tgga

ttgac

tggg

atgc

tttat

tcaa

ctca

ggga

cgca

ccac

gaat

atgt

tttttg

535

2160

0U

GC

GL

YE

Stg

gcgc

cagc

gaaa

gcca

cgaa

cgtg

2

638

2059

7—

NO

gctg

ggcg

cagc

gttc

tgag

ggga

tgtg

gggt

ctgg

gagg

tgtc

tcga

ggtg

agag

ctcc

aagt

cacg

g

739

5534

9N

Ogt

ggcg

caat

attg

caat

acag

ctca

ctgc

taca

gccc

cagg

ctta

agtg

atct

tcttg

cctc

agtc

tccc

gagt

agct

ggaa

ccac

aatc

tcat

acca

ccac

gccc

cacg

cctg

gtaa

atttt

taaa

tgttt

ttgta

aaga

cagg

gtac

tgct

gtgt

tgcc

cagg

ctgg

tctc

taat

tcct

agtc

tcaa

gcga

tcct

tccg

ctttg

gcc

tccc

aaag

cact

ggga

ttaca

ggtg

tgag

ccac

tgtg

ccca

gccc

tgct

ctag

gtttt

cattt

ggat

ttgct

gcct

agtg

gaag

gcac

agga

tggg

gcag

tgcc

ttctg

ccag

tgag

ggag

gctc

cagg

taga

tgtc

attg

ctga

actg

gagc

tccc

ctgg

832

0452

3PI

GO

YE

Stg

cttc

ctct

tcta

cgct

ggca

ttgcc

ctct

tcac

cagt

ggct

tcct

gctc

accc

gtttg

gagc

tcac

caac

cata

gcag

ctgc

caag

agcc

ccca

ggcc

ctg

ggtc

cctg

ccat

gggg

gagc

caag

ggaa

acct

gggg

cctg

ctgg

atgg

cttc

ccga

ttttc

gcgg

gttg

tgttg

gtgc

tgat

agat

gctc

tgcg

atttg

actt

cgcc

cagc

ccca

gcat

tcac

acgt

gcct

agag

agcc

tcct

gtct

ccct

accc

ttcct

gggc

aaac

taag

ctcc

ttgca

gagg

atcc

tgga

gattc

agcc

cca

ccat

gccc

ggct

ctac

cgat

ctca

ggtt

933

7389

9SL

C43

AN

Oag

ccat

ggcc

gtag

attta

taaa

tacc

aaga

gaag

ttcta

tttttg

taaa

gact

gcaa

aaag

gagg

aaaa

aaaa

ccttc

aaaa

acgc

cccc

taag

tcaa

cgct

1cc

attg

actg

aaga

cagt

ccct

atcc

taga

gggg

ttgag

ccttc

ttcct

ccttg

ggttg

gagg

agac

cagg

gtgc

ctct

tatc

tcct

tcta

gcgg

tctg

cctc

ctgg

tacc

tcttg

gggg

gatc

ggca

aaca

ggct

accc

ctga

ggtc

ccat

gtgc

catg

agtg

tgca

caca

tgca

tgtg

tctg

tgta

tgtg

tgaa

tgtg

agag

aga

caca

gccc

tcct

ttc

1037

0764

5R

AB

EP

YE

Sat

ggcg

cagc

cggg

cccg

gcttc

cc1

11

3860

354

LO

ClO

ON

Ottc

agat

tcac

gagg

gtaa

tcca

gatg

aagg

tata

tcat

tgta

cctg

gccc

gcat

cact

cagt

aact

gtca

ccttt

gattt

attg

attta

cttg

agat

ggag

tttgg

t12

7980

tctg

tccc

cgag

gccg

gagt

gcaa

tggc

gtga

tctc

tgct

cact

acaa

cctc

tgcc

tccc

aggt

tcag

agtg

attc

tcct

gcct

cagc

ctct

ttagc

tggg

att

acag

gcac

ccac

caac

atgc

ccag

ctaa

tttttg

tattt

ttagt

agag

agga

gcttt

cacc

ataa

tggc

cagg

ctgg

tcttg

aacc

tcaa

atga

tctg

ccca

cct

tggc

ctcc

caaa

gtgc

tagg

atta

cagg

ctgg

agct

acag

agcc

cagc

ctgt

cacc

ttgat

ttaaa

tgaa

tgca

gcttt

cttg

gtgt

cttg

atgt

ttgtg

aattt

ctgt

ggag

tttga

tact

gctc

ctttt

gctg

cttg

tttttc

caga

gtcc

cctta

tcac

ttgac

gtgc

tgtta

ta

1224

0677

2M

RPS

lN

Otg

tcgt

gaca

gcct

ctct

ttggg

gcca

gcttc

tgct

tttgc

cccc

atct

ttgca

gtac

aggg

ggta

aatta

aaca

agag

gatg

cctg

aatg

aacg

atat

cctg

g5

gttc

ttgag

agac

aagt

ggga

gctg

ataa

ttctg

aaaa

ttcat

tagt

caaa

gcat

ggag

ataa

aggt

ggca

gcag

gaag

ggga

gagg

caag

gagt

agac

ccg

tgac

agttt

taga

atct

tattt

gtgc

caaa

atac

tttac

tgca

ttggc

ttgga

cctc

taat

acaa

tgttg

aattg

ttaac

catg

atag

cact

gtat

cctg

gtct

aatt

cctg

aattg

aatg

gcta

gtct

tacc

atta

agaa

tgct

atttg

cggc

cagg

c

1338

8132

4H

Ml

3Y

ES

ttatg

aattt

gaca

ccaa

ggac

ctgg

tgtg

cctg

ggcc

tgag

cagc

atcg

ttggc

gtct

ggta

cctg

ctga

g14

3271

321

—N

Oag

gagc

aggt

cgtc

aagt

ccac

cagg

atgg

aatg

ctca

gtag

gaga

aattg

cgct

gtgg

ggcc

atttg

aggc

gcct

gtcc

atgc

gggt

ccgt

cctg

gccc

ttctg

aa

1533

1637

4—

NO

aggc

atta

cgcc

agct

cccg

gatg

cctc

agcc

tcgt

gaat

tcgg

ggta

ggac

gctc

aggg

ccca

tggt

cagc

acag

cggg

tggg

tggg

tttca

gcgt

ggt

cact

tctc

cagg

ggtg

cata

attg

agca

gcttc

tcga

tcag

gtcc

acgt

g

1633

3369

5—

NO

gttg

agga

gcttg

atgc

tgca

gtga

gattg

tgcc

actg

cact

ccag

catg

ggtg

acat

agca

agac

tgcc

tcag

gggg

aaaa

aaaa

aaaa

aaac

acca

aaaa

aaaa

ggta

tatg

gacc

ctag

ttttg

gcca

ggct

g

1739

3085

5...

NO

gtgg

ctca

ctgt

agcg

tcag

tctc

c18

2945

934

CM

AH

NO

ggac

gattc

gtttc

tattt

gacc

caag

actg

atgc

tgcg

tggt

gaag

gaga

ggaa

ctgc

gttc

cagg

caga

ggaa

gtcc

agat

gcgc

aaga

gcag

agat

ggg

aggg

acag

caca

gtgg

cttc

tcag

aattg

aata

tggt

gtta

gact

tcta

aaag

agct

gtgg

taga

ggga

gaaa

actg

tcaa

agga

aatc

agta

actg

ttaaa

ggaa

aata

cctta

aacg

tcct

gtttt

cagg

ctga

ctaa

tgcc

ttagg

ggag

caaa

tgag

caac

a

1925

8140

5N

Ottg

gtat

gtag

ggttc

gtat

gaat

gaaa

cgtg

acta

ccag

ggca

gata

atga

aagg

ctttc

aatc

ccag

agta

agag

atat

aggg

ccag

gc20

2465

840

...N

Oat

gtgg

caca

attta

cgaa

aacc

aaag

agag

gcta

tgct

gagt

ccct

acac

cacc

aaga

ccgt

gatg

ttctg

ccca

ctcg

cctc

ctga

tggc

ctgt

gggg

atag

acca

gcttc

caga

tttca

caca

gatg

ggct

gtat

ggag

gagg

c

21

3431

367

...N

Ocg

atct

ctca

tggt

gggc

tcaa

gtga

tcct

ccca

tctc

agcc

tccc

aagc

acct

ggga

ctac

aggt

gcac

atca

acac

accc

ggat

aatt

2234

5811

4N

AC

AN

Ogg

gcca

ctgt

tcct

caag

catc

taaa

gggc

ttcca

gcaa

agaa

aggc

ccca

cagc

tctg

aaag

aagt

acttg

ttgcc

ccag

ctcc

agaa

agca

cgcc

aat

catc

acag

ctcc

cact

cgga

aagg

tcca

caga

ccaa

aaag

agttc

tgct

acttc

acct

ccta

tatg

ccca

gatc

cctc

agct

aaga

atgg

2338

7525

4...

NO

ttctc

cctc

agac

caag

ttaaa

ctgt

tttttt

ccca

agag

ctag

gaat

cata

tctg

atca

cact

ggga

cttc

ccttc

actg

tcag

tcta

agag

tttgc

atttt

tgag

gttta

ggaa

aagg

gaaa

aaaa

agga

agaa

agaa

agaa

attg

tatc

tgag

aaca

aaga

agct

gcca

catg

gtcc

ctcg

gtat

ca24

2515

646

ITG

A6

YE

Stg

tgct

cacc

gata

tgaa

aaaa

ggca

gcat

gtta

atac

gaag

cagg

aatc

ccga

gaca

tcttt

gggc

ggtg

ttatg

tcct

gagt

caga

atct

cagg

attg

aag

acga

tatg

gatg

25

3202

904

—N

Otg

aggg

cgttg

gacc

acac

accc

ttgaa

aaag

gcct

cgcc

ccgc

tcat

ctct

gaag

atct

tcct

ccaa

cagt

cgac

ggtg

cccg

tgta

catg

atgt

cagc

tcct

ttgcg

ccgg

gact

gcat

catc

gtcc

gccg

ccgc

actg

tgtc

gaag

ggtta

g

2627

6830

4N

FXL

lY

ES

ctgt

ccac

cttg

tgat

caaa

actg

tgga

cgga

cttta

g27

3736

631

—N

Oaa

agcg

gtca

ctgg

ccat

atga

tgcg

gaga

tggt

tttat

ctga

ggcc

tgag

aacc

aaca

gatg

tgcc

tgcg

ccct

ggcc

tgtg

cagc

tgtg

ggca

gatg

tgtc

ccca

gggg

cctg

ccct

cact

cgtg

acca

tgca

atac

cctg

caac

ataa

acat

tttct

tttcc

aagg

atct

gcag

gggt

ggac

atga

tgct

ccag

gcac

agag

tagg

aaga

aaag

gggg

tgac

ctgg

ggttc

ccag

caaa

cagg

tcca

cctc

atgc

tcac

tgcg

tt

28

2787

529

INPP

4BY

ES

tgtg

ccct

ggta

tgtg

aatg

taca

gccc

cgga

aagt

gtga

gcgg

aaaa

gata

actta

cct

2929

8018

8__

_N

Ottt

cccc

acaa

attg

ctga

tgta

cc30

3273

235

—N

Oca

atat

tcac

tgtg

aggt

caag

ctcc

taga

ggta

aaaa

ctca

aaac

tgtg

gcag

ccct

cccc

cgtg

actg

ggtc

cctc

tgaa

gtttc

taac

tctc

agag

ttgtc

cata

ctgg

gcat

ctag

cgat

tcat

31

3402

918

USP

5Y

ES

gagg

aaaa

gatc

aagt

gcct

ggcc

acag

agaa

ggtg

aagt

acac

ccag

cgag

ttgac

taca

tcat

gcag

3235

2922

7—

NO

cgaa

gtgg

gtct

ccaa

attc

cgcg

ccca

cccc

accg

cccg

agaa

gccc

acta

cgca

tgcg

tccg

cacc

ccac

cggc

gccc

cttc

ctat

tgag

catg

cgc

ggga

gccc

cacc

tattt

ctct

ctac

cgttt

cctc

cccc

tacc

tggt

accc

catc

ccta

gctc

agcc

attg

ctttt

ttttc

cacg

accc

tccg

ctgt

ttcttc

cgcg

agc

ttcct

33

3839

571

KL

K2

NO

ggag

ggaa

tggc

tgtg

tccc

acag

gaat

aaca

gcgg

gatg

cttc

c34

2697

538

CE

P70

NO

gaga

ctcg

ttggg

tgat

cattt

cattg

agat

caac

ctga

atga

ccag

gtgt

aaag

tgca

agag

taat

atgc

tatg

actg

a3

525

2107

6N

Ogg

atcc

atgc

caga

caac

gcac

attc

tgca

gaca

ctgg

ttact

ccag

tggc

tcct

tact

ggaa

acat

ataa

tatc

agtg

ataa

gtgc

tgtg

aaga

aaat

aaaa

caat

gatg

tgct

ggta

tgga

ttttta

acttt

tttat

gtga

tgaa

ccac

agaa

tgat

ggttt

taaa

tgta

tgaa

atac

atag

aattg

caac

agaa

acca

gtta

tgaa

ataa

tgaa

gata

ttaaa

tatg

acat

ctat

atttt

agta

aagc

atta

gtga

ggac

tgta

aatg

atct

ttaaa

gaat

ttggc

ttaaa

tttaa

tcta

aaat

tgct

atca

ggta

tttc

acat

cgct

gtaa

tttttg

cctg

cattc

gtaa

ctga

agag

ataa

gtaa

atgt

caga

ggtta

agat

aaat

ctttt

tcttt

tttta

cctg

tcca

tattt

acaa

acat

tctg

cgt

tccg

taca

taga

cgcc

tgga

taag

aacc

cctg

tgca

agaa

tgac

tttgg

tgct

acttt

aaaa

aaag

tggt

tggg

gaag

acct

cata

ggaa

atga

catc

aat

aata

gattg

catg

ataa

ccta

tact

agttc

ttact

gtta

ccaa

tttaa

attc

taac

tgct

taaa

agct

aaca

cggt

ccttc

ccttt

ttttg

agca

cctg

atttg

aagt

acttt

gagt

aggc

ctca

agtg

tcgt

atgc

aagt

a

3628

1102

9N

Oct

gagt

tctg

atttg

gagc

agcc

tgtc

gcaa

tacc

aaat

cacc

tttga

ataa

actta

tcct

ctca

gcttt

tattg

ttcag

aattg

atttc

gagg

atag

aaat

tcca

tttcc

ttgtc

atat

atac

ctga

gccg

ttgca

tcaa

attg

tcag

a

3727

3592

0N

Ogg

gtgt

agcg

cacc

aagc

atga

gctg

aa

3838

4376

7Z

NF1

35N

Oaa

taac

ctag

catg

gggc

ggca

ctaa

atgg

ctgc

agga

aagc

cgag

tcttc

ttcca

catc

cggc

ggct

cccc

tcgg

atgc

gagc

gctg

gccc

aggg

tgt

gttta

caga

ggtg

aggg

cttc

ccgt

ggac

ccttc

tcgt

tggg

agcg

ctta

gcct

cagg

agcg

gattc

aggg

caca

ggca

gagg

acgt

ccac

aaac

acca

cagg

aagc

cgcc

accc

aggg

gcgt

ggaa

aggc

ccaa

tgcc

tcgt

ctgg

gattc

acgg

ccgg

caaa

gcgg

cccc

tccg

gaac

ggga

cagc

acag

cggc

tcac

ctct

gcgc

ctct

gggg

gtgc

gggg

ggag

cctc

gccc

tcca

cgct

ctct

gggg

gacc

gccc

gccc

tagc

cccc

gcct

gggc

ttcgc

gggt

gga

cggt

tggg

ggcc

ccgg

gcgc

cccc

cagc

gcgt

agct

tttct

ccttc

tcgt

gggt

cttc

tggt

gctc

ggct

aggg

ccag

gctg

aagt

ggaa

ggtc

ttcca

gcag

ccct

gaca

ggcg

tagc

gcttc

cggc

cgcc

atgg

ctgc

tgtg

gtgc

tcca

tcag

gtgc

gaga

gcca

cgcg

aagg

cctc

cccg

cact

cgcc

gcag

gca

tagg

gcttc

ccgc

ggga

caag

cccg

gctc

gtca

gccc

cagg

gccc

tgcc

cggc

ctcc

agcc

ctgc

gctg

tcgc

cgga

gcta

gaga

cgcc

ctcg

aggc

tct

gccc

gtcc

ccat

cctc

gggg

tgcg

gcct

cttg

gttc

ccag

tttcg

ccgt

gccc

ctgt

ccgg

ggca

ggct

gctg

gatg

acgg

actg

cctc

tgcg

atcc

ggt

ggca

gagt

cgga

ctcc

gcgt

cctg

gggg

tcct

gcgg

gtcc

gggg

ccttc

ccag

gctg

ctct

tcct

cctc

ctca

gtgg

tgcc

cgac

gggg

gatc

ggca

aggg

cgtc

ccca

gggg

gcgc

ctcc

gtag

gcag

ctca

ggca

gcac

cccc

gcgg

gggc

ggcc

tcct

cgca

ggcg

cacc

cagc

gctc

tcct

gccg

cctc

ccgc

cttc

tgga

acaa

ggtc

agag

ccct

agcg

tgag

cgcc

c

3938

9527

5Pr

oSA

PiN

Otg

ggca

ctcg

gcat

tttga

caca

tgtc

ctgt

caaa

aggc

caga

gtcc

ccag

tgtc

ccct

cccc

tcca

tctc

tcttc

ccca

taga

cccc

ataa

cccc

agac

caa

Pl

agag

gttc

tcta

agca

gctg

tgac

cagg

ttcct

ccct

cccc

acct

gccc

tcct

agct

ccag

cact

gccc

ccgt

ggca

gccc

acttg

gacc

cccc

taaa

agg

aggg

aata

ggag

gagg

gcag

ggtg

agtg

gggg

caat

ccta

ggtg

gtgg

ggga

gtca

tgct

ccct

ttctc

ggca

cccc

cttg

ttgga

gatg

gagg

cagc

aga

cgtg

cagt

gcca

taag

gtgc

ccca

gtcc

ttctg

gagg

cctg

ggct

gcta

ctgt

tggc

cacc

ctgt

gtct

agtg

atgc

tctc

tgtg

ctca

cctc

ctag

gcca

tgg

agcc

tgag

gggg

cctg

cacc

aggt

ttgct

gaaa

ctga

caga

gcct

gggc

tcca

gacc

tctc

tccc

tcct

acag

tgct

ctcc

ctcc

ctgg

gcag

attg

gcag

gaca

agtg

ggag

caga

tggc

ctgc

ctttg

gctg

agag

ggct

acct

gccc

agcc

cctc

cccc

aaca

agat

ctct

tgga

ctca

ggcc

tcag

agcc

tggc

ctgg

ttgtg

agtg

tgtg

tccc

tgtg

tgtg

tgttg

cggg

aggg

gagg

actg

gggc

tgga

agtc

cagc

accc

aggg

aaga

tctg

tcct

cctg

ttcttg

ggaa

gcgt

tgcc

tgac

ggct

tctc

ggct

ctac

cctc

accc

ttctg

gcca

ggat

cccg

cagg

gcaa

cagc

ccca

tctg

cttg

gctg

accc

caca

ccca

ggac

cact

gtcc

ggct

ctaa

caca

gcta

ttaag

tgct

acct

gcct

ctca

ggca

ctct

cctc

gccc

agttt

ctga

ggtc

agac

gagt

gtct

gcga

tgtc

ttccc

gcac

tcta

ttcc

ccca

gcct

ctttc

tgct

ttcat

gctc

agca

catc

atct

tcct

aggc

agtc

tcttc

ccca

aagt

ctca

ccttt

tcttc

caat

agaa

aattc

cgct

tgac

ctttg

gtgc

a

4040

3109

8C

Yor

fl5

NO

tcac

ttaac

atag

tgcc

aggg

catg

caat

tttgt

ttctta

ctct

ctgg

atgt

ggga

tatg

cgag

tgtg

tgtg

tgtg

tgtg

tgtg

tgtg

tgta

ttaag

ctttc

tgttt

ctg

Bat

gaaa

ttttc

atat

gaaa

tttac

tgga

gata

agat

taaa

ttagt

ggaa

aaac

aaga

taat

tttgc

tttct

atgt

agtg

gtca

ccaa

gtta

aaga

attg

tgcc

agtta

ttagg

caag

atag

gcttt

gaga

tttag

ggac

agtta

aattt

taca

ccaa

ctta

gtga

acat

gaga

cttc

tacc

tagt

gtta

cattt

cattt

ttaaa

taag

caat

ttaaa

aattg

gtaa

atga

tttgt

ttact

ttgat

tata

ttctg

gtat

aattt

tctg

acaa

aatta

tctg

tgtc

ttggt

cagc

attg

ttgct

agaa

tatg

tattc

agat

tttgt

ctgt

cca

taat

tgag

aaca

caga

aaaa

atct

aattt

gact

atac

ccat

ttacc

ccca

tgga

aatg

aaac

tata

ttcta

tgaa

tgaa

aaat

gattt

taat

aatg

tggt

gtat

taca

ttttc

ttcat

tcaa

gtaa

tgta

ggcc

ctga

gtag

agca

tgtta

tgaa

tattt

agttc

ctta

gtgt

tttct

cattc

aagc

ctct

cata

ttgaa

tgag

tcta

gggt

ttgga

gag

atgt

ttcac

acag

catg

tctc

ttcag

tgca

agct

gaca

gata

tcag

tgca

caat

taaa

gaaa

ctta

attg

cacc

tttca

acttg

gagt

ataa

atttt

gtat

gtat

cta

tgta

tatc

tatg

tgtg

tattt

tgtg

gttta

aggc

ttattt

acat

aata

tgtg

acat

tttac

ctca

gaaa

ttcag

tgac

tgaa

tttca

cagc

tgct

tccc

atgc

atct

ttatta

tcta

tgttt

ctga

aaaa

ctca

aata

ctaa

ctaa

tctc

ttttc

ttccc

ttagc

tgttc

ctttc

ctgt

ggttt

taaa

aaag

tgac

caga

aact

aggt

ctct

atttt

cattg

ctttg

ctgc

atat

tcttt

taac

ctgc

tttta

tc

41

2927

637

KIA

A12

YE

Sgt

ccca

cagg

atttc

ggga

atca

ag44

4238

3957

5K

LK

2Y

ES

ttctg

aagc

atca

aagc

ctta

gacc

agat

gaag

actc

cagc

catg

acct

ca4

325

6662

0T

SGA

lN

Oat

ccat

tgat

ggttt

gata

gtgg

gctg

ggaa

ggaa

agct

gtgt

tcct

ccac

atta

ggca

gcaa

a

o0

44

2959903

LOC728

NO

tcat

ttattt

gaca

gtgc

atgt

ctgc

aatg

ccgt

gctc

atca

atga

t052

45

3100926

—Y

ES

agta

acag

ctat

ccac

caat

gtca

atcc

atac

46

3853655

—N

Ogc

aggc

aata

tctc

cgca

ccttt

aat

47

3947544

—N

Oct

gctg

gaac

gaca

ccaa

ctct

ttgcc

tccc

atcc

ttggt

tgga

tatg

atttg

aaat

ttggt

aatg

tgtc

tcta

cttg

aaac

agat

gcac

tgttt

ggat

gtttt

cagg

tcgg

tgat

ctac

ttgtc

cagt

ttgat

cgct

acca

gaag

48

2466

070

ZN

F692

NO

ggat

tagt

ccgc

tcca

ctca

ctgt

cagc

atta

agtg

gggg

tgcc

caag

acgg

ggtg

gatg

gggg

gcgc

cctc

caga

cctc

tgac

cacg

gcct

cacc

gcc

actc

gacc

caac

tatg

aaga

gcgc

cccc

agct

gcac

gcca

ggac

acga

ccttt

ccttc

ccct

agaa

acca

gtaa

aggc

cgct

gccc

tattc

aaga

tgaa

atgt

gtgg

accg

cccc

cagc

ccag

ttgaa

atttc

ccgt

gaaa

gtct

ctcg

cccc

ttccc

caca

gctc

cact

tcag

tgga

ctgg

aggg

cgca

ggcc

tttgt

tctg

actg

cttc

tgtc

tgcc

tgcc

tccc

accc

gacg

acac

tcac

atgg

tagc

gctg

agct

tcaa

cacc

ctgt

a

4930

6581

8R

EL

NY

ES

ttcga

tagg

tttga

gggg

aagc

tcag

ccct

ctgt

ggta

caag

ataa

cagg

tgcc

cagg

ttgga

actg

gctg

tgga

acac

ttaac

gatg

gcaa

atct

ctct

act

tcaa

tggc

cctg

5033

3218

3ST

X3

NO

ctga

tttca

ctcc

agac

tggt

gtgg

ccac

ccttg

tcttc

agat

gaga

at5

136

8141

0PA

RN

YE

Sct

gtca

atac

cagc

aaat

atgc

agaa

agct

atcg

gatc

caaa

ccta

tgct

gaat

atat

gggg

agaa

aaca

ggaa

gaga

agca

gatc

aaaa

gaaa

gtgg

actg

aaga

tagc

tgga

agga

ggct

gaca

gcaa

acgg

ttaaa

cccc

cagt

gcat

accc

taca

ccct

gcag

aatc

acta

ttacc

g

5238

7334

2—

NO

gcca

cagg

aggg

tttaa

acac

agca

gtaa

tgag

acttt

atttc

tgct

ggga

aaac

attg

ccgt

tattg

ccc

53

2572

055

—N

Ogt

gcct

gaga

gaaa

acgg

ccta

atcg

aaaa

cgtc

cgcg

gcat

acat

ccat

tctta

aaac

ttgag

tggc

tgct

tttct

gggt

ggaa

aaga

gcgg

tatc

agac

agg

gtga

gcag

tcgg

ggaa

cgga

tgaa

caaa

gact

tgca

ccgt

ggcc

ctga

tgcc

tttgt

tccg

agttc

tattc

agttg

tact

tgtg

cgttg

ttaca

ggac

ttta

gaat

gcag

ccct

gccc

ccca

accc

ccac

ctcc

cagg

gccg

acct

gtgc

tcct

agga

aggc

aaac

ctc

5434

3454

9M

LE

CN

Otg

gcac

ctct

tgca

tcca

ggca

gtct

tgtg

agat

gggg

gcac

atag

cact

gggg

aaag

caga

actc

cattc

tcac

ctct

atttt

gagc

ttcag

tgct

ttattt

cagt

atga

ggaa

aaac

aaca

acaa

actg

aagt

gcgc

tttcc

gtcc

tttca

aagg

acaa

ctgt

cggg

aagg

gaga

gccg

agttg

cgag

gtag

gagg

ggag

cact

ggca

ggga

gaga

cattc

ttgac

tcct

ctct

tccc

tggt

gtgt

tgtg

atcc

aggg

aatg

aaaa

gaaa

tttga

ccct

ggat

tggt

tctc

tcct

tgga

ctta

agga

atct

tacc

ttttc

cttc

caca

aagt

tctc

ccag

gcaa

ggac

cagc

tgcc

cattc

tgag

ccca

gggc

agcc

tcttc

aacc

atta

ttgg

55

4007

482

—N

Otc

caag

cagg

tcttc

gtag

taga

gaac

gaac

cagc

cctc

gatc

acca

ggtg

aatg

aacc

caca

cact

gcaa

acca

gcac

aggg

acag

tcgc

cgcc

aagt

cccc

aatg

ggac

aacc

gcag

cacg

acct

gaca

acag

ccat

gtgg

tcac

gact

aaga

cccc

tgtg

acag

agaa

gagg

ccag

ccag

tata

tgcc

aggt

gggg

cggt

catta

ggta

caaa

gttg

tc

5627

5139

1C

LC

N3

NO

cccg

agtta

gagc

atgg

attc

agttt

tagt

ctta

aggg

ggaa

gtga

gattg

gaga

ttttta

ttttta

atttt

gggc

agaa

gcag

gttg

actc

tagg

gatc

tcca

gagc

gaga

ggat

ttaac

ttcat

gttg

ctcc

cgtg

tttga

agga

ggac

aata

aaag

tccc

accg

ggca

aaat

tttcg

taac

ctct

gcgg

taga

aaac

gtca

ggta

tct

tttaa

atcg

cgat

agttt

tcgc

tgtg

tcag

gcttt

cttc

ggtg

gagc

tccg

aggg

tagc

tagg

ttcta

ggttt

gaaa

caga

tgca

gaat

ccaa

aggc

agcg

caa

aaaa

cagc

cacc

gattt

tgct

atgt

ctct

ga

5728

7164

5—

NO

ctct

gtgg

ggttc

ggttc

cact

ttgta

gttc

gggt

ttgta

atgt

aaag

aata

atgg

gaaa

ctgg

tcta

atta

tgag

agtta

agag

agta

gagg

cctg

tagt

tg5

836

2957

6PA

RP

16N

Otta

gcca

taat

aggg

cccg

gtac

gattt

ggga

gtga

cattt

ctgt

aaag

aaga

ggaa

aaat

cattt

ttcta

taat

ttgta

aagt

tgtg

aaag

agcc

acta

ccac

agt

tttta

cattg

atta

ttgga

acat

ttc

5925

4593

0IF

T17

2Y

ES

tggt

ggct

acaa

cattg

gcac

cgtc

agcc

atga

gagc

cgtg

tgga

ttggc

tgga

actta

atga

gact

ggac

acaa

gctc

ctct

tcag

6025

6973

4—

NO

ttccc

ttggc

tttgg

acat

gtga

ggga

agta

ggta

tccg

ctgc

ctgg

ggaa

agtc

aaca

ggac

ccct

cctc

cccg

tacc

tcttg

gtat

acaa

agct

gagc

ggtg

61

2832

639

PCD

HG

YE

Stta

ctttg

aagt

ttgcg

gcat

gatg

gtgg

aaag

tgta

aatg

ctaa

aaca

ctga

tgag

taga

atttg

AlO

6231

1334

3N

Ogg

ctga

ttgac

cttg

actg

gcct

catg

tatg

tgtc

tcaa

agttg

gctg

gggc

tgtc

ggct

gaaa

ttcct

tagt

tcta

ctcc

acat

ggcc

tttcc

ccat

ggcc

agc

ccag

gctg

agat

ctga

gattg

aaga

gggt

gaga

acag

aaag

taca

agat

cttc

ttttg

acttg

aaag

ctag

ccca

gaat

cgag

ggaa

ataa

accc

cacc

ttttg

atgg

aagg

agct

tcaa

agaa

tttgt

agtc

atttc

caat

ccac

gaag

agta

ggta

ccca

ctat

ttgttg

aata

aagc

ccta

ttgaa

agct

tttta

gcta

tcca

gatg

caaa

ttact

ggcc

aacc

tttgg

gtag

aatta

taaa

attc

tgcc

caaa

attc

tacc

aaat

tact

ggta

cttg

taaa

attc

tacc

aaat

aact

ggcc

aact

tttgg

gta

gaat

tgta

aaaa

ttaag

ttgta

aata

aagc

ctat

tgcc

taac

agga

acttc

aaag

tcag

agaa

tcct

aaaa

tgat

tgtg

ctac

acag

ggcc

acat

agag

cac

agct

ttgtc

tttttt

tttttg

agat

ggag

tctc

gctc

tgtc

cccc

aggc

tgaa

gtgc

agtg

gcgc

aatc

tttgc

tcaa

ggca

acttc

tact

tccc

aagt

tcaa

gcaa

ttc

ttctg

tttga

gcct

cctg

agta

gtgg

gact

gcag

gcat

gtgc

cact

atgc

ccca

ttatg

tattt

ttagt

agag

atga

gattt

cacc

agat

tggc

cagg

ctgg

tctc

gaac

tcct

gacc

tcaa

atga

tctg

cctg

cctc

ggcc

tccc

aaag

tgttg

ggat

tata

ggca

tgag

ccac

catg

cccg

cccg

cttc

gtct

tttca

ctgg

acta

atga

agat

acag

gtgt

ggaa

tggt

ttcac

agca

tgcc

caac

ctca

tgag

gcttg

ttggg

tcag

agct

tgtg

ccag

atgc

cagt

cttc

tgcc

ttcca

gtct

tata

gttg

ttacg

ctat

agcc

ttctg

cagt

ggat

ggta

acgt

ggcc

aaaa

taag

ccttt

ggttt

tgga

gtat

tcgt

aaaa

tg

63

3875673

—NO

ggga

acta

acgc

cttc

caga

acag

aaat

atgt

ggtc

cgat

gagt

attg

aatg

caac

ttaaa

atct

agttg

gaat

gtga

tgga

taag

aaga

gacc

caaa

gtca

tca

acaa

gcct

tctc

atga

acttt

cagt

catta

acct

tcct

atat

agta

agga

caga

aatg

atga

tttaa

gcca

tctta

ggca

aggc

agtg

ctaa

caat

atgc

tttt

gtaa

agtc

acca

tccg

gtg

64

3959071

—NO

ttctc

taat

tcta

ggcc

tgcc

gtttt

tctc

tgtg

agtg

gacc

tgat

ctcc

ttttg

ctttg

gctc

ccag

agttc

ccta

ttcgc

ttctc

cttg

tccc

ctga

gtcc

tgct

ctcc

-4ct

cctc

tgga

taac

ccct

tcca

gccc

ttcac

ttctc

cctc

ctgt

tattt

gctg

gaat

ggct

aattg

gctg

accc

cccc

accc

agtc

ccca

tggg

agac

cccc

tcc

agca

ccag

aaga

ggca

gact

aaca

ttttc

tttgg

tagc

agaa

tgta

aaat

tgta

aaat

gtga

aaga

tagg

agag

aaac

atca

ttaac

tgttc

tgtta

tttat

taac

atttt

aattt

atag

aatta

taga

ctta

acag

caaa

aattc

aaac

actg

aggg

tcat

cggt

gaaa

ata

65

2864793

—NO

gcct

attg

gcttc

aagt

tgttt

acgc

tttgg

tagg

ttttg

gcttg

ttccc

tcaa

agga

tccc

ttcttc

atgt

cctc

ccat

gatg

ttgca

ggca

aggg

tctc

ttgtta

tat

gtgg

tact

aact

cggg

ccca

cctg

gtca

taat

ttc

66

2976430

—NO

gctc

ctac

agta

acac

tcaa

tcaa

ttcac

ccca

ctcc

agtg

ttcttc

ctgc

aaca

tcac

tgat

ttaga

tggc

ccac

tctg

67

3862771

—NO

ggga

atct

atta

atag

tgga

ggaa

gtat

ttagt

gggt

ggga

68

3192159

BAT2L

NO

tgga

tata

tggc

attg

accc

gcttg

ctttg

atac

gaaa

caaa

aaag

caga

cgac

tcct

tcat

ccca

tctg

ctcc

tacc

gtga

ctgt

gga

69

3062031

—NO

gggt

ttgtc

atgc

tacg

ctgt

gcca

ttcat

gtgt

tttttt

gctc

atgc

tgttc

cttg

tgcc

tgga

aattc

tccc

ccta

attc

ccct

gagc

agtg

gatg

cagt

ggat

accc

tccc

caga

tccc

cccc

aact

tccc

tgag

tgttg

gcta

ccaa

aagc

tctg

agtg

cacc

cagg

gagc

taag

tcct

cctg

ccca

cagg

caat

aatg

gact

gaca

cggg

gtag

actta

aaga

aata

agag

gcac

atca

atca

attg

aaat

gtgt

ggga

cctta

cctg

gact

ctga

atta

70

2505555

PTPN18

YES

gagc

agta

cagg

ttcct

gtac

caca

cggt

ggct

caga

tgttc

tgct

ccac

actc

caga

atgc

71

2361309

—NO

gagc

cgga

cttc

cttg

tccc

acca

g72

3569829

—NO

gtac

tcgc

ctcc

tgca

tgga

gcac

gctc

aggg

gtgg

73

2946327

—NO

ttact

gttg

ctgt

ccgt

aaac

tgga

acct

ctgt

tcac

tcaa

g

7427

5143

2N

Ogg

aact

cctc

agaa

ctta

taat

atgt

tgat

attc

tttga

ttccc

agat

gagg

ggat

gggt

aata

ggat

acat

ggttt

tcca

gact

tgttt

gaaa

atgc

aact

atttt

tgg

gttg

cagg

gaag

gata

tagt

agaa

ctca

tggg

aact

ggtg

tttct

tgga

acat

gcttt

ggaa

atgc

tggg

ttatg

ccct

gtta

actc

ttaca

tcat

tagt

tttta

gccc

aaaa

ggaa

acag

caaa

taat

gtttt

atat

gagc

caca

ttttg

cgttg

atttt

cc

75

3907

608

ZN

F335

YE

Sgg

acgt

ctac

ggaa

gtgg

agca

cctc

cacc

aaga

gcca

agag

gaag

aggg

acca

gagg

agga

ggac

gatg

atga

cattg

taga

cgct

ggag

ccat

tgat

gacc

tgga

76

2316

543

—N

Oat

gaga

cctc

agac

aaag

ccac

cagg

a77

2453

070

Clo

rfll

NO

tgcg

acca

gtac

agac

cctg

tcct

ggct

gaac

aaga

agag

acac

atgc

tcca

cttg

ggag

ccttt

gcca

ccac

gcaa

ctca

gggc

tcaa

gatg

aatg

gga

ggga

gaga

tttga

gtcc

aagc

atac

attta

tattc

agtg

ttgtg

ccat

tgag

ttccc

atgt

ggat

cattc

tgaa

ggtg

atct

ccac

aaga

gggt

gtgt

gtgt

gtgt

gtttg

gtgt

gtgt

gtgg

aggg

gggg

ccgc

tgga

taca

tcac

tgaa

gcta

ttgat

ataa

caca

atga

gtca

ctgt

tcag

aattt

tgct

cttg

ttaga

tgttt

tctta

cat

tggg

taga

gtcc

agcc

78

3119

603

RH

PNl

NO

tcca

gctg

gcag

caag

cacc

gagc

atgc

cctc

ccca

ccca

gagg

acct

ccgg

gcaa

tgcc

tgtc

ccgc

ctca

tgct

ggag

gctg

cctc

gggc

acct

gcc

tgcc

catta

aaga

ctgg

tcag

acct

gt

7939

0880

1ST

AU

lY

ES

cact

gcag

aagg

aacg

ggca

ccaa

caag

aagg

tggc

caag

cgca

atgc

agcc

gaga

acat

gctg

gaga

tcct

tggt

ttcaa

agtc

ccgc

aggc

gcag

ccca

ccaa

accc

gcac

tcaa

gtca

gagg

a

8025

2566

4—

NO

gaag

ctgt

tttaa

tgga

ggcc

gaga

gttg

gaca

atttt

gtgt

tatg

gaga

attc

tggg

aaga

agga

aaga

cccg

gatg

ggac

tgttt

atta

aggc

ttatg

actg

gact

ggag

ata

81

2395

926

CL

STN

YE

Sta

cggg

aaag

aaca

tcaa

tata

agct

gacc

gtca

ctgc

ctat

gact

gtgg

gaag

aaaa

gagc

caca

gaag

atgt

tttgg

tgaa

gatc

agca

ttaag

ccca

c\1

ctgc

a

8225

7114

5A

NA

PCY

ES

ctca

aaag

tgttt

atta

catc

tgac

ctat

gtgg

gcaa

aagt

tcct

gtgc

ttttta

gtag

agtc

ccag

ctcc

a\ 1

8328

3600

6N

Ogg

atgt

acac

tgat

ttggc

ccttt

aaat

gaca

ttata

ccaa

gaag

ttggt

ataa

ggga

gtag

gaga

tgag

aaaa

ctttt

tgaa

aaat

cattt

ggtg

catg

ctaa

ggt

agct

tgta

ggac

atgt

ggttt

taaa

aaat

tcat

ggat

tttga

agaa

ggat

aggg

tgga

agta

aaat

ttagc

tgat

agca

tagg

gatc

atttg

tgat

ttata

taga

aaat

aatta

tattt

ttgag

tgag

aagc

atca

gact

taaa

tttttt

tcttc

tattt

tggt

tatta

ccaa

aagg

aaca

gaga

aact

ctca

gaat

tcttt

gaat

cata

gaat

gtta

gtgc

tgga

aagg

acta

ggaa

gtga

cttg

taca

accc

cttc

atttt

acaa

agga

tcag

agag

aattg

gtta

gtag

agtc

ccaa

atct

gcttt

taga

agta

ata

tggt

gatc

atca

gttta

gattc

actg

tagg

aagg

gcag

ccct

gtta

aagt

ttgtc

agga

gaaa

aagg

gaag

gtat

cact

ttttg

tatg

ttcac

ccag

ttgct

tctg

tagt

tttca

tacc

cctg

ttttc

tcaa

ttttc

ttaga

actg

tcttt

aatg

gccc

agct

ctac

cagg

gcttg

ttgtc

taag

gaca

ttaac

ttgtg

ctcc

cctc

aggg

atgg

gttta

ctac

tagc

tgtc

agaa

agct

attg

ggta

tcct

aatg

tgtta

atag

ctga

aact

cagc

tgta

atttc

tcct

aaat

acttc

agca

ttttg

cattc

tgta

cattg

tgg

tgct

ttttc

cacc

ttgta

ttgttg

taac

tgta

agct

ccta

gggg

gcag

caat

ttggt

ctta

ggcg

tgta

ccct

gttta

gtgc

ctgg

caat

gcca

tgttt

atat

caag

gtc

ttaat

atta

ctttt

gagt

tattt

ctcc

cact

cttc

atgg

aagt

gatg

ctcc

agcc

ttgct

aaaa

cact

gagg

gtcc

tccc

gata

agcc

aggc

attg

tgat

tcct

tggc

ttcaa

gtgc

cttc

tgtc

ttccc

cgaa

ggtc

cact

gaga

tcta

caat

cccc

cctt

8425

1777

3N

Ota

gcgg

agaa

tgac

ctac

ctac

ttgat

taat

gatg

tctg

catg

ggct

tact

aaga

gggt

gtgg

ggaa

tggt

ggca

gggg

taac

tatc

atcg

agaa

tata

ggg

caat

gggt

atat

tcta

acttt

gcat

aact

ttgct

agat

tata

tata

tcttt

actc

acaa

taag

caaa

gttg

aaca

actta

aaat

tgat

tccc

tgttt

tctg

ttttc

acta

tcca

acta

ggat

gaac

tctta

agttc

atac

atat

acttt

aaaa

tggg

aaca

aaca

tagc

ctgt

catg

tcttt

attta

ggct

aagt

gcat

atgt

atgt

ataa

gtaa

tgtg

tat

atcc

ttcac

ttatta

atag

tgcc

ttcat

gaat

tcaa

agac

ccttg

tcac

atgg

tgct

cagg

aaaa

aaaa

agtg

ccaa

tattc

tttttt

tttttt

tctc

taag

aagt

act

agttt

aggt

aagt

gaaa

ttcaa

tagc

atat

cagt

gcttt

acct

tagt

cact

ttttg

tgttt

tgat

cacc

ctta

gtca

tcac

tgga

gaga

agag

tttga

attc

atttg

tgg

ttttg

cttta

gtgg

caaa

cctc

ctta

cagg

gatg

agttg

ccct

ccat

tctc

cttg

ccat

atttg

gtta

atct

aggc

catg

acct

ttgag

ggga

aaag

gcac

agat

tgc

aact

tttct

ttcct

gcttt

tgtg

aatc

aggc

catg

ttcac

gcag

ggtc

cttg

aagg

tgac

ttgag

tgag

gaag

ctat

atac

cgat

gact

tacc

aattt

ttggt

ctt

ataa

cattc

tctc

tcttt

tttttt

tttttt

ttttg

tagc

atat

ggct

tcct

ctac

tgta

tgttg

gcat

ttgcc

acttt

tggg

gattt

gact

cctg

cagg

tattt

tttttt

ttttc

ttttg

gggg

agtg

tgac

ggca

gtgg

atat

agtc

ttaga

tgat

gtttt

taat

agttc

aagt

ccat

tagt

gtct

tact

ctag

agaa

aacg

aaag

actc

actg

tgtg

agttt

tct

tgcc

ctct

ggttt

tcag

aattc

tgtg

tagt

ttctc

aaca

t

8530

6495

7—

NO

aaat

ccac

agcc

acat

ctttg

aatg

8632

3918

1K

IAA

12Y

ES

tcat

tctc

accg

caga

gtca

aaat

ggcc

gagc

accc

cctc

17

8736

2901

7C

SNK

lN

Otc

acca

tcta

taag

gtct

caga

gcag

agga

ttattc

atgg

taat

aagt

gggg

gtgt

ggtg

cagc

cattc

cagt

aaca

ccca

-4 4-G

l

88

3709

453

NO

ggtg

ggac

ttaca

ggtc

tcgc

tata

gcac

caga

taaa

atcc

atac

taca

ccct

atca

ttacc

tggg

aatg

aggg

taca

ggag

aaaa

cagt

aaag

cctc

aaa

agga

ggaa

attc

gtaa

agag

tcct

taaa

aacc

ttaaa

tgat

ttcca

aaaa

ttatta

gggg

acgt

taat

tgga

taag

acct

acttt

agga

attc

ccac

ctaa

gcaa

tgtc

taaa

ctgt

ttgct

ttgct

gaga

tggg

atcc

aaat

tcat

gtag

caaa

agaa

ctct

gatg

cctg

ctgc

agct

gaag

agtta

caaa

tgat

tgag

gaaa

aaat

tcaa

agtg

ctca

agtc

cgta

gaag

agat

ccta

gtgt

tcca

ttaca

gctc

ttagt

gttc

ccta

ctct

ccat

tctc

ctat

agga

gtga

ttgttc

aaaa

tgttg

actta

gtta

aattg

tcct

tttta

acgc

acag

tacg

acta

gaac

tttct

caat

ttattt

agat

caaa

tagc

tattc

ttata

ggcc

aaat

acaa

ctga

gaat

agtc

agac

tcat

tggc

acc

gatc

gaga

taaa

aatg

tagt

tcct

ttaaa

caaa

gcac

aggt

tcga

caag

ccttt

atta

attc

gtca

gaat

ggca

gtca

aatc

tggc

tgat

tttgt

tggc

agta

tag

atat

tcat

tacc

ctaa

aact

aaaa

tgttt

cagt

tcct

aaaa

attg

acta

ccta

aattt

tacc

caaa

ataa

ctag

ttcca

ttcct

ttgga

ggga

gccg

taac

tatc

ttta

8927

3201

2FA

M47

YE

Scc

ttata

agcc

aaag

tggg

tgaa

gatg

aggt

atgg

agca

tggt

atttg

aacc

ccaa

gttg

tgga

aaaa

gcaa

agag

taga

cgag

cctc

tggt

tgac

cctg

aE

ggtc

tcac

ata

9027

8758

8__

_N

Ogg

ttgct

gccc

ttgag

cattt

tgcc

91

3630

110

___

YE

Sat

ggag

cacc

tgttc

gtgt

acct

cc92

3738

711

—N

Ogt

agct

aaac

atat

gcgt

gggg

ataa

aaat

cggg

tgga

caag

gcca

gata

catg

aaga

catg

ctcc

actc

tcat

ctgt

gaa

93

3675

240

NO

cccg

gact

gatg

tgat

ttcttt

gaca

atta

caaa

aaac

aaaa

aaca

aaca

aaca

aaaa

aacg

caaa

gcaa

tagc

aggg

aaag

gaca

gtttg

agaa

gacc

tgc

aagg

cctg

ccag

gcgg

ctcg

cttg

tgca

gaca

caac

cggg

acgg

ctttg

aggg

gacg

tgca

cacc

caag

9434

5892

2C

TD

SPY

ES

ggga

cctg

agaa

agac

cctc

atcc

tgg

29

526

9433

7__

_N

Oga

ggaa

gact

tgtg

cgcc

cggc

ccac

acga

acca

taga

gccg

atct

ccgg

g96

2990

414

—N

Occ

ctcc

acac

gtgt

tcag

ttaaa

gtgt

gagg

aata

ccct

cccc

agac

aaac

atca

caga

tttcc

gaaa

tcaa

acac

gctc

cagc

aagt

gttc

tgca

cacc

ccac

tg

9731

9032

8—

NO

cttc

tcag

ttggg

tcaa

gtcc

attg

acct

ttctg

ttaca

gcttg

agttt

tgtg

tctta

cgta

gaaa

aggt

gccc

ctgc

tctc

acttt

ctgc

acag

ctat

cagg

tcca

gct

cata

gcag

ttcttc

ta

98

3745

435

MY

H3

YE

Sct

gaga

ttgca

ggat

ctgg

tgga

taaa

ctgc

aagt

gaaa

gtca

agtc

ctac

aaga

ggca

ggcg

ga99

3110

076

LO

ClO

ON

Ogt

aaaa

gcgc

ggca

ccga

cacc

agct

gtgt

gcag

cagt

ggcg

gcgg

cggc

cgaa

ggag

aaat

agaa

cagc

gcag

gcaa

aaga

agaa

aggc

gcgg

1341

28gc

tgg

100

3471

539

...N

Oca

cggg

tccg

ctag

cttta

agta

caac

agga

tttcc

gtgt

tcaa

aaga

ctat

acta

agtg

ctta

atca

aatc

ccgt

caca

ctaa

agcc

aaat

ttagt

tctc

tagg

aatc

ggag

tctg

cgta

ta

101

3918

710

SON

YE

Sca

gagc

agcc

tgta

gacg

tacc

atcg

gaga

ttgca

gattc

atcc

atga

caag

accg

cagg

agttg

ccgg

agct

gcct

aaga

ccac

agcg

ttgga

gctg

cag

gagt

cgtc

ggtg

gcct

cagc

gatg

gagt

tgcc

gggg

ccac

ctgc

gacc

tcca

tgcc

ggag

ttgca

gggg

cccc

ctgt

gact

ccag

tgct

ggag

ttac

ctgg

gccc

tctg

ctac

cccg

gtgc

caga

gttg

ccag

ggcc

ccttt

ctac

ccca

gtgc

ctga

gttg

ccag

ggcc

ccct

gcga

cagc

agtg

cctg

agttg

cca

Ul

gggc

cctc

tgtg

acac

cagt

gcca

cagt

tgtc

gcag

gaat

tgcc

aggg

cttc

cagc

acca

tcca

tggg

gttg

gagc

cacc

acag

gagg

tacc

agag

cca

cctg

tgat

ggca

cagg

agttg

ccag

ggct

gcct

ttggt

gaca

gcag

cagt

agag

ttgcc

agag

cagc

ctgc

ggta

acag

tagc

aatg

gagt

tgac

cgaa

caa

cctg

tgac

gacg

acag

agttg

gagc

agcc

tgtg

ggga

tgac

aacg

gtgg

aaca

tcct

gggc

atcc

tgag

gtga

caac

ggca

acag

ggttg

ctgg

ggca

gcct

gagg

caac

gatg

gtgc

tgga

gttg

ccag

gaca

gcca

gtgg

caac

gaca

gcgc

tgga

gttg

ccgg

ggca

gcct

tcgg

tgac

tggg

gtgc

cag

agttg

ccag

ggct

gcct

tcgg

caac

tagg

gcac

tgga

gttg

tcgg

ggca

gcct

gtgg

caac

tggg

gcac

taga

gttg

cctg

ggcc

gctc

atgg

cagc

tggg

gcac

tgga

gttc

tcgg

ggca

gtct

gggg

cagc

tgga

gcac

tgga

gcttt

tggg

gcag

cctc

tggc

aaca

gggg

tgct

ggag

ttgcc

aggg

cagc

ctgg

ggcg

ccag

agttg

cctg

ggca

gcct

gtgg

caac

tgtg

gcgc

tgga

gatc

tctg

ttcag

tctg

tggt

gaca

acat

c

102

2792

431

TM

EM

lY

ES

tcct

tgga

tatc

accc

agag

tattg

aaga

cgac

ccac

ttctg

gatg

ccca

gcttc

tccc

acac

cact

catta

caag

ctca

cttta

gacc

ccga

ttcca

tcct

ctt

92cc

taca

gtca

tcat

agtg

aatc

ttc

103

3828

963

DPY

19Y

ES

gaag

tgga

gcga

gaaa

tctc

attc

agaa

caga

gtgt

ggcc

tgta

ttact

ccta

ctac

aagc

agat

gctg

cagg

ctcc

aacc

ctcg

tgca

aL

310

438

7492

7C

DS2

YE

Sgt

tcat

tgtc

ccca

tatc

ttgtg

tgat

ctgt

aatg

acat

catg

gcct

atat

gtttg

gcttt

ttcttt

ggtc

ggac

ccca

ctca

tc10

530

1246

8A

KA

P9Y

ES

ctgg

ggtc

aggg

aattt

atct

taca

caca

gtca

ggga

tttga

cata

gcat

caga

aggc

cgag

gag

106

3541

309

PLE

KH

YE

Sga

tgtc

atcc

ggaa

acct

caag

gcca

agtg

gatc

tgaa

ctcc

cgct

gcca

aattg

ttcga

gggg

aggg

ttcac

agac

gtttc

agH

l

107

3543

492

PSE

Nl

YE

Sgc

aagt

gaca

acag

ccttt

gcgg

tcct

taga

cagc

ttggc

ctgg

ag

108

3878

896

—N

Oaa

cgtg

ctca

ggga

gaat

cagc

tggt

ttct

109

2669

445

—N

Oat

ggct

aaaa

ctcc

aata

gaca

gcat

gtag

tgct

tggg

tgac

agac

tttgg

gaca

atca

cagc

cact

acaa

agtg

aaag

ggga

gaat

ccag

aaag

taca

gag

ccag

aaag

ggag

agcc

ccaa

attc

tatg

taaa

aact

gccc

aaat

ctttg

gctg

acca

ctga

acta

tgca

tgca

tggg

gcag

acgc

taag

caac

ctag

ctaa

ggat

aaaa

taac

taag

ccga

gaat

tgag

gtag

tgcc

tc

110

3953

763

PI4K

AY

ES

gagc

aacc

tgga

cata

actg

tcgg

ctct

cggc

aaca

agcc

accc

aagg

ctgg

atca

acac

atac

cccc

tgtc

cagc

ggca

tgtc

cacc

atct

111

3529

048

NO

gccc

agta

cctc

tcca

aggg

ttgta

tatc

cggt

gggg

gtgg

aggg

atcg

gcag

aggt

ggtg

tctc

agcc

ctttc

gttc

aagg

agcg

ggttg

atgg

tggt

ggtg

tagg

aattg

ctgg

gtct

tgga

aact

aggg

gcac

cagg

tact

gcgt

tgtc

ccga

aacc

acttt

agttg

ccca

tgct

tcaa

ggca

tagc

gtgt

gtca

ccaa

acca

ctga

atga

tctc

aggc

cgag

gtaa

acca

gtga

tctg

ttcta

acttt

tggt

aatc

ctca

cgcc

gtgc

ccac

tggc

actg

taaa

aaaa

agga

tttaa

ggat

agc

cagc

tgct

ctttg

gtttt

gcgc

ttggt

ctttc

gctg

gcgt

tgca

tatc

tggg

gaaa

ggta

ctct

gtgg

ggcc

aact

ctac

ctgg

tact

ga

112

3691

111

—N

Ottg

acgt

ggct

tatc

aacc

tttgt

ctct

tacg

tgct

ctttg

ttccg

gcca

tcgt

cttg

tttaa

caaa

113

3845

902

TIM

Ml

NO

gggt

ccgc

atgt

acgt

actg

cctg

cccg

gggc

ttagg

aggg

tggc

accg

gtgc

tggg

acac

acgg

gact

gtgt

cctc

gcca

cccc

ccgc

cctg

cccc

ct3

gcca

gcca

gtgc

agct

tgga

tctc

gggg

gtgt

gggg

ccct

gtgc

cttc

ctga

agtg

ctgg

cagc

ccag

tggc

acct

ccttc

aggc

ctttg

gggt

attc

ccct

agtg

tgcc

caag

tcag

cctc

atat

tctg

ggcg

gaca

gcttg

tctg

gact

tcgg

agttg

gggg

tggt

caga

cacc

acag

gagc

tgtc

acct

cctg

cgga

tgg

gcaa

ataa

att

114

4009

521

PHF8

YE

Sga

ccct

gcttt

gaaa

tctc

gacc

caag

aaaa

agaa

gaat

tcag

atga

tgct

ccat

ggag

tcc

115

3817

782

—N

Oca

tgcc

cggc

ccag

taat

tagg

tttttt

tttaa

aaag

cccc

aaac

ctta

atttt

atttg

cccc

tcat

ttcac

ggag

ctcc

cagc

gtag

tggg

gaga

agct

ggcc

cag

agaa

cccc

acgt

cctg

caca

gtga

gggc

cagc

ccttg

ggga

cccc

atgt

cctg

cacg

gcgg

gggc

cagg

ccct

gggg

ccac

gtgt

gttc

cccc

ccc

accc

ctat

tttct

gccg

cgtg

ctcg

ttctg

ctgc

acgt

ggct

gtca

cttg

aatg

ggaa

tttaa

aaat

ataa

ctta

atgc

acac

tgac

ttccc

ttgat

tggt

gcaa

ttaat

tattt

gaaa

agaa

aaat

atca

cagt

gttc

ttaag

gact

ggca

tttttc

caag

ctgt

gtca

gtttt

gattg

atgt

ctga

cgcc

gtgg

ctgg

cttc

tgaa

agcc

tca

ccag

ttctg

atgg

ctta

ttggc

gact

tcag

tgta

tcca

gcaa

tctc

tgct

catc

tttct

gggg

gaat

atat

aatg

atca

gcag

gcct

gaga

actc

ctac

aaat

caga

gata

agaa

aaca

aatg

gccc

gatg

aattc

ggcg

tgag

gggc

ttgag

caga

cgcg

ttacg

aagg

agct

gcag

gaac

gaaa

gcca

tggt

tcag

tgcc

cag

catc

ggta

gaag

tcag

aggc

agcc

agct

ggga

gaca

ccgc

cagc

ccca

ggac

ggcc

acgt

caga

acac

cgcc

acca

gatg

ccag

tgag

gagg

gcg

cagc

tgca

cgct

gctc

ccag

ccgg

ggtg

gatg

cagg

gcgg

tgcc

atgg

ccat

ggaa

aacc

gttc

ggca

ttttc

ttgga

aacg

gaag

catg

tacc

ctgt

gccc

cagc

gatg

ccac

tctg

tgca

tattt

actc

agga

gaaa

tgaa

aaca

tatg

tctc

caga

aaga

ttggt

acat

aagt

gttc

ttagc

agttt

tcttc

acga

gagc

ccca

aact

ggaa

acag

cccg

cacg

tcca

tcaa

cagg

agga

taga

taaa

taaa

taac

cata

gatc

cacg

cgca

accg

agta

ctgt

ttaga

aatg

aaaa

gga

gcg

116

3948

736

—N

Ocg

ttgat

ccca

cctc

cttg

atct

ggttt

ctaa

gacc

tcat

acaa

actg

ggcc

cgtta

gtct

ttgct

ccct

gata

ctat

ctga

tacc

atct

ggtc

tcac

117

3104

724

ZB

TB

lON

Oct

ggtc

ggac

ggaa

acgc

tccg

ccgg

cttta

ttgtc

gcttc

gtta

tgtg

gcgg

agcc

gagc

agttt

agcg

tgcc

tctc

accc

tcag

cgcc

tgcg

aagc

cgg

c11

833

6456

5PL

EK

HN

Oac

tggc

ctgt

gcta

ctta

ttacc

gggc

ttgta

atag

cggt

tcttg

tctc

cata

gcct

gttg

agtg

ttccc

agat

gtga

ctca

ccttt

ctgc

tgcc

ctct

tcat

gcag

A7

gcct

actg

a

119

3540

221

NO

atga

ggcc

ggaa

agat

ggcg

aattt

gcag

ggct

gg12

034

5807

5N

Occ

aaat

tttag

ttgtg

agga

aaca

gaca

tacc

aagt

attc

ttttta

gcaa

tgag

catta

gttc

tgttt

ttctta

acag

tgag

gcaa

acta

tgta

tattt

acat

tttgt

agaa

tattt

cctc

caaa

attg

gtttc

tgca

tact

ttttg

tttttg

ctat

cact

gtttg

ggct

taga

gtag

tatc

cttg

aggc

tcgt

ctca

tcttt

tttat

ttgttt

tgttt

ttttg

tttgt

ttggt

tttgt

tcttt

gaga

ctgc

tgca

gtac

aatg

gagc

gatc

ccgg

c

121

3773

290

NO

cagg

ctca

tcat

tcct

tgttg

gattt

cttc

ctgg

actta

tttaa

aagt

tgtta

tagc

tatta

tgaa

tgag

ctttt

ttaaa

aattg

taat

tcct

aact

atat

tact

ggtg

tag

aaga

aaac

taca

gagc

tggt

atcc

agct

acttt

attg

atttc

ttact

gtttc

tattg

gcttt

tattt

ttcat

tagt

agag

gttg

agaa

tttca

gtat

ttcat

tccc

agat

ccat

atct

cattt

ctttc

tcttg

ttttc

tttgc

gttg

ctgg

agcc

tcca

aaac

agtc

tggg

gtaa

ctgc

tatg

ctag

cagg

cctc

ctca

tc

122

2835

195

FLJ4

160

NO

ttatc

ggtg

tagc

agag

aggt

tccc

aaga

ctct

tgac

tggt

cctg

ggag

tggg

tgtg

acca

agtc

atag

ttctg

gaat

gtgt

gtag

gcaa

attc

agag

gctg

tt3

ccag

ggaa

gagg

ggat

tttga

tact

gtgt

tagg

tggg

gtgt

gtga

ggct

gttg

gcag

cagg

tgaa

cagc

tact

gctg

tgttc

tcag

gact

aggg

aaca

aag

gggt

atgc

aaat

cata

gagg

aaac

tctg

ggaa

ggcg

gtga

taag

gcct

ggtg

ggtg

ggga

ggtta

ggga

atgg

cttg

ctttc

ctgt

ttctg

gtta

gaag

ggga

gcca

gggg

gaac

cccc

agtg

gtttc

aggt

ggcc

cctg

aggt

cctg

gagg

cagc

cgtg

gatg

tgat

gcaa

ttggc

tgtg

ggac

ctta

gatg

tagg

aca

caac

ttcag

tgttc

ccat

ccag

aaag

acct

cact

caca

gggt

tgtg

ctga

gaat

gacg

tggg

gcta

agca

tgca

gagc

tccc

tgta

aact

gtga

agtg

tgat

acaa

atgt

aaat

gaca

gcag

tgat

ctcg

gggt

ggcc

cccg

gcat

gctg

ccct

cccc

cacg

ccca

tgcc

tgtg

gcag

caaa

ccttg

ttcat

cagt

atag

cttt

ctttc

ctgt

aacc

cagg

atct

acct

tggg

gggc

ttctc

aata

ctgc

attc

tatg

tagc

cagc

ctct

ttaac

ttggt

aagt

gagc

cacc

ccat

tcta

gaac

ctgg

aaat

tgga

gccc

ctca

aaaa

cagt

tcct

gttc

aagg

agga

ctga

cctg

ctgg

ggca

atgt

tggg

tgca

gtgc

agtc

cctg

cttg

gggt

ggtc

atgt

ctag

gctg

ttg

ctct

gggc

aaag

ataa

gttg

caag

attc

acag

aaat

ggga

aaat

gtga

ccaa

gtgt

gatc

ttaac

aact

gaca

aagt

ttgta

acca

accc

aagt

taga

atg

tgtg

tcaa

acag

gagg

tagt

ttaga

tatg

cttc

caag

aaca

tgtc

tgtg

ttata

acca

tagt

gcct

aagc

agtg

agct

ctgg

tttttg

aagg

gcttt

taag

aa

123

2988

321

FOX

Kl

NO

aggc

tctc

cggg

caaa

tcag

aagg

ccac

gaga

gaga

gagg

agcg

ggga

gagt

ggtg

agga

ggat

tcgt

ctct

gact

gatg

aacc

tcgc

cgtg

cctg

tctg

tcac

atcc

aagt

ctgt

gcca

gctg

ctgg

gagg

tcag

actc

ctgc

cctg

agaa

124

3632

941

UB

L7

NO

ccca

gcaa

gttg

caga

ggct

actg

ccct

tggg

aggc

actc

atga

aggt

gcct

ccat

ctct

ccct

tccc

caat

atac

ctga

tggt

caac

tctc

125

3855

574

—N

Ogg

cagc

aggg

gtca

gattt

tcct

catg

gcct

ctcc

agca

ggcc

agcc

cggg

tttct

cctg

gtgg

ctgg

gagc

cagg

agag

cggc

tccc

atgc

agag

tgct

ggttt

caca

tttgt

gggt

ggcc

catc

cgttg

aggc

cagt

cacg

tggc

cagg

ccca

ggac

caga

tggg

agag

gacc

gcac

aagt

gcag

cgtg

agct

gtgg

gagg

tgtg

gctg

acca

cgct

taga

gagt

gtgg

tgcc

agga

aaga

tctg

atgt

gtca

ccat

tcta

tatc

tgtg

atgg

gcag

acgc

aggc

aggt

caaa

gggg

ccct

gggg

actta

ccga

gccc

ctgc

ctat

tggc

cagg

cact

gtga

ttgtc

ctcg

gtgc

catg

tgcc

atgg

aagc

cctc

tcag

aggt

cgag

ggga

ggca

ggtg

gaga

caga

gcct

ctgt

aggc

ctttc

aagc

tgta

gccc

caga

gccc

agag

gcag

ccga

attc

atgt

gtgc

agtc

agag

agca

ctta

gtgg

gcac

tgta

gtca

atca

gtga

gcgc

ttact

ggac

acca

cagg

cagc

aagc

attta

ctga

gtac

ctct

ggca

gttg

atgc

atac

ttcct

gagt

acct

gttc

atag

cagg

ctta

gct

ctgg

atgt

gggg

tggt

gagg

aatc

ccac

aggc

tgag

gggt

ggcc

tggg

agct

ttcca

gggg

gcct

gaag

cagg

aggg

gctg

cctg

agtg

ggtc

agca

gccc

agcc

cagt

gccc

tacg

cagc

cctg

ccca

cacc

ccca

accc

agcc

tctg

tctc

ccca

gtcc

catc

cccc

acac

cctg

gtcc

ctcc

tact

ttgtg

cctc

gag

gaca

ctgc

cccg

ctgc

cctc

ctca

cttc

ccag

cgtc

tgct

gtcc

cctc

cgct

gctg

ctgc

ccgg

cagg

attg

ctct

gtgt

ctca

tcca

cgttt

gtcc

ctgc

aga

gttc

ctcg

cctc

tccc

tgga

accg

ccag

cctc

atgc

cgca

tctc

agag

gcttt

tttttt

ctct

ctttt

tttttt

ttttg

agat

ggag

tctc

actc

tgtc

accc

aggc

tag

agtg

c

126

2648

215

—N

Ottt

cgca

gttg

ccaa

aaat

ggtg

ccgt

aagg

ctttc

ctgg

aatta

agta

gtca

gttg

gtat

ttggt

tagc

agat

gcttt

gtaa

aacc

taat

atat

tccc

acta

tattt

cct

ttaaa

aatc

aagg

gggg

gtta

acac

cttta

gattg

tcat

gtttt

attg

agaa

aaat

ccac

ttctc

tgaa

actc

ccta

ttact

g12

727

1400

9—

NO

atct

gagg

ccaa

ggat

aaat

tcat

caac

tggg

tagc

cacc

acta

taga

agaa

gcca

acca

caat

caat

gtcg

gcta

tgcg

tcca

gctg

ccag

aggc

cgcc

agga

atga

gcta

ccttg

aaga

atcg

tccg

tgac

aaca

tttct

gaat

ggct

atgt

cact

atca

atgg

ggcc

acaa

caac

aaca

cttg

caat

ccaa

cctg

aact

tO

Occ

tatg

acca

aacc

aagc

aatc

tattt

atgc

ccaa

gtca

agtg

aaag

gtga

actc

cacc

ttcac

catg

catc

aaaa

gcct

tggt

atcc

tgcc

caat

atgc

ctgg

aacg

gtat

atat

tggg

aacc

tgct

gtgc

tggt

ggcc

ggat

tcca

tata

gctc

c

128

3342

827

NO

gagc

aggc

agttg

gcaa

accg

gaaa

g12

934

9423

5L

MO

7Y

ES

ggaa

agaa

gccg

cagg

atca

gcttg

ttattg

agag

a13

038

1634

4SF

3A2

YE

Sgg

agct

acct

ggca

cata

cgca

gggg

aaga

agc

131

2340

361

DN

AJC

NO

cggc

ggct

tcgc

ctcg

cccg

gcga

agct

tctc

tccg

gtgg

ccgc

tcct

tcttt

tccc

tcct

ctttg

cgtc

atgt

cggg

cact

taat

ttttt

613

235

5728

6H

OM

EZ

YE

Sag

agca

gctg

gcta

tcct

taaa

tcct

tttttt

taca

gtgc

cagt

gggc

acgg

cgtg

agga

ttacc

aaaa

gtta

gaac

agat

cact

ggttt

acct

cggc

ctga

gatc

attc

agtg

gtttg

gtga

caca

cgct

atgc

cttg

aagc

atgg

gcaa

ctaa

agtg

gtttc

ggga

caac

gcag

tacc

tg

133

3911

399

NO

atttt

cctg

cattc

acga

tggc

ctcc

134

2612

381

EA

FlY

ES

cagc

agta

aaat

ccag

gccc

gaat

ggaa

cagc

agcc

cact

cgtc

ctcc

acag

acgt

caca

gcca

ccac

cacc

tcca

ccac

ctat

gcca

ttcag

agct

cca

acga

agcc

tcca

gttg

gacc

caaa

acttc

tccc

ttgaa

agat

aacc

cctc

acct

gaac

ctca

gttg

gatg

acat

caaa

135

3354

739

...N

Ottt

gaga

ggtta

tttgt

ccat

ggga

tgct

cgtg

ttaaa

acaa

aaa

136

3434

425

RN

FlO

YE

Sta

atcg

caaa

cgtg

aact

ttcct

accc

caaa

aatg

aaag

tttta

acaa

ccag

tccc

gtcg

ctcc

agttc

acag

aaaa

gcaa

gact

tttaa

caag

atgc

ctcc

tcaa

aggg

gcgg

cggc

agca

gcaa

actc

tttag

ctct

tc

137

3734620

KCTD2

YE

Sag

gaag

cgga

gtttt

acaa

catc

gcgt

ccct

tgtg

cggc

tggt

taag

gaaa

ggat

acg

138

3802333

LOC728

NO

ttcag

ctac

gttg

tccc

agca

cttc

actg

gtta

acct

tttat

gtcc

acca

tttgt

ggat

ttcac

agct

acttg

tcaa

tggt

gaat

attg

atca

tcat

catta

tcta

ctga

606

gctg

ctac

cata

tccc

agct

actc

cttg

catg

ttgttc

atta

ttttc

tcaa

cact

cagc

atat

ttgca

atat

gtta

tgta

atat

caca

gaca

agga

aact

gaac

gca

gaaa

tgttt

tattt

cttg

ccaa

acat

caca

tgag

gatg

aaca

atga

aacc

gattt

gaaa

ccag

gattg

tctg

attc

caac

atct

ctgg

gtcc

tttttc

actc

tgat

atg

139

2896736

NO

agga

tcta

gctc

tcttg

ctca

agct

ggag

tgca

gtgg

tatg

atca

aaac

tcac

taca

gcct

gcaa

ctag

tgat

cctc

ctgc

ctca

gcta

tagc

taaa

acta

tag

140

3053930

NO

ttggc

acac

taac

tcca

cttc

taga

catc

tatc

ctaa

gata

ataa

tcaa

cata

taaa

aatg

caca

taca

aata

ttgac

tata

agaa

taaa

aaaa

tttca

gcat

ttaa

gctg

taca

ggtg

aatg

tttaa

atta

tggt

acac

ccat

ttgtg

ttattt

atttt

aaaa

aattt

ttttg

aagt

ataa

ctat

gtag

aaaa

ctgt

ccta

gcat

aatg

ttaag

cat

cgttc

ccaa

tgtg

ttt

141

3459700

NO

ctaa

ggtg

agac

aggt

ctgt

gaat

ccgg

ggtc

tctg

tcac

ttggg

gaaa

aaaa

acgg

gcag

aaaa

gctc

tgaa

gtttg

aaac

acat

aagg

aaaa

tctg

cta

tctg

tacc

ccca

ccct

ccca

aaat

atag

ttgac

gccc

ccgc

gtga

tgaa

gagt

ttatg

gggg

tgga

ggct

tgga

ggag

atgt

cact

gcgc

ctgg

gagc

ttgt

gtcc

gattc

cggg

aggt

ggcc

gtgt

ccga

gtgc

gtgg

ttgta

cattt

ccga

aggt

ctca

gtttc

tctc

acttt

cagc

ccgc

ga

142

3223562

MEGF9

YE

Sgt

ctgc

cagt

tgcg

atgc

cctc

acag

143

3888086

ARFGE

YE

Sgg

aaag

gcct

tgac

atgg

caag

acgg

tgta

gtgt

gacg

tcca

tgga

gtcc

acag

tgtc

ctcg

ggga

ccca

gaca

actg

ttcag

gatg

accc

tgag

caat

ttF2

gagg

tcat

caa

144

3378887

TMEMl

YE

Sgg

attc

cagc

cgaa

cttc

catc

cgca

g34

145

3280240

—N

Oac

ctttc

cctg

aggt

tgga

tagg

cact

gctc

ccct

tctc

tgtg

cccc

tggc

tccc

acat

ctaa

tgttc

tcct

ggca

ctta

cgac

actc

tcat

tcaa

atttt

ctag

ccat

gcac

ctta

agcc

c

146

3379391

—N

Ottt

tgta

catg

cact

tgca

gtat

tgag

gtta

atca

147

2351210

FAM40

YE

Sgc

agca

ccca

cctc

aaaa

gcca

aaac

agac

tcaa

tcaa

catc

ctag

cgga

cgtc

ttgcc

tgag

gaga

tA

148

3758440

—N

Ogt

ttcac

tatc

gaga

gtcg

gact

gcttt

tgga

tttac

gtgg

ctttg

tggg

atgc

ggta

tgaa

gatc

gttg

cattc

aagt

ttacc

gcct

ctac

ttcac

tgca

gaat

ctga

ctgc

cgtc

agat

ctgt

atga

c

149

2617

213

ITG

A9

YE

Sta

ttggg

ctgg

aacc

atca

aagt

gctg

aacc

ttacg

gaca

acac

ctat

ttaaa

actg

aacg

acga

agtg

atca

tgaa

cagg

cggt

acac

c15

036

7783

5C

RE

BB

YE

Saa

ccag

agga

gtta

cgcc

aggc

cctc

atgc

caac

ccta

gaag

cact

gtat

cgac

agga

ccca

gagt

catta

ccttt

ccgg

cagc

ctgt

agat

ccP

151

2332

491

—N

Oat

ccttc

taag

aggc

gcaa

gttg

gctg

ccttt

ccag

aatc

ctct

gattt

tcgt

tgat

ccaa

gggg

ctgg

aact

gagc

ttcct

ttttc

atgc

caag

tagg

gtcc

aaa

caac

agag

aaac

ataa

agct

cttc

ctttc

tccc

caac

ctca

ccag

ccct

tacc

atgg

ctgg

cttc

ccag

tgat

tcat

tcaa

ggca

aca

152

2932

426

RB

M16

YE

Stg

gggt

ccgg

ccat

ctaa

tgttt

ccag

tagt

tctg

ggat

tattg

cagc

ccaa

ccac

caaa

tattc

taaa

taac

tctg

gaat

attg

ggaa

taca

gcca

ccca

gtgt

gtca

aata

gttc

tgga

ctttt

ggga

gtgc

tacc

ccca

aata

tacc

taac

aattc

tgga

cttg

tagg

agta

cagc

cacc

aaat

gttc

caaa

tact

cctg

gact

tct

ggga

acac

agcc

acca

gctg

gacc

tcaa

aact

tacc

ccct

ttaag

tatc

ccta

atca

aagg

atgc

ccac

aatg

ccaa

tgtta

gaca

ttcgt

ccgg

gact

aat

acca

cagg

cacc

tggg

ccaa

gattc

ccttt

aata

cagc

ctgg

aattc

cacc

ccaa

cggg

gaat

ccca

cccc

catc

ggta

cttg

attc

agct

cttc

atcc

acc

accc

cgtg

gacc

ttttc

ctcc

agga

gata

ttttta

gtca

acca

gaaa

gacc

tttttt

agct

cctg

gaag

acaa

agcg

taga

caat

gtta

ctaa

ccca

gaaa

aaa

ggat

acca

cttg

ggaa

tgat

aaca

ttcaa

cagg

aagg

agat

agag

atta

ccgg

tttcc

tcct

atag

aaac

cagg

gaaa

gcat

tagt

agac

ctcc

ccct

gtgg

atgt

taga

gatg

tggt

tggg

cggc

ctat

agat

ccaa

gaga

aggt

cctg

gacg

gcct

ccac

taga

tggt

aggg

atca

ttttg

gaag

acct

cctg

taga

tata

aga

gaga

atct

tgtg

aggc

cagg

tata

gatc

atct

tggt

cgaa

gaga

ccac

tttgg

cttta

atcc

agag

aagc

cctg

gggg

cata

gagg

agat

tttga

tgag

aga

gagc

atcg

ggttc

tacc

ggtc

tatg

gtgg

tcca

aaa

153

3273

785

AD

AR

BYYE

ESS

taaa

gtaa

gcat

attg

tcaa

ccttc

ctcg

ctcc

tttca

agca

cctg

agtc

ctgg

catc

acaa

acac

ggag

gatg

acga

cacc

ct2

154

4015

409

TSP

AN

YE

Stg

agaa

ggct

ttgaa

gcag

tata

actc

taca

ggag

atta

taga

agcc

atgc

agta

gaca

agat

ccaa

aa6

155

2428

715

PHT

FlY

ES

ggcc

acag

cgttc

agttg

atgt

ggttg

tatc

ctcg

gtttt

ccta

ctga

cact

ttcga

ttgct

t

g15

632

6150

0N

OL

Cl

YE

Sgt

ctgc

caag

gtcc

caga

gcga

aagt

taca

g

157

3144

008

NB

NY

ES

caga

ctttt

gact

ggcg

ttgag

tacg

ttgttg

gaag

gaaa

aact

gtgc

cattc

tgat

tgaa

aatg

atca

gtcg

atca

gccg

aaat

catg

158

3527

425

PAR

P2Y

ES

atct

gtga

aggc

cttg

ctgt

taaa

gggc

aaag

ctcc

tgtg

gacc

caga

gtgt

acag

ccaa

ggtg

159

3836

942

—N

Ota

ccag

gagc

ccat

ggat

ggcg

tgac

ccag

cagg

cagc

acag

aatg

tact

tgcc

aagg

cggg

caaa

gagt

aaac

c

160

2746

889

—N

Ogg

agtc

aaac

gtca

gagc

ctga

gacc

tttga

tgaa

gggt

caca

tcgc

caga

gctc

agtg

g

161

2853

401

—N

Ogc

tgag

agct

agct

ttgct

ttata

atttt

gtac

ttact

aaaa

aatta

aata

actta

taaa

tgga

ggaa

aact

tgga

tcag

ttgat

agat

tttgg

ggga

gtta

gtga

aattt

cttg

aggg

gattt

tcaa

tcga

atgc

tttta

ttttc

tgtg

gcag

taat

gatc

tggt

tggt

ttatc

tcat

aaat

aact

gatg

ctgc

tgct

ttttg

tgttc

tttga

tgtc

tca

cctta

tgttt

ttact

aagt

aagg

acag

caat

ggat

tggc

ttctg

atgc

162

3593

678

USP

8Y

ES

tgtc

ctgc

gcaa

tgag

ccttt

ggttt

taga

ggga

ggct

atga

aaac

tggc

tcct

ttgtta

tccc

163

2466

363

—N

Otg

ataa

ttggt

gacg

acaa

ggaa

atta

agac

gattg

ctca

aaga

gatg

ca

164

2961

018

—N

Oga

tcttc

caca

caaa

gatc

aggt

gaag

aaat

ctat

gcag

ctat

acat

gcta

ggac

ctgt

tgta

cacc

atcc

ctgc

aa

165

3307

825

NO

ctga

ggaa

tctta

aatc

tggg

tata

aacg

tgaa

atgg

tttta

tttttt

cctta

ctgg

gtct

ccag

tcat

acag

tgta

aaac

actc

ctaa

cctc

tgta

ctttc

ctct

gca

gtgc

agtc

cttta

agaa

tccc

ttggt

ccga

tgta

acttt

gccg

ccac

t

166

3375

666

FTH

lN

Oga

cccg

cagg

gcca

gacg

ttcttc

gccg

agag

tcgt

167

3510

380

C13

orf2

YE

Sgc

agct

gcca

ccgt

ttctg

gaat

gaac

ctgc

tgaa

tact

gtcc

ttcct

gtgt

tccc

aggg

cagg

tctc

ctca

gccg

ttcac

acac

ctca

gcca

tcaa

tacc

aaa

3cc

caac

agtta

tcag

aacc

ccttc

attg

ccca

ctgc

acct

gtta

catc

catc

caca

gtac

aacc

acca

ctcc

tgttc

cttc

cattt

tttct

ggcc

tagt

gtca

ctgc

cagg

tcct

tctg

ccac

tcct

accg

cagc

cact

ccta

cccc

agga

ccta

cacc

acgg

tcca

ctct

tggt

tcca

gtga

agca

tttgc

ttcta

cttc

tgca

ccttt

cact

agcc

tccc

ctttt

ccac

cagc

tcttc

tgct

gcttc

tacc

agca

accc

aaat

tctg

cttc

attg

tcat

cagt

ttttg

cagg

gctc

ccttt

gccc

ttacc

acca

acat

ccca

aggc

ctat

ccaa

cccg

actc

ctgt

aattg

ctgg

tggc

tcta

ctcc

cagc

gttg

ccgg

tcca

cttg

gtgt

gaac

agtc

ctct

tttgt

ctgc

gtta

aaag

gttt

tctg

acat

ccaa

tgac

acca

attta

atca

actc

ctct

gcttt

atcc

tctg

ctgt

caca

agtg

ggct

ggct

tca

168

4026

959

HC

FCl

YE

Sca

agcc

agcc

aaca

agcg

gccc

atgt

cctc

169

2888

352

RN

F44

YE

Sag

agca

gctc

ccgt

cgta

ccgc

tttaa

cccg

gaca

gcca

tcag

tcgg

agca

gacg

ct

170

3320

634

USP

47Y

ES

gaga

aattg

agcg

caat

acat

gcaa

g

171

3752

442

—N

Ota

ggtg

catg

acac

tgct

cagt

ttgat

gtgc

taat

ctga

ttcca

gtaa

agag

aattg

ctga

tttaa

tgttg

aggc

ccga

tcttc

caca

ggtc

ctaa

atgt

ttccc

aa

aata

catg

gata

gcat

acga

ctgg

gtttt

tttaa

aatta

tccc

aggt

caag

catg

agta

tctc

172

3188

731

NE

K6

YE

Sca

ggac

tgtg

tcaa

ggag

atcg

gcct

cttg

aag

173

3303

115

—N

Oct

ggac

caac

cact

acttc

cgtg

tttca

agttc

atttt

tagc

acat

gaac

atga

tcac

tgtta

gcca

gtga

agta

gcttc

tgac

taga

tcat

tgat

taga

tctc

aca

aaaa

acca

aaaa

tagt

atat

ggaa

acca

agat

gaga

gcaa

aaga

aaac

gtta

cctg

agta

ggca

gcta

aaac

atat

tttga

catta

ttttta

agca

gcat

tcat

OO

aagg

ttcac

gga

174

3820

685

ILF3

YE

Sgg

ttctg

gcat

ttatg

accc

ttgtg

aaaa

agaa

gcca

ctga

tgct

attg

ggca

tcta

gaca

gaca

gcaa

cggg

aaga

tatc

acac

aga

175

3882

554

—N

Oat

aatg

ggat

ggca

aata

gtct

cccc

agcc

caga

gttc

aata

tcct

cctg

gttg

ctgg

ctga

gctta

gact

agaa

ttatg

ttgag

tttcc

agga

cacc

cattt

tacg

aatg

ttattt

tgaa

ttgcc

tgttg

tatg

tgat

aata

176

3054

154

NO

ctac

acgc

tgcc

gagg

aaaa

cgca

acag

acat

ggca

ggtg

cctc

acga

caag

aaac

actta

caaa

taga

atca

aaac

tgat

tcaa

gtca

taca

177

2624

472

CA

CN

AY

ES

atcc

gcgt

aggc

tgcc

acaa

gctc

atca

acca

ccac

atct

tcac

caac

ctca

tcct

tgtc

ttcat

catg

ctga

gcag

cgct

gccc

tggc

cgca

gagg

accc

cID

atcc

gcag

ccac

tcct

tccg

gaac

acg

178

3652

530

POL

R3

YE

Sga

ctgc

tgtg

taag

ctat

ggtg

gcat

gtgg

tacc

ttaaa

ggga

cagt

acag

tcttg

aE

179

3980

537

AR

R3

YYEE

SSac

tacc

acgg

agaa

ccca

tctc

tgtc

aatg

t

180

2808

239

NO

caca

ggtg

aattg

tctg

ggaa

gtca

ggat

gttg

caca

gaag

ctat

gcaa

gtca

taga

ttaga

aaag

caag

aatc

caca

ttcat

gcttt

ccag

cata

gatg

agga

gata

ctttt

tctc

cacc

ttctta

gattc

agtg

gctg

ggca

gaga

gtgc

tgtg

aattc

atct

gaca

acag

gcag

atta

acac

gaga

aaag

gaat

ataa

gtttt

ttat

ttttta

tttttt

tattt

ttttg

ttttg

agac

agag

tgtc

actc

tgtc

tccc

aggc

tgga

gtgc

agtg

gctc

actg

caag

ctcc

cacc

tccc

gggt

tcac

acca

ttctc

ctgc

ctca

gcct

ccca

agta

gctc

agac

taca

ggcg

cccg

ccac

catg

tcca

gcta

atttt

tttta

tttttt

agca

gaga

cagg

gtttc

acct

ccca

aagt

gctg

ggat

taca

ggca

ttagc

cacc

gcgc

ccag

ccaa

gtttt

ttaat

gttta

atct

aatg

tgca

tgga

ggca

tcat

agaa

agaa

ctga

atat

ccaa

aagt

gtgg

tgaa

atttg

agac

tttag

atac

catc

ttaat

gata

gtgg

cagg

aggc

agac

aaat

ccta

ggga

gaca

aggg

tggg

tccc

tggt

gaaa

cccc

acct

tcaa

acca

aaga

cagt

ttaaa

gcat

gaaa

gcca

agct

acaa

gtct

ccag

taaa

tcca

tgga

ccgg

atta

agaa

tctc

tc

181

2811059

—NO

ccat

cagc

ttgtg

actc

atgg

ctta

gctg

gtct

caat

gggg

aaca

aacc

agag

agtc

tatg

gatc

aaca

caaa

gcta

taac

tgc

182

2858392

___

NO

ggcc

cagc

ttcat

ggat

atac

aaac

tata

cattc

acat

gggt

tcca

cacc

taga

tggg

ctct

taca

tcat

gtag

ctgg

tcct

acct

ggga

gaga

gc183

2779739

___

NO

tctg

ttcac

ggag

ctta

gttc

tact

tcct

ga184

3298972

___

NO

gtta

acta

tagg

tagg

ggac

agag

aaag

gagc

agag

ttaat

gtat

gcta

ttgaa

gctg

agttg

ctat

cagt

ctga

acta

gact

ttgaa

ctca

gcat

g185

2933580

TULP4

YES

gaaa

ctgg

ccac

gtgc

gatg

cgga

cgga

ggca

tattc

gtgt

ggat

tcag

tacg

aggg

cagg

tggt

ctgt

ggag

ctgg

tcaa

cgac

cgcg

186

3528128

TOX4

YES

caac

tagg

ccaa

acca

gtac

agct

acta

tcc

187

3528025

NO

cggc

gcta

cgtta

acttc

gact

atat

taat

gagc

atca

cgat

cttc

atttt

catg

atcc

cgta

gtcc

tcgc

ggtc

gtag

aaaa

tgaa

agga

aagc

agcc

gtta

aO

Oca

cagg

aaga

gcga

aaaa

agga

cattt

tccc

tggc

gatc

gtgg

c

188

3581

134

AK

Tl

YE

Sga

tgat

ctct

ccac

ggta

gcac

ttgac

ctttt

cgac

gctta

acct

ttccg

ctgt

cgcc

ccag

gccc

tccc

tgac

tccc

tgtg

gggg

tggc

catc

cctg

ggcc

cct

ccac

gcct

cctg

gcca

gacg

ctgc

cgct

gccg

ctgc

acca

cggc

gtttt

ttta

189

3676391

—NO

tggg

ccat

ctcc

tcgg

taca

ggtc

agct

gccg

ccgg

cgga

gctc

ctca

tctg

tctc

ct190

2319003

—NO

ccaa

gagc

ccgg

aattt

tcat

taca

acttt

caaa

gaga

gcaa

gagg

agga

ggga

aaaa

gattt

caca

aaag

catta

tcaa

ggcc

ccaa

ccca

ggat

gccc

tgct

gtac

aacc

aaaa

tttgt

aaga

ggtc

agcc

tttca

ggga

gtca

aaaa

ccca

gcat

gtgg

a

191

2858313

—NO

ctgc

agag

caaa

atat

agag

gcac

taat

tttgt

tata

tttgc

agcc

caca

tact

gtaa

tacc

agat

ttgct

cctg

ttgttc

t192

3048750

—NO

cggg

aaac

ttcgg

aaga

cagc

tgtg

cctg

gctc

tgtg

gctg

catg

cagt

gcttc

acttg

gcca

gcag

aggt

cagc

tgtg

ccga

gctg

cccc

agcc

atga

gaa

gaga

agcc

tgcc

cttg

ctgg

cagg

tggc

tatg

gccg

gccc

agag

ccttc

ctgc

ccag

ctcc

tgca

gccc

tgct

gcct

ggga

tcag

gctg

ggag

atgg

gcct

tcct

gacc

gcca

gcct

tcct

ctcc

ccga

gcac

acgc

acat

gtag

attc

gggg

ggaa

gctg

cctg

ctct

tcct

taga

ggag

ccgg

ggca

gcta

tctg

ctg

gtcc

ctttc

tgaa

caac

tgttg

a

193

3360

848

APB

Bl

YE

Stg

agga

gggg

acgt

tgac

cttc

cca

194

3387

192

CW

C15

NO

gcca

agag

tggt

aatg

gcgt

ctgt

atga

tcttc

ggag

cctg

ctgc

atcg

gacc

tcgg

c19

538

9388

0—

NO

actc

cgca

gggc

tggc

acttc

ctga

ggga

gtgg

gggc

tcag

gcttc

agac

ggac

tttat

taaa

atgt

gtag

tttgt

gtga

atca

tttca

gtca

aaag

tttca

gct

atac

tcgg

ccgt

taag

acaa

ctta

atga

196

2393

792

KIA

A05

NO

ggaa

gggc

tgcc

atag

ttgcc

gcag

t62

197

2395

248

RE

RE

NO

tcac

agca

gcga

gcat

ccag

ggttt

gcag

ggac

gatg

ttaca

gact

ctgt

tttct

gcct

ggcg

tttca

cttg

tgtc

tgct

ccta

gcct

gtgc

tctg

ccag

cagc

acag

acat

ctgc

tcca

tcag

acct

cttc

cattt

tgca

cagg

gagt

gcag

gagg

tgaa

tgttc

acttt

ctgt

tctc

cagt

gtca

ctgt

tctg

tttcc

acgg

gatg

gaaa

gcgc

atgg

gcct

gtgt

ccat

tgta

gattt

ccttc

taga

tttct

gtgt

acac

acac

ttgat

tgttc

tgga

tgaa

tgtc

tttttt

aata

ctcc

gaaa

atttc

atca

tcta

agaa

aatg

attc

cata

caaa

taac

tcag

caca

caag

tgac

ccag

gaca

tatg

cctg

ccaa

aggg

atgt

gtta

gaag

gctg

ccttc

tcat

gcgc

attg

tcac

ttgg

atct

tgtg

gtga

ggac

ggcc

ccat

ctttc

ttgcc

acag

attg

aggc

cact

tttga

gcaa

ggga

gatc

ctgg

agtta

agac

aggt

gttg

gggg

cagc

ctgt

atttt

accc

tagg

ggca

ggtc

tgca

tggt

gacc

ccac

attg

cact

ggta

aacc

atttg

agtc

ccac

tcttc

atcc

tgga

agtg

ggaa

ctgg

agtc

ccac

ccac

agtg

cattc

agaa

agca

tgct

gtgt

gggg

gctg

cttc

tcag

gagg

ccag

gccc

ttctg

agcg

gaac

cgtc

ctgg

agag

agcc

tgcc

ctcg

tttcc

aggc

tgca

gccg

taac

gcac

tttc

198

3403

226

UN

Q29

NO

ctca

ccct

tgag

gccc

gggc

acttc

6319

939

2095

6—

NO

ccca

aatg

tgag

ttgca

tcaa

attc

ggta

aatg

taga

gtat

gtttg

ttttc

tctg

taca

caat

actg

acgt

cagt

gcta

gtgc

ctgc

ctaa

actc

agac

acca

gta

gatc

ctttt

ccag

a

OO

200

3970

256

RE

PS2

YE

Sttt

gaaa

agta

ctat

caat

gaag

cctta

ccaa

agga

cgtg

tctg

agga

tcca

201

2724

115

—N

Ogc

aggc

ctta

ctta

tttcc

acag

gacc

ttata

agct

cata

cact

ctat

tgct

tatta

cgtta

ctgg

aatc

tatc

taag

caga

aaga

ggct

ggcc

cacc

ttctg

ttat

ctat

gtttc

tata

ctct

ttgga

cttg

cta

202

3351

955

MIZ

FY

ES

caac

caca

tgcg

ctttc

gtca

cagt

gagg

accg

gccc

tttaa

atgt

gact

g20

331

3323

4PL

AT

NO

ggaa

ttctg

cttc

actc

gctta

acat

atac

acaa

cacc

tgta

acat

acaa

ggca

atgg

gcta

ggtg

ctcc

agac

cggg

aaaa

ggag

ggac

agga

atgc

ttggt

ctga

tggg

ctaa

tatg

gcat

ttaga

gaag

tacc

aagg

taca

gtgg

agcc

ggtc

acaa

aagg

gcag

acttg

t

204

2723

089

NO

tttgt

ggct

gtta

atag

gaag

gatg

ctgg

t20

531

0265

2N

Otg

tggc

aaac

tacc

acgg

caga

tgttt

acct

atgt

aaca

aaac

tgta

catc

ctgc

atgt

gtac

ccct

gaac

ttaaa

aagt

tgaa

aaaa

aaaa

aaaa

agaa

aca

aata

ggct

gggc

atgg

tggc

tcaa

tgcc

tgta

atcc

cagc

acttt

ggga

ggcc

aagg

tggg

agga

ttgct

tgag

gtca

ggag

ttcaa

gacc

tgat

atag

tgag

acc

206

3392

531

—N

Ottg

gact

tgaa

tgac

tagg

agaa

tgac

tact

ctaa

tgaa

caaa

aatg

taaa

tgtta

tatg

tggg

tttag

taag

ggaa

tgca

atga

acttg

gtttt

ggat

atgt

taaa

cttg

agtta

tcac

tgga

acat

tcag

gtag

aaat

gttta

gaaa

gcag

tttga

aata

agag

tttag

taga

aagg

ttgag

agca

gcgc

tgca

gata

caga

tttga

aagt

catc

tgca

aaga

gatg

tgtc

ttagc

gttc

tc

207

4015

009

—N

Otg

gagg

cggc

ccta

cacc

tggc

aatg

gagg

t20

825

9617

0IN

O80

DY

ES

gatg

agttg

ccgg

atga

cattg

ccaa

tgag

atca

ctga

cattc

caca

tgac

ttgga

attg

aacc

agga

ggac

ttttc

agat

gtcc

tgcc

acgg

ctac

ctga

tgac

ttaca

aga

209

3591

676

—N

Oaa

aacc

tgga

atgc

tgta

ggac

atgt

accc

actg

aggc

ggat

gcaa

ggag

cgat

ggag

agga

agga

210

3680

412

NO

tttac

ccct

tctc

ggtg

acat

ttgc

211

3906

169

CH

D6

NO

ctgc

ttgac

ttact

gggt

gata

ttggg

ctac

aact

gaga

ctca

ctttg

ctcc

tgtg

taaa

gtgg

ggca

acag

catc

tacc

acgg

aggg

ttgaa

gattt

acgg

aga

tcat

gcta

agac

agttt

gttc

caaa

ctca

aagg

aaat

cattt

gcaa

acaa

caga

aaag

gtca

gaaa

ccgt

atac

ctgg

ccaa

gaga

gatc

ccttt

tacg

ctttg

tttaa

tgttt

catg

ttgta

ttttg

ggttt

tccc

attta

ctgg

attc

tgag

ctcc

aaaa

cagg

aatc

acat

tttat

gtttt

ctta

tttta

aaag

caat

aata

ataa

ctag

tac

ttattg

agtg

ccta

ctgc

ttacc

atgt

tcaa

ggct

ttaca

tgat

tatc

ttgttt

gttc

ctca

caac

cact

ctga

agat

gggc

tttgt

tattc

ccat

tttat

aggt

gag

gaaa

ataa

ggct

ttaaa

gcat

taaa

taat

ttccc

caag

atta

tcca

gcta

gtaa

gtga

caaa

gcag

gaaa

ccaa

acca

agga

ccttt

ttctc

tagg

ggct

gag

a21

228

0310

2N

Oct

atat

gtag

ctac

cctg

tggc

ctcc

ccct

aagg

taac

cact

ttact

tttta

gtag

tgaa

gaat

gtct

aaaa

tata

ataa

aggt

atat

ctag

aaca

caaa

cctc

caag

cagg

aaca

accc

atta

tctc

tcct

ttgca

tgcc

ctgt

caat

ggct

tcaa

ggtc

aaag

ctag

ctaa

gtct

ctga

gtgt

gtag

ggag

ctga

catc

ttggt

gaaa

agtc

cttc

agta

catg

ctag

atca

tagc

tgac

ttgca

ctat

ccttc

caaa

ctttg

gaat

atct

ctct

ggta

ttgga

ttggt

taca

atgg

aaac

agaa

agat

tctg

atca

taca

aaat

aaag

atttt

cattt

gtga

gctc

aacc

attg

gatc

tgtc

atct

tcca

ttagt

agaa

aaaa

tgag

gaaa

tcaa

atac

tttgt

tttgt

tttta

acca

cgca

gag

aagg

aaga

gagt

agag

tgtg

ggaa

attg

atat

atct

gcct

tact

gccc

cagc

ccct

ccct

ctgg

agtg

tgca

agtg

gtca

gaag

tcag

caaa

ttact

tttc

catc

atat

ttggc

ccca

aact

accc

tggt

gagt

gagg

agaa

aggg

aatc

atttg

ataa

ggttt

ggaa

aata

gcat

ctgt

ttttc

ttagt

gtttc

tgga

tgaa

tttat

cagg

catc

cggt

aattt

gtac

tttct

gttg

aaaa

ctat

aata

gaat

accg

tgca

taga

catg

aaac

ctttt

ggta

ttagt

caga

agct

acat

actg

actg

ctgt

tgg

agaa

gacc

acat

ttaca

gtca

aggg

taga

atca

tctg

aaat

agttt

cccc

tgga

aaaa

aaaa

aaac

atgg

ccat

atat

gcct

acat

agat

ctcc

tcttt

gcttc

atg

aattt

ggaa

ctaa

acct

gggt

gttta

gata

attc

cagt

tcta

ggat

tttct

cacc

ttgag

tttat

tccc

ctta

ttctta

ctag

ttcag

tttgg

ccac

tgta

cata

tgga

gctta

ctag

aggc

aaag

cact

ctgt

gagg

ggca

atgg

ttata

ca

213

4025

793

—N

Ottg

tgtc

tgct

ccaa

gtgc

gaac

cctc

catg

cact

gcag

agaa

cacc

agaa

ggag

agga

gcac

tacc

tgag

cttc

tcct

tccg

ggtc

taaa

ggtg

gaac

ttgct

ttgca

gcac

ccag

cattt

cact

gtac

tgat

tcct

tttttt

ggat

cacc

acct

cctg

cgttt

agca

gccc

atat

gctg

ggct

cact

cagc

tata

cact

gcttg

214

2616

236

FBX

L2

YE

Saa

ttttg

gagg

ctgc

ccga

tgct

ccca

tttga

ctga

cgca

ggttt

taca

ctttt

a21

529

5983

2L

OC

lOO

NO

tccg

gtgc

ttacc

tcta

actg

ataa

aact

agct

ccaa

ccca

ccac

cctc

cact

gact

tcct

tcgc

actc

agcc

cact

cgca

cccg

ggtg

aata

aaca

gcct

tt12

8757

gttg

ctca

cact

tagc

ctgt

tcaa

gttg

tctc

ttcaa

ttaga

tgct

cgca

taac

atttg

gtgc

cgaa

agcc

cggg

atag

ggga

actc

ctcc

ggca

gacc

tctc

ctct

atcc

tccc

ggta

ccca

cgttc

tccc

atgc

aaga

gact

tccc

tcgc

cctc

agga

cctc

agac

cagc

tccg

cgag

cact

ccgg

cctc

tgtc

tatg

ga

216

3072

195

NO

ttagt

gtcg

tcag

gaga

ctcc

ctcc

atca

gaat

tact

cagg

ctga

ttgttt

tgag

tcct

ggga

ccca

gttg

gtat

ccag

aatc

ttggc

ttgttt

gcct

agga

acc

217

3757

471

AC

LY

YE

Sgg

gtgt

caac

gagc

tggc

aaac

tatg

ggga

gtac

tcag

gcgc

cccc

agcg

agca

gcag

acct

atga

ctat

gcca

agac

tatc

ctct

ccct

catg

accc

gaga

gaag

ca

218

3986

531

NO

gagg

gagg

aatta

cgtg

gtga

agga

tgaa

gtga

acag

cggt

gcttg

gcat

ataa

gcca

gccc

tcaa

acaa

g

219

2696

767

MSL

2Y

ES

cttc

ctgt

agct

ggtg

caaa

gact

atga

gcag

tttga

ggaa

aaca

agca

gtta

agca

tcct

agtg

aact

gcta

caaa

aaac

tatg

cgag

tata

taac

acag

acta

cact

ggca

cggg

atat

aata

gaag

cagt

tgac

tgttc

ttctg

atat

tttgg

ctttg

ctta

atga

tgga

tcat

tgttt

tgtg

agga

gaca

gaaa

aacc

ctca

gatt

catc

cttta

ctttg

tgttt

gaca

cattc

ccct

ttacc

ttcaa

cctc

agaa

ccca

caac

tgat

cctc

aagc

tagt

ttatc

tcca

atgt

ctga

aagc

accc

tcag

cattg

ctat

tggc

agttc

tgtta

tcaa

tggt

ttgcc

tact

tata

atgg

gcttt

caat

agat

agat

ttggt

ataa

atat

tcct

tcac

ctga

acat

tcaa

atac

gattg

acgt

atgt

aata

ctgt

tgac

ataa

aaac

tgag

gatc

tgtc

tgac

agcc

tgcc

accc

gtttg

tgac

acag

tagc

cact

gact

tatg

ttcca

cagg

cattg

atat

ctgc

agttt

cag

tgaa

gata

taaa

acct

ggag

actc

tctg

ttact

gagt

gttg

agga

agta

ctcc

gcag

ctta

gaaa

ctgt

ttcaa

atac

agag

gtct

gttg

ccct

aattt

gcag

ccga

acttg

gaag

ccac

tgta

tcca

atgg

acct

tttct

gcag

ctttc

ttccc

agtc

tctta

gcca

taat

gtttt

tatg

tcca

ccag

tcct

gcac

ttcat

gggt

tatc

atgt

acag

cagc

aact

ccga

agat

agca

aaat

tgaa

taga

aaac

gatc

caga

tcag

agag

tgac

agtg

agaa

agttc

agcc

acttc

caat

ttcta

ccat

tatc

cga

ggcc

caac

actg

gggg

catc

tgct

cctg

tgac

agtg

aaac

ggga

gagc

aaaa

tttct

cttc

aacc

tata

gcaa

ctgt

tccc

aatg

gagg

caca

acac

ctaa

aatc

agca

aaac

tgta

ctttt

atct

acta

aaag

catg

aaaa

agag

tcat

gaac

atgg

atcc

aaga

aatc

tca

220

3188

391

NO

cagg

ggta

cacc

caca

tcta

ttgta

ttaga

caaa

tcac

agag

ggat

tgca

acag

aaca

caga

tttttc

tcac

tgttt

tttct

ctgg

ttgat

cggg

atgc

atta

tcc

acca

gaaa

acac

tgta

gacg

actc

actc

acca

ggaa

aaga

gcat

atgc

cagt

tgga

ataa

ataa

aggg

gaag

agta

agga

agag

gctg

taga

atta

tttta

taaa

ttatc

aagt

ctta

tgag

ccag

gtgc

221

3846

196

—N

Otc

tggc

caat

gcat

atta

ctta

aggg

caat

gtcg

tggc

cagc

tgtg

gtgg

tctg

ggct

ctcc

ctct

gtat

cgcc

tggg

gagg

ctgc

tgag

gtga

ctttt

tgga

a00 U

lga

aaac

acgg

gatg

agtg

tatg

atgg

tggc

tgtg

gaga

ccac

ccaa

aatc

ccgg

ggttg

gggg

caat

agtg

aatg

aatg

ggac

catc

tgcg

tggg

tccc

tac

acga

gatg

cttg

222

3070

747

NO

gagc

tcat

tctg

cgttt

ctta

ttgct

tg

223

3821

522

___

NO

gtag

ataa

ccat

ttgtc

gctg

ctttt

tctg

ttaag

tgttc

acca

cttg

tatc

attg

gctg

gcaa

tacc

tggt

ttgtc

atag

ttt

224

3875

001

___

NO

agct

cctc

ccca

gaat

acca

tgct

c

225

3279

450

C10

orf9

YE

Scc

aaag

tttaa

ttaat

ctcc

tgct

gacg

ggac

atgc

tgttt

ctaa

tgta

tggg

atgg

tgat

agag

a7

226

3541

293

PLE

KH

YYEE

SStc

tttct

ctgg

cctg

gtct

acaa

gaat

gtca

c

Hl

227

3547

709

TT

C8

YE

Scc

tgga

acgt

ctttg

aaac

tccc

tgga

acta

atca

gaca

ggag

ggcc

tagc

c

228

3875

261

—N

Ogc

caac

cttg

gtttg

tgca

gttta

agga

aaaa

agcc

atct

ccat

aaca

tgga

agtg

caag

atga

agca

gcag

gcac

tagt

gggg

aagc

tgca

gcaa

gtta

tac

agaa

aatc

tagc

taat

gatg

aggg

tggc

taca

ctaa

aaac

agat

tttca

atgg

agac

aaaa

cacc

cttc

tattg

gaag

aaga

tgcc

ctct

aaag

ctttc

ata

ggta

gaga

gagg

tcag

tgca

tggg

cttg

aaag

aaca

ggct

gattc

tcttg

ctag

aggc

caat

gaag

ccag

tgag

ttta

229

2584

791

NO

cact

ggaa

gaat

atag

gttg

gctc

agac

agtc

cata

ggaa

ggct

aaat

aacc

acgc

tcag

gaaa

tggg

cctta

gaga

gtgg

gaag

agaa

aatg

tatc

taa

actta

tatc

tcag

taac

agct

tgat

agga

cattg

tcac

tagc

agtg

ccac

cact

aggt

cctc

a

230

3204

563

KIA

A15

NO

ttgcc

agca

ctct

gaac

ccat

gcgg

gcta

atga

cctg

ccca

tcct

g39

231

3356

165

APL

P2Y

ES

cgag

actc

tgga

tgtta

agga

aatg

atttt

caat

gccg

agag

agttg

gagg

cctc

gagg

aaga

gc23

236

5089

1—

NO

taca

ctcc

ctca

ggga

cagt

cttg

ccat

ttccc

gtttt

tcat

tctta

taaa

caat

gccc

tggt

gcag

gggt

cagc

aaac

ttttc

tata

agga

gtca

gata

atct

ttttt

tttttt

ttgta

ttccc

ttttg

gcaa

tttgt

ttaat

tgag

ataa

aattc

acat

aact

taaa

actc

accc

ttttg

gtgt

atac

gattc

agtg

ctttt

tagt

atat

tttca

agat

tgt

gcaa

ccaa

cacc

acta

tcta

attc

caga

acat

tttta

tcac

ccca

aaaa

ggag

ccct

gtgc

caat

tagc

tatc

a

233

3829

699

GPI

YE

Sac

tgaa

gccc

ttaag

ccat

actc

ttcag

gagg

tccc

cgcg

tctg

gtat

gtct

ccaa

234

3971

251

CN

KSR

YE

Scc

tctta

tacc

taga

agtc

ccac

aagc

agcg

ttgcc

acgc

cttc

cagc

acca

tcag

taca

ccca

ccaa

aaga

gaca

gttc

tgcc

ctcc

agga

tc2

235

2359

255

...N

Oag

ttgtg

gagg

catg

tttat

aagc

agat

ctga

gtttt

gcca

cact

ggaa

tttat

ttat

236

2811

000

...N

Oct

gggt

ctag

gaag

ccag

gtac

tttgt

gctg

tttca

acaa

gagc

tcttc

tgct

ttaac

tagt

tt23

733

9198

6...

NO

gctg

gaga

agttc

gtct

ggga

caaa

gagc

tctg

gcct

catg

cctg

tggg

tcca

gcag

tcaa

actg

ggac

agac

tatg

tgaa

aagg

gacc

cac

238

3888

361

...N

Oag

cagc

ctcc

cgct

tagc

ggag

agtg

ggat

gagc

acat

gcgc

ggcc

gaca

ggga

agag

tgaa

tcca

gagc

agaa

gtca

aggg

caag

actc

gtgg

gggg

ggga

agaa

aggg

acag

aagc

cagc

tccc

agca

ataa

aggt

cggg

ttattt

tgttc

ttttg

tgac

atgc

ccta

tatc

OO

239

3897

502

NO

tctc

ctgg

ggac

ttaca

tagc

tgttt

ggttt

ttcaa

cttg

attg

aaga

aagt

tattc

gggg

gatc

tgtc

caat

tcac

acct

tctg

ttccc

tgat

caaa

tact

ttagg

gtca

aaca

taag

gtttt

attg

atttt

tgct

caag

caaa

gaat

taac

atttt

tgat

aagg

aact

gtaa

tggc

aatta

taag

gtaa

tatg

gtgt

atgg

taat

atta

tgct

gcc

agag

gaaa

cattt

gact

atga

ttaaa

ttcaa

gccc

agta

ctgg

gtag

ctct

agat

aatta

aaga

taat

tttat

ccat

tcaa

gtcc

cctc

tgtta

agct

gcac

attg

aca

240

3235

381

DH

TK

DY

ES

acag

tata

ttgtg

agca

tggt

cata

aagc

tgcc

aaaa

tcaa

cccc

ctct

tcac

cgga

caag

ccct

gctg

g1

241

3286

657

NO

tcca

gtga

ggcc

acat

catg

acttc

cccc

atga

agac

atcg

aattc

acgg

ctgc

cttc

acct

ttgtc

ctgt

caat

gtct

gatc

tttcc

tttca

atta

cagc

acga

ggc

tggg

gttc

ca

242

2714

224

MY

L5

YE

Stg

gacc

agat

gttc

cagt

tcgc

ctcc

atcg

atgt

ggcg

ggca

acct

ggac

taca

aggc

gctc

agct

acgt

gatc

accc

acgg

ggag

gaga

243

3331

851

GL

YA

TY

ES

tgaa

agta

gagc

attc

gaga

gcac

tcct

cttg

gtta

cgga

agat

attc

tgaa

gctc

aatg

cctc

cagt

aaaa

gcaa

gcttg

gaag

ctgg

Ll

244

3356

559

NO

gcca

tggt

tctc

ttgtg

gtca

gctc

ttgttc

taat

cctta

gcgc

ccat

ttgga

aacc

agtta

tggg

gaaa

gcac

aatg

tagg

actc

ttggg

actc

tgca

cctg

actg

gctg

gcttt

ccaa

gatc

actg

agat

ggct

cttc

ctcc

agca

taga

aattg

atgg

ctgg

ttatc

caga

cagc

aacc

tcttt

tgcc

catg

tgct

tggt

gctc

tgtc

atgg

cggg

aaaa

gtaa

ctat

gcac

agat

catg

atta

tggt

atta

gattg

ggta

caca

tgaa

attg

ctag

tatg

cacc

tattt

tgat

gtat

gaaa

atat

cattt

tcat

gaga

ttcat

ccta

attta

tgct

atgt

atgg

ggcc

tgat

tgcc

ctaa

cagc

tcat

c

245

3636

325

NO

atca

gaca

ccgc

ctat

tcac

cagc

tcat

ctat

aaaa

cccc

ctgc

atttc

accg

caga

actg

gaac

ctat

t

246

2539

613

NO

tcca

ttcttg

cgct

taaa

aact

gtac

ctaa

ctcc

ctcc

cata

gcag

acag

aata

ggat

aggc

ttcttc

ccta

cctg

gtgt

tcaa

gttc

tacc

actg

ccct

cctc

cc

ttccc

ccat

ttacc

tctc

taga

atta

ccag

gtat

ctat

gcat

acat

gaat

tctc

tgct

tcca

ttaga

tttac

ttgtc

attc

ccca

aata

cacc

atgc

acttg

cata

ttag

caaa

gcca

agttt

gtct

ttcac

aaat

gcag

aggt

taaa

taag

agtta

agga

tgaa

ggta

aacc

aaac

tttat

ttata

tact

atat

tttac

caaa

tatg

attta

agga

tct

ctag

gcag

tgttg

tctta

247

2860

647

—N

Ogc

aatg

tgga

ccag

acca

tcga

caac

ccct

atgc

cacc

tttgt

caag

atgc

tacc

ggat

aagg

attg

cctc

tacg

ccct

ctat

gac

248

3143

676

MM

P16

YE

Scc

cgat

gcgg

tgta

cctg

acca

gaca

agag

gtag

ctcc

aaat

tt

249

3492

475

___

NO

tggg

ctga

ccac

agac

tttac

caca

aa

250

3698

355

ZFH

X3

NO

gtcc

gagc

ctcc

gtac

tggg

tgca

atga

aagc

251

3364

564

—N

Oat

tggc

gtgg

ttcttc

ccca

ggat

acct

tata

gagt

ctag

tgaa

ctttt

cctg

tttgt

ggaa

acaa

tcag

gctg

ggttt

aaat

gagg

acttg

tctc

tattt

ggag

cat

ttgtg

agcg

tgta

agga

aatg

agtg

ttt

252

3101

645

AD

HFE

YE

Sag

ggag

ctttt

gatg

ccta

tgttg

ctgt

cggt

ggtg

gctc

tacc

atgg

acac

ctgt

aagg

ctgc

taat

ctgt

atgc

atcc

agcc

ctca

ttctg

atttc

ctag

atta

t1

gtca

gtgc

cccc

attg

gcaa

ggga

aagc

ctgt

gtct

gtgc

ctct

taag

cctc

tgat

tg

253

3015

159

ZK

SCA

YE

Sag

ttcat

ggac

ctga

gatg

ctcg

caag

gggg

atgg

tgcc

tctg

gatc

cagt

tcag

gagt

cctc

gagc

tttga

ccttc

atca

cgag

gcca

ccca

gtcc

cact

t

Nl

caaa

cattc

gtct

cgg

OO

254

2686

624

IMPG

2Y

ES

atac

ctttc

aagc

tgca

tggc

cctc

agca

gatg

aatc

catc

acca

gcag

tattc

cacc

acttg

atttc

agct

ctgg

tcc

255

2897

644

NO

atgt

tggg

tccc

acct

taca

tttag

tttca

tgtc

ccct

tagt

ttcct

ccaa

tctg

tgac

agttt

ctta

atttt

ttcttg

tcttc

tgtg

acct

tgac

acttc

tgaa

gaaa

aca

tttcc

ttgat

atttc

tgat

gaaa

atga

ttatta

tgta

gaat

gtcc

ttcaa

cttg

aattg

gtct

ttttc

tcat

gatta

gaat

gagg

ttctg

ggttt

ttggc

aagc

agag

aac

agaa

gcga

tact

atat

ttttc

tcag

tgcg

tcat

atcg

gggt

catg

atgt

cagt

gtgt

ctta

tact

ggta

cact

aacc

catg

tctg

ctag

gtttc

tttcc

aata

cagt

ca

256

3909

740

—N

Ogg

tgga

gcaa

gagc

cctg

ttggc

tgat

gg

257

4049

026

___

NO

ggca

caga

aggg

caaa

ttccg

caca

ttctc

atttg

tggg

258

2321

582

___

NO

atgg

agcc

agaa

aaac

gcgt

gcag

cagc

tcat

c

259

3304

498

AR

L3

YE

Sgg

cttg

ctct

caat

tttgc

gcaa

gttg

aaaa

gtgc

acca

gacc

agga

ggtg

agaa

tact

tctc

ctg

260

3533

002

___

NO

tact

gaat

gtgc

ttggt

tttgg

acag

261

3568

039

PPP2

R5

YE

Sct

cttg

ctgc

cgct

gcag

atcc

agtc

ttcct

ccE

262

3764

440

RN

F43

NNO

Otg

cgga

atttc

tcgg

cacc

tacc

tgta

gtat

gggg

cact

tggt

ttggt

tgca

gagt

aaga

aggt

ggaa

gaat

gagc

tgta

cttg

gtta

agca

gttg

aaac

ctttt

ttgag

cagg

atct

gtaa

aagc

ataa

ttgaa

tttgt

ttcac

cccc

gtgg

attc

cagt

gggc

ccga

ca

263

3790

080

NE

DD

4YYE

ESS

ttggg

aaag

caga

taac

cctg

aatg

acat

gga

L26

426

5800

5NN

OO

gtat

tatc

acat

gact

gcca

ggtg

c

265

3029676

—N

Ogt

ctgt

gggt

ggat

agat

ccat

taat

ggat

aagt

aaat

gagc

aatg

cttc

ctgg

gttg

aggt

tttgg

atta

ctgt

ggtc

atgc

actg

cattg

gaga

tgag

gtgg

aaa

aacc

atc

266

3390272

—N

Oga

gtgg

gcac

tagg

aaac

ggat

tcaa

agag

gcga

tgaa

taat

ctga

gtttt

acag

gttta

acag

gaag

gcat

aaca

ttgta

agca

aaga

aaga

aaag

atat

tcc

agac

aaag

cata

tgtg

g

267

2642810

DNAJC

YE

Sct

ggat

ggag

taag

agcc

tctg

gtaa

taga

gatg

tttgt

gtaa

aaat

gaca

ccaa

ccca

taaa

ggtc

agcg

atgg

gggt

tact

cagc

atgc

ctgt

tgat

gag

13

gaag

taga

gagc

cttc

acct

cagg

ttctta

gcta

cgcc

tcca

a

268

2811129

—N

Oga

tgag

atat

taac

tgct

gcac

tgg

269

3070222

AASS

YE

Stg

agaa

aatg

gtgg

atca

taga

ggag

tacg

ggta

gtgg

cattt

ggac

a270

3907114

TOMM

NO

cctg

cctg

acct

tacc

caga

gaag

ccat

gggc

cacc

tgct

ctgt

gccc

gctc

ctga

aacc

ca34

271

2790942

—N

Oat

gttc

ccat

aagc

aaca

gcct

gtaa

attg

tcac

atgt

aagt

catc

taat

aagt

ttaga

acaa

tgaa

caac

tcat

tttct

gaac

tggg

acaa

acaa

ggaa

gcta

aat

tca

272

3043075

—N

Oaa

tcag

tgttg

cctg

gtgg

atag

caaa

tcaa

gtttc

aagg

ttaca

ga273

2354095

WDR3

YE

Scc

atgg

tgaa

atgg

tggg

acct

tgat

actc

agca

ctgc

tttaa

aaca

atgg

ttggc

cacc

ggac

tg274

2713294

—N

Otg

gattg

cgta

aagg

tggg

gacc

tcca

gatc

ttcca

cggg

aaag

gtac

gtttt

tcttg

ttgat

attg

tgaa

gtgt

gtat

gggg

ttgta

ctttg

gcac

cttg

tagt

g00

agtc

agttt

cccc

ccat

tggt

gatc

attg

ccaa

atca

275

3220

577

KIA

A03

YE

Sag

atgt

tgca

tcaa

aggg

ccttg

ggttg

gttta

tgaa

ctag

gcaa

tgaa

caag

atca

acag

gaat

tggt

ttcta

cact

tgtg

gaaa

cact

tatg

actg

gcaa

aa6

8

276

3531

076

SCFD

lY

ES

tgtta

ctcg

tattt

tgga

caat

ctta

tgga

gatg

277

2505

303

RA

B6C

NO

gcag

gaag

aaaa

cttc

gagt

taca

ggtc

agga

aaag

c27

826

4404

0PC

CB

YE

Sga

gatc

atgc

ccaa

ttatg

ccaa

gaac

atca

ttgttg

gtttt

gcaa

gaat

gaat

ggga

ggac

tgttg

gaat

tgttg

gcaa

ccaa

ccta

aggt

ggcc

tcag

279

2938

530

—N

Oga

gaat

gccg

gtgg

ggcc

ttcag

cagc

agca

tcct

aaca

gtgt

tgca

280

3625

346

CC

PGl

YE

Sga

ggcc

ctac

tatg

caaa

atga

tgga

agga

aaga

aaag

ccag

ttcac

tttaa

agaa

ttcag

aaaa

aata

caaa

ttcaa

agaa

atgc

agtc

ctgg

gcat

gatt

gtag

agaa

aattc

tcat

tcttt

caga

aagg

cttg

ttctg

gtgt

atttg

attg

tgct

caac

aaga

gtcc

atga

gcct

tttta

acac

agtg

gtga

atc

281

2971

361

—N

Oct

gcct

agta

ttgtg

ctac

agta

ccag

acaa

aatc

acttt

aggg

ttttg

ggga

ttttg

tttttt

taaa

caaa

ctgg

tatg

taat

ataa

actta

ggaa

ccac

cacc

acca

tctc

gagt

atca

atgt

ttcag

aatg

gagg

cata

gttc

agtg

aaaa

aaat

gccg

gcat

tggt

tttag

ttttg

attc

ttgttt

cacc

agaa

agca

tggt

ggttg

gggg

agct

gtca

aagt

actc

cgga

taga

ctca

gcgc

catta

aata

agct

cagg

cata

tacg

gcca

ggag

caa

282

3026

661

TR

IM24

YE

Saa

gtgt

gagc

gcct

acttt

tattt

ct28

331

0890

6-.

-N

Oct

gcat

cgaa

ccag

cgac

ctgg

gtgc

ctcc

ccac

ccaa

gacg

gacc

tcca

catc

ggga

a28

436

4913

4M

KL

2Y

ES

ccag

cagc

ccttt

atca

ataa

ggcc

tcca

acag

tgttc

ttcaa

tcca

gaaa

tgct

ccgc

ttcca

tccc

tgca

285

3729183

CLTC

YES

ttattg

aagt

tggc

acac

cacc

taca

ggga

acca

gccc

t286

3900156

C20orf7

YES

tccc

aaca

aaat

cgtg

gccc

aggt

agct

tgcg

atgt

ccttc

agttg

ctgg

tttcc

tact

ggga

gaag

cttc

agat

gtttg

aaac

ctct

ctgc

ctcg

gaaa

atgg

4c

287

3907653

NCOA5

NO

tttcc

tcttt

ggaa

ctct

tgtg

ttgtt

288

3102604

—NO

ttggt

cttc

acgc

actg

ggtg

tgtc

tgta

aata

cagc

gctg

tcca

cggt

gtct

gtcc

tgct

tcca

tccc

aaat

tcag

gcttt

agct

taaa

acat

cttta

gttta

atttt

ttaaa

aaat

tcttt

tcttt

cccc

caga

taaa

atct

taat

ctttt

gcac

taga

ctgt

tagc

cagg

gaaa

289

3863282

NO

gaag

tgttt

ccag

acat

ccca

attc

290

2920506

-__

NO

gcttc

ttcgt

ggtc

ttttc

catta

t291

2319069

___

NO

ctga

agca

gggt

gccc

gtttc

taca

ccaa

agag

cggc

aaaa

tgaa

gaa

292

2573693

CLASP

YES

gcttc

tggg

cctg

caga

actta

ctga

aI

293

3022667

SNDl

YES

gtgc

ccga

gtag

agaa

agtc

gagt

ctcc

tgcc

aaaa

taca

tgtc

ttcta

cattg

acta

cggc

aac

294

3570810

—NO

atgt

gggt

ggag

atga

tcttt

gcttt

gaga

acag

gattc

atta

tgtg

ggct

ggtc

agga

gtgg

gaac

aaga

gcag

gaag

gcca

cagg

ggat

tgag

agta

cttc

tgtc

ccca

acac

actc

atca

agga

cgtg

caat

cggg

ggcc

aagg

ctca

ttatg

gtga

ttttc

a

295

3847162

—NO

tggc

cagc

tccc

tagt

ttgtg

ctta

ctat

acct

ggcc

acgc

ctcc

ctac

ctaa

ggcc

gctg

gctta

accc

tagg

ggca

ggca

gtgt

taga

tcag

accc

agac

cttc

tcat

ccca

ccct

catc

acat

cggg

gaga

gggg

actc

cagg

ggcg

ggaa

ggca

ggcg

tccc

tcca

tttgg

ccag

ggtg

ggcg

gcga

ggag

gggg

tcac

tctg

cagg

aaca

ctga

gctc

tgaa

cacc

tct

296

2535304

NO

tcaa

caac

atga

atgg

cggc

aaca

ctag

gaga

catc

c297

2697615

-__

NO

tgca

gtgg

tact

atttt

agct

caat

gcag

cctta

gattc

ttgga

ct298

2931795

-__

NO

agat

ggca

tgct

gcac

aagg

gattc

atgg

ttaca

gcgg

gcttg

tggg

actg

gggc

tctc

caat

acgt

ggttg

ggttt

gtaa

agaa

atca

ga299

3011882

STEAP2

YES

cagg

ttattg

aact

tgcc

cgcc

agttg

aattt

cattc

ccat

tgac

ttggg

atcc

ttatc

atca

gcca

gaga

gattg

aaaa

tttac

ccct

acga

ctct

ttact

ctct

gga

ga300

3464921

—NO

cctg

ataa

taag

agga

acga

ggac

agct

caga

aagt

acaa

gtca

agaa

gccc

tgag

aggg

gagt

gaat

tcag

gaaa

ccgg

acat

ttcag

gtttg

cctc

agc

attg

catg

agttt

gagg

aaca

agaa

aaga

tgag

gatg

gattg

tgaa

tgat

ctcg

aatg

tgttt

tgaa

ggttt

ttgga

ggta

tttgg

attc

accc

taag

a

301

3541610

—NO

aggt

cgat

gggc

tcag

aattc

actg

acag

gttc

agat

ccag

ccga

gaag

tgga

gcat

gtat

ggta

ttagt

ggca

tttga

aggt

catta

gtgg

cata

acta

ttgt

agtg

taaa

ttcaa

gtttt

attg

gtat

attg

tgta

tagc

cctg

caga

302

3872499

NO

ttagg

agcc

atca

acga

gttc

acgc

cgga

gaaa

gacc

tttca

agtg

tgga

gaat

gtgt

gaaa

tcttt

cagt

cata

agcg

cagc

cttg

ttcac

catc

agcg

agt

tcac

agtg

gaga

aaga

cctta

tcag

tgtg

gaga

atgt

ggga

aatc

tttca

gtca

aaag

ggca

acct

cgttc

taca

ccag

cgag

ttcac

actg

gagc

aaga

cct

tatg

agtg

tgga

gaat

gtgg

gaaa

tcat

ttagt

tcaa

aagg

acat

ctta

ggaa

ccat

cagc

aaat

tcac

actg

ggga

caga

cttta

tgag

tgtg

gaga

gtgt

ggga

aatc

tttta

gtca

taaa

ggca

ccct

cattc

taca

tcag

cgag

ttcac

ccta

gaga

aaga

tctta

tggg

tgtg

gaga

atgt

ggga

aatc

tttta

gttc

aatc

gggc

acct

tagg

agcc

atca

gcgc

gttc

ata

303

2470335

—NO

aagg

cgttc

gtta

tgtg

ggat

atgc

tgtta

ccac

tgaa

cttg

aagt

tatc

aaag

aagt

304

2887649

___

NO

ggta

agtg

gattg

acct

ctaa

actc

ccta

gaag

ggct

gtag

ctttg

aagg

tgga

cattt

attg

ggct

cgca

cgtg

acac

ttattg

gggc

taa

305

3522210

___

NO

gtga

gaac

ctac

atgt

tggg

tgcc

cacc

306

3674221

—NO

agtg

agcg

tttga

gtga

acca

gcca

cagt

ctct

acgt

gtca

tcca

agga

gccc

ggca

caga

cccc

gtgt

cacc

ccca

tgtc

accc

gcag

accc

cgcg

tca

ccca

taga

tacg

caca

307

2560167

NO

ggga

caca

gagc

agttg

agga

tatc

tcttt

tcttt

cact

ctgt

tctg

aaat

ctgc

ctct

tccc

aaag

gtac

tcca

tgac

ccct

aaga

tact

cact

ctg

308

3041159

___

NO

ttaat

tcag

caca

actc

acca

ttccc

actg

gaaa

cata

ctgg

caat

tcac

atct

tcca

aaca

agg

309

3183335

FKTN

YES

gagg

cact

cagg

ccaa

aaca

ggaa

aaa

310

3204049

___

NO

gggc

gcca

tcgg

atgg

ggca

aaga

gatc

cctg

aaaa

cgta

ttgcc

gggg

gacg

ggga

cttg

cagg

acaa

gaaa

accg

tggg

agaa

t311

3393003

KIAA09

NO

gttg

attg

taaa

ccca

cagt

atct

agca

gcgt

tgtg

ccaa

attg

ccct

tgtg

tttct

ctcc

accc

aaaa

tatc

acag

ctgc

tttcc

tcac

atttg

gttc

atcc

gtgt

g99

ctgt

tcttt

t312

3598130

—NO

gcca

agta

caaa

gtgc

tgtc

ccat

atat

tacc

tttat

catc

atga

caag

cact

tgag

atgg

taat

taac

aact

ccac

tttaa

gtct

gaga

ataa

tgaa

gcaa

ctg

accc

aagg

ctcc

aaag

acag

tgaa

tggc

agag

atga

gattc

aaac

ccag

gtct

ccct

gact

cgaa

agcc

cacg

ctttc

cccc

aaca

ccat

gttc

ttttc

cttc

cctg

tcag

aaag

ggaa

atac

caaa

aaca

aatg

aggg

tatg

tatg

aggg

tttgg

ctgg

agcc

ccag

tcag

ccaa

agtc

tgat

tcca

agtg

gact

gcag

ggt

ccgt

gtta

tctc

ccttg

ggca

caat

ctca

aaag

ccca

gaat

tcag

ctgc

cttg

ctaa

ccttc

catc

ccag

tctta

gtga

gaag

ctaa

acta

acttc

tggg

cctc

aO

atta

cagc

agat

ta

313

3681604

LOC728

NO

tgcc

atag

accc

tcac

gtgt

ttgttg

catta

attg

gata

attc

aaaa

tata

aagt

atta

tcca

gtttc

agga

taat

atta

agat

ctaa

acca

atga

atgc

tcta

tgaa

138

aagt

tgta

gatta

actg

atcc

ctta

aaac

taaa

aaca

gcgt

cttc

ataa

gcttc

tact

gggg

gcag

ctac

cact

ttcttc

atca

cattt

ctta

tcct

caat

agct

gtg

ggca

atgc

caaa

atag

c

314

2410882

ATPAF

NO

gttg

gccc

ttcac

ctag

ttgac

tcag

ccct

cgat

agtc

taga

gccc

accc

cctc

ctca

ggaa

ctca

agag

ctca

gcat

ttata

atga

gcag

ttggt

aatg

agtt

1gc

ccta

tgtg

cttg

tcgc

aagc

agtc

acag

agat

gagc

ccta

ttact

tgat

attc

agga

acaa

aggt

acct

gaac

attc

tgat

aatta

tctc

agca

tact

tgag

gttt

ccttt

tttaa

gtgt

tcga

ggtta

taac

aaga

gaca

gcca

agga

ccta

caag

acag

ttgac

ttgat

tttgc

acag

tgta

acag

cgca

gttg

cattc

tggc

cact

ttgac

ctta

tagc

tccc

aaat

gatg

agttt

gtca

tcttt

atga

actc

atga

cagg

ataa

taag

cttg

aaga

cctg

ctgt

agtta

gata

tggg

cttta

atcc

ttccc

aggc

acca

gtca

gctg

aaca

aaag

cata

agcc

aaac

atcc

tgttt

aaac

tgta

gaat

aacc

agat

attc

ccat

cagg

ttaaa

gact

tcat

ctag

atga

tgcc

ccc

caga

gatg

ccttt

agtg

taag

tagc

tggc

ttggg

gtat

cagc

aaat

ttcag

gtat

agtta

gata

aaca

ggta

cagg

gcct

gcat

acta

ttaaa

ccat

agttt

gtg

gcac

ccgc

ttttc

ta

315

2821

250

CA

STY

ES

aggg

ccag

atga

tgct

atag

acgc

cttg

tcat

ctga

cttc

acct

gtgg

gtcg

ccta

cagc

tgct

ggaa

ag31

631

3407

0PR

KD

CY

ES

gattg

gagc

aatg

atgt

aaga

gctg

aact

agca

aaaa

cccc

tgta

317

3888

286

NO

agct

ccttg

ttaca

tggg

cctg

ttaac

atgg

cagc

tttgt

ctat

aagc

aaac

ccag

gaga

gaaa

gaca

tagc

agag

atgg

atgt

ttgaa

gtct

atac

cttc

cac

cccc

tttaa

agag

aaag

taac

acca

ctcc

ttttc

tgtg

tccc

ttggg

gaca

ctac

ctcc

atgt

ctgg

tcac

atgg

ctgg

acttt

acag

caga

taag

cata

ctgt

ggc

ctga

gacc

atga

ttgta

tgct

ttcct

tctg

ctga

ccttt

acaa

tccc

tcaa

taaa

ttgag

ctaa

caca

ggga

agct

ttttta

ccaa

ataa

ctgt

gttg

catc

atcc

tcca

gtttg

cctg

gtgt

cctta

atca

atgg

aagg

ggaa

taag

caaa

ctga

gtttt

ctta

cacc

ttttg

agta

tagt

gtttt

tgcc

atca

taga

tgtg

gctc

ctca

taa

ttctc

caac

tttta

tatta

aaaa

acca

aaac

ctca

aaaa

ttgta

gttc

atgt

cagt

cagt

gatg

actc

atct

taga

agta

ttttg

tttttg

gatg

tgtg

aatg

tgca

tag

ttctta

aagt

ccaa

cattc

atgt

aata

agac

atct

tgca

tata

acaa

tgac

cctta

cgtc

taag

atgt

taaa

taga

tcct

aagc

ctgg

tata

acttt

attc

aagt

atcc

ttattt

gccc

ctaa

aatg

tcttt

aata

caca

ttact

tggg

ttattt

cttg

aatg

aaca

taca

ggta

tccc

aattt

ctgt

tttta

agag

aatg

gggt

cttg

ctct

gtca

ccc

aggc

tgga

gtgc

agtg

gtgc

agtc

atgg

ctta

ctgc

atcc

atga

tcct

cctg

cctc

agcc

tccc

aagt

agat

ggga

ctga

aagc

acac

actg

ccat

ccct

ggct

aatg

ttttc

atat

tttgt

agag

ttgca

gcct

tgct

acgt

gacc

cagg

ctgg

agtg

tagt

agct

attc

acag

gcat

gattg

cttg

aaac

tcat

ggct

tcaa

ggga

aact

ccca

318

3919790

—NO

gcag

ggag

tgca

gaaa

ccttg

gaga

aagt

gaga

gtttt

ccag

ccaa

aggg

aact

ttgtg

tttcc

ctgg

ctgg

gact

cttg

ggga

tcttt

ttcag

gtttt

ctgc

agt

ttttc

tgaa

ttgag

cttta

aggc

aact

ggat

ggat

tttga

act

319

3948965

—NO

ctta

gctg

ttcca

gcgg

ccca

tgttt

aaaa

gaat

gtgc

ttcttt

ttcca

agta

tttct

gccg

cttg

catg

cact

gagc

ttcttt

ggaa

agga

gcac

catg

cagg

cata

ttttc

caga

cagg

accg

gattt

gctc

gtta

ctca

ga

320

2738676

—NO

ctga

gacc

tgaa

gcac

gaga

gcca

agtg

tgta

agca

agtc

gatg

ggat

tggg

aaga

agttt

aggc

tgct

aaaa

aattt

ttaca

taaa

gcttg

ataa

gagg

gga

tattg

catg

tgaa

ataa

acag

aaat

tcag

taaa

tatg

gtgg

aagt

gcag

gattt

aggg

gatg

gaaa

aaaa

tact

agttt

caaa

aattg

aggc

taga

agtg

aag

gtag

gggc

caga

ttatg

aaaa

gcct

tgta

agca

atgc

taag

aaac

aata

gatg

tcag

aagg

acat

gcca

ccat

ctaa

aaag

cagt

cttg

agaa

caag

taat

tgga

taaa

ggtg

acct

gact

aggt

atttg

tttttt

taag

taaa

ttgtg

ttaat

tttgt

tagg

tgta

aaaa

tggc

atta

gggt

catg

ttggg

gaaa

aaag

aatc

tctt

tctta

caga

tgaa

atta

catg

gtct

ctga

gact

gcttc

caaa

aa

321

2929182

—NO

tggg

tgta

aaca

ttgat

gatc

cttc

taat

actc

tgtc

ctct

taat

ttctc

taag

ttctc

tttct

agtg

atct

tgtc

tccc

agtg

tggt

gggt

atat

tctg

gcta

gacc

aggt

cattg

tttat

ggtg

gcag

cccc

tctg

tcat

ctga

attta

agcg

tccc

atttt

ttcgg

tact

agca

tggc

tcac

tgc

322

3004581

—NO

gcaa

atgt

tttaa

tggg

ccct

ccta

cctta

cctg

acat

aaga

taat

tcat

acta

gaaa

gaat

acct

acaa

atgt

gaag

aatg

tggc

aaaa

gcttt

agtg

tattc

tcaa

ccttt

acta

atca

taaa

gcaa

ttaat

actg

gaga

gaaa

tctta

caaa

tatg

ttgaa

tgtg

acaa

tgttt

ttaac

tagg

ctgc

aact

cttg

ctg

323

3300811

C10orf4

YES

tttgg

attta

ggtg

gcga

gtag

aaaa

a324

3426258

—NO

atgg

agat

taag

cagg

aact

tcaa

gaaa

gcca

agct

cttc

ttggt

agca

cacc

agag

tctg

aagg

325

3645807

—NO

agtg

gaat

ctct

gaaa

ctca

ggtg

tggc

atca

acaa

ag326

3976960

—NO

caaa

tccc

gggt

ggca

gcca

taat

cccc

aaag

atga

cccc

cacc

ccaa

gattc

caaa

gaag

ctag

tggt

ggtg

gaag

caaa

agga

atgc

agca

aggt

cag

ggttt

cattg

tcca

agcc

ggcc

tgac

acct

gccg

ccct

gccc

ttgcc

cagt

gcac

accc

taga

ccct

gggc

cggc

ctcc

atgc

agct

ggag

gcca

gaa

gaca

gcaa

ccca

tatc

tttgc

accc

tcct

ccat

gccc

catg

gcct

gcct

gccc

agaa

agat

gcca

ccttc

acag

agcc

agtg

ctgt

cgtc

tata

tcat

tt

327

3981

121

OG

TN

Occ

gtcg

ccgc

cattt

caag

accg

tact

ag

328

2391

399

CPS

F3L

NO

gtat

gcac

cggc

ttatg

aacc

cacc

aggc

tctg

tccg

agcg

gcat

tgaa

atgg

ccag

agtg

ggac

aggc

tggt

gccc

tcag

agcg

cttg

gagc

ggcc

agag

actc

gctg

gagc

tccc

gggg

tgttg

ccgg

gcag

ggag

gcag

gggc

tgga

gggg

agat

gggc

cagc

tctg

gagg

gtgc

ctgg

ttctg

ggtg

tggg

tca

ggga

agaa

gtga

aggt

taaa

tcag

cgag

tgac

aggt

gaaa

ttcca

tttct

gaca

aaga

ttatg

ggttt

gtct

gtgt

ctca

ctcg

aatc

tctg

gg

329

2748

879

GU

CY

lY

EJ

tgcg

aattg

gact

gcac

tctg

gatc

agttt

ttgct

ggcg

tcgt

tgga

gtta

aaat

gccc

cgtta

ctgt

ctttt

tgga

aaca

atgt

cact

ctgg

ctaa

caaa

tttga

gA

3tc

ctgc

agtg

tacc

acga

aaaa

tcaa

tg

330

3063

716

___

NO

gtga

gtgg

ttaga

gaac

aatg

gcaa

acaa

aggg

cgag

gcgt

ttaag

cttc

tgta

gaga

gg33

133

6187

4T

RIM

66N

Otg

ggct

tccg

tgat

cccg

ttttc

tagt

ttggg

gtaa

ctga

gtct

tgaa

tgct

ttact

agtc

cggc

aatc

tttgg

actta

ggct

tctg

ccct

ttgag

actc

acat

gact

ttctg

gtttg

gggt

ctgg

tcat

ttccc

tttca

atttt

tgaa

tctc

cttc

tctg

ttcag

ttggc

ttggc

aaag

tacc

ctct

gttc

tcat

g

332

2812

780

NO

tctg

gaat

gaaa

cagc

gtaa

tgag

atga

gccc

tga

333

3065

419

—N

Oct

acaa

ggat

actc

aggt

caga

aagg

ccca

ggag

tacc

tacc

tcat

tcag

caac

agtc

cagt

caaa

atct

tcct

cccc

gaca

atgg

ccta

tgac

cagc

ctgt

tcta

caca

ttcct

ctct

gg

334

3077

669

NO

aaga

gccc

ttctc

aatg

gctta

accc

atag

agcc

c33

536

5296

1__

_N

Oaa

gcgg

aggt

tgga

ggaa

gccg

tgat

tgta

cc33

628

9567

8SI

RT

5N

Oaa

agca

gccg

tgga

gaca

acca

tctt

O33

729

7805

7N

Oct

gtgt

tgtc

tcag

tcaa

gcct

agaa

ctga

agct

acct

gaca

tcaa

gcca

attg

tcca

ggac

cagc

atttc

cagc

acttc

cagt

tgtc

cata

tctg

cact

tcca

gga

gtaa

acag

gca

338

3595

946

RN

FlIl

YE

Sca

aggc

cact

tcat

catc

aagc

ttctg

cctg

cccg

cattc

tcat

ggaa

accc

ccct

cctc

agac

tcag

cctc

cgcc

tcaa

gtgg

atta

tgtta

ttcct

catc

ctgt

acat

gcttt

ccat

tctc

aaat

atct

tctc

atgc

aaca

tctc

atcc

tgtg

gcac

cccc

acca

ccaa

ctca

ctta

gcca

gtac

agct

gcac

caat

ccct

cagc

atct

tcc

tcct

acac

acca

gcca

atttc

gcac

cata

ttcca

gc

339

3628

693

HE

RC

lY

ES

tata

ggaa

atca

tcag

gagc

caag

tgtg

tttat

cagc

tgcg

ggga

caca

tcac

tcct

gttc

ggac

tgttg

ccttt

agttc

tgat

gggt

tggc

cctg

340

3734

777

MR

PS7

NO

gtga

gcta

ctgc

cacg

ctga

aaac

tacc

tgtg

ggtta

agga

tgta

gttc

ctttg

taag

ggtg

ggca

ggcc

tcgt

aaga

aaga

tgta

gcag

cata

ttcac

tatc

cgtta

atcc

ttcttt

ctttg

aggc

tgga

acttg

ctct

ctct

gccc

ctat

ttcct

tgta

aaga

ggga

gcac

attg

acttg

ggaa

tttcc

tcca

ggaa

actc

aggg

ctg

tttt

341

2806

269

DN

AJC

YE

Sac

agag

ctgg

atga

ctat

ggcc

aattt

ggag

aaag

ag2

134

228

4912

1D

NA

H5

YE

Sat

gaat

ccca

aagc

gatta

ctgc

ccca

caga

tgttt

ggtc

ggct

ggac

gttg

ccac

aaat

gact

ggac

tgat

ggga

tattt

tcta

cgct

ttgga

gga

343

3012

989

___

NO

tctta

ttcttg

gcca

cggg

acca

accc

tcac

aggg

gcac

tcta

tgca

gaag

cttc

cttc

ctaa

attg

gaac

tccc

acttt

gacc

actc

tcct

tt34

431

8465

5N

Ottg

caag

gccc

acac

cacg

tggc

tgag

aagt

caac

tact

acaa

gttta

tcac

ctgc

agcg

tcca

aggc

ttcct

gaaa

agca

gtct

aaca

gcaa

aaga

aaag

ctta

tatta

aata

aata

gtta

aata

ttaaa

ccttc

aaaa

gaaa

gact

cgac

acaa

tgac

acaa

agca

cattc

tgga

ggtc

ctc

345

2428

776

RSB

Nl

NO

gctg

ccca

agat

gttg

gaac

acca

tgtg

caat

aaag

ggct

tcgt

cttg

gattt

tggc

ctta

ttacc

acaa

ccag

346

2502

833

DB

IY

ES

acgg

cccg

ggat

gttg

gact

tcac

gggc

aagg

ccaa

gt34

726

0858

9_-

_Y

ES

ttcca

ttgat

gaat

tgga

taat

gctg

ag34

827

8161

0_-

_N

Oct

taca

ggag

aaat

cgaa

acac

agct

gcta

c34

928

1098

9_-

_N

Otta

gagt

ttatg

gacc

ttgct

cttg

gtta

350

2489

148

—N

Occ

tctg

ccttc

gctc

gcgc

cgct

ctcc

ttcag

tctc

ccca

gggc

ctgt

ttcat

ggat

aggg

tccc

cttg

cccg

cgtg

aaag

tctc

attc

ctc

351

3239

162

—N

Occ

actg

gcta

ataa

gcag

gtct

ttattg

agtg

ccca

acac

tgag

tttag

tcac

aggt

gctta

ttctg

gata

atta

atct

cagt

agat

taac

cttc

ttcag

aatg

acc

atgt

atat

caga

cttc

tctta

tccc

caat

tctg

ggtc

ctta

ttaac

ctct

tcca

gggc

taag

tattt

accc

ttcca

taaa

tcgg

atgt

tttct

taag

cattt

tttct

cctg

tca

tcac

tgaa

actc

cagc

ctag

ttcttc

acttg

tatg

caat

tttct

tgta

accc

tgtc

tctc

gtttt

ggttt

attg

tcca

tatg

ccta

ttgag

tgct

tttcc

agttg

352

3573

019

POM

T2

YE

Sct

gata

ggtc

ttgct

ggct

acct

gagt

ggat

atga

tggt

acct

ttttg

ttcca

gaag

cctg

ggga

taaa

tatg

agca

tcac

agct

acat

ggga

atg

353

3937

196

DG

CR

8Y

ES

ttgtg

cccc

caaa

aaga

ggcg

aaca

gagg

aaaa

atat

ggcg

gaga

cagc

gacc

atcc

gtcc

gatg

gaga

gaca

agtg

tgca

gccg

atga

tgac

caag

a35

431

5433

1N

DR

Gl

NO

tgct

gggc

gtca

agct

tgca

taat

gccg

tact

ttgag

ggcg

gttg

tcac

aagt

atca

caaa

atgg

gtgg

ctta

aagc

aaca

gata

tttat

tccc

tttta

gttc

tgg

aagc

taaa

agtc

cgaa

atca

aggt

gtgg

gcag

ggcc

gtgc

tccc

tctg

aagg

tgct

aggg

gaga

atgc

tgcc

tgcc

tcttc

cagc

ttctg

gtgg

ctgc

tgg

ccac

acttg

gttc

acct

tagc

tagt

agac

acat

cact

ccag

tctc

tgcc

tcca

tcct

cact

cagc

actc

tccc

gattg

tatc

tctg

cgtc

tatg

tcca

aattt

ccttc

VOttc

tttta

ataa

catc

agcc

gtta

gcttt

aggg

cccg

ctct

aatc

caat

atga

cctc

atct

taac

ttgat

tttac

ctgc

aaag

accc

tattt

ccaa

gtat

agcc

acag

tgat

aggt

actg

gggt

tagg

acttc

agta

tgtc

tattt

tggg

gaca

caat

tcaa

ccac

aacc

taca

gcaa

aggg

tagg

tggc

ctga

ctga

ggtg

gggt

ggcc

gattt

gatg

gtag

atcc

agaa

acag

aact

cact

tagg

cctg

attc

tgga

gact

tcca

cagc

gtca

gtct

aatg

tgct

gagt

gccc

cgcc

tgga

ggaa

aaat

tcgg

gcat

c

355

3697

772

PHL

PPY

ES

tccc

agcg

aatc

agta

ccgt

ggat

ctct

cgtg

ttaca

gcct

cgag

gagg

ttcct

gagc

atct

cttc

tata

gtca

agat

atta

ccta

cctc

aact

tgcg

acac

aac

Lttc

atgc

agtta

gaaa

gacc

cgga

ggcc

tcga

taca

ctct

acaa

356

2611

934

SLC

6A6

YE

Sgc

tatg

acct

cgct

gggg

agct

acaa

caag

t35

731

2780

7N

Oca

agga

agcg

agtc

tccg

tgac

acgt

ggta

caat

atca

tgca

gtac

acac

ggaa

ccag

aacc

aaga

agaa

atgg

ctgg

aaaa

gatg

aaag

aaaa

aaaa

agttg

atat

agtc

tcaa

atgt

agtg

aaaa

aaca

tcaa

ctta

taga

ttcaa

aaag

ttcat

aaac

ccct

cata

aaaa

taaa

tgta

aaga

aaac

ccta

cctg

gaca

catc

atag

tcat

cata

caga

gcaa

atttt

gtgc

attc

acag

gtaa

caaa

gata

tgaa

cgac

agct

gact

caaa

acaa

tgga

ggct

cagg

atgt

gtga

aatg

gtga

aaga

aagc

tgttg

actc

acta

ttcac

actc

attg

agaa

tatc

cttta

aaaa

tagt

aagt

gaag

acgt

tgtg

gcag

gttg

aact

ttcc

358

3909

039

SPA

TA

NO

aggg

ctac

atca

accg

acct

ttcgg

gtttc

acgg

tgaa

gaag

tact

aacg

cattg

atct

caga

ggcg

gagg

cctg

cact

tgac

catg

tagg

tggc

agag

at2

cgtg

ggct

ggct

gtgt

ccac

gtgg

gagt

tcac

ttagc

gact

caga

tatc

tcaa

ccaa

tggc

tgct

ttgttg

tctg

acaa

ggga

gaag

gtgg

cact

tccg

ttca

gattc

atttt

gcta

atct

ctcc

actc

cctg

ttcag

ttggt

tcttt

ttttg

gggt

tttgt

tttgt

tttgt

tttgt

tgttt

tgttt

tttcc

tttaa

agag

gattt

ctgt

ctct

ggga

ccct

cgct

gcac

ctac

ccct

ccca

ttgca

aagc

caac

ttgga

ctgg

gaag

ggcc

cttc

aggt

cacc

aaac

atcc

acct

ggag

cggc

gagc

taga

ggcc

tgtt

ggct

tgtg

aaat

gagc

cctc

ctgc

caca

cggg

gcct

ctcc

caaa

ggct

catc

ccttg

gccg

cccc

cttc

ctaa

acac

aagg

atcc

ccag

ctgg

actc

ccca

cccc

ctgg

cttc

ccca

cctc

tcca

ggtg

tcaa

aggt

gaac

cgag

tcca

gtat

tagc

tgaa

tgtc

atttc

gtac

acca

cagc

tcag

tcag

ccca

tggc

cttc

gtga

acttt

gctc

c

359

2412620

NRDl

NO

gtttc

tttga

ggaa

cgca

gcct

gaa

360

3220615

KIAA03

YES

gacc

ctaa

acta

ctgt

caat

ggca

tattc

ag68

361

3521230

—NO

tgct

gctg

acat

cacg

ggcc

ctgg

gtt

362

2327492

SNHG3

NO

gaca

atct

ttggc

agac

ttgga

gcaa

aaga

ttgag

gtgc

atttc

atgc

ctcc

tt363

3557645

AP1G2

YES

tgtc

aaca

ttcttg

gtcg

cttc

ctac

tcaa

cagt

gaca

gga

364

3709227

—NO

tgcc

gtcc

tcag

tgaa

tcac

agca

gcttc

aaag

gact

caac

tggc

aaga

tttcc

caca

g

VO365

4021348

ZDHHC

NO

gaga

gcaa

gtaa

gctg

tccc

tttta

actg

tttttc

tttgg

tcttt

agtc

accc

agttg

caca

ctgg

cattt

tcttg

ctgc

aagc

tttttt

aaat

ttctg

aact

caag

gca

gtgg

caga

agat

gtca

gtca

cctc

tgat

aact

gg

366

3030

989

ZN

F862

NO

aggg

cttg

accc

tgcc

taga

tcct

cctta

ccaa

gaaa

gggc

tgaa

aaga

gagg

gcat

ctgg

catg

ctttt

tgcc

acttc

tgttt

ctag

gtta

tgta

cttc

atgg

aat

atct

gggc

attg

ctta

gaaa

cctg

tgtc

ataa

attg

gcttt

gggc

aaga

ggct

ttgag

ttgga

agaa

aagg

tgga

aaga

aagt

gcttg

gggg

cgga

gttc

aggg

atttg

acgg

gattg

ccag

cgct

tcca

ggcc

gtgt

catc

caag

acca

gtgt

ggttg

tggg

caca

ttagc

ttgga

gaca

gtgg

cagc

ctct

tggg

acta

acat

cttt

367

3035657

—NO

agtc

cggt

ggct

taga

tgac

aaat

ggag

gtag

agga

cgca

ttctc

gcct

gtta

tttcg

atttt

tttct

ctcc

tcac

cctg

accg

tcac

gttc

tcac

ctttt

ccac

ctc

aatc

ccca

gtca

cact

agct

tccc

agga

ttaaa

atgg

tctc

t

368

3626930

—NO

tgct

ttcac

ttaag

gcag

ggct

gttg

agtc

ggtg

aggg

gatg

aggg

catc

tcaa

aaga

aggc

tggc

tttca

ggat

tgca

caga

gatg

ttcct

gctc

ccag

caga

ctgg

ggta

aaat

ttcct

ggga

atga

gggc

atttc

tga

369

3091396

—NO

caag

tgag

agtg

atttt

gtta

catg

ggat

acat

tgca

tagt

agta

aagt

ctgg

gcttg

tagt

gcaa

ccat

cacc

cgaa

ta370

3323928

—NO

cagt

gcat

cccg

gaaa

aaag

agag

caaa

371

3326853

TRIM44

YES

tggc

caag

agga

agtg

tccg

gacc

atgg

gcttg

atttg

agta

ccta

ttgcc

ag372

3402333

—NO

caaa

gtcc

tttgc

aagt

ctca

ccct

taag

cgcg

tggg

gact

gtgt

373

3796317

—NO

tcac

gttg

ctgg

ctac

cctc

atat

gtgt

gatg

actg

ttagt

tgta

caat

taca

tttaa

gaaa

gagg

atta

cattg

ctag

ctgg

aattt

cttc

tact

atta

taaa

aata

gaa

ctgt

tttac

caac

aagt

ctct

tctc

cgag

tggg

acttg

atgg

taac

tata

actg

ggat

aggg

caaa

tcaa

cgtc

atgg

gtcc

acag

gtttt

gcttt

aa

374

4020467

—NO

tccc

aaca

agttg

aacc

ttgcg

ttacg

ataa

aagc

agat

gtgg

catc

caat

ccta

ccac

ccag

caaa

gaga

aacc

ccag

gcat

tcaa

ctgc

agc

375

3180404

—NO

catc

gctg

tgtg

catc

taac

tcttg

attc

acgg

tctg

accg

acgc

cttg

gtttc

tgga

gaac

tgcc

ctcg

tttat

ggaa

gagt

cact

gtca

tcag

gagc

catc

ccag

ggag

aggc

tcag

tggg

aagt

gtaa

aggt

ggag

caag

taaa

ccgg

ctcc

agaa

gaga

aggc

gaag

aagg

acta

tttct

gttta

gattt

gctta

accg

cattt

tcac

tttct

tggg

aacc

cctg

atgg

agttc

aagg

tcat

agaa

gaga

agaa

atca

gaca

ctgc

taca

ggac

tcttg

ctct

tggt

t

376

3781848

NO

gagg

aagt

gtct

ggtc

cggt

ccct

agag

catg

gcag

gtat

gcac

tcaa

tgct

377

3868844

KLKIl

YES

tcaa

ggca

ttatc

tcct

gggg

ccag

gatc

cgtg

tgcg

atca

cccg

aaag

cctg

gtgt

ctac

acga

378

2396267

___

NO

tggg

gacg

gcaa

cacc

gcgc

tgca

agtc

gtta

tcat

tccg

379

2862752

GFM2

YES

tggt

ggat

gtag

taat

gaaa

gaaa

a380

3869672

___

NO

ggag

ttgca

tcct

tgct

tgac

taaa

atgg

aagc

cgta

ttgat

tttga

aatg

aaaa

gcttc

atga

tgta

gcat

ctgg

acttt

cact

gtcc

381

3876038

PLCB4

NO

taag

gattt

caac

acac

gtaa

ggcc

atgt

ttctg

atgt

tata

g382

3879228

—NO

gggg

aggg

acat

gact

tcct

gtta

cggg

atga

ggaa

gtag

aggt

tcat

ggag

ga383

2399914

___

NO

ttaga

cttg

aaag

aacc

tcgt

tcac

ctgc

caca

tgct

atcc

tagg

gaat

taat

agct

tccc

atgt

ggac

actc

actc

tatg

t384

3142073

—NO

gggg

aacg

aagc

ctga

caac

tcct

aagt

ttctg

gcttc

taca

acca

tttag

tgaa

ggttt

catta

atgg

cagg

cagg

agta

cagt

tttag

aagg

tctg

gact

ggag

agac

atttg

gggg

aatc

atcc

gtga

gtat

cgag

agtta

aaga

catg

ccag

gaat

agtg

tata

caat

taaa

atag

acag

gggc

ttggg

aaat

gcca

gttc

gO

caga

tata

tattt

gtca

taag

tgaa

ctaa

agaa

aagg

tata

tggt

tgga

tgag

ctta

aacc

cagc

atg

Ul

385

3777286

ARHGA

NO

cgca

gttc

atga

cttg

tacc

agtg

aagg

tagc

aagg

tctg

tgtg

ttggt

gatg

aattt

gcag

ggga

tcag

gctg

aaga

aaca

agac

ttggg

agag

agga

tgt

P28

gaga

ccttt

ttatg

acat

gcat

agag

ttggc

acct

cagc

ctttg

catg

gtag

ggag

ctag

ctga

aggc

tacc

tcca

tgac

agat

gtac

acttt

gaaa

agac

aggc

cggg

tgcg

gtgg

ctca

cgtc

tgta

atcc

cagc

atttt

ggga

ggct

gagg

tggg

caaa

tcac

ttgaa

gtca

ggag

ttaga

gatc

agcc

tggc

caac

aca

gtga

aacc

tggt

ctct

acta

aaaa

aaat

aaaa

taat

tagc

cagg

catg

gtgg

cgca

cacc

tgta

atcc

caac

tattc

ggga

ggct

gagg

caga

agaa

ttgct

tgaa

cacg

ggag

gcgg

aagt

tgca

gtga

gctg

agat

ggca

ccac

cgca

ctcc

agcc

tggg

cgac

agat

caag

actc

catc

tcaa

aata

aagg

aaga

taca

gcta

atct

atat

ttcttt

cacc

agag

atca

ccac

cact

aaca

attc

atac

tggt

cgttt

ttccc

tgaa

tgttt

tacc

tatg

tagg

aaaa

tttta

catc

ccaa

ttttta

attt

aaca

ctat

gaaa

agca

tttct

tttta

taat

aaag

acac

tcta

ttagt

atac

ttttg

atgg

cttc

aaaa

ctac

ttttg

tata

gatg

caaa

atta

aaat

atca

aattg

tttct

tttgt

ttgttt

gtttt

tttgt

tttttt

tttga

gaca

gagt

ctca

ctct

gtcg

ccca

ggct

aaag

caca

gtgg

catg

atct

cggc

tcac

tgca

agct

tttcc

tccc

aggt

taaa

gtga

ttctc

atgc

cgca

gcct

cccg

agaa

gctg

ggac

taca

ggtg

tgca

ccac

cacc

cccg

gcta

atttt

ttgta

ttttta

caaa

acac

aaag

agag

acgg

ggttt

cacc

atgt

tggg

cagg

ctgg

tctc

aaac

tcct

gacc

tcag

gtga

tccg

cctg

cctc

agcc

tccc

aaag

tgct

ggg

386

3851492

NO

tttttt

acgg

attc

agtg

atct

ggac

gggc

acat

acta

ccat

387

2712928

NO

gtga

gtaa

acca

tggc

gtgt

ttgttg

gcca

aaag

ccgc

aagt

ctttg

aaaa

ggtg

aatc

atca

ctttt

ccat

tta388

3060349

NO

ctct

ggag

gcttc

ttgtc

agta

ctag

aaac

taat

acttg

gtga

atat

ccttt

tctg

cttc

catta

ccttg

tatg

aaac

tggt

tcca

tttat

acac

tgag

atta

gaag

cattc

ataa

gtga

tgcg

gcac

caca

aaca

caga

agat

caaa

ctac

tcac

agtg

tgga

gaac

catg

tcttt

tata

agtg

tgat

gtgc

ctaa

aacc

atca

tc

389

3504

762

ZD

HH

CY

ES

aaac

ccca

aaac

tgtc

cagg

catg

g20

390

3543

824

—N

Oag

tcttt

tata

agtg

ttggc

tatc

atttt

ttctc

atct

atttc

cttg

cttc

tggt

tttgc

acac

tttac

catc

caca

ctgc

catc

agag

tgat

caca

cctc

tcttc

agta

gctc

ccat

catc

tact

gcat

aaag

ctga

gact

gtta

gcta

gact

gtta

ggca

ccttt

ccca

cacg

atct

ggct

ctgc

ccca

cttc

ccag

cctc

agcc

caca

tggc

taa

acaa

391

3781

951

LA

MA

3Y

ES

gattt

gggc

ttacc

acct

actg

acca

cctc

cagg

cctc

atttg

gattt

caga

ccttt

caac

ccag

tggc

atat

tatta

gatc

atca

gac

392

3216

926

—N

Oaa

cact

gatc

tcca

cgag

caca

atca

tcca

aacg

gaga

tggg

aacc

cctg

ttcta

actc

tctc

agag

gcct

gaa

393

3448

246

—N

Oct

ctttg

gtat

atta

ttgca

gatg

ttgtta

tttca

cagt

tagg

taaa

ttaga

cata

aaaa

ggtc

aaac

gact

tgaa

cgtg

ctac

cata

aaag

gtca

gtga

taaa

gcca

gaag

tcat

ttctc

agtg

tcca

tcat

aagc

cacc

394

2693

224

OSB

PLY

ES

ggag

atgg

ctgg

gttta

tcat

aaac

cact

ttgga

aaat

aattc

caac

aaca

caac

cagc

agag

tga

11

395

2672926

SMARC

YE

Sta

tgttc

atgc

ggat

gctc

ctac

caat

aaaa

cact

ggct

gggc

tggt

ggtg

cagc

ttcttc

agttc

cagg

aaga

tgcc

tttgg

gaag

catg

tcac

caac

ccgg

Cl

cctt

396

2914136

—N

Occ

atcc

gttc

tttta

gctg

acttg

aatg

actc

taat

gcag

tggg

ttgca

ggttt

ggct

actta

ccta

tgta

ctct

gtaa

acat

ccag

aggc

ccag

ggat

attc

tga

gcca

ctgt

gtgt

gaat

ggag

tttgg

ccat

ctgt

agat

ttccg

cagt

ctct

ccag

gtga

tcgc

actg

tgca

gcct

cattg

ctc

397

3210858

—N

Ottt

gctc

tgaa

aggc

agttt

ctgt

atag

gttc

ctcc

gagt

gaag

atca

gaat

gtta

tcag

acac

tggc

tgta

gctc

agat

gaca

398

3853401

AKAP8

YE

Sac

ttgga

actc

tggg

acaa

atag

agL

399

3605225

—N

Otg

gacc

catc

tcag

cagt

gctc

aaac

caat

gccc

aaac

tctc

ctgc

ttagg

acac

ttctc

cact

ggcc

accc

tgag

gcca

ccac

acct

cact

ggcc

actc

ctcc

tcta

tcttc

tctg

ctgg

ctct

tcct

cctc

tatg

gcca

ccta

aagg

atgg

gtgt

taca

cact

caat

cct

400

2377461

—N

Otg

gagt

tggc

cttg

ttaac

tatta

aaca

caaa

agca

tgtg

atag

ttacc

tgag

agat

ccat

gcag

ggga

gagt

ccag

ggga

aggt

gact

gatc

actg

cttc

cca

gggg

gagg

caga

aaat

gcttc

ctgg

agga

gatg

atgg

gtgg

atta

agga

agat

gagt

tgag

cagg

agttg

tagc

tacc

agcc

aggg

agga

aggg

tattc

agag

caga

ggaa

gcaa

ggtg

agca

aagg

cacc

aaga

tgtg

acac

tact

ggac

tgcc

aagc

ta

401

2934549

—N

Ogt

gtgc

tact

ggct

tatg

gctg

atac

gtaa

gaga

atct

catc

tatc

tcta

aatg

ttctg

cctta

agcc

gcac

aaag

ga402

3185031

—N

Otg

gcac

atgt

ggat

tcta

tacc

ttaat

taaa

gcca

ctcc

ctta

cata

caca

cattt

aggt

atcg

ccag

actc

gcct

gatg

agga

ataa

ttattc

tttcc

tcca

tattt

ctta

actc

ctgt

ctttt

ccat

gaaa

cggc

ttggc

atta

aact

ccttc

ccag

a

403

3560964

—N

Ogt

aatg

tggc

ggtc

aaaa

ccgg

cgct

ggaa

ccac

ggga

catg

tt404

2732616

MRPLl

YE

Saa

cgtg

gagc

cattt

acca

gtgt

tctta

gtttg

ccat

accc

atttg

cttc

cgaa

atca

ataa

agttg

ctgt

attta

caga

g405

3150536

—N

Ogc

cact

cattc

atgg

ttgttc

tatg

ttcca

tgaa

ctct

aata

gccc

aact

tata

catg

gcac

tcca

aggg

gatg

cttc

agcc

agaa

agta

aagg

gctg

aaaa

agta

gaac

aata

caaa

agcc

ctcg

tgtg

gtgg

gaac

tgtg

gcct

cact

ctta

cttg

tcct

tcca

ttcaa

aaca

gtttg

gcac

ctttc

catg

acga

ggat

ctct

acag

gtag

gtta

406

3774

169

NO

atcg

ctgt

acca

ttctg

gggc

actg

gaga

tggc

agct

gaga

agca

gaga

agct

ggag

acct

gaag

cctc

cacc

cttg

gctg

tggc

tgcc

gaga

gagg

cccc

tgca

gagg

gagc

ccca

ggcc

acac

ccag

acac

caca

gcca

gctc

acag

tgcg

gcca

gagg

gcac

aggc

tgct

tggg

gggt

gagg

gtcc

ccat

tcct

gcca

cctc

tcac

agac

catg

accc

acag

ggct

gggg

gcttc

ccct

ggga

gaaa

gtcc

ttccc

tccc

catg

gccc

agcc

ctgg

ggaa

agaa

agca

gag

acta

actc

aggg

actg

cagt

aggc

tgag

gaca

aggg

aggt

gggc

ttggg

gtga

aggc

cccc

cctc

actc

gcag

agaa

ggga

cact

accg

gcag

taga

ggac

aggg

aggc

agga

cgac

ggca

gtta

gaga

cgag

gcgt

ttcag

gtga

actg

tatg

tagt

gtta

ctcc

ggac

gtga

gcat

ggcc

tggg

tcag

tcga

atga

aatg

agct

gggc

ctcg

ctgc

cctg

tgcc

ggcg

gccc

ctgt

gcct

gcgg

ttgct

gggc

cacg

gggg

gctg

ctgc

tggg

gggg

accg

ccag

aggg

tgcc

atct

gtgc

agga

ggaa

agca

ggca

tggc

cctg

gtcc

tccc

ttccc

cagc

ccag

ggag

gaag

gcttt

tgtc

ccag

caga

gcca

caga

ccca

caag

tgc

ttgta

atcc

atgt

ccac

ggac

tgca

gctc

atg

407

2987860

NO

cccg

tgttt

cgtg

taca

acat

atga

taca

tgtg

acag

ttgac

aaga

gtgc

ctga

gtct

caga

gcag

gaag

agtta

tcct

gcct

ccac

atgc

attg

aagg

gaat

atat

gtca

cacg

ttact

agcc

aggc

tcag

agga

gaac

acat

ctca

tttac

aagt

tcaa

atct

gaaa

ggga

gaaa

tgtg

ctag

tattt

agtg

gatc

ttgag

gaaa

ctag

ggat

gtgt

tacc

catc

tgtg

cagg

aaca

ttaga

tcta

gatg

gggc

tctc

ctag

tcaa

aacg

ctga

408

3829652

—NO

atgt

gact

ttaca

accc

tcgg

tgtc

ctcc

tggc

tgct

gggc

ccca

gcct

cctg

actg

ttcag

ctca

caca

cgtg

aacc

taac

acct

gcct

tggt

cccc

tgct

ccat

cttc

taga

caac

tcat

gctg

agga

ccag

ccca

cagg

agga

ggcc

tccg

agttc

tctc

ttgac

gtct

tcac

cttg

acct

tttttg

ccac

cattt

tagt

ctgt

cca

ggc

o409

3900228

C20orf7

YES

gacc

aaag

cctg

tgta

catta

ctac

cact

cgag

acaa

tgag

aaca

tttac

agta

caaa

gattc

cata

tatg

gcag

ctcg

tgttg

ttttta

ttaag

tgga

ttgta

ac4

cttc

tttttg

gaaa

aaaa

gtat

ctaa

ctgc

aaca

caaa

acac

taaa

aatg

gagt

tgat

gtat

tgcc

taaa

atc

410

2858280

—NO

ataa

aata

caaa

ctct

ccaa

caag

acct

tttgg

ccat

cagg

aacg

cagc

a411

3088555

ATP6V

YES

aact

gccc

ggttc

ttcaa

atct

gac

1B2

412

3850502

LOC

147

NO

gact

gtttg

ccaa

tggt

tgta

tttag

taag

atttg

taga

ctct

gtttt

tcttt

tgac

acag

ctgc

aagg

ccaa

cagc

tgtg

caaa

gcca

caag

ttatg

ctaa

gtca

g727

cagt

tatg

ctat

agat

taca

tgac

ctgt

gact

gtat

catta

actg

ctttt

gtttt

gcttc

tgta

agttt

gcct

ataa

aaac

caca

ctca

gtct

ttgttc

aatg

gtca

gctt

ttcag

atac

aaat

ccac

tgag

ccgg

tgta

catc

taaa

taaa

413

3946288

TNRC6

YES

tgtg

gaca

agcg

agcg

atga

atct

cggg

gattt

taat

gata

tcat

gagg

aagg

atcg

atct

gggt

tccg

tcca

ccta

attc

caaa

gaca

tggg

aacc

acag

aB

tagt

gggc

ctta

414

3430162

POLR3

YES

agtc

tggt

tgaa

tattt

agat

gtga

atga

agaa

aatg

attg

taac

attg

cact

gtac

gaac

acac

aatta

ata

B

415

3751732

_--

NO

gaat

atgc

atct

ttaca

agca

tcca

cag

416

2347259

_--

NO

tggc

tgcc

tgac

atta

ttggg

tgct

417

2421262

NO

ctcc

ctgc

ttggc

ttgat

gacc

ttt

418

3886689

PABPC

NO

gtat

ggtc

ttggg

tttct

gctg

agaa

atgg

cttg

tagg

tggg

gggt

taaa

gttc

ctca

cacc

tctc

ctga

acgg

gagg

aagc

tgct

gttc

acca

gtttc

cagt

gIL

ctca

atgc

gggc

aggt

gggg

catc

tgtg

cgttt

ggta

aata

catg

atgt

t

419

3951993

___

NO

ttgag

ccca

gtgg

cggg

actc

cacg

acgt

agac

ctct

ctcc

ttctg

cc420

3966982

NO

ttcct

gctg

acca

acct

aattc

tggt

ttcat

acag

ggca

gcca

ggtg

ccca

ccta

aaag

actg

cact

tctc

aact

tcca

gttg

tttct

atgg

ataa

tggt

tgga

agca

gaaa

ttggg

ttggg

gcttc

caga

taat

cccc

cctc

acag

ggac

tgct

tcaa

gaga

aagg

gatg

ccct

ttggt

tcttt

ctcc

tttcc

actg

cctg

gaat

gtga

tgt

ctga

cact

gtgg

cagc

cata

ctgg

cata

atga

ggcc

aact

ctct

gcca

tgct

aaga

gtgg

caga

gctg

ggaa

ttgaa

aaga

gcct

gcta

gcct

tggg

ttgc

ttccc

cttg

atcg

gctc

atta

cttg

gaa

421

2756

515

MFS

D7

NO

tgag

cgcc

ttgta

gtcc

aggt

tgcc

cgcc

acat

cgat

ggag

gcga

actg

gaac

atct

ggtc

cacc

tgcg

ggcg

gggg

cgaa

aggg

ctcc

ttgcg

ggct

ccg

ggag

cgaa

ttaca

agc

422

3261869

NO

tttttg

tattc

tagt

cgttc

agcc

ccct

cccc

tccc

atct

tcca

gcgc

ttctg

aaca

actc

ctac

tgttc

tcttc

c423

3391839

—NO

ccct

atag

attg

tttga

ggac

ccta

ttaaa

tattg

tata

gcct

ctag

gaat

aagc

ctttc

cattg

acttg

ctgt

gata

aaca

gatc

ttttg

tcag

cgac

tctta

aaat

aca

aaac

agcc

ttggg

cagt

agag

tacc

ac

424

2437406

ClorflO

NO

gcttc

cctg

acct

agac

agtc

ctga

ctga

tggt

ccaa

cctc

aatc

ccac

ttattt

ttggc

tagg

ccttc

ctgg

gagt

cata

aaag

agat

gaat

ccat

tcta

gagg

4tg

caca

gcct

gtct

cttc

cctc

acaa

atgt

cagt

cccc

aagt

cattc

tgat

ccac

cttc

ctaa

tattt

ttgcc

acct

ccaa

cttc

tttca

agat

gaaa

agga

aatg

tag

agaa

gcaa

ggtc

aggg

taga

cact

taat

ccca

ctga

ctgt

cttta

atcc

actc

ttctc

cctc

tcaa

cctg

gatg

atct

ccac

actc

ctat

ccat

actc

agat

aVO OO

cagg

atat

attg

ttccc

ctat

tatg

tgct

aagc

acttt

cata

tccc

ttgcc

ttgct

taat

cttta

cagt

cctg

tgaa

gtag

gaat

tttat

cccc

agct

gagg

aaag

agac

tgag

cgag

accg

acttg

ctca

aggt

caca

cagt

ttttc

acca

gggg

tagc

agtg

ttcac

g

425

2802671

NO

taga

gtta

gagt

cagg

gccc

tggt

ccct

ggtg

ctct

ttcct

ggtc

gcttc

tcat

agcc

agga

cgttg

ctta

catta

gttc

tcaa

cccc

actg

ggac

caat

cattt

tta

ttgcc

aatc

tattt

tggg

gctc

tgttc

tcgt

ggca

ataa

atca

ttcttt

caga

gctc

ccta

tttaa

ccttg

tgag

agcg

tgtg

tgtg

tggt

ggag

gtgc

ttaca

taaa

tgca

gtat

tttta

acct

gcct

ggca

cgct

ttagg

ttggc

gtta

426

3415

835

ZN

F740

NO

aagt

aggg

cacg

ctct

caga

gacc

agga

taga

gagt

cagg

gaac

ctgg

gaaa

gagt

agtg

ccag

ttccg

ggta

ggct

gctg

cacc

aggc

ccta

ccag

ctc

aggc

tata

aaca

gtct

gcttt

gccc

caag

tcttt

tccg

tcca

cccc

caac

agcc

ttgtc

atca

ctta

gcta

ctga

tcac

gccc

atgg

cttg

acat

tgga

gggt

taca

ttagt

ggag

tccg

ccac

agct

tcga

accc

tctc

ccca

gatg

ccct

ttgcc

tctg

ctgt

ggcc

ctgg

ggttt

tatc

aact

g

427

3764797

—NO

tggg

actg

tcaa

tcat

tggc

tctg

cctc

tctg

acca

caga

ctaa

atat

atga

ccag

tcta

acct

gtta

agca

taac

aata

tgga

cact

ggga

gaga

agcc

tctt

gaaa

tcct

ttgct

gaac

ggat

catg

taca

agct

gcca

agag

ttcat

ctc

428

2431813

—NO

tgat

gcac

agttt

agga

gcag

gaaa

gcca

tgtc

ttgga

tcca

gga

429

2468734

—NO

tgcc

caag

tcct

tgaa

tcct

acag

acct

tgct

aatg

gctc

cgttc

acga

cacc

caac

tggt

cctg

aact

ctta

ggat

taac

ccgt

ttgct

tatg

gctg

agga

a430

2512616

—NO

ccta

acta

ggag

agtg

ttttc

aagg

gaga

gattg

ctat

agca

tcag

cctc

ttggg

tttgg

agaa

tgag

ctta

acca

tgag

attta

ggttt

gagc

atgt

ttact

ata

agta

aaaa

gcat

tttcc

tgga

gtct

ggca

aata

ttgtg

gaag

atgt

ac

431

3242

348

—N

Oaa

gaga

atgg

gcaa

aggg

agcg

ggta

ggat

ggcg

gccg

cacc

acca

gcca

cgga

ctgg

gaga

ggcc

cttc

tgtg

tttcc

agat

gaga

agag

agct

caag

gaat

ccca

ggaa

taga

ctcc

atgg

aaaa

gaat

gaaa

aaaa

tcag

agaa

aagc

caaa

tatc

caaa

agag

432

3316

358

CD

151

YE

Stg

ggtg

agttc

aacg

agaa

gaag

acaa

catg

tggc

accg

tttgc

ctca

agta

cctg

ctgt

ttacc

taca

attg

ctgc

ttc43

334

7382

8T

A0K

3N

Otc

ccac

tagc

gatc

agct

gaca

ttcct

aact

gaag

gctg

caat

gtgt

tgct

tattc

atttt

gtac

cgtg

ggag

ctgc

gggg

acta

gcag

agag

ctaa

acta

434

2453

074

Clo

rfll

YE

Scc

cgga

agct

gcca

ccta

atat

tgttc

tgaa

gagc

agcc

gaag

cagt

ttcca

cD

435

3144

603

C8o

rf83

NO

cagg

aatg

caag

cact

gcta

ccta

acta

aaga

ccttg

gcttt

ggaa

acat

ctta

cccc

ttggc

agct

ctcc

agag

tttag

acttg

gcag

catc

aaag

ac43

630

3593

7G

NA

12N

Oag

cact

cctc

ccac

gggc

ctgg

gaag

gcaa

atgt

gtttt

ctga

actg

tgttg

agac

cgtg

tgtg

tgtg

tgtg

tgtg

tgtg

tgtg

tgtg

tgtg

tgtg

ttggg

gtgt

cttg

tgaa

gtcc

tgct

aacc

tcttg

tcag

caga

atat

tcga

gaaa

tgc

437

3854

106

C19

orf4

NO

cttc

aaag

tgga

gtag

tggc

acag

agac

cata

tggc

ctgc

agaa

tgga

aaat

gtca

cctg

tttgg

cctc

ttacc

agaa

aaat

ttgcc

aacc

gctc

aact

agg

2gt

gtga

tgga

gaat

ccca

aggt

gtcc

cttc

cctc

ccaa

agcc

actc

aggg

aatc

atct

gtac

c

438

2604

179

USP

40Y

ES

ttgca

atgg

ggag

tgac

gttc

aacc

tggg

acag

aaat

ggaa

atcg

tagt

agaa

gaaa

caat

atct

gt43

926

2569

6PD

E12

NO

tagt

ggga

ctttt

aagc

atct

ctga

aata

aaaa

acttc

ttttta

caga

caag

catta

tagt

ttgag

ttaca

gaca

acag

tgtg

tata

tatg

taat

atat

atat

agta

aaat

gaaa

tttaa

atat

gaag

ccaa

acttt

ttaaa

atta

gaaa

ctac

aaat

ggtta

tact

gatta

gtgt

ctag

ccta

gagt

ggta

acca

tgct

ttact

aattc

agtta

tgaa

atac

atta

tttat

aatg

catta

gctg

tatta

gctg

ttgct

tttttg

atgt

tcag

gata

acta

tgtta

tctc

atttc

tgca

tttaa

ttaat

agct

cgag

tatta

aaag

ccc

actc

ccttc

aaga

aaag

ctttg

atttt

cccc

agtc

atga

aagc

ccttg

tttca

aattc

tttaa

tctc

tgaa

ccta

gtat

cata

agaa

tttcc

tcttt

tgat

aaca

tctg

tact

ttcat

attc

tgct

cact

atca

aatg

tattg

ttaac

actta

gtaa

gtttg

aaaa

tgaa

gggg

tttta

tctg

cattt

gaca

ttgaa

ccttg

aagt

acttt

aagt

actc

caag

ggga

aaat

taaa

gtgg

aagt

ttcttc

ggat

cttg

ttta

440

2410

545

POM

GY

ES

catg

tgga

tgcg

gatg

cctg

aaca

acgc

cggg

gccg

agag

tgca

tcat

ccct

gacg

tttcc

cgat

ccta

ccac

tttgg

catc

gtcg

gcct

caac

atga

atg

NT

l

441

2545

098

HA

DH

NO

atgt

gtgt

gcag

aattc

tagg

cagc

acct

tagg

gagg

gact

ggga

tgag

agaa

agtg

ggac

ctgg

tggg

ctca

acca

caca

cacc

tgtc

tgtg

caga

tgc

Attt

gccc

aggc

ttctc

acca

cggt

gtac

cggg

atat

ta

442

2749

561

ET

FDH

YE

Sat

gctg

gtgc

cgct

agcc

aagc

tgtc

c44

328

4912

5D

NA

H5

YE

Sttc

ttcgg

acct

tggg

agca

gcaa

aaag

agcc

aatc

caat

ggat

acgg

agtc

cacg

attg

tcat

gcgt

gtac

tacg

ggac

atga

atct

ttcta

444

3022

356

—N

Oga

acac

ctgc

ccaa

tgtc

agct

atac

ttcag

ctct

cattt

gcac

tattc

aaac

ttata

aagt

tgaa

gagc

aacc

tacg

cctg

ttg44

524

7402

6__

_N

Ogt

ggta

gcag

ttttc

caga

tgtg

gatg

cttc

atga

tctg

gtg

446

3160

004

___

NO

tgct

ttgttg

aggg

tgta

aggg

gaa

447

3795

785

NO

aatg

ggaa

tgaa

atac

atgc

ctttt

tgttt

ttagg

ggtg

ctca

gtta

taaa

tatg

aaag

gctg

agaa

aatg

ctaa

ttgta

cagt

aaga

tcaa

ctgg

acttg

tttta

ataa

gaca

ataa

tttga

aatta

gtaa

acta

tttta

taca

aata

gtgc

taaa

acttt

ggaa

ggtc

ctca

acct

cctg

g

448

2990

169

NO

cttg

ggta

tcac

acaa

gcat

tact

gaca

ttgag

ttcat

ggaa

aata

caga

aaat

atat

acaa

aatta

atgc

caca

gaac

atga

caaa

tggc

tgtg

aggg

gag

gact

tttga

tcaa

ttgct

tgat

ctta

aact

tact

ttaga

agag

gtgg

ccag

tgcc

tgcc

aattg

gctg

ccat

gtgg

atac

ttctta

tgct

tgat

ctta

agtg

ctttt

gtgt

gtga

cagc

tcta

caca

attc

ccta

gtta

agag

ttact

tctc

acca

acca

aagg

449

3858

632

NO

gctg

actg

caga

ttcaa

ccttc

tgag

ctca

cgaa

450

2481

311

KL

RA

QY

ES

gctg

agttg

cagg

ggaa

gtac

caga

agct

g1 1

451

3726

479

RSA

Dl

YE

Stg

gccc

tggg

gcta

cgca

ccga

tgtg

ggga

tcac

tcac

cag

452

3847

164

NO

ccat

gcga

agta

ccaa

gccc

tagt

tgttc

tcca

tcca

ggag

gccg

tgtg

gctc

atcc

ctta

ccca

caga

ccct

cact

cacc

acct

tcgt

ccct

acca

tcca

cagc

accc

gctg

gccc

tgaa

gtga

ttcct

tggt

cctg

gacc

tggg

gtttt

gcat

tttgt

ctct

gagg

agga

ggtc

gcat

ggag

gggg

aggg

gatg

ggga

tgtg

ggtg

tatg

gacg

ggtg

gtgg

gtag

gggc

acgt

ctga

tcca

ctgt

cacg

gcac

ctct

ggtg

agttg

taat

gcgt

tcgt

gact

ccaa

ctga

ctgg

tcttc

acct

aac

ctgc

ttattt

ctct

gcca

acac

ctgg

gatg

gggg

tttgt

aaat

ccag

cagg

gctc

a

453

2945

519

GPL

Dl

YE

Sct

tccc

atga

ccac

acac

agga

gtgg

ggaa

acct

tact

tgta

cttc

atcg

gtttt

cttc

caaa

tcag

cgac

ggga

gtaa

cattt

ttattc

ctat

cacc

aaac

cac

ctga

aaaa

tgga

ctcc

taaa

cttc

ctca

tatg

acat

caca

ttagg

ctaa

tcat

gtac

cctc

aata

tcat

cagg

gtaa

gtgt

attta

ttctg

ttatta

ttaca

tttgt

agt

gcaa

gagc

tgga

cact

ctag

aatc

ttcca

tgca

cact

acttt

ggga

gg

o45

429

6060

6—

NO

ctaa

ggct

ggat

ctcc

gtttc

tttcc

acct

gctc

caac

tgta

ccca

cagc

tgtg

tctg

actg

gctg

ccgt

catta

tgct

ccag

tgtg

taca

tctc

tcca

ctga

cact

ggtg

ctct

t

455

3275

073

—N

Oga

ggag

gttg

actc

agga

gaac

ttggg

456

3392

454

—N

Oga

tgct

gaat

tgaa

ctgg

gatc

ttcttg

tctg

tcaa

gccc

ttgaa

cagc

tttcc

cttta

agca

acaa

agat

gaca

agttt

ttgct

atttt

ggat

tagt

gaga

gtgt

acga

aatg

gtttc

ccttt

ccttc

cagg

caaa

aata

ccaa

caga

atct

ggct

tcgg

aatg

aaag

tgct

aattt

cattt

ggtg

acttt

caga

tttga

aata

cggg

cttg

aac

aggc

attg

tgca

ttagt

cagc

tgag

gcag

tgga

ggtta

ttttta

cgat

gcta

atta

ttattt

cctg

acag

tgat

ttact

ttatg

ttgtc

tact

gttta

cgcc

ccca

aac

tagc

cattg

tttta

ggaa

caga

attg

gttg

ggttg

tcat

gctc

ttttc

aaag

acaa

atct

tact

atttt

atgc

atag

aaat

acttt

cctg

taat

aaag

aaga

aagc

ttta

ttgaa

gaga

atct

tgca

tatg

aaat

gtaa

tctg

gata

aata

ttcaa

aact

aata

ggttt

atat

tttag

tcttg

atttt

taaa

gtat

atttt

tctg

acat

ccta

acca

ccttg

cttta

tgtg

catta

aagt

taaa

tctg

tttta

ctgg

gatg

cggc

tgaa

t

457

3428624

MYBPC

YE

Sca

tttga

gatg

caga

tcat

caag

gcca

aaga

taac

tttgc

agga

aatta

caga

tgcg

aggt

cacc

tata

agga

taag

tttga

cagc

tg1

458

3869530

—N

Occ

atta

cagc

agca

ggat

ccag

tgac

ccgg

gatg

ctca

catc

tctc

cctg

acgt

gggc

ggag

tagc

ccct

tcct

ccca

aggt

cact

gtcc

tgtc

caac

ccc

gtgc

tccc

ctag

cccg

ttggg

aggt

ggac

agtg

agac

atct

tccc

a

459

3180781

—N

Ota

ttggg

agtc

ctgt

caga

agct

gcct

gcta

cagg

gtct

ttagc

tttcc

ttaga

ttttc

aaag

aggt

ttgtg

atcc

aaga

agaa

taga

gtttt

gaat

ctag

atttt

atac

taaa

cgat

cact

ttaga

ttttc

agga

gtgt

gtgc

ctag

tttgt

gatta

agtta

460

3319155

PPFIBP

YE

Scc

acag

tgct

gcta

gtaa

tgaa

acct

acca

ggaa

cgct

tggc

acgt

ctag

aagg

ggat

aagg

agtc

cctc

atat

tgca

2

461

3428

631

MY

BPC

YE

Sct

tgat

cctg

cata

tcag

gttg

acaa

agga

ggca

gagt

gagg

tttgt

tgtg

gagc

tggc

agat

ccaa

agttg

gagg

tgaa

atgg

tata

aaaa

tggt

caag

aa1

attc

gacc

cagt

acca

a

462

3435

265

LR

RC

4Y

ES

agcc

gaaa

gccg

tgat

tccg

atct

acga

aggc

gatta

ccac

cctg

agcc

cctg

accg

taga

ggtg

caga

tcca

gctg

aacc

agtg

ccgc

tcgg

cgga

gg3

aggc

tctg

cgca

tgttc

gccg

t

463

3697

431

___

NO

ggaa

agcg

gggc

agac

aaag

tatc

caaa

agt

464

3928

125

NO

gggc

actc

accc

aagt

aatg

tcca

aaca

atat

ttttc

catg

tccc

ccct

cccc

caga

acac

acac

aggc

aaag

gcag

agat

gttta

ctgt

gagg

tcac

atgg

catg

aagc

aaat

gcag

cctta

tctg

tttat

tatta

caac

agcc

agtta

gcat

tggc

aaat

gtgc

tttgg

ttaca

aaca

tggt

ttctg

ctaa

taat

ttcat

gaag

aag

ctttt

agga

tatg

tgac

cattt

attc

ttagt

ataa

tcaa

tcat

tgaa

ggat

aaaa

atca

gagt

ataa

aagt

ttata

ctct

ggca

aata

taaa

taca

tgca

caga

agttt

ctga

cagt

ttaaa

tttga

gcat

atttg

aaat

atta

aagg

catg

aaat

ttaaa

aata

caca

tacg

tgaa

acta

tggt

gaac

atgt

tatg

ggttt

gtcc

catg

gttta

actc

tgct

cagc

ccac

gattc

ttagc

tggg

tcag

tcaa

tagt

ctat

tttta

tcat

tttct

accc

tgttg

taca

gcat

gatc

atat

c

465

2769

166

—N

Ogt

gggg

tcag

agaa

gata

ttagg

aaa

466

3545

551

C14

orfl

NO

tggc

gcat

atca

gcag

acgg

cggt

cact

actg

tggc

tcat

ttaaa

tctg

tgttc

agct

ccgg

gcct

ctttt

ttcag

gaat

ccttg

tttcg

ggac

accc

agtg

gac

78

a46

738

9944

3—

NO

gact

tacc

tgga

gagc

gcga

gaac

tggt

gtag

ctta

cgtg

gagt

gaga

agag

atgg

ggaa

catg

tgaa

tgag

gtca

gagc

ggttg

cagg

aaac

ggac

tgct

gctg

tagg

ccat

tttaa

agac

ttttg

atttt

cctc

tgaa

ctgc

cgag

tattt

tcag

caga

ggag

taac

atga

tctc

actta

ttttta

acgg

gctta

ctct

ggct

gc

468

3182

036

NO

aaga

ttgag

gaga

agag

tagt

gaca

a46

930

6308

4__

_N

Oga

gctg

ggta

caga

gtgc

ttcat

gctg

agcc

tccg

ggca

tgct

tcgt

gtac

actc

cgca

cact

ctcc

acac

acac

acgt

taca

tggc

agca

gtcc

470

3387

617

MA

ML

NO

gaaa

gcct

gtgt

atcg

ccgt

gact

ccgg

gcgc

gagc

cagt

gtca

gcaa

agcg

gcta

acaa

caga

cgag

aaag

agaa

agga

aaat

acaa

gcta

ctttt

ttt2

ttcca

tcta

taaa

gcgg

agca

aata

cagg

agat

agaa

ccag

attg

ctta

ttgcg

agtc

caga

ccct

caga

tcca

ctgg

ccgg

ggat

ggaa

tgta

caaa

agt

ggac

agaa

aagt

ggct

ggac

atga

ctcg

gtgc

aattt

gctg

gaag

tttgt

aagt

ttgac

catc

gtttg

taaa

ttact

ctcg

gaag

agttt

gtct

ctct

tgat

actg

tat

taga

atag

agcc

gggg

gtga

ggaa

taga

aacg

taag

cggg

aaag

aaaa

aaat

gtgt

tgaa

ggat

ctct

ctca

gtgg

ctag

cga

471

3566

496

—N

Occ

taag

tcac

gcct

ctgg

aact

ttggc

aagt

tcta

taga

agag

tcag

cagc

aggt

gtgg

gtca

aggt

ccca

attc

acttc

ctgc

agct

gtac

catc

ccttc

ctc

gttc

tgca

aattt

tctc

ta

472

3088

581

NO

tgat

ctca

tgat

ctca

aaac

aaag

gg47

331

2074

0—

NO

gagc

ttggt

ttttg

gtca

gaag

ccaa

gaaa

aaag

atcg

gaga

agaa

aaga

agga

atga

cctc

aact

tgct

ctgc

acgg

agga

cggg

gacg

gctc

agag

ata

aata

gc

474

3399

570

NC

APD

YE

Jcc

tgga

cgcc

agtg

agtta

ctct

caga

cacg

tttga

ggtc

ctca

gctc

aaag

gaga

tcaa

gcttt

tg3

475

4010

188

SPIN

3N

Otg

tatc

aaag

taat

gtgt

ccac

cggt

gtga

gcac

cagc

aact

cact

tcttc

ctca

gaca

tctc

taaa

gctg

gaaa

gattt

tgag

ggac

aata

tggt

ttcct

tcac

ccca

cacc

aatg

ttatg

aatg

agac

cagc

agac

caac

agca

aaca

ccta

ga

476

2638

236

NO

tcag

ctct

gcag

ccct

acag

ttacc

agct

aacc

ttg

477

3683253

NO

tgaa

tgaa

tatg

gtcc

ctgg

ggct

aaaa

gtaa

gaaa

ggag

aaaa

aaat

aaag

caac

cccc

aaat

ttgat

gaga

accc

tata

gtcc

ctga

ctga

ttgttt

cctg

gcca

tcat

catc

atca

gcttc

aact

ttgtc

aaca

cacc

ctta

atat

gggt

gtac

cttg

tttta

cagt

ttgcc

gagc

acttt

caca

ccca

ttattg

gata

tgac

acac

aac

ccgg

tgag

agtg

ctct

c

478

2502720

MARC

NO

ttcac

ttctc

tgct

cccg

aggt

gtcc

tcgg

gctc

atat

gtgg

gaag

gcag

agga

tctc

tgag

gagt

tccc

tggg

gaca

actg

agca

gcct

ctgg

agag

ggg

Occ

atta

ataa

agct

caac

atca

479

3378495

___

NO

aaaa

ctgc

cctg

gagg

atcg

gcac

g480

2642712

___

NO

atca

ttttg

ctca

ggcc

acgg

ccac

t481

2798891

___

NO

cattt

ccca

gtgc

tgta

tact

ccta

tctc

ccag

tgct

gtttg

ctcc

cattt

ccca

482

3428610

MYBPC

YES

agag

aagg

aggc

cgga

acta

cacc

agca

aaag

483

3691119

NNOO

ggtc

tcgc

gcgc

cgtc

ttctc

gaga

g484

3821139

LOC

126

YYEESS

agac

cattg

tgat

gattc

ccga

ctcc

caga

agct

cctg

cgat

gtga

acttg

agtc

actc

aa075

485

2349300

—NO

gaga

attg

ggaa

tcaa

gaat

cagc

cctg

tttcc

atct

tagc

caca

ccaa

ctta

tatc

tttat

gattt

tcaa

agct

tttgc

catg

tgat

tctg

cccc

caca

aagg

cat

Ocg

gtat

ttcct

a

486

2638933

NO

tgcg

gatc

tcca

aagc

ctag

ggat

ttttc

cgta

aaag

agag

tggg

ccgt

tctg

gtta

ccct

tttat

taga

aggg

tattc

cacc

acag

agag

ccgg

aggt

tttcc

agat

gtgt

gtaa

gaga

gcag

gtgc

gcaa

ggca

agca

aatg

agcg

caaa

cagt

atta

tgga

aaac

atttg

agaa

gtta

gctc

catg

agga

ctgt

gggc

tcc

acaa

gagg

actc

gact

gggt

agcc

tggt

ctga

caca

ggta

cgtg

aaag

caga

gtat

tgct

tcaa

agct

ggaa

acct

tcca

tagg

agcc

tcac

actg

ttgga

agat

gtac

tgct

gctg

gtta

aggt

caac

ctgg

ggtg

caat

gctg

ctgt

cttc

atct

tcgg

tccc

gaag

taat

gctc

aata

agat

caaa

ggcc

ttttg

gtag

atct

cctg

487

2661085

—NO

ttcct

caca

aact

ggcc

ttcca

tttcc

agca

gagg

caaa

tcaa

attg

ccct

ttccg

ccct

catc

tcttt

g488

3037551

—YES

ggca

gtga

ggag

atcg

gtaa

cttg

ggag

t489

3215176

—NO

tggc

cgtc

tgta

caga

accc

acct

gcaa

ccac

caca

ccct

gagc

ccat

gtgg

ccgt

ctca

cctc

taag

tcac

ccaa

490

3410744

DNMlL

YES

gcat

taca

agga

gcca

gtca

aatta

ttgct

gaaa

tccg

ggag

actc

atct

ttggt

ga491

3439960

—NO

caga

gcgc

cagc

aagc

ggcc

acag

aa492

3461262

—NO

tcat

tttaa

ctct

gtgc

agag

tatc

aaat

ccat

ccat

t493

2316284

—NO

atgc

caac

gccg

acgt

ccct

gcgg

gg494

3882865

—NO

tcct

agca

gcac

acat

atgc

agct

ctt

495

3685651

—NO

aggg

gagc

ttcgt

gatc

ctgt

gcac

caag

tctc

catg

cccc

ttgttg

tacc

caga

gcac

catg

ctcc

ccgc

cagc

cccc

tgtc

cacc

cctg

ctta

gtta

taca

gcca

ttgtc

cgttt

tgtg

taga

acag

tggc

tttca

agct

tttgt

cacc

atga

tcca

tattt

taaa

ttgca

accc

tgttc

ccta

tgat

acct

496

2854

135

—N

Occ

gagg

actg

ttgaa

ttgtg

gaac

atct

ggtg

gaaa

atag

caag

aggt

gaca

gaaa

tgct

aatg

gggc

agtg

agat

gtag

acttc

aggc

agaa

ttgttg

tac

ctgt

cgag

ttgga

g

497

3314

277

—N

Ogt

ctaa

ggaa

aaca

acag

gctg

cgcg

aaat

cagc

cctc

aggg

taac

actg

aacc

tggc

gctc

ttccg

gcac

caca

cagg

aggc

gacg

cccg

ggaa

agaa

gact

gagc

ggct

cctg

tctg

aaga

cgtc

tcca

tcag

tcca

gcca

498

3724

236

NSF

YE

Stg

atgg

cgtg

gagc

agct

aaac

aaca

tcct

499

3746

906

NC

OR

lY

ES

caca

ggta

tgaa

acac

ctag

cgat

gcta

ttgag

gtga

taag

tcct

gcca

gctc

acct

gcgc

cacc

ccag

gaga

aact

gcag

acct

atca

gcca

gagg

ttgt

taag

gcaa

atca

agcg

gaaa

500

3909

730

AT

P9A

YE

Sga

ccttc

ttcag

attc

gatc

gtat

gtgt

acgc

agaa

gagc

caaa

tattg

acat

tcac

aact

tc50

134

2846

0U

TP2

0Y

ES

ttggt

tgta

cagt

tggc

acga

gatc

tgca

gatg

gattt

ctac

ccac

acttt

ccag

agttt

tttttg

acta

tcac

ctcg

atcc

tgga

gact

cagg

acac

agag

ttgtt

agaa

tggg

ctttc

acct

cgtta

tcat

atc

502

2751

975

GA

LN

TY

ES

ggga

ttattt

gcca

ttgaa

cgag

agttc

ttcttt

gaat

tggg

tctc

tatg

atcc

aggt

ctcc

agat

ttggg

gtg

750

338

9410

0C

20or

f9N

Otc

ccag

cacc

tgga

gcct

tgga

tcat

ttact

tcca

ggac

cgga

tctc

cattc

agac

cctg

atct

acag

tctc

cctg

ctcc

ctct

gccc

ttcct

ccct

ctttc

tttcc

6ct

ccct

ccct

ccct

ccct

tcttc

cccc

cttc

ccttc

cctc

ctcc

ttcct

tcct

cctc

tccc

tccc

tccc

tcct

ttcttt

cttc

ctgt

ggttt

tttcc

tctc

ttcttc

ccttc

tttct

ggttg

gtgc

tgct

gggc

cagg

tggg

aattt

ctga

ttaS

504

3908

236

—N

Oac

cttc

aggg

tgct

ttcac

aaat

gagc

tact

ggag

tattt

ttcgt

atct

ttggt

tgat

gaaa

aggc

tcat

ctcc

aaac

ttaat

ggttg

tacc

aagg

tgttt

tcat

tcct

tcaa

caag

tcac

tgag

tgct

ttcttg

gaac

acac

agcc

ttgca

ctgg

gggt

tatg

ggga

ggga

ggaa

gagg

ctgg

acag

ggtta

ctgc

atac

tgcc

ggaa

ggag

attc

tcat

ttggc

tgca

gagt

gtcg

caca

505

2407

923

—N

Oga

ggtc

tccc

gtca

ctgg

gcat

ccag

ctgg

gtgc

tacg

gccg

tggc

tcct

gcct

tctg

cagc

cctg

tcag

ggcc

caag

gcct

tcct

catc

agca

cttg

ctcc

agcc

tact

cact

ggag

ttgtg

ttctg

ggtg

ggtg

tgta

gaat

actc

gcac

tcct

acttg

gggc

atca

ggga

gctc

tcta

gcaa

tttc

506

2571

603

—N

Ottg

gaag

ctaa

cctg

ccac

attg

actta

actg

agtg

accc

cagt

tcca

aggc

aggg

cctc

taca

atttc

cagt

ttatc

tattg

tttcc

tgtg

taag

agca

gata

ctta

ctgt

aagt

ccgt

aagt

gcta

ctcg

tagg

tcaa

acaa

ccttg

atga

tatc

acac

ttcaa

ttgtc

ttata

aatc

ccat

ctga

acca

ctcc

tacc

ctat

ggta

tatg

agc

cctg

ggttt

gggt

gcta

atgc

gggg

atcc

acca

tctc

atct

cattg

ccgc

ctga

gaca

ccta

catg

gctt

507

3634

205

NO

agca

gatg

tcag

catc

cggg

tcac

ctag

508

3746

967

NC

OR

lY

ES

ccac

tgta

taac

cagc

catc

agat

acca

aggt

gtac

catg

agaa

catc

aaga

c50

936

7528

6W

DR

24N

Occ

gcct

ggtc

ttgtg

cccg

agac

gggc

ggag

gctg

gaac

ttgag

acct

caat

aaag

gaag

taga

g51

038

0965

1FE

CH

YE

Sag

ctgg

cacc

attc

atcg

ccaa

acgc

cgaa

cccc

caag

attc

aaga

gcag

tacc

gcag

gattg

gagg

cgga

tccc

ccat

caag

atat

gg51

127

9347

8A

AD

AT

YE

Sca

tattg

agca

gagg

acca

aaat

cgat

gatc

tcct

tggc

tggt

ggct

tacc

aaat

cca

512

3139

792

NO

tgtg

tcac

ttctg

cattg

ccca

gtat

tttga

gttg

gggg

aaaa

atga

actc

acct

ggcc

ccac

ctcc

tgttc

cagt

gtga

aata

ctga

cact

tgct

gcca

gccc

agc

ctcc

tcac

ataa

gcat

taga

aata

tcag

acag

tcca

ctag

gtta

gagc

acct

cattc

atga

ggttc

tgtta

tttat

tcgg

ctct

ccca

ctaa

aatg

cagg

gcat

aaat

ttatg

tgtc

tgct

ctaa

gact

gcag

ctgt

ctgc

cccc

cctc

cacc

ctcc

tcct

gccc

ttcct

gtgt

cagt

gtta

cattc

gctc

cccc

cact

tttgg

tctc

aggt

ctgt

ctcc

tttttg

ttttta

tggg

tgat

ttgca

gtga

ttcag

acag

ggca

tcct

tgca

tgttg

gcac

ttcct

ggag

gtta

ccag

gagg

cagc

catc

cttc

cttg

gctt

ggcc

aggc

atcc

ccga

ctcc

accc

cact

ttccc

cttg

gtgg

tgga

aagg

tggg

ttgga

ggtg

tgta

ctgg

ggca

cata

gccc

agga

atgt

tgct

ctga

gaa

gagg

acat

gtgc

agta

gaca

caaa

aata

taag

gaag

caat

tatg

ttcat

caag

ccga

aagt

tgca

gattt

tgag

gaaa

tgtg

tttaa

gata

ccac

taca

taat

aaa

aggg

aaaa

ccac

ttggc

attta

aata

actta

cttc

aaga

ggaa

atta

tgat

atttt

cagt

ctac

aaat

agag

tggt

tttta

agcc

aacc

ttgag

tagg

taca

agca

aatta

taaa

cagt

ctgc

tcaa

atga

tttta

ctat

actta

gact

agaa

aatg

gctc

ctct

tctc

tctc

cctc

tggt

ccct

atgt

ccca

gtgc

tgtc

cctc

atat

gtta

caa

513

3296

171

—N

Oac

atgg

ctct

ggtc

gaaa

tgtg

actg

aagc

tttgc

at51

434

7005

8PR

DM

4Y

ES

ctta

tttag

ctga

caga

ccac

ctcc

515

2830

812

NO

tggg

taac

agaa

cgca

acttt

gtct

ccaa

aaaa

taaa

taaa

taaa

ttgtta

caat

gaaa

gtgg

ctct

gtgt

tagc

cggg

agtg

g51

631

5150

4—

NO

ctta

ggga

atct

gtttc

ggtg

gctc

agag

aagg

atct

gttg

ccaa

tcag

ccga

tgcc

aggt

ctcc

ggtg

ct51

729

7882

2N

Ogg

cagg

tcca

ggaa

ctgg

gtct

ggag

ccttg

aaag

caga

ag51

834

3217

4—

NO

gtgc

gatg

gaaa

aggt

atcc

aaag

tgat

actc

ccttt

gact

ctga

gcat

cagt

tgcc

cgtg

tttca

gtca

cttc

aa51

939

2285

4PD

E9A

YE

Sga

ccaa

ctgc

ccct

gtaa

gtac

agttt

tttgg

ataa

ccac

aaga

agttg

actc

ctcg

acgc

gatg

ttccc

actta

ccc

520

3225

896

—N

Oct

ggat

ctgc

cacc

tcttc

tttcg

gctg

tgga

tggc

cctg

ggag

acac

gcct

ggcc

tcag

atgc

ccct

tgac

ccaa

ctgg

agga

aggg

tggg

gggc

ccag

caga

aaag

cctg

cagc

ctcc

ctgg

gcac

cgttt

caaa

gctg

atgc

tgct

ctcc

ctgc

tctg

ggtc

tcag

ctcc

tccc

ctct

tctg

cattg

ttgac

caac

agcc

tgg

gtct

gacg

cgga

agca

gaag

aattc

c

521

3981

141

OG

TY

ES

aatc

acgc

agtg

gtgc

acgg

caac

ctgg

cttg

tgta

tact

atga

gcaa

ggcc

tgat

agat

ctgg

caat

agac

acct

acag

gcgg

gcta

tcga

acta

ca52

230

4036

6T

WIS

Tl

NO

cctc

tgca

ttctg

atag

aagt

ctga

acag

ttgttt

gtgt

tttttt

tttttt

tttttt

tgac

gaag

aatg

ttttta

ttttta

tttttt

tcat

gcat

gcat

tctc

aaga

ggtc

gtgc

caa

tcag

ccac

tgaa

agga

aagg

catc

acta

tgga

ctttc

tcta

tttta

aaat

ggta

acaa

tcag

agga

acta

taag

aaca

ccttt

agaa

ataa

aaat

actg

gga

tcaa

actg

gcct

gcaa

aacc

atag

tcag

ttaat

tcttt

ttttc

atcc

ttcct

ctga

gggg

aaaa

acaa

aaaa

aaac

ttaaa

atac

aaaa

aaca

acat

tcta

tttat

ttat

tgag

gacc

catg

gtaa

aatg

caaa

taga

tccg

gtgt

ctaa

atgc

attc

ata

523

3847

114

PTPR

SY

ES

gagt

acca

gttc

tgtta

ccag

gcgg

cact

ggag

524

3903

914

—Y

ES

aattc

caga

gaag

ggttt

gagt

ttgga

gtttt

atct

gttg

taaa

atgg

ccct

gcttt

tag

525

2545

695

GT

F3C

2Y

ES

attc

atta

tattg

acgc

tggt

tacc

ttggt

ttcaa

ggcc

tact

tcac

tgct

cc52

624

6874

2—

NO

ggag

gttc

gttc

ataa

caca

ccct

agaa

acca

tgaa

aaac

atgg

agag

ccaa

gtgg

agtg

agtg

accc

gagt

ttaca

aagc

ctgc

aatg

atca

ttcttt

tatt

acct

gaca

ggat

ttagg

gtaa

ctag

aaaa

acaa

atac

aact

tatc

ttagg

caat

cact

tctc

tatg

atct

cagg

gagg

ctat

a

527

3332

623

TM

EM

lN

Oct

gtct

gggg

ttggc

tctc

ttaac

ccttt

ctct

gctc

ccag

cctg

cctc

acca

ggga

aggt

tgga

gggg

cctc

cctc

tggc

ttctg

catc

tgcg

ccag

caaa

c09

atca

ctgc

cgttg

gtct

ctca

tgac

ttaac

tggc

ttccc

tctg

ctgc

tgcc

ttggc

ttcct

ccta

atgc

tcgt

gctc

tcct

gtcc

ttctg

aagt

tgct

ccttg

gcca

aat

ctcc

agct

528

3457

669

—N

Ogg

cttta

tcgg

atag

ggac

agac

gagg

taag

gaag

gttg

tttaa

tgag

aggc

cttg

cttg

ccag

ccta

agct

tttaa

atttg

atgc

cagt

ggca

acaa

taaa

gtg

ta

529

3575

429

EM

L5

YE

Sgt

ggca

gaga

tggt

tgta

ttcgt

ctttg

ggat

tta53

036

7606

5...

NO

atgg

ggga

cgaa

tgcc

ggct

ggat

tcaa

g53

135

4135

3PL

EK

HN

Ogg

gccc

tgcc

caga

taaa

attg

ttggt

cttg

tctg

taat

tagt

attc

caaa

ggttc

aggt

ggtg

ttgca

tctc

cgta

tcaa

tgttc

agct

agta

ggta

aagg

gaca

Hl

tattt

ggag

ggaa

ctaa

ctct

ggcc

tagc

tact

atta

tgct

cttc

acttt

ttcttt

tttat

tctc

tcaa

gccc

cagc

atca

tgca

gtcc

tcag

ttggg

tgct

tacg

tgct

cttc

tcttc

cttg

cagc

agtc

ctca

aggc

aggg

caga

ttcct

cttta

aggt

gctc

gcat

gtta

cccc

tggg

ttctg

ctga

ccca

acat

tagc

taca

aagt

ggga

cag

tccc

acag

tgct

ccct

cttc

cttg

ttgtg

ggga

agac

cgca

aaaa

gacc

tcttt

tgct

ttagt

gact

ttgttc

ctac

tcaa

taca

ggaa

gtgt

tgac

cagc

aaa

aata

ataa

ttaca

aagg

ctaa

gttc

tgat

ttattg

ttcct

gact

cccg

tgtg

atta

actg

gaaa

ccct

g

532

2428

388

NO

tgga

gctc

tcca

aatta

agaa

tggg

tagt

gaca

aact

ttgaa

cagg

taac

aaac

aata

aattc

aaag

tata

tttag

gatta

aaca

gtca

atttc

taaa

tggg

agt

ctat

catg

tctc

ccct

ttgca

atac

tggc

ttccc

aaca

ggaa

ttcta

tact

tgtc

cagt

ccac

cata

atgg

gta

S53

328

8306

8N

Ottt

ctat

ctct

tcac

ctta

caca

cac

534

3686

201

GT

F3C

1Y

ES

aggg

ctcg

attc

cagc

ttcta

cgga

cacc

tcaa

gcgc

aact

ggat

ctgg

acca

gcta

catc

atca

acca

ggcc

aaaa

535

2933

137

—N

Oat

gagc

aagg

ctgg

tatc

tgga

gtttt

gata

aagt

536

3098

268

...N

Oag

cctc

agat

tcta

ccga

ggca

ggcg

cccc

aaat

accc

tccg

gacg

ctgg

cagc

agttg

cgtg

cttc

atct

gtcc

t53

738

0415

8—

NO

cagt

gtgc

cattg

taat

ttattg

gtgg

agtg

ctat

cattg

gtaa

caat

atca

tata

aatg

tattt

aacc

cctc

ctag

ctttt

gaag

taag

attc

atgt

taga

gcta

gaa

tttgt

ctgg

gtgc

538

3570

485

NO

tgga

gggg

cagg

atta

caca

ctga

atca

ttggc

a53

936

6605

8—

NO

ctct

tggc

ttcaa

gtga

ttgat

cctc

ccac

ctca

gcct

ccca

aaat

gctg

gaat

taca

gacg

tgag

ccac

tgtg

ccca

gcca

gctc

atct

tcga

ataa

taac

agttt

tact

tcttc

cttc

ttaat

tttta

tact

ttttc

cccc

ctttt

tcttg

cttc

attg

tattg

acta

ggat

ttctg

atac

attg

ttgat

taga

ggtg

gtga

tgga

ggac

atcc

ttgtc

tttttc

ccaa

actc

aggg

caaa

aaag

gattc

atag

ttgtg

ccat

taag

taat

ttgct

aggg

tttg

540

3692

317

NO

acaa

tgtg

gctg

tgttt

gatc

ccgc

gacg

tgtc

acttg

gaat

ctca

attta

ttgcc

aata

gacg

acgt

tgtc

aggc

acta

atttt

ctgg

tggc

gctc

catc

541

3749

798

MG

C33

NO

tcgg

gggt

caca

agcc

aaag

ccac

accg

ctag

aagg

gctc

agga

ccca

gccc

agct

cccg

tcct

cttg

gtgg

catc

aagc

ttgtg

tgat

atga

ggtc

ttat

894

gtc

542

3965

785

MA

PKl

NO

atgg

agct

gatc

cagt

aacc

tcgg

agac

ggga

ccct

gccc

agag

ctga

gttg

gggg

tgtg

gctc

tgcc

ctgg

aaag

gggg

tgac

ctct

tgcc

tcga

ggg

1gc

ccag

ggaa

gcct

gggt

gtca

agtg

cctg

cacc

aggg

gtgc

acaa

ta

543

4051

547

LO

ClO

ON

Otg

acct

tggc

ccag

aatc

cacc

aggg

cagg

gcct

gtga

acag

ggcc

aact

tggg

gccc

tcct

ccgc

cctc

tctg

gatg

cctc

ccct

tcag

cact

gggc

ct12

9722

gcca

ggca

gaca

gatg

gaca

cgtg

cttg

agga

aaca

cggg

tttta

tctg

ggcg

aggg

gttc

acgc

ctgt

gctc

cggg

gccc

ctgc

ccag

gttg

tgcc

gggt

tcag

agttg

actg

gctg

ccag

tgga

acag

agtg

tact

ttgct

aatg

aagc

ccttg

tcat

tgga

caga

tagg

ctcc

tcca

ggtc

ctcc

ctgc

cctg

taat

aaa

cgttg

ccac

cg

544

2849256

—NO

aaga

cagg

ctgg

tgct

ttcaa

aatc

agta

tttta

ttgtg

aggt

caag

caga

aatg

tact

agca

gcac

aacc

acag

atga

cact

tgttt

ggct

taaa

acaa

gaca

caca

545

3166772

—NO

tttct

tgtc

tcttg

agtg

gcgg

atca

tgcg

acac

ctcc

cgac

caca

gcat

ttggg

cgag

atat

agac

atgc

ctct

aaa

546

3886907

PIGT

YES

acaa

cgag

acat

taga

ggtg

cacc

cacc

cccg

acca

ctac

atat

cagg

acgt

catc

ctag

gcac

tcgg

aaga

ccta

tgcc

atct

atga

cttg

cttg

acac

c

g547

2474079

—NO

aggg

caca

gaga

gttc

aaca

aaca

ctga

aact

taag

tttgt

cctg

gaca

tcttc

agca

tccg

acttt

ctgg

tgga

aag

548

2661946

—NO

gcca

tcttc

ctat

cctg

gtcc

tgat

549

2963039

—NO

ttggt

ctct

atct

gggc

acag

tctc

tttgg

tact

gtgt

gtta

ggac

taga

tgttt

ttaac

atga

atga

aaac

gtgg

actc

aaaa

gaaa

cact

tttca

ggtg

tcta

taa

atct

tctta

ttttc

aagt

ttact

tagt

atttg

gtcc

tggg

gtgt

ctac

atgt

cact

cagt

tttga

ggaa

aaaa

tgag

atga

cctta

gaaa

taac

atag

aaat

taat

gtg

attg

atga

atat

cctta

gaaa

tttaa

tgag

attta

tact

tgga

atat

ggca

atta

caat

atttt

attg

aaaa

atga

atag

gtca

ccag

cctg

gcc

tgaa

tgca

tttag

acac

cgga

tcta

tttgc

atttt

acca

tggg

tcct

caat

aaat

aaat

agaa

tgttg

tttttt

gtat

tttaa

gtttt

tttttg

tttttc

ccct

caga

ggaa

gO

550

2991

676

TW

IST

lN

Oga

tgaa

aaaa

agaa

ttaac

tgac

tatg

gtttt

gcag

gcca

gtttg

atcc

cagt

atttt

tattt

ctaa

aggt

gttc

ttata

gttc

ctct

gattg

ttacc

atttt

aaaa

tag

agaa

agtc

cata

gtga

tgcc

tttcc

tttca

gtgg

ctga

ttggc

acga

cctc

ttgag

a

551

3535

849

NO

ctga

atgc

taca

acct

cgga

gaga

gaat

aggg

gagt

gttg

gtgt

ttgtg

gtga

atcg

gaaa

gcac

gtgt

ttaaa

gagg

acaa

tcac

atta

attc

agttc

cagc

tatg

agat

taca

ttgtc

aaat

catc

tgat

ttttc

aaga

gaaa

tcac

aaat

ttgaa

tttct

taaa

atga

gaaa

tcta

ctttt

taaa

taat

gacg

ggat

tttca

agta

tgtta

aaaa

tact

gtag

gcta

atac

cgaa

taag

ctaa

gcaa

aact

tttgt

ggat

caaa

ccga

aacc

atgg

gcta

ttttc

ttctc

ctcc

tcttc

ctcc

tcct

tctc

atag

gaa

taaa

acaa

ctaa

atat

aatc

ctgt

cttta

taat

ttcca

tata

ccaa

gcttt

aatta

tattt

aata

ccca

tcaa

agtta

gtta

aaat

gaac

tctg

agta

attta

tacc

ttat

ggaa

aaat

tacg

gtgt

tcta

agtc

tgac

caaa

tgtg

taga

aagt

acc

552

2488

753

CC

T7

YE

Sag

ccag

ctat

ggtg

cgga

tcaa

tgcg

ctga

cagc

agcc

tctg

aggc

tgcg

tgcc

tgat

cgtg

tctg

taga

tgaa

acca

tcaa

gaac

cccc

gctc

gact

gtg

gatg

ctcc

caca

g

553

2575232

SAP130

YES

gtga

tgtc

cagt

tcta

aagt

aacc

acag

tcct

gagg

ccga

cctc

acag

ctgc

caaa

tgct

gcta

ctgc

tcag

ccag

cagt

acag

caca

tcat

tcac

caac

554

3076375

BRAF

YES

cacg

ccaa

gtca

atca

tcca

caga

gac

555

3187656

CEPIlO

YES

aattt

gcag

caga

tatc

ccag

cagc

agaa

aggg

gaaa

taga

gtgg

caga

agca

gctc

cttg

agag

ggat

aaac

gaga

aata

gaac

gaat

gact

gctg

agtc

ccga

gcttt

acaa

tcgt

gtgt

tga

556

3286398

ZNF32

YES

actg

aagc

ccac

caca

aata

tgac

cact

ct557

3840338

ZNF808

NO

acag

atgt

cggc

cact

ttcgc

catc

ctgt

tttttg

t

558

4019

888

—N

Ogg

aaca

gagt

gtgc

caga

accc

tcag

ggtg

tttct

cagc

tcttg

tttac

gggc

cacc

ag55

938

3150

4—

NO

tggt

ttgcg

aata

tgct

caag

tctc

tgga

tgaa

ttgta

tgac

agtg

aagg

ggta

tgtg

atta

gact

gttg

tggc

tttga

ggttg

atgt

gtat

gtttt

aaag

gatta

tgat

tgag

ttgga

gatc

a

560

2540

638

—N

Oct

ccttc

tatc

ccaa

tcgg

acag

tgat

atga

ccct

gggg

atgt

tcca

tgaa

tcat

ttgttc

ctct

ttggc

ccca

tctg

attg

tgta

ctta

tctc

ctta

caca

gtcc

ttctg

acct

tgaa

atga

tcca

gaaa

agat

gtaa

aaga

gtaa

attc

tata

gtca

gttta

aaag

gcag

cagg

aaag

gattg

ggaa

gcat

tttgg

acaa

gggg

tcta

gga

gaca

ggcc

cagc

tctg

cact

tttcc

gtgg

gaca

aagg

ccttt

gcat

tctc

tcct

gta

561

3229

612

UB

AC

lY

ES

acga

ggat

gagc

gtgt

ggac

gagg

ctgc

cctg

cggc

agct

cacg

gaga

tggg

ctttc

cgga

gaac

agag

c56

238

3957

0K

LK

2Y

ES

ctca

tcca

gtct

cgga

ttgtg

ggag

gctg

ggag

tgtg

agaa

gcat

tccc

aacc

ctgg

cagg

tggc

tgtg

taca

gtca

tgga

tggg

caca

ctgt

gggg

gtgt

cctg

gtgc

accc

ccag

tggg

tgct

caca

gctg

ccca

ttgcc

taaa

gaa

563

2380

069

KC

TD

3Y

ES

ggca

gcaa

gtgt

ttacg

agcc

cata

tttgg

attg

gact

atcg

aacg

agta

gcttt

aaat

gcaa

aggt

ggttg

gagg

gcca

catg

gaga

caaa

gaca

aaat

ggt

tgct

gttg

cctc

agag

agta

gcat

catc

ttg

564

3428

646

MY

BPC

YE

Stc

tgat

tgac

aaga

cgaa

gttc

acca

tcac

aggt

ctgc

caac

156

529

9843

4R

AL

AN

Oag

taac

tgtc

cgct

agaa

gtct

gtcc

aaat

ttaaa

atgt

gtgc

cata

ttctg

gttc

ttgaa

aata

agat

tcca

gagc

tcttt

gatc

gcttt

taat

aaac

tgca

agttc

Oat

tttaa

atga

aggg

ccag

cata

tata

cttg

caag

ataa

ttttc

agct

gcaa

ggat

tcag

cacc

agtta

tgttt

gaat

gaac

cctc

ctttt

ctct

gaga

ttctg

gtcc

ctgg

aaat

ccct

ttctg

ctag

tggt

gagc

atgt

aagt

gtta

agttt

ttaat

ctgg

gagc

aggg

cata

ggaa

gaaa

atgt

cagt

agtg

ctaa

tgca

ttttg

cact

aga

acgc

ttcgg

gaaa

atat

tcat

gcttg

ccat

ctgt

tcat

ttcta

aattt

atat

tcat

aaag

ttaca

gtttg

atac

agga

atta

ttagg

agta

attc

ttttc

tgttt

ctgt

tta

taat

gaag

aaca

ctgt

agct

acat

tttca

gaag

ttaac

atca

agcc

atca

aacc

tggg

tata

gtgc

agaa

aacg

tggc

acac

actg

acca

caca

ttagg

ctgt

gtca

ccat

tgtg

tggt

gtac

ctgc

tgga

agaa

ttcta

gcat

gcta

cttg

ggga

cata

atttc

agtg

ggaa

atat

gcca

ctga

ccga

tttttt

tttttt

cctc

tttgc

agtg

gggc

tagg

acag

ttgat

tcaa

caaa

gtat

tttttt

ctttt

ttctc

agtc

ctaa

tttga

acag

gtca

aaga

tgtg

ttcag

gcat

tcca

ggta

acag

gtgt

gtat

gta

aagt

taaa

aata

ggct

tttta

ggaa

ctca

ctct

ttaga

tattt

acat

ccag

cttc

tcat

gtta

aata

tttgt

cctta

aagg

gtttg

agat

gtac

atct

ttcat

ttcgt

atttc

tcat

aggc

tatg

ccat

gtgc

ggaa

ttcaa

gtta

cc

566

3544955

—N

Ogc

tttct

cctc

ttccg

ggtc

ttgga

ctg

567

2981913

EZR

NO

cagc

taag

atgc

catg

tgca

ggtg

gattc

catg

ccgc

agac

atga

aat

568

3013230

CASDl

NO

agac

tgtc

tgca

cctg

tattc

attg

tgga

acttc

ctct

ttcat

tgga

aact

ttctta

ctca

agaa

tgac

ggca

gtat

tgttt

tctta

tatg

tgca

atga

agtg

gaat

gata

aaca

gtat

gcct

ttaat

ttata

tgtg

ttcttg

ttctg

atgt

tgttt

cctg

aaat

gattt

ttcttc

ctaa

ctgt

ggttt

tcgg

gtat

gcaa

gcct

aaat

ctttg

taca

ctttg

tctc

acag

aata

gttc

tgag

gctc

catg

acag

ggttt

tgtc

attg

ttgat

gtta

ttgttg

cttc

gtttt

ataa

aaaa

gcca

aaat

tttttt

tcca

atcc

aaac

gttc

acct

gtttc

ctttc

ctca

agct

atac

cagt

gtaa

tacc

agtta

ccct

gtgg

atcc

attta

a

569

3739

279

NO

gtgg

cagt

atct

gtga

cgat

ggga

agt

570

2409084

NO

agat

tttttg

ccac

tgcc

ttgag

gatc

cctg

attc

ctat

tgat

tttac

ctgc

ccttg

gacc

tgtc

cacc

tcta

tcttc

acct

ccac

ctcc

ctga

tccg

gtct

ctaa

tca

actc

tcac

ctgg

acaa

caga

aatg

gcag

ccca

aattg

tctc

ccac

at

571

2848243

NO

tcca

cagg

acta

gctg

gcag

atct

aacg

ttggg

gaga

gaga

caaa

ggtg

gggt

caca

ggca

gccc

cagc

gtgt

tggc

ccaa

gtta

ctgg

aagt

ttgga

gttg

ccttg

ggaa

gtgg

aagc

ttgtg

tcta

gcac

ctta

gacc

accg

ggcc

atcc

tgcc

acac

gcttg

gagt

tgct

ttgaa

ctat

gctg

ggga

aggt

gcag

gcg

gagc

tggc

tggg

aaag

tcag

catg

ggca

tgtg

aagt

ttggg

tgta

catg

acat

cagg

ctgg

cagt

ggtg

ggtg

agaa

ggag

tctg

gggt

tcgg

gcca

gagg

gtgg

gctg

gaga

tgta

ggttt

gttg

ggca

tccg

caca

gatg

gagc

ctgg

gagt

agct

gaga

ctcc

atgg

ggag

cacg

agga

tgag

ctgt

tgaa

ggca

tgag

ctct

ggac

cctg

gcat

taga

ggtc

tagg

aaat

tagg

ggca

acca

gtag

gact

tgag

aggg

gagc

ctgg

ggag

gagg

aagt

gcca

ggag

tgag

ttac

actg

gcgg

ccca

gtga

aacc

gggg

ttcct

gggg

ggcg

ggat

gtgt

gtgt

gtgg

cagg

gctg

ggtta

tctta

tacc

tttca

gaac

tatg

tttaa

agttt

tgta

gatg

taat

taga

atag

gatg

agttc

atgc

cact

ttgaa

acct

ataa

ttgta

tgaa

taat

tttga

attc

cttta

cgca

gaca

tgac

acat

cacg

gcttc

tcttt

gcgt

atga

tatc

a572

3775781

—NO

tgac

tgag

ctgt

ggac

cgca

agca

gtgg

cagc

ccct

tggc

tgct

cgct

atttt

gagt

ctgg

agag

attg

ttcac

gagg

agca

cagg

ctgt

ttggc

aaca

tca

gagc

t

573

3990538

—NO

ctgg

gtag

tcta

cgag

aaat

gtca

atta

ttatc

tcta

ctac

aact

actta

cata

tatc

taat

ggga

aaag

agtg

gggc

ttagg

tgtc

agag

tgga

tggg

agac

aaa

ggag

aagc

taca

ctaa

taaa

taca

acaa

gtgg

aagg

tacc

tgtc

ccat

tcct

aaaa

ggat

ttgtg

ggca

atgc

tggc

acttg

gtgg

ccag

gaga

atct

tctg

accc

cact

ctcc

ctcc

tcttc

agtc

ctga

agac

ccca

agaa

ccca

gtta

ggat

cccc

tggc

caga

ggtc

tctg

tgac

tgcc

tctg

gact

cagc

acgt

gca

Ogc

agct

tggg

agga

tttga

gcca

gtct

caaa

aact

tttag

cccc

agaa

tgag

acca

gtga

cccc

aagc

agga

gggc

tggg

atct

ggag

ggaa

gaga

gg00

gggt

ccaa

gggg

accc

tgtg

gctg

aggc

catg

gaga

acca

gtgc

cagg

gccc

aaga

gacc

cattt

ttcca

gtta

tcag

aggt

gact

gaca

tcttc

tgcc

act

gcct

tgag

ttcag

aaat

ttaaa

aaag

cttg

cagc

aaga

aaat

gcca

gtgt

gcaa

ctgg

gtga

ctaa

agac

ca

574

2411004

KIAA04

NO

ggac

tgac

gcgt

tccc

acttt

ctta

ctct

gcac

ctcc

ccac

tctc

ttccc

attc

aaga

acga

gtttc

tcttc

cctc

tcca

ttgga

aatc

ttgct

ccgg

aggt

ccga

a94

acac

gtat

tttaa

gcgt

gccc

ttcct

cacc

tcct

ggag

cacc

ctta

gaag

tattg

ccta

ctta

tccg

ggct

gaga

atcc

ttcat

ttttg

acct

ggct

tttttt

tcgc

ccttt

ggga

gata

aagg

tccc

tctc

cacc

ctct

acta

acac

tctg

cacc

caag

gcct

tatc

ctttg

gggt

cacc

ag

575

2642748

—NO

acag

gggc

gcat

ttgcc

tcac

aagg

aaca

tttgg

caat

gtcg

ggag

atat

tctg

ggtta

taca

agtg

ggag

atta

ggaa

tgct

actg

gcat

ctag

tggg

cag

aggc

cagg

atac

tgtg

aaac

atcc

tata

atgc

acag

gaga

gctc

ccta

caac

aaac

aatt

576

2661956

NO

atgg

acac

ccac

tttcc

atgc

ttag

577

3307945

NO

aaaa

tcca

gtcc

caac

tgca

gatc

ccta

tgca

ctcc

ccca

ac578

3789999

NO

ctct

cttc

ttgtg

gtag

gtcc

caga

aact

tcta

cttg

gggg

taca

tgag

gccc

agct

ggga

ttggg

caca

gaag

gtca

tggc

tctg

cacc

tgac

cctc

acct

tag

gggt

cagg

agag

agcc

aagg

acac

gagt

gatg

ggtta

ggga

ggac

tcag

gcac

catg

gaat

actg

tggc

catc

cttc

cata

gagg

agag

gtac

agg

tg579

3963093

EFCAB

YE

atgg

cgat

tata

ccag

actg

gctta

ggtc

gcat

cctc

acac

acga

aaat

ttaca

cattc

aaga

cccc

attc

ttcac

cgtg

taga

gtat

attc

a6

580

3589632

EIF2AK

YE

caga

gaag

ctga

cgag

gaga

gaag

t4

581

3816

037

—N

Ottt

ccat

cacc

cagc

aaac

gccg

tccc

gcag

cacc

cggg

aagc

tgcg

gagt

cggg

ctgg

ggcc

gccg

cgttg

cgca

catc

ggtc

cttg

582

3417

925

LR

PlY

ES

cggt

gaat

tcct

cttg

ccga

gcac

aaga

tgag

tttga

gtgt

gcca

atgg

cgag

tgca

tcaa

cttc

agcc

tgac

ctgc

gacg

gcgt

cccc

cact

gcaa

ggac

aagt

ccga

tgag

aagc

catc

583

3696

235

RB

M35

YE

Sac

ccgc

tgat

gact

acac

cagt

ctga

tgcc

tgttg

gtga

ccca

cctc

gcac

tgtg

ttaca

agcc

ccca

agga

B58

434

6299

8O

SBPL

YE

Saa

gaag

ctta

tcca

acgc

caac

caaa

gattt

gcat

cagc

catc

tctta

gtcc

agca

agtc

ct8

585

3962

740

TT

LL

lY

ES

ctttg

aatg

ctat

ggct

acga

catc

atca

tcga

cgac

aagc

tgaa

gccc

tg58

626

8199

7—

NO

ccca

gagc

gaga

cgac

tattc

catg

gccc

tgag

caga

caat

ttctc

tttta

aaaa

tggt

ggcc

cttta

atga

tgtta

ttatg

aggt

tttta

aatg

acat

atca

aaa

gttg

tttat

atca

caaa

aacc

caac

agtc

attta

atta

tact

aatg

aagg

tcttt

atac

gtgt

caga

tttttt

aaaa

aaga

cttc

taat

ggcc

atga

gaaa

tgga

ctg

ttgct

gctg

cttg

catc

acag

cagt

ggtg

gcag

cattc

tttgt

agag

gaag

aaca

tattt

tata

atgt

ataa

ggga

atttg

cattt

cgct

tttca

cggc

aaac

ctttc

tgtg

tttttt

gtaa

atct

aaca

attg

caac

aaca

tgga

atat

ttagt

tggg

agat

gtttg

gagt

aagt

gttg

aaag

caac

tatg

tttgc

ttgct

tttttt

ttttta

tggt

taga

gaac

aact

gtgg

cgac

tttca

caga

ttgaa

ctag

taca

gttc

aaag

gaaa

atca

tcga

cttta

gcac

atct

gata

gcta

tata

ggca

tggc

agag

gtgt

ctt

gaaa

aaac

587

2743

344

PHF1

7Y

ES

ggtc

ctag

agga

atttg

agca

gcga

tgct

acga

caat

atga

atca

tgcc

atag

agac

tgag

gaag

gcct

gggg

atcg

aata

tgat

gaag

atgt

tgtc

tgtg

aO

tgtc

tgcc

agtc

tcct

gatg

gtga

ggac

ggca

atga

588

2992873

NO

ttccc

aagc

actg

tacg

gggt

attg

ggaa

ggta

agaa

caaa

aaag

atgt

agtc

cttg

ccct

taca

ggtc

tagt

tgag

gaaa

gaaa

gggg

gattg

ttttc

cagt

tgca

ctga

atat

gaat

caga

atga

ggaa

gaaa

gtac

ttgga

agcc

tcta

gctg

actc

tggt

acca

ttcca

cggg

gcca

tgat

acct

ttctta

gtc

589

3568027

NO

acat

atttt

atgc

tatg

ccct

gggg

gtaa

aggg

tgac

taag

acgt

gtaa

ggca

cttg

cattc

taca

ggcc

attg

ctttt

catg

ggta

tagg

ttttc

tctc

ccca

gtt

agac

tgta

agcc

ttgttt

590

3830

188

FXY

D3

NO

ctgg

agac

ttcct

atgt

gtgc

attg

gggt

gggg

cttg

gggc

acca

tgag

aagg

ttggc

gtgc

cctg

gagg

ctga

caca

gagg

ctgg

cact

gagc

ctgc

ttgt

tggg

aaaa

gccc

acag

gcct

gttc

ccttg

tggc

ttggg

acat

ggca

cagg

cccg

ccct

ctgc

ctcc

tcag

ccat

ggga

acct

cata

tgca

atttg

ggat

ttac

tagt

agcc

aaaa

ggaa

tgaa

agag

agct

ctaa

ccag

atgg

aaca

ctgg

aaca

ttcca

gtgg

accc

tgga

ccat

tcca

ggaa

aact

ggga

cata

ggat

cgt

cccg

ctat

gatg

gaag

tgttc

agac

agttt

ataa

tagt

aagc

ccct

gtga

ccct

ctca

ctta

cccc

gaga

cctc

acttt

atta

caag

atct

ttcca

aata

ccca

aatg

tccc

tgca

agcc

cgtta

aata

591

4011

203

OPH

Nl

NO

tccc

aggc

tcct

atgc

aagt

tttttt

tccc

catta

tatc

acac

ttatc

tagc

aagg

gacc

ttgtg

gtttg

tggc

tttag

tggc

catc

atttc

tggg

ggttg

gcttt

tac

ccttt

ttcttg

aata

tttgc

cacc

aagt

gaaa

aatg

ttagg

acat

aaac

ccttg

ccag

gtcc

ctttc

atttg

ctat

ctct

atta

ttgga

aagg

acct

aaaa

attg

gtgt

aatg

gggc

agaa

atct

gagg

aatg

gaca

tttct

aattc

ctgt

ttgttg

aagg

gaag

ttgct

ggaa

agag

catc

agta

cttg

tttct

atgc

agat

gcct

gggc

cgta

gcttg

tctg

tagc

gtct

gtat

aatta

taat

gttg

ccca

gtgt

gagg

gaaa

gagc

tttcc

tact

tgca

ctct

tcta

ccaa

ggcc

ctgt

tagt

gcac

tgat

tata

gta

ctga

caga

taaa

ccta

gata

aaga

gata

gaga

gtga

gtac

atgc

acac

tcat

gtgc

aaac

ccac

tcag

agat

gcat

ttgga

acag

tgct

actg

aaag

gcag

tagt

cattt

tcaa

gact

gaat

tcca

aaca

tggt

ttattg

gtga

gtta

ggaa

catg

taag

gcca

agta

cact

gaga

gcct

ttttg

aaag

taat

tgag

tgga

aact

tgat

gcca

ttcta

aatc

aagg

cata

tcca

ggtg

gccc

ggttg

aact

cact

ccac

tgta

ccca

gtct

caaa

ggcc

aggt

tgct

aaga

aacc

agga

gtaa

aaga

gtca

agtg

acca

tcat

ttcac

ctgc

tgct

tgcc

ccca

atag

tagt

ctct

gtga

ggcc

ttact

gacc

tcac

ctag

gaag

tgat

ttttg

agcc

cttg

tttca

gggc

tgtg

gcct

ccct

gctc

tatc

ctga

ataa

agca

gaca

ggtg

tgca

gattt

tggc

catg

aaag

catg

gcta

atag

ggcc

acag

tccc

tttaa

agaa

acat

ggttt

gact

ctgg

ttttc

ttggg

ggaa

aata

ccac

aatc

accg

atgc

aaac

attg

gaag

atta

ttgag

agcc

ctag

aaag

ctgc

t

592

3349

796

—N

Otg

caga

aaag

gtgg

ataa

ccca

actc

tggt

ggg

593

3040

457

TW

IST

NO

tgcc

tcag

ccat

tcta

gtttt

gttg

tgtg

ttgga

ggac

agtc

taat

gaag

acag

gata

aatg

tgat

tctg

acta

gtgg

gaaa

tttca

gatta

ctttt

taat

gattg

gaN

Bat

gggc

tata

agat

attg

tgct

gaag

agaa

aaca

gttg

ttctg

ttcac

tgct

ttcat

tgag

aaaa

tgtg

gaat

gtct

cttg

acta

attg

acaa

agtg

taat

gaaa

tgac

aagc

tggt

tgaa

gctg

gtaa

tcaa

tgca

tggc

cata

tttat

tcat

tttcc

acac

acttg

acca

tcta

ctttg

tata

acac

attc

tgct

aagg

ccca

ggga

taca

atgg

caaa

caag

atag

atgt

agttc

cttc

ccttg

tggc

atgt

cata

agag

aaac

agat

gtgc

atat

acac

acaa

taaa

taag

aaaa

ttaat

aattg

tatta

agtg

gtat

gaaa

aaaa

gggg

gagg

attg

ttcac

tcac

tgtta

cctg

tgtta

gtat

ctgc

aaat

gcat

gaat

ggttg

aact

ccca

tgtc

agca

tttttg

ttgcc

attta

ttta

gtac

caga

cata

gtgc

tggt

ctca

cagc

ttaat

atttg

gtaa

tgaa

taaa

ttctg

ctag

tggt

atat

gttg

atct

gaac

ttaca

atga

tggg

atat

agaa

ttggc

agag

tggc

agat

gttc

acaa

ttgtc

taca

agta

gatg

tgct

agac

aatg

gaag

gatg

cagg

ccaa

cctc

tttga

ttaca

attg

agat

tcat

gtga

ctat

tgag

ccct

ggaa

atgt

agct

tgtc

ca

594

3895

503

—N

Ogt

ggcg

gacc

gtag

aaga

gcaa

gccc

a59

539

0765

4N

CO

A5

NO

ccag

gccc

agct

agcc

aagt

ttgga

atgg

cattt

gtca

tgtc

agta

gcca

ccac

ctttg

ttcat

tgtg

aacc

tacc

aagg

ctttc

cagc

ttcat

acac

attg

acc

agag

ctca

agct

cctg

cctg

caac

tcct

gcct

agag

ttgaa

gaaa

agca

aact

ggcc

ttggc

aggc

acag

tgtc

atca

tacc

ctca

cccc

atat

gtttg

ggg

tctg

cttg

agga

ttcat

aaat

cagc

cact

ctgg

attg

ttgag

gaat

ggcc

atgg

cagc

caca

gaaa

aaag

aattt

ttctc

tctg

agcc

aagg

ttgttt

tttgt

ttttt

tctc

ttttc

tttttt

gtttt

cattt

cattg

gaag

atct

ccaa

tgga

ctga

acag

ctcc

agtc

agca

gcag

ttacc

acaa

actg

tgaa

tctg

ggcc

ccac

cact

cttc

cct

gtta

acca

gttc

tgtc

agca

tccc

cctc

tcca

gcag

cact

tcca

tgaa

gttg

gttc

tgag

actc

tggc

cgtg

aaca

cccg

tttct

tcag

tgat

ttgttt

tggg

ctttt

ggct

caaa

accc

cagg

ctct

tgttt

ttgtc

taga

ctct

tattc

tgttt

cctg

agca

gcag

gagg

tagg

gacc

acttt

gatg

tcag

acttc

tggt

agct

ggac

atgt

tctc

gaga

tggg

tggc

tgttc

gcga

ctttt

gtac

caga

gtga

aattg

ttaga

agga

gggt

ttctg

gctg

tggt

tcta

aatg

gagc

ccca

ggaa

gctg

ccct

ctc

ccca

gggt

ttgtg

ctca

gtag

agcc

596

3679

982

—N

Oaa

gaga

cact

tttcc

ctaa

gcag

gaag

ttaat

aatta

agtta

acca

agaa

atag

aagt

gcat

gagt

attg

tttgg

aaat

atgg

agaa

ggga

agaa

gagt

aga

aaca

gctg

aaaa

gatta

aaag

tgat

tgct

ttggc

gagg

t

597

2858

366

—N

Oag

ctac

acag

gaaa

taac

acca

ccaa

aaat

aaca

cattc

aaac

tcag

aggg

caat

cttc

ccta

a59

830

4821

5M

RPS

2Y

ES

acca

tgcc

gcag

agcg

aacg

gtgg

agga

tgttt

tcct

tcgc

aagt

tcat

gtgg

ggta

ccttc

ccag

gctg

cctg

gctg

acca

gctg

gtttt

aaag

cgcc

ggg

4gt

aacc

agttg

gaga

tctg

tgcc

gtgg

tcct

gagg

cagt

tgtc

tcca

cac

599

3168

775

—N

Oat

ctgt

agcc

gtag

taaa

ttttg

gaag

ggca

aatc

aata

tggc

gggt

agag

gcta

gttg

gtga

agct

tatta

acac

agat

tcttt

tcca

ggct

aaag

ttgtc

ttca

gtgg

ttaac

ctttg

tttct

ccta

gtag

agag

gtgg

gcag

gata

ccttt

tgtc

tttgc

aaat

ctat

gtct

tgat

ttagg

caag

tgga

aggc

agag

aggt

ttcttg

cat

ctgc

tcct

tcaa

aact

acct

tcag

ta

600

3643

388

NO

ggag

gtat

tact

gagc

gcca

cctg

gctg

601

2927

513

TN

FAIP

YE

Sgt

gacg

gcaa

ttgcc

tcat

gcat

gcca

cttc

tcag

taca

tgtg

gggc

gttc

agga

caca

gact

tggt

actg

agga

aggc

gctg

ttcag

cacg

ctca

agga

a3

acag

acac

acgc

aact

ttaaa

ttccg

ctgg

caac

tgga

gtct

ctca

aatc

tc

602

3911

005

___

NO

atgc

ctga

gggc

atcg

acca

gaac

gaac

caga

cacg

agtc

cctg

ccct

ctgg

aagc

tcac

gttc

cagc

agag

gaga

gg60

339

4279

7IN

PP5J

YE

Sttc

atcc

tggg

ctac

tata

gtca

caac

caca

gcat

cctc

atcg

gcat

cact

gaac

cctt

604

2802

457

—N

Ogg

ccta

tggt

agga

ttgta

ggca

taag

tgct

ggat

cagg

agtc

atcc

ctct

tcta

cctc

tgct

gcct

tctg

atgt

ttcttt

tgcc

aacc

agca

cgcc

ggac

cagc

ccttc

ttgttt

tctc

ttttg

gttc

tagg

tcac

aact

ctttc

tc

605

2874

851

RA

PGE

YE

Sca

acac

ctga

gcgt

ctca

taat

gcat

ttaat

agaa

gaac

attc

catc

gtgg

atcc

aact

tata

taga

agat

tttct

atta

actta

cag

F6

606

3147

604

AZ

INl

YE

Sga

aattg

gcttt

acga

tgaa

catg

ttaga

cattg

gtgg

agga

ttcac

ggga

actg

aattt

ca60

738

2230

3C

CD

Cl

YE

Stg

ccat

ataa

catc

tggt

gcga

tggc

tgca

agaa

ccac

atcg

gcat

gg30

608

2767

313

—N

Oct

gtct

ttgga

ttgat

ggct

caga

gaag

atgg

cagc

atag

atct

ttaaa

gcag

tttga

gtgg

ggaa

ttcttg

gatc

ttggg

gtac

ttggc

catg

tgga

cagg

att

ggct

ggag

aagg

aggg

tcag

gtgg

cggt

cctg

ctgc

caag

gtct

gagg

gtaa

tact

gctc

ctaa

g

609

3159

245

—N

Otg

tgtg

tctc

aaac

ttcaa

gaag

tctc

tagg

ataa

ccca

aagg

caac

aagg

gaga

ccaa

aaca

agga

cgct

ggag

acat

tttag

cctc

tgat

actg

acag

ctgc

agca

aaca

gaaa

acgc

agcc

taac

cgcg

ggcc

agat

aaaa

acct

caca

610

3403

122

PTPN

6Y

ES

gaag

cagc

ggtc

agca

gaca

agga

ga61

138

4959

9__

_N

Otg

ggca

cccg

ttatc

ctag

ttact

cggg

cggc

tgag

gcag

gaca

attg

ctta

ccca

gagg

ccg

612

3534

950

KL

HD

CY

ES

tgcc

tatg

atca

ccttg

catg

gaca

gcaa

tcct

gtaa

acat

caca

gagt

ggca

tcat

ttgta

taat

tata

tgca

ttgttg

tagt

ttgca

cctg

ttggt

tttaa

tgtg

ca2

tgtg

aatg

gcct

agag

aacc

613

3631

427

...N

Occ

ctgt

tttga

tatc

ctgg

ttgtg

aaat

gtct

tatg

ttttc

tgct

aatc

tattt

gtgt

taaa

gtaa

gcag

ggttg

gttta

cagt

accg

tggc

tcaa

aagc

tagt

gtag

gca

gcttt

cctc

tcct

g

614

3779

594

NO

acgc

caag

agtc

cagt

gcaa

cgat

ccct

gcca

cacg

gtca

gccg

accc

cact

tggt

gcca

cagg

gtcc

agcc

tcgg

ccac

tctg

ggct

caac

ctttc

cag

cacg

tctg

ggag

ccca

atga

ggct

atgg

gaca

gtgt

gcat

ttccc

tcaa

ggcc

tccg

gaaa

gtca

cctg

ccac

ccac

tgtg

acct

ctga

ggct

gaaa

gga

ctaa

ggac

tcct

ttccc

catc

atttc

agct

gggc

cagt

ggct

ggct

aaaa

tcag

cgca

gcat

tccc

attc

ttctg

aaag

ccac

agct

gaaa

taat

gcac

cagc

tga

aacc

acag

tgga

caga

ctga

gatg

gcct

ccct

ctgg

gcct

ctag

ttggc

aact

ttctc

accc

gggg

gctc

ctct

ttctc

ctttt

cccg

ctcc

ttgttc

cagt

cct

taag

gcct

tctg

gaag

tgag

gtgt

cctc

atcc

aagc

tgcc

agtg

ccttc

caca

aattc

ttcat

aggt

agat

ttttc

cgca

aatg

gtct

gggg

ccca

aaa

615

3931

281

NO

cccg

agga

gcttg

tgat

gtca

ccag

tgtg

ccct

gcgg

gatc

tggg

gaac

agga

gaag

tagg

ccag

agaa

gtcg

ggttg

aaag

gtgt

gtcg

tttgc

gtcc

tgg

atct

ccct

taat

ttaac

ccca

taac

attc

cattt

taca

gata

agga

gact

gatg

ctca

ctaa

gaca

ctaa

tatg

ccca

ctca

caca

gcaa

gtcc

caag

tctc

tcc

ccaa

aatg

atttg

agaa

ttttg

aggc

acac

aaaa

ggga

gaaa

attg

agtg

cccg

tgat

ccaa

cgttc

tgca

actg

tttgg

aaac

cagg

aaag

tgga

gga

gtgg

tagt

acttc

tgaa

ccct

a

616

3110077

—NO

tggg

aaga

ggat

tcgg

actc

gtca

cact

gcag

agca

gcag

agcg

agaa

agga

tgag

aaga

ggca

gaga

aggc

gacg

gcag

aaga

aaaa

agga

aaa

actg

cggc

cgcg

atca

gagc

ctga

617

3419463

—NO

gcgc

cctc

gccc

tggg

aaac

tcac

tgga

gtgg

ggac

agat

ctca

ggcg

tttgg

cagt

cac

618

3903370

—NO

attg

tattt

ctat

tgga

cgct

gctg

ctct

aggt

tact

gagt

tt619

3609638

—NO

agaa

tcag

gaaa

attg

gtgc

aggg

attg

gcac

actg

cagg

gaga

atgc

atgg

gctc

catg

620

3227685

—NO

tcttg

ggta

ctca

ccttc

agcc

ctag

agca

ttcttt

agca

ctca

cagt

ttctc

ttctc

gtcg

ggtta

ttcttt

atat

taat

ctttt

cctg

tcca

aatta

ctct

ctat

gtct

cctg

atca

gtcc

ttgac

tgga

agca

tcaa

g

621

3349840

—NO

cata

acct

ctag

agta

gaaa

gtttc

agaa

ggaa

gaga

ttccc

caaa

ctgt

gtaa

ttccc

ttgta

aatc

tcat

tcat

tcaa

tggg

atttg

agaa

ccaa

ccac

ttgtg

cagg

tgcc

cgca

tccg

aaga

taac

ttgcc

ccca

ggag

acag

caga

taag

aaga

gggc

agag

acaa

agga

ggtc

tttttg

cgac

ttgca

tc

622

3035683

FTSJ2

NO

ccca

tgtg

tgcc

ttgac

ggga

cttc

atct

tata

gact

gtta

aact

gtca

caca

caaa

cagg

ctttc

cacc

cctg

ctct

gaga

gcac

cacg

caca

gattt

ccag

ttc

ttagt

gtgg

ctgt

ttaaa

gtag

aaaa

tctg

gggg

ctgg

gtga

ggcc

actc

atgc

ctgt

aaac

ccag

ggct

ttaga

aggc

tgag

gctg

gggg

attg

cttg

aag

tcag

gagt

tcaa

gacc

aacc

tggg

caac

atag

caac

accc

ccca

tgtc

taca

aaaa

tgaa

aaac

caaa

aagc

aaac

caaa

agaa

aaat

ctga

aattt

cca

tctg

ggga

ttaac

ttctg

tcttt

ctgg

tgaa

caat

atag

caat

tcac

gcat

tcttc

aagc

agca

aaag

ttccc

ggaa

caat

tagg

gaag

acgt

atgg

tctg

aattt

atcc

aggc

agtg

ggtc

tgct

ttggt

ttttg

ctgg

aaat

ttata

tcag

tgtc

tggg

ctcc

caag

aaca

taaa

tgta

attg

ccaa

agca

agca

gtga

tgtg

gtgt

gttta

ttttc

tttta

ctca

tcta

ggaa

cttg

acgc

agct

tta

623

3439354

ZNF84

NO

tcaa

gaaa

gagt

cccg

attg

tgttc

cagt

acct

ggttc

ttctg

gtct

624

2812078

—NO

ggca

gtgc

tgta

ggga

gcttc

atta

atta

tgat

agtc

tcgc

tgtg

tcaa

atgg

atta

caaa

tgga

acca

cctg

tggg

gagc

ctgc

aagg

ttacg

gaca

gagg

eta

625

3038635

NO

gata

tgaa

aaag

cacg

catg

caac

taac

tact

gttg

atct

gcttt

gcta

626

3088092

___

NO

acaa

gagg

gcgg

gtac

aaac

gcac

agct

tcca

gggc

tgaa

atac

a627

3337338

ALDH3

YES

atga

agga

cgag

cgtg

tgcc

caag

aacc

Bl

628

3420

557

—N

Ogt

aagt

tgcc

tgtc

gctc

ctct

gaat

ttt62

938

4126

7C

NO

T3

YE

Sat

ggcg

gaca

agcg

caaa

ctcc

aag

630

2929

962

STX

BP

YE

Stc

aagg

agcc

ttgca

cagc

atat

tcct

ggcc

ctgg

tggc

attg

aagg

cgta

aaag

gggc

agca

tctg

gagt

tgttg

gtga

atta

gcac

gagc

cagg

ctgg

c5

acta

gatg

aaag

aggg

caga

aact

tggc

gatc

tgga

agaa

agaa

ctgc

ggcc

atgt

tatc

aagt

gcag

agtc

631

2387

074

MT

RY

ES

gttg

agga

ttatg

cattg

agga

agaa

cata

tctg

tggc

tgag

gttg

agaa

atgg

cttg

gacc

catt

632

3388

958

—N

Ogt

aggt

gccg

aaca

ccgc

gagt

ctcc

gcgc

ccga

cccg

acct

cgtg

ttcga

gtgt

gtgc

acgc

tggc

gttta

tgga

gaga

ctag

aaga

gccg

ccca

cgtt

aaga

gtct

acgt

gccc

tgca

gg

633

3620

562

NO

ccca

aact

gaaa

catc

atac

ctat

ta63

438

7027

8N

Ogt

ttgac

ttctg

acta

aagg

tcttg

635

2833

045

RN

F14

YE

Sta

cctg

caag

cgga

tgag

gcta

ataa

aag

636

3030

300

CU

Ll

NO

gattg

ctgc

actg

gacg

acttt

agaa

catc

cctc

aca

637

3767

510

NO

agat

cgag

gaca

gtgt

tgag

acac

cacc

acct

c63

830

3944

4—

NO

gttc

aaac

agta

gttta

ctcc

tgcc

tcag

<>63

930

6765

3—

NO

agta

tggg

agag

gggt

aatg

ctga

gca

640

3139

926

TR

AM

lY

ES

aatta

acag

gcga

atgc

acttc

tcca

aaac

aaaa

caca

gcaa

gttta

atga

atct

ggtc

agct

tagt

gcgt

tcta

ccttt

ttgcc

641

3203

423

B4G

AL

YE

Sat

gtct

atat

ctcg

ccca

aatg

ctgt

ggtc

ggga

ggtg

tcgc

atga

tccg

ccac

tcaa

gaga

Tl

642

3875

984

___

NO

tcttt

ctct

gggt

tcat

ttcct

aact

gtct

aact

ttggg

643

2848

542

—N

Oat

ggtg

tggc

aagt

tgac

tgta

tcgt

gatg

ttagc

cgtc

ttgtg

gcag

aga

644

3134

299

NO

agac

caca

gaaa

ctgg

gcgg

gcag

caga

tgca

gaca

cagc

catc

ctat

gcat

ttag

645

3538

031

—N

Otg

acca

cgtg

cgca

aatta

tttttc

tttttt

agta

gaat

ggtg

cattt

tttgc

ctttg

tattt

gaaa

tttag

ctaa

atta

caat

agct

atca

gaac

taca

attg

acct

tagt

aattt

caaa

acca

tagt

tata

aggg

tttta

agttg

atttt

taaa

aatc

ttaag

atat

gata

ggga

tttca

aaac

tatg

tgtg

tgta

tctc

tgat

aggg

aggg

gttg

gggc

acag

acta

ataa

gtgt

gcca

aaaa

tctg

tgaa

tcca

aatg

tgta

acaa

gtgt

tgtc

tgaa

taaa

tgtc

caca

aatc

catg

ctat

tattg

646

4037

525

NO

tgta

ttaga

atgt

aatg

aact

ttaat

ggaa

tgta

ctcg

aatg

gattc

gact

ggaa

tgga

atgt

tctg

gaag

tgaa

tgga

ctcc

aatg

gaat

ggat

tcaa

aagg

aat

ggaa

tcgt

acgg

a

647

2814

589

BD

PlY

ES

agct

tctg

acat

ctct

ggag

gtttc

agca

agaa

aaga

ttgtg

tagg

ttcca

aaga

gtct

gcttt

ggca

aaaa

taga

tgcg

gaat

taga

agaa

gttg

gacc

atc

aaga

aggg

ttgga

gagg

aaac

tgta

ggag

ataa

ttcac

catc

ttc

648

2823

139

—N

Otc

ccaa

cctg

gcag

tgct

gagt

ggg

649

3113

389

CO

Ll4

YE

Sgg

acag

aacc

agct

acaa

ccat

agtg

ccta

ccac

Al

650

2853

728

C5o

rf42

YE

Sca

gcag

tgag

agtc

gtcc

agtc

catg

gctc

gtttc

atgg

ctgc

ctat

ttcac

caat

cagc

agct

ttgca

ttttg

cccc

ctca

651

3895

815

RN

F24

YE

Sgc

tcgg

atttc

ccac

atta

caac

ttcag

gatg

ccta

atat

tgga

ttcca

gaat

ctgc

ctct

caac

atat

atat

tgtg

gtttt

tggt

actg

ctat

atttg

tcttc

atcc

ttagt

ttact

cttc

tgttg

ctac

652

4013

748

BR

WD

3Y

ES

ttgttg

attta

gattc

agac

ggtc

ctgg

tact

tcat

653

3384

440

—N

Ottg

tcct

tggg

caaa

cgtg

gtat

acttt

ctca

gtgg

tggt

tgga

agga

aattt

gttg

ccct

gtca

tttcg

caag

tatg

gaaa

aaga

ccta

aagg

agaa

tttag

cagc

tgca

gccg

ctgt

tttta

ttgcg

tact

ttact

agcg

ccaa

ctct

ttaat

aatc

gcttg

ttagt

tgtta

cccc

tgttt

tatg

ggtc

aaga

gact

caat

atat

cagt

actt

tggt

aagg

ccag

gcag

c

654

4026

568

FAM

58N

Oag

gccg

ggag

tgta

ctgt

gtgc

agct

gacc

caag

gcag

ccac

atct

gcgt

ttgtc

ctttg

agag

gact

ttgac

taca

atac

aggc

atga

catc

aatg

aaag

gA

aaag

tcat

gaaa

tcga

tgag

actg

aatc

ccta

cgga

tttct

taaa

agcc

agat

ttgta

ggga

gaat

gaat

gtgc

a

655

2675

946

WD

R51

NO

gcca

ggga

tttgt

acca

tggg

acttg

gA

656

2941

689

___

NO

tctc

caac

tgca

gcga

cctg

tggc

tcttc

agat

657

2330

052

EIF

2C4

YE

Sga

aggc

agtc

atgt

gtca

ggac

agag

caac

ggcc

ggga

tcct

cagg

ccttg

gcta

aggc

tgtg

caaa

tcca

ccat

gata

ccca

gcac

acga

tgta

ttttg

658

2726

487

OC

IAD

NO

cgca

gtga

ggtc

tgac

gtca

tttcc

L

659

2902

605

LY

6G6

YE

Scc

ccag

tgac

cttg

attc

acca

acat

ccag

cctg

cgtc

gcag

D66

027

3233

2__

_N

Otc

aaaa

gattt

ggag

tcta

gagg

gcag

aaat

tgaa

gagg

ttggt

gctc

tgca

cgtc

tgag

tccg

ccca

caga

ctga

ataa

at66

123

2945

5__

_N

Ottc

ctgg

atca

caaa

gggc

tgta

gggg

ttcca

gaga

tgct

ggag

ctct

ggta

caac

agga

gggc

caca

ggc

662

2373

856

PTPR

CY

ES

gtat

ttgtg

gctta

aact

cttg

gcat

t66

324

6506

9SM

YD

3Y

ES

aaaa

agct

tggc

caga

ccac

aagc

ggga

atgc

aaat

gcct

taaa

agct

gcaa

accc

agat

atcc

tcca

gact

ccgt

tcga

cttc

ttggc

a66

430

4689

9V

PS41

YE

Stg

atgg

cagc

tgaa

atta

gcca

aaa

665

3418

387

GE

FTY

ES

ttgcc

gcttt

gcac

tgac

ctcc

agag

ggcc

agag

ggtg

ggat

ccag

cgct

atgt

cctg

cagg

ctgc

agac

cctg

ctat

cagt

cagg

cctg

gatc

aagc

atg

tggc

tcag

atct

tgga

gagc

caac

ggga

cttc

c

666

3568

670

NO

ttcttg

cagt

agtg

cgtg

agct

ctca

ctct

tgct

ctgg

ggag

tctg

gatta

gtcc

ttgag

ggaa

tgga

ttagt

tcct

gcaa

gggt

aggc

tgtta

taaa

gcca

gga

tgct

ctca

ggct

ctcc

tctg

tttgc

atgg

gttg

gcttc

c

667

2824

307

NO

aggc

acag

gctc

aatta

gtttt

tcaa

actc

tagc

caag

gcag

tattt

cattt

ggga

aatc

atgc

aaca

gaac

tgct

caat

tctta

acttc

tcct

gctg

ttaac

attta

cact

taga

ctgc

cagc

aaca

gtta

actta

aattt

tggt

ctca

aggg

aaca

aaaa

aaaa

ttgca

ttcag

aattt

aata

tagt

atttt

aaaa

ctaa

tttta

gcct

gtaa

gtc

atta

tgag

caat

agta

acttt

tgta

cctc

ctca

tcttg

tctg

ataa

tata

ttcta

tatg

ctgt

caat

ctga

ttata

tagt

ctat

atgc

taga

agttg

ctga

ttttc

attc

tgc

cacc

aaga

aaac

tgta

ctttt

attta

tggg

aaaa

ggat

ttaaa

tact

ccta

gata

ctta

aaat

tttttt

aatc

taaa

agttg

atttt

ctcc

caag

aaca

atttt

gtttg

ctttc

taca

aagt

tttaa

gttta

ataa

aatg

ccgg

taat

cacc

actg

ttttc

ctcc

ccaa

aata

aatg

ctct

gatc

cata

ttata

ttaga

gtga

tact

gtca

ctta

gtat

tgat

atct

ttaat

atttt

ttaca

tcat

gaga

cattg

ttatg

atct

tacc

tgat

tgtta

tctc

aagg

tgag

ctaa

tcat

cttta

tttgc

ctta

aaaa

atac

tgta

ctgg

ctgg

atat

ttaat

cttg

ttagt

ttagt

tata

cact

tgttt

tagt

cgag

tttaa

ttcaa

aagg

actc

ttaac

agta

tggt

gtaa

aact

caga

ttttc

tagt

ccag

acaa

attg

ctc

tcta

taac

gattt

ggca

gatc

aatg

gaga

catc

cgttt

taac

tttac

tgttc

tgta

ctta

ctat

gtag

tcat

gtgc

agct

tatc

aaca

caaa

gaat

acgg

atga

ggg

cattt

aaat

ggac

taca

agtg

actc

tgac

ttgta

aact

aggg

aagc

ctct

tgtg

tttga

cctta

aagg

ccag

agaa

aaac

tgaa

gata

gattg

actta

acta

ttgcc

aagc

agat

tatg

ggtta

cttta

tact

tcct

ttcat

tc

668

3204568

—NO

agcc

ctca

ggcc

ctac

caac

cttg

actg

tcct

gtcc

c669

3410647

—NO

ccca

ggag

tact

agttg

aggg

ccag

gctg

ctga

gaag

cagt

tgaa

gtag

ccttg

aagc

aagg

atgg

gaga

ttgct

gggt

gaga

tcaa

agat

acgc

tggg

atgg

gggt

gagt

gaaa

gtgt

gagc

aatg

agta

gagg

caag

attg

taga

tgct

gcat

ttgga

ggaa

tattt

ctga

ctgc

ataa

tcag

aggt

caga

atgg

ctag

agaa

atta

atac

agag

gtac

aagg

ctag

attta

gaag

agta

agct

aaga

acag

actg

caat

gggc

ttttg

aatg

2555029

catc

cacg

taca

cata

tgag

ctgt

acac

atag

atgt

taat

cagg

ttgct

tttttc

atttt

attta

aata

ttcaa

aata

ttgtg

tgat

tgtg

atcc

attg

agat

cattg

aag

Ul

670

—NO

tagt

atta

attta

gctg

ggaa

ttagc

agct

tatg

ttgtg

tggg

ccca

gttc

atca

atat

gtgt

gtca

aata

tcca

ccct

caga

tatc

agca

gcct

ttgac

ttgca

gtca

ga

671

3238290

MLLTl

YES

tagt

acct

taat

tggc

ctcc

cttc

a0

672

3490689

___

NO

tata

gagg

aaac

ctat

cagg

gcag

ggac

agt

673

3571835

—YES

catc

catg

gattg

ggcc

cact

actc

atag

cagc

tcct

gagg

cagg

taaa

tggg

gcaa

ggac

tcac

gcca

aata

ccac

acgc

gtat

gtca

aaca

ccca

agg

tcgg

attc

tggg

gccc

ctgc

cctc

agga

ggct

gtca

gact

gttc

cccc

taaa

caca

cttc

tgaa

ggttg

tagg

gacc

ttgcc

ctgc

tgtc

t674

2318698

PER3

YES

gggg

cacc

cgttc

atta

cttc

gaga

agca

gctc

accc

ttgca

gtta

aact

tact

tcag

gaag

agat

gccc

agac

cctc

tgaa

tctc

caga

tcag

atga

gaag

gaac

acgt

gccc

acaa

actg

agta

675

2330382

NO

tggc

ccag

ctac

atttg

caat

gatg

tgca

cgta

aaca

ctgt

taag

aggt

taaa

gcttg

tata

caat

ctgt

tact

gtga

aata

acta

aattg

ggct

ttaaa

aaaa

tct

tagt

attta

ttgat

cttc

attc

acat

atac

agttg

aaat

ttaaa

ataa

caga

tggt

tattc

caat

gctg

ctga

aacc

ttttc

taaa

aaat

acttg

ttttg

ttggt

tgaa

tgt

gatg

agag

gcgc

ttctg

ggca

gtct

ctct

tctc

tccc

accc

gtct

ttcct

cctc

cgag

tacc

ccttc

tcca

gcttt

gtac

tagc

catg

taaa

accc

aagg

ttttc

ttta

aaac

atca

gaag

agat

ctcg

tcct

ccat

gccc

caaa

aaag

ccaa

ctca

ttgga

ggtg

ttacc

c

676

3837

059

GR

LFl

NO

ttggg

tgttg

aagt

ggaa

tcgt

ttcat

ccca

gcc

677

2582

942

NO

tcaa

tcag

gtca

acca

cagg

tcat

atga

aacc

atct

tccc

aact

cccc

cacc

tcca

ctgg

ttctg

aaga

gtgg

gtgt

aaac

aatg

ggtta

aaca

atcc

agga

t

gcag

acag

ctgt

taat

cata

actg

gctc

caca

678

2876

012

NO

tgtc

tcat

ctac

caat

tcct

gcta

ttata

agat

caac

ttctg

caaa

aacc

ttatc

cacc

tcaa

gtat

cctta

gcag

c

679

3372

066

NU

P16

0Y

ES

ctttg

cctta

acttc

cacg

gata

tctg

ggcc

ctgt

ggca

tgat

gctg

agaa

ccaa

acag

tagt

gaaa

taca

tcaa

ctttg

a

680

3781

765

C18

orf8

YE

Sga

gatg

cctc

ataa

atttg

tgat

agcc

gtgc

tgat

ggaa

taca

ttcgt

tctc

ttaac

cagt

ttcag

attg

cagt

acag

681

3278

980

DC

LR

EYYE

ESS

ctgg

atca

cagg

tgca

tacc

gcca

tgcc

1C

682

3435

777

C12

orf6

NO

gttc

aagt

gcaa

tgac

acac

gcct

ataa

tccc

agca

ccttg

ggag

gcta

agac

agga

agat

cacc

tgag

ccca

ggag

ctca

agat

tgca

gtga

gcta

tga

5ac

acca

ctgc

actc

cacc

tgtc

cact

tgttc

ttgtg

tgac

agaa

caag

accc

tgtc

tcta

aaaa

ataa

gata

aaac

cata

aaga

aaca

cagt

cagt

acta

taca

agaa

taat

ggct

acttc

taga

ggga

agga

gttg

tcat

tgtg

atga

ggca

cttg

gagg

ggttc

tggg

gtgc

ctga

caaa

gttc

tgttt

cttc

acct

gggt

ggta

gtta

gaag

ggtg

tccc

cgta

tttca

aattg

tacc

tttgt

gaga

ttgta

tg

683

3524

572

EFN

B2

NO

gcta

ggct

gtct

gcga

agaa

ggct

agga

gttc

atag

aagg

gagt

gggg

c

684

3790

001

___

NO

caga

acaa

gtgc

atct

gctg

gcag

ccag

ctta

agga

gtta

gcag

ccct

caat

tcca

ataa

cgaa

cgtg

taaa

tcag

aattc

685

3301

881

TM

9SF

YE

Sga

agga

gatg

gata

aagc

agat

gttta

ttggg

gcat

tcct

tatc

ccag

ctat

ggtg

tgtg

gcac

tgcc

ttcttc

atca

atttc

atag

ccat

ttatta

ccat

gcttc

a

3ag

agcc

at

686

2745

373

LO

ClO

ON

Otg

gcag

atta

tgtg

gacc

atca

acaa

acta

ccaa

aa

1301

78

687

2774

241

...NN

OO

tgca

caga

caat

tccc

tttac

tagg

tgtc

acca

tagc

tacc

atct

tcat

ctcc

ttcaa

atgt

tgct

ttggc

attg

aggc

ttacc

ctca

cttc

ctta

tttaa

aatta

caa

ccag

ctgg

gcgt

ggtg

gttc

acat

ctgt

aatc

ccag

caat

tttgg

aggc

caag

gtgg

gcag

atcc

cttg

agct

cagg

agtta

gaga

ccag

cctg

ggca

aca

tggc

aaaa

cccc

atct

ctat

aaaa

aata

caga

aaaa

actta

gctg

ggta

atgg

tggc

acac

acct

gtag

tccc

agct

attc

ggga

ggct

gaga

cggg

agaa

tcgc

ttgag

ccca

ggag

atcc

aagc

tgcg

gtga

gtc

688

2852

754

AM

AC

YE

Sta

cgac

ttaca

ggac

agca

gatg

ggga

attc

atgg

ctgt

tgga

gcaa

taga

accc

cagt

tcta

cgag

ctgc

tgat

caa

R

689

2390

973

—N

Ottt

gcca

gtag

cctc

ataa

tgag

cgtg

aggt

agta

tctc

attg

tagt

gtta

atttg

cattt

acct

aaca

attc

gtga

tgtg

gagc

atct

tttca

tggg

cttg

ttggc

tgct

gtgt

ctct

tcttt

ggag

aagt

gtct

gttg

aagt

tgttt

gaca

tttttt

aatc

aagt

tgttg

gaca

ggttc

ccttg

ttttta

agtc

agag

tagg

tgat

gtttg

tcttg

aa

ggtta

ta

690

3457

600

AN

KR

DY

ES

acca

agag

aggc

gaac

tcca

ttgca

tgct

gctg

ccta

cgta

ggcg

atgt

ccc

52

691

2853

708

C5o

rf42

YE

Scc

ttattc

cagg

gatg

ctga

cattc

cattt

ctaa

ctag

tttttc

tgga

aagc

ttaga

gaac

atga

actta

attc

tttac

tttttg

atgt

acat

acaa

catta

aaac

gac

atca

gagc

aaaa

ctaa

aagc

caga

atgt

gttta

gagc

tggt

tcttg

ctttg

ttgttg

ctcc

tgag

tcct

atga

atca

gaaa

aatc

atcc

tcttt

aaat

gatg

aata

tgg

catg

cattt

agaa

aacc

agaa

acttt

catc

atca

gtac

tggt

taat

caag

ggat

ca

692

3055

843

—N

Occ

caga

tgga

gaca

ccca

tagc

aggg

cgcc

ggat

ccaa

tctc

ttcct

ctcc

tccc

tcgg

ccttc

ctct

cccc

acaa

accc

cagg

gtct

agaa

agta

gaag

gttc

tccc

ctct

tctc

tcct

tcct

cata

atga

actc

gatg

g

693

3139

045

AR

FGE

NO

catg

gtttg

cgga

ggtta

gattt

actg

gaaa

tgta

ttcat

actg

tgaa

ttgtg

ctct

gatg

gtta

aaag

acaa

gattg

tcaa

gcat

tccg

tatta

acag

tgga

tgta

Fl

gaaa

atttt

ttcag

atgg

acaa

aatg

tata

tggt

acag

atgt

aaag

ttttc

tatg

taaa

aaat

tctg

taca

acttt

ctgt

acaa

tattg

attc

ccat

ctgg

ca

694

3607

791

WD

R93

YE

Sct

gcct

atttg

caat

gcca

ccgg

aagt

caag

ggcc

c

695

2666

907

SLC

4A7

YE

Sac

caag

aaag

aaat

acgt

ggat

gctg

a

696

3887

309

___

NO

ccag

cagg

gggt

tccc

atcc

ttcct

697

2333

654

DPH

2Y

ES

tgga

agac

gagg

gattg

ccat

cgcc

tatg

agga

tgag

g

698

3333

566

LO

C75

1N

Ogt

ctgc

ggac

gctg

tata

ccct

cctc

cac

071

699

3278

417

FRM

D4

YYEE

SSaa

gcca

gaga

agct

cgac

accg

tcaa

gtga

aattg

gagc

cacc

cA

700

3986

088

NR

KN

Otc

gaca

cgga

gcac

ccttc

tagc

ttcttc

gtct

ccag

gact

gacg

ctca

ggct

cctc

tctc

gcct

tagc

ccaa

cttg

ctttc

ccgc

ctcg

caaa

ctcc

gg

701

2558

398

LO

ClO

ON

Otg

ccca

ccag

ccaa

ctag

acag

atgt

ggcc

tgca

ttgtc

cccc

tgga

ggca

aagg

atgt

gtgg

gtat

ttattt

attta

agat

agta

agtta

tggc

cagg

tgtg

g

1283

33tg

gctc

acgc

ctgt

aatc

ccag

cact

ttggg

aggc

cgag

gcgg

gtgg

atca

cctg

aagc

cagg

agttt

gaga

ccag

cctg

gcca

acat

ggta

aacc

ctgc

ctcc

acta

aaaa

atac

aaaa

atta

gctg

ggca

tggt

ggtg

catg

cctg

taat

ccca

gcta

ctcg

ggag

gctg

aggc

agga

gaat

cgct

tgaa

ccca

ggag

gcgg

aggt

tgca

gtga

gcca

agat

cgtg

ccac

tgca

ctcc

agcc

tggg

caac

agag

caag

actc

catc

tcta

aaat

aaat

aaat

aaat

aaat

aaat

aaat

aaa

taag

acaa

taaa

ttata

taag

cagt

gctg

aata

cagc

ttcat

cattt

aaaa

atcc

aaac

agttt

ggaa

atat

atag

acaa

gtat

ataa

atgc

tcttc

ttgca

ccc

cttc

cccc

atcc

taaa

gcct

acca

taca

ggta

ggca

ctgt

taat

tattt

ggtg

gaaa

tgttt

acac

tttttg

ctttg

cattt

acac

atgt

gagt

ggca

ggga

tagt

atct

gaga

aatta

atttt

tttct

ctcc

tgaa

ttttc

tcttt

ttctg

ccct

caca

tttat

ggag

ctca

ttacc

tcca

gagc

agct

tttca

ggtta

gaaa

actg

aattt

atct

tca

ggca

tctc

tggc

ttttg

tgtg

ctga

aagc

ttaag

cattt

aggg

caac

tcca

ggat

ttgct

gagt

ggct

catc

aaag

gatg

agga

ttctc

ttgca

caga

ctga

a

702

2830

633

—N

Ogc

attg

tgta

tgct

gaag

ccat

catc

actc

tcgc

tcac

agga

ggttc

atta

tcca

tttct

gaca

agta

gcct

tctc

cttg

atcc

tcttc

ctta

ggc

703

2546

259

___

NO

tata

ccca

catc

acta

agct

ggga

ggca

cattt

704

3615

631

TJP

lY

ES

ttccg

tgttg

tgga

tacc

ttgta

caat

ggaa

aact

gggc

tcttg

gcttg

ctat

tcga

attg

gtaa

aaat

cata

agga

ggta

gaac

gagg

catc

705

3729

022

GD

PDl

YE

Sga

gctc

ccac

ctta

ccttg

gcaa

actg

gatg

tctc

atttc

aaa

706

3729

073

YPE

L2

NO

tgat

ggcc

tcttg

tcag

gaga

gcag

tggc

acgg

gggc

gtga

ggaa

gagg

gaaa

gggg

aaac

tcta

aggg

tcct

ggcg

cggg

gaag

gggt

ggaa

ggg

tgga

ggta

ggaa

caaa

attg

cgcc

gctc

ctgg

agac

ctga

taac

ttagg

cttg

aaat

aattg

acttg

tcta

aaag

ga

707

3043777

—N

Otg

cact

acat

cgct

ggca

agaa

ttgttc

agaa

aggc

tggc

ctgc

taac

gact

tctg

ggga

gattt

tc708

3080463

—N

Oaa

ggca

ccta

caca

acat

cagg

ccac

ttgg

709

2969705

REV3L

NO

ttgct

aata

aatg

tagg

ccgg

aggg

gatg

gctta

gtgg

tcta

agca

tcag

atttg

aaat

acct

agag

tccc

tgga

actg

cagg

tttga

atgt

cagc

agag

tca

accc

agc

710

2904894

MAPKl

YE

Sat

tctg

gattt

tgga

ctgg

ctcg

gcac

acag

atga

tgaa

atga

cagg

ctac

gtgg

ccac

tagg

tggt

acag

ggct

cc4

711

3421016

—N

Oat

gcct

ccag

tatc

ggat

atgt

gggc

aggc

acaa

712

3724753

NPEPPS

YE

Stg

ggttt

tatc

ggac

ccag

taca

gctc

tgcc

atgc

tgga

aagt

ttatta

ccag

gcat

tcgt

gacc

tttct

ctgc

cccc

tgtg

gatc

gact

tgga

ttaca

gaat

g713

2600045

GLBlL

YE

Stg

ttgtg

gagc

gaaa

tatg

agag

acaa

acta

tttttg

acgg

ggaa

actg

gggt

ccaa

actg

gata

tcttg

gtgg

agaa

catg

ggga

ggct

cagc

tttgg

gtc

taac

a

714

2893581

—N

Otg

cattt

cagc

ttgga

gtgc

gcag

catg

aggc

atttg

tggt

tcag

aaaa

gagg

tcttc

ctttt

tcct

cctc

ctgt

tttct

tttcc

ttcct

tctc

ccca

actc

ccca

aag

gctta

ctgc

ctttc

ttctc

aggc

cacg

tgtg

taga

taac

ctttg

agga

aaag

atgg

tttcc

gtgc

tggg

atat

ttgga

tatta

ccta

aagg

gaca

agat

gagc

ccttt

ctttg

ccttg

ttttc

tttct

ctgg

cctc

atca

gagt

gaat

tata

tctg

actg

tgtg

acag

ttaat

tgta

ccat

ccat

cccg

tgtc

ctaa

gctg

ataa

gccc

715

3712

473

MPR

IPN

Ogt

gtgt

ccca

tcca

agttg

agca

cgcg

ccttc

ccca

gcttg

cagc

agca

cacc

ccaa

gcgc

tgct

tttca

cctg

tacc

tttgt

tttat

tatta

ttatta

ttattg

ctgt

tgttg

tcat

cgtta

actg

tggg

catg

gaa

OO

716

3026

735

—N

Occ

atga

tgtg

aaag

gtcg

ggtg

atat

ctga

gagc

tgaa

ggag

gtta

agcg

gatc

catg

ccag

gctg

acaa

gggg

aaca

ggtg

cctc

tgcc

ctgg

actg

gag

ccta

cgca

acca

tcttc

tgct

ttatc

tagc

tgct

gtct

gtct

cctg

tctc

tgcg

tgag

tgtg

tg

717

3603

221

IDH

3AY

ES

agtc

gtgc

agag

tatc

aagc

tcat

cacc

gagg

gggc

gagc

aagc

gcat

tgct

gagt

ttgcc

tttga

gtat

gccc

ggaa

caac

cacc

ggag

caac

gtca

cggc

ggtg

caca

aagc

caa

718

3820

895

CA

RM

lY

ES

ccag

gtgg

acca

gacc

ggct

ccaa

gtcc

agta

acct

cctg

gatc

tgaa

719

3183

801

RA

D23

YE

Sag

aatg

agaa

tttgg

ctgc

caat

ttB

720

3420

741

CA

ND

lY

ES

agaa

aaaa

gtgt

gaag

accc

gaca

gtgt

tgttt

taa

721

2356

132

TX

NIP

YE

Scc

tgct

atat

ggat

gtca

ttcct

gaag

atca

ccga

ttgga

gagc

ccaa

ccac

tcct

ctgc

taga

tgac

atgg

atgg

ctct

caag

acag

ccct

atct

ttatg

tatg

cccc

tgag

ttcaa

gttc

atgc

cacc

accg

actta

tact

g

722

2625

835

SLM

AP

YE

Sct

ttcaa

agag

tggc

gggg

actg

cact

tttat

tcat

caat

723

2996

070

AV

L9

YE

Sgt

ctgt

cacc

tcga

gatc

ttgtc

cttc

atttt

724

3175

548

___

NO

cctc

aatg

ggaa

ccct

ggtg

caga

a72

538

1003

4N

Ota

gctg

ttcag

gaaa

gctg

tgtg

gctg

gagc

agag

aata

tact

ggaa

atca

gaga

ggtc

aaaa

acaa

tgag

cagg

agat

atcg

gaag

aaat

gttc

ctaa

ccac

ttcac

tcttc

726

2767

097

—N

Oag

tattt

catg

acaa

ctct

aaga

aggt

tcag

cact

cagg

ggca

gaat

ccgc

aaat

atca

ccta

tttcc

aatta

tact

tcac

atgt

gcat

atgt

gcac

acac

gacg

gctg

tc

727

2853

747

—Y

ES

ttattc

tggg

gaat

gcct

gaag

ttaac

atttc

tagc

aattc

ggtg

gcat

gaga

atg

728

3016

374

—N

Ocg

cagt

ttgtc

agca

tcga

tgtg

ggac

tggg

agag

gaag

gata

ttgcc

agtta

tggt

tga

729

3845

911

LM

NB

2N

Ottt

atgg

cctg

ggaa

acaa

tttgc

atttg

tccc

caaa

tacg

ctta

gctg

tgtg

ccgc

ttaga

acga

tgcg

aaac

catc

cctc

tgtg

taag

cccg

tg73

026

4276

3—

NO

gtgg

cagg

agta

ttttc

acca

aaga

aatta

aatg

ctac

aaat

ccta

ccac

caca

ccac

tggt

ttggg

ctca

taga

aagt

ttgtta

agag

tctg

tgac

atga

ggt

ggcc

tcta

atac

agtg

agttc

aata

tttga

acttc

tgta

aaga

aaag

gatta

gattt

attc

agta

tgat

ctta

aaga

ggga

tgct

aggg

gcag

cagg

taaa

aattt

cagg

gaga

caga

ttttc

gttc

agtg

ttggg

aaac

tcct

gagg

taag

aagt

gccc

atta

ggct

gggt

ggcc

actc

acct

taga

agag

agat

acta

caga

gaa

ggct

gaaa

catg

gaag

attg

tagg

ggttg

agtg

gctc

atta

gtttg

gcca

ccaa

atc

731

3642

784

PDIA

2N

Otg

tcac

cccc

gcca

tcac

tgct

ggac

agga

gcca

cccc

cttg

ggta

ccag

aggg

agct

gtgc

attg

tgaa

taaa

ga73

231

7862

1SE

CIS

BY

ES

tgtta

ccga

ggttt

tcaa

acag

tga

P2

733

3681

988

KIA

A04

YE

Scg

atcg

gtgc

agtg

aata

gcct

ccac

agat

acaa

aattg

gcag

caaa

aaga

tcct

ggtc

tcac

ttgcc

accg

gggc

tgcc

agca

aatc

actc

tct

30

VO73

429

7375

0—

NO

ggag

cgtg

ggag

ttcat

atttt

acac

tatg

ttggt

actta

ccat

gcaa

atga

acgg

ccct

gctg

ggaa

aaga

acct

ttatc

caga

gagg

ggat

ccga

ggaa

ata

gtaa

gagt

tggg

ttccg

agaa

gctg

tgct

gcat

cacg

ggag

agct

cggt

gtta

735

3284

084

EPC

lN

Oat

ggtg

cgga

acct

gctg

tttta

tcta

tttat

tgtg

ccgt

gttta

cagt

tttttg

taca

ctgt

acct

tcat

tggt

tcct

gtgc

tgta

gtaa

atgt

gtta

ggta

gctg

tgga

ctcc

ttggt

atttt

gtaa

atgg

tata

acat

aact

tggt

tccc

ctct

gggt

ccttg

agttt

tctg

tgta

tcat

gtga

aaaa

aaat

ggtg

acat

acat

acag

aattt

taca

aaaa

aaaa

aaaa

aaaa

aaaa

ggca

tcag

tttttt

taaa

aatg

ggga

atgt

acta

ttaaa

tggg

gatc

ttcct

ggtc

tact

atca

ttagg

acaa

gtaa

caag

ctaa

aaat

gaag

tctc

ttgaa

tcttt

ccat

cccc

aact

tgcc

caca

aagc

tgtg

ggtg

gtttc

tggt

actta

aagc

acta

atat

tatg

ttgct

gctc

tgcg

aaca

gccc

agt

agtc

ccat

tt

736

3642

301

—N

Occ

acag

gaga

cacg

aggc

cgag

gtgg

cgca

gcac

ccac

ccta

caca

gcag

tggc

catg

tgcc

aatta

cacg

tgct

ggga

ggag

737

3133

236

PLA

TY

ES

tgtg

tctg

aacg

atgg

ccgc

atga

ctttg

gtgg

gcat

catc

agct

gggg

cctg

ggct

gtgg

acag

aagg

atgt

cccg

ggtg

tgta

cacc

aagg

ttacc

aac

tacc

taga

ctgg

attc

gtga

caac

atg

738

2858

415

NO

gctg

gtaa

taat

cgcg

tttttg

gtaa

aaac

acct

catg

gaat

tttttt

ccttt

ctca

taaa

atag

ctgt

ttact

gtaa

aattg

agat

agcc

tctc

aagt

ctgg

aaca

ccttt

caat

tcat

caaa

aagg

gaca

acct

aata

ttcca

aaga

agac

tcaa

tcct

tttaa

caca

cata

cattt

tagg

gcca

gtca

agag

aagt

ggcc

tgttc

tgta

ggaa

aaca

tttct

tggc

acat

tatta

tttta

agtg

attg

cagg

agac

caca

gagg

gaga

gaaa

agag

acaa

caac

aact

tcta

gcat

gcct

gggg

gatg

acttg

ctc

tttca

tattt

gtgg

aacc

ctat

gtca

agag

agaa

aaca

tcta

aaaa

taaa

aacg

cattt

actc

agat

tctc

tagg

gcaa

ggtg

caa

739

3301253

NO

cttg

tggc

attg

tgct

aaag

caaa

aagg

aatg

gaat

ttgca

atga

gaga

gcct

ttcaa

gttc

aggc

tcag

ccttt

agct

gtgt

gaac

ttgaa

ccac

tcac

aattt

ttctg

aatc

tcaa

tttcc

tcat

ctgt

aaag

tttat

ctaa

tatg

ttggt

ggtg

aggt

aatc

atat

tatta

tctc

aaat

agga

gattg

tata

tgaa

aggg

ctttg

gaaa

ggca

aatc

ccat

tattt

gttta

aatc

aattt

tttcc

ccta

aaaa

agat

agct

cata

aaag

aatg

tgaa

ctta

atct

gtat

gtgt

aattt

ctttc

aagt

ccta

tctg

atgt

tgct

tgtg

ac

740

3068212

DOCK4

YES

aatg

cctg

tagt

gtcc

agta

ccga

cgac

ccttt

ggct

gtgc

agttc

ttagc

atcg

ctga

cctg

ctaa

cagg

agag

acaa

741

3664307

—NO

ccag

caat

tctg

aggc

aggg

acca

atca

ga742

2357616

LOC388

NO

atgt

ggat

tgtc

taac

tgga

ggttg

ggag

tcca

gggt

gcag

aagg

agaa

gcttg

gagt

gcag

gattt

ggtg

gtat

gtgt

gtgg

cagt

aggc

acta

tgttc

taa

692

ttgcc

ag

743

2824047

___

NO

atga

ccag

agtc

atag

gtgg

tgat

gt744

3348756

Cllorfl

YES

attta

agcg

agag

cctc

actg

gttc

ccag

gaca

tcaa

cctg

aact

ggat

cctc

cccg

ata

745

3561991

NO

ctta

tttga

tggg

tggc

caag

atac

tggg

tagg

gtgg

tgtg

atttg

ctat

actg

agta

gatc

agta

aaca

ataa

agta

taaa

tcttg

ctttg

tagt

tgga

aggt

cagt

taac

aaat

attta

gtca

atat

gatg

ctgg

agttg

gcta

atgt

atcc

ccca

ggtc

taat

taat

gaaa

ataa

tcttg

cattg

gtct

ttagg

aaaa

tcat

tttta

ttctc

tttc

tgaa

tact

taac

cata

gttg

tttac

atgt

tttac

tgtg

gaag

taat

atct

tttat

gaat

gtttt

agag

aaaa

caat

tatg

gttc

acttg

gacc

attc

agta

atttg

tcc

agcc

tggc

tagt

ttcta

gtta

tctg

a

746

3051857

NO

agag

aaga

atcc

tccg

acgg

cttc

gtta

ccat

cctg

tctg

aagc

ggat

tgca

cgag

ccc

O747

3459696

NO

tgag

cttc

acat

gggg

tcaa

actg

gaaa

gtat

ctct

ttgct

atgc

tccc

attta

atta

aatta

ggaa

atct

gcct

aaaa

cttg

aatc

actc

ctct

tttca

gctg

gtgg

ccag

gcag

gaat

gctc

cctg

aaga

gtac

tcttt

caat

agac

ttcag

aatg

tgtta

cctg

aaaa

gtgc

tcat

gatg

aatc

aaga

catc

actg

tgttt

tcca

tact

tctg

aagt

agag

attg

tcca

ctaa

cagc

ttagg

gaaa

gcag

agta

cccg

ctca

gctg

ctct

ttttc

tggt

gtgg

tcag

acca

gctg

ggtc

ctct

gaaa

catg

aat

ccat

agtg

cttc

ctttg

ttata

ctat

ttctg

actc

agttt

tctc

taaa

cggc

tgta

aaat

ttaac

tgcc

tagc

tgta

ttttc

tttct

gtgg

acttt

atgc

tctc

atat

ttagg

agaa

agaa

taag

agaa

cacc

aact

taca

tctc

tgta

gctc

tgga

tgat

tatta

aggc

cctg

gtct

aatg

ctta

aagg

taag

catc

tgtta

tcta

tattc

aata

aaa

gagg

aaaa

tgaa

cccc

agag

agaa

atca

agtta

cttta

gaat

cgca

ggct

gtcc

catg

accc

tggt

gacc

atca

ctga

atta

748

2614179

—N

Ogt

gaag

ccat

cagt

gtct

acag

cttc

agct

attg

cccg

tgtg

caga

tggt

gctta

atct

ctct

tgtg

ccttc

caga

cctg

catt

749

3047613

—N

Oat

tagg

tgat

ggta

gcgg

acta

gccg

acgg

aggg

cagg

cagg

ggag

gggg

agag

gact

ttaca

gaaa

agga

attc

tcgg

tcga

gctc

tgcc

tgga

gat

gact

ggct

taca

ctta

ctaa

accc

agcg

ggtc

a

750

3677890

CREBB

NO

atca

acag

ccgc

catc

ttgtc

gcgg

accc

gacc

gggg

cttc

gagc

gcga

tcta

ctcg

gcc

P75

131

7792

9D

APK

lY

ES

tgac

aattc

aaga

tagt

ttgca

gcat

ccct

gg75

232

1161

3T

LE

lY

ES

tcct

ggtc

ccag

acag

tcta

agag

gcac

agat

aaac

gcag

aaat

ggac

ctga

atttt

ccaa

tgac

atca

agaa

aagg

aagg

tgga

tgat

aagg

actc

cag

ccac

ta

753

3452723

RAPGE

NO

tgtg

agaa

ggtg

aagc

ccat

aagg

caca

gaag

gagt

tcag

tgag

acca

gtga

cttc

aggc

tcag

tgtg

ggag

acca

gggg

aagg

atgg

gcat

gcag

gF3

gggc

gggg

gact

aggc

tgtg

gggg

aggc

agga

tgca

tgga

aggt

aggg

aagg

ctga

ggag

gtgg

agcc

aaag

tcgg

aggt

ggga

gaag

ggct

gtg

ggtc

cctg

tggg

accc

tcat

gggg

ctca

gggg

ctgg

aatg

aagg

aggt

agat

gaga

gggt

ctaa

agct

ggaa

catc

atga

gttg

agca

tggg

atg

754

2845333

...

NO

gggg

ctaa

catg

gacg

gtca

ggag

ctac

gt755

2852760

...

NO

tgaa

tgcc

tgaa

tctc

aaac

ttgta

cttc

atca

tgga

ctcc

agtc

ttcct

ttcac

atcc

aattt

caat

gatc

atca

atac

agtc

atttt

gctc

ctta

gccc

actc

ggac

tattt

ctct

ccat

acct

gctg

caac

tgcc

ttgac

actg

gtgt

gaca

gcct

tttaa

aaac

tggt

gtttg

gggc

tggt

atca

ctcc

agtg

gattc

756

2750640

...

NO

caat

aaga

taga

cgga

aata

taat

attta

aggt

taga

gaag

aagg

ctga

gtgt

ggtg

gctc

actc

ctgt

aatc

ccag

cact

ttggg

aggc

tgag

gcag

gaca

atca

cttg

agct

gggg

agttt

gaga

ccac

tcag

actc

acttg

agac

ca757

2807722

NO

ttctta

tgca

aaca

acac

catc

tggg

ctct

ggaa

cttc

acaa

aagg

acac

tgtta

agtc

acac

758

3338718

—NO

tcat

ccat

cagg

ctgt

gtca

gacg

cacc

tgag

ccct

c759

3482760

—NO

tgac

ccca

gacc

tagg

gttg

ctgg

tgga

760

3884900

...

NO

tgct

tcga

ttgct

ttcga

gtca

tgag

ttggt

g761

3038653

—NO

aaat

gtgg

gccc

gtta

aaga

gcaa

gact

ctag

aaag

gaat

ctag

ccaa

agag

gaca

gcgt

tggt

ggga

tggg

gata

a762

3340340

RNFl69

YES

agtc

agag

ctgt

agtg

acac

agcc

cagg

aaag

agcg

aaga

gcag

agtc

agag

cagt

tcca

ggca

acaa

agcc

aag

763

3441973

...

NO

agtg

ctgt

ctac

acgc

tgag

tatta

aatc

ctaa

atgt

gtat

cttta

gctg

acaa

cctc

tccc

ttgaa

ctct

gcac

tcac

ataa

ccaa

caat

ctaa

acct

ctcc

ctcc

cata

tgct

accc

catc

tcag

taaa

tggc

aact

tcat

tcttc

tagt

tgct

caag

tcaa

a

764

3629351

SPG21

NO

accc

ggtg

tgttc

ttgta

tagt

cagt

ggca

tcag

cacc

cgtc

agcc

ggcc

ttttc

cttc

aggt

tcgt

cagg

ctca

ccg

765

2611420

—NO

gtgc

tggc

acca

tcga

gcca

caac

tcag

gggc

ctca

tc766

3371610

—NO

acag

ttttg

agac

aggt

ggttc

aggt

g767

3795789

...

NO

gcct

ggct

cttc

ctta

ccac

ccgg

atttt

gtttt

tgct

ttctg

ggta

gagc

tctg

atgt

tgcc

aaac

agcc

tgtg

ctcc

tcgt

gaac

aatc

tctc

caga

ctca

aaat

agcg

agca

gcca

aggg

gctg

ccac

tgct

tgcg

gtcc

acag

768

3118031

NO

agga

aata

acttt

acat

gtgc

tcct

ct769

2976043

IL20RA

NO

tcct

gtgc

aaac

aagt

gagt

cacc

ccttt

gatc

ccag

ccat

aaag

tacc

tggg

atga

aaga

agttt

tttcc

agttt

gtca

gtgt

ctgt

gaga

atta

ctta

tttct

tttct

ctat

tctc

atag

cacg

tgtg

tgat

tggt

tcat

gcat

gtag

gtct

ctta

acaa

tgat

ggtg

ggcc

tctg

gagt

ccag

gggc

tggc

cggt

tgttc

tatg

caga

ga

770

3330211

NO

atta

ctga

aagt

ggcg

tgca

ctga

ca771

2397801

...

NO

atgc

caga

gact

gtga

tgttg

gaaa

772

2537317

TMEMl

YES

aata

catc

aatg

aggc

ggct

gcga

t

773

2875

953

NO

caat

agtg

caat

atca

cgac

cagg

atat

taac

attg

gtac

agtc

aaaa

tacg

gggc

atta

ccat

cacc

acaa

ggat

atct

cata

ttgcc

ctta

taaa

gcca

ccc

cact

tccc

tcct

acct

cacc

cctc

ctga

actc

ctgg

taac

caca

aatta

tcca

tttgt

ataa

gttg

gtaa

ttttg

agaa

tctta

cata

aatg

gaat

aata

cagt

atgt

aact

tttgg

gattg

acttt

ttttc

actta

gcat

aattc

tctg

aaga

ttcac

ctag

gttg

ttaca

tgtg

tcaa

tagt

ttgttc

ctttt

taaa

tttta

acttt

tattt

tttcg

agag

taa

gtct

tgca

ctcc

aggc

774

2882

417

—N

Oag

gaaa

gcat

gaga

ggtc

agca

gca

775

3095

010

—N

Oca

tgca

gtac

attg

gata

tgat

ataa

tttat

ggttt

cttg

tttgc

agct

gtttg

tatc

ttttta

atcc

caaa

ccag

acaa

aatta

taaa

cattt

tata

taca

atgt

tatc

ttgg

aaaa

agtta

gatg

taaa

taat

tcat

ctta

atct

atat

ttgag

aaat

ctga

gggg

tatta

ggaa

actc

atga

gtga

atga

acat

atag

attg

gatc

aaag

gagg

agag

tatg

agag

tagg

gaga

ccag

gtaa

aaag

gtat

cata

gtca

tc

116

3450

794

KIF

21A

YE

Sgg

atgc

tcct

ttaaa

cagc

ccag

gatc

aga

111

3627

349

—N

Otc

ttctg

gctc

ttccg

tgac

gcat

taca

acag

cca

778

2360

857

FDPS

NO

ggga

gcag

ctga

tcag

gtttc

tgac

779

3821

204

PRK

CS

NO

gtgc

ggtg

gata

ctga

ccttt

gctc

cggc

ctH

780

3665

595

FAM

65Y

ES

tgga

ggat

gagg

acgt

gcag

actc

gagt

ggct

ggA

781

2852

747

AM

AC

NO

cagg

ccca

cggc

tcaa

gtga

atttg

aata

ctgc

attta

cagt

gtag

agta

acac

ataa

cattg

tatg

catg

gaaa

catg

gagg

aaca

gtat

taca

gtgt

ccta

cR

cact

ctaa

tcaa

gaaa

agaa

ttaca

gact

ctga

ttcta

cagt

gatg

attg

aattc

taaa

aatg

gtta

tcat

tagg

gcttt

tgat

ttata

aaac

tttgg

gtac

ttata

ctaa

atta

tggt

agtta

ttctg

ccttc

cagt

ttgct

tgat

atat

ttgttg

atat

taag

attc

ttgac

ttata

ttttg

aatg

ggttc

tagt

gaaa

aagg

aatg

atat

attc

ttga

agac

atcg

atat

acat

ttattt

acac

tcttg

attc

taca

atgt

agaa

aatg

agga

aatg

ccac

aaat

tgta

tggt

gata

aaag

tcac

gtga

aaca

gagt

gattg

gttg

catc

cagg

ccttt

tgtc

ttggt

gttc

atga

tctc

cctc

taag

caca

ttcca

aact

ttagc

aaca

gtta

tcac

acttt

gtaa

tttgc

aaag

aaaa

gtttc

acct

gtat

tgaa

tcag

aatg

ccttc

aact

gaaa

aaaa

cata

tcca

aaat

aatg

agga

aatg

tgttg

gctc

acta

cgta

gagt

ccag

aggg

acag

tcag

tttta

gggt

tgcc

tgta

tcca

gtaa

ctcg

gggc

ctgt

ttc

782

3004

680

—Y

ES

tgga

tgag

tgta

aggg

acac

caag

gagg

t78

327

2223

3—

NO

tgaa

attc

ataa

aggc

atgt

gtgc

ca78

428

0596

0—

NO

ccca

gggc

atta

gagt

gacc

tcac

aaga

gtat

ctca

gaat

attta

aaaa

tttga

acac

acaa

acac

aatg

aaac

tcaa

catc

tgtc

agac

atca

cgtg

aact

act

agtg

aggt

agttc

attc

tttca

acat

aaga

ttgca

ctat

aatc

cttc

tgat

aattt

cata

tttttg

tgag

actg

ggttt

tcca

ggcc

atct

gata

aaaa

atca

agta

ctat

atgg

acac

caac

atgg

agca

gaaa

atga

gggc

agca

gtgt

ccaa

tctc

attc

cagg

tg

785

2952

396

—N

Oag

gaat

ggaa

ttaat

aggt

tgtg

gcaa

tatc

aa78

626

1292

7—

NO

caac

ccaa

tcta

cagt

tgtg

ggca

gtgg

ct

787

2640231

NO

tgcc

cggc

ctgc

aata

agta

tttct

aaat

aaga

tcac

attc

tcag

ctac

aaga

attta

ggat

ttcaa

catc

ttttg

agga

ggac

tcaa

tttaa

ccca

taag

aata

ctat

gtgg

gcca

caca

tggt

gcttc

acat

ctgt

tatc

ccag

tattt

cggg

aagt

tgaa

gcag

gagg

atca

ttgct

cagg

gcct

atgg

ggac

accg

ggtg

cata

aga

ccac

a

788

3371122

SYT

13

NO

agca

ggaa

atgg

aata

tgcg

ggtc

acac

tg789

2972930

___

NO

gctg

tgac

acaa

cagt

gtgg

cgat

gtcc

caca

gacc

tgaa

a790

3529011

___

NO

agcg

gctg

cagc

acgt

agttg

gaga

aggt

gagg

gcga

tgac

agcc

tggt

tggt

gggg

taga

tcac

cagc

acag

caat

cc791

3670860

LOClOO

NO

gagc

cagc

cacc

acgt

taga

tttta

gagt

ctcc

tgga

gcac

gtga

aaac

aact

gaaa

aagg

gtaa

ccac

acat

cattt

cact

tgtg

atgt

agct

tgcc

tgtc

tc129617

caca

ccat

gccc

ctga

agaa

tagt

atat

cacc

taca

gccc

cttc

ccca

gtca

ggaa

tgga

agtg

catg

acac

atgt

gctc

ctct

accc

cttc

catg

ctca

tgg

caga

catc

atta

atca

atta

tagc

actc

tttct

gtag

agcc

agag

acag

catc

acac

tcttt

cccc

tcct

gcat

tcca

ggcc

acca

ctac

caac

tgaa

atcg

tgt

tagt

acca

taat

gaat

gcta

tgta

ccat

tctc

tacc

ctaa

gcga

ttgca

aact

gtaa

atga

attg

ttgct

gattt

ctga

gccc

ctcc

taga

tttgg

ggta

aattc

attt

cttg

ttttc

agaa

caca

gggg

atag

ggac

accc

tgtg

cagt

tcttt

ctcc

agga

caag

gaga

ctcc

ccac

tggg

ggat

gggg

cggg

gtttc

tgcc

ttaat

ttggg

cgct

cata

gtttc

aagg

agga

gctc

tttct

ggct

ttggc

cagc

taga

agga

aagg

tgcc

ctgt

ttgtta

acttt

aaaa

tcac

tacg

ggtg

tagt

gtat

ggag

tgg

gctg

tgcc

atgc

tgga

gttc

agag

caaa

ggttc

ttcag

gtttt

cttg

cgaa

ggac

ctta

acttg

tcaa

tggc

agag

ccac

accc

ccgg

gaca

tact

tggc

agag

gaat

gcct

cttc

aggc

acat

aaac

atttt

tgca

tact

ccat

gtta

gtca

ataa

accg

tttca

taag

ggttc

tttga

ggac

atct

gact

tcaa

aggg

aaaa

aat

tcat

aattc

agac

aggc

tctc

gggg

cttc

acca

taca

acgc

ctttc

ttgta

tttgg

ttagt

tttat

gggc

ctgg

agtg

ttgac

catg

tatta

792

3844568

SHC2

NO

ttcct

ccgc

atga

gcct

ctgg

catg

gtcc

ttcct

ccag

ctgg

cccc

gggc

tggg

caga

gcct

cctc

ctgc

cggg

gccc

ctgc

ccac

cccc

tcct

ttgcc

tgg

agtg

aggg

tgttc

atac

caaa

gacg

gaac

cattt

cgcc

tttaa

agaa

aata

tatc

caga

agca

gccg

ctgc

ctcg

gagc

cctg

gccc

ttggg

tccc

cctc

tcgc

ctgg

ctgg

ttcgg

tcta

acgc

cccg

gaga

gtca

gggc

tccc

agga

ccct

gggg

agga

ggcg

gattc

cggg

cctg

gctg

ggct

tcct

cttc

ccac

ctg

agga

ctgg

gtgc

acag

ttgtc

tttga

gggg

ggac

gctta

aggt

gcttt

gggg

ttctc

aggc

cagg

atac

atgc

tggc

gctg

aagt

gcag

gcag

ccttg

agg

tcac

ctgg

gatc

tcgg

ggta

gcca

ggct

gctc

caag

acag

tgga

tatc

gagg

cagt

cgtg

aggc

ccct

actc

cacc

tggg

agca

gggg

aagg

acgt

ggt

tgcc

tggc

ctgg

gctg

cgcc

cagc

agct

tccc

ccca

gtcc

tgcc

ctcc

cagc

tgtc

gacc

caga

tggg

atgt

tc

793

2810517

GPBPl

NO

cagc

ttaca

ctgt

tttgc

ttgca

gagt

cata

tcttt

ttcgt

acaa

tgga

aatc

ctca

agtc

cact

ttgtg

cggt

ctcc

ctct

ccttc

cccc

aaaa

aaca

acaa

caac

aaaa

caaa

aacc

aaaa

agga

aaat

gtag

catg

ttggc

taaa

actg

gagc

aaag

tgca

ctaa

aaca

atttc

ctga

actc

acct

gttg

tact

attc

acct

tttaa

acc

ataa

attg

ctct

ttagc

cattt

gtag

tgca

gtaa

atgt

taca

ggaa

aaga

cttg

gcac

atttt

cttc

caaa

tttta

agag

gtga

ttttc

aaaa

gcttt

attg

gggt

atg

ttgtc

agac

cagg

gtttt

caga

gttg

atgg

aaaa

gagt

cttg

tgag

aaaa

ctta

ttttg

ataa

atta

ttaca

cacg

caga

aaaa

ctga

tcac

actg

actg

gat

ctgt

ccac

gaca

tgga

aaa

794

2377968

—NO

gtaa

gaca

cgttc

ccag

aggc

agga

c795

3020324

—NO

tatg

taat

gagc

atgt

gcat

agtg

tgtg

tatg

tgttt

gtat

gtgt

ttgtg

gggg

gtaa

tggt

ctc

796

3133424

—NO

cctg

agct

ggct

tggt

ggca

tccc

aggc

tcgt

gcca

ggac

ccag

cagg

gctg

gtttc

catg

ggcc

tgaa

aagg

ccca

catc

agaa

ttcca

gggc

atag

gcg

agga

ttact

797

3225212

RPL35

YES

cttc

ctct

ttccc

tcgg

agcg

ggcg

798

3731955

___

NO

tgga

accc

tcag

gtgt

tcgc

aggt

gt799

4012443

___

NO

ggag

tagg

ggtc

aact

ggat

tttgc

cagc

800

3145052

KIAA14

YES

ttgat

gacc

ccag

aagg

agttg

gcct

tacc

actg

cctta

cgtg

ttctc

tgta

atgt

tgca

tgcc

cacc

acct

c29

801

3542308

___

NO

ggga

cggt

gcac

atgt

gcat

tcac

atgt

gtttt

atgg

atgc

taca

gagg

aata

tcag

aaga

gagg

aaga

gggc

ccca

aaca

gccc

cttta

gctc

tgaa

a802

2385170

___

NO

atgg

cagg

cccc

aatg

tggc

gtgc

attg

ag803

2617336

CTDSP

NO

ggta

gaac

tgcc

catg

ccac

aaat

attta

tttgg

aaaa

gtag

tcat

taaa

tgaa

ccca

ctgc

ctta

aatg

tcttg

aatg

ttgca

gtca

agtg

tctg

tcat

gtgt

tga

Lta

tcca

caca

gaat

tagg

ccct

aatg

agag

cctta

gacc

ctca

acca

tgcc

ccct

tcgt

tggc

atca

cagg

gcct

tattt

ggaa

gagc

gggc

aaag

agga

tgg

aaat

cata

aaat

atttc

atgg

gaat

cgaa

ccta

ggga

tagt

gctc

cact

tctg

acga

tgga

gtga

agac

acttg

gcag

acttg

agcc

agac

acttc

acct

agt

agttc

ctga

aact

gtga

gcac

cact

gcac

taag

ccag

tgcg

gagc

tgtta

ggga

cggg

ccca

gctc

ctgc

acca

cgga

caca

gaat

gtct

ggag

agg

gcca

gcag

gccc

tctg

aggg

ttctg

gaat

ctgt

gcac

ctta

tttga

ccac

actc

caaa

attc

tgttt

ttattt

taac

ccttg

aatc

tgct

ttatg

taca

taat

caaa

atat

ctat

atct

atat

ctat

atct

atat

ctat

atat

tttta

atca

tcta

catg

taaa

tgaa

gcaa

taga

attc

taac

ataa

ggcc

aaga

aatg

agac

gaat

gtttg

gggt

ttat

gtttt

ttaag

gtaa

atac

gggt

attg

ttttta

atta

ttacc

atgt

atta

aattg

tggg

ctttg

aaac

ctaa

tgaa

acct

gtta

gcca

cttc

tctg

tgcc

atat

acttc

cca

tgtta

ccaa

aata

cccc

caac

tcttt

agcc

aaaa

gaga

accc

tgac

ctcc

tgag

tttcc

atgc

tcct

ttctg

tacc

aggt

ttaaa

tgta

gtct

tctg

gaga

agt

atttt

tgac

attg

agct

ctgg

gaca

ggac

acct

tggg

tttgt

ggac

tgca

gccc

acta

tgat

gtta

ttact

tctc

tggc

cagg

cctc

cagt

ggaa

gtgc

acag

gca

ctcc

caat

gttg

ttaat

gctc

tgtc

ttcca

tttgt

tctg

gaat

ccta

cgtg

ttggt

ctgt

ggttc

catg

cat

804

2982

034

RSP

H3

YE

Sca

tggg

gaag

acac

acat

cagt

ctcc

agaa

cccg

agga

tgag

cctg

gtgg

tcct

ggag

caat

gaca

gagt

cact

ggag

gcct

ctga

attc

ctgg

agca

gag

catg

tcac

agac

acgg

gagc

tgct

tttag

atgg

aggc

tacc

taca

aaga

acaa

ca

805

2335196

—NO

gtac

agga

atcc

agct

gtgt

ggag

cag

806

3561721

—NO

tcca

gcta

taca

cccg

taac

ccaa

cagc

ggct

caac

cctg

ggcg

ccaa

ctac

cgct

gcgt

cctc

cgcc

gcttt

tcg

807

2819696

—NO

gata

atag

tagt

atgg

atgg

cagt

ggca

t808

3408052

—NO

catg

atgg

ttgtc

ttcac

tctc

ctac

tccc

aatg

attc

ctag

aaaa

gaaa

cttta

aaac

atgt

ttcta

cttc

ccat

tctg

cagt

ttagt

aaaa

tgat

ttggt

taac

tctt

aaaa

ctttt

tgtg

gaat

aatg

ttctg

tgaa

ttcaa

gtat

acaa

ggca

ggag

gatc

acttc

aggc

cagg

agttc

cata

ccag

cttg

ggca

acat

agca

agac

cccg

tctc

taca

aaaa

acaa

aaag

agaa

aaaa

aata

tata

atac

ttgag

gtag

ttgaa

ttgcc

gtga

tttat

tgtc

acca

atat

tttta

aatc

ttata

tttat

tata

ataa

tac

acat

taca

ttttta

taac

tggg

ttata

acat

tgat

tattc

tcac

ttattc

taga

tgtg

actta

tttaa

ataa

gttta

gaat

tata

tatta

aata

caat

tata

ttaaa

aaca

tttt

tgct

tttat

gtaa

aaca

ctat

ttgcc

atga

cattt

tttgt

cacg

taat

tttgt

ttttc

tttgt

gtttg

aata

tgat

caaa

tact

tccc

aaaa

ttaaa

ctta

caaa

tgta

tat

caac

atat

tata

attc

aaaa

gctg

ttttta

tttgg

gaaa

taaa

taac

aatg

tgta

aaga

ccgg

gaat

ttgttc

tcct

acct

aagc

ctga

tgat

taaa

agac

agtg

taac

tatg

cagg

tgtta

aaca

ttttc

tata

ttctta

cagc

catc

tctg

ttcat

atat

ccat

tttta

actc

cacg

cccc

tgta

agcc

tttga

gtttg

tgat

ccct

ggtg

aaga

cagt

gacc

caca

ttgat

tttttt

tttttt

taag

gtttc

tctc

tctc

tttttt

gcttt

ttctc

tcga

atat

agga

cc

809

3628

699

HE

RC

lY

ES

attc

agcc

tcat

tggg

tatc

tgcc

ctgg

cttg

gcca

gaag

aggg

tccg

gcta

cagc

ctgg

tcag

gaga

gtct

ccag

aattg

ttgttg

gtgg

gacg

gatg

gat

ggat

ctct

ggga

ctga

ttgaa

gttg

ttgat

gtgt

ccac

catg

cacc

gtcg

agaa

ttgga

gcat

tgct

a

810

3350

729

—N

Otg

caga

cgtg

caca

ttccc

agtc

cgtg

cccc

agcc

gtcc

tggg

tccc

ctta

caag

cccg

ggtc

tgcc

acttc

accc

ttgttt

ttccc

catc

ctcc

gggt

ccac

atttc

atat

gccc

ctgc

cctc

attc

cctta

tgat

tccc

tagc

tgct

ggttc

caga

gtct

tctg

ggct

taca

gtct

cccg

gc

811

3380

411

—N

Oaa

agca

agga

aggt

attg

aaga

caca

aagt

caca

tgtg

atgg

gctc

agga

gcca

gtgt

gagg

aagg

gctg

ctca

taca

gcac

agtg

gagg

at81

223

7758

8—

NO

ccca

taga

gctc

ctaa

ccag

atgc

aaca

gtga

ctgc

gtca

ccat

tccc

cact

tttcc

caac

tacg

cagt

gaca

aacc

tacc

agct

ttacc

813

3219

836

—N

Otg

ggag

ccgt

ggat

gaaa

ttgtg

ctc

814

2737

650

BA

NK

lY

ES

catc

atga

aagc

agga

agac

atac

gggc

agag

tgca

gatg

815

2843

633

—N

Oag

gctc

gcct

tctc

aata

gcgt

gtat

ttgga

tgag

atga

gtttc

ttctg

taaa

gaga

aaaa

gatg

ttaaa

acct

cattg

tcta

aggc

ccct

catc

tgag

aagt

ctt

gtct

gacc

ctct

agcc

cagc

agga

ccaa

ggtg

tggt

gcct

ggtc

ccag

cctg

tcct

ctgc

tccc

ctgg

gctg

cagt

tggc

ccag

ttgcc

tgcc

tcca

ttaga

tac

ggag

ttgct

ctgg

ggct

gaga

tgcc

catc

tcaa

gtgc

attc

tgtc

ggaa

gggt

tctc

tgct

ggaa

ggcc

tttgg

tttta

gttg

ggat

tcca

tgag

cttta

gcc

caaa

ggtg

gcct

ccca

tact

agca

tattt

816

3478

420

—N

Occ

actg

tcca

caga

ccat

ctgg

ggcc

ctgg

aggg

agcg

ggct

gggc

cagg

gagg

aaca

actg

ggaa

gggg

cagg

gaag

aatc

actg

aaca

tcag

tgt

gaag

gtgg

cctg

a

817

2749

415

TM

EM

lN

Oag

ctttt

caag

acac

ttcct

gcat

ctct

gacc

tgttg

cacc

tctg

ttatc

ttggc

acct

ctgt

tatc

ttagc

44

818

2921

363

...N

Otg

acgc

gggt

ctta

cctg

ggct

aaat

tcaa

ggtg

ctgg

cagg

aatg

cattc

cttta

tgga

ggttt

tggg

gtag

gggg

caaa

tcca

tttcc

ttgttt

attta

gttg

ttgg

caga

attc

agttc

tttgc

agtta

aagg

atca

aagt

ctcc

tttcc

ttgttg

tctg

ttagc

tgag

ggtc

atttc

tagc

ttctg

aagg

ctgc

cttc

attc

cttg

gctc

atga

tccc

ctttt

cttc

agag

cctg

caat

agtg

ggtg

aagt

ccct

ctcc

cattt

tgaa

tcat

tcct

gtta

cttc

tatc

atcc

ctct

ctct

gacc

tacc

cttc

tgtc

ttcca

tttc

cact

gtta

aatg

tcta

tttga

ttact

ctgg

gccc

actt

819

2703

246

KPN

A4

YE

Jta

gtttt

gaac

tgtg

atgc

tcttt

caca

c82

032

2661

5W

DR

34N

Ogc

tcgc

agcc

tttct

tcgg

agag

tgg

821

3373

866

SLC

43A

YE

Jat

tact

ttaag

gatc

tgtg

tgga

ccag

atgc

tggg

ccga

ttggc

aatg

ccac

aggg

caJ

822

2852

746

AM

AC

NO

ctgg

tagc

aagt

tctg

gatc

ttata

ccca

acac

acag

caa

R82

330

2310

0N

Ogg

ctcc

tatc

ccta

cattt

caaa

tagc

atttc

tctc

acaa

ttgat

tatg

tatta

aggc

ttgtc

aacg

aaaa

ggaa

acttt

tttct

ctca

gaat

ttcta

gaac

tttttt

cttt

aaaa

agttt

tttat

tctg

tagc

caga

aaaa

tttaa

agttt

gtgc

tggg

ttgct

ttggt

tata

gaac

taat

gaag

cttg

agta

atag

tttca

gaca

ttctc

aggg

tttttc

ttctg

cagc

caga

tttta

cact

tcta

ttatc

tcag

ctgt

ctta

taaa

tgta

ttccc

tcca

tcac

acaa

tata

atta

gaat

gtat

tgat

gaac

agat

gtaa

cttc

atca

ctag

agag

acgt

taaa

taaa

ttatg

tgttg

gtat

catg

acttt

tatc

aaat

catg

aagg

atgc

catc

acttt

tatg

tgat

agtc

cattg

gtat

agta

ctaa

agttt

gtaa

gta

aaga

atgt

caga

taga

taac

aaga

taac

ttcat

tttcg

agat

ctca

taac

ctgg

gcc

824

3431

525

AT

P2A

NO

tggt

acca

tcca

gtta

agcc

cgtg

acaa

aaat

ggaa

atttc

taaa

tagc

ccaa

gtct

ccag

ggca

attg

ggaa

cagc

tttga

accc

acta

agat

gggg

tctg

2ct

atgc

caaa

acat

agat

acag

aattc

acag

tttgt

cctg

catta

ggac

attc

tcttc

aact

ttgcc

actg

taga

aagt

ggag

gtag

gtca

gcgg

atgg

tgcc

aca

ttaac

agcc

gcct

tact

gaag

tgta

gtcc

a

825

3695

469

NO

tttat

cctg

atgg

aaag

agtc

cagt

agag

agga

agag

attg

atga

tgta

ggag

agag

ga82

637

6153

5H

OX

Bl

NO

ctgc

cacc

gcca

ctaa

cgga

gatg

gccc

tggt

agag

acct

ttggg

ggtc

tgga

acct

ctgg

actc

ccca

tgct

ctaa

ctcc

caca

ctct

gcta

tcag

aaac

t3

taaa

cttg

agga

ttttc

tctg

tttttc

actc

gcaa

taaa

ttcag

a82

738

2388

4N

WD

lY

ES

actg

caga

gccg

gtat

tcca

tatc

ctgg

gaga

tgcc

tctg

atcc

ttgga

tgtg

catg

gccg

tgct

ggcc

tccc

aggc

caca

ctgc

tgac

agtg

tcca

ggga

tgg

tgtg

gtca

gtct

gtgg

agct

cagc

tacg

ggaa

aact

tcag

ggga

agca

acat

atgt

ccag

catc

aaag

aaga

aaca

ccta

cctg

tgcc

gtct

cagt

cca

gaag

c

828

2475

018

F0SL

2N

Oct

cagc

tctc

acag

gggt

aatc

atct

caag

tggt

atttg

tagc

caag

tggg

agct

atttt

ctttt

ttgtg

cata

taga

tattt

ctta

aatg

aagc

tgct

ttcttg

tcttt

tat

ttcta

aaag

cccc

ctta

tacc

ccac

tttgt

gcag

caaa

gatc

cccg

tgca

ggtc

acag

cctg

atttg

tggc

cagg

ctgg

acaa

attc

ctga

ggca

caac

ttgg

cttc

agttc

agat

ttcaa

gctg

tgttg

gtgt

tggg

acca

gcag

aagg

caaa

cgtc

cagc

caac

acac

agga

ctgt

aaga

ggac

tctg

agct

acgt

gccc

tgtg

aaga

cccc

cagg

ctttg

tcat

agga

ggtc

gttc

agct

tccc

caaa

gtca

gagg

tgat

ttgat

ttggg

gaag

actg

aata

ttcac

acct

aagt

cgtg

agc

atat

cctg

agttt

tact

tcct

tatg

gcttg

ccct

ccaa

gttc

tctc

tctc

atac

acac

acac

accc

ttgct

ccag

aatc

acca

gaca

cctc

catg

gctc

cagc

tatg

ggaa

cagc

tgca

ttggg

gctg

ccttt

ctgt

ttggc

ttagg

aact

tctg

tgct

tcttg

tggc

tcca

ctcg

cgag

gcag

ctcg

gagg

tgtg

gact

ccga

ttggg

ctgc

aggc

agct

ctgg

gacg

gcac

aggg

cggg

cgct

ctga

tcag

ctcg

tgta

aaac

acac

cgtc

ttcttg

gcct

cctg

gcca

gtct

ttctg

cgaa

tagt

cctc

tcc

ctgg

ccag

ttgaa

tggg

ggaa

gctg

ctgg

caca

ggaa

ggag

aggc

gatc

ccgg

ctga

ggct

tagg

aaat

tgct

ggag

ccgg

ctcc

aagc

agat

aatt

cact

gggg

aggt

tttca

gagt

caaa

catc

attc

tgcc

tgtg

ttggg

ggcc

aggt

gtgt

caca

caag

catc

tcaa

agtc

aaaa

gcca

tctg

gggc

tgct

gcttc

tgttt

ctca

ggct

ctgg

ggaa

agga

atct

ccct

ctcc

tctc

acttg

attc

caag

tgtg

gttg

aattg

tctg

gagc

actg

ggac

tttttt

tc

829

2987324

—NO

gttg

gtgc

ccaa

cata

tgcc

tgcc

a830

3379421

SUV420

YES

cgcc

tttcc

ttcga

ggag

ctca

aggc

attt

Hl

831

3109159

___

NO

cattc

agca

ctct

cacg

ggat

ggac

agag

cagt

gttc

atgc

ag832

2480318

___

NO

ctct

gacg

cact

tgag

gggt

tggc

tc833

2841516

C5orf41

NO

gcag

ggat

ctag

acgt

cagg

ccaa

ctga

gagc

tgac

aggg

aaga

gaga

gcta

gcta

gtat

agac

atag

acat

gaga

atca

gctc

agct

gctg

tagg

aga

aagt

cact

gaca

gaca

gtag

catc

caag

gcat

ccag

cgtta

tatg

accc

acga

aaac

cccc

aaaa

ttaaa

tata

caca

ataa

aagg

tcaa

atgt

ttttc

ttga

acaa

aagt

atat

ttata

ttgaa

aaca

atca

ggtg

aaga

gtag

accc

taat

cgcc

agta

ttt

834

3738805

FLJ3576

YES

ggag

cttc

ttacc

tgct

caca

ctgg

7

835

2771

466

NO

aaaa

gaga

gcaa

tcct

gcaa

gcca

atcc

cgac

tctg

aaaa

tcat

cact

a

836

3322962

—NO

tggt

ggtg

atgc

ttata

gtgg

agag

cctc

tacc

ttgct

gcag

ctc

837

3906050

—NO

taga

tctc

caaa

atga

cctc

tcac

ca838

3119642

—NO

ccag

agaa

agcc

gctg

acag

ggag

gaga

ggcc

ccag

cccc

tatta

caaa

ccca

gcca

tcaa

839

3125570

—NO

cccc

aaaa

ccat

ctgc

aaca

gcca

g840

3933835

—NO

ctga

tgga

ccttc

tggc

cgct

tcta

tgttt

cttc

tctg

attg

841

2802644

—NO

ggga

tcac

ttgcc

acct

ggga

tgtt

842

2854122

—NO

aagt

tctg

tgtta

gata

gtca

agta

gggt

gact

gtag

ttagc

atcc

atgt

atta

tata

tttca

aggt

agct

agaa

gact

tgaa

atgt

tccc

aaca

caga

aatg

ata

atac

tcat

gaga

taat

ggat

a

843

3147

610

AZ

INl

YE

Sgc

aaga

gttg

ggtg

tacc

tcca

gaaa

acat

tattt

acat

aagt

ccttg

caag

caag

tgtc

tcag

ataa

agta

tgca

gcaa

aagt

tgga

gtga

atat

cctg

acat

gtga

caat

gaaa

ttgaa

ttgaa

gaaa

attg

cacg

taat

cacc

c844

3398488

SNX19

YES

gggt

gaac

aaat

gccg

gctg

agct

ggg

845

3629947

NO

gacc

agct

ctga

tggg

caac

ccaa

actc

aaga

agtg

taac

ttttc

tgca

gaac

ccttc

agaa

ctta

aaag

atca

ctga

tgta

aggt

cact

agct

ggca

cctc

ttct

tata

atta

caat

taaa

tggg

caat

aact

tacc

ctta

cata

atga

caac

tact

atta

aaga

gaaa

tcat

ggca

tttga

gaac

aatg

acat

aaga

ttaaa

tcaa

ggca

ccat

ggct

aact

attc

agga

3677823

CREBB

ttttg

tgtg

cgac

aact

gcttg

aaga

aaac

tgg

846

YES

P847

3101370

NO

tagg

tgcc

ctga

aagt

tattg

ttgct

tttttt

gtttt

tttttt

ttcag

tttgt

gcgt

gtca

cttg

aatc

agaa

acca

aaca

catg

taaa

aaaa

tatc

atcc

tcaa

tgcc

cccc

atta

actc

tctc

tcca

gaag

gtga

caat

gtta

gtga

actc

aaga

ctct

cact

gatg

atgg

tattt

taca

atga

aaac

acaa

ggaa

accc

tttga

ggtc

caat

tttc

acat

cata

ttctc

caaa

tagt

aaaa

tagc

agct

ctac

atgt

tgat

gaaa

agaa

atttc

aattt

cttc

ctat

ttgttt

ttact

cata

tcaa

catta

atat

gtat

ctgg

att

tatta

atttc

caaa

aaga

aaat

tttag

ttacc

aaat

atttc

agaa

attta

ataa

agca

ttaca

tata

tgta

atta

gcac

ttatc

tacc

aaaa

aaac

atat

gtgt

atgt

att

tattt

atct

tacc

ttcac

tgaa

gttc

tttttt

ctgg

ctgg

acat

gaga

aaca

ggat

taag

tgat

caat

gctg

gcttt

atttc

ttcat

aagc

agta

atttg

ggtc

tttttc

attc

aaca

caac

gcag

cattt

tcat

aata

aattc

acaa

aaga

caat

acaa

agaa

acac

ctac

tgaa

taga

actc

tgtc

gagc

aattc

atgt

tttaa

agttg

gact

ctat

acca

aact

ggca

ttatg

gtat

tata

ggca

tttga

tttttg

ttttc

ttattt

tcag

tttgt

cagt

ttcttt

acta

ccat

tattt

ttttc

tagc

cgga

gata

acgt

ataa

tca

848

2977512

NO

gcca

agat

tagc

atat

gtga

gtgg

caca

849

2329726

NO

caag

cacc

tcgg

tata

gcat

tatta

ctga

aacc

actta

attc

ccag

ctttt

tgag

tttttt

aaaa

aaac

ccac

tgca

ctaa

gattc

acaa

ttcat

tgct

acat

acaa

atta

aagc

tagt

aaga

acac

acta

acgt

caca

agttt

ctca

ttcta

aagt

850

3626942

NO

tgca

tgct

caca

gtaa

cacg

tata

ctaa

aat

851

3823

576

RA

B8A

NO

gccc

acgg

ccac

caga

atgc

aattg

agaa

atcg

tttat

tttag

taac

tgtc

tgat

ctttt

tcaa

ctttg

gaga

tgga

ataa

gtta

aaaa

tttgc

tattt

ttcct

gtaa

cat

ctgc

tgaa

cggg

ccca

ccca

cacg

ttgta

tattc

agag

agag

agag

ggag

tcaa

ggtg

tgac

cgtc

gacc

acag

ccag

tgtc

aggc

ctct

gcct

ctgg

gcct

ttgct

ttgtg

gcct

cact

gcaa

caca

aagc

tcca

ccag

gagg

ctgg

ttcac

gtcc

ccta

ccac

ggaa

gcga

ggtc

ccag

aagg

ccag

cggt

ggttc

cagg

agca

acag

ctcc

caaa

ccct

gagc

aagg

caac

cgat

cgcc

agga

ccag

gaag

catc

accc

agga

gattt

ggcg

ccca

cttc

852

3837475

GLTSC

YE<

cgga

gcttc

ctac

aatc

catc

ctttg

aaga

ccac

R2

853

2802804

—NO

tcga

gtac

tatg

tcttt

tgtg

gcac

tgaa

acct

tata

acac

tatg

atag

ctct

gcttc

caca

gcag

tgaa

aacc

gaaa

gagc

cggg

ctgg

gcac

ctgc

ctct

ttga

ggtg

gaac

tcgg

gtca

g

854

3410550

NO

atat

ctcg

tcta

accc

ctac

cattg

tgcc

tggc

ccttt

gaaa

tgtg

tttct

tgct

gacg

tgct

tgttt

ctcc

t855

2808525

...

NO

aaac

agag

tagc

agttc

agcc

ctta

tttgc

cttc

aaaa

aaag

aaaa

gtac

aaag

tgttc

tcta

attc

tggc

tttta

gaaa

gttc

tagg

aagt

taaa

tgaa

cact

tttttt

tcac

tatg

aatta

tatg

agtg

aattc

atca

gaac

ggct

gcttc

taag

aagg

atttt

ggtg

gtttt

agaa

aggt

aggt

gttta

ttcct

ttgcc

tggg

aagc

ctca

cca

gaga

tgttg

actc

taca

accc

atct

cattc

gtta

gtttt

tgtg

gaca

gcag

ttgcc

tcat

cggg

aattt

tttttt

ttcac

ttcct

tacc

atgt

ttccc

ttcgg

atgg

atag

acta

gcc

856

3484

743

—N

Oat

ttaca

cttta

acaa

cttg

ctgg

gaat

ttaaa

caac

ttgct

ggga

acat

ccttt

gtga

ggca

ctgt

agcc

tttttt

tattt

gaaa

ctac

ttaaa

ctcc

aaga

cagg

ctc

acta

actc

tttttc

aagt

gcaa

caac

aaat

gtgt

tagc

tgaa

aata

gcta

attta

atga

ttattt

gtga

caca

gaca

cgat

tatg

tgag

ccaa

gaga

857

3765

643

INT

S2N

Occ

gaag

gattt

tgca

gtcc

tctg

tcag

taac

ttcca

ttgat

tagg

caga

cata

ttcag

gtaa

accc

taat

catta

aaaa

aaaa

ttatc

aatg

taga

aagt

aattc

cct

tttttc

tctc

tgag

atat

acct

caat

caca

cact

tccc

cacc

ccca

cttg

aaac

agac

ctct

tcac

ttgtg

tttttt

tttttt

ttttc

ctga

ggtg

gagt

cttc

ccct

gtt

gccc

aggc

tgga

gtgc

agtg

ggat

gatc

ttggc

tcac

tgca

acttc

tgcc

acct

gggt

tcaa

ggga

ttctc

gtgc

ctca

acct

cctg

agta

gctg

ggac

tgc

aggc

acgc

gcca

cctg

tattt

ttgta

ttttta

gtaa

agac

gggg

gtttg

ccat

gttg

ccca

gact

ggttt

tgaa

ctcc

tggc

ctca

ggtg

atct

gccc

acct

tggc

ctcc

caaa

gtgc

tggg

atta

cagg

tgtg

agcc

accg

cacc

tggc

caga

ccgc

ttcac

ttgta

aaag

aaat

tagg

ctaa

taag

aagg

tgta

gtttt

tgag

aaat

gaaa

tttaa

cttta

gcct

tttca

ctag

taaa

tagt

caca

tctc

atttt

cttc

ctttg

taaa

atgg

ggtta

ctac

tggc

ccta

cctc

atat

tcta

tgag

aatg

agttt

gtag

ctgt

ttcaa

atca

tgaa

gtgc

atag

tatc

acat

gtga

taga

atat

ttata

acttt

ttatta

gatg

ctta

atgt

tcaa

ttaag

taat

tttga

tgtg

aaaa

ataa

aagt

aata

aaag

tatc

ttaaa

aata

gcat

aaga

atttt

cata

ttttta

aaca

aggc

agttt

tgta

gtcc

ctta

agat

taaa

taca

actg

ctcc

tttttt

tttta

aact

gagg

ccttg

cgat

atttt

gtg

858

3810029

—NO

ctgg

tctc

agct

ggac

tatc

gctg

aaca

gagg

cgttg

gccg

caca

tccc

cttg

gaag

gact

ctttg

cttc

caca

ttcgg

aaca

ctgt

cctg

ct859

2658003

—NO

cttg

aaat

ttgag

caca

tccc

actg

tatta

tttca

ctgt

atgg

caaa

agtg

aagg

aggt

aggc

atgt

tctg

tcat

cctta

atta

agct

ttggg

ctgc

ttattg

aagt

atc

atttt

ttcta

taga

ttgga

acat

ggttt

atat

agca

gact

atct

tgtc

cact

gaca

ttgcc

cagt

actg

agttc

c

860

2788748

NO

atgt

agta

cattt

atgg

gctg

tgat

861

3242486

__.

NO

ctca

gcta

ctta

ggca

ggag

aggc

a862

3540024

MTHFD

YES

aggg

gagt

ggat

caaa

cctg

gggc

aata

gtca

tcga

ctgt

gg1

863

3439941

—NO

tgttg

ggaa

gcag

caac

aatc

agcc

atac

agct

ttcaa

g864

3457676

CNPY2

YES

ttgtg

gagg

aata

cgag

gatg

aact

cattg

aattc

ttttc

ccga

gagg

ctga

caat

gtta

aag

865

3843592

NO

gcct

ggcc

agttg

taac

tattt

atca

ctgt

ctgg

actc

ataa

acat

tttga

gatg

acttt

ggga

gtgc

ctgg

ggag

tttca

ttcag

cctg

gtgc

atat

gggc

agtg

aaaa

atat

gctc

atct

gtga

tagt

agat

gtgg

tttgg

ttcac

aaat

ccag

gggc

tggg

cttta

aacg

gcat

tagg

tgga

caga

ggag

ggttg

ctac

agct

gag

gtct

cagc

tggt

gcag

caca

aaag

tgaa

atag

ggcc

atgg

ctat

ctga

agcc

atat

gtgg

ttctg

tgtg

gcta

tgga

gtca

ttcca

ggag

acgt

tcac

agga

tga

tttgg

gatta

ccac

tgct

attg

taaa

ccat

ggaa

attc

tgtg

ttaat

attg

gatg

ctat

ttgta

tttgt

caag

cata

gtct

ggat

gctta

tcca

cattt

tggt

ataa

ggc

caga

attg

aagg

ccca

atat

gatg

tgtc

acttt

gaca

tcttg

tgaa

agtg

ggac

aacc

ttaaa

aggt

gtga

gtac

aaat

ctca

ttccc

actc

tgct

ctct

tga

ataa

tgta

tcct

agcc

taac

agcc

cgttt

tatc

aagg

tgat

aagg

cagg

gttc

cagg

ttgtta

tattt

tgtg

gtgg

gtttc

aattc

catc

ccta

ccag

caga

gtta

tgg

aaac

aaac

cattg

cata

ttccc

aagg

gaat

catg

ggcc

gtta

ta

866

2518951

NO

gcaa

ccct

gcag

tggt

agta

gtgg

tg867

3187461

NO

cctg

ggaa

tattg

gcgc

taga

gaac

agtg

atat

aattt

gagg

tgtc

taca

aatg

ttgtc

taaa

aaac

ctct

ctcc

tctc

atcc

catg

tttcc

tctg

ttctc

tact

ctta

aaat

ctag

gtat

cact

ggga

agag

taac

gcac

tagg

ccca

cagg

acct

tagt

atta

atat

aaat

gagc

tttag

ttttc

aaat

gtca

tttttt

tctc

tata

actg

gag

aaat

tcca

ttaat

aaaa

gaac

ccta

gggg

atag

aggg

taga

ggga

gcga

gagg

ggag

taag

ggag

gaca

cgga

cata

ctta

acac

tacc

tagg

gcac

cta

acca

tcag

aaat

g

868

3730738

—N

Ogg

caga

taaa

gtac

ccat

acta

aaaa

gatg

tcttt

agct

tggt

tgaa

aaat

aattg

tcag

tcct

acca

ctgt

gagt

tcaa

agaa

ctta

agaa

aata

caga

acttc

aagc

agag

atat

agag

gattg

869

2898998

SLC

17A

YE

Sgt

gaga

agag

atac

attg

tgtg

ttc4

870

3397924

RICS

YE

Sat

ctaa

agag

ctgg

tcta

cctc

gtgc

agat

tgct

tgtc

ag871

2494772

___

NO

taaa

tgac

tgtg

gact

agtg

cgcg

tttttt

gtttt

cag

872

3322617

___

NO

catg

accc

accg

taca

tgca

tggg

catg

atct

gattt

tttttt

taat

taaa

gttg

tcac

agtta

tcaa

agtc

tcat

ta873

3735156

___

NO

taaa

attg

aaat

gcag

gttg

ggca

c874

2346360

NO

gtat

tctc

tttca

tgtg

gtca

gtgt

atga

875

3757401

NO

cacc

agttt

agcc

tttga

gtgt

gcag

agct

ctgc

cctc

cctc

ccac

ccct

cagc

ccca

aatc

caag

atttc

atag

ccct

aaca

ccca

ccca

agca

gcttc

cct

caca

catg

ccct

ttgttt

tcttc

ctct

cttc

tatg

gttc

ctta

ggga

aagg

agcc

ttcttt

aggg

atga

aaag

ctaa

ctac

agcc

cagt

ctgg

cctc

cagc

agcc

cag

ggtc

agct

cagc

ctcc

actg

gagg

cgag

ggag

gagg

gcaa

aggg

catg

ggag

aggt

aggg

ctgc

cctc

cagg

agcc

ttccc

cttc

ccta

ggag

ccag

tcag

gattg

ggga

ggaa

ggca

gagg

ggtc

ctag

ggag

ctgt

caca

taga

ggaa

aagg

ggct

ggga

gtgg

ggat

gaca

agaa

gtac

aaag

aaag

aga

aagt

ttggg

gaga

tgga

taac

aagc

tcag

ctgt

gtca

gtga

tgtg

gagg

ggag

gtat

ggtg

gggg

acca

gcca

tggc

ccta

tcca

accc

cagg

ctcc

acag

gccc

caaa

ttggc

tttgc

aaat

ccaa

acat

tttaa

ggaa

gtgg

tttag

ggat

ggaa

gaga

aaca

cggt

agag

gtct

gtgc

tgtg

gattt

tcat

ctag

ggtg

gtgg

gaac

acca

gaga

tgtc

tcct

ctgc

cattg

tttta

gttg

gctc

ctgg

acct

catc

ccag

caga

ggga

gggt

gact

gtca

gcag

gtca

gtcc

cacc

gcca

ctgt

cccc

ctcg

cagt

gggc

ctct

gtgt

ctca

ggcc

tggc

cagg

ctcc

ctgc

ccct

caga

gctc

ctcg

tgga

cccg

ctcc

tcgt

cctc

atct

gact

tcag

cttg

agct

cgtc

gact

gtga

tcttg

ccgt

cctg

g

876

2386

080

—N

Ogg

gcgc

tttta

tgag

gcat

gagg

gagg

cttg

atag

gggc

tttga

aggc

actg

atgg

caat

tggt

gaag

taga

ctttt

atct

aaag

gggg

caga

ga87

730

1360

8__

_N

Ottt

gcct

cttc

gagc

ttggc

agtg

cgag

ccac

aga

878

3460

675

___

NO

atga

acac

tcgc

aggt

ggtc

aggt

g87

925

6460

1M

RPS

5N

Oca

cagc

ttggg

atgt

tacc

ttgcc

ttttg

t88

029

3937

4SL

C22

AY

ES

tgat

aatg

cctg

gaag

gtcc

atat

cgct

aagt

tctc

ctta

ctgg

ttgga

ttaat

ctttg

gcta

ccta

ataa

ctgg

atgc

attg

23

881

3320

209

___

NO

ccac

catg

attg

tgct

tgcc

ggga

g88

238

5262

7L

PHN

lY

ES

gtgt

aaca

accg

cacc

cagt

gcgt

ggtg

gtcg

ccgg

ctcg

gatg

ccttt

cctg

accc

ctgt

cctg

ggac

ctac

aagt

acct

ggag

gtgc

agta

cgac

tgtg

tccc

883

3349

758

—N

Oaa

acag

gcca

tgtg

actg

agga

gcag

gtag

cattc

atat

tattc

atat

ttcga

gcttg

gtag

atgt

agaa

ttttg

cagt

ggag

gcca

ggag

agga

tgtg

agag

ctgc

agga

caga

ggca

tagg

tttttg

gagg

tggt

tgtg

gtgt

tccc

cgat

ggca

atca

acttc

acgg

agag

aaga

ggtta

ttttc

tact

tagg

ttgcc

tgga

gcet

a88

434

2750

3N

Oag

gtcc

ttcag

gtgc

catta

atttt

tcttg

ttattc

aaca

cata

ttattg

agcc

tctg

taat

gtcc

tagg

cttg

ttcaa

gatg

ttcag

aata

aagc

agtg

gata

gaac

aggc

tttaa

agcc

ctgt

acttt

attg

ccca

agtc

aacg

tcct

taga

atac

aggt

acct

caca

acta

ccttg

aggc

tttta

ttatg

ttattt

tcttc

tgca

ttcag

gaat

tcc

ccag

agcc

aata

ggat

acaa

tttta

aaat

gtca

aacc

ttttta

gatc

tcat

acca

tttgg

cttc

agtc

cttc

tttcc

aact

gtat

cattg

tcta

tttct

aaat

aggg

atg

gtct

acac

tgta

aggc

tgat

ttgct

cattg

cccc

caca

aaat

ttgtc

ttgca

ttttc

tctg

ttcat

tcct

gcac

ctga

aata

atttt

gcca

ctgc

cttc

tcaa

agcc

ctca

aacc

ttcaa

tgtc

tggg

tcaa

agcc

gttg

gctc

ccag

gaag

cctg

tttta

gaaa

ttaaa

tccc

caag

ttcttt

tatc

tgca

ttgat

tattt

aaca

cctg

acag

ttg

caac

aact

aaga

tgat

ttgag

cgag

ataa

tgct

ccac

atttt

ttacc

gtgt

ctgt

gtttg

tagg

tgtg

ccca

actg

acat

actg

gcta

agag

ttcag

ggtc

cca

885

3835463

NO

gtcc

tgga

tcat

caac

ttggt

taca

acat

ggtg

ttaac

atgt

ggga

ctga

ttgtg

tttct

tgtta

atat

ttctg

tttct

ccca

acca

cgct

gaat

att

886

2809576

NO

tcaa

atct

atgg

ctta

ccag

agag

aaga

ccag

agcg

caat

atct

ccgt

ggcc

ttagt

cctg

act

887

3601075

NO

atgg

gcca

aagc

tggg

gcac

agga

aa

888

3864620

C19orf6

YES

gact

tatg

ttttc

cggg

ccca

gagc

gctg

aaat

gaag

gaac

gagg

gggc

aacc

agac

cagt

ggca

tcga

cttc

tttat

tacc

ca1

889

3888182

CSElL

NO

ggaa

gttc

tcct

tttga

acttg

tcac

gaat

tcca

tcttg

taaa

gg890

3558243

RIPK3

YES

cttc

ggga

tcct

aatg

tggg

cagt

gct

891

3702633

___

NO

tttac

tcct

aagc

acca

gtga

tgac

ctcg

tcaa

gcag

ggtg

ggct

gcag

ggag

atga

cagc

gggt

atga

aagg

gtgt

ga892

3433106

NO

tagc

tcaa

tgca

accg

acgt

ttctg

agcc

ccca

gaat

ctga

tcca

gatc

ccgg

acat

ataa

acca

cgcc

aaga

agac

aggg

gctg

tctc

tagc

acat

tctc

tcg

aggg

agtc

cggg

gccc

cttc

ccag

acgc

aact

gcaa

aagg

aagg

gcta

acgc

catg

gcgg

gccc

gtgg

tttat

tttat

atcc

gaca

aagt

gcac

ggc

agcc

tgaa

ctgg

actg

gaat

gaaa

agac

gtgt

ctgg

gacg

ggtc

tacg

ggga

cgcg

ctgc

ggga

cctg

tccg

gcttg

gcttc

caag

ccgc

taac

caac

cgc

tgga

tgct

ctgc

agttc

gctg

gtgg

ccgc

ctct

ttctc

cgcg

caga

gtttg

ggcg

acaa

893

3544

695

TT

LL

5Y

ES

gggg

cggg

gcgt

ctac

ctga

tcaa

caat

894

3219

716

—N

Ogt

ggca

tctc

tgct

tgga

agtc

ctat

tctta

gtct

cagc

ttcag

taca

ccct

caag

ctat

ctta

tttgc

ttcta

aaaa

tctc

ttcta

gtac

ttctg

tttca

gtct

ttgta

tagt

tcct

atct

gttc

tttgg

atat

taat

tatg

tata

gtca

cgta

tata

tact

gtgc

agac

ttattt

agag

gcttt

ttgtc

atat

tttgc

ttaaa

cctg

ctac

tgtg

caat

ctta

cattc

cagt

tcttt

catta

gtat

ggtc

tttttt

tttcc

tttct

cctc

tcttc

taca

cttc

tattc

tact

tttcc

ttcttg

gtcc

ctttg

cgta

gcat

ctttt

gcct

ggcc

atct

cagt

tttat

ctttt

aagt

ccttt

ttcttt

gttc

atcc

cctg

cttc

agtg

agct

tttgc

ttctc

tgaa

ctttg

ataa

caag

tatta

ctga

acca

tttat

ttctg

ggtg

taga

attc

atc

caaa

ctga

gcttt

tgag

ggaa

cctta

ttggt

tatc

taat

tcat

tctc

ctgg

ccag

taca

gctg

tcat

tctc

tgaa

acat

ccat

gaca

gtat

ctac

ttgaa

tgttt

aatg

gaca

tctc

aaat

gtaa

cgtc

agag

actg

aattc

caga

ccttc

ctcc

agttg

tctg

ttcttc

tcat

agtc

895

3442

242

ZN

F384

NO

aagg

agaa

ggaa

taag

acgg

cagg

agg

896

3293

761

—N

Oac

cctc

ctta

ccttg

tcct

taga

tgct

taac

atttt

tgttt

ggttt

tctta

taaa

aata

acag

atct

tatg

aagg

taga

ggtc

agat

gctg

aatg

agcg

tctg

gcaa

aag

tggg

atct

gagc

agct

gatg

cggg

ctgc

cagg

gcca

agcc

aagg

ttgtc

ccca

aggc

ctgg

ccttg

gagg

gtcc

cccc

cgac

cggc

cctg

tccc

tgcc

cttg

ctcc

ctgg

gagg

ggac

ggtg

gatg

ggtg

ctgc

tcac

accc

acaa

ggct

tccc

tgtc

tagt

caca

gctc

tgtg

atct

ccag

gggg

gtct

ccat

gatc

acgt

cgcg

aa

897

3829701

GPI

YES

ccca

ggag

acca

tcac

gaat

gcag

agac

ggcg

aagg

agtg

gtttc

tcc

898

3539958

SYNE2

YES

agtg

agaa

ctac

agaa

ggcg

agga

gg899

3620286

EHD4

NO

ccct

atat

tattc

tatc

cgtc

ctcc

ag900

3621069

___

NO

atga

atcc

acct

aaaa

gggg

caga

ggca

901

2496816

—NO

ccac

ccat

ggga

agct

gatg

agttt

tgtg

tattg

aattc

gaag

agca

gaga

atgg

ggga

aaag

gaga

ttccc

ccat

tgaa

aacc

taga

taat

gaga

gagg

cgg

aacc

aaaa

gcag

actc

agaa

cttc

actg

agaa

taat

gggg

gtgt

agta

gtca

ggtg

agag

agac

tgga

ctac

caaa

tcat

cgttg

ctat

ccag

tta

902

2644239

NO

tgaa

gacc

agtc

gaag

gagt

gcag

acca

ggaa

aagc

ggga

cgttg

atttg

gatg

gga

903

2832085

ZMAT2

YES

tgga

ctttc

gccg

aaag

tggg

acaa

agat

gaat

atga

gaaa

ctcg

ccga

gaag

aggc

tca

904

3757844

STAT3

YES

tgct

gaac

cctc

agca

ggag

ggca

g

905

2943556

—NO

cctc

atct

gctc

ctac

tacc

ttgca

906

2459948

—NO

aaac

ttttc

tcga

tacc

cttc

tgtg

atga

ctt

907

3119958

GRINA

YES

ctttg

tccg

ggag

aatg

tctg

gacc

tact

atgt

ctcc

tatg

ctgt

cttc

ttcat

ctct

ctca

tcgt

cctc

agct

gttg

tggg

gact

tccg

gcga

aagc

ac908

2567115

—NO

cctg

atta

gcat

atca

cagt

gctc

tagg

agtc

ctgg

aacg

ccttc

ctct

tcca

tgtg

cact

gctg

ctga

catc

cagg

ccat

tttgg

aacc

tgca

aatg

tctc

ttcc

c

909

2893649

—NO

taag

tctta

gtaa

ctcc

gtgc

tgga

tgtg

cattt

tgca

ttcag

cttc

tttat

cata

aggg

agga

acaa

agac

tggg

gctc

ctgc

tgac

atct

gcag

acac

aaag

ctga

gtcg

gaat

ttgtg

gtct

tagc

ttcgg

ttcag

cacc

aagt

gtat

ttata

agttt

gcag

tcat

aggt

tttgt

tgtc

caaa

tccc

aaca

aagc

ccttt

ccca

cctc

cac

ccca

cccc

ggaa

gtta

tata

gggt

tcct

tgaa

ggga

caaa

gcct

ctag

aaaa

agaa

aagt

cact

gaaa

gttg

taat

gtga

aacc

agca

aaga

gaaa

ata

catg

tttgg

tttag

ttgtg

gtca

cagt

ccat

ggtg

910

2346547

—NO

ccct

gaca

gatc

tcgg

tctg

gggc

acag

ga911

2852745

AMAC

NO

ctgg

agct

tccc

tgga

ctca

acttc

ctaa

aggc

atgt

gagg

aagg

ggta

gattc

caca

atct

aatc

cggg

tgcc

atca

gagt

agag

ggag

taga

gaat

gga

Rtg

ttggg

tagg

ccat

caat

aagg

tcca

ttctg

cgca

gtat

ctca

actg

ccgt

tcaa

caat

cgca

agag

gaag

gtgg

agca

ggttt

cttc

atct

taca

gttg

aga

aaac

agag

actc

agaa

gggc

ttctta

gttc

atgt

ttccc

ttagc

gcct

cagt

gattt

tttca

tggt

ggct

tagg

ccaa

aaga

aata

tcta

acca

ttcaa

tttat

aaa

taat

tagg

tccc

caac

gaat

taaa

tatta

tgtc

ctac

caac

ttatta

gctg

cttg

aaaa

atat

aata

caca

taaa

taaa

aaaa

tata

tttttc

atttc

tattt

cattg

ttaat

caca

acta

ctta

ctaa

ggag

atgt

atgc

acct

attg

gaca

ctgt

gcaa

cttc

tcac

ctgg

aatg

agat

tgga

cact

gctg

ccct

cattt

tctg

ctcc

atgt

tgg

tgtc

cata

tagt

acttg

atttt

ttatc

agat

ggcc

tgga

aaac

ccag

tctc

acaa

aaat

atga

aatta

tcag

aagg

atta

tagt

gcaa

tctta

tgttg

aaag

aatg

aac

tacc

tcac

tagt

agttc

acgt

gatg

tctg

acag

atgt

tgag

tttca

ttgtg

tttgt

gtgt

tcaa

atttt

taaa

tattc

tgag

atac

tcttg

tgag

gtca

ctct

aatg

ccc

tggg

tgcc

ttggc

acag

tttta

gaaa

tacc

agttg

aaaa

tattt

gctc

agga

atat

gcaa

ctag

gaag

gggc

agaa

tcag

aattt

aagc

tttca

tattc

tagc

cttc

agtc

ttgttc

ttcaa

ccat

tttta

ggaa

ctttc

ccat

aagg

ttatg

ttttc

cagc

ccag

gcat

ggag

gatc

acttg

aggc

caag

agttc

gaga

ccag

cctg

ggg

aact

tggc

tgga

cctc

cgttt

ctac

gaaa

ta

912

3659

213

NO

acct

ccaa

ggtta

cagc

acttt

ctaa

gaat

gtgc

ctat

gtag

catg

tctg

tccc

ccca

ctgc

ctcc

acca

aaat

tctg

agaa

caaa

gaca

ctgt

aggg

attg

aacc

tgaa

gagt

attc

gctg

gaat

ggta

tgct

aagg

tttct

ttcct

gctg

taca

cctc

ctct

gccc

caac

aagg

tgct

ttaag

ttctg

tttttt

aattt

agga

aacc

tgtt

ctgc

tatta

taga

aggc

catg

aaaa

gaga

ccag

tgat

ttatc

taat

cata

agca

aaaa

tagt

agaa

ggct

attg

tcttg

tcac

ttaag

ttgaa

tgaa

tccc

agtg

attg

tagt

tgct

tcac

gaaa

aata

acca

atttg

ttcta

caga

ggta

gtct

gttc

ccag

agat

tgaa

aaaa

aaaa

agat

gtag

gaaa

gttta

aata

aata

aaat

tgt

ttaaa

ttcac

aatg

gagg

gcca

attc

acat

ggcc

ctct

gcat

tttga

tgta

attc

taac

agttt

tact

agca

gaat

ctaa

caaa

ttttg

aaag

tcag

agcg

tatg

tata

gata

tata

taca

catg

caca

cattt

tttta

atga

tacg

ttatc

cact

taaa

aaaa

aaag

tctc

aaga

atgt

cata

agaa

actc

cctta

acct

caat

gagc

ctca

ggt

ttcta

atcc

ctaa

a

913

3296

517

POL

R3

NO

ctca

tgta

acct

ggga

agag

ccat

aaag

gggt

accc

ccca

cccc

aact

gcct

tcct

ggaa

gcat

gcct

ggga

agta

agct

gtag

gcct

gatc

cgag

ccag

Aga

ccac

tggg

atcc

gtgc

aaag

gcca

gggg

aggg

taga

attg

aatc

atag

gagt

gaac

tccg

gcac

ctgt

tgtc

ttctg

cggg

tgac

gcac

acttt

aaat

gg

914

3028090

—NO

cttg

gtcg

tcac

attc

tgct

tttag

915

3291113

—NO

aaga

tcttt

gagt

tgta

cttg

gtgt

gtgc

tgttt

ttgttt

gaga

tgca

gtga

atgt

gcaa

atag

ccca

gccg

taaa

tagt

tact

taaa

ataa

tctc

ttggt

actg

ggt

agca

gcag

taga

aagt

tgat

ctgt

tta

916

3616816

—NO

gggc

cgaa

actg

ctgc

cgtg

catta

gctc

tgtg

gagg

ggag

tcat

aaat

tctg

gttg

tcag

cgttt

tccg

tggc

tttgt

g917

3842744

—NO

ctcc

atat

atta

gctg

gggc

tgcc

ataa

caaa

acat

cata

gact

gggt

ggct

taaa

caac

aattt

acttc

tcac

agttc

tgaa

gtct

ggaa

gtct

gaga

acag

gtc

gcca

gcat

ggtta

ggttc

tcgt

aggg

ttctc

ttcct

gttc

918

3956320

PITPNB

YES

tccc

gagg

gctc

cttg

gtgt

ttcat

gaga

919

2473315

—NO

ctgg

gctg

ccaa

tctc

ttgcc

ttggg

ggca

gagc

ctca

tctc

tctg

gcta

ctgg

ggtta

gcta

ccttg

ttgga

gctg

gcaa

agcc

attg

gtgt

tgac

atcg

gggg

tgac

tcct

gaag

ccgc

cata

tacg

tgct

gcca

atgg

ttttg

atct

tggt

gatc

accc

ggaa

cttg

ggat

tgtc

cagg

agct

gagg

ccag

gattc

agga

aaga

attg

tcag

cagt

caag

ggag

agga

atga

ccca

accc

agtg

acag

atgt

acct

gttta

caag

gacc

ccac

taaa

ccca

agag

acac

tttcc

tatc

aaag

ttgt

tact

tagt

ctac

cgct

tatc

tgcc

acat

gatc

ctgg

gaga

acttc

920

2659117

NO

tgcc

taca

tgct

ccttc

tagc

tttgt

ttccc

tgat

gttc

cttg

ccac

ctgc

tact

cctc

tctg

agct

acttt

tcca

ggttc

caca

ggga

gagg

ttcag

ctgt

ccgt

ggta

gaca

tgag

ggta

gaga

atga

ggtg

gttg

ggttc

cact

tacc

tttct

atca

tcttg

cagt

atgg

atgt

ctct

tgac

tggt

accg

tgta

921

2826873

NO

gata

tttat

ttggg

tgca

tgttt

cct

922

3498544

—NO

tggc

gtct

gatc

agga

aggg

actc

tgct

gcgg

ctgt

ggat

ctga

cctg

ggta

tcag

atgg

tgat

gcttt

gtaa

atag

tgtg

cctc

atag

gggt

ctgt

tctta

gtt

aaaa

ggag

cctg

cttg

gtga

ttcct

tttg

923

2756844

SLC26A

YEJ

cagg

ccat

cgcc

tact

cattg

ctgg

ccgg

gctg

cagc

ccat

ctac

agcc

tcta

tacg

tcct

tcttc

gcca

acct

catc

tact

tcct

catg

ggca

cctc

acgg

ca1 1

tgtc

tccg

tggg

catc

ttcag

c

924

3088854

NO

atgt

gccc

tacc

caga

cagt

gcct

g925

3173548

PGM5

NO

cggg

agat

gcttc

actg

atgc

cttc

ttgct

acct

gtttg

tgcc

tctta

tgac

tttgg

aaaa

acaa

aaga

tattt

tgct

tttgg

ggga

taga

gggt

gggt

ggga

aaa

gaaa

aaaa

atcc

atttg

gtttt

ggttt

tgtc

ctat

tcct

ccaa

atgc

agca

gggc

cttta

gttg

tctg

ttaaa

gctg

cact

ataa

tttgg

tatc

taca

tttta

tcac

aca

aagg

aacc

tccc

ctttt

gaca

acaa

ctgg

gcta

ggca

gctg

ttaat

caca

acat

ttgtg

catc

acttg

tgcc

aagt

gaga

aaat

gttc

taaa

atca

caag

aga

gaac

agtg

ccag

aatg

aaac

tgac

ccta

agtc

ccag

gtgc

ccct

gggc

aggc

agaa

ggag

acac

tccc

agca

tgga

ggag

ggttt

atct

tttca

tcct

aggt

cagg

tcta

caat

gggg

gaag

gtttt

atta

taga

actc

ccaa

cagc

ccac

ctca

ctcc

tgcc

accc

accc

gatg

gccc

tgcc

tccc

ccat

ccca

tccc

caa

catc

cctg

tacc

acct

tctc

tcac

atct

tcta

aagc

tttgt

acaa

atca

caat

ggtg

cact

tcca

acaa

aata

tatc

aata

ggtg

ttttc

ctct

ctta

ttttg

taaa

tag

tatta

tttta

gcta

ttaag

ctgg

atac

cttc

tttca

aattc

agcc

attc

agttg

taaa

gttg

ggaa

gaag

tttct

tgac

aaga

ctct

gcaa

ttaaa

tgct

taaa

atttg

gag

ggga

tcct

tcct

tgat

taca

tcaa

gtat

gttg

gtac

atgg

gttta

taca

agttc

ctct

tgag

aagg

caaa

aaga

ccac

catg

tgtg

agag

ctct

ttgac

ttgg

ccaa

tagg

ggcc

tatc

ttaat

gcac

ttgttt

ggac

acat

ttctg

atct

tattt

gtaa

aggc

tgca

aaag

gaga

ggat

gaaa

tgct

gtaa

aagt

agga

aatg

aagt

ggaa

gctg

gaag

aaaa

tgta

attg

gtgg

taca

gcta

tggg

ccag

atgg

tgga

gggg

aggg

tggg

gacc

cctg

c

926

3200

057

BN

C2

YE

Stc

cctc

ccaa

ccag

tccc

atca

ttcca

acca

gtgg

tacc

atag

agca

gcac

cc

927

2974

443

MO

XD

lY

ES

ggcc

atga

gagt

ctgg

tgca

ccac

atcc

tgct

ctat

cagt

gcag

caac

aact

ttaac

gaca

gcgt

tctg

gagt

ccgg

ccac

gagt

gcta

tcac

c92

823

8590

5__

_N

Otc

taaa

aggc

gtgg

aaac

attta

taag

aaat

acca

atta

tgca

gtgt

tggt

gtca

gtgt

ggac

ttaac

tgcc

gaga

ctga

ctta

ttgcc

ag92

936

3956

6—

NO

acag

gtta

tttct

atgg

acag

gctc

ttgac

agaa

actc

tgaa

catg

gata

ttact

gtcc

ccttc

attc

aaat

gagg

ctga

actg

aggc

tcat

aagt

attta

actc

tcac

acct

agtta

acac

agta

agat

ttgaa

acca

gata

tata

tgaa

tcca

cgaa

gtct

tatc

tg

930

3200

565

NO

tggc

atttc

atga

gggg

aggc

ttatc

tgtg

g93

130

8378

1M

CPH

lN

Oat

gtag

tggc

ctat

gttg

aagt

gtgg

tcat

ccaa

tgga

acag

aaaa

ttattc

aaag

acat

ttaca

acac

agct

tgtg

gata

tggg

ggca

a93

238

2937

6__

_N

Oat

ggcc

gtcg

tcag

gagc

attg

tgga

933

2359

017

___

NO

gtaa

ccgg

ggga

tcttg

cttg

tcag

tgcc

tgga

c93

431

8098

2H

AB

P4N

Ogg

ggag

acttt

tcca

gctg

ggcc

aagg

gagt

caga

ctct

aaga

acaa

taga

tgttg

ctttt

cccg

tgtc

atgt

aaat

ttgttg

cact

tttttg

ggct

gagc

tgtta

gagg

ggct

tctc

caga

ggct

cgag

agca

ggcc

atttc

ccaa

gaag

atga

agaa

tggt

gact

gtgt

tttta

ttgaa

ggaa

tttca

aatg

aaga

ataa

tgttt

aaa

atgt

gtat

atag

agat

agta

taga

ctcc

tccg

cgga

agca

tgga

ggga

aagg

aggt

tgta

aaat

agac

tcca

tgga

gact

ctta

ggaa

gcag

taga

ttccc

ggg

ggct

gtgc

cttta

gcgt

taga

ggaa

acac

atag

agct

ggaa

ctgt

taat

ggaa

agca

gtca

cagc

tgag

ttttc

ggag

acca

a

935

3915

249

—N

Occ

aagc

tgta

gatc

ttccc

aaga

tattt

ttcag

gaac

gaag

catg

taaa

ctta

catg

agtg

aaag

acag

tggt

aaaa

aaaa

aaaa

aaac

agtc

tattt

tggg

ctttg

gctc

ctac

ctaa

atct

agct

tgtt

936

3263

765

—N

Otg

caga

gtcc

taca

gctg

gttc

aagg

cagc

atca

ggct

caga

accc

ctttc

tctc

agct

ctct

gttg

tgat

tattt

cagg

acct

tgttc

tgttt

tcca

catg

gcct

cta

atct

agac

acct

gacc

tggt

ggga

gtaa

ccttt

ca

937

3303

272

ER

LIN

lY

ES

ggag

ctca

aaaa

gtac

cagg

ccat

tgct

tcta

acag

taag

atct

atttt

ggca

gcaa

catc

ccta

acat

gttc

gtgg

actc

ctca

938

2683

681

—N

Ogg

tgac

ccag

gcac

gata

gcta

agaa

ggca

aagt

cgct

tgttc

tatta

gctg

tttag

gcat

ctttg

cagc

catc

cttg

atttg

gagt

ttttg

atct

tgat

ctaa

ttct

atcc

ctca

aaac

cagc

cctta

caat

ctca

cgtg

ccca

cctc

ttcca

tgac

agtc

cttg

ggcc

taga

ggga

gggt

gattg

tata

gtttt

agca

gcag

ggca

tttg

cagt

gaaa

aaca

gattg

ggcc

cagt

ggga

tgcc

aaat

gaga

gagg

gtcg

catc

t

939

2683

865

RO

BO

lY

ES

tggt

gtgt

ggct

tcat

acat

ttggg

gacc

ctat

ttcca

ctcc

ctcc

tcttg

gcat

gaga

ctgt

atac

agga

tcca

cccg

ag94

037

8111

6—

NO

ggca

gctg

ccct

gtaa

tgttc

tacc

agta

cttc

agac

tcaa

catg

cacg

aaga

ttaa

941

3050

281

—N

Oat

gctg

ccct

tcga

tgac

cata

gtga

atgt

tcca

caga

gtgt

acta

cgag

ccac

aaac

acca

ggga

gaga

accc

cagc

atca

gtgg

agta

gaaa

caaa

aagg

tgttc

tgtg

tttcg

cact

tggg

tcct

g

942

3903

591

—N

Oat

cggc

atag

ccta

gatg

ggtc

ttctg

tttca

gggt

ctct

caca

ggag

gtag

tcaa

ggtg

tcag

ccag

ggct

ggtg

tctc

atct

tagc

gcttg

gctg

ggga

ataa

tctg

tttcc

aaac

taac

ttggt

tggt

gaca

gaat

tctc

ttcttg

aagg

gatg

ttgaa

ttgaa

gggc

ttggt

ttctc

actg

gctg

atgg

ctgg

aggt

tgct

ctga

attc

ctttc

catg

tagc

ttcttc

aaca

tcac

aaag

ctga

gaaa

ggaa

tagc

aagt

ctcc

tagg

aaga

tgga

aatc

acaa

tttttt

ataa

tcat

ggag

tggc

atcc

tatc

acat

tttcc

atag

tccg

ttagt

taga

agca

aatc

acca

ggcc

agtc

cata

ctca

ggag

ga

943

3115

066

—N

Ogt

ctag

gggt

taca

ggat

catc

atct

aagt

tctg

cttc

tgcc

tgga

cttg

ctgc

gtaa

tttga

atga

gtgg

ctaa

acct

gact

ctttc

tcct

cttg

944

2509

773

MB

D5

YE

Sca

ctaa

caga

aggt

ttgga

agcc

taca

gccg

tgtc

cgga

aaag

gaac

aga

945

2322

410

NE

CA

PNNO

Ottc

tcttt

ggtg

gtttc

taaa

gtgc

ct2

946

2837

342

CY

FIP2

YE

Sttt

tgtg

cgga

ctgc

cattc

ctttc

accc

aaga

acca

caac

gaga

caaa

cctg

ccaa

cgtc

cagc

ctta

ttacc

tcta

tgga

tcc

947

2936

910

—N

Otta

aagg

tgta

gagt

aaga

agaa

tcaa

tacc

gtgt

gttg

gata

ttaag

caat

tggt

aatta

atct

tgct

tcct

ttatc

ttgac

aaga

tgtg

ctttt

tcac

ttac

948

3958

553

SYN

3Y

ES

atcc

ttcaa

gcca

gact

tcat

cctg

gtcc

gcca

gcat

gcct

acag

catg

gccc

tggg

ggaa

gact

accg

cagc

ctgg

tcat

cggc

ctgc

agta

tgga

ggg

ctgc

ctgc

tgtc

aact

ctct

ctac

tccg

tc

949

2901

722

NO

acag

taat

ggaa

gacg

ggag

ttgca

gtgc

tcag

tcat

ggaa

ttcct

ccta

950

3092

902

NR

Gl

YE

Scc

aaat

gagt

ttact

ggtg

atcg

ctgc

caaa

acta

cgta

a95

124

3710

2K

RT

CA

NO

tgcc

acgt

gctc

agaa

attc

acag

caga

tgca

atct

catg

taaa

accc

tcat

gtgg

taaa

acaa

agat

ctat

catg

gttg

ccct

taat

ctttt

ctct

tttttt

tttttt

ttP

2ttt

ttttg

agac

aagg

cttta

ctct

gtcg

ccta

ggct

ggag

tgca

ggga

tgtg

atca

ctga

agcc

ttgac

ctgg

tctc

aagc

aatc

ttccc

tcct

cagt

ctta

cca

gtag

ctgg

gact

acca

gtga

gtgc

cacc

acac

ccag

ctac

tgttt

taag

tttttg

taga

gatg

gggt

ttcac

caca

ttgcc

cagg

ctgg

tctc

gaac

tcct

ggg

ctca

agtg

atcc

tcct

atttc

agcc

tccc

agag

tgct

ggaa

ttaca

ggtg

tgag

ccac

tgtg

cctg

gctg

ccct

cattt

ctttg

cccc

cctc

tagg

acttg

ctttc

tcc

gcat

agcc

ctttt

gcag

gcttc

agag

ttcttt

ccat

ccag

tagc

cccg

ggac

ttctc

tctg

ttagg

ttttg

Ul

952

2657

991

CC

DC

5Y

ES

tatg

ccga

gattt

tgct

gtcc

tgga

gU

i0

953

2520

359

—N

Oct

ttgag

cgat

gaaa

acag

ttttta

tcttt

ttagc

aaag

ttgta

gtta

ggat

cttc

tgtc

tgttt

ttagg

ggtc

tcca

ctgg

tatta

aagg

cctg

a95

425

9227

4ST

AT

lN

Ogc

tgag

gttta

gctg

tcag

ttcttt

ttgcc

ctttg

ggaa

ttcgg

catg

gtttc

atttt

actg

cact

agcc

aaga

gact

ttact

tttaa

gaag

tatta

aaat

tcta

aaat

tct

atta

atct

ctca

ttaat

agta

tttaa

tata

aaga

ttctta

aaat

tact

gacg

ttatg

aattg

gtttg

atgc

955

2681

309

—N

Oat

cttc

taag

tgtc

catg

cagc

ttgaa

tcat

tgca

caca

gtct

tcta

tgag

ttatg

aaaa

taaa

taaa

accc

cctc

ttttc

ccca

tttta

tggt

tgtg

aaac

tgac

acag

ataa

caca

aaag

ggta

gatta

ggga

aagc

cata

tccc

ctct

gcca

ccca

cctc

caat

actg

atcc

agct

ttcct

ggat

cagg

ctag

tagg

gcgt

tgag

gcttc

ttact

agaa

956

2961

267

CO

L12

YE

Sttg

gaat

ccat

ctcc

tagt

ccag

tgac

tggc

taca

aagt

catc

ctca

cacc

aatg

actg

cagg

aagc

cgac

agca

cgct

ctga

gtgt

gggg

cctc

agac

aaA

lcc

acgc

tcag

tgttc

gcga

cctc

tcag

caga

caca

gaat

acca

gatc

agtg

tttcc

gcca

tgaa

957

2854

242

RIC

TO

NO

ggct

gcat

ccta

ttacc

acaa

tggg

gtgt

gcta

taac

tgct

ggta

ttaga

gagg

gaac

tttgg

ccct

ttcac

gtttt

tctta

atgt

ttgta

acac

tact

tcag

aggt

tR

tata

acct

caaa

gcag

aaga

agag

cctc

aaca

accc

ggga

ctta

taag

ttattt

ttatg

ttact

agac

ttgca

taaa

gattc

ttgttt

tcca

actc

ttcat

tttgt

tgc

aatg

tgtta

ttaca

ggat

atat

gaac

caat

taag

gtttt

tcac

taca

gttc

ttgaa

taaa

attta

aaaa

tcat

ttttta

tttta

atta

aaaa

tattt

ccca

tttat

agaa

tgc

atat

atttg

caat

ggac

ttcca

ctttc

atca

acttt

ccat

ctca

tcgc

tttaa

acag

gaac

ttgaa

caag

cact

gtta

gttta

gacc

taaa

ggat

agga

aagc

atta

aata

atac

tttgg

atct

cctg

agga

aaag

ataa

gtttg

cttg

caat

ttaca

cattc

catg

ggga

aaga

agag

ccat

atttc

ctta

aaaa

aaac

atta

ataa

agct

tgt

tattg

agaa

aaat

tgta

gtga

aaag

cctta

agta

ccaa

atttt

aaag

cagc

agta

actta

atttt

tata

tcag

tgttt

ttgttt

tgca

caaa

ctaa

atgc

agtg

gta

ggtg

ggttt

atga

gtat

atta

attg

ccttt

atcc

atttg

tgaa

gtta

agttg

atga

gggc

aagg

tttttg

tttgt

ttaat

ttgta

tatg

tcta

aagg

tattt

ggaa

ctttt

taca

ggaa

ttaaa

cata

tatg

caaa

tttgt

atat

aaaa

atag

catg

gcca

tcat

ttgaa

tgct

tgta

aatg

aaag

gatta

tcttt

tttga

gatc

tata

tata

aata

gaaa

tag

aaaa

tcca

gctg

gact

gatta

ggat

tcttt

tttaa

ttcat

ttgtg

tata

acat

tttta

ttaca

atta

caca

tcag

ttttg

acac

agtc

atag

caac

atta

atat

tttcc

cat

gatg

caga

tcct

ttttg

taat

gggc

ttgttc

tttga

958

2957

263

—N

Otg

ggga

ggca

cata

acag

tttttt

attc

tggg

aaga

gcca

gttc

ccca

ctca

acat

attc

aata

ggca

caga

gacc

aggg

gacc

acgg

aaag

ctcc

agtg

acc

cccg

accc

ccgc

caac

tcttc

ctaa

caac

atttg

actc

cttg

ccct

cctc

cgttg

gaac

tgtg

cttc

ctgg

aagg

aaag

tgat

tgaa

gaag

aaga

gatg

tagt

tctg

taaa

aggc

ataa

aaac

agct

tgttt

tttta

aaaa

aata

atat

ttttc

tgtta

tgat

gcaa

atttt

ttcat

gact

cttc

tttct

ctca

ctct

ccac

agtc

atttc

atc

ggca

ggtc

ctgc

cagc

tctg

cctc

ccaa

acac

attg

agac

tgtc

tgct

gcttt

ctgc

ctgc

acca

ccaa

ccct

agtc

tagt

gacc

tttga

ccag

ggga

ga

959

3429

874

OC

C-I

NO

aaca

gaag

aatc

cgta

acag

aaga

tgac

a96

037

6691

5—

NO

ctcc

tcca

ttgaa

gcag

attg

atta

aaac

agct

tagg

aaag

ggca

aact

tgga

tcac

gagc

agtg

gattt

ttttc

atat

ctga

tagt

gaat

ttaac

tttttc

atttc

tgg

cgaa

atta

aaga

gatc

tgtg

acca

aaag

tggt

caag

cact

ggag

tctg

a

961

2691

040

—N

Ocg

cact

ggca

ttgga

acat

aata

aact

aaaa

ttaaa

atgt

ttcttt

actg

tgcc

tcac

cattg

caca

atca

aaaa

aaat

tttttt

gcat

acac

tgtg

gtga

aata

att

tttaa

aact

tgga

cttg

ctac

tgtg

aaga

ctga

tgttt

aaag

tttat

aact

gtat

aaac

atttt

ctat

gtcc

cccc

ccac

acca

tgga

tttct

tata

acat

tgga

tata

ttttt

ccttg

ctgg

acta

ttctc

ttttg

gattg

a

962

2824

389

DC

P2N

Oag

tgca

ctgc

tttct

taca

ggaa

gaca

actc

agaa

caca

cagc

cata

atct

gcttt

ggtg

tcag

tcac

atca

cagt

ggtta

taca

tttgt

cctg

aatg

gtga

ttca

ttcct

ttcca

tcta

acttc

cttg

tgac

aaat

agca

tttac

tattg

aaat

agtc

ttaaa

atag

ggaa

aaga

gtga

aagt

tact

ctta

tgca

tggg

agtg

ggct

taaa

ggg

ttgac

ttcca

ccag

ctga

gtac

aaac

aagt

gtaa

agaa

aaac

tatg

ataa

agta

tgga

ggtc

ttgag

aattg

ttcat

aatg

aaat

cttta

atct

gggt

tatc

aga

gtaa

tgaa

atca

ccaa

taaa

aaca

ttcca

tttat

cttg

gatc

ttctg

tggt

tagc

agag

gagt

atgg

tcta

gcta

tgtta

gcag

cttg

aagg

caca

acgt

aaa

agga

atga

gcttt

caca

aggt

gctta

cgtta

gctg

ggta

gtat

tggt

caaa

ggta

ctct

gaag

agtg

aatg

caga

aatc

agttg

gctg

tgttt

gtaa

tcttg

tcc

caca

tgga

ccct

aacc

tttag

taga

cttc

agtc

tttta

gtcc

agta

gaag

acaa

tggc

cctg

aata

tgtg

ttttc

tgct

ttttg

gtgg

aagg

tttcc

tgca

ggtg

gtt

gggt

ggttt

ttggg

ttattg

gcta

ctgt

tcgt

tcag

tgcc

atttg

aaga

cctg

ttgttt

ctta

atcc

tttttc

ttggt

gtga

ctgg

ccag

gaaa

aagt

ccat

tgag

tcct

tttttt

ctcc

ctgg

tgtc

ttacc

ccttc

tgta

gaat

aatc

cata

tttta

aaat

ttgttt

caca

tcttt

atag

caaa

cctg

ccac

agac

ttgca

agca

gtga

tttta

tcttt

cct

tcct

gaga

aggt

gatc

tcac

ttttg

atgt

ttggg

tcac

ctgt

ggac

acct

gtgc

tcttt

tgag

tctc

aagg

ctta

tagc

tttca

cattg

gcttg

ggaa

caac

aga

cttg

tgtg

tggt

tcta

gagt

gaaa

tggg

cagt

gttc

tgct

ggtc

ctca

gtct

ttgag

ag

963

4054

485

GA

BR

DNN

OO

ctct

gcag

gatc

ggga

tcag

agcg

tggg

agga

ggtg

gggg

tgga

cgtc

catc

cggt

gaac

agtg

a

964

2871

027

EPB

41L

YYEE

SScc

cggc

ctga

tcag

aatg

tgac

aaga

agtc

gaag

caag

actta

ccct

aagc

gaat

agca

caaa

caca

gcca

gctg

4A

965

3468

170

—N

Ogc

tgag

ccca

taac

ctgc

gtct

tctg

ctct

agcc

tcttg

tctg

tctc

attc

ctcc

tctg

catg

gattg

tctc

tattt

ggaa

ggtc

cgtg

gtttt

tatg

tgta

aaat

gaa

agct

gccg

tgttc

ccttt

ccaa

cacc

aagt

ctag

ttctc

tagc

tccc

attc

tatc

agtg

tcat

acct

ccca

gctta

a

966

2739

471

EN

PEP

YE

Sga

tact

gcat

tcaa

acga

aaca

tgtg

gcca

ttctc

tgtg

cggt

ggtg

gtgg

gtgt

agga

ttaat

agtg

ggac

ttgcc

gtgg

gct

967

3725

508

___

NO

ccag

tgct

ttgca

ctgt

agct

gctc

aata

a

968

3946

498

MC

HR

lY

ES

ttcgc

ggtc

gtga

agaa

gtcc

aagc

tgca

ctgg

tgca

acaa

cgtc

cccg

acat

cttc

atca

tcaa

cctc

tcgg

tagt

agat

ctcc

tcttt

ctcc

tggg

catg

ccct

tcat

gatc

cacc

agct

catg

ggca

atgg

ggtg

tggc

acttt

gggg

agac

catg

tgca

ccct

catc

acgg

ccat

ggat

gcca

atag

tcag

ttcac

cagc

acct

acat

cctg

accg

ccat

ggcc

attg

accg

ctac

ctgg

ccac

tgtc

cacc

ccat

ctct

tcca

cgaa

gttc

cgga

agcc

ctct

gtgg

ccac

cctg

gtga

tctg

cct

cctg

tggg

ccct

ctcc

ttcat

cagc

atca

cccc

tgtg

tggc

tgta

tgcc

agac

tcat

cccc

ttccc

agga

ggtg

cagt

gggc

tgcg

gcat

acgc

ctgc

ccaa

ccca

gaca

ctga

cctc

tact

ggttc

accc

tgta

ccag

tttttc

ctgg

ccttt

gccc

tgcc

ttttg

tggt

catc

acag

ccgc

atac

gtga

ggat

cctg

cagc

gcat

gacg

tcct

cagt

ggcc

cccg

cctc

ccag

cgca

gcat

ccgg

ctgc

ggac

aaag

aggg

tgac

ccgc

acag

ccat

cgcc

atct

gtct

ggtc

ttcttt

gtgt

gct

gggc

accc

tact

atgt

gcta

cagc

tgac

ccag

ttgtc

catc

agcc

gccc

gacc

ctca

ccttt

gtct

actta

taca

atgc

ggcc

atca

gcttg

ggct

atgc

caac

agct

gcct

caac

ccct

ttgtg

taca

tcgt

gctc

tgtg

agac

gttc

cgca

aa

969

2818

169

___

NO

agac

acag

acgg

gtgg

accc

aagc

attg

aggg

c

970

3092

610

UB

XN

8Y

ES

ttttg

ctttg

tggc

cgga

ttttg

ctac

tgct

tgct

cttc

tta

971

2560

754

___

NO

gccc

gcta

tctg

catc

tgcc

ttttg

gact

ccttg

gggg

aaat

aaaa

caat

cgtg

taca

gttg

ggag

gctc

ttcgt

tttca

ccat

cagt

tgac

tcca

tcag

t

972

3850

324

—N

Oga

gttc

aggg

agac

gcca

gaca

attg

cagc

agttt

gtag

agtta

tgtg

ggtc

aggc

tagg

atta

gtttt

gctg

cagg

aata

agca

atcc

cccc

aaat

ctta

atca

aggt

ttacc

taaa

atcg

gccg

agca

ca

973

3209

807

NO

cttc

tctg

aaaa

gacc

agcg

gccc

tatg

acta

tc

974

2639

722

KA

LR

NN

Occ

ttcttc

tcta

ctgg

gtgc

aattc

gagg

ttgct

gagc

ttctc

tcca

aagt

ctaa

aatg

gtgg

ggca

gtag

ggac

ctgt

gaga

ggcc

caat

ggcc

caat

gtac

ttc

cccc

agat

ccca

ctca

gaac

agca

ggta

cgcc

cagg

ctcc

tgct

gccc

taga

ggtc

tgca

acat

gagt

gaag

aggt

taat

taga

ggga

caca

ctta

tct

ctga

agttt

ttctc

cagg

ctga

acat

ttcta

ttatc

agtg

gccc

ctaa

tctg

gaaa

aacc

catc

attc

taat

ctag

cttg

tatc

ccca

catc

atga

gaaa

gagg

gaag

aaga

agaa

ggga

tgat

gtgt

ggta

gaga

agat

gagg

gtta

acttt

agcc

tttcc

caaa

cact

ggca

acaa

ccac

ttcct

caac

aattt

ttcta

tttgc

ttcag

ccta

ctca

gattt

tttca

ggttt

ttcta

gctc

ctcc

ataa

cctc

actc

cctc

ccga

ggtc

tctg

gttc

aaag

acca

ccct

acca

gccc

ctat

ttgct

tcag

gtta

tcc

tgttg

aggg

tggg

tggg

aaga

gtga

gaag

atat

aaat

gaaa

aact

ggcc

acat

gttg

ataa

ttgttg

aaac

taga

tgat

ggta

cgtg

gaca

ttcat

tata

ccat

tctc

ccca

cttc

tgta

tttgt

ttgca

atttt

tcat

aata

aaaa

agttt

taaa

agtc

ctcc

agttt

ccaa

caca

ctca

agag

agag

cccc

aacc

ccaa

acac

agag

tttc

atgg

aaac

ccca

cacc

aagg

caag

aggc

agag

atga

tgat

tcca

tttca

tata

taca

ctca

ttttc

taac

tttttt

taaa

ggcc

cact

gcttt

atttt

caat

agat

taaa

cctg

atttc

tgag

aggt

cctg

aagt

tggg

ctta

tttcc

ctgg

c

975

2972

483

—N

Ogt

gatg

acta

tggg

ccag

gaca

aca

976

2518

314

ITG

A4

YYEE

SSgc

agttg

gtgc

ttttc

ggtc

tgat

tctg

ctg

977

3680

796

___

NO

tgtc

tgct

tcaa

cctc

acac

ttctc

tcag

978

2329

274

—NN

OO

ctgt

ggga

agga

ctct

tcta

ggttt

tgga

ctct

ctaa

ttcttc

tgct

gaac

ccag

tgac

tgtg

taaa

catc

caga

ggcc

cacc

ccac

ccaa

agaa

tgtc

agac

t

979

3379

673

CPT

lAY

ES

ttcag

gcag

caag

agcc

ggca

acgc

catc

catg

ccat

cctg

cttta

cagg

cgca

aact

ggac

cggg

a

980

3549

257

___

NO

tgag

tcct

ccat

tcca

aact

ctcc

t

981

2360

474

FLA

Dl

YE

Sga

catc

tagg

gcct

ctga

acttt

ctcc

gggg

cgca

gcgt

gacg

gctg

gcat

catc

attg

ttgga

ga

982

2584

988

SCN

3AY

ES

aaaa

taag

atgc

ggga

gtgt

ttcca

aa

983

3630

231

LC

TL

YE

Stc

acat

gcaa

atgg

ttacg

gaga

tcgt

ggta

ccca

ctgt

ctgc

tccc

tctg

tgtc

ctca

tcac

tgct

gttc

tact

aatg

ctcc

tcct

gagg

984

3801

606

___

NO

ctgg

tgcc

aggg

ctcc

tctc

actg

ccct

acac

ttgca

ggga

ggtg

gact

tccc

tccc

985

2476

381

NO

agca

tcac

atat

tcag

ggga

ccttg

aaaa

gtttg

gtgt

gcct

gagc

atag

tgta

gctg

gaag

gtag

tggt

ggga

gatg

agcc

tgga

gagg

aaat

cagg

ggct

agaa

gata

aaca

ggaa

tata

tcac

agag

ttact

tacc

ttaaa

agta

atgt

tgag

ccac

tgaa

aggt

tttca

gcag

ctct

catc

aggt

ttgca

ttata

gaaa

gatg

gtct

tcag

gtgt

agttg

aatg

gttg

gagg

ggaa

gttg

gaac

aaga

ccaa

acta

ccat

ggaa

gaga

ctttc

atct

gtttt

gtct

cagc

agat

agag

ctgt

atat

gtct

tctc

cctg

tcct

actg

ttttg

gggg

actg

agat

tttgg

tact

catc

agca

ctct

tgct

ctca

tatta

tgga

OO

986

2522

188

LO

C26

0N

Ogg

tgct

gacc

caat

tcgc

tgcc

aaaa

gagt

gtca

atca

gaat

atac

aaat

cccg

tatg

gttg

tgtc

atcc

tctc

ttaat

cattt

ttact

aattc

taat

aatc

agct

ct

10ag

cttg

cttc

ataa

ttttc

atgg

ctttg

cttg

atct

gttg

atgc

tttct

ctca

tcaa

gact

ttgca

gc

987

2673

516

UQ

CR

CY

ES

atgc

cagt

gtgg

tacg

tgag

atct

gctc

caag

taca

tcta

tgac

1

988

3659

195

NO

gaag

aagc

agtg

catc

tggg

tggc

a

989

2652

475

NO

tctg

tccc

tctg

ctag

ttagt

tctg

taca

gtta

tccc

caca

gtcc

tcttc

ctaa

agta

gaca

ttact

ttcttg

ttcag

gtct

agag

ttggt

tgcc

ttcgc

atgt

agtta

aag

ttctg

tagc

atgg

tgta

taat

atcc

ataa

cact

caac

cctg

ctta

cctc

tcaa

gagg

cacc

tttac

ctgt

cacc

ccac

agtc

tatg

tgtta

aattt

ctgt

tccc

taga

tacc

ttggg

cctc

tttct

aaat

acac

acttt

catg

tcca

ttattt

cccc

ctgt

ctgg

aata

ctct

agag

ccttt

cattg

acaa

ttcac

ttgttc

tttttg

gtgc

ccct

cct

caat

gtga

ccct

tttag

aacc

ttcat

caca

gaaa

tagt

tgttc

tgttt

tttca

gcat

ctgt

gattc

tttcc

ctcc

ctgt

cata

gaat

aaaa

tgtg

tattt

atag

tcat

cac

caag

aact

cata

ttgcc

tcat

gggg

attg

tatc

tcag

catc

990

3198

107

—N

Oat

gaag

cagc

acag

gtac

gagg

tgca

ag

991

2994

022

—N

Ogt

agat

tcga

tggg

cccg

aggc

tcag

992

3548

367

—N

Otc

ctgt

tttct

gcat

tagc

tgttt

gcat

gtat

ttagt

aggt

taga

ggtg

ggaa

ctag

agat

caga

gaat

tgttt

atgg

cagc

agag

ttagc

agta

acttg

agag

ggca

tagc

taag

tcaa

agac

ctac

t

993

2440

185

CO

PAY

ES

ccaa

aaag

gtac

aggt

gccc

aact

gtga

tgag

atct

tcta

tgct

ggca

cagg

caat

ctcc

tgct

tcga

gatg

cgga

ctct

atca

cact

ctttg

acgt

acag

caga

agc

994

3480

073

—N

Oat

gggg

ctta

tcct

tact

cgca

gtca

ccta

aaag

995

3513

910

KPN

A3

YE

Sgg

tcca

attg

agtg

ctgt

ccag

gca

996

3978

139

___

NO

gaag

gcct

cggc

aaag

gact

gtgc

t99

725

4009

1__

_N

Oca

gctc

cagg

gtga

aatg

gtgc

tag

998

2896

688

—N

Otc

ccga

gggc

tgat

cact

ggaa

acag

ggca

acct

ctgg

tgac

ctgg

tttttc

atca

ccag

ccag

ggca

gaag

aagt

caaa

gtgt

gctc

aagg

gcttt

gcac

gctg

ctcc

ctag

aact

gg

999

3022

504

NO

actg

tcttg

gtgt

tggt

cagg

atta

atat

aagg

gagt

g10

0031

0404

4__

_N

Oat

ggcc

tgaa

agct

ttagg

tggt

gcaa

caca

gggt

gaa

1001

3939

535

SLC

2A1

NO

caat

caat

ggtg

agcg

tggt

attc

cagg

ctaa

aggt

aatta

actg

acag

aaaa

tcag

taac

aaca

taat

taca

ggct

ggttg

tggc

agct

catg

actg

taat

c1

ccag

cact

ttggg

aggc

caag

gtgg

gagg

atca

attg

aggc

caga

gtttg

aaac

cagc

ctag

gtaa

cata

gtga

gacc

ccct

atct

ctac

aaaa

aattt

taa

acat

tagc

tggg

catg

gtgg

tatg

tgct

aaca

gctc

tagc

tact

cagg

aggc

tgag

gcag

cagg

atca

cttg

agtc

caag

agttc

aagg

tagc

agta

agct

acaa

tcac

acca

ctgc

atgc

caga

ctgg

gtga

caga

ggga

gact

tcat

ctct

ttaaa

acat

aata

ataa

taat

taca

gact

cagg

aaat

gcag

tgaa

agaa

aaa

taca

ggttg

gcca

ggtg

aggt

ggct

gatg

cctg

taat

ccca

gcac

tttgg

gagg

ccaa

gatg

ggaa

gattg

ctttg

agac

caga

agttt

gaga

ccag

cctg

ggcc

acat

agta

agat

cctg

tttct

acca

aaaa

aaaa

aaaa

aaaa

aaat

tagc

tggg

tgtg

gtgg

taca

tgcc

tgtg

gtcc

cagc

tact

cagg

aggc

tga

aatg

ggag

gatc

acttg

agcc

tggg

aggt

cgag

gctg

cagt

gagt

ccta

attg

agcc

actg

cact

ccag

cctg

gaca

acag

aaag

agac

catg

tttca

aaaa

aaat

aaat

acag

gttg

tagt

gggt

atgg

gtat

gcat

acca

ggag

gccc

gacc

tcgt

ctga

gagg

ggag

tggt

caga

aaag

aattt

tctg

agga

attg

atg

ttttta

atca

acttt

attg

aggt

ataa

tttat

acat

aacc

aact

gcat

ccat

tttaa

gtat

atat

ttggc

gagt

tttga

gttc

taag

tata

gtttt

ggtg

agtg

tata

cact

tgg

gaaa

cacc

accg

tgat

caag

atgg

aacc

tttac

ccta

cccc

aagg

cacc

caca

tgcc

cattt

gcta

tcag

taac

ccac

ccca

gtcc

caga

cctg

gg

1002

2420

794

NO

taga

tctc

caca

tgat

aacc

tgttg

aact

ttttg

agta

tctg

ttgat

caag

aaaa

taaa

gtca

aaag

ctac

aatta

atta

gtaa

tgtg

ctca

aaat

aaat

ttgta

tttt

ataa

atca

taac

atct

tttcc

atgt

tact

ctgt

ctat

atgg

agttc

ttaat

acca

caca

tttgc

ttagg

gaga

tgga

atta

gcaa

ctag

tctg

tgct

accc

tgta

tttttt

tttta

acca

tgta

gttg

gattt

tttaa

aata

caat

aaaa

gagt

tcac

ttttc

cagg

tttga

caac

atttt

tatg

aattg

gaaa

ttttc

tgtg

gcta

caga

tact

atta

acat

tttgg

aaag

gtgt

aaag

aaca

ttgttt

taat

gtaa

ggct

cttc

tcta

acct

ccct

cccc

tctc

caaa

ttctc

cata

atat

gaag

tagg

aaga

tatg

tattt

ttctg

ttgcc

atta

aaat

gttc

tggc

catc

gtgg

gagt

gggg

atgg

ggag

ggcg

ggga

tggg

aatta

gaac

ttact

agaa

taaa

attc

caaa

taga

ggttt

gggg

aaac

ctac

ttgtg

agtg

ctttt

taac

ctca

aaat

aagg

atttg

gggt

gggt

ggag

aagg

tgat

gggg

caga

agaa

gttg

tttttg

gagg

agag

aaag

caga

ttgaa

agg

aaaa

ggac

agct

gata

gcca

ctta

aata

atgt

catc

gtta

gagt

gata

ccta

tttttt

gtaa

aaag

aaaa

caat

atgc

tcca

ttctta

caaa

gcat

tgat

tgta

tttt

aata

tata

caat

gtaa

atac

tatc

atgc

agtg

gtgt

ccaa

ggga

gaga

atac

agtc

atga

gttc

ttagt

ttctg

ttattg

gttg

ggcc

aata

aagc

ccct

tcat

catc

cttc

ttttc

tgct

tatc

acta

gaga

caga

aact

aaaa

acca

tggc

ttcag

gctg

ctaa

aagc

ctaa

aaca

aaac

agaa

caac

aaca

acaa

ataa

ggca

ggt

tgga

caag

cttg

ctga

gtat

ttggg

agcc

tttttc

1003

2444781

—NO

taat

gggg

ccaa

aggg

gcaa

caca

aagc

attg

aaaa

catc

actg

gctc

acaa

aaac

agtc

acct

tgtta

ccttc

tcag

ttgca

tttgt

ttattt

caca

aggc

ttcat

tcac

acat

aaaa

acaa

gata

ctaa

tcca

attc

aagt

tcat

aacg

atta

taaa

agta

aaca

tttgt

tggg

acaa

tgta

caat

aaat

tgca

ctttt

taga

caag

cat

taca

tttac

attta

taga

gtgt

acta

taca

taat

acat

ggaa

ttacg

gaaa

cgtc

taat

tggt

cattg

1004

2537266

—NO

tgat

acac

ttctg

aacc

acag

ccag

ggtc

cagg

cctg

aaca

gatg

tcag

catc

ttcag

ggag

ctttt

gcca

ggac

gccg

ccca

gcca

catg

gcca

ccac

gttc

attc

aaac

acgg

ggct

tcct

gtca

aact

acac

taga

1005

3061935

—NO

aaga

ggtc

accc

ttgcc

gtttg

atgg

aatg

ccta

ttattt

gata

gctg

ctga

tacc

acga

taac

acag

agat

tccc

tttca

atta

aaag

tgcc

tgga

cacc

acag

ccag

acaa

cttc

tgtc

ccac

caca

tgta

tact

gaat

ttcag

tcttc

ttaca

tctc

atttc

aaat

atat

tttga

aata

tattt

ccag

tttat

ataa

atag

tata

acac

ctaa

caat

tccc

attta

tttgc

aaat

atta

ttgtg

agga

tcga

ctgg

gaca

taaa

tg

1006

3893061

—NO

ttcct

gtcc

agct

aaag

atgc

tgcc

tggc

cgtg

gcct

ccac

gctc

tgta

aaca

tgac

ccac

accc

ccca

gggc

actc

cacg

gaag

ccttg

gaga

taag

ggac

acat

cact

tcta

tgct

cacc

tgaa

gtga

cccc

attg

ttaaa

ggac

acag

ctca

actc

aatc

aggg

cacc

agca

gcga

ctcc

aagt

cagg

gtgc

aaac

tct

ggag

gctg

ctgt

gtga

gggg

ggca

ctag

agat

ggtg

gtaa

acag

aaag

gggg

gcttc

cttc

acca

gcca

ggtg

accc

cagg

caag

tcac

aagg

aacc

gctc

tgat

cca

1007

3996137

—NO

ccat

ggaa

tcct

gttg

gagc

tggt

ctac

agaa

1008

2424640

DPYD

YES

tggg

agaa

ttgttg

ctat

gcag

tttgt

tcgg

acag

agca

agat

gaaa

ctgg

aaaa

tgga

atga

agat

gaag

atca

gatg

gtcc

atct

gaaa

gccg

atgt

ggt

catc

agtg

ccttt

ggttc

agttc

tgag

tgat

ccta

aag

1009

2823618

—NO

ttcct

gcta

ctgg

ttggt

taat

gagg

cact

gagc

tagg

aacc

ctgt

aagt

gttc

aagt

gtta

aaat

tgtg

ttgttg

tacc

tttaa

atat

aagg

agaa

gaaa

ttggg

agag

atca

gatta

aaat

atta

aata

ctta

tatg

gttta

gaaa

agtg

acag

cata

aggg

agat

caac

cagg

tttaa

gggt

aaat

actta

ggtg

acca

gaag

atct

acag

taaa

cttg

agga

cata

tccc

acca

agac

ccac

aact

cagc

tcca

gctg

attg

tttcc

acaa

tagg

actg

aatg

cctg

c

1010

2491474

—NO

atct

ggcg

tgga

gatc

gttc

aaag

gtgg

gaaa

ctac

ggga

ggaa

ggta

ctca

ggtg

ttgag

tgca

gcca

tggg

gcca

cttg

aatta

gcat

ccag

gcag

cccg

cgcc

cctc

ccca

gaga

caat

cagc

ggtg

tttca

1011

3780190

—NO

ccca

tgat

gtct

gtcg

tgca

gatg

aatg

tgtc

cacg

cgtg

ctgg

gcta

gtac

agaa

gatc

g1012

3443271

—NO

ccac

agta

tggt

cattc

agcg

aaag

aagt

acca

agta

tttct

ttctg

ttaat

gagt

caga

ggta

ttaat

atat

gtat

gtga

gtcc

ccca

tttac

cctg

cgca

agat

aagt

tcttt

taaa

tgca

atta

gaat

atcc

taag

ataa

atta

caaa

ctcc

tctta

tgta

tcct

tttct

ctga

ggtg

aaat

gaga

cact

gcac

agat

gaga

ggta

ctat

t

1013

3249840

—NO

gcac

tgaa

cgct

aatc

ccttt

ttcta

tttcc

gcttc

tcac

aggc

acag

gaac

acag

gcac

aaat

gcac

acca

caca

1014

3365366

HPS5

NO

gggg

ctac

ttttg

tcag

tgtc

tgta

ccct

tggc

atcg

gcat

ctgt

gact

cttta

tcca

tgac

ctca

gtgt

ttctta

acca

aagt

tgta

ctca

gcat

ttctta

acca

aagt

tgaa

ttttg

aaaa

gagt

cagt

ccttg

tttgc

tgga

atta

gaat

gtta

atgt

ccta

gtat

tattc

cgaa

ctac

agta

ttaac

tgct

tgttg

ctag

tgga

ttaga

caga

ttcttt

tctta

ctgt

ggct

tcca

tgttg

ggag

caga

agct

tttca

tcct

ggtc

acat

gaag

acag

atgg

tatta

ttgac

tgga

gttg

aatta

ttttta

tatc

ttgtc

tgg

caca

atat

ggaa

atta

ctga

aata

agac

ggtg

tata

atgg

aatta

acac

ccaa

aata

agta

gaac

actg

aaga

tttga

atttg

atat

ttaag

taaa

atgg

gact

ggg

tgca

gtgg

ctca

ggcc

tgta

atcc

caac

ccttt

ggaa

ggta

aaga

cggg

agga

tcac

ttgag

gcca

ggag

ttcaa

gacc

agcc

tggg

caac

atag

tgag

aatg

catc

tcta

caaa

aaat

aaaa

aaaa

ttagc

tagg

cata

gtac

ctga

ggcc

agga

ggtc

cagg

ccgc

aatg

agat

gtgt

tt

1015

2883

453

AD

AM

lN

Oct

ggct

gtat

ggct

gcat

gtga

caag

ccac

gtcc

cctc

ccac

ctct

cccc

aaac

ccct

gcat

ccct

gtat

tcac

acgg

gtca

ctct

gact

ca9

1016

2924473

—N

Oag

cagg

gact

cagc

gtga

ggct

tgaa

gcaa

acag

tgga

atct

ttaga

agcc

tgct

ttgtg

tgc

1017

3378661

—N

Occ

ctgg

gtgt

aacg

aggc

cattt

tgca

acta

catc

cagc

cagg

ctga

aaac

actta

cttta

ttccg

agtc

catc

agaa

ttcttg

aaaa

tcag

agga

tctc

tcaa

gcca

cccc

gctg

aata

tact

ctac

atta

aaat

ctgt

cacc

atag

gaaa

atat

taga

aaga

taag

tggt

ataa

ttaaa

aacg

ataa

aagg

acca

taaa

aagg

atcc

taag

taat

acag

tata

aatg

gtgt

ttgtta

ttctg

tgta

tata

gtta

tgct

gtta

gtca

ataa

aata

tatg

ctta

gtaa

gaag

catc

tctta

gaaa

atat

ggag

agc

acat

tgag

aagc

aacg

cttg

aggg

gtttt

cca

1018

3754749

DDX52

YES

aggc

tggg

tgtc

ctgt

acca

gaat

acat

aaaa

g1019

3150460

—NO

gctg

ccca

cggg

acttt

gcag

gagg

1020

2664515

—NO

ttctc

tttag

actta

ccag

ttagg

ctct

aattt

agga

aaaa

taaa

acaa

aaac

ttaca

tggg

tttgg

agta

aaat

tagc

tgga

gtaa

aatc

caag

gcta

gattt

cta

ttgaa

1021

3123616

—NO

agga

gggc

ccaa

tatc

cctg

ggtc

g1022

3432252

—NO

agtg

gtca

aacc

caga

tgag

ggtc

ccgc

ttctg

gttta

tata

caat

aa1023

2593632

—NO

ggag

cggg

aagg

agat

tgac

tgtta

gtttc

tta1024

3054956

—NO

tgtg

ccag

ccac

agta

cgat

gtac

ctcc

tcca

atct

atgt

gtcc

aaat

cagc

gcat

ccttt

aagg

ccct

actc

agat

ggca

cc1025

3096135

—NO

ggga

ccca

gaag

caac

cgtta

tgag

caac

aaaa

ggaa

gaca

ctgg

tttgg

atgg

acgg

gaag

cggt

tggg

tggg

ctgg

actg

acgg

aggc

ccct

ttag

a1026

3541539

—NO

tgtg

ggct

ggcc

atct

atat

ccat

ccat

ctat

ctat

tattc

cacc

catc

cctc

catc

catc

catc

cattt

attta

atta

agtta

ttttta

acgg

ttggc

tctg

gagt

tgac

attc

attta

tttta

aaag

aaca

gtga

atca

tagc

tcttt

tcct

caag

atgc

ttgct

tttat

ttgca

tggt

ggca

tattg

atta

agta

ctca

gaac

acta

tttga

cata

tgg

taag

ccct

caat

aaaa

gtttg

ttatta

ttatg

actg

tact

tctc

ccct

ctaa

tgta

taga

ggta

aaca

ttttg

gttc

ctat

tgtg

acac

gtgg

gtta

taat

gagt

tagg

gcct

actta

agaa

gaaa

gtgg

aaag

aaag

cggg

taaa

attg

ttgct

caga

tact

agca

tgtg

ggtg

ga

1027

3762591

—YES

gggg

cggt

ggtc

atta

attc

tgct

atct

tagt

atct

ctct

ctgt

tttgc

tgct

tgtg

cact

tttct

atttc

tacc

ggtg

tgcc

agct

ct1028

3305557

-_-

NO

acct

gcca

tcct

cata

gtca

ccgg

gag

1029

2394713

TNFRS

NO

tggc

aaaa

gagc

aatc

tgga

tccg

cctta

gcca

gata

cata

aggg

tattt

gcct

tcac

tttca

gcca

gcat

tccc

ccca

gcga

tcct

agcc

agat

atta

cF25

1030

2406204

—NO

ctga

tatg

tatc

tgttg

ggca

agta

gttc

catg

agga

gtttg

tttttg

ttcag

aatg

atct

ttagg

aaaa

atgg

aaat

acca

cggt

gaag

ggaa

agaa

gtca

gaa

tatg

taca

caaa

gcct

a

1031

2722321

TBClD

YES

tgttt

ttccc

ggga

taca

tctg

tgttg

agtc

acttt

gcat

tcaa

cagt

gcct

cgcc

acca

aaat

cata

cata

a19

1032

3532235

NO

atag

tgtta

tatc

cgtg

ctgc

cata

tcac

taaa

atag

gcttg

ccaa

ggca

ggtg

aggt

gtat

gaat

gctc

aagc

ctca

caga

actg

caat

caag

tgcc

aact

ataa

ataa

tact

gaaa

aaag

ttgac

catc

tgac

cagt

ggat

aata

ctttc

aagg

cattc

aatta

gctta

tcct

ttgca

gtat

tcta

agct

attc

acat

tgac

gatc

acat

acat

tgta

gtgc

ttgct

gcaa

ggga

ggca

tata

acca

gttg

ttttg

gcta

aaat

atga

cagg

aagg

cattc

cttg

ggttc

tata

taaa

agta

acag

tattc

aaca

gtct

aatg

gcaa

tcac

tgat

aggc

tgct

taaa

1033

3053937

NO

tgca

cgct

ggaa

tcat

ggct

cattg

cagc

ctcc

aact

ccta

ggct

caag

ggat

ccttc

cacc

tcag

cctc

ccga

gtag

ctgg

gagt

acag

gtgt

tcgt

cccc

acca

tgtc

tggc

taat

ttaaa

aaaa

tgtc

tttgc

agga

tggg

atct

tgct

atgt

ttccc

aggc

tggt

ctca

aact

cctg

ggct

caag

tgat

tttcc

catc

ttggc

ctcc

caaa

atac

tggg

atta

tacg

tata

agcc

acca

cgtc

tggc

ctga

gtca

tctc

ttttg

accc

agaa

caaa

acca

gtcc

agga

gtgg

ctgt

actc

ccca

gga

gtgt

acac

tggg

gagg

ccca

cagc

tccg

gggt

gcag

tggg

gctc

ttgca

attta

atga

ctga

ttcat

cttc

aaaa

aagc

acaa

tctc

agcc

aggc

g

1034

3304915

NO

tggg

agac

tgac

ctaa

ctga

gcat

caac

tatg

ccaa

gcac

tgcg

caag

gtgt

cgag

gcta

tagg

aacg

tgcc

tttct

accc

taga

gaag

tttgc

agtc

tgct

gtgg

gtga

tgag

ctat

atag

aaga

atgt

acta

ttaga

tgga

ggga

agtg

aggg

agca

acat

ggtta

cctg

agga

agag

cagt

ccag

gcca

aggg

caca

gca

agtg

caaa

ggcc

ctgg

ggtg

acgg

tgtg

tgct

ggct

gctc

atga

tgca

gtag

ggag

gcct

gtgg

ctgg

gatg

aaga

atag

tgga

gggt

aaag

tgga

aag

aggt

gaga

gcag

agat

gtag

ctgg

cagt

gggg

aggg

aata

gggt

gaag

cagc

acca

tgta

gggc

cttg

cagg

acat

tcta

agga

ttttg

acttt

catc

gagt

gaga

tgaa

gattc

actg

aggg

gttc

taag

taga

ggca

ggga

catg

atct

ggct

tcaa

tcat

agaa

tgat

gggg

attg

acta

ggca

ggat

gggt

tatg

atg

tgca

aggt

cgca

gggg

gctg

ctag

ccag

gtga

gata

ggat

gtgg

gctc

tggc

agca

gtgg

aggg

ggca

aggc

actg

cggg

tgttg

gaca

gact

ctg

atga

ttgga

tgtg

ggcc

tcaa

ggga

gagt

ttgtg

tggg

agct

ggga

aaca

actg

catc

aggt

tgcc

tggg

gtcc

cact

ctta

ggcc

gaca

acttg

4-

1035

3545436

NO

gcgg

tcac

tcag

ctat

ccaa

tggg

atga

caca

cagc

aaat

cagc

tcttc

actg

cctc

aaca

gaca

gtca

ctaa

aata

atttc

tttaa

aggt

atat

aaat

gttg

gcca

gtgt

aatc

ctct

acaa

aaca

cattt

gcaa

atat

aaaa

taat

ggag

gtat

gatg

ctgc

tcag

agaa

tggg

aatg

ctct

ggca

gtcc

ccaa

catc

ctat

ccca

cttg

gggc

tttgc

tccg

aggg

gaag

agca

ggtg

cagg

atat

attg

ccct

ttgat

gtga

tgta

gatg

ctac

tagg

gacc

cact

ggga

agag

tccc

gttc

cttg

agt

tatg

ctac

tgta

ggga

taga

ccct

tggt

gtga

ggaa

tcta

acaa

tgag

tcaa

agga

aaca

tcac

aaag

aagg

tgac

acct

caga

ggag

acaa

agga

ctct

gaaa

tcct

ggaa

tcac

ggga

tatc

tctg

attg

gtta

ggga

attc

ctct

gcac

tcaa

tctc

cagc

aaat

gggc

agat

tccc

tcac

aact

taga

atttt

tcat

ggg

gagt

gctg

gact

gtac

ccca

aaca

tgga

gtaa

ggtg

gcat

catc

catc

tctg

aagg

gcca

tact

cctc

gcaa

agc

1036

2632506

NSUN3

YE

Stg

aata

tgat

agtc

tgag

attg

aggt

ggct

aagg

caga

cgttg

gaat

ctttc

atcc

caca

gcct

ttgat

aaat

gtaa

ttaaa

gtgt

ctga

attg

gatg

gcag

a1037

3333132

—N

Occ

tgag

ttcct

gggc

actc

tttcc

tgag

cttg

cttg

gggc

tgat

ttgaa

ttcag

1038

3459329

—N

Oct

ctgg

atttt

gcca

ctca

caca

gttg

1039

3597530

APHlB

YE

Sgc

cagt

gaag

gtttg

aaga

gtat

aaac

ccag

gtga

gaca

gcac

cctc

tatg

cgac

tgct

ggcc

tatg

1040

2757682

—N

Oaa

cagt

gcaa

gaaa

ggac

gcat

cact

ctct

tctg

gtgc

cgat

gtgc

tctc

ttgtta

a1041

2811303

—N

Otc

acgt

ggct

ttgtg

tacc

aggc

gtcc

aggg

agca

atta

ggag

ggca

atct

gtta

agtc

ttttg

cctc

aggg

caga

acca

ttagg

tgtg

ctgt

gtat

gtgc

ctc

aagg

ggtg

taaa

taac

taag

ctat

tcat

gtac

tcat

cagt

ttcct

ttcaa

ggca

tctg

tgaa

acct

ttaat

ctgt

ggaa

gaat

caga

gaaa

gttg

acct

attg

tatt

atta

tcct

ccct

cacc

tgaa

tattt

tga

1042

3611

032

TT

C23

NO

gagt

ccttt

tgtc

ctgc

ggtc

cata

taag

aggg

tctg

gatc

tgga

gaca

ctgt

agaa

cacc

aagc

agct

atca

tgag

gcta

tgga

agtg

tcgc

tgag

agca

gga

aact

aagg

tctc

ccttg

aatg

agag

aaag

atga

cctc

attc

ttagg

ccct

gctg

tgat

ggaa

ttagc

atgc

tcct

ggga

tgtc

tcct

agtg

actg

acct

ttgg

tttgg

atgt

tctg

aggg

atct

aggc

aaaa

gtga

acag

tttta

gcac

tattt

caca

aaac

tctc

tgtg

acta

tctg

tatg

caaa

aaat

agat

ttaaa

agta

gtat

tttt

aaaa

ataa

aggc

aaga

acct

tggt

actg

acca

gagg

atgg

gctc

cagt

ttcta

ttttta

aatg

tggc

ccttg

ttata

gcct

ggaa

aaga

tttaa

aaaa

atag

tttt

gtttt

ttttg

taaa

caca

tact

ctac

tttta

ttaat

atat

aggc

tgtc

tata

ctct

tgac

taca

cagc

aatg

tctta

gtta

ttagg

aacc

aaat

attc

agct

tatg

gact

acc

cagg

gctg

gcttt

ggct

tgat

ttctc

ccttc

tgct

tact

ttaag

tcttg

ccat

ttgat

tgct

tgta

gtag

gcta

gggc

aaat

caag

gaga

ggag

aaag

atta

aagt

tgtg

ccca

aaat

ggcc

aaaa

taat

tttga

gaaa

gaat

gagg

tgga

gagg

tgga

ggaa

cttg

cttta

ctga

atgc

caaa

gacc

ctttt

atttt

tttaa

ataa

agt

aatta

agac

agca

tgttt

gtca

cccg

gggt

agac

aaaa

agac

cagt

ggaa

cagg

gcag

agag

ccca

agcc

ttgac

agat

gaca

gaaa

tggc

cttg

cggg

attg

gtga

ggaa

gagg

tggg

ctag

tcaa

taaa

tggg

tact

ggga

ccgc

tggt

tttcc

aaat

ggaa

gaaa

atgg

atca

ctac

ccca

aatc

aaac

acaa

atat

taa

gctc

aaga

aaga

tttga

agga

ctaa

gtgt

gaaa

tgca

aaac

ttgga

gcttt

taga

tgaa

aata

ctgg

aaaa

tata

ta

1043

3977071

—NO

gtgg

ctgg

acca

tgcg

gaac

tgga

t1044

3363301

DKK3

YES

tgat

ggag

gaca

cgca

gcac

aaat

tgcg

cagc

gcgg

tgga

aga

1045

3644748

___

NO

tggg

ccac

gtgg

tgct

ctct

gaag

ttaga

a1046

3799937

___

NO

catg

cagt

cccc

aagg

ctat

cggt

cctc

ctca

g&

1047

3336773

FBXLIl

YES

gagg

agct

tgcc

aaca

gcga

tccc

aagt

tagc

cctc

actg

gagt

tcct

atag

taca

gtgg

ccaa

1048

2822962

___

NO

tgtg

agaa

caga

ctcg

gcag

tgac

atcc

actc

caaa

tgga

1049

3627325

___

NO

ccag

acct

gagc

cacg

tagc

tatc

aaac

ac1050

3780263

___

NO

catc

tgaa

atta

atgg

gact

aatg

taag

gattg

atat

tttca

tattt

gctc

aattg

catc

ctgg

gtta

agca

cattc

aaca

g1051

2656010

VPS8

YES

atgg

cgct

atct

ctgc

cctc

agta

tc1052

3028587

___

NO

tcac

ccag

gattc

tcct

gtac

ctgc

tccc

aatc

tgtg

ttcct

aaaa

gtga

ttctc

actc

tgct

tctc

atct

ccta

ctta

catg

a1053

2419066

ZZZ3

YES

gttg

ccttt

gagt

gatg

gtcc

agaa

g1054

3081481

___

NO

atgg

ccac

ctgt

gttg

acgt

ggag

a1055

3935290

___

NO

atga

tgaa

agcg

tgga

ggta

ccag

ct1056

3051677

ECOP

NO

ttgat

gtgt

gaac

gctg

acct

gtcc

tgtg

tgct

aaga

gcta

tgca

gctta

gctg

aggc

gcct

agat

tact

agat

gtgc

tgta

tcac

gggg

aatg

aggt

gggg

gtg

ctta

tttttt

aatg

aact

aatc

agag

cctc

ttgag

aaat

tgtta

ctca

ttgaa

ctgg

agca

tcaa

gaca

tctc

atgg

aagt

ggat

acgg

agtg

atttg

gtgt

cca

tgct

tttca

ctct

gagg

acat

ttaat

cgga

gaac

ctcc

tggg

gaat

tttgt

ggga

gaca

cttg

ggaa

caaa

acag

acac

cctg

ggaa

tgca

gttg

caag

cac

agat

gctg

ccac

cagt

gtct

ctga

ccac

cctg

gtgt

gact

gctg

actg

ccag

cgtg

gtac

ctcc

catg

ctgc

aggc

ctcc

atct

aaat

gaga

caac

aaag

caca

atgt

tcac

tgttt

acaa

ccaa

gaca

actg

cgtg

ggtc

caaa

cact

cctc

ttcct

ccag

gtca

tttgt

tttgc

atttt

taat

gtct

ttattt

tttgt

aatg

aaaa

agca

cact

aagc

tgcc

cctg

gaat

cggg

tgca

gctg

aata

ggca

ccca

aaag

tccg

tgac

taaa

tttcg

tttgt

ctttt

tgat

agca

aatta

tgtta

agag

acag

tgat

ggct

aggg

ctca

acaa

ttttg

tattc

ccat

gtttg

tgtg

agac

agag

tttgt

tttcc

cttg

aact

tggt

taga

attg

tgct

actg

tgaa

cgct

gatc

ctg

1057

2699603

NO

aaag

aagg

atct

gtca

gcca

agtc

ttttc

t1058

2836754

NO

agtg

tggc

cgttt

gcat

tact

gctg

gaat

tttga

agac

tact

acat

attc

cgtc

agtg

tcag

gattt

tgttc

ttcag

tgtg

gtac

tttttt

tttttt

tttttt

aaga

tgga

gtct

cact

ctgt

cgcc

tggg

ttgga

gtgc

agtg

gtgt

gatc

ttggc

tcac

tgca

acct

ccag

ctcc

cggg

ttcaa

gcga

ttctc

ctgc

ctca

gcct

cctg

agta

gctg

ggat

taca

ggca

tgcg

ccac

caca

cctg

gctta

tttttg

tattt

ttagt

agag

acgg

ggttt

cact

atgt

tggt

cagg

ctgt

tcttg

aact

cctg

acct

cgtg

atcc

gccc

acct

cagc

ctcc

caaa

gtgt

tggg

atta

cagg

cgtg

agcc

accg

cacc

cggt

agtg

tggt

acac

tctta

aaat

cata

gttc

ctgc

tgtc

tg

1059

3504560

—N

Ogc

atgg

ccat

ggat

cggg

caag

ttggt

tttac

t1060

3924596

PCNT

YE

Sag

acct

gaag

gcac

aatc

acaa

gaag

agat

cagg

cgct

tgtg

gtcc

cagc

ttgat

tctg

ccag

gacc

agta

gaca

ggaa

tt1061

2408919

—N

Ota

ggtg

acgg

attg

ttagg

tgca

gtaa

acc

1062

3219942

PTPN3

NO

ggac

cagg

cttc

tacc

atta

attc

acat

gcttt

aaaa

aaat

taaa

aatta

aaaa

aatg

aaaa

ataa

aaaa

actta

aaag

atttt

acct

atat

tcct

ggaa

cata

gtt

atct

tacc

ccag

ctttg

tagt

tcct

gttta

agga

aattc

cctc

tgaa

ggaa

atttt

agct

ctca

agag

tcaa

agaa

gatg

tata

gagg

tggt

atct

gtta

gtttt

tgtt

tgttt

gtta

agga

tcta

ggca

gaga

ggtc

atta

cattt

ttctg

aagt

tgag

gtca

cagg

tggg

gtac

ccac

aaga

gagg

tcat

taca

tttct

gaag

ttagg

catc

ccag

gcat

ctct

tcta

aaga

acta

tcct

gtat

tcta

attg

ttaaa

taaa

tatc

ttcttc

attg

tgag

cctc

caca

actg

ctgt

ttctg

ataa

attta

gatc

attc

tttgc

aga

atttt

atat

actg

gcaa

tctc

aaaa

ctag

gctc

cttc

aaga

ttcct

agga

agtc

tccc

aagc

tcgg

gttg

ggttc

cact

attc

tag

1063

3240958

DNMlP

NO

gtca

acaa

gacc

ttgct

ggac

ctcg

tg17

1064

2830809

—NO

gtgc

agat

tgtta

atcc

ctag

tgtg

cagg

gata

ggga

ggga

gagg

aaat

gtcc

acac

agac

gagg

agaa

ggcc

tgta

aatg

caaa

tttca

cact

gttg

atg

gtttg

tcct

gttg

gttg

acca

gcat

tccc

aaga

taac

cagg

tgag

1065

3020549

NO

cctc

atgc

atgc

ttcga

gatc

attg

tttgc

ttcat

ttccc

taaa

atct

acag

ttcct

ttgaa

agta

gact

ctgg

cgtta

tcac

ctttc

cccg

gtct

ttttg

cagt

ttcct

gttg

acct

ctga

gcca

ttctc

cctc

actc

ttgttt

cact

ctgt

ttgca

acac

tacc

tcttc

ctgt

atcc

tggc

ctct

cattt

ctca

caga

tcat

catg

ctgt

tcttg

aaac

atttt

attta

cttg

atttt

agaa

aact

atac

tctta

gtttc

ccta

aaat

ctca

taat

ctct

ttgcg

ggat

tttcc

tcat

ctttg

tgac

ttcca

aaat

ttgaa

gtgt

cccc

tgg

ccag

tcct

gggt

ggct

acat

tcaa

tctc

1066

3282482

—NO

aaaa

gaag

tcgt

ttattg

gtgc

atgg

gaca

ctct

ggga

ggta

gtat

ccat

ttgga

tgtc

ctgc

tgcg

gttg

gaga

catg

gaac

aaaa

1067

3192070

—NO

cctg

tcgg

tgga

ctga

atgg

gcca

agtg

ttcag

aagt

ccttg

ggaa

gagg

atag

tgtc

ctga

atca

taat

gtgg

tattt

tc1068

2473609

—NO

aaag

tgtc

ctat

tctc

gggg

tggc

aggg

aggg

gggc

aggc

caca

aagg

acat

gagt

gtta

ggaa

aaga

agaa

agca

cagg

gaat

taag

gcag

gaag

gga

tagg

ctaa

ctac

tgttc

tgtg

caaa

tgca

attg

ggttt

atga

tcag

gact

gact

gccc

ttacg

tata

aagt

tgct

aacc

ccca

agac

ctga

aggg

aaaa

gtc

ttttg

aagc

tgcc

agttt

tttga

tcat

tcaa

caag

aaga

cctg

aaca

ctga

gaat

ccttt

ttctg

gattg

gttc

catc

aata

ctttg

tccc

tgaa

atca

ggaa

atac

cttg

ccat

tatg

ggac

agcc

cttta

aagt

tcttt

tgat

gttg

gaca

gtgc

ccct

ggcc

accc

agaa

cccc

atga

gttta

acac

cgaa

aaca

ttgaa

gtgg

tcta

cttg

cccc

cgaa

caca

gtct

ctaa

ttcag

catc

taga

tcag

ggga

tcat

gagg

acct

ttaag

gtta

ataa

caca

cggt

actc

taac

ctca

atag

aaca

tcat

gaa

aatc

tgga

ggaa

ttaca

ccgc

tgaa

gatg

1069

2814

779

NO

actc

tgct

gact

gtaa

tggc

tctc

acgc

agttc

ctaa

tggg

cact

gtgg

aacc

actc

agca

taga

cagg

cata

ggca

gg

1070

3558342

—NO

gccc

agtg

aagg

ggtg

acag

aact

agcc

1071

3611698

LRRKl

YES

atct

cctg

ccag

atca

cgga

gctc

gacc

tttct

gcca

actg

cctg

gcga

ccct

cccc

tcgg

ttatc

ccct

gggg

cctc

atca

atct

ccgg

aagc

tgaa

cctc

tcc

gaca

acca

cctg

gggg

agct

gcct

ggcg

tgca

gtca

tcgg

acga

aatc

atct

gttc

c

1072

3701429

NO

tgcc

gcttt

tccc

tcca

cttg

tgta

acag

cata

ctca

ggttt

atac

caac

tggg

agac

acgc

aggc

atct

cccc

tcac

aagc

agct

gtct

actc

aattc

tgta

gtt

atgt

ctgc

taag

taat

caga

atgc

acaa

tagg

ttttta

gcat

ctgt

atct

catc

ctca

gagt

agag

agta

cctg

tttta

cgag

agaa

aact

gaga

aaac

ggtc

tct

cagg

gcct

ctgg

ggca

gcct

tcaa

ttgga

cagc

agta

gaat

ttcgg

tcca

gtttt

caaa

tcttt

tctta

ttgttg

gattg

acta

tgcc

atcc

tgca

aaag

gaaa

atta

cttta

aatta

ttattt

caaa

aaaa

caac

acaa

cagg

ctgg

agtg

gaaa

cgga

atga

ctga

aaac

gagc

acat

tttgt

gaaa

tact

tttaa

ttaag

agttt

ttcca

tcta

gtgt

cagc

agta

agag

aaaa

agag

tatg

agta

gatta

aacg

aaat

gtgg

tgag

aata

ctaa

gcaa

gact

ctaa

aattc

tgca

ttcat

ttgac

catta

ctg

aattc

ctct

tagt

caat

ttaca

ttcca

ggga

gatg

cccc

ccttg

tatg

ttcct

aggc

tgtg

aaat

gctc

ca

1073

3933

333

C2C

D2

YE

Sttc

cgcc

ggcg

gcat

caac

agaa

agac

ccag

gcat

gagt

cagt

caca

caat

gacc

ttgtg

ttcct

ggag

cagc

caga

gggt

tccc

ggag

gaaa

ggca

tca

1074

3799

749

—N

Ottg

gattc

cact

aatc

accc

gatc

accc

c10

7524

8713

1A

NT

XR

YE

Sga

aagc

tgca

ctcc

aggt

cagc

atga

acga

tggc

ctct

ctttt

atct

ccag

ttctg

tcat

catc

acca

1

4-10

7631

8771

9—

NO

gggc

aaac

ttcag

cctc

atta

gata

gagg

ctgg

acttc

cgga

agag

ctgg

gaag

gggg

acca

tagt

ttctg

ggga

gggg

tgga

gaac

tcac

attta

ccta

gctg

ctgg

ccag

gcta

ttttc

atac

ccac

agac

cgat

ttaat

tctc

aact

actg

tact

cattt

agta

gatg

agaa

gaat

gaga

cattg

aaaa

catg

caca

gtgg

agg

tggg

aatg

aaag

ccag

ctct

ccaa

ctct

ccag

tcct

ctttc

ctgt

cact

gcat

cagg

ctgc

aggg

tgaa

gggg

aggt

ctgg

gata

caaa

gaga

actta

gag

gtgg

agca

gttg

gattc

tgtg

cagt

gcta

ggag

ggag

gaga

gggg

ttgga

gtag

gtgg

gaag

tagg

cctc

cttc

agttt

ggat

agca

cttc

cctta

acc

caat

gact

ctag

tggg

aggg

tgga

ggga

tggg

gatg

ggaa

ggga

gcct

ggga

gtga

ggag

gaaa

ggca

aact

ctgt

cttc

cccc

aggg

gagt

caat

gaa

tagt

acc

1077

3474744

NO

ttagt

gtac

ccttc

ggtg

acag

gtaa

gggc

tttct

gaaa

cgca

ttgtc

ttttta

ttata

gcca

ttcta

gtag

taag

gtgt

gaag

tggt

atct

cata

gtgg

tttgg

gtt

gtat

ttccc

tgat

attg

ggat

gttg

1078

2489696

NO

atgc

agtta

caaa

atcg

gattc

agca

tcag

aaca

g1079

3195395

ARRDC

NO

gtga

gtcg

acag

ccag

ggct

tggc

a1

1080

3497381

—N

Ogg

tgga

cagt

gatg

gtttc

aaag

ggga

aa1081

3130174

GSR

YE

Stc

attg

ttggt

gcag

gtta

cattg

ctgt

ggag

atgg

cagg

gatc

ctgt

cagc

cctg

ggttc

taag

acat

cact

gatg

atac

ggca

tgat

aa1082

3180421

—N

Oga

gagg

tgga

tctg

tctg

gact

tcag

gctg

tgag

aacc

tcac

agca

caga

tagg

atgt

gagc

tttac

ccct

tgtg

ttcag

gccg

ctcg

cacg

gagt

cagc

ttgc

ggaa

gcac

gttc

ccag

gcct

gctc

tgcg

tgta

atgg

tgga

att

1083

2384882

GALNT

YE

Sga

agtc

ggtg

aagc

acat

ggat

ttgtg

cctta

ctgt

ggtg

gacc

gggc

accg

ggct

ctct

tata

aagc

tgca

gggc

tgcc

gaga

aaat

g2

1084

2601621

NO

tctc

ctgc

ttcct

agac

gaaa

tcta

agca

atat

tttat

ccac

ttcttt

ttagt

aaaa

gaaa

taca

tattg

cctg

ttggg

gtca

tgag

ctat

gtag

ggaa

tgaa

aaaa

tttt

ttaaa

ggag

aatta

taaa

gaga

agga

ggat

acaa

gaga

aagg

aaaa

cgaa

agct

ggtg

ggaa

gttg

agcc

atgt

ttatc

tcta

gtgg

aatc

ctta

ccttg

tgttt

1085

2624206

ITIH3

NO

tgga

tggc

ccgg

atttt

atgg

catc

tgga

ac1086

2626149

RPP

14

YES

tcaa

gattg

tgga

gttg

gact

gaat

gctg

caca

gttc

aaac

agct

gctta

tttcg

gctg

tgaa

ggac

ct1087

3466862

NO

tgtc

actta

gtct

actg

ccag

tcta

ctgt

ctgt

gcca

ccat

ggga

aattg

catg

agttc

agac

ctgt

gaaa

aatc

agaa

taaa

gata

aaaa

caca

tttttt

gaag

gtta

cgga

aattc

ttaag

atct

tggt

tttct

tgaa

ctta

ctac

tagt

acta

ctga

tttag

aaat

ggcc

tacc

tcct

atag

tagg

aaag

ggca

aaga

aaac

aata

gtt

aata

ggga

aggc

ttaaa

ggag

cttg

aggg

ctgt

cctg

gcaa

taat

agaa

gaga

tcct

tgttt

tttaa

agga

gagt

taat

gtac

aaag

attc

tgaa

aagt

ctag

aaa

catg

ggta

aaat

tttta

tgat

tgcc

gggc

gcgg

1088

3400762

NO

tcaa

tgac

cagc

gtag

acag

agct

agta

gcag

caat

gaga

tgag

tgac

taga

gagg

taga

gaga

aaac

cagg

aaag

tgtg

gagt

catg

gaag

ctaa

ggaa

gatg

gtgt

tggg

aata

gagg

tggt

gaac

agag

tccc

ctgt

tcttg

ctga

tagg

agag

gtca

aatg

agat

aagg

acag

aggc

gtgg

ccttt

ggat

tccg

aga

tgtg

ttgat

cacc

ggtg

cact

tggc

aagc

atgc

ca

1089

3511392

KIAA05

YES

aatc

ccgc

ttccc

tgta

cttta

tgaa

tatg

actg

ggaa

aagt

ggct

tcttt

gtgg

acttt

tttga

tatc

ttccc

aaga

acag

ccaa

tggc

gtttg

gcac

ccttt

tgtg

64

acag

tggc

accg

ctgg

gaag

tcct

ctca

aagg

tcaa

gtgg

ttctc

catg

agca

gca

1090

3762555

—NO

tgca

catg

tggt

aaga

gcat

ccag

cagg

aaag

aaga

gggc

aagt

tgag

tgtg

cgtg

ggca

tgaa

ggat

tcac

tgta

cgca

tccc

agcc

ctgc

tcat

ctca

gccg

catg

gact

gggc

acac

attta

agca

tgga

gggt

ggtg

gtttt

cagg

ctgt

tttct

agag

ctgt

agaa

ctca

aatg

aaat

gctc

tgag

tctg

tgag

gggg

ggag

gagt

caat

aaag

ggtg

gcta

agtg

catg

gagt

ttgag

gtac

ccgc

tctg

ctgt

aacc

1091

3853067

ILVBL

YES

gcttg

ctgc

tctc

acgg

gaga

acga

ggat

cagg

tggt

caag

gt1092

4015570

—NO

ttcat

ggttg

ccta

gtgc

tgcg

agga

gtgg

ggaa

tggg

gaat

gagt

gctta

atgg

gtat

gggt

ttcttg

gggt

gatg

aaat

gttc

cggc

acta

agttg

tggt

aatg

actg

catg

acttt

gtac

taaa

acta

ctaa

attg

taca

cttta

aatg

ggtg

aattg

tatg

gcat

atga

gtta

tt

1093

2458440

NO

tgca

ctttt

gcct

ccga

actc

tcgt

gttta

atta

1094

3333734

SLC3A2

YES

atgg

gttc

cagg

ttcgg

gaca

taga

gaat

ctga

ag1095

3379257

___

NO

ggcc

gtgc

agct

tcttg

acaa

attg

caaa

ggtg

ccca

cgag

tttcc

aagt

1096

3662461

NLRC5

YES

ctca

acttg

atca

cgag

gttc

ctga

cacc

gtcc

gagc

tcct

ttttg

atct

1097

3670791

___

NO

gtgc

aggt

ctaa

tggg

ctcc

ttcct

tc1098

2689662

___

NO

ctca

tggc

aact

tcttc

cgct

tcct

agttt

ca1099

2698749

XRNl

YES

gctg

ggat

cact

atgg

aagc

aact

atgc

attg

gggg

ca1100

3940626

—NO

tgca

ggct

ttacc

tatg

accg

aaca

tgca

tgga

aatg

ccct

ctga

tgga

ctca

ggca

tgat

acat

acat

caaa

cagc

cttg

cacg

gtgg

ta1101

2577438

—NO

gaga

gcat

ggct

acaa

cagc

aata

tttct

ggaa

acca

gtta

tcgg

ggga

attc

acag

g1102

2885881

...

NO

atgg

actc

atcc

caga

acaa

tcct

cagg

cact

ccga

aatg

caga

tgcc

c

1103

3473848

TA

OK

3Y

ES

atgg

ctcc

agag

gtga

tctta

gcta

tgga

tgaa

ggac

agta

tgat

ggga

aagt

tgat

atttg

gtca

cttg

gcat

cac

1104

3721713

NO

agaa

cctg

gtcg

tgtc

ttgag

aacc

cagt

ccaa

acag

aatc

aggc

ctct

ggac

tggg

agca

acac

tccc

ttcac

ccgc

aaag

attc

agga

aaag

cacc

ccaa

ggac

aagg

aaac

caat

gagg

tctg

ggct

agct

ctgc

agct

ttagg

atac

tagc

tcta

ggga

agga

tttttt

ccttt

ttaaa

cagc

gtat

cact

ctgt

tgcc

tagg

atgg

agca

caga

ggca

ccct

cata

gctc

actg

cagc

ctca

aact

cctg

ggct

ctgg

cgat

cctc

ccgc

ctca

gcct

ccca

agta

gctg

agac

caca

ggca

cgtg

ccac

catg

ctcc

tagg

gaag

gagc

ttgag

aaga

aact

gcca

ggag

tgaa

ccag

ggct

ggct

gctc

tgtg

atgt

tctc

tccc

cacc

tccc

ctcc

agct

ctca

acttg

gtgg

cagg

gccg

gcac

cctg

ctct

ccct

ccta

actc

ccag

cctg

ctgc

tgcc

ccct

tctg

ggac

ccta

atttt

ctgg

acttt

gaga

aatg

ggc

tgcc

cctg

gggg

tgcc

tcca

agag

ccca

tttga

ggga

tcgg

gtgg

ggct

gacc

tctc

tgtc

ttcttt

ggat

catc

gcct

tctc

acac

tgtc

ctcc

ctct

tgat

tct

gaaa

aatg

gtcc

tgct

gccc

atgg

agaa

ccac

agta

agat

agat

ttctc

atgc

agct

agtg

aggg

gact

tc

1105

2924660

...

NO

acca

tgttt

ttgcc

tcca

gtct

gtc

1106

3242466

.-.

NO

atgg

ctat

ggga

atat

cggg

agttg

agga

agaa

aaag

gctc

cagt

ggca

ctga

ag1107

3268238

BTBDl

YES

agca

gctc

acca

ccgg

ctgc

gaga

agtg

gctg

gaaa

tgaa

cttg

gttc

ctct

aggg

ggga

cgca

gatc

cacc

tcca

caaa

atcc

caca

ggac

ctgc

tcc

6ac

aaag

tgct

g

1108

3293847

SPOCK

NO

tgtg

gcat

gcgc

tgac

aaat

gtgt

ccttg

atcc

acac

tgct

cctg

gcag

agtg

agtc

accc

aaag

gccc

cttc

ggcc

tcct

tgta

gctg

ttttc

tttcc

ttttg

ttg2

ttggt

tttaa

aata

cattc

acac

acaa

atac

aaat

tgac

aggt

caaa

atcc

a

1109

2416565

JAKl

NO

aatc

ttgct

ttttg

tggc

ctgg

ggat

tggc

tgtg

tgat

cagc

attg

aaat

gggt

tgttg

cagt

ttgaa

gtct

ggaa

gggg

tatg

tccc

tggg

ttcta

attc

tttcc

ctct

aggt

ttctg

tact

cagc

tcag

agtc

taga

atgg

tagc

tttta

ggat

tgga

aaag

acca

aagt

tacc

taat

tcaa

ctct

ttcat

tttttt

ttcag

tgga

aaaa

ctaa

tac

ccag

aaaa

ggga

agag

agtta

accc

aaaa

atta

catc

tagt

gaat

tgtc

tgat

tagc

tttac

aattg

aggc

attg

taga

gctc

tttga

ggca

ttagt

cttg

gtt

gtct

gagt

gcct

ggct

atta

aagg

ctgt

ctttg

cctg

ttccc

tcttt

ctgt

tagc

tgcc

tgga

agtg

cagg

gttg

cttc

acttt

tagc

acct

tgac

tctg

tacc

tgac

atgg

tgct

tcaa

cagg

atat

tgc

1110

3198506

—NO

gtct

acgc

agct

gcca

taga

ggag

gggg

attg

tttgg

gaga

ccttc

ccgt

ggca

gaat

caaa

gctc

gtag

ttcag

ctgc

ggga

atct

ggtg

tact

taa

mi

3384336

RAB30

YES

ggga

agac

gtgc

ctcg

tccg

aaga

ttcac

tcag

1112

3649726

—NO

ttgtg

caac

agaa

aact

caac

ccaa

1113

2732288

—NO

aggt

ttagt

tgtg

tggc

cgta

atca

catc

caac

acca

agtc

ggcc

aacc

atat

gtga

gctta

atcc

caca

gaat

tctta

tgtta

gacc

tccc

tcttc

agat

aata

gag

gaga

tttttt

ttaag

tata

cgtg

caca

gagg

aagt

gact

tcttt

ctgc

gcac

tctg

ttgtc

actg

gaa

1114

3291868

—NO

tacg

agga

agtg

acca

gtgt

tcat

ctga

aacg

gatg

ccttg

tttct

caga

aatg

tcat

tctc

tttat

ttcat

cttc

gtag

ttctg

tgcc

ttctc

tcag

caat

ttctg

attt

cttta

tttac

tgcc

acac

agat

gaca

aatg

acat

gcat

gtcc

atga

tacc

cttta

ctca

attc

acat

gcga

tttcc

aagg

ctgg

ctat

aattc

ccaa

a

1115

3572359

—NO

gtgg

gggg

ctgt

aatc

taca

aaag

ccat

cttc

agta

ccag

gttta

attc

catc

attg

tttttc

gggt

tttag

gtct

ctgg

acta

ttgtc

cttta

acaa

caac

a1116

3613987

—NO

gcct

gcct

gttc

atgc

caaa

tata

catc

ctca

caat

gcac

agta

caca

acat

gggc

acat

aggc

acag

aggc

tatg

ccgg

1117

3768275

NO

ggct

ttgaa

gggc

aact

gacc

aact

ttttta

taca

taaa

ggat

ataa

acta

caac

tattt

tccc

actc

tgtg

taga

atgt

ggaa

cgga

aaca

gtgt

gtgg

caca

cttt

aaat

gatg

ctaa

acttc

taca

gtgt

gtaa

actg

gcttg

ttcaa

gagg

ccaa

agtg

cttc

tgttg

agaa

acac

tgat

gacc

aatc

tcct

ctttg

tggt

cctg

tga

tact

gtga

aata

tata

tttga

tcttc

ctcc

ctgt

ttccc

agca

taca

attc

ctaa

aacc

ctca

gaat

ctgc

aaaa

taag

atttt

ttttta

atgc

taat

gattg

actg

atg

gctg

gagg

ctcc

taga

gagc

ctca

ggat

tggg

gctg

attc

tcag

ggct

ttc

1118

2367

980

RA

BG

AY

ES

gacc

atct

tctc

cagg

tgga

ctac

ctga

agaa

gata

gtgt

tttat

ttaat

aaac

tgac

ctac

ttagg

atgt

atga

aggt

ttcttc

ccca

cgta

atga

agta

gagg

cPl

Lttt

acgg

gcaa

tggc

aacc

atg

1119

3063

344

ZN

F394

YE

Sgt

gtga

agaa

tgcg

agaa

gagc

ttc11

2031

4713

7—

NO

tttag

gaaa

aggc

tgct

atac

tgtg

gacg

aagt

ctca

gatc

agaa

1121

3737

089

CC

DC

4N

Oac

ggga

cgct

ttctc

tggg

atgc

attg

agtc

aggg

aata

gaag

atgg

ggtg

aatg

atgt

ttctg

accc

acag

accg

ttggg

atgc

ttttg

ctgt

cact

ttccc

a0

tcat

gctg

catg

aggc

atga

cagc

agct

gt

1122

2686

311

FIL

IPlL

YE

Stg

ccaa

gcat

gcga

tattc

agag

tctc

ccca

gacc

ggca

gtca

tcat

ggca

gtttc

agcg

ttcaa

acag

caat

agct

caag

tgtg

ataa

ctac

tgag

gata

ataa

aatc

caca

ttcac

ttagg

aagt

cctta

catg

caag

ctgt

agcc

agcc

ctgt

gaga

cctg

ccag

ccct

tcag

cacc

actg

cagg

ataa

ccga

actc

aagg

ctta

atta

acgg

ggca

ct

1123

3307

401

NO

gcca

ctct

gctc

aaag

ttggc

acga

gttg

gaat

gtaa

tcac

catc

tctg

cact

caag

gcat

gcag

aaat

gaag

tcta

cctc

agcc

ctca

aaga

cctc

acct

gag

aaaa

agac

aagg

ctcc

aaac

agaa

ggca

aaac

agaa

tgag

cata

gaaa

gaga

ccac

tttttc

acat

acct

ttaca

aagc

actg

ctca

cccc

tcct

taac

ctcg

caca

gaca

gagc

atgg

ggcc

tcag

tgtc

actg

ccac

tgcc

accc

tccc

actg

acta

gctg

tact

ctct

ga

1124

3648042

CIITA

NO

ctct

gagg

acac

taac

cacg

ctgg

acct

tgaa

ctgg

gtac

ttgtg

gaca

cagc

tcttc

tcca

ggct

gtat

ccca

tgag

cctc

agca

tcct

ggca

cccg

gccc

ctgc

tggt

tcag

ggttg

gccc

ctgc

ccgg

ctgc

ggaa

tgaa

ccac

atct

tgct

ctgc

tgac

agac

acag

gccc

ggct

ccag

gctc

cttta

gcgc

ccag

ttggg

tgga

tgcc

tggt

ggca

gctg

cggt

ccac

ccag

gagc

cccg

aggc

cttc

tctg

aagg

acat

tgcg

gaca

gcca

cggc

cagg

ccag

aggg

agtg

aca

gagg

cagc

ccca

ttctg

cctg

ccca

ggcc

cctg

ccac

cctg

ggga

gaaa

gtac

ttcttt

tttttt

atttt

taga

caga

gtct

cact

gttg

ccca

ggct

ggcg

tgc

agtg

gtgc

gatc

tggg

ttcac

tgca

acct

ccgc

ctct

tggg

ttcaa

gcga

ttcttc

tgct

tcag

cctc

ccga

gtag

ctgg

gact

acag

gcac

ccac

catc

atgt

ctgg

ctaa

tttttc

atttt

tagt

agag

acag

ggttt

tgcc

atgt

tggc

cagg

ctgg

tctc

aaac

tcttg

acct

cagg

tgat

ccac

ccac

ctca

gcct

ccca

aagt

gct

ggga

ttaca

agcg

tgag

ccac

tgca

ccgg

gcca

caga

gaaa

gtac

ttctc

cacc

ctgc

tctc

cgac

caga

cacc

ttgac

aggg

caca

ccgg

gcac

tcag

aaga

cact

gatg

ggca

accc

ccag

cctg

ctaa

ttccc

caga

ttgca

acag

gctg

ggct

tcag

tggc

agct

gcttt

tgtc

tatg

ggac

tcaa

tgca

ctga

cat

tgttg

gcca

aagc

caaa

gcta

ggcc

tggc

caga

tgca

ccag

ccct

tagc

aggg

aaac

agct

aatg

ggac

acta

atgg

ggcg

gtga

gagg

ggaa

cag

actg

gaag

caca

gcttc

atttc

ctgt

gtct

tttttc

acta

catta

taaa

tgtc

tcttt

aatg

tcac

aggc

aggt

ccag

ggttt

gagt

tcat

accc

tgtta

ccat

tttgg

g1125

2568862

NO

tcttc

ttcta

gcag

tgct

cagt

gggt

1126

3405549

DD

X47

NO

tggc

gtga

gcga

gata

aacc

tcct

aaca

gtag

gtttg

taca

ataa

ggcc

atag

ggca

ccga

tgcc

tgttt

ccat

aattg

ttgta

atttt

atgg

gcttt

gaag

tgtt

gctc

taga

tact

tact

ttctc

ctttc

aggg

tagc

gaga

ggct

ccca

ttaga

atat

ttcat

atgt

acct

gtct

ggttt

gcaa

gctg

ttgag

ttgat

ttattc

agcc

ctag

tggt

aata

atga

ctc

1127

3479

324

AN

KL

EY

ES

aact

gaag

gagc

ggat

caga

gagt

attta

211

2837

3614

0—

NO

tgga

tgtc

tact

ttgca

cgct

gcga

ttggg

agag

ctgt

cccg

ctgc

atgc

gttc

cctc

tgta

atttc

ctca

gagc

tcac

atac

gtac

ctct

ctca

cgag

tgaa

ctca

gattt

tcca

ttgttt

tgct

ttattc

tatc

atttg

ctttg

tggt

tttgc

tgta

aata

ttgaa

atct

taat

catc

atcg

agag

gcac

agcc

aagc

tttcc

agct

ctcc

acc

cccg

tggc

ccat

ccaa

gtct

gttc

atct

ggta

acttc

tgttg

tctg

ggac

ggca

gcaa

gaag

atgc

cggg

gcttg

cctg

gagt

cctg

gcag

agga

gtgc

cact

cact

tttgc

ctag

ggtc

cagt

tggg

gctta

aaaa

atat

ttgga

gaga

agag

taat

gagg

atttt

ttgtg

tttcc

taga

cattt

tatg

catc

tattt

ttgta

aaat

cac

cttc

gcta

acttt

cacc

aagc

acttt

gagc

acag

tgga

acttc

agaa

gcac

aacc

agcc

taac

ccca

gaat

ctca

ggtg

gcac

agct

agaa

attg

agtc

cctt

ccta

ggac

actg

gccg

tggc

cttc

aggg

tgac

cagt

cagt

gcca

ccgg

gttg

gcat

tggt

gtta

caga

cagg

cctc

tgaa

gaca

aacc

gagc

accc

cag

cggc

ccct

caaa

ctaa

gcaa

ggat

ctttt

ttctg

tctg

cgct

ccct

gggg

caag

gtca

aagg

tgga

cccg

ccca

ctgt

gggt

caat

tcct

tcga

aaag

atgg

gacc

cgca

cccc

cgcc

acag

gctg

gccc

cccc

ccac

ccat

gggg

aagg

tggt

gtgc

tgct

ggct

ctga

ccat

actc

ttttg

gaaa

ttgag

aagg

aaag

cattg

agtg

ggac

ctaa

tccg

gaga

agaa

atta

aaga

ccag

aaaa

agaa

ggaa

gctg

ggaa

tgaa

actc

aaaa

tgca

cttg

aacc

tgga

agcg

gcaa

ccct

cagc

tctg

cgcg

gccg

agcc

tcag

caag

agttc

gttt

1129

3954

953

NO

catg

gtct

aacc

acag

aggg

gaat

acta

ctca

gcaa

taca

aagg

agtc

tctc

ctaa

tacg

tgca

acaa

cattc

atga

atcc

caaa

aact

ttatc

tgga

gcca

agc

caga

caca

aatg

tgta

cata

cagt

acgg

aatg

acttc

agat

tctg

aaaa

aagg

caaa

tctg

acca

attg

aggc

agaa

agca

ggtc

agtg

gttc

ccca

ggtc

tggg

actg

gggt

gggt

tact

gata

gcaa

atgg

gcat

gtgg

gtgc

cttg

gggt

aggg

taaa

ggttc

catc

ttgat

cacg

gtgg

tgttt

ccca

agtg

tata

4-

1130

2396

759

FBX

O2

NO

tcga

gggt

agat

aggc

ctta

actta

gtcc

atag

cgtc

ctca

ccttc

ccca

agcc

acac

atcc

tcct

ccca

tccc

ttgct

ccga

tccc

agcc

cctg

agca

ggga

gaga

gaag

ttttg

ttggc

atag

gtttg

ctta

ggta

gccg

gcttc

taga

atgt

agat

ccgt

gagg

gcgt

gagc

ttgga

ctgg

accc

actg

ctga

ttccc

tgca

cct

agca

cagt

gcttg

ccac

aaag

tggg

ctct

ca

1131

2519

281

ITG

AV

YE

Sgg

tgag

cggg

acca

tctc

atca

ctaa

gcgg

gatc

ttgcc

ctca

gtga

agga

gata

ttcac

acttt

1132

3640

619

___

NO

tctg

ttgtc

tcgc

ccttg

ctct

gctc

ctac

ttcac

ccat

cttc

tgag

atcc

aagt

caaa

atca

tctg

cacg

1133

3976

861

HD

AC

6Y

ES

acct

aatc

gtgg

gact

gcaa

ggga

tg11

3440

4829

3—

NO

gggg

taga

acaa

tcaa

gctta

ttcct

aagg

atttt

ctttt

gaca

aata

aatg

ggtg

gtag

tgttg

tttat

tgag

atag

gaaa

aact

atgg

gagg

aaat

gattt

gaa

gtgg

gtgg

tttga

aata

aaag

ttttg

tttaa

atat

gaga

tgat

tgat

tgac

attta

tgtg

gaga

aatc

cgaa

ggtc

aatg

gcat

ttaag

agac

tcat

ggtg

aggc

cag

ggct

tcag

gtat

ttatg

ttggc

agca

gcaa

tacg

tgta

gtgt

gtta

aattc

cagg

gcgt

g

1135

2393

657

KIA

A04

NO

ccct

gtttg

tctg

agcc

ctttg

gaga

tttag

gttg

agtc

atga

gaac

cggt

cattg

gaac

atac

acttt

atta

tgtta

caaa

aaca

aaaa

tccc

cact

gaaa

caca

95

gcta

aaaa

aata

acac

atttt

ccca

agat

taca

ttacc

aaaa

acag

ttgtta

tgtc

attg

gagg

gcgt

ccat

taat

actg

ctcg

gaga

agca

cgat

ctta

ca

1136

3389

355

CA

SPl

NO

aggt

ttttg

gaat

tatg

tctg

ctga

1137

3584

178

NO

attg

tagt

ttgaa

gagc

tgcc

cttg

ggaa

ctca

tggg

acag

gcat

cagg

cctg

gaat

ggga

tgga

caag

tggg

gcct

ccag

gaga

agga

gcat

tgca

ggag

atgc

tgga

gagt

gggg

agca

gtac

gtgc

agca

gata

gggg

a

1138

2365

984

MPZ

Ll

YE

Stc

acca

gtta

agca

ggct

cctc

ggaa

gtcc

ccct

ccga

cact

gagg

gtct

tgta

aaga

gt

1139

2468

456

NO

aaag

caat

ctta

acag

tgag

ggct

atga

aacc

gttg

aaaa

ttctc

ccaa

ggga

agtg

atgg

aaac

ctcc

ttgct

tgag

tcat

ttcaa

agtc

gaca

aaac

aacg

aaaa

atac

atgg

aggg

aggg

atcc

tgta

gtgt

tggg

gagc

agac

tcga

tgat

ttcat

agttc

ttttc

tgtc

tctg

atttc

catg

ttctg

tgaa

atag

tattg

cagc

taa

gaaa

catg

aaat

ccttc

actc

cgac

agta

tg

1140

2954

656

YIP

F3Y

ES

acct

gcttc

ggct

actg

gctg

ggag

tctc

atcc

ttcat

ttact

tcct

tgcc

tacc

tgtg

caac

gccc

agat

cacc

atgc

tg11

4134

9918

9IT

GB

Ll

YE

Sag

atgg

cata

ttgtg

ctcg

ggga

agg

1142

3102

170

PRE

X2

YE

Sga

agga

tatta

ttaca

gaga

caat

gtttc

tgtg

gaag

aattt

caag

ctca

gata

aatg

cagc

ctca

ctgg

aaaa

ggtc

aaac

agta

caac

caga

agct

c11

4331

5137

2-_

.N

Oca

ggca

ctgt

atca

ggtg

ctgc

gtac

ttctg

ctag

ctca

tctc

acct

ggtc

atgc

cgct

ctga

1144

3153

640

-_.

NO

ttcttc

cttg

atgc

agga

tctg

aggt

tgaa

g11

4537

0835

1-_

.N

Otc

acat

tctg

gggt

taga

aggg

gccc

aatg

gatg

ggaa

ttcttc

atat

aaaa

gagg

aaat

gcc

1146

3793

991

...N

Otg

caac

aatg

ggag

ctttt

taac

tagt

ctct

gtaa

ggcg

ttgtc

atca

catc

tg11

4728

4018

6D

OC

K2

YE

Sca

tgag

ttcat

gagt

gaca

ccaa

cctc

tcgg

agca

tgcg

gcca

tccc

cctc

aagg

cgtc

tgtc

ctct

ctca

aatg

a11

4829

4591

3C

MA

HN

Ottg

cctc

ccgg

agtg

tgta

acca

catg

agaa

atag

aggg

aagg

ttctg

tcct

taag

aagt

taaa

agtg

tgac

tggg

aagg

taaa

acat

actta

ttaag

ggtta

acta

gcat

catg

ccat

tctg

tgtg

atgg

tgag

tttgt

gtgt

gtgt

gcac

atgt

gcgt

gagt

acac

acat

atac

attta

aaaa

ggtc

ttgaa

tata

ccaa

aata

ttat

gtct

aggt

gatg

ggta

gcttg

tata

tttttt

ctgt

atcc

ttgtc

tgtg

tttgt

caaa

tttta

taga

aaca

ataa

cagt

aaca

gctc

tctg

acct

tcta

ccct

gtat

gttc

tgc

gtcc

tgtc

taat

tcct

caag

ttcct

tcac

tgcc

tgtc

actc

tgat

gcttg

ctat

atat

cagc

ccat

cctg

ctttt

tgttt

ctta

gacc

caaa

gtgt

caag

tgca

cac

ctgc

cctg

ggtc

tttgt

gtttg

ctgt

ttcca

tttcc

tgga

gtgc

agct

ggcc

ctga

tttgc

atgt

gacc

agca

1149

3706

405

PAFA

HY

ES

tcgt

cact

ggca

gcgt

agat

caaa

caIB

l

1150

3898

481

—N

Oat

ggcg

gcag

agta

tctg

gttc

tctt

1151

3962

245

NA

GA

YE

Stg

ctct

tgct

ggga

catg

tggc

ccag

gtgc

tgat

gctg

gaca

atgg

gctc

ctgc

agac

acca

ccca

tggg

ctgg

ctgg

cctg

ggaa

cgct

tccg

ctgc

aaca

ttaac

tgtg

at

1152

2877

309

BR

D8

YE

Sca

caga

gcca

tggt

ccat

ccga

gaga

agct

atgt

tt11

5329

7372

0—

NO

gtttg

gtgt

ctgg

tact

taga

gctc

cctg

aaac

tgtg

gtgt

tt11

5430

9176

2FZ

D3

YE

Saa

tcat

ttgcc

tctc

ggcc

acat

tgttt

acttt

tttaa

ctttt

ttgat

tgat

gtca

caag

attc

cgtta

tcct

gaaa

ggcc

tatta

1155

3418

179

—N

Oct

gagc

tcat

ccag

taaa

actc

tcaa

aaga

tgaa

taga

tgcc

ctttt

ccttg

agga

gcct

tctg

cctg

atttc

tttgt

cact

gagt

ttggg

tccc

tggt

tgga

gtgg

cagg

agga

aggg

gtcc

acca

cgtc

ttctg

ac

1156

2685

385

NO

tttgg

tgtc

tttct

gaag

ggat

tcgg

cccg

gag

1157

2912

792

NO

ggat

gaaa

tcgt

gcac

gtcc

ctct

tcgt

ccct

ctca

ggac

agaa

attc

ttttg

tcca

gcat

atat

ctat

gttg

cata

tacc

acca

gcca

atta

gtca

ctta

gtag

ctgg

tgttg

gtta

tgag

atca

actg

tcat

agta

tcac

agtg

cttg

tttca

ggta

accc

ttatg

ttattt

aata

gtgg

ccca

agag

tgca

agag

tact

gttg

ctga

caat

ttgga

ttcac

gaga

agc

1158

3590

727

JMJD

7Y

ES

tctg

gtat

gaca

tgga

atac

gacc

tcaa

III

JMJD

7-PL

A2G

4B11

5923

6302

8_.

_N

Oga

aacg

ccgt

cctg

cgga

aaca

tcca

ccat

ccgg

acc

1160

2374

733

—N

Ota

gaga

ctgg

atca

taga

agga

gttg

tttgc

catg

ctta

ccct

taaa

ggct

ttctg

agca

gtca

tcct

ggga

tgga

cagg

gcag

ggag

tgga

gaga

ccag

cga

gcag

gtttt

tgtta

cggt

tcga

gtga

gggt

tgaa

caca

ggca

gtgg

tggt

ggag

atgg

gttg

cagg

gata

atct

tgag

agag

attta

ggag

acaa

gattc

acag

gttg

1161

2448

301

TPR

YE

Sga

gattc

agcg

attg

cagg

agga

cact

1162

2596

900

___

NO

gaat

ggtg

ggaa

atgt

atgc

ttgac

tcaa

aaca

gcca

g11

6327

1380

5Z

NF5

95Y

ES

ctat

atgt

tctc

ctttc

agcc

aaga

cct

1164

3878

694

—N

Ogg

ggtg

tctg

cgtg

ggga

gaaa

tcag

ttgtc

ggca

tttta

aatc

tctg

gata

atga

g11

6524

3463

4A

RN

TN

Ocg

gctg

ttgat

acga

ttgtc

tgtta

tcga

acac

attc

agtg

ataa

agct

gggt

tact

gctg

ctttt

ggtg

ctct

cacc

ttatc

tgga

agat

ctgc

aaac

atta

ccta

aata

ggct

ggca

agat

aaac

acttt

ctgg

aacc

cgag

acttg

gcca

taaa

gata

atgc

tgca

tttttc

tgtc

agaa

tcac

atat

gatg

tgtg

ttctg

taga

ggtta

tttct

gcat

ggaa

actc

aact

tcttg

gatta

gccg

tccc

agtg

aaaa

tcct

cattg

ttgga

gtgt

aaac

caaa

tacg

aagc

cctc

ttgca

aagt

agcc

tcttt

cat

ccca

tact

caaa

atac

ccag

tttag

caag

caac

tgag

attta

agtc

tctc

tggc

ccta

agag

gtttt

tcct

ctttg

ctcc

ctcc

aatc

ttgag

attg

ggttt

tgct

ttaga

gtgc

aagt

atca

taat

tccg

tatg

atag

atgg

ggcc

tgga

cacc

catc

tcaa

cagg

gtca

cttg

gtaa

ttaac

aata

gcca

tata

aatg

cgga

taca

ggtt

acta

ccct

cacc

cttta

ccttc

ctca

ggta

acag

tcgt

agat

acca

gcttt

tttttt

tttttt

tttaa

attg

gcttt

ggcc

agta

gcta

aagt

gcaa

gact

gaat

taat

gag

aaga

tata

ttaaa

tgta

gtca

tagg

ggac

tgag

gagc

aagg

gtgg

ccttg

aaga

ggcc

aaag

gaat

gtcc

atttg

ctga

gtttc

ccttc

ctta

tgtc

tcca

gtc

tggt

gcca

ggta

gtgg

agta

aaaa

agga

gaca

gttta

tttttt

tattc

tatg

tgca

cact

taca

gtat

acat

atat

attta

tatc

acaa

tttac

gaaa

ccaa

aaag

ttgag

tttcc

aatg

gaac

ccttg

tttttt

aata

atcg

acttt

ttaaa

tgtg

atca

ggac

tata

atat

tgta

cagt

tatta

tagg

gcttt

tggg

gaag

ggga

ggat

agc

gaga

agat

gctc

tggg

ggttt

tgttt

ttgct

tttcc

ttcag

ggttt

tattt

ttgac

tgttt

tg

1166

2502

158

—N

Otg

cact

ttccc

agcg

tttct

gtct

gc11

6725

1134

8—

NO

agac

aaca

gtaa

agaa

atac

cagc

aattt

gaag

ccct

gtcc

ctga

atcc

tact

cctg

ttgcc

ttcat

atcg

agag

ttcca

agtg

ttggc

ctgc

agtta

agttc

tga

1168

2697

262

DZ

IPlL

YE

Sgg

aact

gcat

gaag

agca

catg

gctg

a11

6938

2972

7G

PIN

Ogt

tctc

tgcc

aagt

gctg

gcca

gagg

cgcg

tgtg

ttggt

cctg

gtcc

cccg

ctttc

tccc

ccac

tgtc

ctgt

ccct

cccc

tccc

cgtg

cagc

tgct

cag

1170

2566

885

___

NO

ccta

cgag

gtcc

atgg

cagc

gggt

acttg

aagg

attta

1171

2644

609

NO

ggct

ttgag

gatc

tctg

tgcc

acttt

g

1172

2681

773

FOX

PlN

Otc

ctta

cgag

gcta

gaga

ttttc

tgac

aaca

gtat

gtta

gtttc

atttg

gtcc

gtga

atgg

agat

ggca

gcaa

atat

tctc

agac

cctc

ccag

atct

ggct

aaga

catc

ccct

tattt

agga

acga

ccct

cccc

tggc

atac

ccta

ctct

ccat

cgcc

tgttg

gcaa

taaa

cgtg

ccttg

tgga

tattc

ctta

aaag

ccttc

ctgc

catc

cct

ctag

cagt

cact

gtaa

agttc

aaat

ctca

aaga

tgct

tagg

agcc

aaga

ttctc

tctg

ctcg

tgcc

cagc

agcc

cctg

ctgt

gagc

tcac

tgcc

ttccc

cag

cacg

acct

ccta

ggct

gctg

ccttc

ctttc

tgttg

gagt

ctgg

agtc

aggc

taac

tcct

aaaa

atct

gcag

agag

gtct

ctgg

aggg

agga

ccca

agcc

tgtt

acta

ccta

agcc

agaa

tttta

cacc

tagt

ttcct

tgaa

taga

gaag

tcca

accc

caga

ggtg

tgca

caca

cacc

cgcc

ctgc

aaat

cagt

gacg

ggga

gaa

agcc

tgac

ttttc

ttggg

ttttg

ctag

tggg

ggaa

attg

ctca

tttgg

aagg

gcac

cagc

aagc

tta

1173

2941

811

NO

gtgt

cgct

tttat

tcta

actg

ctgg

aact

atttg

ttgta

cctc

tttct

gaag

atca

gtttg

gggc

taaa

ttaca

agct

ccat

cagc

acag

gggc

catg

gctg

cctc

ctg

actg

ctgt

aggc

tgag

cact

tggt

agag

catc

agcc

c

1174

3037

970

NO

tcac

ctaa

aagg

acga

atcc

atct

gcttc

tgtc

tctg

gtac

tgag

ggct

tttta

gattc

cgga

ggct

ttctg

aaga

1175

3235

439

SEC

61A

NO

acac

tttga

cgga

tcgt

ttttg

tcag

atga

211

7636

7057

6-_

-N

Occ

aagg

tcac

acaa

tacg

aggt

gggg

tcag

aatg

caaa

ccca

ggca

gtgt

gcct

acct

agcc

caga

ctct

taac

cact

aaga

tgtc

acta

aaga

agca

1177

2682

104

—N

Ogg

agat

ttgga

gtac

ttgga

gcat

ggag

1178

3809

910

—N

Ogg

gacc

ttgtc

cctc

tttgc

atgg

aggg

atgg

tttct

ttagg

tcct

gggg

gata

gccc

aggc

cact

tcca

ctct

gaag

atct

gtgt

tcttt

atca

gtct

ttcaa

tct

agta

tattt

gcat

ttaat

aggt

gaca

aatg

ggcc

tgga

agct

gtgg

tggg

gatg

gagt

ggga

aacc

agct

ctca

gtct

gaca

ttgac

tcct

ggag

ggga

gggt

cacc

tctg

ttcct

gggc

agcc

tttca

gtgg

cgaa

ggcc

acca

tccc

ccac

agcg

tgat

tgag

aagc

ctgg

cact

tctg

caat

gagt

actg

tgga

gcct

gacc

tttgg

ctag

tagc

ttggt

cttta

ttgac

aggg

ctgt

c

1179

2428

310

NO

cccg

ggtc

tgtc

ataa

ccgc

aaat

ttcta

tacc

actc

tgct

gcttt

aaga

tatc

aaca

ggca

aaag

ataa

ccac

tgtc

caac

tcac

ataa

aaat

agga

catc

aagt

tttgg

ggga

cttc

atgt

ccta

cctc

cagc

ttact

aagc

ctgc

tatc

tctg

gaga

ttcca

ctac

tgca

aacc

tagt

tagg

caat

gggt

aata

gcat

tacc

catta

agcc

aaat

gtgg

agtg

aaca

ataa

taat

aatc

acta

ggac

ttgga

gagt

cact

aaat

aaag

atttg

ttgag

taag

tgga

ggaa

ggct

gcct

tcta

agct

gtgt

atca

ctttg

gccc

caac

ctgc

agta

ctcc

ttccc

actg

tagc

cact

gact

cctg

ctcc

cagc

ttcaa

aggc

tagg

atcc

tctc

ataa

agaa

ttacc

aaag

ccag

agat

ccct

acct

gcct

aata

tata

ctga

tgcc

tcat

gtgg

gccc

ttga

1180

2429

289

—N

Otg

tggt

ttgat

tagt

aact

accc

tgga

gtgt

ctca

acttt

1181

3246

430

—N

Oac

ccga

tgttg

acag

tttct

ccct

ccct

ctct

ctct

ctgc

tgttt

cctc

tata

gagc

taag

tctg

gtttg

cattg

aaat

aagc

atgc

agta

atat

gcct

tttgc

ctta

cca

acttg

tattt

gcac

acag

gcag

ca

1182

3314

235

NO

gtgt

ccta

agcg

ggtg

catg

tcca

g11

8323

3284

1E

RM

AP

YE

Stg

gaga

agag

cccg

gttg

cattt

tg11

8424

5207

7PI

K3C

2Y

ES

catg

gtga

tgca

tattc

gggg

cttg

B

1185

2592323

NO

atag

aggg

ttcttg

cagc

tgtc

caag

gtag

aggc

agtg

gaag

cttg

cgct

cagt

agaa

tcag

tgga

ggta

ggaa

gagg

tgga

caga

ttcag

gtta

tgct

ttgg

atgt

gata

ccaa

tata

gaag

gatc

ctta

tgttg

aagg

atta

gatg

cagg

agtg

agag

caga

aagt

caag

gatg

gctc

taca

gcag

ctac

taga

accc

ctt

gaaa

aatg

gtaa

tgct

gtac

acgg

agct

ggga

aggc

aagg

aggg

ggca

gggg

cagg

agttt

tgta

ggac

tcaa

tagg

tttgt

ggag

agaa

aagg

aggc

tgat

ggga

aaat

caag

ggct

ttgttt

tgag

caac

atca

agat

acct

atta

aata

ttcaa

ggca

tcaa

acag

taaa

tgag

tcag

agttg

tact

agta

tcaa

gattt

ttg

atca

ttgttt

tatta

atcc

taat

acaa

acct

tcct

agttg

tcag

ggttc

agc

1186

2895598

NO

atgt

tctc

ggaa

caag

gaac

cagt

aaag

taca

gaca

tctg

gccc

cagg

atttt

gctg

gctc

cagg

gacg

tcac

tata

aacc

cact

aaca

ctaa

ttgct

ttcac

gtct

gctc

ccat

ttcta

1187

3578431

NO

catg

cgaa

agca

acag

tctg

atct

ccag

gtta

tgaa

aact

ataa

ttaaa

aagt

cact

acac

agaa

aagg

tcca

agttt

ccag

cttg

gcaa

aact

tggg

tgca

gtta

catg

aaac

gttta

ataa

actg

aattg

ttttc

ccca

atgt

gtaa

acaa

aatg

acaa

gact

aaat

ctgt

gcct

ggta

atttc

aatc

taac

tctg

aagc

taca

caaa

acac

acag

acac

cttg

taca

tttca

cctg

ttagt

atga

ccat

ctttt

ttcttc

ggtg

gtgg

aagg

aagg

gcaa

ggtg

actg

tgta

aagc

aaag

atgt

ggga

agt

agaa

atat

tgttt

acta

gaca

ttata

aagt

catg

gtga

aaag

aaag

cttc

gatta

atgc

atag

ccta

aggg

1188

3590373

NO

tcttg

tggt

tcct

taac

ttgtg

gcag

cata

actc

cagt

cttc

acat

gaag

ttcttc

ctgt

gtgt

gtat

ctga

gtcc

taat

ataa

ggag

acta

gtca

tattg

gattg

gggt

ccat

cctg

ctct

gtta

atga

cctc

atct

tagc

tgct

gaca

tctg

taat

gact

ctat

tacc

aaat

aagg

tcac

agta

tgag

gtag

tagg

ggct

agga

ctttt

aac

atac

gaat

attg

ggag

gaca

cagt

tc

tgcc

tgct

tcac

acaa

gtcg

aact

gcaa

ctgg

gatc

ttggc

ttcttg

tcaa

gtca

gtag

catg

caag

ccag

tttaa

gtca

aaag

agga

caca

ctcc

tctta

ctt

(Jl

1189

3277334

NO

gattc

ccct

tgcc

atct

atttt

ctcc

ctca

atct

tagc

cact

tgga

gaag

aattt

aata

ccttt

tttttt

tcca

gagt

ccaa

aggc

tgtg

gatc

taag

tggg

gcat

tttg

tgct

caag

cgaa

tctg

ccat

gcac

tacg

gtttc

aact

c

1190

2323027

...

NO

gagc

ggta

tcttg

aagg

tggc

tttaa

gtttg

ggaa

gttc

ggga

agag

cagt

aaag

gcac

gata

ctgg

gact

gagc

ccag

tagg

agt

1191

2360843

HCN3

NO

tgtc

agca

gatg

tcttg

ggtc

ctga

gt1192

2834307

STK32

YES

gaat

aaac

aaaa

gtgc

gtgg

agcg

caat

gaag

A1193

2890310

C5orf45

YES

aaga

agaa

aacg

tggg

acac

cagc

aggc

1194

2510000

—.

NO

gata

atga

agcc

aacg

caaa

aatc

cacg

tctc

cagg

ctaa

1195

2575065

NO

tcttt

ccag

ctca

tgtc

tccc

gggg

ggct

gggc

tgtc

tcct

gtcc

tgca

gccg

cagc

acttg

atct

cagc

aggt

ggaa

tgca

gagc

agag

gaat

ccgc

cag

acat

taca

ggga

tcta

tctg

agta

taaa

acgg

gact

gctc

tttcc

acta

aattg

ctttt

ggag

aata

aagt

taag

tgaa

ttaaa

atttc

ccca

gtct

caat

tgct

aat

atgg

taaa

tattc

gcag

ttaca

actc

tcat

taac

aaaa

tctc

ttagg

agtc

ctca

gtaa

tttga

gact

gtaa

agac

gtct

tgat

acta

caat

gcct

gaga

acga

gttc

tctg

gatc

ttacc

tgcc

cctc

ttaca

tgag

gagg

cacc

ctga

tgtc

tggg

tggc

ttacc

ctttg

gcct

ctgg

cggg

cattc

agca

tgag

tgaa

1196

3336

723

FBX

LIl

YE

Sttt

aatg

taga

gtat

attc

agcg

gggt

ggct

tgag

agat

cctc

tgat

tttca

agaa

ttctg

atgg

actc

ggaa

taaa

1197

3660

063

—N

Oca

tgct

ctga

cgct

ctat

gcca

ctgc

tgca

cct

1198

4029

263

—N

Ota

aaag

actg

aaca

agaa

gggc

acag

tgttc

acgg

agat

tgaa

gtga

acaa

gaaa

1199

2663789

CHCHD

NO

gatg

aaga

tttgg

accc

ttcca

ttcat

aatc

ccttt

ctaa

gtga

aggg

agag

gctg

gcttg

gctg

ttcct

tgtta

ttccg

aaag

ccct

ggttt

gggg

ccca

tgttc

4ac

actg

gctc

tcag

tcta

gtca

ggtg

ca

1200

3743045

___

NO

gcca

ctct

cgtg

ctgc

ttgag

ctgc

1201

2826559

NO

agca

aaga

ctct

cggg

aaca

ccct

atta

cagg

aaaa

tctc

tcat

acct

gacc

tctg

ctta

accc

actc

gtga

gatta

aatg

atag

tcttc

attc

tctc

tgta

gaat

ttgct

gact

gatg

ctca

tgct

acat

tgaa

tgac

agta

gact

attc

tttag

tttta

tcttg

aact

tttat

tccc

ccca

gtta

ctgt

agac

ttacc

aaga

aaca

tttgt

gttt

gtac

ccaa

caca

ctgt

tatg

gcac

ttgat

gttg

taat

caca

tagt

ttaat

gaat

tatta

ttcag

tgaa

ctct

gaag

ataa

aaag

gcgt

ttgta

tgag

aacc

aattg

gct

acttt

gaaa

tcaa

gtga

gtag

ccaa

aatc

aatta

tggt

tgaa

atag

atga

gggt

taaa

taat

tttaa

atga

ttagg

gaaa

aaaa

aaca

aaaa

acac

ctaa

cgat

ctaa

aaaa

atct

gcaa

taat

atta

tttttc

acgt

ttgta

aaat

gtct

ttctg

tgttt

aaga

aaca

gaaa

ctgg

aaat

caca

ggtg

ttgttt

tatg

gggg

tagt

ttttg

caag

aaaa

agga

aata

gaac

tttct

tcga

taga

ccca

cact

gga

1202

2882611

FAMIl

YES

gtga

gcca

gcca

agaa

ttctg

agtc

tgttg

acca

aggt

gcca

aacc

agag

agta

aatc

agaa

cctg

tagt

ttcca

ctcg

gaa

4A2

1203

3044784

—NO

gacc

cacg

gcaa

ttttg

aata

cttg

gaag

agca

gtct

aagt

accc

tcac

acaa

1204

4016017

ZMATl

NO

tgta

ggta

ttccc

atgg

tttca

tcct

tgac

ctta

ctct

acaa

acac

gattt

ctat

ttccc

tgat

ttcat

ttctc

atct

gtat

gctta

tgac

ctttc

tgtc

aagt

atta

gattc

acat

atcc

aaat

ggca

gcta

ctgc

ttcac

ctgg

atgc

ctca

tagc

caU

l1205

2872559

—NO

ttggt

gatg

cttta

tcga

cctc

tgag

aatc

ccttt

gtga

tctg

cagt

gcta

ctgt

ggttc

acaa

aatc

tgtg

ttcttg

ctct

ccct

gata

gcat

ctga

cattt

gtca

tcag

gggt

tggc

aatc

1206

2810393

MAP3K

YES

tgct

agtg

caac

tact

gctc

catc

gatc

ccttc

acat

ttgtc

tcct

ggttt

acga

gatg

tggc

tcttc

gttg

tttag

aact

tc1

1207

3309863

NO

aagt

gtag

cggc

aggc

atcc

tggg

a1208

3349873

NNMT

NO

gaat

gctg

ttagc

ctga

gact

cagg

aaga

caac

ttctg

cagg

gtca

ctcc

ctgg

cttc

tgga

ggaa

agag

aagg

aggg

cagt

gctc

cagt

ggta

caga

ag

tg1209

3849058

NO

gtac

atca

ttacc

cggc

acag

acac

a1210

2609601

—NO

cccc

tcaa

atct

taca

gctg

ctca

ctc

1211

3489275

NO

tctc

ttgat

tagt

ctag

gtgg

tggt

ttagt

tctg

ttctg

atttt

ttattt

gtttt

agag

atgg

catc

ttgcg

atgt

tgcc

taag

ctgg

actc

aaac

tcct

gggc

tcaa

gtga

tcct

ccca

cgtc

agcc

tccc

aagt

acct

ggga

ctgt

aggt

gtgc

acca

ctgc

acct

ggct

gtct

gctc

tgat

ctgc

acca

ctgc

acct

ggct

gtct

gctc

tga

tcttt

atta

tttct

tcca

ctaa

ttttg

gattt

ggttt

gttc

ttgct

tttgt

agttc

ttgag

atgt

gcat

tgct

agat

tgttt

att

1212

3490771

NO

tctc

cgta

ttgct

tagg

gtgg

tctc

gaac

ttctg

acct

caag

cagt

ccttc

ggcc

ttggc

ttcct

gaag

tgct

agag

ttaca

ggcg

tgag

ccac

agca

cctg

gcct

acat

atta

cattt

aagt

ctgt

gatg

cattt

tgaa

ttttta

tgtc

aagt

gtga

gattt

aact

tgag

gttc

ctttt

tgtg

gggt

ggat

agta

tgttc

gggt

gttc

tggc

acct

atct

tttct

cattg

aattg

ctttt

gcac

ctttc

ttaaa

aatc

agttg

agcg

tattt

gtgt

gagt

ctat

ttcta

agttc

ccca

ctgt

gtta

gattg

agct

gtat

gtga

tcta

tatg

tatg

ttcct

ctgt

cagt

ccca

ctgt

ctta

agct

gtag

ctgt

ttaag

tctg

aaat

tggg

caga

ctca

ttcct

ccta

cttta

1213

2353

513

NO

taat

gtca

tcat

cagt

gggc

aagt

ctag

aacc

ctaa

tatc

ctgg

tgct

caaa

atta

gtgt

tatc

aattc

agtc

ttctc

caca

ttaaa

caat

ttcca

attc

ctttg

agg

cctg

gtgt

gatg

gattc

tgtc

tttca

aatg

ctttt

tttct

ttcag

tgac

tcta

tcgt

tcat

aaat

gtta

aata

aaac

cctc

actc

tgtta

taaa

aata

taga

cttta

aaaa

tttt

ccaa

agta

aaca

ctcc

agag

aaag

gtag

gcgg

gctg

aata

ggct

gctg

ttgtc

cttc

ttact

gccc

a

1214

2610

157

CR

EL

DY

ES

catc

tgtg

tgaa

ggag

caga

tccc

a1

1215

3092

298

LE

PRO

YE

Stg

ggga

gcttg

tgca

cttg

ttctc

acag

gaaa

caca

gtca

tcttt

gcaa

ctat

acta

ggct

ttttc

ttggt

ctttg

gaag

caat

gacg

acttc

agct

ggca

gcag

tT

Ll

1216

3241

630

CC

DC

7Y

ES

taaa

gaaa

atcg

acca

gaag

cagt

gaaa

agttg

1217

3489

976

NO

ctct

gagg

tttag

gcct

cgat

attc

agga

gagt

ggtg

tagg

agga

agat

gaac

cact

gggt

tttag

acac

atgg

aggc

ttagt

tcag

ggct

ttggg

cctc

ccgg

ttagt

ttgttt

agtc

ttgttg

atct

agga

ggag

atca

cacc

agat

ga

1218

3671

050

PLC

G2

NO

ggag

aacg

tgcc

ctat

tcac

actc

tggg

aaga

cgct

aatc

tgtg

acat

ctttt

cttc

aagc

ctgc

catc

aagg

acat

ttctta

agac

ccaa

ctgg

catg

agttg

gggt

aattt

cc

1219

2476

149

—N

Ogt

cagt

taga

caga

gtcc

acaa

ggga

gtcg

1220

2670

672

—N

Oga

actc

acgg

tcttc

agcc

ttcct

gc12

2127

9284

8—

NO

tggc

catg

gtga

aaca

gtgc

ctct

a12

2231

6812

7—

NO

ttcca

atca

gcag

tatc

atgg

atta

aat

1223

3227

785

—N

Ogg

gcag

tttga

ctat

gtcg

catc

cagc

ttccc

atgc

cgtc

catc

ccta

ggag

tctg

tctc

acca

taca

aggg

cgca

gaca

ggcc

agct

tgag

ggtg

ttcat

caa

cgca

gcat

tgttt

gaag

agca

gaag

ttaga

atct

attc

attc

gggg

gcct

gact

gcat

aaat

acac

tgtg

gttg

ccgt

ccag

ca

1224

3367

153

—N

Oct

tgta

tgac

ccttt

gtct

cggt

tgac

tagt

tgttt

gctc

taag

aata

tttca

tgttt

tgct

gtttc

tttca

gtttg

tagg

tgct

aagc

tattg

aaag

gttta

gaga

ctaa

tct

aggt

ctttc

taaa

ttatg

gctg

cttg

cagt

tttat

tcct

ggag

aaat

ggttt

aaca

gcac

ttcttt

gagt

tggc

actc

ttctg

cctg

tctc

agct

ctaa

ctttc

ccgc

ctcc

ttctc

agta

gtcc

ctct

ttcac

cctc

cact

cccc

aagc

ctga

aatg

gaaa

gaac

ttgct

ttgtta

ctga

tgat

aata

tttaa

gctc

taaa

atttt

aaca

gtgt

ttca

gttg

caaa

taaa

tgga

aattg

tgta

ttctg

tttaa

tgtg

tttca

gaaa

atcc

ctgc

tattt

tttttt

tcttt

aaat

acaa

gaaa

acag

gcgt

gtaa

tgcc

tcat

tgaa

aa

1225

3483

227

—N

Ottt

agtc

aagt

aggt

tgag

agca

ccag

ggat

cattt

tttct

tcaa

ccttt

tagc

tcag

tgat

accc

agag

caat

gtgc

ctac

tcag

tgga

gaag

atag

tattt

gtgt

gaat

aaat

ttact

gttc

tgtg

tgtta

catg

tcta

gtta

ggag

tggt

cctc

taat

tctg

ta

1226

3766

878

POL

G2

YE

Saa

aatg

tggt

tcct

tgtg

ttctc

tctg

taaa

tggg

gacc

taga

ccga

ggca

tgct

ggcc

tacc

tcta

tgat

tcttt

ccag

ctg

1227

2555

150

NO

tggg

cgtg

aata

agga

agca

aaac

tcaa

ttata

ataa

catta

ctat

tgttc

aaac

ttcac

atgg

cact

tgca

accg

gagg

ctac

tttgt

ctgc

ctgt

ctcc

atac

tca

tgct

gtct

tatg

ctca

tgttc

ttca

1228

2601

747

DO

CK

lY

ES

gata

ccac

ttccc

actc

gtct

tcca

aggg

gggt

ggag

gagc

ggga

ggaa

ctgg

tgttt

tcaa

gtcc

ggct

ggct

ctac

aagg

ggaa

tttta

acag

cacc

gt0

gaac

a

1229

2664745

—NO

ttatc

cacc

gcac

atga

aaga

gagc

tcag

cgcc

aact

gcca

gtcc

actg

aagg

gtgt

cgca

gtga

tattt

gtttg

a1230

2698409

—NO

atgt

gcta

ctaa

cagg

tcag

gagc

ccag

atca

aaga

gctg

gtttg

ggag

gtgg

ataa

tgaa

ggttg

tgaa

gtct

gtgc

tccc

tctg

agaa

gcct

gagg

aaa

atgc

aggt

ggct

ccct

caat

caac

agac

atcc

aaaa

tgg

1231

2704917

PHC3

YES

atca

gcag

attc

ctct

tcat

tcac

cacc

ttcca

aagt

ttccc

atca

tcag

ctga

tatta

caac

ag1232

2823922

CAMK4

YES

aaat

ggga

ttgtc

catc

gtga

tctc

aaac

caga

gaat

c1233

3717013

___

NO

ggtc

tata

tgtc

tgta

ctta

tgct

ggta

ccac

1234

3498270

___

NO

atgt

ccag

cgca

agga

cact

gtcc

agcc

ttctc

ttcct

gcac

atca

gctg

cctc

ccgt

cagt

cctg

ctga

acgg

ggat

ccttc

ccag

atttc

1235

3737381

—NO

cttc

aaag

ggtg

tcca

gatg

ctat

gaag

cattg

ggttc

gact

tggg

gtcc

acgt

ggttt

gtgc

ctca

gggt

ccaa

aacc

acct

gcat

tcta

ccgg

tggc

gtct

gcag

aaga

cgaa

tggc

ttgaa

ggag

ctgg

cact

ccgc

cggc

taga

tgat

ccaa

acca

tttca

tttct

ttgtc

gtgt

ggaa

aagg

ccct

ctgt

gatg

cact

tct

gttc

tctg

ga

1236

2512319

LOC643

NO

ctgt

agct

ttgag

tttgc

accg

ttcct

tgtc

ccag

gaaa

aagt

taag

aaac

ttaaa

atgt

tttgt

tttgc

tttta

aaga

agac

agga

caga

aaac

ggga

tttaa

aa072

ctta

gtttt

taaa

aaaa

caaa

agct

acag

agta

ggga

gcat

aggt

caac

catc

tcca

ccta

aattt

tttttg

ttcct

aaac

tcag

aattc

taca

accc

aact

aaat

taa

tatg

ccaa

gattt

tgcg

gatg

ttaaa

actc

aaaa

aaag

cagt

atgc

aaga

cggt

cccg

gggt

aaaa

ttcta

ctgc

ctttc

cacg

gaca

agtta

1237

3596425

NO

agtc

ctcg

ctgt

agca

tggg

gtaa

agcc

agga

tatg

acttc

acat

agttt

aact

ccag

aact

taca

ctgt

catc

ttgttt

tgttt

ttctg

cttc

tcttg

tgtg

tcaa

aaga

attc

ctcc

ttagt

tgttc

tcat

atgg

ggca

acca

ttaaa

ttagg

cagt

gtaa

aaaa

caag

ttatg

caga

ataa

agta

gcaa

gagc

aatc

tact

ctga

aatta

gtg

ttttc

cctc

acttt

agca

ccttt

agct

gacc

cagc

ttcct

accg

ccca

gaca

tttta

caaa

aatc

tctc

tctg

gagt

tgcc

tcct

gatc

tgga

ttagg

agtc

acat

a

1238

3809494

NO

ctgt

gttta

acac

ggct

gtgc

tact

tcag

gctc

ccat

ctcg

ctga

gggt

gccc

atgt

cagc

caat

gacc

tt1239

2442446

NO

gtct

tttgc

agta

ggtc

aggg

ctaa

gagg

acta

atcc

ctca

agag

tgaa

gaaa

aaaa

ctat

tgat

ggtg

gcttg

aaag

agtc

aact

gctg

tagc

ttttc

ttgga

gatg

atca

caaa

atgg

ggag

caga

aaac

aggt

tgaa

atta

caga

agat

taat

tagt

aaga

aaag

atgg

gtta

aaga

tgta

aatta

gagg

caaa

gtta

agaa

gaat

ttggt

ttcttc

atta

tact

caga

aagg

taag

gatg

gaaa

agttg

atgg

agca

agat

tgtg

aagt

atct

tata

tgca

agac

taag

aagt

ttgga

ctag

attc

tga

agac

ttagg

agaa

ccag

tgaa

gaaa

tctta

atag

agga

atcg

gatta

gatc

ttagg

gtca

gaac

aatta

ttagc

aagc

aggg

tagg

tgaa

gttc

ctgt

tgac

ccac

tttg

1240

3281111

—NO

agca

tctg

tcgc

tggt

gaga

ccct

cagg

aagc

ttcta

ctca

tgttg

gaag

gcag

tagg

gagc

tggc

atgg

cttg

gcga

gagg

caag

gaag

gaga

gggg

aag

gctc

ttttc

cata

agca

gttc

tccc

tatg

gcac

caag

ccat

ttatg

aggg

accc

accc

ccat

gacc

cagt

cacc

tccc

accg

agca

ccac

ctcc

aaca

ttggg

gatc

acat

tgca

acat

gagg

tttag

aggg

gaca

aata

ttcaa

actg

tatc

actg

ggag

atgg

ggct

accg

gaag

tcaa

gcca

ttcc

1241

3770080

—NO

ctgt

acta

agtg

ctga

tgtg

ccag

cgct

atg

1242

3821078

—NO

acag

atgt

gatc

aaaa

ggcc

taat

atat

gtgt

aattg

gagt

ccca

ggag

tgaa

gagt

gaaa

atga

ggca

gaaa

aaaa

ttcaa

gtga

gaat

ggct

aaga

attt

cccc

aaac

tgat

gaaa

ggca

tcca

ccca

caaa

tccc

aattt

tgta

cttc

caac

cact

gtta

tacc

accc

ccct

caac

aatg

ccta

taaa

tgttt

gttg

aaaa

tga

gtga

atga

atgt

actc

caat

cattt

tctc

acttg

gatg

ttccc

tact

ttttg

c

1243

2531265

SP140

YYEE

Sat

aata

gcaa

agcc

gacg

gcca

ggtg

gtct

ccag

tgaa

aaga

aggc

gaac

gtga

atct

gaaa

gacc

tt1244

2719554

CC2D2

YYEE

Sac

tggt

ggct

cgat

atgt

gtcc

ttgat

tccc

ttcttg

cctg

acac

tgtc

tcat

ttggt

ggta

tctg

tA

1245

3342924

—NO

tgag

gtcc

acaa

atca

gtca

agttg

aata

aaga

ggaa

attc

taag

gaaa

atat

taaa

aatta

caga

aaga

ggaa

gctg

ggga

cact

gagc

ataa

acttt

gat

gaca

tcaa

tttta

ccgt

gtgc

ctat

ccac

tattc

ctcc

actta

gtttc

tcag

atct

tgcc

agca

acct

tagg

gcttg

catc

ctcc

atttc

1246

3811421

NO

gtac

gtgt

gagt

gcgc

tgta

taaa

gtct

ggaa

ccac

aatta

g1247

2448106

___

NO

ttgtg

tgat

tgca

atgc

tgaa

tttgt

c1248

2661177

___

NO

ccttg

ttccc

acat

cggc

acat

tatc

1249

2748212

NO

aggc

atttt

ttgtc

caca

cact

tgct

ttggg

gattt

ttatta

ggta

gacg

gtaa

ttaga

ggtg

tcag

tcat

atga

aagt

aaat

cact

agtc

tttcg

tatta

ctgt

tttct

cagt

ggtc

ctta

tcag

tttttt

ttgttg

ctct

gtaa

tcat

tcat

atgg

taag

actta

acttt

tagt

catg

taaa

tttgt

ttagg

gaca

attta

aact

atttt

gtca

aatta

gtc

gtttt

attc

caag

ttgta

cgtc

ttatg

cattt

attta

gtat

agtg

aaag

cctta

tata

caca

tttaa

tata

atta

gtct

ctgg

atat

ttgga

ttattt

tttag

tagt

acttt

ttta

gagt

gtgg

gtttt

ttcttt

tcttt

tctg

tttttg

agac

agtg

tctg

gttc

tgtc

accc

aggc

tgga

gttc

ggta

gccc

agtc

tt

1250

3081649

NO

cacc

tttgt

gcat

gtat

atac

ttcaa

gttg

tatg

aattt

cttta

tgca

aaga

gcct

ttaaa

atat

aaac

tgtg

atttt

tgttt

ctaa

tttttt

acttt

ggat

tgac

aggg

cct

tttttc

aagt

gttg

gaat

ttcct

tttag

atttc

ttatc

agag

tttat

cttg

atttt

actg

aaat

tcat

ttagc

tata

tgaa

attc

cttta

gcca

tagt

cttg

attc

agat

cccc

ccac

ctga

gtct

ttcca

ggac

cttg

tgcc

atct

gtta

ttgcc

attg

ttgta

ttcac

ttaca

gcct

cttc

tcca

tgag

taca

agcc

cacc

atca

tgct

c

1251

3415065

NO

gagc

cattc

ctttg

gcaa

ctct

tgct

gtca

gcca

tcttc

caaa

gagc

tttg

1252

3436225

NO

tgtc

tacc

atgt

tggg

cagc

acag

atct

aaag

cattt

agaa

ccat

ggct

agag

ctat

gtgt

ttact

atca

ttgct

tcaa

tatg

gaga

gtca

tcca

aaca

ggttt

cattt

gctc

ccag

ataa

actg

tcat

ggga

cctg

ccgt

ggcc

agtg

ctca

ccttg

tact

gctg

gaat

aattt

aaca

atttt

tttca

actg

ccat

catc

atca

tgcc

atttt

atgt

cttc

gtag

cattt

atca

ctat

ctaa

aggt

aggt

cgct

ta

1253

2546677

—N

Oct

ccca

aact

cttg

agga

catg

tggg

gaac

taca

gctg

g1254

2723423

___

NO

aagg

tagt

gtgc

aaag

cgaa

aaga

gggc

acag

acca

aaat

catg

caaa

a1255

3291647

___

NO

gtgg

gtta

catg

ttcct

gcct

ggca

1256

3449366

IPO8

YE

Sgg

acct

caac

cgga

tcat

ccag

gcgc

tgaa

gggc

acca

tcga

cccg

aagt

tgcg

gattg

cagc

cgag

aacg

agct

caac

cag

1257

2935290

___

NO

gtttt

acaa

cacc

caaa

gcaa

caga

aa1258

3296065

KCNM

YE

Sgt

tatg

gtga

tctg

ttctg

caaa

gctc

tgaa

aaca

tata

atat

gcttt

gtttt

ggaa

tttac

cggc

tgag

agat

gctc

acAl

1259

3414403

SMARC

YE

Sta

cggt

gtac

tgtc

ctac

tgat

gctg

gatta

cca

Dl

1260

3611215

___

NO

ctag

tcta

ggga

tagt

ggta

gaag

tacg

taat

gtag

atg

1261

2997513

___

NO

ccttt

gctc

tctc

atat

gcat

ccgg

caca

gcag

c1262

3180413

NO

ttcaa

gggc

atag

gcgt

cgga

attg

tgat

ttcgt

gcgt

gttt

1263

3732

510

—N

Oga

acca

ctttg

ttgac

cttc

tgct

gcaa

1264

2572

597

CC

DC

9N

Oct

ggac

ggtg

tcta

tcaa

aagt

gcaa

atgc

ataa

gctc

tttga

acta

gcaa

tgct

actc

ctaa

gaat

tgta

cctg

tgta

caag

gtac

ttgtg

taca

agag

tttttg

t3

tgaa

acat

tgta

atag

caaa

aagt

tgga

gagt

gcca

ccaa

taca

gggg

aatg

gtta

aata

catta

tggc

cagc

ttaaa

caat

ggaa

tagt

ttgta

gaaa

tttaa

aaca

atgg

atcc

tgtg

tgtg

tgta

ctac

cata

gaat

gggc

ccca

agat

gcat

gatta

agtg

agga

aaaa

agcc

catg

gtat

ccta

atgt

ttgga

atgg

agaa

agt

gtgt

agat

gtat

gtgt

gtgc

atat

gtttt

caca

caga

cgta

taca

cgtg

tata

tcat

atgt

ccac

ctgc

atat

gcct

agga

tgtc

tctg

ggag

gata

tcta

gca

gccc

ggca

gcct

gaat

tgcc

tctg

ggaa

1265

3216

409

—N

Oag

gttc

tgaa

gtcc

cagg

caaa

tgta

atag

gggg

tagg

caga

ggac

ttact

taga

gaga

tggt

ggtg

aaag

tctc

aaac

tgca

gattt

ctag

aaca

aaca

ggt

tact

tgta

agaa

gcag

acag

agat

actta

gatc

agta

aaat

acttc

tgta

acac

taga

agtg

agaa

gaca

tgag

aacg

ttatc

taga

aact

atca

agag

gaaa

tgac

tgca

gacc

aaaa

atcc

tacg

c

1266

3294

290

—N

Otc

caca

gctc

gattt

ggcc

aattt

cgag

ttgaa

agga

tggt

actg

gacc

cagg

cctc

ataa

gtag

cttg

tcat

caag

atct

ctag

tagc

caaa

tcag

aaac

ccac

aatg

aagt

aaag

atca

gtat

gtca

agga

agac

aaga

ctaa

cggg

gtaa

aaag

cctta

gact

agaa

acta

cattt

aggg

ggaa

ataa

agca

aaaa

taaa

aacc

tttca

ataa

gtaa

cact

agttt

ccag

atgg

tact

ctag

ctca

ggca

tgag

aatc

tgttc

ttaaa

agtg

ggac

atta

tttca

atca

taaa

cata

attta

ctag

aat

ggac

atttg

gcaa

agca

agtc

catta

tcca

cctg

ccat

caca

gtca

ctttt

ttagt

cacc

agtg

aagg

caag

cctg

aagg

acac

ctac

tcca

aagt

gcttc

cca

aaaa

tttgc

caca

gggg

ctga

ttcct

actc

tgttt

gagg

cattc

ttttg

tgct

gaaa

gattg

tcac

caga

aaga

caac

tgaa

agac

aaat

attg

ctgc

ttggg

agca

gttg

tggc

acca

gtgt

ggct

ccca

ctgt

agca

atta

aag

OO

1267

3446505

—NO

gtct

tgta

gcac

tcaa

acct

ttgtc

tttcc

caca

agac

tgaa

aact

ccat

gaca

cagg

aata

tttct

tatc

ctgt

gaac

ctttg

tgtc

atac

cacc

tata

gtag

tgttt

agta

taaa

ataa

atta

attg

tttgg

aaat

ctat

ccta

aaaa

aaaa

aacc

taga

ttcag

taaa

agct

ctgt

ggcc

aagg

atgt

ttgtg

ttaca

gtga

acac

cttc

gagc

acttc

agg

1268

3616936

NO

ctca

tagc

atgg

tggt

ctcg

cagt

agtta

gcct

tctta

cata

gtta

ctgg

cttt

1269

3628351

MGC15

NO

cctc

cgtta

cccg

tcag

ccca

gcat

ccgg

ctttg

cttc

cata

a885

1270

2745112

—NO

gcaa

aattg

gtct

ggta

tctg

tcta

aattg

gtca

atac

aagt

gtta

ttctg

gaat

catg

taaa

aatc

actta

ctttc

ataa

ctgt

ttaga

accc

caaa

tgttt

tccc

tttga

aggg

gaac

atct

gtgg

aata

tgat

tttga

atag

agga

cttc

tatg

aaat

atat

ttcaa

atct

taaa

aata

ttttta

atac

ttcct

aaag

tggt

atag

gattt

accc

tcg

ctga

ctat

gcct

tcca

tttaa

gaac

agtc

ttgca

tttgt

ggct

tttca

1271

2824232

APC

YES

tgtc

cctc

cgttc

ttatg

gaag

ccgg

gaag

gatc

tgta

tcaa

gccg

ttctg

gaga

gtgc

agtc

ctgt

tcct

atgg

gttc

1272

3101817

SGK3

YES

agttc

tggt

ttcag

tggg

aaga

agtg

1273

3129414

NO

ccta

gctg

tctg

tcag

gtag

aatg

aggg

tgaa

ggag

atct

agga

tgct

tcag

gcat

tgcg

cttg

aact

taaa

aaac

agga

tcag

cagg

ccct

gact

tcat

aagg

ccca

taaa

taca

aatg

acta

gctc

ccttt

ctca

aggt

cattg

aaaa

tata

cagt

agttt

caga

catc

acat

gggt

ttggg

caaa

gggg

gcag

atttc

caag

cta

ggtc

actta

atgg

tatc

1274

3576514

—YES

gtgg

ccgg

gagg

caaa

acttc

tcta

tgag

tgga

aacg

tttga

agaa

taca

tcac

ccat

tacg

atttt

gcta

atct

tagg

tttca

gaca

ccac

agac

acat

tgat

tct

atttg

gaaa

gata

gcca

tcaa

tcag

ccag

c

1275

3650814

COQ7

YES

ataa

agaa

atttc

ggga

tgaa

gagc

ttgag

cacc

atga

cata

ggcc

tcga

ccat

gatg

caga

attg

1276

3723777

—NO

gcca

aaga

gcat

gtag

agca

aact

aggc

tcta

ttcag

cattt

ccat

ttctta

atgt

atct

atttg

atttc

aata

aaat

ttcat

cattt

tgaa

gatc

tctc

ccat

tagc

ttgg

gaaa

ctac

agaa

acat

gcac

ataa

ctac

tgag

aagg

tatc

aagt

gttc

ctac

acta

gttta

aaaa

aatc

attc

aaca

ccca

cata

aattc

tgat

atgc

acta

ggct

gaac

agct

gtta

acca

ctga

gaag

ctgg

gcac

tgca

tcct

ctcc

ctgg

gtca

aaac

tcta

tatg

ct

1277

2550931

NO

atgc

acat

ggga

cagt

ctaa

gatg

gtag

tggt

gg1278

2681842

___

NO

acca

agtg

acat

tttgc

attc

agcc

tt1279

2868846

___

NO

gctc

tagt

gcca

cagg

aagc

tgcc

t1280

2880139

PPP2R2

NO

agcc

aagg

gaga

accc

aaga

caga

gaa

B12

8133

0907

3—

NO

attg

aatg

attg

tttag

aggc

agtg

tga

1282

3636

536

HD

GFR

YE

Sgc

aattc

agca

acag

agct

cttc

agaa

P3

1283

2347802

RWDD3

NO

ggga

taca

ttcag

gtct

cagt

tgttg

aggc

tgttg

agca

gcaa

tcca

ggta

tgaa

aatg

ggaa

agat

ttgac

tgct

tctc

tcat

gcag

ggga

ataa

agca

aag

gc1284

3202177

PLAA

YE

Stc

ctgc

acttg

acat

tcttc

ggttg

tcaa

ttaaa

cacc

ccag

tgtg

aatg

agaa

cttc

tgca

atga

aaag

gaag

gggc

tcag

ttcag

cagt

catc

ttatc

aatc

ttct

gaac

ccta

aagg

aaag

ccag

caaa

ccag

ctgc

ttgct

ctca

ggac

tttttg

caat

tgttt

tgttg

gcca

ggca

ggac

aaaa

actc

atga

tgtc

ccag

aggg

aatc

actg

atgt

ccca

tgca

atag

aact

ga

1285

3945822

—N

Oaa

ggaa

gcga

gaga

cttg

gcag

tcct

gtag

gcttt

aatg

gaat

cagc

aatg

gacg

ctcg

1286

2682207

—N

Ogg

ggct

ttaat

tctta

atcg

ctgt

gagg

attg

ttatc

cgtg

ggat

gtga

gctg

tctta

gtgg

tattc

aatc

aagt

gtcc

actta

gcca

tgac

tgga

agta

attg

ctc

ccaa

gtgg

gcc

1287

3263773

DUSP5

NO

agcc

atta

cggg

agca

cagc

atgt

gctg

acta

ctgt

acttc

caga

cccc

tgcc

ctct

tggg

actg

ccca

gtcc

ttgca

cctc

agag

ttcgc

ctttt

cattt

caa

gcat

aagg

caat

aaat

acct

gcag

caac

gtgg

gaga

aaga

agttg

ctgg

acca

ggag

aaaa

ggca

gtta

tgaa

gcca

attc

atttt

gaag

gaag

caca

atttc

cacc

ttattt

tttga

acttt

ggca

gtttc

aatg

tctg

tctc

tgttg

cttc

gggg

cata

agct

gatc

accg

tcta

gttg

ggaa

agta

accc

taca

gggt

ttgta

ggga

catg

atca

gcat

cctg

atttg

aacc

ctga

aatg

ttgtg

taga

cacc

ctct

tggg

tcca

atga

ggta

gttg

gttg

aagt

agca

agat

gttg

gcttt

tctg

gattt

tttt

tgcc

atgg

gttc

ttcac

tgac

cttg

gact

ttggc

atga

ttctta

gtca

tact

tgaa

cttg

tctc

attc

cacc

tcttc

tcag

agca

actc

ttcct

ttggg

aaaa

gagt

tcttc

agat

cata

gacc

aaaa

aagt

cata

ccttc

gagg

tggt

agca

gtag

attc

cagg

agga

gaag

ggta

cttg

ctag

gtat

cctg

ggtc

agtg

gcgg

tgca

aact

ggttt

cctc

agct

gcct

gtcc

ttctg

tgtg

ctta

tgtc

tcttg

tgac

aattg

ttttc

ctcc

ctgc

ccct

ggag

gttg

tcttc

aagc

tgtg

gact

tctg

ggat

ttgc

agat

tttgc

aacg

tggt

acta

ct

1288

3497166

NO

cgcc

agca

tacc

agct

catg

tttca

gaat

ttctg

tcac

aaaa

agga

acac

aata

tttta

agttg

acta

ctgt

ggga

aagc

tatg

atca

ttcaa

taac

ctac

ctttc

tga

tagc

tcttt

ctca

gata

atat

aagc

tata

aacc

aaaa

tagt

cagc

cttc

acct

gattt

acag

tgcc

ctttg

aaac

ttcct

aagt

tttct

agcc

cagt

aaat

gctg

agc

tacc

agttc

tact

tcca

agct

agag

aacc

tgttt

acta

aagt

taga

agtc

tagt

gact

tcct

ctgt

caga

ctgt

ccca

gaat

gctc

tccc

tacc

ccca

acaa

ctgt

gtaa

gaac

cgtc

atta

gcca

tctc

caaa

ttgcc

aaag

tgct

cagt

ccct

tcg

1289

3618874

NO

gtaa

catg

catc

tgtg

tggg

aacc

t1290

3202840

NO

tttca

ctgc

tact

gcga

actg

gtcc

tgaa

ggtg

caga

tctc

ttaga

agga

ggac

tccc

acttc

ttggt

ggtg

gtcc

tcttt

ttact

ggat

gtgg

tccc

ctgg

aag

aact

catg

ttaaa

attc

atgg

aata

tcca

ccgt

catc

catg

tgtc

ctcc

ccgt

gagg

gagg

tccc

cttg

ttcct

ccac

ttcct

cctc

ttcca

cctc

taag

acct

ctt

ggag

ggcc

tcta

cttc

ttgga

ggtg

gagg

cggt

ccac

gtct

acca

ctttc

aaat

gatg

gtttg

ttggc

ttgttc

cacc

tcga

tggc

ttttc

catc

taat

gact

ttcc

attc

atgt

ctct

ggct

gcat

cctta

gcat

ctgc

tggg

ctttc

aaag

gtga

caaa

agca

aatc

ctcc

tgat

ttgttg

gtttc

atgg

tcttt

cacc

aaga

gtac

ttcca

cta

ttcgt

ccat

atttg

ccaa

atac

tgct

tcaa

gagc

tttct

cattt

gtttc

cgtg

ttaag

ccca

ccag

tgaa

cggc

tttcc

tggg

caat

ctgc

1291

3755656

—NO

catta

gggg

accc

tgcc

tgaa

tcttt

gcca

acct

gcaa

ggaa

actc

1292

2469949

—NO

tgcc

agtg

acat

ccttg

ggtta

ttcgt

atac

ctca

tgct

ttaga

ttcgc

ttctg

gttc

atgg

tgcc

agcc

ctta

gaaa

ctct

gggt

tcct

acct

gaag

ccgg

tctta

tca

aaac

gcca

cccc

tggt

tcca

gtttg

atca

gggt

aacc

ttgtg

aatta

gcaa

gcag

cagt

cccc

agtg

tgtg

ctga

catg

gagg

ttgga

gaga

aaat

agat

atgt

ccca

tgcc

tggt

ttcca

gcca

atac

tgat

gtcg

cggg

ttagt

ccag

cagg

ctga

ggct

gagg

cctg

tgac

aaag

tccc

tgca

tgga

ggtc

ttcct

gcgt

caga

gcct

agcc

ctgt

tcaa

ta

1293

2830605

—NO

gagc

tttct

aatg

gggg

tggg

aaga

1294

3235906

—NO

ttggg

gttg

atac

ccat

catc

gctc

ttaga

ctcg

gggt

tgat

actc

gtca

tcgc

tgtta

cact

cagg

gccg

atac

ctgt

catc

a1295

3616555

—NO

aggc

agac

atca

accc

tcta

agac

atttt

tttcc

tatc

ctct

ggga

atat

tact

ttttg

gaca

atct

tggt

ccat

tggt

aagc

tcat

ggga

atttg

tcag

agttt

ttttg

tttct

tttgg

ctca

tgttt

agca

tcga

ttggc

agag

tgttt

ggag

tcat

cc

1296

3369121

ELF5

YES

cagg

aattt

tgga

gcgg

gttg

accg

1297

3908978

—NO

tccc

atca

gcaa

catc

cgtc

atac

cctg

acgc

cc1298

2338495

—NO

aaga

gcag

ggga

ccta

tgat

gcag

aaag

tcct

ttgct

ggag

ctca

cagg

tcga

atttc

aggg

aagc

tgcc

caag

ggct

tgaa

catc

cctg

ctttc

aggt

tcc

ag1299

2452931

—NO

ccac

atag

tacg

gtgt

ataa

caag

gagt

ggtc

aaag

agttg

tggc

tggt

ggttt

ccttg

gcaa

agcc

aaag

tcag

tgag

tttca

ggat

ggcg

ttggg

ccttt

tgg

aggt

gtat

aaga

gattc

tc

1300

3448040

—NO

tgtta

agcc

ttcct

gaga

tcac

acca

aatg

tcct

tgat

ggga

attg

taaa

caac

cctta

cttc

tggt

ttcta

atga

tattc

cagg

aaag

gagc

ctaa

ctag

agtc

a1301

2823916

CAMK4

YES

gattg

tgga

aaag

ggat

atta

cagt

gagc

gaga

1302

3799998

—NO

gggc

atca

agaa

tttgg

acat

actg

gtgt

ctgg

tatc

gagg

ttcttc

agct

actc

aatg

cacg

tgat

gatg

gtga

tgat

catg

atgg

taac

aaca

gac

1303

2978095

SHPRH

YES

tcat

gaat

attg

gatg

gctc

tgag

gaat

cgtg

tgtc

tgct

gttg

atga

acttg

caat

ggct

acag

aacg

acta

agag

tgcg

tgat

ccta

ggga

gcca

aagc

ctaa

tccg

cctg

ttcttc

atat

c

1304

3475

634

—N

Oga

cacc

tcag

gtga

catg

cttta

tagt

tggc

ctga

gcct

tgac

ccag

tggt

tcaa

cctg

agttt

ggtc

ttggt

acca

ttcag

gtgt

ttgtg

agct

gaga

ctga

tgag

tagg

aaca

ggtg

tttta

tatc

tcgt

ctttt

gtca

aaag

taaa

gact

cattc

ctttg

gtaa

ccca

acca

aatc

agga

tcag

1305

3683

092

SMG

lY

ES

gtat

tctg

agca

cacc

caac

taca

g13

0640

2204

8R

AP2

CN

Ocg

ccaa

gtct

ctgg

gcta

tttttt

atttt

tgca

aatg

tgct

ttcta

atag

ccat

tgcc

ttcca

tgttg

tttac

ctaa

tcag

cata

tttttg

tctg

aata

cttg

aaca

tttta

aca

gtaa

cgca

ggtg

taga

atca

gaaa

ggaa

actta

tgca

gagt

aata

ttttg

gttc

agttt

taac

atcg

tgac

aatg

aggg

ctttt

tcta

gcaa

tgat

tttta

aatt

gtgt

aagt

ttgac

agta

tttta

ttgttg

ggttt

ttattt

gattt

tagt

tgtg

tgct

tttca

tttgc

agaa

gtta

gtaa

ctgc

agct

cacc

tact

gcac

caaa

gttc

tcga

tttta

ggag

ccca

gcttt

agtc

atttg

aaca

tgct

tcta

aata

aaat

aaaa

caaa

acca

aaac

tata

ctttt

gatc

tata

ataa

gagc

tcaa

taac

tttgt

caag

gaaa

gctc

taat

atat

gcag

tgat

ggttt

atga

aagg

gtgt

ggca

atttt

aaat

ttata

ttgtg

tgtg

atgt

tcaa

ataa

agtg

gtat

ctac

attc

atgt

gattt

atgg

gtca

gcat

gacc

atta

atta

ctga

gtag

aaat

tgac

taaa

ctttg

atttc

ctttt

tttaa

atcg

tgttg

cattt

gattc

ctga

gcaa

attc

cctc

aaag

tgaa

ctct

tgttc

ttaaa

ttttg

aattt

tatg

gtga

gattg

taaa

gata

gagg

caat

tgaa

acat

tgttc

ctta

tttat

gaac

tgct

tgaa

gtga

atac

ttaat

ttaag

tttgc

acttt

aata

cca

aact

taaa

acca

aaca

ctca

tttaa

aagt

aggt

taag

tgat

catg

gatc

attg

ttatta

gcttt

gtgg

ctttg

tgaa

attc

taaa

ggaa

tcaa

ataa

ttcat

catg

att

taaa

ttttc

taga

gattt

tgat

tttttt

ataa

tgttt

ctttc

ctgt

agat

tgtg

ttcttg

tttct

ctct

ctct

ctct

ctct

ctct

ctct

ctct

ctct

ctct

ctct

ctct

ctct

ctct

caa

aatta

cagt

gttc

attg

tcat

tgac

c

1307

3153

356

—N

Ottt

tctg

agga

atag

ggct

caat

ggtg

ggct

taga

atat

tgag

taca

ccat

gctg

taaa

caga

tatg

ctgt

catc

tagg

ctttg

ttgta

ccat

ttaga

gagc

acag

gca

1308

3529

618

PSM

El

YE

Sgt

ggat

gtgt

ttcgt

gaag

acct

ctgt

1309

3830

025

—N

Oaa

ttcat

tcgc

ctcc

ggta

cttg

caag

cctc

gctc

agtc

ttaag

caag

aggg

gatg

gattc

gccc

gcag

cact

gaga

atcc

aggg

gcag

gcgg

gatg

gcg

ttcag

gcgc

tgttg

ctag

aaat

ctct

gtct

ttact

ctgt

tttga

aggc

agca

tggc

aggg

tgaa

caca

agca

caga

ctga

aggc

agct

tgcc

gcgg

ttcac

atcc

tggt

caca

ccac

ttcct

gacc

atgt

cacg

tggg

caaa

tta

1310

3866

580

KPT

NN

Oag

ggat

gatc

ccat

tcca

ccct

gtcc

actc

tgga

tgag

aattg

gcca

cctg

atgg

ttattt

atac

gtcc

agaa

gaac

1311

2620

390

TG

M4

NO

gcca

cctg

ctga

cgac

ccttg

agaa

gctg

ccat

atct

tcag

gcca

tggg

ttcac

cagc

cctg

aagg

cacc

tgtc

aact

ggag

tgct

ctct

cagc

actg

ggat

gggc

ctga

taga

agtg

cattc

tcct

ccta

ttgcc

tcca

ttctc

ctct

ctct

atcc

ctga

aatc

cagg

aagt

ccct

ctcc

tggt

gctc

caag

cagt

ttgaa

gccc

aatc

tgca

agga

cattt

ctca

aggg

cca

1312

2693

884

NO

cagt

ctga

gttc

ctgc

accc

ttcag

1313

2724

817

___

NO

gatg

atgc

tgga

caaa

ctgc

aaat

cctg

aact

taga

gact

gttg

cagc

aata

acca

ttttg

actg

tgat

aata

tcat

tctg

ctca

agttg

1314

3718

581

SLFN

5Y

ES

ccag

tgac

ccgg

aaaa

ccttc

atga

aaaa

caac

tttga

acac

atcc

agca

catta

tcat

tgat

gacg

ctca

gaat

ttc

1315

2645

299

NO

ctgg

cagc

ctgc

tcaa

cact

ttaaa

tttta

tcag

tttag

tacc

tgct

gatg

cgtc

taaa

actg

ttggt

ccca

ttcta

gtttt

atac

ttaca

tatg

tagt

atta

aaag

cac

ttaag

agaa

atgt

agaa

tata

taat

cttta

taaa

agta

ttaaa

ggaa

ttattt

aaat

tgaa

tttgt

atcc

cattt

atct

tgct

tgct

aaat

agat

ttaat

tgga

gcat

cca

tttgt

ataa

cgtc

tggc

tattt

ctac

aatg

ttaaa

acag

tggg

ttgag

gaag

taaa

atttg

agtta

ctca

gtta

ctga

cata

gaaa

agaa

ccct

gtga

gacc

aaat

tcag

ctttg

gaaa

caat

ttagt

gtaa

ttattt

tgca

tatg

taga

taca

ccttt

gaaa

gcca

agaa

aggt

ttatg

attg

gatc

tgta

ctat

atta

attta

aaaa

caaa

ttattc

ttaag

tata

ttgta

gcat

ttctg

ttcct

gtaa

gtac

tttac

tcat

ctta

aatg

tact

gatc

atta

gcca

ccttt

ataa

aaag

aatg

tgcc

tgac

ccac

tagt

atttg

ata

gaaa

tatta

aaac

agtta

agat

cctta

aaca

tttct

gcat

ataa

tttttt

attg

agta

aatg

taac

ttaac

gtaa

gtag

ttcta

tgaa

gtct

gtgt

aaat

taaa

accc

tgttt

tgtg

taga

tgaa

gcaa

tcttt

ataa

gtttc

tgtc

atca

agac

tgta

ttttg

tgtg

ctat

ttttc

cata

gcta

ggaa

ggtg

gcaa

gtaa

aaca

tatg

cact

atcc

tag

aaac

atac

tgttc

cagg

taga

tctta

attta

ctac

ctgg

aatg

agcc

atct

tagg

tgac

cacc

a

1316

2927067

NO

aatc

tgta

gttg

taat

gtag

ccttc

tacc

taaa

taaa

agag

atcc

taac

ataa

tggt

tctc

atta

ctta

agcc

tcat

tatg

atca

agct

cttc

ccaa

ataa

tctg

acc

aa

1317

2434911

NO

ctga

gacg

atga

ttagt

agaa

ctga

gaag

tgcc

cattg

gtttt

ggtg

agat

agag

gtca

gaca

ttacc

ttagc

acttt

ttggg

1318

2916250

C6orfl6

YES

ggct

caga

gggg

tgcg

caca

acaa

cctta

t2

1319

3152957

___

NO

tctg

gcaa

aacc

cagg

tgcg

gtaa

ccct

gcag

cagc

ttcca

ctca

ctcc

tgca

atgc

ctga

ca

\1320

3190622

SPTAN

YES

gaag

ctttt

gaga

caga

cttc

accg

tcca

caag

gatc

gcgt

gaat

gatg

tctg

cacc

aatg

gaca

agac

ctca

IN)

1

1321

3508990

—NO

ggat

ttcta

tgcc

acac

tacc

cgta

acttt

gaaa

aata

acttt

aggc

tgca

gtttt

cagc

aaac

agga

cagt

cctta

gctg

ccac

atag

ctca

acat

aaag

tgca

caaa

aaac

ttcac

ggtg

ggac

agtg

aatc

ataa

attc

ccaa

actg

acgt

gtgt

ctac

agaa

caga

tg

1322

3567717

—NO

ttttc

cata

gcttg

gttc

tcag

gggt

tata

gatg

caag

aagt

tcct

ggaa

agag

ctct

aaac

caga

aaat

aaca

gtct

gctg

gtca

aact

caaa

actg

tcttg

gttg

atat

atga

gctg

gctg

tcttt

actg

ttacc

tcct

gtca

tgat

cattt

tgct

aattt

tctg

ctat

aact

agag

ggga

atgt

c

1323

3780094

—NO

tgcg

ttaga

agac

ctgc

cgac

aggc

cgga

taag

gcca

atga

gaga

ggga

acgg

agaa

gagg

ggca

cctg

ggttc

acag

gcct

taag

aaag

aattt

agt

tact

tattt

aaca

aatta

aaca

atgt

gtgt

cacg

catg

tagg

tctg

ggaa

atgc

atta

ttaaa

aaca

caca

gtgc

agag

gtgc

agca

ccag

cata

cggg

tgga

tt1324

3799938

NO

ggac

accc

tcaa

ccag

taac

acac

actc

tcct

tcttc

aatg

acgt

ttgtg

ttcct

agaa

tcca

ttttc

ctca

gtca

g1325

3932154

—NO

tcttg

ccat

accc

aagt

aggg

aatc

acttc

cagg

aaaa

caag

tcct

caag

cact

caat

gact

ttgta

aacc

catg

actg

aaac

aaga

ctca

tctg

aggc

agta

ggac

tggt

ggga

ttcta

ctga

cttc

ttagt

atca

catg

gcac

catc

acaa

atgc

attg

ttaga

gcag

caac

atcc

agag

ttctta

agct

tgta

ccct

aaca

1326

2534308

NO

cctc

acag

tgac

acgc

gatg

ttttc

aaaa

gtcc

atct

ttcca

cagg

atgt

ttaca

gcac

ccag

cggg

tagg

cagt

gcta

tttat

taac

cctg

ttgta

ctga

tgaa

caaa

ccag

ccgg

ctca

gggc

aggg

ggtg

agct

tgat

caag

atca

caga

cagg

aagt

gaca

gcgg

ggtc

tcag

ccca

ggcc

atgc

ctga

cacc

caca

ctc

ttctc

tggt

gggg

gcgc

ttcca

ccttt

gtcc

ctgg

aagc

ccag

cctg

acag

cttc

tgca

gtgc

ctct

ggca

gccg

ccca

caaa

ccca

gcca

ggca

aaat

ccca

gggt

gcca

gaca

ccag

gaga

aattt

ccag

ggga

atttg

gcca

tttgg

ctgt

ctct

tcac

ttccc

tgaa

aagc

caaa

caga

gaat

ggat

ttctta

tcac

act

gtag

caag

gcaa

tcaa

ctgg

aaaa

gaga

cagg

agga

gaag

tgtg

agga

ccaa

cagt

caca

ggga

ccca

ggaa

tcgt

gtta

gcca

ca

1327

3696944

—NO

gctc

ccaa

ggcc

caat

caga

taca

gctc

tcca

aacc

tgcc

agtg

ctgg

tgaa

cgcg

ctgc

tggg

agca

ct1328

3712853

—_

NO

ggcc

gtga

agga

agaa

tgcg

gtgt

t1329

3916807

—NO

ttcac

cagg

atac

gact

gttg

gacc

agct

gctg

gaga

tgga

cctg

ctac

ccct

cagc

agcc

tccc

cacc

acaa

gaca

agtg

atct

caat

gtcc

ccaa

acct

gtgg

gacc

ctgt

tcta

caca

cctc

atttt

tgttc

cggc

gtttc

atcc

tcct

tgtg

tgat

tgta

ctga

ttttc

atga

gaca

caag

ttact

tcttt

acat

ccat

attc

ccaa

agca

gggt

taca

tggt

agga

aaga

aagg

aagt

tgga

ggta

ctaa

gctc

attg

tgtc

tcct

c

1330

2381295

—NO

agga

agta

acta

gagc

cggc

atttg

gggg

tgttg

cgga

cgat

tctta

cgaa

tcca

gaca

atttg

ctct

tttaa

acgc

ggcc

ttgcg

gttg

tcta

acag

tgag

aat

agat

gact

aact

gaat

ttgtc

agac

tccc

tgcc

ttctg

tcat

aata

acga

cgca

gaat

tgcc

accg

ttatg

tgtc

1331

2608169

...

NO

gtat

gggg

agaa

cgag

gatg

tgat

a1332

2363544

—NO

ccac

aaga

aggg

ctag

agaa

atac

agag

atat

ttgaa

gagt

gtga

ggaa

gagt

atta

acac

acca

gtttt

cttg

atca

atag

1333

2407863

—NO

acat

ccttc

ttttc

ggcc

ttgaa

tcct

ttcttg

ctttg

caag

gaac

aattt

tcttc

ctac

tata

aact

acag

cact

aagg

tatg

gacc

ttaga

aatta

tata

gtct

aatt

ctct

gctg

acac

acaa

atcc

cttc

aaca

acaa

agaa

tcat

aagt

tcac

attg

aaag

gtct

ctcc

aaat

ctcc

cata

aatc

taca

atat

tcttg

atgt

ttaaa

attta

ggat

aata

gaga

attc

acta

attc

ataa

gaca

aagt

acca

atgt

aata

attc

tata

aaat

gtca

taat

ctgc

tttcc

ttgta

acttc

tgcc

tattg

actc

1334

2920969

FIG4

YES

agga

tcct

cggg

ctta

tttcg

agcg

gtttc

agct

tttgg

tg1335

2949119

LTB

YES

tgcg

tggt

gcga

gtgc

gtga

atat

tggg

ggcc

cgga

cgcc

ca

O\

cattg

ggcc

ttcca

tcat

caga

aagc

tcct

catg

ccac

atct

tgac

acat

tattc

ccgt

cctc

ctg

1336

3241194

NO

1337

3447084

...

NO

agga

tgtg

agac

tgcc

gtgg

atat

cagg

gaag

ggag

actta

taag

aagg

agaa

atttg

gtca

actg

tgtc

aaat

gcttc

agcg

atca

ggat

gagt

aatg

agga

acgg

ccat

ttgat

ttgat

ttgat

cattc

agat

atct

ttaaa

gacc

tttaa

gagg

gcag

tttca

gt

1338

3626136

—NO

acga

ccat

gcgc

actg

agaa

acag

gcac

cagg

atgt

cgag

aacg

gcaa

tgta

tttgc

tcac

aaaa

agct

ctac

ttcac

acac

cacc

tgtg

catg

agcg

tgc

caca

tcaa

aatg

a

1339

3800039

NO

cata

atca

ggtc

ctct

gcaa

gtgg

gagt

ccaa

ctgt

gacg

cagc

cccc

ccac

gttc

aaag

catc

ccttc

agct

tccg

gcaa

tctc

ctct

ccag

g1340

3887175

NO

gccc

tggt

tgca

actc

tgct

ggtc

t1341

4011861

...

NO

atga

gggg

aacg

gtag

ctga

caat

agca

gagg

aggg

ttttg

cagg

gtct

ttagg

agta

aagg

atga

gaca

gtaa

gtaa

tgag

agat

tacc

caag

aggg

tttg

gtga

tgga

agga

agcc

acag

gcac

agag

aaca

caga

atca

cttta

tttca

tatg

ggac

aact

ggga

ga1342

2320367

FBXO4

NO

ggta

caat

ggca

tggc

ttctg

tcta

aggt

acag

aggg

gttg

gcat

ttcag

gaac

cagg

ccat

caca

gaaa

cagg

ttcat

gggc

agac

ccct

cagt

gagc

tg4

cagg

tatc

tcac

ctgg

cagc

cgtc

cagt

actg

ctgg

cttc

ctct

ggag

gccc

agcc

acag

gctg

gggt

tggg

gtgt

gtgg

acat

ctct

gggc

agct

cttg

agt

ccac

cttg

tgcc

agat

cagc

agtg

ccac

cc

1343

2680360

...

NO

gagc

tggg

tcag

ttgct

ccat

tatg

tact

ttggt

ttgca

g1344

2866718

ARRDC

YES

actc

gcta

cctc

attc

gaag

gccg

acat

ggca

gtgt

gcgc

tattg

ggtg

aaag

ccga

attg

caca

ggcc

ttg3

1345

3251759

N NO O

gaca

acct

tcaa

tgca

ctgg

tact

ttgta

ccct

gacc

tcta

ctgt

gatg

aaca

ctca

acttg

ggca

agga

1346

3742688

NUP88

YE

Stg

tgttg

agttg

gagc

ttgct

ttgaa

1347

3772092

LOClOO

NO

tggc

tgtg

cctc

tcga

tgat

gatta

agat

ttcaa

tattt

acag

caaa

acca

caaa

gcaa

atga

taga

ataa

agca

aaac

aatg

gaaa

atct

gagt

tcac

tcgt

g131096

agag

aggt

acgt

atgt

gagc

tctg

agga

aatta

caga

ggga

acgc

atgc

agcg

ggac

agct

ctcc

caat

cgca

gcgt

gcaa

agta

gaca

tcca

1348

2596545

—N

Oga

cagc

agag

ctat

ctat

cagt

tcct

ctga

acttg

ttctg

aatg

agct

tttct

tact

gttc

agtc

ttcac

tctc

ctat

tact

gtttt

gcttc

ctca

taga

attc

caga

ttagt

gggc

ccct

ggaa

gttc

agct

ggta

gatg

agaa

aact

gagc

ccat

tgaa

gtta

aagt

cacc

cagc

tagt

cagg

gttg

atct

tccc

aact

caga

gtcc

cctg

ctta

ctta

aact

tttat

atcc

aaca

ggttt

acttc

ccct

ggaa

actta

tttgg

tattt

tttat

tttcc

atct

ccat

gccc

tcga

tagg

tttc

1349

2928626

—N

Oca

gccg

ccaa

agac

gcct

gaga

gcgg

cagg

ggag

tgtg

ttgcc

ttagg

acaa

tagc

aaac

tggg

acgt

ggta

gagt

ctgt

aaat

tcca

agca

ctgg

g1350

4035053

—N

Oca

tggt

atca

tgtg

cctg

taat

gtc

1351

2487210

ANTXR

YE

Sca

gggt

caag

aaca

acca

gcca

gcc

113

5228

9195

5—

NO

ggcc

cttg

acaa

atgc

ctga

aatc

t13

5330

6118

5E

RV

WE

NO

ctct

tcaa

acaa

caac

cagg

agga

a1

1354

3104349

—NO

atgg

acaa

gtta

ggcc

ctcc

acttc

gaac

ggga

agac

ttgtg

caaa

ggttg

tatg

acag

tgat

acaa

aatc

agac

agtg

cc1355

3915245

—NO

aattg

ggttc

ttgag

gtgg

attg

gagg

agaa

cagc

ctct

ggat

gtct

gctg

ggca

gtga

cgat

gtgt

ctgg

aggc

tttga

cattg

gattc

atta

ggca

ttgct

aat

gtac

acaa

aaaa

tgta

gcaa

aaat

gatg

cctg

tttct

gggt

gaga

acat

ctg

1356

3961553

—NO

ctcc

cagg

tttac

aggt

cttg

actc

agta

cttc

atca

gcaa

tagg

ttgtg

gtca

cagg

aaat

ggaa

gctg

cctc

agga

cctg

tagc

aact

tgcc

tgca

tgct

ggg

ttatg

ttatc

ttttg

agtg

gtgc

ccaa

tacg

aggt

gtct

aggg

gaaa

gtct

taag

tggt

tgga

gccc

atga

ca

1357

2523501

NBEAL

YYEESS

tctc

acag

tgga

attc

gtcc

ctttc

tt1

1358

3601127

NO

gtgt

gtttg

tgca

agca

tgtta

agca

tttct

ctgt

cttg

tgttc

att

1359

3892321

___

NO

tgca

gggg

tgtc

caga

cggc

ctgg

tgca

ggat

ccct

ttgat

gtgg

agga

1360

3087823

___

YES

ggag

gatg

ttcgg

acta

taga

ttcag

ctgt

ggga

tctg

gttc

tgta

gctg

agag

caca

tcgc

taaa

cata

gatg

tgca

gtct

gagg

cttc

a1361

3337295

___

NO

aagg

ctac

aact

gtgc

tctta

gagg

caaa

agaa

gaaa

atga

gact

gcca

ggca

tgaa

taat

gaga

aatc

tttga

tgga

atta

gcca

tgca

gaac

agat

a1362

3528558

TRA

@NO

tcttt

ggtc

ccgg

aacc

agat

tgtc

cgtg

ctgc

cct

1363

3536444

NO

ctttt

ctct

gtag

ttggc

ggaa

tcag

ctca

gtta

cattt

tttac

taag

ttacc

caca

ttctg

acac

tcct

tgac

agttt

taag

atct

tcttc

taac

acac

ttgaa

taga

atgg

atac

tgga

atct

atttt

gaca

gctg

ttgaa

aatc

tattc

tgttg

ttaca

ggag

gtta

agga

ggtta

tttgt

aaca

ctgg

gatta

tttaa

tgaa

ccttt

tgaa

aagg

tgtg

caga

ctgt

tcag

gcaa

atag

tattt

tttag

aattt

aaat

gattt

tggt

tttca

cagt

taaa

ttatc

aaat

gtaa

tgct

tttaa

gaat

tata

cacc

tagt

aata

tttttc

atta

atttt

ctcc

acca

gtgt

agta

atag

taca

ttaca

atgt

tctc

aatta

ccgg

tgcc

ttcta

aaat

gcag

gtgt

agag

tcttt

aaat

acag

ctag

tcta

ttgcc

agct

gtcc

cata

gata

acct

tctc

tttaa

aagt

gacc

tttga

gcaa

tttca

taaa

gaat

aaat

atttc

tagt

tttttg

ttgct

gaac

tgct

aaaa

gatg

gttc

tata

catg

taa

cagg

tggc

tttag

ttggg

ttgct

t

651

1364

3823557

RAB

8A

YES

atgg

cgaa

gacc

tacg

atta

cctg

ttcaa

gctg

ctg

1365

2707806

—NO

caga

ccct

tgtg

gtcg

agttg

tttac

tttgg

taat

taag

tacc

tgac

tctg

ctgg

acgc

tcttc

gcgt

ttcag

aagc

gctg

tttgg

cattg

taca

gtct

gagc

gtga

gttg

aattc

c

1366

2849541

NO

gttc

ttcat

aaat

cctc

cact

caca

agct

tgca

gcct

ttcct

atca

cagt

cata

tcca

atct

caat

tccc

ctgc

ccag

tata

atgg

gact

cga

1367

3795889

—NO

acgc

tgac

cagt

gacc

gagg

acac

agttg

tgtg

ttagg

ctcc

atca

cctg

ctgt

acttt

gagt

tggg

aaat

tttca

tcat

ctta

gaaa

ctgg

gtca

tttta

tcag

agt

ctag

agtc

agat

atag

aaaa

agttt

gtgg

ctat

ttctc

caat

ttata

tgac

taag

gtcg

ggta

tcttt

ttcaa

agtg

tcta

attg

aaat

tgaa

aagg

cagc

aattt

aaag

ttgct

attg

caag

ggca

gaaa

atgg

tctta

agaa

agcc

agct

ttcaa

attg

aata

aaca

tgac

tgcg

ttcac

tttttg

agc

1368

3895772

NO

gaaa

caaa

ctga

caat

actc

gtga

aatc

aaca

ccca

gatg

aggt

agac

cagc

actc

ca1369

2920915

—NO

ccaa

ctca

cacc

atag

cagc

gctc

att

1370

2971825

MANIA

YES

ctgg

aggc

agca

gtat

tctg

gcag

aattt

ggaa

ccct

gcat

ttgga

gttta

tgca

cttg

agcc

actta

tcag

gaaa

ccc

1371

2990655

NO

ggttt

cttg

ataa

ctgc

tcca

ctta

gaga

aatg

agct

gtga

tctg

tgta

gtttt

ggaa

aatg

ggta

gctg

gggg

gatc

atct

ttaaa

caat

ctttt

tcat

gctc

atca

cgaa

atgc

tttta

caat

aggt

ttattt

tgac

tttgt

gttta

gaat

tttttt

tttttt

ttgct

ttttg

ctat

agac

tcttt

aaaa

aagt

tgttc

ttctg

gata

ttattg

atag

atgg

aac

aaaa

ttcat

gtcc

cttg

cttg

aatc

tttta

gcga

gcta

ttcag

agat

tcta

tatc

ccca

tttac

tcat

ggttt

tttca

aggt

gaat

gaaa

caac

atac

cctg

ct

1372

3198975

MPDZ

NO

tgca

ctgg

tcct

gaca

atttt

tatg

ctgt

gttc

agcc

gggt

cttc

aaaa

ctgt

aggg

ggga

aata

acac

ttaag

tttct

ttttc

tcat

ctag

aaat

gcttt

cctta

ctg

acaa

ccta

acat

cattt

ttcttt

tcttc

ttgca

ttttg

tgaa

ctta

aaga

gaag

gaat

atttg

tgta

ggtg

aatc

tcgt

tttta

tttgt

ggag

atat

ctaa

tgttt

tgta

gtc

acat

gggc

aaga

atta

ttaca

tgct

aagc

tggt

tagt

ataa

agaa

agat

aattc

taaa

gcta

acca

aaga

aaat

ggct

tcag

taaa

ttagg

atga

aaaa

tgaa

aat

ataa

aata

aaga

agaa

aatc

tcgg

ggag

tttaa

aaaa

aatg

cctc

aattt

ggca

atct

acct

cctc

tccc

cacc

ccaa

acta

aaaa

aaga

aaaa

aagg

tttt

ctaa

tgaa

aatc

tttaa

aaat

actg

tcag

tattt

taaa

atttt

caac

agta

ttata

aaaa

cattg

catc

tccc

cacc

tcta

atat

gcat

atat

atttt

tcct

gcta

aaat

tgg

tttct

acaa

ttgag

taaa

tggc

aaat

acat

gaag

caat

gtcc

ctaa

atttt

ataa

agaa

atta

tattt

aatg

caca

tttca

atttt

cattc

ttattt

ttgac

ctttt

gta

aaat

atttt

catg

ttgct

ataa

gtaa

atga

tgat

gcca

cccc

atgt

tgac

tatg

gtttt

tcta

gaaa

gcaa

ctat

gctg

ctaa

ccat

agag

gaac

atag

aagg

gtt

ccag

aatc

tttag

tgct

ggttt

taac

aacc

gatg

caac

atta

aaaa

tgtg

ttagt

gtgc

tgtg

caat

tggt

tttca

attc

atat

taat

ctta

atga

caga

gaac

aatg

tgtta

ctaa

ttattt

tggt

tgta

tgcc

atta

gtaa

attg

atag

aaaa

atta

aggg

gatta

acat

aact

tcat

ttcat

tgac

ttata

ttaac

atct

tata

atac

aata

gttta

agac

taag

ggaa

acag

atgg

agct

gttta

ttgag

acaa

ctgg

tga

1373

3652

974

—N

Oct

gaca

tggt

gtgt

caca

aaga

gctc

c13

7436

8029

6L

OC

388

NO

gtag

accc

taca

ccat

tcct

cagc

c21

0

1375

2530

462

CO

L4A

YE

Sttc

cctg

ggtta

atgg

gtga

agat

ggc

313

7625

5027

2—

NO

cagg

ggca

agag

ctag

ttaga

aaac

tgag

ctcg

ccct

gtct

ctaa

tgtc

tggt

gagc

tgct

ctcc

tctc

tcta

caat

atat

cacg

ggta

gtttc

atgt

caac

aaa

1377

3118

585

—N

Oga

atat

gttg

ttaag

tggg

cagc

at

1378

3403

090

C12

orf5

YYEE

SSta

agttt

gctc

gcttg

gtca

agtc

ctac

gaag

ccca

ggat

cctg

agat

cgcc

agcc

tgtc

aggc

aagc

tgaa

ggcg

ctgt

ttc7

1379

2524

930

___

NO

tgtg

aact

tggg

ttgtg

tcgt

agaa

aatg

tgag

tgtc

agag

ag

1380

3125

787

CN

OT

7Y

ES

ggtta

cgac

tttgg

ctac

ttaat

caaa

atcc

taac

caac

tct

1381

3171

102

___

NO

ccaa

ggac

tggc

agga

cgtc

agtg

atgc

tggg

1382

3250

113

KIA

A12

YE

Scc

tgag

cata

tagg

ggaa

gatg

ttcttc

gccc

tgcc

atgt

tagc

taag

tttcg

agttg

cccg

tctc

tatg

gcaa

aatc

atta

ctgc

agat

ccca

agaa

agag

ct

79

ggaa

aattt

ggca

acat

cattg

gaac

atta

caaa

tttat

tgttg

atta

ctgt

gaaa

agca

tcct

gagg

ccg

1383

3747

008

...N

Ogg

tgac

tgga

ccac

gcag

gtag

tttct

catg

aatg

attta

gcac

tgtc

cccc

tact

gctg

tctc

gtga

taga

gttc

tcat

gaga

tttgg

ttgca

taaa

aagt

gtgt

agca

cctc

ccct

ctct

ctttt

cctc

ttgct

ctag

ccct

gtga

agat

acct

gctc

tggc

tttgc

ctttt

gcca

tgag

taaa

agct

ccct

gaga

cctc

ccca

gtca

tac

ttcct

gtac

agcc

catg

gaac

catg

agcc

aatta

aacc

tttttt

cttta

taag

ttacc

cagt

ctca

ggca

tttct

ttata

gcag

tgtg

agat

tgaa

ccga

taca

gac

aaca

ataa

caaa

aagt

agat

aaat

atga

aggc

caga

gaaa

tggc

aact

tcttc

acga

aggg

aagc

tgct

tatc

ctca

agca

agtc

agttg

agga

ctat

cctg

tgag

ctat

tttcc

gtgc

cttg

ttttc

cact

cata

cagg

gaag

tatg

ccct

ggtg

tctc

acag

ttgct

tcag

ttcttc

tttac

tggg

accc

taaa

tata

ataa

caca

ctga

acca

ctca

acttc

tcag

acct

tcaa

tatc

cctg

gggc

tttttc

tcaa

atgg

acac

agca

tagc

tttca

gaaa

gctg

aata

atgt

agac

aaaa

gaag

tctc

cct

cacc

ctttg

atta

tgga

aaac

caaa

gattt

attc

agtg

ccaa

ggat

aaga

aagg

aagg

acttg

atca

acaa

ccac

tgtta

agat

tttga

ccca

ttcac

tact

tca

cgtg

aact

ccca

ggga

aatg

gaaa

atga

aaga

aggt

ctcc

gcgg

taga

ggga

taac

aatg

1384

2406

715

NO

acag

agcc

ctga

ttcca

cata

catg

agct

ccca

tgtg

tggc

tggg

gctc

tgct

gggt

cctg

gggg

cagg

agga

ggat

ggag

aggc

aggc

ccta

ccat

ggag

gagg

ttgtg

atct

aggg

gcag

gctc

ctaa

ccag

ttaac

atgt

gcac

agttt

ggca

agtc

tctc

acag

aagt

ctat

agca

tgtg

gggg

aacc

cagt

ggaa

gaag

tgat

cgag

ctct

agga

tgag

gagg

agac

tggg

gaga

acttc

agag

agcc

ctta

gaac

ttgaa

ctgg

gact

gggc

ac

1385

2808

962

ISL

lN

Occ

tcct

tggc

tgaa

agag

tcct

ttcag

gaag

gtgg

agct

gcat

tggt

ttgat

atgt

ttaaa

gttg

acttt

aaca

aggg

gtta

attg

aaat

cctg

ggtc

tcttg

gcct

gtcc

tgta

gctg

gttta

tttttt

acttt

gccc

cctc

ccca

ctttt

tttga

gatc

catc

cttta

tcaa

gaag

tctg

aagc

gact

ataa

aggt

ttttg

aattc

agat

ttaaa

aac

caac

ttata

aagc

attg

caac

aagg

ttacc

tcta

ttttg

ccac

aagc

gtct

cggg

attg

tgttt

gact

tgtg

tctg

tcca

agaa

ctttt

ccc

1386

2849

483

...N

Occ

tgttg

gtgt

gtcg

ataa

tggc

aagg

tctg

cagt

gacc

cagc

agtg

gctg

aggt

gggg

ctgg

ggct

gaga

acct

gatc

cctg

agag

gcca

tttat

tgta

aga

acag

gcaa

catg

gcag

ggaa

gtga

ccag

gaac

tagg

acag

gcag

taag

tggg

agag

aatg

acgg

caag

cctg

gagc

tgtc

ccag

aggt

gact

gacg

gatg

ctgt

acaa

ggtg

gaa

1387

2868

168

ER

APl

YE

Sat

ttgcc

ctac

agat

ggtg

taaa

aggg

atgg

atgg

ctttt

gctc

taga

agtc

aaca

ttcat

cttc

atcc

t

1388

3082

899

AR

HG

EY

ES

atgg

agttc

gagt

gaat

ttgaa

agtta

cgaa

gagc

agag

tgac

tcgg

agtg

caag

aatg

ggat

tccc

aggt

ccttc

ctgc

gcag

caac

caca

aaa

FlO

1389

3505

964

CE

NPJ

YE

Sgc

tgag

aacg

catc

tttag

ctaa

acttc

gcat

tgaa

cgag

1390

3522

535

DO

CK

9Y

ES

caaa

gcta

attg

agcc

actc

gact

atga

aaat

gtca

tcgt

ccag

aaga

agac

tcag

atcc

tgaa

cgac

tgttt

acgg

gaga

tgct

gctc

ttccc

ttacg

atga

cttt

1391

3404

455

NO

cact

agac

agca

attc

agag

cctc

caaa

ataa

agaa

tattc

ataa

aagt

aaca

atag

aggt

aaat

ataa

aacc

caga

atta

ctac

atgt

gtca

tata

gttta

taa

cttc

tcct

attta

tagc

tttct

atat

ttata

tttat

ctat

aact

tcat

aggc

aaat

gaat

aaaa

atta

taaa

tatg

atag

tggt

cata

taat

gtat

aaag

atgc

aatc

tgtg

acag

tctta

tgaa

gcag

ggat

gaag

acat

atag

gatc

aaaa

tgttt

gcat

agtta

ttgaa

gcta

tgttg

atat

tatg

aaat

tata

ttgtta

caag

tttaa

gatg

ctaa

ttata

attc

tcaa

ggta

acca

ctaa

taaa

atta

ccaa

aatta

tgca

gaaa

agga

aaaa

agaa

aaac

aata

cact

ataa

aaaa

ccaa

ttaaa

taca

aaaa

aagt

cag

taac

agac

aact

tgag

aaac

aaag

acat

ataa

gata

taga

gaaa

acaa

atga

ttaaa

tggc

aaaa

gtaa

atct

tgttt

tagt

aatc

acat

taaa

taga

aaag

gatg

aagc

catc

ctat

taaa

gggc

tgag

actg

acaa

gttg

gcta

aaaa

ctaa

aata

aatta

aaaa

gaaa

aaca

agac

tcat

ctac

atgc

tgtc

tata

agag

acttg

cctta

gata

taag

gaca

caaa

gaag

ttgaa

agta

aaag

gact

gaaa

aaga

tattc

cata

caaa

cagt

agta

acca

agat

agtg

ccga

gtgg

ctat

atttt

tgt

caaa

caaa

ataa

acta

aagt

aaaa

tttac

aaga

gaaa

aaga

aggg

catta

tgca

ttgac

aaaa

atttt

gaca

tagc

caaa

taat

tatg

ttata

aaat

atat

gtac

ttaat

aata

cagc

ctca

aaat

atat

gaag

caat

aattg

ctat

aattt

aagg

gaga

aaag

aaca

gttc

tatg

aaaa

gtta

gaga

atga

aata

ttcca

ctttc

aac

atga

gatta

aaca

acta

gaca

taag

atca

ataa

ggaa

atag

aaaa

tttga

acaa

cact

ataa

acca

atta

tcc

1392

3309338

—NO

ttcca

gctc

atcg

gcgt

tgag

gtgc

ac1393

2475878

NO

gctg

ctga

gtct

caaa

acag

ccaa

a1394

3032635

—NO

gagg

ctcc

tcttc

ctat

ggat

ttgct

tcaa

ggag

gtca

gggc

1395

3475556

VPS33A

YES

atta

cattg

agga

ttgta

tcgc

ccaa

aagc

actc

gttg

atca

aggt

gtta

agac

tagt

ttgcc

tcca

atcc

gtgt

gtaa

tagt

gggc

tcaa

ac1396

2930679

NO

gatc

aaca

ttctta

atga

cata

agag

aagg

gagt

tgca

ggtg

gatc

taag

ggaa

aact

gttc

cagt

agta

aagg

agca

gcaa

atcc

gata

gccc

taag

gga

1397

3489376

CDADC

YES

ggat

cata

aaac

agga

gttg

gggc

ag

1398

3933755

NO

gtttg

cattt

gacc

atgt

cgtg

ggca

ggag

a1399

2430088

...

NO

tcat

tctta

aggc

taag

gtgg

caag

ataa

1400

3420474

...

NO

atgg

aagc

atgt

tggc

gtca

tcag

caga

gaca

ggga

aattg

ggaa

ggag

agga

gagc

ataa

ttagt

gtgc

agaa

acttg

gaaa

tgct

gaca

ttgga

ctcc

tggc

aga

1401

3956302

PITPNB

YES

gact

gtcc

ccag

atgt

gtgc

ctat

aagc

tggt

gacc

atca

aattc

aagt

ggtg

ggga

ctgc

aaag

caaa

gtag

aa1402

2334264

hCG

18

NO

ctgc

tcgc

tgag

atag

acac

atac

ctga

ttgcc

tcct

ttgga

gagg

cttg

tcag

aaac

aaaa

taat

gcaa

ccat

ttgtc

tctc

agct

acct

gcga

cctg

gaag

c20661

cccc

tccc

cact

tcga

gttg

tccc

cgcc

tttct

ggac

ggaa

ccaa

cgta

cttc

ttaca

tata

tcga

ttgat

gtct

catg

tctc

ctta

aaat

gtat

gaaa

acaa

actg

tgcc

ctga

ccac

cttg

ggca

catg

tcgc

cagg

actc

cctg

aggc

tgtg

tcac

gggc

acgc

atct

tcaa

ccttg

gca

1403

2358

760

SCN

Ml

NO

cagc

ctgg

tgcc

ctat

taat

aaga

ctgt

caaa

aaga

ggtc

tttgc

ccttc

atgt

tgtc

tgcc

tgct

tctc

cact

acca

ctca

aagt

ccttt

cccc

cttc

aaat

caca

taag

gact

gcag

gtag

gcac

tagg

ggga

cctg

gcca

catc

tgga

aaca

gggc

tgtg

gcta

agttc

cctg

tgaa

agta

gaag

agtc

aaaa

ggca

ttggc

agg

gtta

tggg

gaac

acca

aggg

aggg

aaca

cccc

cacc

tcct

ccta

gtaa

cctg

aacc

tccc

tgcc

tgct

gatc

ccca

gagt

ataa

ataa

tccc

ctgg

tga

actg

gcag

taac

ccttg

gggg

ttagc

gcca

agat

tctc

accc

caaa

gccc

aagg

aagg

aggc

aggc

aaaa

tgga

taga

aggg

ctttt

attta

cagg

aaag

gagg

acag

atga

ggat

ttaag

tgtc

cagt

gctc

ccag

cgct

agttg

gtaa

aggg

aaat

gcag

tgtta

tctc

ttcttt

tgct

ggcg

acct

gtaa

1404

4005

886

CA

SKY

ES

tcat

caca

aagc

accc

agac

cggt

ttgcg

t14

0524

4019

1__

_N

Oct

cctc

accc

gcat

cata

actc

ctct

tcaa

g14

0625

6196

8SU

CL

GN

Oaa

ctgt

ggaa

tgga

tcac

gtag

acat

gtaa

ccca

gcag

cagt

ttgct

tctg

ttgtc

cact

gatta

atca

gcct

atgt

gcct

gaca

ctgg

tcttg

ca1

1407

3216

427

NO

atgt

tgag

aaag

cata

tgca

tgtg

acag

ggcg

gattt

gtta

gaag

c14

0832

3590

9__

_N

Ogt

taga

ctcg

gggt

tgat

atct

gtca

tcgc

tgt

1409

3469

137

—N

Oag

caac

agaa

agct

cgtg

gtgt

tcct

ctgc

ctca

aagg

ccaa

acgt

ctgt

gggt

tttttg

tcttg

gctg

ccga

ccgc

agca

cgtc

acac

tgttt

gaaa

tttgc

agc

tgcg

atca

tttat

cttc

aggg

gaca

gggg

t

1410

2343

471

NO

gaca

gattg

aaag

aggt

ggtg

aagc

1411

2464

386

—N

Ogg

taca

caca

ttagg

agac

tgca

gtttt

ggtg

agag

gtga

tgga

agct

cgag

acta

gtga

ggaa

aagg

gagg

tgtc

aaca

tgag

ccct

agat

tcttg

gagt

ccag

aact

tgaa

ga

1412

2672

266

AL

S2C

NO

gtgt

gagc

atgc

acag

gtta

gggt

gggc

tgL

1413

3730

349

NO

tggg

ccttt

caaa

ttgag

tcta

agttt

aaaa

gata

taaa

gagg

tgtg

gggg

aagg

gcat

tcct

ggca

gagg

gaag

agca

tatg

caaa

ggtg

tgga

ggcc

taga

acta

cact

gcag

cttta

aggg

gtgg

tgag

tgat

ggcc

gggc

accg

tggc

tcac

acct

ataa

tccc

agca

ctttg

ggag

gcca

aggc

agga

ggat

tgct

tgag

ctca

gtag

ttcaa

gacc

agcc

tggg

caac

atag

cgag

accc

tgtc

tctg

caaa

atat

tttta

aaaa

atta

gctg

agtg

tggt

gatg

cacg

cctg

tcta

ctag

gga

1414

3755

723

ME

Dl

YE

Sgg

ctcc

tcca

tagc

agag

aaat

ctta

tcag

aata

gtcc

cagc

tcag

acga

tggt

atcc

gacc

acttc

caga

atac

agc

1415

3861

643

—N

Oct

ggca

agca

gacg

ggttt

ggaa

taga

cattg

gaag

aagc

tttta

gggc

atcc

taga

cagc

gttg

cgat

gcttg

gggc

aggg

gcag

gaaa

aagc

cact

gat

ggac

tttca

gggc

agag

ctgt

aatc

gagt

tgat

gtttc

agat

ttagt

cgaa

gggt

gtga

gagg

gctg

agac

ggag

aaag

tggt

gtgg

caga

agag

gttg

ctgg

tggc

catg

ggtc

gggg

tgca

gatta

tgag

agaa

ctc

1416

3542

787

PCN

XY

ES

tttga

tcct

atgt

ggga

gcga

ctga

aaat

agaa

tgag

cttg

gtta

agca

cctc

tcct

ttgcc

1417

2468

417

RN

F144

NO

tgcc

acca

aagg

catg

gctg

tggg

cA

1418

2520

238

NA

Bl

NO

ggga

ggaa

cattt

aagc

tgat

ggaa

gtgg

aagt

ggaa

gttg

ctgt

acat

tggc

agca

aggc

ctcc

gagt

tagc

ttttg

aatg

cagt

taac

tggt

ttctc

ttaac

tgtg

gaat

tcat

tgaa

aagt

caga

ctcc

gagt

ggtc

gttc

cagg

atat

ctt

1419

3129693

—NO

cagc

ctgt

gtgt

actc

atttc

cttc

tcttg

agta

ccac

taat

ttgat

agttc

acgt

atcc

tcta

ctaa

gagg

taga

gtga

gaca

gctta

ggga

catc

agaa

gtac

tac

tttcg

gttc

ttcca

catg

gaaa

catg

agga

acga

ggaa

taag

tattc

tttcc

ctaa

cact

taca

gtgc

actta

agac

aaag

tttttt

tttttt

ttgga

ctga

atat

acg

tcga

tgga

caca

ggcc

caga

tatg

gaga

aagg

gcag

gtttc

ctct

aggc

aaga

tttgc

acgg

ggaa

cctg

a

1420

3845840

—NO

cctg

gatc

cctg

aaga

ctgc

tctg

agat

cgat

cagc

caga

gaga

aaca

gaga

gaaa

gctg

gctc

agcc

ctga

aggc

tttga

gcaa

aagt

ttcag

aagg

agc

tgga

agga

gaca

acag

cccg

ttctc

cctg

agct

gtgg

ccgg

gagg

gccc

aggc

cagc

acca

cgat

gtac

agat

ggcc

cagg

gggc

tcga

catg

agtg

aggg

ctga

agttc

gtgc

aacc

ccaa

ccgc

cacc

cctg

aattg

ggca

gaac

caat

tttttt

ctta

gcac

ctgt

ctga

ctct

gctta

ccat

gaca

accc

caag

ggcc

cccc

agaa

ttgat

atcc

aagt

gcct

ttagc

ctat

caaa

gaca

ggag

gggg

tgca

ttctc

ggcc

aggt

tagg

gttc

acag

agca

tccg

tata

tta

1421

2621

185

NB

EA

LY

ES

ggct

gtag

acct

ggac

catg

tgac

agat

gagc

ggga

acgg

aagg

ctct

ggag

ggca

ttatc

agca

acttt

gggc

agac

tccc

tgtc

agct

214

2228

7123

4—

NO

tttgc

tgcc

atcc

atag

tcttt

tcct

aagt

atca

caaa

agga

tatg

cctg

ccaa

tctc

ttaaa

aaat

gaca

atgc

agac

ttgtg

ctca

aaat

gaag

ctac

agat

ttaga

acct

caga

ttcaa

tgaa

ctaa

aagg

agaa

tata

ttaaa

tgtta

aattt

gacc

tcag

aaat

tcca

ctat

acta

agga

tgttg

ccta

agac

ctct

caaa

gact

gagg

acca

gcag

aaca

ctgc

ccat

ttcac

tcta

gaac

caca

caca

agtc

tgttg

ttccc

aagc

caat

gtga

aagc

tata

agcc

ttgag

actc

aaaa

gagc

aca

ggtg

tcca

cagg

tgac

ccaa

acat

caaa

1423

2904825

C6orfl2

YE

ccag

gggc

tcac

tttct

ccaa

caaa

a7

1424

3133366

...

NO

gtgt

cagt

acag

ccgc

gtgg

caga

gctg

a1425

2577848

NO

ggct

tgca

tcag

caca

cattg

taca

gcct

tgca

aatta

caca

gaaa

ttgaa

aaga

aggt

tcct

tgttc

ataa

gtgc

aatg

aatc

tttga

tgtc

cagt

gatc

cgct

gcaa

acaa

tgaa

aaca

aact

gtaa

agca

ctta

agaa

gtttc

cagc

actc

atca

aatg

cattt

cctta

ggtg

acaa

aaaa

tcca

caag

gaga

atgc

aaat

aagt

ggca

tttag

ttatta

gaga

gata

cttg

aaaa

aaaa

aaag

tgga

agta

ttttc

ctgc

ttaga

atga

tttct

gttc

ccct

ttgaa

tgta

agtg

gttta

agag

gcat

taag

aaca

taat

ttattt

tata

ctta

atgt

tcac

acta

ccta

aatg

aata

agga

aagg

gccc

taca

agga

agag

ttatg

tattt

tttgg

taat

tgttt

ctga

gttta

gaga

ttcag

ggga

agag

taat

cctc

tattt

gtgg

gctc

ttctta

gcat

ccct

aacc

ccca

agga

gata

gtac

atgg

ttttg

acttg

gtta

tttca

ctcc

tgca

ttcttt

ttccc

cca

aattt

taag

ttggg

tcac

attg

tgct

ggct

gcaa

aa

1426

3332349

—NO

gggg

atgt

ctgc

aatg

tcag

cact

gattg

cagc

acca

aact

caaa

gaca

atac

cact

catg

ccac

tgcc

aaca

tacc

cctg

gcttc

ctca

acaa

cttta

gaat

tatta

tattg

ccct

aagt

gcat

ctag

aata

1427

2416733

—NO

ggaa

aagt

acat

gcca

gaag

tcag

ctgt

gcag

taac

ctat

gaga

gagc

tact

cctg

tttca

cccc

agat

catc

acct

cgat

tcca

aag

1428

2437457

ASHlL

YES

aagc

acca

gttg

agat

tccc

agtc

cttc

tgaa

accc

cagc

taaa

ccttc

tgaa

cctg

aaag

tacc

ttgca

gcct

gtgc

tttct

ctca

tccc

aagg

ga1429

2704212

—NO

gaga

ttgat

gtgg

ttgtc

agct

aaac

ctgc

tcttt

cagt

agtg

gaaa

tt1430

3888795

—NO

gttg

tttgc

cttg

acag

tgcg

gctg

cgct

tcgg

cctg

ctcg

ggtta

ccag

ggaa

caag

gc1431

2556326

—NO

ttgcc

tcag

ctga

cttta

ccaa

aaat

tccc

tttcc

cttc

cctg

cttta

agtc

atttc

atgt

aggt

tagt

cttc

attta

ttcttt

tgcc

tctc

taca

gtag

ttattg

ctttg

tgc

tgta

cattt

gggt

taaa

ggag

ttgta

tatg

tgta

tggt

gaca

gcat

aatg

cctc

tgaa

gccc

agga

ccta

gcta

cttc

ttagc

tcct

aacg

taat

ttcat

ccat

g

1432

2878702

—NO

gtca

gagt

gtat

aagg

tgaa

atgc

cgttc

tgttt

ttgga

g

1433

3328538

—NO

gcca

tccg

gatg

tcag

ctct

gtgg

acat

tgac

tgct

ggttt

tcct

gggg

cctc

ggttt

tcct

ctct

ggcc

tggc

atgg

actg

cctc

ttgcc

ttgga

gttg

ctgg

gat

ggtg

gggt

gtgt

gtgt

gagt

gaga

gtgt

gttg

ttggg

gggc

agtg

ccct

ggag

agga

cttc

atag

cct

1434

3496801

NO

agga

ctgt

gtgg

cgga

ctat

gcag

cata

gt1435

3668198

—NO

tcca

cagg

gcag

aaac

tattg

caga

gttc

ac1436

3764547

4-Sep

YES

agca

gtat

ttccg

agac

gaga

gtgg

cctg

aacc

gaaa

gaac

atcc

aaga

caac

aggg

tgca

ctgc

tgcc

tgta

cttc

a1437

2544277

ITSN2

YES

ggag

tgct

agca

agtc

tgga

gcat

caaa

taaa

1438

2581567

___

NO

agca

gtttg

gcag

ccac

atgg

attg

a1439

2612556

___

NO

gcct

gggg

gaat

ccgt

gaac

gcct

a1440

2894809

SYCP2

YES

ggtg

tattc

atttc

cgtg

tattg

ctgc

tttL

1441

3956007

___

NO

gaca

gtct

tcag

aaaa

gggc

agct

gg1442

2407214

GNL2

YES

gaaa

caca

cgtg

tgat

taag

cagt

catc

atta

caaa

aattt

caag

agga

aatg

gata

cagt

tatg

aagg

atcc

atac

aaag

ttgtc

atga

agca

aagc

aagt

tac

caat

gtct

cttc

tcca

tgat

cgaa

tccg

gcct

cat

1443

2948537

KIAA19

NO

tcttt

ctca

catc

ctag

agac

ggtc

tttaa

tacg

catta

accc

tgtg

ctgc

caca

tctg

gctc

ctgc

cctc

attg

cctc

caat

ccgg

actc

ttcct

ctca

catc

a49

°1444

3991159

___

NO

acag

gtgg

actg

cagg

gtcg

tctta

caaa

atga

caag

1445

2444356

___

NO

taga

ccct

gaca

ttcag

ctcc

aata

atgg

atgt

ccca

gtat

gccc

tgaa

tcca

aaca

aatg

cctg

actg

caat

aa1446

2480997

MSH2

YES

agac

aggt

tgga

gttg

ggta

tgtg

gattc

cata

cag

1447

2671526

—NO

atgt

tcct

tcca

aatc

tcac

attg

aaat

gtaa

tcttc

tatg

ttgga

ggtg

ggcc

tgttg

ggag

gtga

ctgg

atcg

tggg

ggta

gattt

ctca

tgaa

tggc

ttatc

gtca

tcct

cttg

gttc

tgtc

cttg

tgat

agtg

agttc

tcgt

gaga

tcat

gttg

tttaa

aagt

gtgt

ggta

tccc

tctg

ccttg

ctct

tg

1448

2673140

—NO

aaga

ccac

attg

agcc

acct

atct

ccat

ctgt

gctta

tgta

ctct

gcttc

cttc

ttgtta

ggat

gaac

aatg

ggcg

aacc

ttcca

agttc

ctat

ttaaa

gtta

cccc

aatc

tgtg

caga

agat

cctg

tctc

ctcc

cacc

tact

caag

gcat

tact

ctgg

ca

1449

3394422

THYl

YES

catg

aagg

tcct

ctac

ttatc

cgcc

ttcac

tagc

aagg

acga

gggc

acct

acac

g1450

2485881

___

NO

gggg

tgac

attc

agat

tcaa

tcgg

tcta

cgga

tgag

aaa

1451

2572007

NO

aggc

ttcttt

gaca

atcg

tttct

gatc

tttag

ctga

gtct

agat

ggta

aaag

tgaa

ctag

tgaa

aggg

aaga

atga

gtttt

gtttt

ggat

ggca

tctc

atta

tttttt

atttt

ctttt

tattt

atat

atttg

tttttc

ttattt

tttttt

ctttt

tgat

tttaa

tacc

tcca

ccct

actta

caga

tattt

tttat

tttct

tgac

aact

ctga

taaa

tgat

ggat

tgga

ggat

caga

cttg

ttgac

atca

ctga

tgag

gcttg

tcttg

ttgct

tgtc

ttctc

tggc

taac

attc

ctta

gtaa

aaat

atttc

tata

tttttt

tcttt

atttt

atttg

gtca

ttattt

cat

tttga

gcttt

tttca

tttat

tact

agat

aagc

gagt

tttga

gtgt

caaa

tttgc

actta

atttg

tttttg

gtac

tgtc

ataa

ggac

tgta

gcat

acac

agca

tact

aca

actg

taac

ttttta

cgaa

aata

taca

tttttt

gaag

atga

cttc

agaa

actg

aggg

agag

agac

ccac

ttgag

acta

ggca

gcaa

acag

tgaa

gaag

aaat

gagc

aaca

tggt

gtgc

agga

gcaa

agttt

ccta

ctgt

atat

ctct

actc

taag

tgta

caat

gcct

a

1452

2804366

—NO

gata

cttc

atct

agta

attc

ctgc

ccag

gtttt

gaaa

cctc

atgc

tgga

ccct

cctg

tgca

aggc

tgcc

ctgc

tcat

tctg

ctct

catc

tgat

cctc

tcac

tggg

ccag

tc

1453

2369480

FAM20

NO

tcgg

caat

tgct

cattc

tagg

gttg

ggca

tcat

agttg

gtca

gtct

taat

tccc

atgc

caaa

ggac

aaac

aggt

gtga

cattt

ggat

agat

gaat

actg

ggat

tgB

gctc

tgga

gcat

gtgt

tttga

gttg

aacc

ttgca

gtcc

tttct

ctac

gccc

gtgg

atttt

gtgg

aaac

a1454

2556336

...

NO

agtc

ctgt

ctag

tggt

cagt

ccta

acag

tgtg

gtta

aagg

ggag

ctaa

atttc

aact

ttcag

gggt

cagc

tgag

acaa

ccac

ctag

atttt

ccaa

gtta

gttc

caat

ttcaa

gtac

aata

atcc

tttga

caac

atag

aaaa

gaat

tata

gtta

gcaa

aattg

caat

tgtc

acag

tcaa

ggtc

ttgttg

gtaa

taga

gggt

tggg

gaaa

aagt

taaa

acag

catta

aatg

aata

tattt

ttaac

ataa

caaa

agttc

ccag

aaga

catc

cact

tcaa

attc

aagc

cata

ttcat

caat

gtta

aaaa

cctta

ctct

tctc

cctg

atag

tgtg

agga

aaa

1455

2589618

TTN

YE

Scc

tatc

cctg

taaa

gcct

gtcc

caga

ag1456

3405368

—N

Oct

gggg

cata

aaaa

agca

agtg

ttctc

actg

aggg

atga

atag

tcta

ctag

caac

tgta

agac

agttg

cacg

aata

atga

tgat

acaa

agag

gtat

ccga

tgaa

tata

atgt

agca

ggat

aaac

aaaa

tggc

agtg

gaaa

acag

gagt

aaaa

ccaa

aggg

aagg

attc

tgag

aaga

ctat

ttata

atgg

gaac

taaa

attg

tca

gctg

aagc

tcag

atgg

cggt

agag

gcat

tcca

gatg

gagt

atag

aaaa

tgaa

tgaa

gacc

aagg

acag

gaca

gaaa

tatc

tggg

gtgc

actc

acta

ggt

gagt

gtgt

ccag

acat

tgaa

agag

gatg

agca

gagg

aaga

gaac

agga

gagg

taag

aact

aaaa

aggt

ggta

ttagg

tcct

ggaa

ggtc

ttaaa

tatc

aagc

taaa

gagt

tttac

tgcc

aagc

taca

gaac

tttat

caaa

tgcc

atac

tgag

aaga

ctga

tcga

tttat

taaa

gcaa

actc

ctaa

agga

tctc

ttcttg

gaaa

caat

tcat

tagt

ggtta

gtgt

ggaa

tctc

agtg

tggc

acgg

aata

aagt

aaag

taca

tggg

taac

ggcc

ccag

aaaa

acca

gagc

acag

ccca

gcgc

atta

ccac

tcat

cgcc

tggg

tgat

cttg

1457

3447472

—NO

tttta

agga

gggt

tgca

gaaa

gtga

1458

2331932

—NO

tgcc

ggtg

cagt

tcct

tggt

atac

tga

1459

2413973

USP24

YES

tacg

tcga

tgga

gttc

agca

caag

cacg

agaa

tttgg

gaat

cttc

acaa

taca

gtgg

cgtta

cttg

ttttg

c1460

2972147

—NO

aagt

cagg

aggg

ttcag

tgac

caga

1461

3568132

—NO

ttagg

tattt

cgag

tttga

agtg

tcta

taag

tcat

ctgg

agct

gtcc

agga

gatg

gttc

tata

catg

aaga

tcag

gacc

agttt

cttg

tcat

ca1462

3593984

—NO

ccag

gtgg

tcta

gcgc

tcct

aaca

aaca

cctta

tgat

tatc

cttc

attc

aaca

gagg

agga

gact

gcag

gcat

gcttc

agtc

agtg

gtaa

gaac

agga

agaa

aaac

ccaa

atca

gcaa

cattt

tcttc

ctta

atttg

gtat

aaac

gtcc

ttttc

atta

tttca

agtta

ctaa

tttgc

taat

ctca

aatg

ttttc

tgaa

tcag

gtttg

ctaa

atg

ctgt

aaag

aata

gcta

tcct

tcat

acaa

tact

aggt

tttat

tttttt

tagt

atgt

cagc

ataa

taag

gtac

atgc

gcat

tcat

tcca

ccaa

cctg

tttag

ataa

tact

cagc

ttggg

tcat

attc

aaat

tcta

caca

gaga

ttctc

tgttt

tcaa

taca

actg

ctta

gaaa

gcag

aattg

ccta

gtga

tgac

tgta

1463

3878647

NO

gcag

ccca

tccc

gaag

tgct

tatta

catta

gaac

attta

gtgc

tttta

aaga

tggt

gtgt

gtgt

gtgt

gtgt

gtgt

gtgt

gcgt

gcgt

gtgt

gtgt

gtgt

gaga

gaga

gaga

aagc

atat

ctaa

atgt

tggt

acca

aatc

atac

ccca

ttgga

aaga

ttcaa

ttttc

tgaa

attc

cacc

taag

aattt

ttgta

tgta

tata

tgaa

ggca

attg

tga

aatta

taga

gaat

tagc

aaag

tttat

ttaga

atttg

aggg

gtttg

gagt

gcag

tttta

caga

ttttc

tgac

tctc

ttttc

tttaa

tgtc

catg

caga

gact

aaca

taat

tgac

tttta

gatc

tttat

ccag

agag

tcaa

tcca

attc

aattc

aaaa

atgt

ttattg

ccag

tcca

ctct

gaac

a

1464

3271123

NO

gtga

gtcc

ctgg

gtca

gtga

gcac

a

1465

3291

284

TM

EM

2N

Oga

aagt

ggct

tattt

gagg

ttgttg

gtgc

tgttg

gtat

tattg

ccat

agttg

ttattt

aattg

cttg

atta

aact

cagt

caaa

tatc

cttc

cta

614

6638

5978

1D

MK

NN

Oca

agga

gcca

ccag

attg

gatg

ggag

cccc

caca

ctcc

ctcc

ttaaa

acac

cacc

ctct

catc

acta

atct

cagc

ccttg

ccct

tgaa

ataa

acct

tagc

tgc

c

1467

2326

309

—N

Occ

ttcac

ggat

ttggt

tggg

gtca

gaga

ga14

6830

9104

0B

NIP

3LN

Oag

tgca

ttgtg

ctct

ttcca

agttc

agca

gcag

ttcta

tcag

tggt

gcca

ctga

aact

gggt

atat

ttatg

atttc

tttca

gcgt

taaa

aaga

aaca

tagt

gttg

ccct

ttttc

ttaaa

gcat

cagt

gaaa

ttatg

gaaa

atta

ctta

aaac

gtga

atac

atca

tcac

agta

gaat

ttatta

tgag

agca

tgta

gtat

gtat

ctgt

agcc

ctaa

cac

atgg

gatg

aacg

tttta

ctgc

tac

1469

3823

592

HSH

2DN

Ogg

ggtg

cttc

atgt

cata

gcttc

tcag

aaag

cagc

agta

actg

aggc

tgtg

gatc

tgag

aacg

ggag

ctgc

tagc

caag

caat

gagt

gaag

ctttt

gtcc

gtag

tggc

atgt

tttat

ctga

ggcc

agcc

tttgt

actc

ctgt

gtta

1470

3551

323

CC

NK

YE

Sct

acac

caca

agtg

ccgc

aagt

acag

cagt

caca

gccg

tctc

aaag

ctcc

gaac

catc

ccag

ccc

1471

3602

745

RC

N2

YE

Sat

ggat

ttgtta

gtttg

gaag

aatt

1472

2332

284

NO

cccg

gcgc

gtat

cgta

ggca

gtgt

accg

tggc

cgtg

ccgt

caga

gtgt

gcgt

gtgc

gtgt

gtgc

cgtg

tcga

ggct

gtgt

ag14

7326

8989

1—

NO

ctag

aact

atat

tagc

tgct

cagt

gagt

tggg

caat

tgga

tattt

ttggt

tttat

gattt

caga

tttta

taga

ccag

tgga

atac

aggc

cttg

tgca

tatg

aaga

tca

ggtg

acaa

gtttg

c

1474

2952

713

NO

tgttt

gttg

tttgg

ttatg

atct

tgct

t14

7531

8128

9T

MO

Dl

NO

cggt

ggag

tcca

tgcc

tttga

actg

gatg

tgttc

tattg

atga

cctg

tgct

ctgc

aggg

gaaa

ccag

aagg

caaa

atgc

tggc

agca

tgaa

accc

ttttg

tgg

ttcag

ttcttt

atgc

acta

aggt

tttag

gttg

acta

gtgg

ttgta

gttg

aaaa

tttta

taaa

atac

cgtta

atgt

gaag

tttttc

tttag

tcac

agaa

gttg

aatc

tggt

tat

tattt

aaaa

acta

gaag

cccc

caaa

ccag

caga

tctta

ctga

agat

gatg

ttcca

gcag

cagc

gact

tagc

ccca

ggag

ccca

gtttc

aatg

gcct

tgct

gtg

tggt

gtttc

aagt

gcat

ttaaa

atgt

gtga

caca

gaaa

cggc

acac

tcttc

1476

3412

443

—N

Oac

ctttg

acat

ctct

agca

cacg

gagc

aattc

taga

tggt

tgat

aaaa

gagc

ataa

atca

atcg

acac

aaat

atcc

cctta

aacc

ttgtc

tttca

tgtc

cagt

att

1477

3886

313

TO

X2

YE

Sat

gagt

gacg

gaaa

ccca

gagc

tcct

gtca

acca

gcca

g14

7839

7655

7R

BM

3N

Oat

ggga

cgttt

gtag

aacc

tgag

tattt

ttcttt

ttacc

agttt

tttag

tttga

gctc

ttagg

tttat

tgga

gcta

gcaa

taat

tggt

tctg

gcaa

gtttg

gcca

gact

gac

ttcaa

aaaa

ttaat

gtgt

atcc

aggg

acat

tttaa

aaac

ctgt

acac

agtg

tttat

tgtg

gtta

ggaa

gcaa

tttcc

caat

gtac

ctat

aaga

aatg

tgca

tcaa

gcca

gcct

gacc

aaca

tggt

gaaa

cccc

atct

gtac

taaa

cata

aaaa

aatta

gcct

ggca

tggt

ggtg

tacg

cctg

taat

ccca

gtga

cttg

ggag

gctg

agg

cagg

agaa

tcgc

ttgaa

cccg

ggag

gcgg

aggt

tgca

gtga

gcta

agat

cgcg

ccac

tgta

ctcc

agcc

tggg

caac

agcg

agac

tcca

tctc

aaa

aaaa

aagg

aaat

gtgt

atca

agaa

catg

atta

tcca

gcgg

tattt

tcta

attc

agat

catc

aaac

tgat

tata

taga

agag

ttggc

tttaa

aatg

tttgc

aaat

gtc

tttttt

ttttta

atac

tgga

agaa

aaaa

tattc

tgttg

tgtc

tcat

acag

tgct

tagg

atgt

ctttc

1479

2635

686

PVR

L3

NO

ttcca

tagc

tgta

gctg

gagc

ggta

attg

gagc

tgttc

ttgcc

ctttt

catc

attg

ctat

ctttg

tgac

tgtg

ctgc

tgac

tcct

cgaa

aaaa

aaga

ccat

ccta

tct

tgac

aaag

t

1480

2680971

—NO

agttg

gctta

caac

ctgt

gctg

tattg

a1481

2715956

HTT

YES

ttgag

ttgta

cagc

cgct

ggat

cctg

ccgt

ccag

ctca

gcca

ggag

gacc

ccgg

ccat

cctg

atca

gtga

ggtg

g1482

2452913

__

NO

ctgt

gcac

agga

ctcc

tcaa

atat

tttcc

gtt

1483

2667796

—NO

caag

agaa

ggtg

agca

tata

acag

gtaa

ataa

caga

agct

ctga

tttttt

ttttc

ttttta

tagt

ttggg

acta

ttcat

ccag

caag

agaa

ggac

gctta

aaag

taga

tt1484

3602153

C15orf3

NO

aagg

gattc

tgat

gagc

cgat

gggc

cctg

gagg

cagc

ccat

taaa

gcat

ctgg

o y

1485

3752031

CRLF3

YES

tacc

aaaa

aggc

ctcg

caca

ttcag

ttgga

cag

1486

3765307

APPBP2

YES

ggaa

actg

aaca

gagg

ctgc

ttcaa

gaag

ctca

tgat

ttgca

cctg

tcttc

actc

caac

tagc

taaa

aaag

ctttt

gggg

aattt

aatg

taca

gact

gcaa

aac

acta

tgga

aacc

ttgga

agac

tt1487

3956644

NO

gtac

atgc

aaac

ggga

tggg

agca

g1488

2345202

NO

tgat

gccc

gcgt

tgtc

ttttc

agac

tctg

tttttt

gcct

ttagc

atgc

cttg

taat

tttttt

tttttt

ttttg

ataa

gctg

gatg

tgac

ataa

gggg

taaa

aaga

actg

aga

taaa

cagg

ccttt

agtg

tggc

ctag

aggc

ctat

ctgg

ctag

gagt

tagg

ctgt

gttta

ctgt

ttgat

gtag

ctttg

gtgt

caga

gatta

aaat

ttcct

ctcg

tgta

act

gcttt

tgtc

tcct

ttgttg

tcttt

gggt

ttccc

taat

aact

ccttc

ataa

gtag

gttc

cgag

gcttg

tagt

tattt

aagc

tgta

agtc

cctg

ttatta

caca

ggag

ccct

attg

atgt

ggtg

tgtg

tgtg

tgta

aaag

tgttc

tata

atct

tatg

atta

gctc

ttagt

gagc

ctgt

gtct

ttgga

ctgt

gacc

ttcat

gagt

gcttt

ttagc

1489

2655521

ABCF3

YES

aaag

gaga

gtcg

gttg

gaat

catc

tggc

aaga

acaa

1490

2920283

...

NO

gcag

gaca

tacg

ctaa

aacc

ggag

caat

acag

agaa

gatta

gcat

ggcc

ctca

ccca

aaga

tgac

acgc

1491

3102056

...

NO

agat

taca

aact

caca

tttaa

tgtta

taaa

tgca

gaaa

aagg

ccaa

aaac

acaa

aaag

agtg

gcaa

cgag

ggac

ag1492

3161310

—NO

tgaa

gacc

ttcac

gcttt

ctct

gtaa

gtttt

cattc

aaaa

catc

tttca

atttc

tttttt

ttcttt

ttcttc

tttttt

gccc

tcat

tttag

ttagt

ttgag

tttct

tgtg

gctc

tgta

gtga

ctgc

tcta

atag

aata

tccc

ttaca

acttt

gtgg

cagt

taat

ttctg

gatg

atca

ctgt

gact

tcca

tttac

atgt

atttg

g

1493

3289083

NO

acag

gtaa

atta

ggac

ggca

ctgc

gggt

actc

tgtg

ttccg

cctg

ctca

agttc

taga

cttc

tggt

gtcc

atag

caac

ccag

caga

1494

3304760

-..

NO

cggg

gagg

aaag

acag

ctct

acca

g1495

3895434

C20orfl

YES

tcttt

cctg

ggca

ctta

tcta

acag

94

1496

3406522

—NO

tggt

tttgt

ggat

aggg

gaaa

tcta

gtag

atat

taaa

tattt

ttatc

tgca

aaaa

gcat

ttggt

aagg

ttctc

aatg

ggag

atta

atga

ctaa

aata

aaga

atga

ggca

ttagg

agat

aaat

ttgct

tatg

agca

agag

acag

atac

taac

agta

gaag

gaaa

tact

tttta

gattg

gaaa

ggag

tgac

atat

agca

caag

ccag

gaat

cag

ttttg

ggac

cta

1497

2692051

NO

gtat

cgga

ttaag

ctca

aaac

ggga

ggag

gaaa

caag

gatg

actg

gagt

caag

gaa

1498

2835105

LOC728

NO

ggca

gggg

ttggg

acaa

gtgc

taag

tatg

caag

actc

aagg

gaag

agct

264

1499

3935012

N NO O

cftc

tcca

øffc

caga

tttaa

ccac

ataa

acac

atca

aatc

ccap

ct

1500

4038282

—NO

tggc

tggg

tgag

ttcta

aaaa

tgcc

caag

acct

ccaa

gact

aggt

gaga

tctg

aagt

aatg

aaat

gcct

ccat

tcac

taaa

ggcc

tgaa

attg

tcct

gact

gcct

cag

1501

2856770

—NO

atgt

tcaa

ccag

atga

tggg

ccat

gattg

t1502

3579731

—NO

ccca

tgtg

tatg

ctttg

agcc

gttc

ctta

gttg

agta

ggtg

attg

acca

tacc

agca

gcac

tggt

gcca

atta

agcg

gtct

gcttg

gttc

acac

agcc

tttca

ttcct

gttc

tagc

atgg

ctct

gtct

taaa

tctg

catg

catg

tattt

attc

ctta

atat

atta

cctc

tcttc

ctttc

ttcct

tttta

cattt

cttc

ccat

ttttta

ttgttt

ctct

ctct

ctca

ctct

ctca

ctca

ttctc

tcttg

cact

ttgtc

ttcgg

agct

cattg

ccat

ggag

tggc

ttggc

tgta

cgca

tcaa

aaag

ccac

ccgc

aaac

gtcc

atcc

ttggc

cgtg

cggt

tcca

cgtc

tcac

tcat

tact

tcct

tcct

gcat

tcat

agca

tcct

tcct

tcct

gcttg

ctct

ctttt

tatta

ggca

tttat

tcct

ctat

tagt

ggag

tcag

gtg

ccct

tatg

acaa

gtcc

tagc

1503

3636549

—NO

ctac

tgaa

agca

tgtc

ctgt

gaat

gtta

cttg

tcag

tgac

aaaa

tagg

taca

gaaa

ttgaa

ataa

gagt

ttaga

aattt

ttaga

gccg

tttga

tgga

gtag

ctttg

tga

atct

aata

attg

aggc

ttaca

ttttg

tatg

tcttt

atttt

tctc

ataa

tttat

tttta

tttta

taaa

catg

tctg

tttgc

aact

catta

gaac

tttaa

aaaa

aaaa

acta

gtca

ttcac

tcta

ggta

gagt

agaa

gtac

tgac

tatg

aagg

atct

ttaaa

ggtc

aata

gtgg

tcct

aata

cgta

aaat

aattt

gctc

atat

ggtg

tattt

aaac

tattg

gcaa

ctat

gtaa

aagg

ggga

atgg

gttg

acct

tcat

gtta

caaa

tatta

atttc

tcct

gcat

aaaa

gtac

cctc

attg

1504

3653150

—NO

tttca

tgag

atct

acac

ctgg

gctg

ggca

cgcc

tgttg

gtttt

ttact

gaca

acgc

ataa

tttttc

gagg

agtg

gtaa

tcag

aggc

aacc

gttc

tagt

gaca

gtg

attc

aggc

gtaa

acac

ttggc

tttgg

ccca

gagg

ttgca

ctgt

gtga

gacc

acag

gtga

acac

taga

atgt

ttaca

ctct

tccg

gagt

ctgt

aggt

ggat

gcc

a1505

4011856

IL2RG

NO

cagg

gtcc

tgta

gccc

taag

tggt

acta

acttt

ccttc

attc

aacc

cacc

tgcg

tctc

atac

tcac

ctca

cccc

actg

tggc

tgat

ttgga

atttt

gtgc

cccc

atgt

aagc

accc

cttc

atttg

gcat

tccc

cact

tgag

aatta

ccct

tttgc

cccg

aaca

tgttt

ttcttc

tccc

tcag

tctg

gccc

ttcct

tttcg

cagg

attc

ttcct

ccct

ccct

ctttc

cctc

ccttc

ctct

ttcca

tcta

ccct

ccga

ttgttc

ctga

accg

atga

gaaa

taaa

gtt

1506

2351151

—NO

aaat

agct

gggt

ctca

gtgt

ctct

tt1507

2577491

—NO

gttc

tccc

tagt

tttct

ctac

aaca

gtgg

aaaa

caaa

gcag

tgct

ctct

atgc

cagg

acag

taca

tttgg

acgg

cgac

acct

tgttt

gcag

aatc

ct1508

2693258

—NO

atct

acat

tttca

cact

gaca

ccca

1509

3156385

—NO

agtc

acac

ccttg

ggga

tctc

attg

tgttt

catg

actta

atta

tgct

gctg

actc

tcag

attg

ttatc

ttagt

ttttc

agac

ttcttt

cttg

aact

ccag

accc

gtgg

ccac

tatg

ttctc

gcca

tgtg

gaat

ctga

tgtc

tcat

aagc

atttc

agac

ttaat

atac

tcaa

aagg

aact

gata

ttcac

gcca

agcc

tgct

tctc

tccc

cttc

tcca

ctca

ctaa

atgg

cact

acttt

ccttc

tggc

tgg

1510

3175668

VPS13A

YES

cttg

gagg

tatta

tagc

agaa

gtga

atttg

gccg

agca

ttcta

cagt

tatta

cattt

ttaga

ttatc

atga

tgga

gcag

ctac

attc

ctct

taat

aaat

caca

caaa

gaat

gaac

ttgttc

1511

2389740

NO

atga

gtga

ttcat

tctg

ccct

gtgg

acac

ttggg

aaca

gaag

gcga

ctct

tgag

ctgg

gtttt

ccag

gctta

ttagg

cgct

cagt

gggt

taac

agaa

tgag

ctg

gtcc

agga

agag

atca

gcct

gtga

aagc

cgtg

gctg

ggat

atta

ttgga

gat

1512

3224

499

NO

atct

ctta

ggtc

atat

gtca

tcgc

atta

ccttt

aaaa

attg

tatg

gtct

aaat

gtaa

aata

gtta

tttttc

aaca

tttgt

tttaa

tacc

cttg

taac

tgct

tttta

ctca

aga

caga

cattt

cact

taca

ctaa

gtgt

gtgt

gtgt

gtgt

gtgt

gtgt

gtag

aaac

ttagg

atat

aaca

cgta

tgta

aatta

caca

caca

tacc

tgttt

aaat

gtaa

gaa

ttcag

tgat

agga

acag

ttcat

ctaa

gaag

atttt

aatg

acag

ggca

ctct

tttgg

ccaa

agca

gtgg

aattt

ccta

agca

gcaa

ggttg

gtaa

tagt

gctg

gta

ggat

ctgt

atgt

gtaa

gctg

ttaca

caag

ctga

ggat

caaa

gtgc

caat

ttctc

aagg

agaa

aaac

ttctc

cgag

aaat

gaaa

gtct

ctga

tctg

tgttg

tatg

ccc

taa

1513

2807

754

C7

NO

gggc

caga

acac

actc

taca

aaat

gact

agga

taac

agaa

agaa

cgtg

atct

cctg

atta

gaga

gggt

ggttt

tcct

caat

ggaa

ccaa

atat

aaag

agga

cttg

aaca

aaaa

tgac

agat

acaa

acta

tttct

atcc

tgag

tagt

aatc

tcac

acttc

atcc

tata

gagt

caac

cacc

acag

atag

gaat

tcct

tattc

tttttt

taat

tttttt

aaga

caga

gtct

cact

ttgttg

ccca

ggct

ggag

cgca

gtgg

ggtg

atct

catc

tccc

tgca

acct

ccgc

ctcc

tggg

ttcaa

gcga

ttcttg

tgcc

tcag

cttc

ccaa

gcag

ctgg

gatta

cagg

tgcc

cgcc

acca

cgcc

cagc

taat

ttttg

cattt

ttagt

agag

atgg

ggttt

cacc

atgt

tggc

cacg

ctcg

tctc

caa

ctcc

tgac

ctca

ggta

atcc

gcct

gcct

tggc

ctcc

caaa

gtgc

tggg

atta

caga

catg

aacc

acca

cgcc

tggc

tgga

atac

ttact

cttg

tcgg

gag

attg

aacc

acta

aaat

gtta

gagc

agaa

ttcat

tatg

ctgt

ggtc

acag

gggt

gtct

tgtc

tgag

aaca

aata

caat

tcag

tcttc

tcttt

gggg

tttta

gtat

gtgt

caaa

cata

ggac

tgga

agttt

gccc

ctgt

tcttt

tttct

tttga

aaga

acat

cagt

tcat

gcct

gagg

catg

agtg

actg

tgca

tttga

gaat

agttt

tccc

tattc

tgt

ggat

acag

tccc

agag

ttttc

aggg

agta

caca

ggta

gatta

gtttg

aagc

attg

acct

tttat

ttattc

ctta

tttct

ctttc

atca

aaac

aaaa

cagc

agct

gtgg

gagg

agaa

atga

gagg

gctta

aatg

aaat

ttaaa

ataa

gcta

tatta

taca

aata

ctat

ctct

gtat

tgttc

tgac

cctg

gtaa

1514

3929

304

C21

orf5

NO

tcca

caca

gtga

gagt

ccag

ggct

cagg

gctg

ctca

agac

caag

gcttc

ccttg

atgc

ttcac

ttcgg

gtga

tcag

acat

gggg

gacc

tgttt

atct

ttagt

aQ

gccg

gcaa

aggc

aatc

gtaa

aaca

tttgt

tgta

acttc

agga

ttgtc

actc

taag

aaca

cc

1515

3947

636

TSP

OY

ES

gtac

ggct

ccta

cctg

gtct

ggaa

a15

1627

4823

4N

Ocg

aggt

ttatg

ttgtg

ttagg

ctca

tgag

aagg

caag

aaat

tttat

tattt

aaat

gtttt

ctcc

agta

atgt

attg

gattc

aagc

cattg

agat

ttggg

gagt

gtttc

agt

gact

tattt

gggc

aaaa

caga

atat

ttgaa

attg

gcat

tgtc

tcag

aatc

tggc

1517

3630

746

ITG

AIl

NO

gact

gtaa

atac

gaac

ccaa

tctg

caca

ctcc

aggc

ctct

agttc

caga

agga

tcca

agac

aaaa

caga

tctg

aattc

tgcc

ctttt

ctct

cacc

catc

ccac

ccc

tcca

ttggc

tccc

aagt

caca

ccca

ctcc

cttc

ccca

taga

tagg

cccc

tggg

gctc

ccga

agaa

tgaa

ccca

agag

caag

ggct

tgat

ggtg

acag

ctgc

aagc

cagg

gatg

aaga

aaga

ctct

gaga

tgtg

gaga

ctga

tggc

cagg

caag

tggg

acca

ggat

actg

gacg

ctgt

cctg

agat

gaga

ggta

gccg

ggct

ctgc

accc

acgt

gcat

tcac

attg

accg

caac

tc

1518

3004

500

—N

Oct

catg

cttc

aaag

gcat

attc

tcaa

gaaa

cagg

tgta

atttg

tgca

gata

atca

cacc

tggg

aagg

gatc

acag

agaa

ggag

aaaa

agaa

agaa

atgg

ctta

ttctg

aggt

gaat

gtgt

c

1519

3552

925

DY

NC

lY

ES

tgcc

acct

tgat

gacg

cagt

gcaa

agag

gggg

caca

gaag

gaag

gcct

gatg

ctgg

actc

gcac

gagg

agct

ctac

aagt

ggttc

acta

gcca

ggtta

tH

lcc

gcaa

cctc

cacg

tcgt

gttc

acca

tgaa

cccg

tcct

cgga

ggga

ctca

agga

ccgg

gcag

ctac

atca

cc

1520

3649

810

—N

Oca

gcaa

gagg

tgca

ggttg

agta

tttgg

aggt

ggta

tattt

ggcc

agac

tttag

ccgc

atcg

atta

tgct

atttc

ttgct

ggct

gtttt

aaat

tttttt

taaa

aagg

agg

aggt

gtca

gata

catc

atttc

a

1521

2782

685

NO

aaaa

ctag

ggct

gtcc

aggc

ttaca

1522

3166121

NO

caaa

agcc

tgct

gctg

ggta

gata

g1523

2524769

NO

agtg

tagt

gcag

cattg

cctc

tgga

actg

gcct

gattc

ttgcc

tcat

aaaa

ttcttg

tgac

caat

aaat

gaaa

ttcta

caca

ttttta

tgtg

tcta

aaat

ccca

agac

tagt

atct

gaca

catg

gtta

gctc

tcaa

tata

tttta

gcta

ctgc

tatta

tcat

tattg

gtag

tact

atta

aaca

ttttg

aaac

agaa

aatc

acttg

gggc

tggt

cacg

gtgg

caca

cgcc

tgta

atcc

tagc

atgt

ggag

aggc

cgag

gcag

gtgg

atca

ctgg

agct

cagg

agttc

aaga

ccag

cctg

acca

aatg

gtaa

aatc

ctg

tctc

tacc

aaaa

aaat

acaa

aact

taga

tggg

cgtg

atgg

catg

cccc

tgta

gtcc

cagc

tact

caac

aggg

tggg

gtaa

a

1524

3101

675

AD

HFE

NO

ttaac

tgaa

agaa

ttacc

gctg

gcca

ttgta

gtgc

tgag

agca

agag

ctga

tcta

gcta

gggc

tttgt

ctttt

catc

tttgc

gcat

aact

tacc

tgtta

ccag

tata

1gg

tggg

atat

acat

ttatc

ttgca

ggaa

attc

ccca

aagc

tcag

agtc

cagt

tcct

tcca

taaa

acag

gctg

gaca

aatg

acca

ctat

gtta

gacc

ccca

ggc

tcga

cttc

aggg

gtca

gtgt

tcct

gtcc

caaa

cccc

acac

agaa

tact

ctgc

ctct

gtttc

atgt

agca

aatg

a

1525

3633

418

SIN

3AY

ES

cacc

tctc

acttg

cgta

tgaa

gaca

aaca

aata

ctgg

aaga

tgct

gctg

ctct

gatta

tcca

ccat

gtga

agag

gcag

acag

gcat

tcag

aagg

agga

caa

atat

aaga

taaa

acaa

atca

tgca

tcat

tttat

tcca

gattt

gctc

tttgc

ccaa

agag

gtga

tctc

tcag

atgt

ggag

gaag

agga

agaa

gaag

agat

ggat

gta

gatg

aagc

caca

gggg

cagt

taag

aagc

acaa

tggt

gttg

gggg

cagt

cccc

ctaa

gtcc

aagt

tact

gttta

gtaa

caca

gcag

ctca

aaaa

ttaag

agg

aatg

gatg

aagt

atac

aacc

tcttc

tatg

tcaa

caac

aact

ggta

tattt

ttatg

cgac

tgca

ccag

attc

tctg

cctg

aggc

tgct

acgg

atttg

ttccc

aag

ccga

acgg

caaa

ttgaa

gaag

aaaa

ccga

gaga

gaga

atgg

gaac

ggga

agtg

ctgg

gcat

aaag

cgag

acaa

gagt

gaca

gccc

tgcc

attc

agct

acgt

ctca

aaga

1526

3904

327

NO

ttcca

aagg

tcgc

taaa

gata

ctgt

tact

acta

ttgag

atat

tattg

gcta

cttc

acgt

ttaca

tagt

aaat

gtttg

cagc

atat

aaca

ttaca

gact

cata

aacc

cata

atta

actta

taag

tgtta

atgg

acaa

ctgt

gcttt

gattt

ttgcc

tttag

tgat

aaga

aaac

aaag

tagt

gaaa

tggg

tcac

tcct

caaa

gcat

ggaa

cattt

taa

ctttg

ccta

gtaa

ggaa

aaac

aaaa

caaa

atat

agca

atta

catg

tgga

accg

taac

ctgc

aaaa

gtaa

caca

aata

ttgtc

tcaa

aagg

taca

aata

ggttg

tac

ctgg

acct

taag

cagc

atg

1527

2652

509

FND

C3

YE

Sgc

acca

attg

acaa

cggt

tcaa

aaat

cacc

aact

acct

tttag

agtg

gB

1528

2441

680

—N

Oag

gcaa

gagc

ccttt

cgtg

caag

taag

caat

tttgc

tgcc

tccc

atttt

tttttt

tttttt

caat

ctgt

ttggg

acttt

gagg

gctg

gggt

ggga

aggt

agtg

gaat

gga

atag

ataa

acag

ccag

tcaa

gagc

tgtg

ggga

ggttg

acag

aattg

gggt

gcag

gtac

atgt

agga

taca

caga

agct

ttgtg

tctg

tgga

ggct

gtat

gagt

ctgt

gggt

gagc

agca

tgtc

taag

tggg

tgga

aa

1529

2694

895

NO

atgc

cttg

gaga

cgag

ccca

gaag

gag

1530

3048

170

C7o

rf44

NO

tcct

atca

tagc

tggc

accg

tgttc

atgc

ctgt

ggta

ttccc

tgta

tccc

tattc

ctgg

gaag

cagc

ccag

gagg

ggga

ttccc

ttggc

ctct

ccag

ggtc

agg

tcac

ctttc

ccttc

atta

gtgt

gatg

ggac

cttc

agaa

gaga

agca

ctttc

tgcg

gcca

aact

g

1531

3085

948

YE

Sga

ggcc

ggta

gtgc

tgaa

tgga

catg

gggc

tgga

tgaa

aaga

cttc

cgcc

tgcc

tctc

tcag

cccc

ggaa

tcgc

catg

agct

gcta

tt15

3233

0024

6C

PEB

3N

Ogg

ccttt

ccttg

gtgt

gaca

cttg

aact

agtc

gattt

tttga

aggc

tata

acct

aacc

tcga

ctat

ttgttg

ttatg

tgca

1533

3822

344

MG

C32

NO

ttgga

gaca

ccat

gtta

gtcg

tggc

tggt

ctcc

aact

cctg

acct

cggg

tgat

ccgc

gccc

cgcg

gcct

0715

3423

4552

0NNO

Oaa

gcct

gtttg

agag

cagg

actg

at

1535

2549493

—NO

gctc

cggc

cgag

agaa

gcca

ccat

tcct

ttc1536

2788417

ZNF827

YES

gaag

agtta

ctgg

aagc

ggca

catg

gtga

ttcac

acag

gttta

aaaa

gtca

tcag

tgtc

cgct

ctgt

ccat

tccg

gtgt

gctc

gcaa

ggac

aatc

tc1537

2544515

ADCY3

YES

acta

tgtg

acct

tcat

ggtg

gggg

ag1538

3329911

NDUFS

YES

ccac

tgtc

agac

cacg

gaat

gatg

tggc

ccac

aagc

agct

ctca

gcttt

tgga

gagt

atgt

ggct

gaaa

tcttg

ccca

a3

1539

3467685

—NO

cagg

gagc

tgca

tgtc

caac

tgttc

tcag

ggga

gaaa

gtttg

gcct

tctc

tagg

aaca

gacg

gaga

gaag

gcaa

ggga

tcct

aagg

gaga

tggt

gcaa

ggg

ctttt

gggg

agttt

gggg

tttat

ccaa

aatg

tagt

agag

aaga

gggt

tcttg

aaga

gtttt

cagc

aggg

atgg

gaca

tgtg

ggat

ttgtg

taaa

gcag

gga

gcaa

acta

tggc

tcaa

gggc

ctgc

tttgg

ctca

ctgc

ctgt

ttttg

gaaa

caaa

gtttt

attg

gatc

acag

acac

acca

ttagt

tttct

tagg

agct

acaa

aggc

1540

2535364

NO

atca

agga

agtc

gagt

aaaa

cact

tct

1541

2979944

SYNEl

YES

gcag

caaa

tagg

tgaa

agat

tgaa

tgaa

tggg

cagt

cttc

agtg

aaaa

gaac

aagg

aact

ctgt

gagt

ggttg

actc

aaa

1542

3210881

—NO

atgg

ctct

acag

cacc

ggat

tttgc

atca

gaat

ccct

tcga

gtttc

ttatc

ttcac

catc

tgta

gcat

ttaga

ttgaa

aagg

ctta

cctg

ggttt

tcttt

ttttg

tgttt

tat

gatc

tcaa

gcta

ttggg

agta

gacc

aattc

gtgt

ggct

caat

atga

gagt

taaa

gtta

cgtc

agaa

ggta

atga

aagc

tgat

tttgc

ccttt

tatta

acta

tagt

atttt

aatc

ctgg

tatg

taaa

atta

ttact

cattt

gtgc

ctaa

tgca

gata

atgg

gaag

cagc

tcac

tgtg

gtaa

agta

gggg

catta

agca

cagg

tgca

ac

1543

3984493

NO

ccag

ggaa

atat

ggga

actg

tgag

aggc

agca

ggca

agtta

tggg

caga

ggca

gata

caat

gagt

tcat

gtgg

gaaa

ttt1544

3294206

...

NO

tttttt

ctgc

actc

ccat

tgct

tta1545

2389550

__-

NO

atgt

attg

gtgg

acag

catc

tagg

aaga

ga1546

2593736

—NO

gctg

taac

acttt

acta

tgtc

tatg

caaa

taca

cattt

aaac

aata

tagg

aaga

tttca

ataa

ccaa

acta

actg

taca

aaaa

ataa

acaa

atta

acttt

atta

catt

gcta

cttc

aact

tcag

tcct

taca

ttgat

ttgttt

tttaa

aaaa

tacc

agttt

gaaa

caca

ttact

gaaa

gtga

gtgt

acac

aata

aata

gaaa

atag

ggat

gcat

agt

gctg

gaga

cattc

aacc

aact

tatc

ttcat

ctgt

tgcc

tact

gttg

1547

3315642

ATHLl

YES

gaat

gcag

acgg

gtca

ggcg

ctgt

gaac

ttcct

1548

2638195

—NO

gtca

acga

gggg

aatc

cact

ctgc

c1549

3973655

—NO

cagt

ttggc

aaag

agca

tgcc

actg

ttcct

gctg

tcta

tcaa

ag1550

2409486

NO

tctg

aaat

ccga

catc

ccag

tgtc

cattc

tggg

gcac

agct

tccc

ctcc

tttca

agtc

tctc

tcttc

ctcc

ctct

ccac

aaca

caga

ggcc

tttag

ctcc

ccag

ccc

ttact

gttc

agtg

cgtc

cacc

cctc

cttg

tcta

gacc

ctga

agta

tatta

catc

agct

actc

tcttg

tgag

ctcc

tcca

gtac

tctg

cccc

ttgtc

cttc

tattg

ccct

agtc

tagg

1551

2635963

PHLDB

YES

cctg

cctg

tccg

gaag

gaag

acttt

gattt

gcgg

agcc

atgt

agag

actg

ctgg

ccac

aata

ttgac

acct

gtta

ccat

gtat

caat

caca

gaga

agac

ctgc

2cg

agga

ttcct

catc

aaaa

tggg

tggg

aaaa

ttaaa

acgt

ggaa

aaaa

cgttg

gtttg

tttttg

atcg

gaac

aagc

gaac

attc

tc

1552

3730508

TANC2

YES

tcca

caat

gttg

ctgc

cttg

ctct

gccg

ctca

cctc

agct

gaca

gcct

atcg

ggag

cagc

ttcttc

ggga

acct

cacc

tgca

gagc

atgc

tgag

ccttc

gttc

ctgt

gttc

a

1553

2512118

NO

ggca

tatg

tttgg

tatc

tctg

gtcc

ttagt

tcct

gaac

aattc

tggg

ctaa

tgct

gtag

tca

1554

3181032

—NO

tgct

tcta

acaa

atcc

gccc

tgtc

acat

gcat

atgc

tttct

caac

attc

actg

tcaa

aaat

gccc

tacc

agga

caca

acat

agtg

acaa

taac

acat

tcaa

tttaa

ggat

aatg

gttg

agag

ggaa

ccag

ctaa

gaac

ttaca

ata

1555

2401404

ASAP3

NO

aggc

ctct

ggat

ggca

gaag

gaaa

g1556

2496802

MAP4K

YYEESS

tgat

ctttg

gtct

tgtg

gcat

taca

gcca

ttgag

atgg

ca4

1557

3048180

___

NO

tcag

attta

ctttc

ccgg

agta

gtca

cagg

actg

ggca

gtga

1558

3436406

—NO

ctct

gtgc

ctta

tcag

gaga

gggt

gact

ctgt

gccg

acttt

acaa

ggct

atgg

gaag

gaca

c1559

3840203

LOC400

YYEESS

gctg

tcgt

agag

tggc

aatc

atca

gtgg

c713

1560

2633650

NIT2

YES

ctgg

ctga

aata

cgcc

agca

aatc

cccg

ttttta

gaca

gaag

cgat

caga

cctc

tatg

1561

2835873

—NO

tgat

caaa

tagt

gccg

tctg

cctg

gagt

acag

catg

gggg

aaga

ggttt

ggct

gtgt

tttga

tgta

gtca

ctgc

ccat

agtg

ttgta

gttg

cttc

atttt

gatg

tgt

cata

cagc

taaa

gatg

ctcc

cttta

ggtc

atttt

tgttg

ccgc

tgcc

tctg

cggc

ttgtta

ctac

tgtt

1562

2849540

NO

agaa

gaca

agag

gaag

ccgt

tctg

ctgg

cattt

cgtc

ggga

tgaa

gaca

acac

agcc

a1563

2986834

___

NO

ctgg

ccgt

gtttc

ctgt

gagt

tttga

gg1564

3222790

—NO

tgct

gttc

tgct

tctc

ccat

tcttg

cata

gagt

aatg

gagt

tagt

gaaa

atgg

gcttt

ctttt

acaa

caca

aagt

gttg

ctct

tcttt

ctcc

tagg

gaga

aagt

agta

agct

ctgt

gggt

gtag

gagg

agga

aaat

agca

ggag

ctta

gcca

agga

gggt

gctg

cagc

acat

gtgg

gtct

tcat

agtc

cgga

aggg

tgag

tgac

ac

1565

3317133

NO

ccaa

aagg

actg

tcgt

ggca

gagc

agcc

atgg

ccaa

gtgg

actc

aggg

ttcat

tttcg

gaac

ccct

ttaag

ctta

taga

aagt

cccc

atca

tcac

ccag

ctc

ggcc

ccgg

ggca

ccga

gtcc

gtct

ggtg

tggg

gcgt

ccttt

cgac

agag

cctc

ctcc

acaa

accc

agac

tctg

gcttc

cacc

aggg

cccc

ggac

acct

gct

tcct

cagg

gcag

acag

agag

gggt

gaca

cact

gcac

cctg

tggc

tggg

aaaa

gggg

cctg

ggac

tgtg

cccg

tctg

ggac

ggag

caga

gcca

cca

tccc

atgc

aggc

acta

tcac

cgca

ggca

aa

1566

3600340

—NO

aggg

ccac

tcaa

ccat

gcgc

tctg

ggag

gagt

gggc

tgag

atgg

ggct

gcttg

gtca

gccc

tgac

tgtg

ctttt

gatc

tttgg

gcgt

cacc

1567

3929187

—NO

ctgg

ccac

cagg

gaac

agtta

cgta

aatta

tttga

tgtg

tcttt

ttaac

aaga

tatta

ggaa

gtgc

tcgg

cattg

ttagg

atttt

ttttg

gcca

cgtg

gaaa

aaca

cac

atga

tata

aagc

aaag

gaaa

ataa

ggca

gtct

gcaa

atgg

atct

gctta

gaac

tgcc

atta

cgta

a

1568

3989061

—NO

cttg

ctct

gtca

tacc

ttgtg

gaaa

tgta

aaag

atca

atga

cagc

tagc

ctttt

caca

caat

tattt

atgc

ctcg

gccc

tcta

attg

acac

agtta

cccc

tagc

act

catc

gttg

tgat

cacc

tgca

gcca

agac

gctg

atttt

ctgc

tcct

atag

cctg

gcaa

ccttg

tggt

acat

ggga

ctac

gtcc

ttta

1569

2735839

MGC48

NO

tata

cata

tgtc

tgcc

tcta

ataa

a628

1570

3660480

___

NNOO

tgag

accg

caat

tcca

gcac

gcat

tggc

agga

cct

1571

2655657

___

NNOO

tggg

agga

ggac

gtct

ttggg

attc

cttc

tcttc

atga

gctg

c1572

2848543

NNOO

agca

taaa

gaaa

gttg

gcct

gggt

tttcg

tgac

tcgg

cagg

gtcc

actc

agttt

aaaa

tgc

1573

3397172

—NO

ctgc

cgtg

ggcc

cattg

acca

gagc

gacc

tgct

gtct

gatg

cc1574

3790842

___

NO

atgt

ggcg

aatg

ggta

gaag

aatg

t1575

2824108

___

NO

ttttc

tgat

tcac

tacc

actg

ctgg

tgtta

cagc

gtga

acgt

gacc

tgaa

gaca

a1576

3361136

___

NO

agaa

gcag

gtat

aagc

caaa

tgttg

agag

ttaga

gaat

gcca

gcct

gcag

ttgtc

atca

ccca

ggct

tagt

acc

1577

3971846

___

NO

atgt

tcac

tcag

gctc

cttg

gtgt

g1578

3294447

ANXA7

YES

gtga

gtttt

ccgg

atat

gtag

aaag

tgg

1579

3850170

S1PR2

NO

gttg

cact

atttg

gggc

acag

aata

atca

ccaa

aagt

gaga

aaaa

cgag

tttgg

gtgg

ctgg

ggag

gact

ttggg

actc

ttgat

gcaa

ggcg

caac

ttgag

aaaa

ttctg

ggtg

tgat

atttg

caca

gaca

ccct

ccttt

caaa

aaca

gcca

cccc

ccaa

gcta

ttctc

agct

ccac

acct

gcag

cccc

agct

aagg

tacc

aggt

ctcc

tgag

caag

gcag

agag

aagc

cttg

agcc

ttctc

tgtg

tcttc

tttca

agaa

cccc

gctg

tgtc

ttcttt

caag

atttt

tttttt

gaga

cagt

ttcaa

gattt

ttgt

tttgt

ttttg

agat

ggag

tctc

actg

tgtc

accc

aggc

tgag

gtgg

cagt

ggttc

aatc

tccg

ttcac

tgcc

acct

ccac

ctcc

cggg

ttcaa

gcga

ttctc

ctgc

ttcag

cctc

tcga

gtag

ctgg

gact

acag

gcac

ctgc

cacc

atgt

ctgg

ctaa

tttttg

tattt

ttagt

agag

acag

ggttt

cact

acgt

tggc

cagg

ctgg

tct

caaa

ctcc

tgac

ctca

agtg

atcc

gccc

gcct

cggc

ctcc

ccaa

ttgct

ggga

ttaca

ggcg

tgag

ccac

tgtg

cccg

gcct

tcttc

tttca

agtta

tata

gaa

tgga

gcat

gggg

gtgg

cagt

ggct

aggg

acat

ttcct

gggg

acac

tctc

ccct

aacc

cccc

agaa

ggac

ttcac

aaaa

acct

gtgg

ataa

tgga

aggg

atgt

tacg

gtac

aaac

gtat

attta

tgtg

tgtg

tgtg

tgta

tgtg

tgtg

cgcg

cgcg

cgtg

tgca

cata

ggcg

tgat

gtct

gtga

ccct

c

1580

3918219

NO

tgcg

gattc

gtct

gctc

cacg

cagg

gtgc

tctg

acgt

actc

tgtg

tggc

ctgg

agct

caga

aacc

tgtg

ctgg

actc

agtg

1581

2370552

NO

gttg

gggt

gaac

tgaa

cctg

tcca

ttt1582

3476124

NO

gagc

ggga

tcga

ggcg

ttttta

ataa

ttcga

gttg

ggaa

gacc

cgga

tggt

tcat

caaa

atga

tggt

gttg

agca

cccg

ggag

gcag

acat

tggg

tattt

gtt

caca

atttt

gcac

ctgt

aaga

aaat

gttc

cttta

taac

tttca

agga

ttgcc

gtga

gcgt

ctttg

gggc

ctttt

cattc

atgt

acaa

gtttc

attc

atta

ctat

tcaa

ctt

ggta

gact

tggt

gaaa

aatg

taaa

agca

ttctg

tattt

ggat

cagt

cttg

ggaa

ctaa

atttg

tcgt

gaat

tggg

gcct

gtca

caga

ttgcc

tcca

gtgt

gcat

cctc

cacg

caga

ccct

ccttg

ctca

gtct

ccct

ctgg

cgcc

catg

ggga

agcc

gtgc

tgtg

gttg

gcag

tgcg

gcca

tctg

ggct

gccg

caac

gtgg

cagg

gca

ccgt

ccag

caag

actg

cccc

ttagt

gcag

ggct

aagc

aagg

aaaa

gaag

aagc

ccaa

aaag

gcgg

gttc

tttttg

atac

ttgta

attc

aggc

gtcc

tcc

agag

tg

1583

3929

424

C21

orf6

NO

ctgt

tgct

gattt

tggt

gaca

catc

tctg

ttgat

atca

gtaa

atat

caat

tgat

aagt

aaaa

aaat

atgc

aagt

ctta

acttg

gatg

tcttt

catc

ttgca

tgtg

ctca

c6

ctcc

ctcc

cctc

tcac

ccag

tcgt

ttggg

ttgttt

gcct

cccc

ttact

gtca

tatc

ttcat

agtg

tgga

acta

aaac

gtag

aaat

gagg

gaag

tata

gtgg

acag

atgt

ttccc

ccac

ccct

tcttt

tacc

tagg

caag

agat

tagg

ggag

tcttt

tttga

ttaaa

gaga

gtag

gtcc

aaaa

taaa

gacc

ctga

aaca

ctaa

aatc

tggg

gatc

ccca

acaa

aaga

actg

gctc

agta

ccta

gtga

tccg

acgg

agac

acct

ctgt

taga

cagc

tcct

gccc

acac

acac

agct

tcca

gtct

tgct

cttc

tat

atga

acag

gcag

ttaac

gatg

atca

taag

gacc

aacc

tgag

cagc

agaa

ccaa

aggg

actg

agga

aaca

gaca

gtgc

tggt

acaa

gtat

gcaa

gtttt

ctgt

aaac

agat

tact

ttcaa

acag

ttggg

agcc

ccag

ggag

ataa

taga

aggt

atcc

tact

caac

agga

gtat

atag

aatg

ctgt

agaa

gagg

aata

ttgta

aga

acaa

gaac

tatc

tcttg

aaaa

ctaa

aaat

atga

taac

tgaa

atat

aaat

ttaaa

tagg

attg

gaag

ctaa

agct

agga

aatta

ccct

agaa

tgttt

tttga

gaa

atgg

aaaa

tacg

aaga

ccaa

aaaa

ataa

aata

aaac

tatg

ctgt

gaaa

gaga

aaga

ttagc

atttg

agaa

ggcg

gaag

ttggt

cctg

ctca

gatg

cggt

tttca

gatg

cc

1584

2418445

—N

Oag

gtttc

aacc

caac

tgga

cctg

cttg

1585

2977983

EPM2A

YE

Saa

ttcta

ccaa

atat

ctgg

ctgg

gtag

1586

3074397

CNOT4

YE

Sttc

atcc

aatc

acag

tgca

cggt

cccc

ttttg

aagg

ggca

gtaa

caga

gtca

cagt

cgtta

ttctc

agac

aattt

tcgc

catc

ccaa

ccct

atcc

caag

tggg

cttc

ctcc

tttcc

ccag

ctcc

ccac

agac

atcc

agtg

actg

gcct

acag

cacc

agaa

1587

3320669

USP47

NO

cggt

ggag

cctc

atga

tctc

ttatc

ttttg

aggc

tgag

gcag

gtca

catg

caac

aaat

tgtg

accc

tgct

cccc

acaa

gtca

tgca

aagg

ttttg

aaga

gcttt

tac

cgtg

gggc

agat

gaac

ttgtg

tcaa

ccat

gcac

accc

tgtg

agaa

ccaa

gtac

ctgt

gtttc

taag

gcgg

gcac

tcaa

ggtg

aggg

gtgc

attc

tggc

cOC

Oaa

agaa

acaa

aagc

tgtg

gtttc

agga

ccat

gccg

tgtg

tagc

tgat

ctgt

acgg

gacg

tgta

tgta

agga

agag

caat

catg

atag

ataa

gaac

agtg

tgt

gaag

cagc

cttc

acac

taga

gtgt

ttggt

catc

tctta

taat

gtaa

ggga

aggt

acttt

aaaa

ttctg

ggaa

gatg

cgat

gaac

tcat

gtcc

cagt

caga

aaat

aat

ccaa

tgaa

ataa

gcat

tggt

tgcc

aggc

caca

gtta

ggaa

ttgta

1588

3562057

NO

gagc

aaaa

atat

tgtc

aggt

ttcttg

ctgt

ggttc

tgga

tgttc

agta

gcag

gctc

atttg

1589

3924690

DIP2A

YES

gggc

ctcg

tgga

gcat

tcgt

acttt

gagc

gtcc

acag

gtgg

cttc

tgtg

aga

1590

3029146

—NO

agtc

aact

cggg

gagt

caaa

ttagg

aaag

gcttc

gaag

gatg

ggca

ggac

gtaa

gaat

ccag

agag

gaga

ggga

tgttt

ggag

aaca

gaaa

gtgg

aag

gttc

ctgt

agga

aaat

gata

gagc

tata

cttg

gaga

ggca

agcg

gggc

1591

2480430

—NO

tcttc

actg

aagg

tgcc

agcc

tatg

ggtg

gact

cgtg

atct

agac

ctaa

aggg

ttagt

gtga

gttc

ctag

agga

aaag

aaag

ccat

gagg

caga

ttgtg

gaa

ggct

ttgaa

ggcc

aggt

ggag

ggcc

ttgaa

cttta

ttcca

taga

caat

gggg

agct

attg

a

1592

2923442

NO

ctgg

gaag

aact

tcag

gctg

ttgttc

aggg

catg

gata

tcac

cact

gtcc

a1593

3393487

FXYD6

YES

cctc

tgga

acct

gagg

cggc

tgct

tgaa

ccttt

ggat

gcaa

atgt

cgat

gctta

a1594

3879288

...

NO

gcttt

caag

aata

cggc

catg

tctg

cattg

ttggc

ttaca

cgca

gaca

cacg

ctcg

ggttt

ttcat

ttggc

aggg

tg1595

2889490

AGXT2

NO

catc

tcat

ccaa

atac

acgc

tattg

agaa

ggcg

agcc

tgac

ctcc

ctct

taca

gata

aagt

cagc

tttca

gagg

ctca

gggt

gggg

gggc

ctgc

ccga

ggc

L2

cata

atgc

tacc

cacc

ccct

cctc

ctaa

ccac

tggt

ctgt

tgga

ataa

ccca

1596

2915

334

DO

PEY

YE

Sag

attg

gttg

agag

tctc

cgttt

gcca

cagg

tgcc

aact

ctcc

attc

tcaa

gtgt

tcct

gtttt

tcag

agtg

ttact

tttaa

gaat

gtct

cccc

aaca

tctta

cctc

ac1

tctg

gcct

acca

tgat

taca

gaac

tt

1597

3186

622

—N

Oct

cata

ttagg

atgt

ggac

ctgt

ccaa

atct

tcag

ggag

tcct

ccct

cccc

aggc

cagg

caat

ttctc

cagc

acca

aggt

aacc

actg

ttttg

ttctc

tattg

cta

tgga

ttggt

tttgc

ttattt

gtaa

attta

tttgt

agac

ttggt

ccct

atca

ctac

gaat

tggt

tttgc

ttattt

gtaa

acttc

atat

aatta

gaaa

tcat

gagg

cattt

tcat

aagt

gtgt

tttca

acttc

tata

aaga

gaaa

caca

atgt

acct

tcttt

tttgt

gtcc

taaa

ccttc

tttttc

tcag

tccc

cttc

cctg

taca

tgca

ctttt

caaa

gtga

ttaga

ggta

caga

gaac

tcttc

ctct

aatc

taat

aaac

aaaa

tgat

acaa

actc

aata

atag

gtgg

aaat

gccc

ctca

ggttc

aatg

ctag

agag

aaac

tgca

ggga

atgg

tggg

gact

atgg

caaa

ctat

ggaa

a

1598

3720992

—NO

cattt

ctat

ggtta

ttcgt

ggaa

tgac

tcttt

gacc

acgc

ggag

aagg

caaa

acttc

agcc

atttg

tgttt

ttttc

ccct

tggc

cttc

cccc

ctttc

ccag

gaag

tcc

gact

tgttc

a

1599

3916840

NO

tggc

aattt

caac

agttc

gtca

ctgc

acgc

tgcc

tctta

aagg

1600

3959370

___

NO

catg

ggct

tctc

agat

ccag

gtga

tgcc

ca1601

2571999

SLC35F

YE

tggt

ttcac

tcag

cgca

ggcg

aatg

gctc

ttggg

attg

ttattc

ttctg

cttg

ttgat

gtga

tatg

ggttg

cttc

ctct

gaac

ttact

tcg

5

1602

3757901

—NO

tattt

cctta

ttaca

tgttc

caga

cagg

agtg

ctag

ccca

1603

4002896

___

NO

ctttc

atgg

agca

ccgc

tgct

cacg

acct

gtta

cagt

ctag

aaaa

atgg

aaaa

actg

aaaa

tggg

tatc

tatg

ccac

ctaa

1604

4013965

—NO

aaaa

tcta

ctgt

ggag

ggag

tgca

aa1605

2327098

—NO

atac

ttgag

agta

aatg

aact

gctc

ttgtta

cttta

ctat

gtca

atta

caaa

gctta

aaat

tcac

acaa

gcca

cacg

acat

attta

agaa

tgca

tgtg

ttggg

cca

ggtg

c1606

2381607

NO

gaca

tcag

agtg

gaac

ttggg

cgat

gctg

ccaa

catg

a1607

2995272

C7orf41

NO

cact

cccg

cttc

agtg

gggt

ttcta

tgga

gttg

tcttg

gtag

ccttt

gcca

ttttg

aattt

agag

tcca

ttttg

tggc

tgac

tattc

tctta

agttt

atgt

tgga

gaat

taac

attc

gctg

actc

gaat

gtag

agaa

ctct

gaat

gtat

taag

gata

ggttt

tgag

tcct

caca

ggtg

acct

tact

gagg

gaaa

gcat

ggca

gaga

agaa

atgc

agtc

tgca

ctttt

tatg

tact

tttta

agtg

tccg

taag

tgaa

aggt

tttgc

ttata

aagc

atga

atttt

aata

tcta

gtca

ttaaa

ctgc

acaa

gtgc

aaat

acaa

ggg

cagg

aaag

gata

atca

ctta

gcttt

ggac

taag

aggg

taag

agag

gccc

agaa

gcct

ttaag

tgttt

tgcc

atta

ctga

gtta

cctg

ggta

tgta

gcga

ctgg

ttc16

0832

6178

9SU

FUY

ES

gctc

caac

ctga

gtgg

tgtc

agtg

ccaa

gtgt

gcct

ggga

tgac

ctga

gccg

gccc

cccg

agga

tgac

gagg

acag

ccgg

agca

tctg

catc

ggca

caca

gcc

1609

3934

119

SIK

lN

Otg

tgcg

cgtg

cattg

atta

ctat

ccat

ttcttt

agtc

aacg

ctct

ccac

ttcct

gattt

ctgc

tttaa

ggaa

aact

gtga

acttt

ctgc

ttcat

gtat

cagt

tttaa

agca

gccc

aggc

aaag

atca

tcta

caga

ttcta

ggaa

ttctc

tccc

ctga

aatc

aaaa

cctg

gaag

acttt

tttttc

ttattt

tagt

tgag

aagt

ttcat

aaac

tgct

caag

gatta

gtttt

ccag

gact

ctgc

ggag

gaac

ggca

ggaa

gaac

ctca

gaga

gggc

agag

gtga

cttc

aaag

tgct

gggg

actc

cgtc

ctga

gggt

cact

tggc

cctg

agcc

cctg

cgtg

ccct

tgcg

gaag

ccca

gaag

cttc

ttcct

gctg

cacc

tccc

gtttc

cgct

gctg

ctga

cgttt

atgc

atttc

atga

tggg

gtcc

aaca

agaa

cacc

tgac

ttggg

tgaa

gttg

tgca

atat

tgga

ggct

gact

gtag

ggct

gggc

agct

ggga

gaca

ggct

catg

gctc

atgg

ctca

tggc

tcag

ggc

ggtg

cctg

ccct

gggc

cggg

accc

ccct

cccc

accc

ccca

ccta

ggct

ttttg

ggttt

tgttc

aagg

aagg

taaa

gtga

gagg

tttag

gtca

gtgt

tttta

agttt

ttgttt

tttttt

taaa

gcaa

atcc

tgta

tatg

tatc

taca

tggg

agac

aggt

agac

acta

ctta

tttgt

taca

ttttg

tact

atac

gtttg

tgttc

cagg

tttca

gct

tccc

tcgc

tcct

gttg

ttaag

aagc

gtcc

ctgt

cagc

acag

gtgt

gcat

tgag

gaag

gggc

ccca

gggc

cttc

gctc

cctc

agca

ctgg

ggtg

gagg

cgg

cagg

aagg

ggcg

gccc

ttacc

tggc

aggt

ctgg

gcgc

acct

ttagc

aggt

ggac

tccg

tggg

gctc

cacc

agcc

agaa

gcct

ctgg

aagg

caac

gaag

gcaa

tgct

gctc

cctg

agtc

cagt

cccc

gccc

ccaa

accc

agcc

cagg

tgcc

ttcag

ctac

ttcgg

cttc

ttaaa

ccct

gcag

tgtt

1610

2748

304

NO

actc

aagg

tctg

tcca

tgct

ggtg

actta

gagt

agtg

ggat

ttaaa

ccag

agga

tgca

cact

tgga

ggca

cttg

aaga

tgttt

caag

ggac

atgc

aggc

attg

aata

tttaa

agga

aatta

attg

ccga

ttctta

gatc

ttgag

tgtta

atca

gttc

taac

actg

accg

tcct

gaga

aaat

gcct

atgg

ccca

ggtg

acct

gctg

gtttt

ccttt

caca

ccttc

tcttt

catg

atta

ccat

tcttt

aaag

ggaa

gaca

tacc

tttca

ccta

cccc

ttatc

agag

tgcc

aagt

aggg

ggat

aatta

aaat

actg

ctgg

ggct

gctg

ggaa

agtg

agtg

actc

ta

1611

2358329

TARS2

YES

ctcc

agca

ccca

tgtc

ctgg

gggc

agca

gctg

aaca

attc

ctag

gtgc

tgttc

tctg

ca1612

2636804

NO

tctta

tcac

aaca

ctgc

ggcg

ggaa

aatc

agga

aatg

ggttc

acct

ttcag

cagt

cacc

acag

taaa

cttc

attg

agaa

cata

catg

ccca

gata

tctc

ttctg

tgca

catg

tata

tgtta

acag

ctag

ccat

tcag

ccaa

cagg

ta

1613

2907584

KLHDC

NO

cagg

gaag

tcac

taat

ggga

gagt

ggga

ggta

tttga

aaag

gggg

tttcg

tggg

tagt

ttttg

tcct

acttt

catc

tctc

ttttg

atcc

cgac

ag3

1614

3185561

NO

gcga

gtcg

actc

acct

acct

ctttt

caag

ccgg

ccta

gccc

cttc

ccgg

aacc

tcgg

ctcc

cccc

caac

gaaa

ctac

tgct

aagc

caac

tgga

ctac

acttc

c

1615

3752751

—NO

atgg

gttc

aaga

cctg

tttat

gtgc

gaga

acaa

cagg

ctttg

gtgc

tggt

gact

cacc

aaga

tggg

aaat

acag

gaaa

agaa

gcag

ggat

gtgg

tagc

agag

tgt

1616

2366872

—NO

ttccc

atcc

ctgc

tcta

gcag

cctg

1617

2389086

NO

tgag

agag

gtttc

tattg

ttcac

tttag

aaaa

atgt

aggt

caat

gtaa

tggg

tgat

atct

gttc

ttaat

tattc

taag

aatta

aatc

ctgt

atgt

tatc

agtc

acct

atta

tatg

gcac

accc

tcag

ggg

1618

2523976

NO

aggc

aagg

ggta

aagt

ccag

gatg

aggc

1619

3394423

THYl

YES

gcag

ttcac

ccat

ccag

tacg

agttc

agcc

tgac

ccgt

gaga

caaa

gaag

cacg

tgct

ctttg

gcac

tgtg

gggg

tgcc

tgag

caca

cata

ccgc

tccc

gaa

ccaa

cttc

acca

gcaa

atac

a

1620

3510

096

POST

NY

ES

aggg

agaa

acgg

tgcg

attc

acat

attc

cgcg

agat

catc

aagc

cagc

agag

aaat

ccct

ccat

gaaa

agtt

1621

2974447

—NO

atgg

atta

cggg

ctttt

atgt

gggc

agca

acttg

tgcc

tcag

1622

3000375

—NO

gtca

ctttt

gtgg

cctc

ttggc

tgta

ccttc

cctg

ggac

agga

cacg

gtcc

tttct

1623

3498077

—NO

gcag

ttatg

tata

caca

gggc

aatc

atca

gacc

ataa

tcat

tact

gttc

gagg

ccag

aaca

gaga

cgac

tagc

tctc

tgtg

tgcc

tttcc

caag

tctc

accg

tgat

ggac

tgtc

ctct

c

1624

3670758

—NO

gtct

tcag

agct

agcc

ggct

gtgt

cttc

tccc

cgttt

ctttc

actg

gtga

ataa

ccttt

cgttt

gaac

cagc

cttg

attg

ttctc

tcca

tgttc

cact

gtgg

ctcc

cca

tgga

cact

gcta

ggtg

gaat

ctct

gaga

aaac

aggc

acttc

gcag

tcgg

cgca

tcttt

ctct

gcca

gctta

ggga

ttgcc

gtca

aggt

ggag

gaag

ggta

ttttg

gcca

tgttc

ggag

tcgt

tgttt

tta

1625

3418194

—NO

cagt

tagc

tgta

gaga

tgtg

attta

gcaa

agttg

gtta

taaa

gtgg

gtttt

tgta

aattg

tttcc

ttatta

ctgt

tcttt

gtag

aattg

aaga

tgta

ttctc

tccc

agca

aaa

tagt

tcac

ctgc

agat

cattg

aaaa

gtttg

gctg

aaga

aagg

ggtta

ttttg

gtgt

gggg

gtag

gagg

cttc

tgtg

ggct

gggc

atgg

tggc

ttaca

tttgt

aatc

ccag

cact

ttggg

aggc

tgag

gcag

gagg

atca

cttg

aggc

cggg

agttc

aaga

cttg

cctg

acca

acat

aatg

aatc

tccc

atct

ctac

aaaa

aga

atca

gcca

ggcg

tggt

ggcg

caca

cctg

tagt

ccca

gcca

ctca

ggat

gctg

aggc

ggga

tggt

ctct

tgaa

cttg

ggag

attg

aggc

tgca

gtgg

agca

gtac

tcgt

accc

1626

3687863

ZNF764

YES

gagg

tggc

gaaa

tgtc

agac

acaa

acgg

ac1627

2438168

___

NO

ggga

atat

agag

aggc

tgct

gaga

g

OC

ggct

ctct

gtac

caac

aata

taac

agac

tttac

agta

aaag

aaat

agtg

gcag

ggtc

agat

gatta

caca

aattt

ggta

gggg

cattt

gtat

gcca

gtca

acaa

1628

3059966

KIAA

13

YES

24L

ttattc

cttc

tgaa

agta

aggg

tttcc

gagc

agcc

ttatc

atca

caat

c

1629

3281916

___

NO

aaaa

agta

aggt

ggat

atgt

gcag

tggc

t1630

2838994

___

NO

gtag

aaag

ggga

atgt

gtac

tgct

agag

gtta

cggg

ctttg

a1631

2724513

UBE2K

NO

gtgt

acca

agac

tagc

aaga

gtttg

cttc

agga

ttttg

ttgaa

taat

taag

ataa

tattt

tgag

tgtg

tcag

ggcc

attc

aaat

tgttg

gtgt

tgca

tcac

agct

acct

taac

tgttt

ttaac

atgg

atcc

tctg

tgcc

tgtg

aattt

acttg

catg

cttg

tact

tgac

ttctta

ggat

gggt

agct

gaaa

agac

cacc

atttt

aagc

atttg

aga

attc

ttaaa

tatg

aaat

ttattc

agaa

ttgaa

gatg

gtga

ccta

ttcag

agcc

tttttg

tcct

tgtc

aaca

gact

ggga

cagt

gtct

gattc

cccc

ttcac

cccc

ccc

accc

ccgc

cttg

ccac

acac

agct

aata

ttcta

atgg

taaa

tttct

ctgt

atca

ggtg

ggga

aatg

tgct

gaag

gaca

gtat

gtat

ccct

tgct

tcat

tttta

ggtc

gtag

gtttg

gaat

gtct

tgtc

ccag

ttcttc

aaac

actc

ttaaa

tttttc

ttaag

taat

gtaa

aaat

ggaa

ctgc

caat

tttat

ttctc

ttgca

aaaa

tagt

aaat

acttg

atgt

taca

ttattc

ccag

gttta

atga

aaga

accc

aact

tagt

ttttc

agtg

aattt

gaca

ccta

tttttt

agtg

atga

aattt

ttcttt

gaga

actg

gcaa

ggat

gcag

tcag

ctgt

ttgc

agttt

ttagc

ctga

1632

2415

597

NO

ccct

gtta

atct

tgtg

gtca

ccat

acac

tcttg

ggtta

gctg

tcaa

atta

gggt

ttctc

cacc

ctgc

ttttg

tata

atga

agttt

ctaa

tcct

aaat

gcag

gatg

ccc

cattc

tgag

cctg

tttgt

attta

acag

aaaa

tagg

gattt

tcgt

ccca

ttttta

tctta

ccaa

ttcac

tccc

caac

tgtg

ccag

aatg

ccca

gagg

taat

agcc

tttt

ggaa

ggag

ctttc

ccat

gcta

cattc

cagc

aggg

taaa

acaa

tctg

aaaa

tgttc

ttgcc

ccttt

tatc

actg

agttc

tcca

tatc

ccag

gcta

tttta

taaa

taga

atttt

tccc

taca

gaaa

atat

gtaa

agcc

attg

cgaa

gaga

aaac

ttttc

taca

cata

gaaa

acat

gata

atttc

tcat

tagt

tttgg

aaca

atac

aggt

ctac

tcta

agttg

tttct

tattc

tgga

gtac

aaaa

tttgc

atttt

ataa

tgta

aattg

ggac

actg

tata

ctag

ctttc

tc

1633

2818227

—N

Oca

ctat

gtca

actg

ggtg

tcttt

gcta

agttt

ggca

tcaa

tatg

gtga

cctc

tcgg

gagc

aggg

gacc

acta

ggtta

cata

agga

gggg

tgaa

ctgg

ccca

gat

tgga

aatg

gagc

aggt

caaa

actc

ccat

gcta

acca

gtag

tgag

atgg

agcc

t

1634

3412324

IRAK4

NO

atat

acac

ctat

ctca

acca

tttttt

taac

tgat

tttttt

ccta

aata

ttcttc

tttac

cttta

acaa

ggca

tagg

ctgt

tgca

ggac

agtg

gtta

ttaaa

gcat

gggt

tgaa

cttc

caaa

atat

a

1635

3598210

ANKD

YE

Sgt

cggg

gcca

tatg

gctg

tgct

gcag

cgac

ttgtg

gaca

tcgg

gctg

gacc

tD

lA

1636

3728

164

—N

Oct

tgct

aacg

ctcg

ccag

agaa

atat

tccg

tgga

ggtg

ttaaa

acaa

gact

agtg

gaaa

gaaa

tggt

aact

taaa

aaga

aaga

aaat

ccat

ggca

gtga

agaa

caga

tttca

tatta

gtac

tgtc

ataa

tattc

tcta

atgt

atca

tata

aata

aaaa

tctg

tttag

acca

gaat

tttaa

taag

tcac

caaa

ggaa

ggttt

tgaa

tcct

aca

gttta

tgta

tccc

ccttt

gcga

tgta

aatg

ttcac

atct

caag

tgaa

gtag

agtg

ggga

gacg

cttc

ggag

acta

gagg

ctgt

taat

tagt

gagg

tata

ttttg

atca

gggc

aaga

agac

tggt

tcat

tcta

tatc

ttcgt

atttc

tctg

gatg

atta

tttca

ttttg

taaa

atat

gtaa

gagt

tccc

cccc

agcc

cctta

tcttt

ttaaa

aatt

aaaa

tggt

catg

ctct

tcta

aaaa

gatg

actta

atttg

aagg

ctttg

gaga

catg

agga

tgat

gggg

atcc

atca

ctcc

ctgt

tcttt

gctc

ccttt

ggac

tgga

gtg

ttggc

tgtc

tgga

agag

ttttg

cttg

agct

cgtg

ggtta

ttttc

ttcta

tgtg

gagg

aacc

aaga

gact

cttta

gcat

ctttc

agca

agag

cgag

gtct

gggt

gta

ctca

ccat

ctgt

ctta

atta

tcct

tgtg

tata

agaa

aaca

ttccc

atct

tttcc

caat

tgcc

atttc

cttc

ctta

acttt

taga

ggcc

agaa

cctc

atct

gttg

atgc

agg

gaga

tctc

acttc

tttaa

ccta

tttct

agttg

ccttc

agtc

acag

cggg

gtgg

ccag

gggc

gagt

cact

taag

cctc

ccca

aggc

tcag

tttcc

tcct

ttgta

aaag

aggg

agaa

ttata

gtac

tcac

tgcc

tgca

gtta

gttg

tttgg

agga

taaa

tgca

aaat

tcttc

actg

ggag

tctg

gcat

aaaa

cagc

actc

cgca

aatg

tct

gttg

atct

tatta

ttata

gaat

tatta

ttttta

ttatta

ttattt

ttaag

acgg

agcc

tcac

t

1637

2779

706

NO

acct

ggta

aagt

gaga

agag

tgat

cagg

agaa

gata

atttg

cata

gtat

atat

agat

ttcta

ttcca

tttat

ataa

aacc

cttg

aatg

gtac

ctta

gtag

aaac

aat

ataa

aata

aagc

taat

atgg

gtta

gatg

ataa

tgtg

gtta

agtg

gattt

tttttt

cctg

tctg

aaca

aaag

aact

gaca

attta

atca

atag

accc

ctgt

cagt

ctgg

agag

atgc

ttcta

gtgg

tcag

cacg

gcac

tctg

gtct

ttgtg

1638

3394

582

—N

Oaa

cagc

tcaa

catg

tgtc

ggga

tgtc

cagg

gaa

1639

2429

120

TR

IM33

YE

Sca

tattt

tgaa

agca

cggt

gtga

tcct

gtcc

ctgc

tgct

aatg

gagc

aata

cgttt

ccat

tgtg

atcc

cacc

tt16

4034

2875

6N

Oca

gcta

aggt

aaat

ctgc

ttggt

ccaa

acaa

aaca

aaac

aaaa

caaa

acac

caga

ctgc

aaca

ataa

cagg

aaaa

gatc

ctct

tcag

tgat

ttatg

ttgttc

tct

tact

ttcat

aact

agttt

gaat

gcaa

ggct

ggta

aagg

gata

caca

gaga

atca

ttattt

taaa

taac

aaaa

gcca

ttcaa

aact

ctct

ctac

ctgt

caag

gat

gtttt

atgc

tccc

attc

ttattt

gtttg

gcag

taaa

cata

ccttg

ccca

cagt

cgcc

agca

tcaa

accc

acag

gaca

agac

attg

catg

cttg

gtca

caga

actta

tcag

cgag

ccag

gaat

tcgc

acat

c

1641

3595

186

NO

ttgttt

aggc

aaag

cacg

ttatg

gcttt

ttcttg

ccta

gttta

ggtc

tgtg

ctta

atga

ctac

tgga

atag

cagc

aaac

ataa

catc

ctga

taac

atttg

ggag

gaa

aagc

cata

tttga

aaat

tggt

gaaa

tgca

ataa

tcttt

aaac

cagg

aatc

atca

gtttg

ctaa

taaa

aggt

atat

ggct

ccaa

gtta

cgta

ttttg

tcag

ggtc

ctc

tggc

atttt

cact

agtc

atttt

gcta

gtgt

gtac

aatg

attc

ctat

cttg

ctgt

aaaa

cttg

gtga

tttttt

tata

ttgttg

aact

aggt

gaca

tgaa

tattg

agtc

agat

cac

ataa

tctta

gagt

aaca

cata

agtg

atta

tgta

gcgt

tgtg

ggtg

gaaa

caat

tctg

gata

aaaa

gtgc

atga

cagt

tcag

aact

actg

tgca

ggca

gcct

gtc

tgaa

atca

ggttt

aaaa

attg

gccc

tgtc

tcca

gctg

actc

gtttt

gtc

1642

3959

259

NO

ctca

agca

cagt

catg

attg

gtttt

gtat

tttct

tctc

cagg

ctac

ataa

taat

tttttg

acct

ggttt

tcttg

atgc

ctta

taat

tctg

aatg

ctgg

acttg

tctc

tttat

tacc

tgcc

agtta

gc

1643

2604457

—NO

acag

cagg

aatc

tgtc

agtg

tccc

tga

1644

2843218

PRR7

NO

ggcg

cgcg

cacg

acttg

agac

ctgc

cacg

ggca

gccc

ccgg

ccgc

gggt

cccc

gagt

gacg

ctgg

cggc

acct

gaga

gtgt

ggcg

cggg

cccg

gggc

cacg

cagc

ggag

ccca

gtgt

ccag

tgaa

gcgt

ctga

ggac

ccgc

cgcc

1645

3039818

NO

gctg

acct

attg

ctga

ggac

tatg

agaa

aaaa

gtta

ttaca

gaat

gagt

cata

tgga

aaac

acttg

caaa

c1646

3483658

___

NO

gcag

acaa

tccc

catc

agct

taag

gttc

ccgt

cacc

aggg

tttcc

cttc

atcg

aaac

tttgc

caca

gtca

1647

3605805

SCAND

NO

tgta

gtat

tcac

tact

ccag

acct

ttttc

aagt

tgaa

tttttt

ttcttt

ttccc

tatg

tctg

ttctta

cgta

tttttt

ttaaa

ctttt

atttc

agta

gtgt

ttggg

gaac

aagt

ag2

tgttt

ggttg

catg

gaaa

agttc

ttcag

tggt

gattt

ctga

gattt

tggt

gcac

ccat

cacc

caag

ggta

gtct

ttttta

tcca

tcaa

gtct

gtac

ccaa

tgtg

t

1648

3659197

—NO

agag

agcc

tagc

ctga

atat

gcca

cagc

cgca

caga

gtttc

tcct

1649

3775146

—NO

cagt

taag

tgca

gctc

ggtg

agtc

ccgg

cagt

tcct

tccc

ggca

ctgg

ctcg

tccc

tggg

ttctc

aagg

ttcca

tgcg

gcca

cagc

gtcc

gtcc

acct

gtcc

acgc

gagc

caca

tgct

gaaa

tgga

ggtg

gata

aaat

tcat

cagg

cagc

tgct

gtaa

cacg

gaaa

tgtg

caga

tgcc

agag

tagc

ttcgt

c

1650

2534837

—NO

tgtg

cacg

catg

cagc

actg

cgat

aacg

gggc

aggg

ggag

ttagg

tgat

tgct

taaa

gcac

aagt

gtgt

aggg

aaga

aaca

aagg

cagg

aggg

gcca

tta

agga

gcct

gtag

agtg

tttgg

gtcg

gggg

ctca

cattt

gtac

agag

tgag

ctga

1651

aaag

ctac

aagc

atgg

ccgc

ctgt

ggta

tcga

ggtg

ttgca

aaca

atat

ctgt

gttg

cgct

tcct

gtttt

aacc

tacc

tcgt

tttgt

ttgttt

ttgttt

cact

gttc

atc

00

2705269

NO

Ul

acag

cagt

gtta

tctc

cagg

agac

atat

agag

agct

caac

cggc

aatc

tcag

gtgc

attta

acat

tttta

aaac

gaaa

cagt

agttg

acca

aattt

ttcttc

ttaa

aaaa

ttgga

agtg

gggg

gaat

ccaa

tgac

aaaa

acta

atgt

ggct

tgttt

ctgg

agaa

aata

atta

ctgt

aaat

ggaa

caac

aaca

acaa

aaaa

aact

acga

tctta

ctga

ctttg

ccta

aata

caca

agca

gctg

atgt

acta

ttaat

gaga

acga

aata

caca

ttagg

aaaa

tgga

gcca

tttca

atct

agtg

gtttg

ggca

aga

tggg

gaag

agaa

gggg

aaac

attc

tagt

ttctg

gatta

catta

ttatg

cccc

tcct

gaaa

aggt

ggttg

tcat

ttgca

tttat

ttaaa

gcag

gtaa

tatg

cagg

aatg

taac

tgag

gatta

tcttc

aggc

aatc

agca

agat

atcc

tcct

catg

gtcc

cttta

gctc

tcaa

aagc

aatg

aaat

cctc

ctgt

tctc

atttt

tact

gctg

tggt

tgt

gctg

ctga

acaa

tact

atct

tctc

aaat

tcca

tgcc

acaa

attc

agca

ataa

ctttt

tgga

ttgaa

tttaa

caac

tact

gtaa

ttgga

tgct

gatg

tgga

caaa

atat

attg

atttc

gattt

cact

cccg

aatg

tgat

tgcc

acca

gctc

1652

3479

382

GO

LG

AY

ES

tcag

caaa

cagc

ccgt

ggga

aacc

aag

1653

2320

890

NO

gtttc

atga

gaca

gcga

tctg

ccta

acca

ttcac

tcct

ccta

gaag

caaa

agct

accg

tgat

cattg

aggc

acag

ccgg

tcttc

atat

atcc

tcaa

agga

ggg

ggat

tagc

ttcca

catc

ccttc

tcta

ttcct

ggag

gtgc

cagt

agtg

ggag

agtc

atgg

caga

agtta

ccag

aggc

aagt

gggg

caga

ggca

agta

gggt

ata

tgttt

ggat

cagt

ggat

cagt

gtcc

tttat

tgtg

caga

aaaa

gcta

aaat

taca

gattc

ttctg

aagg

gata

cata

gcag

ccgt

ttcac

caat

gtcc

ctca

gtc

cattt

gtcc

aggt

ccag

a

1654

2824597

NO

tgta

ggtg

ctgc

tttaa

tgct

tgga

ctga

tgtta

ttgttg

tggg

agtg

gatta

gtta

ttgtg

agca

tggg

ttggt

tata

aaag

caag

gtca

aggc

tggg

1655

3916352

NO

taat

gggc

ctga

gtgt

cacc

aaga

g

1656

2900

984

HL

A-F

YE

Sgg

aatg

aatg

gctg

cgac

atgg

ggcc

1657

3003

162

GB

AS

NO

ccct

atgc

cgat

gttg

tcct

ggat

tacc

tttttt

gtcc

tgtc

ttatc

acttc

gtct

cctg

tctc

gggt

ttctg

gctg

tctg

ttcct

atttc

tattt

gatg

ttgtg

ctct

cact

tca

cacc

cagc

atgt

agaa

tcac

cttg

ctct

tcca

acttc

cctg

tctg

tgcc

actc

acct

tgttt

tact

cagc

ccgt

tcct

tagt

tctc

tgtg

gtga

atct

gtca

ccta

agct

gtgc

attc

ttcat

cgga

catg

tattt

tggt

tctc

ttgttt

ccttc

tcca

tctc

tctc

tcca

agcc

tctc

gagc

ccca

ttccc

aagt

agct

tttttt

ctga

ctac

cttt

ctgg

gctc

caag

ctat

acct

gtgt

ctcc

ttcct

gccc

tgca

atac

atta

cccc

aaag

tttgt

caga

ttgat

ctgc

ttgag

ttctg

ttttc

tttttt

catc

acgt

tttttc

ttttc

tctg

aaac

tttca

gcag

ctcc

ctgt

ttgca

gaac

ataa

agac

ttaac

tcct

gcct

ggttt

ttagg

ggtc

ccaa

taat

ggga

ttctg

ccca

accc

atcc

agttc

tgg

gtac

aagt

actg

cctg

cctta

caat

ctcc

attc

aggt

aagg

ccag

ggct

ccta

agag

cagg

tttgg

ggtc

ccca

gcaa

agag

gagt

ggct

acaa

atcc

atg

cgtg

acttt

gtgt

tggt

gaaa

aacc

tggg

cccc

gttg

ccag

gccc

ctttc

tgga

cccc

acct

gaat

catg

tgta

ctgg

gcttc

ctcc

tggg

cact

gcct

cca

atgc

aggg

ttgtc

tattc

ctgc

tcat

gtca

tgcg

acga

aaag

gaaa

tgttg

gaca

taca

tttcc

ctag

caga

atcc

ctct

ttccc

tgtc

ctcg

atttt

cattg

atcc

catg

ttattt

ctga

acat

tcat

gagt

cacg

catc

agat

acat

ttaat

atca

gatc

ctaa

tttaa

aaag

taaa

tgct

actc

ttcca

aaag

taca

catg

atgt

ggtc

act

atac

tggg

tcat

aaag

atgt

atgg

gtttt

cagt

tagt

taga

ctta

gacc

gt

1658

3743421

—NO

ggaa

cagg

agaa

gccc

caat

tttca

gaag

agag

ggga

gttg

attg

agaa

gtgt

aaga

ttgtta

cttg

agaa

taat

cttg

aggg

tatg

aagg

tagg

gtaa

ggga

gaat

ggtg

ataa

actc

1659

2949593

DOM3Z

YES

ctgg

cggc

ccag

tcac

cgtg

tctg

taca

ccaa

gatg

cacc

ttacg

ccttc

ctgc

cc

OO

acgg

caga

agat

ggtc

cctc

gcgt

ctct

ccca

tcttc

cggc

tatg

gaac

caac

acac

1660

3824798

MAST3

YES

1661

3933890

___

NO

tctc

cgta

accc

tata

acag

tccg

ata

1662

3340811

___

NO

cattt

attta

tgat

caac

caga

gaga

ctaa

acag

tgga

ctca

tggg

tttgg

actc

tattg

caat

tcaa

1663

3888249

DDX27

YES

gatg

aaga

actc

acca

acac

aagc

aaga

aggc

cct

1664

3932432

___

NO

atag

ggaa

tgtg

ctttg

agct

gttt

1665

3941419

___

NO

cagg

aaaa

gagt

tggc

ctgg

acct

gca

1666

3976987

CCDCl

NO

gttg

actg

cgtg

tcca

ttgttg

ttata

gttg

gttg

aatc

tgtc

ccat

taat

tctc

cttc

c20

1667

2892314

___

NO

acat

ggcc

agta

ctgt

ttcag

ggga

atat

tggg

tggc

gctg

g1668

3379157

—NO

gggc

caga

gaac

tttac

aatg

atta

tgaa

gatc

aaag

ggca

ttaga

atca

agct

ataa

agag

ccac

tgttt

gatg

ttggg

atgt

gagg

atgc

tgca

ggtg

gat

gtct

gcac

gttg

atgg

tgag

aaca

tggt

cacc

ctgg

ccct

gctg

ggtc

tttgc

taaa

gaga

ctgt

gctc

tgttc

ttggg

gccg

ttttc

atca

cctg

atta

1669

3830022

NO

agga

cggt

cggc

gtgc

agag

ttcct

ggag

tgct

gggg

ggcc

tgag

atgg

ttgta

tgac

gtct

ggag

gattc

agga

gggt

gtat

gggg

tctc

aagg

acac

1670

3904149

CPNEl

YES

ccttg

gttc

agct

gtcc

atttc

ctgt

gacc

atct

cattg

acaa

ggac

atcg

gctc

caag

tctg

accc

actc

tgcg

tcct

tttac

agga

tgtg

gg1671

2408020

NO

tgaa

ccat

ccat

tgcc

taaa

actc

cagc

aacc

ctaa

aagg

accc

aatc

aacc

agaa

gaaa

aaat

acta

atac

ctca

tatc

atac

agca

acct

aaca

tttca

aagt

gcttt

caca

tgtg

ttagt

tcat

gcac

acct

gaca

acag

tttaa

ctga

ggga

gcca

gggc

1672

2437

930

ME

X3A

NO

ccct

gggt

ccag

taga

atgt

ataa

aagt

tgta

agga

aaag

ataa

atag

agga

ggga

agtg

gctg

agtc

cacc

ctga

gttg

ccca

atct

tcag

atac

cagg

gttg

gatc

aggt

tgct

agttt

aaga

ttggg

agct

tcca

gtct

gctg

gggt

tgat

tctg

agaa

tcct

tgga

ttttta

aattg

tagg

acaa

agaa

atga

gggg

ttcat

ttcc

cagg

gtct

tgga

aagg

atgc

acac

tgat

catc

tcaa

taag

acag

gggc

tggg

ttggg

ggca

gcag

agga

ggcc

aagc

acat

tcac

ctgc

accc

ctag

tacc

tggg

cagc

ccat

actc

caat

gtgg

ta

1673

3264854

—NO

ctcc

acct

ctttt

tgtg

cgag

ggcg

gcct

c1674

2701275

—NO

acttg

ctgg

aaaa

agta

catg

ctct

cc1675

3017578

—NO

tatc

tctg

atgg

ttgct

agtg

aaca

ttaag

ccct

caat

atttg

tttaa

tcag

tgct

atca

aagt

ggttt

aaat

ggat

gtag

tctc

cagg

ggtc

tctg

1676

3625878

—NO

ctac

ttcag

tgag

tggg

acttt

agcc

tgag

ca1677

2438152

—NO

cagc

tccc

tgag

atag

atgt

aaat

ccta

agca

ttgtg

ggtg

ttttg

gtttg

atgg

gact

ggat

tgaa

agat

ttaca

gact

taaa

ttgta

aagg

aagg

taat

ttaga

gaga

ggaa

ggaa

ataa

acat

tatg

ttggt

ttggt

tata

acca

ctgg

cttg

tctc

cact

gaca

tggc

ctgg

gggt

gagt

ggtg

tattt

gcaa

agct

ccttt

cagg

tct

gcat

taat

ctct

ggca

ttagt

tggc

tgtg

accg

atta

gcct

ccca

gtta

aagt

atgt

agtc

agttc

ttagt

gatg

gtaa

atgg

gtta

ctga

ggcc

ttctta

ttaca

tcca

atta

tgag

gtga

ctat

ataa

tttat

cttg

caaa

ctgt

tgag

tgtg

ttcta

aaca

gtat

gctg

tggg

ggcg

ctat

cact

aatta

tgct

gga

1678

2786550

NO

gtac

ccag

gagg

tttgg

catc

actc

aaga

ccct

caga

atgc

ttcct

ctgc

tttaa

atgc

ttgga

gtgg

ctct

ctgt

ccaa

actg

tatta

cccc

atcc

aaac

taaa

tca

cctc

tcac

tatg

tgga

tgaa

gcaa

acaa

caga

tcttt

tgttt

cgaa

atga

tttca

tgtta

acta

tattc

cagg

atat

taag

atct

tact

taag

gaaa

ctgc

tttgc

OO

agtg

ccag

ggat

ctaa

gcta

tata

1679

3122495

ANGPT

YES

cagg

gaca

gccg

gcaa

aata

agca

g2

1680

3252241

___

NO

cttc

tccg

cacc

acat

cgcc

ctta

ctct

aaaa

ttgac

caca

taat

tgga

agta

aaac

actc

ctca

gcac

aagc

aaaa

taat

a1681

2806568

—NO

agag

cact

caat

tcga

ctat

ccgt

ccag

ctttc

acag

aattt

acttc

tgag

ccca

caag

actc

aaat

tgta

taag

gata

gagt

ctgt

ttcat

tcat

caac

atat

ccag

cacc

tgac

atag

tttta

catg

gcac

agag

tggg

tgttc

aata

aata

tttgt

caat

gattg

aaca

gaaa

ttttc

agca

ccaa

atga

aaga

aaca

catg

acttt

gaa

caac

ggca

cgag

aata

ccaa

ctgt

ttgat

tatg

caac

gaca

ggat

ctttt

ggc

1682

3385452

NO

agttc

ctaa

atgg

gaac

actg

cctta

tgga

1683

3968192

—NO

gatc

aacg

ctta

attc

aaaa

ccag

gctg

taga

agaa

gaag

aaga

agag

ctaa

gaag

gttc

ttagt

gctg

atgg

ggag

aaga

gaag

gttc

tgga

gctg

tgc

catc

cccg

ggtg

gaaa

gagg

gaat

gtgt

tcttt

cttc

ccttg

acac

ttctg

tgca

gatg

aatc

aggc

agga

atca

agag

cggt

tg

1684

2397794

—NO

cttc

tgat

cacc

aagc

caca

tgtg

atga

ctcc

tggg

ccct

tcttc

ctgg

gaca

actg

cacc

agct

tcta

atca

gctc

gccc

atct

cagc

ctga

cccc

tctc

tgc

agcc

tgaa

gtcc

agac

tctc

tagc

ctgg

cacc

atag

tcct

ttcct

tctc

tctg

acct

aatc

atta

acca

taac

cc

1685

2412877

ZCCHC

YES

cgat

gtga

cattg

ggga

tgct

tcca

gggg

aagt

ttatc

ttcat

atg

11

1686

2904959

MAPKl

YYEESS

gtgg

gctg

tatc

atgg

caga

gatg

ct3

1687

3367083

NNOO

acag

actg

acag

aggt

gcat

ggtg

gag

1688

2762520

NO

tttac

catc

gtttc

attc

catc

catc

c1689

3463535

NO

tgcc

tgta

gctc

cata

cctg

tata

atca

acag

ctat

taaa

tatc

tgct

aagc

aaac

taaa

ctaa

gcat

tttca

aaag

taaa

cttg

tgaa

acct

gatg

gattt

cagt

agt

tgac

atca

gcat

ctac

ttttg

ctga

agtc

agta

gcct

ggac

atta

tttat

gaca

ctta

tttttt

tttcc

catc

ttgcc

ctta

tcca

ttcat

tcac

caag

ccttg

ttgag

ttta

tcttc

tgag

tatc

tcat

tgcc

atca

cacc

aatc

tagg

acac

catc

atct

ctta

cata

ggtg

atta

caat

agcc

tcca

cact

ggcc

tccc

tgtc

tccg

tttag

ctc

atct

ccca

atat

atttt

ataa

aaat

gata

ctgt

tact

ttctc

tgct

ttaat

ggct

tacc

atta

ccttt

aaat

ggag

tctg

aatc

agtg

gtct

ccaa

aggg

gggt

gata

tat

aaga

taat

ctgc

tagg

gtgc

agga

ggaa

aata

ttgga

acttt

tattc

atat

ttacc

ttttta

tttga

aaaa

cact

aagg

catta

atat

ttaaa

agct

acta

ctgt

gtaa

tagt

tattt

agtc

attc

cttc

tttgc

tcta

tgtg

tcag

atgg

tcat

ttggt

acta

aagg

tgtc

ctga

ggga

agca

tgct

ttgttc

acttt

ctgc

atgt

tgca

caat

acta

taat

ttgaa

tgtc

catc

tatg

cgga

tttat

gagt

tatc

tagt

ttaac

tatta

caaa

atat

gtaa

gtct

ggga

ttagg

gaat

ttgtg

gaga

aaat

caag

tgttt

aact

gcaa

ataa

gatc

acat

tgttg

ttcag

ctgg

taag

atat

acaa

aatc

aaat

ctgt

tctc

atga

atta

agaa

aaat

tacg

ctga

ttttg

aggt

tttaa

gtga

aact

tttta

aaaa

attc

tcat

tttttt

gtaa

ggca

tccc

tttct

gcttt

gata

gcca

ttaaa

aatc

aaat

attc

aaac

tgat

gtta

gaac

taga

tcttt

gaat

ctct

gtat

caca

cggt

gtta

agat

cttc

agaa

ataa

tgaa

gcat

attc

aata

tttta

1690

3533262

—NO

tggg

ggag

ggag

gata

ctac

tgag

caa

1691

3651809

—NO

caaa

gatg

agag

gtgc

gaag

ttgtc

caag

tcca

acag

ctca

actg

aact

ttcct

aagt

ggaa

ttgtta

1692

3719905

MLLT6

NO

ggttt

tgca

tctc

attta

cttc

tcca

ttggt

tcag

gata

aag

ctga

gcgt

gcca

tctc

ccag

tggc

c00

1693

3744442

—NO

1694

3994048

—NO

gcaa

gcag

cttg

tcag

acgt

gcat

gtgg

tttgg

a1695

2566874

—NO

ttccc

tcca

aagt

ggaa

gtga

gctg

gaga

gatc

tctg

ggtc

tgaa

agtc

acct

gcta

tgttg

gagg

aggg

tcag

gcttt

ttgag

gact

actc

tggt

caag

gtc

tgca

gact

tgct

tccc

tcct

ttaac

ccaa

atct

tatta

ttatg

gcta

caca

tgtg

ccac

acat

tata

gctc

caga

tact

cacg

caag

gttc

1696

3788902

—NO

agttt

ctttt

ggca

ggtg

gtcc

agaa

1697

2684832

VGLL3

NO

aaca

caac

cattt

acga

tctc

agtc

agca

gattt

actc

tact

caag

gaaa

aaaa

gaaa

caat

ctta

ttgga

agca

gatg

ttgac

actg

tgtc

agtta

ttgaa

gac

ggaa

ggag

ttcac

ttgag

ccat

tgca

gtta

caaa

gggg

tattg

atgg

cagt

1698

2808743

—NO

ggcc

aact

gtca

agat

gtttt

gaag

gcca

atct

ggaa

gtat

atgt

taaa

ataa

agat

gtgc

ataa

tttct

aact

gagc

aact

ctac

tttgt

ggta

tttat

ccta

gag

aaac

attc

acaa

ttatg

ccca

gaga

gata

tatg

tagg

gtat

ccct

tgct

acat

ggttt

ataa

caaa

aaaa

tata

ttagc

caac

tagg

gtcc

atta

gg

1699

3311746

—NO

tttcc

tcag

tgca

ttcttg

gtgg

tgag

attg

attg

gtga

gcat

cgta

taac

ccac

tctg

ggag

cata

gcct

atttg

tattt

gtgt

atgt

ctat

acttt

gtga

ggttt

agcc

cact

tc

1700

2398939

—NO

atga

aatg

gtttg

gaaa

ggag

cctt

1701

2948399

—NO

agag

ggcg

atca

ggtc

tcat

tagg

cccc

aggg

tgtc

tgag

gggt

gatc

tctg

ccag

tggc

ggtg

ggca

aggc

agaa

gagg

cgtc

tgct

gcag

tgga

agga

tcat

gaca

gcct

gagt

taaa

ttcca

cctc

ttctc

agct

gtga

ggtc

ttgag

taag

tgat

tttgc

tact

ctga

gtct

tagt

tact

ttg

1702

2974

531

NO

tctc

atttt

gattc

tggc

agtg

ggcc

caaa

tgct

aagt

gtct

tgcc

caaa

gtag

aaat

ttcca

gttg

ctac

ttcca

tggt

gtgc

cgca

cagg

caat

ggct

gagt

tct

t

1703

3385

006

CR

EB

ZN

Otc

tgga

tgat

tagc

acat

ggat

aaag

gaga

tttct

ggaa

tata

aaat

ggat

tgttt

ttgaa

atttc

tagg

tttgg

ctct

attta

ctgt

aatg

gttg

aaaa

caat

ttagt

Fat

ttggg

tgac

ccttt

tgttt

ttcttc

taaa

tgtg

cctc

tggt

aaaa

taca

gaac

taga

ctaa

agat

gtag

ctttt

taat

atttg

tcttt

tgat

ggtg

gcag

gagt

tcat

aca

ttaat

tgaa

ctaa

caca

tcat

atttt

gacc

tact

atttc

tatc

atat

tgac

ttact

gtttc

tgca

cttc

tttga

ccag

actta

tc

1704

3777

967

—N

Ogc

gagt

gact

ccgt

ttcttt

ggac

ctgc

ggttg

agct

ggca

gcag

aatg

gagg

ggtc

cgag

aaac

gggt

gagt

gtga

atcc

cttg

caga

aatg

ctct

ctgg

gggt

ctgc

ccttg

aatg

ttagg

cggc

atga

caag

tcaa

atgc

agtc

cacc

aggg

tc

1705

2446

212

TO

RlA

IY

ES

atgg

ccga

cagt

ggac

ttagg

gaac

ctca

agag

gP

2

1706

2527

475

—N

Occ

atttg

agat

gttc

tccg

aggt

gg17

0731

1089

2—

NO

ttggt

ttcaa

atgg

acag

cagc

aaa

1708

3229

044

BR

D3

NO

gatg

tttct

ggta

atca

tgga

ccct

tctc

c17

0935

1854

9M

YC

BP

YE

Sca

ggac

cagg

ttctc

ggttg

tcat

ctcc

taag

ccaa

agac

tctc

ccag

ccaa

tagg

tcta

gccc

atcg

ggtg

ctag

ttctc

cacg

ctcc

tcct

cacc

acat

gat

2aa

aaat

ctac

ctca

aaaa

agta

ctgc

tcct

gtta

agac

aaag

cttg

atcc

tcct

cggg

aacg

ttcta

aatc

agac

tctta

caca

cttg

atcc

agat

accc

tccg

caa

gaag

aaaa

tgcc

cctc

acag

aacc

tttga

gagg

acgg

tcaa

cgtc

acca

aaac

caaa

atca

gtac

caaa

ggat

tcta

caga

ttccc

ctgg

atct

gaaa

ata

gagc

tccc

tctc

ccca

tgtg

gtac

agga

aaac

ctcc

acag

tgag

gtgg

tcga

agtc

tgca

cctc

aagt

a

00

1710

3701324

—NO

caaa

ttaca

attc

aggt

tctg

tttga

ggtg

ctcc

tgag

aaga

ggaa

aaga

gtca

gaaa

ccta

caca

aaga

tgta

taga

agat

tagg

tcct

gaga

g1711

2941831

—NO

ttgcg

tttac

atga

cttg

agtg

gcct

gtca

gtcc

cgct

agta

aagt

ctcc

tcat

ccat

ccac

tctg

tttaa

acaa

tcaa

actc

tgaa

acct

gtgt

ctcc

tgga

ccat

ccta

taat

ccct

aaaa

tagg

ctgt

tatg

ctttt

cacc

tctg

ccct

actc

tgtta

gcac

tacc

ttact

tattg

acct

ctttc

aatc

aaat

cgtta

tcta

aagg

atac

ctgt

aact

caga

tagg

ttgcc

tact

gggc

ctgt

ttagt

ttta

1712

3403963

NO

tttttt

ctgc

acta

tggc

ttggg

ccc

1713

2337265

Clorfl7

YES

gaaa

ggca

acaa

caag

cagt

caca

gggg

5

1714

2774211

___

NNOO

catc

agga

gtgt

ggat

tctg

ccat

tagt

accc

aaca

gatc

aatg

ccca

gtgt

ttc1715

3626362

ALDHl

YYEESS

gcttc

agaa

aggg

gacg

tctg

ttgga

taag

cttg

caga

cttg

gtgg

aacg

ggac

aggg

cA2

1716

3760869

...

NO

gagc

gtct

ctcc

ttcaa

atac

ctgg

atttt

tttttt

tttgt

acac

tggt

tcat

agat

cggc

acttg

acttt

gaac

ctgg

cacc

aaaa

ggca

caat

atct

gata

ccct

gtac

aaga

gcta

ttaga

gatg

ctgc

cata

tgga

tggg

caaa

actg

agcc

aatc

ccac

ttagg

aatg

gaag

gcttg

gaca

tgga

aggg

agga

tata

aacg

agg

agttg

gaga

aaaa

cgca

agcc

cagt

ttttg

ctag

agtg

gaaa

tgaa

agtg

ggaa

tgag

ggtc

ttgttt

ttagt

cctc

taag

gacc

agga

agca

atttt

aaaa

cttc

cttg

gtttt

tctg

aaag

cagc

atat

tcaa

aatg

ccag

caaa

aact

ccta

acaa

ctgc

aaaa

ccaa

aaga

ggat

caaa

gctc

acca

acat

ccct

tctta

ttgct

gaaa

ggct

ctaa

aattc

agga

tgcc

ctgt

tccc

ttgta

aaag

ggaa

aata

atta

agtc

tgat

ttatg

gtaa

tcat

acca

catc

acac

ttcta

aaaa

aata

ttcaa

gtg

tgtg

acca

gggg

acgt

ttgac

acca

tt

1717

2772067

—NO

cctc

aaag

tgtc

tagg

aggc

ggttt

gata

tgca

gact

aaag

tgag

a1718

3350159

—NO

tttac

atca

tggt

gtgt

gaca

aaac

aattg

cttc

cccc

tcct

ccct

gccc

ttccc

cacc

cctg

acttc

taag

ataa

cta

1719

3946034

—NO

aggt

ctgc

ccat

ccca

aacc

tggg

t1720

2699092

—NO

gcttc

aaac

attg

gccc

ttcac

gtac

aaca

aact

ctat

cattc

gatg

tatc

aggg

cgag

caaa

ttcct

acaa

caac

aaca

cagt

taaa

gaaa

atgg

attc

aga

ccta

ccac

tata

taaa

acta

cact

tgac

ctaa

gtta

ctat

aattg

tgca

gaaa

atga

ttattc

tgct

gact

aaca

ccga

attta

atac

caaa

aaag

taac

ctgg

agca

tatg

ttaat

gcct

tgtg

catta

agag

ggtg

tggg

gcag

tggg

agta

ggga

agtg

ggag

ggga

tgga

aagg

tgag

ggag

ggta

ggaa

acca

caat

aca

gcct

cata

gtaa

tattt

aattt

tcta

aatg

tcac

ttattt

tcca

aaag

taaa

acat

taaa

ttata

aatc

acaa

ctaa

ttaga

aagc

tgca

aata

ttgat

atat

aaaa

tca

gtaa

ctta

gagc

ctgc

atgt

tatta

cagc

catc

ta

1721

3027187

NO

gttc

acgg

cagc

tccc

aaca

ggtc

tgag

gtaa

gacg

ccgc

tatta

tcct

cgttt

gctg

ggag

aaga

ctcg

ggct

taga

gcct

ctga

ttaca

cagc

tgca

ctct

aacc

atttc

ctaa

ta

1722

3496668

NO

tctc

atgt

acct

cgta

gtat

acct

acta

tata

ccca

gaaa

aatta

aaaa

ttaaa

aact

aaag

aaag

aaat

aattg

caaa

atgt

aata

atgt

ctttg

aggg

gaaa

ataa

aaac

ttcag

tgaa

atac

tcta

agag

gggt

ttgat

gcag

agct

gggg

gatg

tggg

aaag

taga

gata

ggaa

agttg

agga

ggga

ggga

tggg

ttaca

gtttg

ccaa

ggac

agaa

ttact

tgag

aggg

tggg

agca

ggac

acac

atgt

cagg

gcct

ctgg

aaca

ggaa

gagg

ttggt

ttatg

gcag

aaat

tgaa

agaa

tgct

ctca

taca

cagc

tcac

tttcc

tcct

tgct

ttttg

tctg

cata

gcat

tattc

aata

tgta

gcat

aata

taag

ttgaa

atca

tata

tcac

ctttg

tggt

cttc

tccc

acca

gaaa

tcag

gcat

tatg

aagg

caga

aggg

caga

ggta

tttgt

cgtg

tgtg

tgtg

tgtg

tgtg

tgtg

tgtg

tgtg

tgtg

tgtg

tgtg

tttga

ctttt

gtat

ttttg

ctgc

Ocg

tattc

ctgg

tacc

tgga

atag

cact

tggc

agac

aaat

gtat

gcaa

agtta

ttcaa

atcc

agtg

ggac

caga

ccac

agtg

1723

3718614

—NO

cagt

gggg

atgt

agaa

tgtg

tcca

aa1724

3759098

—NO

gggg

cagc

acag

gtac

tctg

atttt

gggg

ccac

gagg

gcca

aatc

cgcg

cctg

cacg

tag

1725

2721510

—NO

tattc

ctgg

acta

tagc

cgct

gatc

tcat

tgat

gccc

ttcttc

1726

2938424

—NO

ctca

agag

tgaa

cccg

gaaa

ggct

ccta

agga

ggtc

cctg

cctc

agtc

cagg

caag

gctg

tggc

ctag

acga

ggtg

gcg

1727

3606484

AKAPl

NO

tgct

gctg

cccg

catg

ggat

gcgc

aggg

gagg

cgtg

ggga

tccg

cagg

aggg

tggt

tggg

atac

accg

gata

cctc

tgct

ctca

ttgct

tgttt

gcaa

atg

3ct

ctat

ggac

atttg

tgtg

ctaa

atcc

ta

1728

3750237

—NO

ttcac

ccac

atac

aaaa

tagt

gcgc

gtttt

ggct

acttc

agcc

tcttc

ccttc

tcta

gaaa

taac

tcct

ccttg

tact

tagt

aaag

gcac

acat

tcac

ttcaa

gagt

agg

1729

3320010

—NO

cagg

aggc

ccga

ccaa

aagc

agat

caaa

tagg

agtg

acag

agttc

agag

ctgc

ctgg

gaca

aagt

tttaa

atttt

atttt

cact

gcaa

ccca

tagg

aaga

taaa

cattt

tata

tcat

gacc

cagc

acac

aca

1730

3907649

—NO

agga

atgg

gccg

catg

gact

acct

gggg

gtcc

ccaa

ggcc

ccag

ctcc

tctc

ctttc

cgcg

ccttc

tccc

aacc

tttat

tgca

gcgt

ctcc

tccg

gcga

gac

gagg

ccgg

gctta

gaaa

aagg

gcag

cgaa

gacc

cagg

ggcc

aaac

tggc

actg

agga

gctc

tggt

ctct

gcgc

ggcg

gggc

gccc

tctc

cgaa

tcag

cccc

aaca

ggcg

tggc

ctcc

gggc

ttcag

gcag

cggg

gtaa

gggg

ccag

gaca

cggg

caca

gggt

ctgt

atgt

aaac

ggtg

acag

cggc

1731

2546923

—NO

ggct

gtgt

cacg

tgga

cagt

gtca

catc

tgcg

ggtg

ggga

taac

aagg

cacc

tgag

tgcg

tgaa

ggag

ga

1732

2788764

—NO

ccat

ggga

acag

tcttg

cagt

gatg

gacg

gtttc

catc

cccc

atca

ctga

cgcg

ggaa

taac

tgtg

ctgt

1733

2886332

___

NO

ctttt

ggca

aaaa

tgcg

ggcc

atgg

ggtg

tcaa

ag1734

3307785

—NO

aact

tcaa

actg

tgct

catg

tggg

caca

gaag

catc

gtgc

aggg

ctgc

actg

tcac

cagc

ccca

gcag

ccac

aggg

cagt

ttgtc

acca

gctc

cctg

aga

atca

actc

cagt

gtga

tgga

ggtg

accc

1735

2339825

NO

tcttt

aagc

gaga

agta

gatg

tggg

gagg

ggttg

ttgca

ttttta

aaga

ttcct

gtat

tagg

ccgg

gtgc

1736

2922550

___

NO

gtga

acttt

gtac

ttacg

tgtg

ctttt

gtgg

tagc

aagt

atca

tcttt

ctgt

ttcct

tttag

cattt

ttggt

gtac

tggt

cta

1737

3319874

IPO7

YES

tagc

gcac

agttt

gaca

tgtc

aaca

ag1738

3571362

—NO

tggg

tact

cgag

cact

gaag

cattc

tcat

cact

tccc

atga

agac

acta

atcc

catta

aact

aggc

attc

ctct

ttccc

tgag

gttc

gttg

atag

ttgta

tcttt

tgt

cattt

ccca

tagt

ggga

aaac

taag

gtcc

gtgg

aggg

ggat

gtga

atcc

ataa

tttct

cttc

aaca

aaca

ggca

gcag

agcc

attg

tgga

atttc

tagc

ctaa

gcca

taag

atttg

tggt

ttgtc

ctga

tgta

agtg

cattc

actg

1739

2562256

—NO

acag

gcgg

gtat

ggta

atag

caat

ctca

ggag

ggct

cttc

tgttg

ctgt

gtag

aaaa

tgaa

ccaa

gtag

cata

gaat

cgtg

acca

gcttt

ccac

acct

ggct

gga

gcac

tcct

gggg

ccttc

agta

ggga

cagt

tac

1740

2599272

NO

ggaa

gtta

ctgc

ttccc

ctgg

tgtc

tgttc

ttctg

gcttc

agct

tcgc

tggg

gatg

gattc

1741

3019543

—NO

gtgg

ccttt

tagg

aact

gtag

agta

actta

atat

aaga

gaca

ttattt

ggtg

ggca

gaat

taag

atct

tggg

agcc

attg

ctgg

tgca

atcc

tcac

ttggg

aaaa

tttaa

caaa

atat

agtta

gacc

ttttc

cagg

tctc

accc

attc

catt

1742

3316144

TMEM8

NO

gagg

gcca

cattc

ggag

cctc

cgtc

cact

ccag

tttta

tcag

ctttt

gcct

tttgc

acgg

agtg

ctaa

acaa

attc

tagc

tctg

tgttt

ttttc

ccat

tccc

agat

tt0

acta

tcag

ttctc

ctta

aaaa

gtat

ctaa

gctg

ttaca

gtag

ctttc

ccttc

acttg

attc

tattg

tgtg

ttttc

tatg

tttgg

aata

atta

cacc

caaa

tatc

taga

tattt

tctc

ttcac

cgca

ttttg

taaa

ta

1743

3808909

TCF4

YES

gtct

atgc

tcca

tcag

caag

cact

gccg

acta

caat

aggg

actc

gcca

ggct

atcc

ttcct

ccaa

acca

gcaa

ccag

cact

ttccc

tagc

tcc

1744

2360953

NO

acat

tcta

tcag

agag

taca

tgat

atca

ccat

gcct

tatc

attg

gtga

agtta

acct

tgaa

cttg

gtta

aggt

gctg

tctg

ccag

gcct

cttc

actg

taaa

gtta

ctgc

ttttc

cctc

ttcat

actc

tgttc

ttt

1745

2458

084

WD

R26

NO

cagc

tgttc

tagg

atct

tgtc

atttt

tact

gaaa

gtct

cgtg

caca

tgtg

aagt

gccc

tctg

agttt

aagg

tttgg

ttaat

actg

gtat

atttt

tata

agat

tgaa

attg

tgt

cccc

atct

ttaac

ttaaa

cattt

tcat

tatc

aggg

tcaa

tgtg

ctag

aact

gaat

tgta

acat

tttta

ggca

caga

tgga

aaaa

aatg

ttattg

gctc

cttg

aaaa

tgtg

tgtg

tgtg

gcga

gggg

aata

gatc

caca

aaag

catg

tatg

tact

taca

aacc

aagc

tgta

gaga

tcaa

gaaa

agaa

ctta

agtg

ttgat

ctca

agat

ttcta

aattg

tcaa

gattt

acat

ggca

ttgtg

gtgg

aact

agtta

ac

1746

2775432

—NO

tgga

gacc

agat

aatg

gatg

ctgg

caag

atct

ggga

atca

aagc

catg

gaaa

gggt

gcca

ttggt

cag

1747

3577885

DICERl

YES

taga

taat

atgt

taat

gggg

tcag

gagc

ttttg

1748

2413468

TMEM4

YES

gctg

gagg

atag

ttgca

agta

ttgttt

ggtc

agtg

ctat

ttcta

ccca

tctg

cacc

acag

tattt

ataa

ttttc

agca

ggat

tgat

ttgttt

catc

ctat

acag

tggc

tQ δ

1749

2478883

NO

tgaa

caga

cctc

aatg

tcag

acaa

gcca

gggg

agcc

tgc

1750

2783808

—NO

atat

tttta

atgg

tgtc

agcc

aggc

aaa

1751

2406967

___

NO

ctcc

tgtg

actc

agag

ccct

cggc

tt1752

2436718

UBE2Q

NO

tgct

gtat

ttgga

tctc

acgc

tgcc

tctg

tggt

tccc

tccc

tcat

ttttc

ctgg

acgt

gata

gctc

tgcc

tattg

cagg

acaa

tgat

ggct

attc

taaa

cgct

aagg

1aa

aaaa

aaca

aaca

caga

actg

tttca

agta

ctca

agac

tgac

ttaca

gacc

aacc

aacc

acct

tgct

ggaa

ccct

tgct

agca

ggca

ttctta

taaa

agaa

act

ttcga

gcct

cctta

tattg

ctgg

aaac

tcag

ctgt

gctc

caga

ctag

agcc

tcct

tacc

tatg

ctat

gga

1753

2663594

—NO

ggca

tctta

tttca

cgca

ccac

aggc

ccttg

ttcttc

ccag

atgt

cagc

aggc

tttct

ccaa

taaa

tgct

tcttc

atttg

ctgt

tgcc

cttg

gaat

catc

ccag

aga

tttta

aacg

gctg

tgtg

tatg

tttca

tggg

gaag

tctg

tggc

ctcc

ttaca

ctgt

cctg

caga

actg

gcac

ctcc

ggct

gtttt

1754

2854791

NO

tttag

aattg

actg

agga

gcgg

ccgg

gtgc

ggag

gctc

acat

ctgt

aatc

ccac

acgc

cttg

ggag

gctc

tgag

gcgg

gtag

atca

cctg

aggt

cagg

agttt

gaga

ccag

cctg

gcca

acat

ggcg

aaac

cccg

tctc

cact

aaaa

atac

aaaa

atta

gcca

ggtg

cagt

ggca

caca

cctg

taat

ccca

gcta

ctcc

gaag

gctg

aggc

agga

ggat

cacc

tgag

ccca

ggaa

gttg

agac

tgca

gtga

gctg

agat

tgca

ccac

tgca

ctcc

agcc

tcag

tgac

agcg

agac

tgtc

tca

aaaa

aaga

aaaa

agtg

actg

agga

ggaa

gagg

ccag

gtgg

caaa

tgga

acag

aatc

acca

aagg

gtga

acag

gact

aagg

caat

gtag

tgta

tgg

ctca

gcta

cgtc

agag

tgga

aaag

gtgt

tatta

gagc

agaa

acta

tggt

ccct

gcgt

caca

ggga

agca

acct

acag

agaa

gcag

cagc

tccc

caag

agag

gaga

gata

agaa

gcca

gaag

cctc

agag

tgaa

caat

tgtc

cta

1755

3350791

SIDT2

NO

tcag

agttt

ggtg

tatta

gagg

aact

gcca

gttg

ttcat

actg

gcta

ggca

gggc

ctta

cattt

gagg

ggag

aagg

gtga

gaga

ttgag

ctgg

gtgg

agga

ggac

atga

aggc

ctttg

ggtg

ccat

κ1756

3447872

KRAS

NO

catc

ttcag

tgcc

agtc

ttggg

caaa

attg

tgca

agag

gtga

agttt

atat

ttgaa

tatc

cattc

tcgt

tttag

gact

cttc

ttcca

tatta

gtgt

catc

ttgcc

tccc

tac

cttc

caca

tgcc

ccat

gact

tgat

gcag

tttta

atac

ttgta

attc

ccct

aacc

ataa

gattt

actg

ctgc

tgtg

gata

tctc

catg

aagt

tttcc

cact

gagt

caca

tcag

a

1757

3709501

—NO

gtcc

agtg

cctc

ataa

catg

gtct

caag

ctct

taac

aaat

ggag

ccca

ggat

tcaa

aaat

ctga

actc

taat

aatg

gcttg

tcat

tctg

gtttc

ttacc

cttg

agg

aacc

tgtg

aggt

gtta

acca

acct

gtaa

gctg

cattc

cagc

actg

gcaa

acct

ggcc

tctc

aaat

atcc

agcc

aattc

taag

tttgg

tgcc

agga

1758

3606344

—NO

gaaa

aaat

tgtc

agttg

cagg

gata

cattt

ctca

ctaa

tgaa

gaaa

catg

gaaa

atat

ctgt

gtaa

gggg

atca

cgct

gtttc

ttaag

ttcag

atta

ttgga

aga

gggt

ggtg

atgt

aggt

gtgt

actc

ttcct

gagg

ttg

1759

3884906

FAM83

YES

ttctg

tctg

gcca

agtg

gttg

aaca

ctttg

atct

ggag

ttccg

aatc

ctgt

atgc

ccag

tcca

agcc

catc

agcc

ccaa

actc

ctgt

ctca

cttc

caga

gcag

cD

aaca

agttt

gatc

acct

cacc

aacc

gaaa

acca

cagt

ccaa

ggag

ctca

ccct

gggc

aacc

tgct

gcgg

atgc

ggct

ggct

aggc

tgtc

aagt

actc

cc

1760

3919041

SLC5A3

NO

ttgga

aaca

gaaa

cgag

gctta

ttgct

attg

caga

aatc

ccaa

actg

gcaa

aggc

cagt

atat

atgg

tattc

cata

atat

aacc

agct

tttga

aattt

atgt

gttt

ggat

tagt

gcct

tctg

gtta

ccag

tattg

actc

tgct

agttt

gcac

ctttc

cgttc

tta

1761

2847683

—NO

ctgg

gagg

ctttc

agat

gcag

catc

cacc

aagg

aata

cacc

gact

aaca

caca

tgac

agcc

tgaa

ctag

caac

ctgc

atca

acac

ccct

gcag

aaaa

gca

gtgc

atttc

aact

gctc

attta

ataa

gtat

ttgaa

ttcat

aatta

caaa

acat

cttc

tgta

atta

aacc

acca

tatg

cattt

aaaa

tattt

tggg

gaca

aaga

gtag

caaa

gaat

tata

ttgga

tattg

acta

aaaa

cact

tatg

aata

tcaa

taat

ttgct

cctc

ctcc

ctttt

catc

atag

actc

tttac

aatg

atac

tgac

cttg

gggt

tg

1762

3776975

NO

tttgc

aacc

caac

ctgc

tgga

agtg

caaa

gttc

agac

cagc

agca

agaa

ctct

tgcc

ccat

gcttc

tgct

gaca

t

1763

3543413

RB

M25

YE

Sat

ctcg

aacc

agtg

gagc

gcac

tcgt

aacc

tgga

tccc

agaa

ggtc

gcga

aggc

agta

ccgt

ttcct

cagc

ggc

1764

3653407

NO

ttgag

tgtg

gtag

tgtc

cgtc

tgta

gtcc

cagc

aact

cagg

aggt

tggg

gcag

gagg

atca

cttg

agcc

cagg

agttc

aagg

ctgc

agtg

agct

ataa

ttgc

acca

ttgca

ctca

agct

cagg

caac

agag

tgag

acct

tgtc

tcaa

aaaa

aaaa

aaaa

aaat

ttaaa

caag

cgac

agta

atat

ttcat

taga

aatg

tgat

gaat

gcta

tgaa

ggtg

taga

ggat

gtct

ttaga

atat

ataa

ctgg

gagg

gaga

ccttt

tgag

ttaag

gcag

gtgc

tggt

cagg

aaag

tcct

gagg

aagt

taca

tttg

gattg

a

1765

3670580

—N

Ogt

gaaa

gact

aaac

agac

gact

tcaa

aact

ctca

tcca

acat

ccaa

gagt

tctg

ccat

ttcca

agat

tcag

caat

cctc

1766

3767260

___

NO

tacc

agtta

gtac

aaag

atca

cagc

caat

atag

aacc

taaa

agta

ttcac

aatg

aaaa

tgac

aatg

tagt

tgtc

gtttt

gagc

tgca

tggt

actta

aatc

tg1767

2456432

___

NO

cacc

tgct

ccga

gggt

cagg

gcta

agtg

gtttg

agca

agtg

gcaa

gctc

acag

gtcc

agttg

gctg

aggg

cctg

accc

atga

cgat

ccat

tt1768

2750681

___

NO

tatg

acac

tgaa

tacg

ggaa

agtg

atgg

gagt

gagg

ctgg

ttaaa

atttt

tcac

ccac

gcag

tctc

cctg

tgtt

1769

3071991

LOC653

NO

cacg

tggt

cact

gaca

ctcc

catg

gc852

1770

3436046

ATP6V

YE

Sac

tcgg

atcc

gcac

caac

aaat

tcac

cgag

ggat

ttca

0A2

1771

2383133

—N

Otc

agcc

ctgt

gaag

atgt

cattc

catta

tcttc

tgtc

ttcta

ttgttt

ctgt

ggag

atgg

tagc

tctc

agac

aaat

tgttg

gttg

ctcg

tttgt

acat

actc

ccca

ctcc

Oca

tcct

gccc

tggg

tact

ctaa

cattt

tttca

ctttg

tgttt

agttt

cagc

agttt

taag

ataa

cgtg

ccta

ggtc

gggc

1772

2434773

FAM63

NO

acttt

ccag

ccgc

agag

tagt

gcag

A1773

3338526

PPFIAl

YE

Sgt

ttgga

gcaa

tgat

cgag

tgat

tcgc

tgga

tcct

gtca

attg

gcct

taaa

gaat

atgc

aaac

aatc

ttata

gaga

gtgg

tgttc

acgg

agca

cttc

tggc

ctta

gatg

aaac

cttc

gact

tcag

tgca

ctgg

cact

gctg

ttaca

gatc

ccga

cgca

gaa

1774

3671856

KLHL3

YE

Sca

ggca

gacg

cgag

tgtc

tcgg

ccat

acaa

gatc

agcg

aatc

atca

6

1775

3060641

NO

ctcc

catg

gctg

gata

aacc

aaat

ctga

taca

tcca

cattt

aagg

ttgttt

tcca

agttg

gtttc

cata

aaag

gcct

ttaac

aata

atag

gcttt

taac

aaca

aaaa

ggta

tccc

tccc

atca

caat

gaga

gcttg

atga

gggc

tcaa

aagt

gact

tcaa

aaac

tgta

aata

atta

ttttc

cttg

gacg

gcttt

aaaa

acag

ctac

tgat

agca

aatc

agaa

acac

taaa

gaaa

aaag

acaa

taag

gaaa

cagc

tgttt

gtct

agtg

aatc

cata

ataa

atac

caat

ttgag

gcta

taga

ttaca

aagc

caaa

atat

tctta

tagg

aaag

ttaat

gttta

tattt

acaa

tccc

atgg

acta

aaaa

aact

gtct

aata

tctta

aaga

ctga

gtct

acct

ttattt

aaca

ttgttt

atac

acaa

aga

ccca

aggg

atgg

taga

attc

ttgat

ccttc

tgga

caaa

agca

tagt

gaga

gggg

actg

aaat

taac

aaaa

aggg

aaaa

ttaac

atta

atct

caaa

attc

tacc

catc

gttg

tctta

aaat

gatc

aaga

ctca

gcta

catc

tgag

aaaa

agga

aaag

gatc

agaa

gtga

aaga

aatc

agaa

gcca

gtaa

ttaaa

aaaa

tcat

aacc

ttgtg

tgct

ttcta

ctga

cggc

attta

aa

1776

3379

623

MT

L5

NO

ctgt

gcct

aggc

tgttg

acaa

ctttt

gctg

agttg

gaca

gaat

aaga

ctgt

gggc

catg

ctgc

ttgct

tcac

tctc

tggg

tgtg

atgg

atcg

gtga

gggt

gcag

ttgct

atga

ttgta

attg

gtca

tctc

atca

tggc

tgtta

acat

ttctg

gacc

aaac

aaaa

atga

cttc

agct

acttc

caga

ttctg

ctga

taca

ttaca

cagg

atga

tct

aaaa

ggct

acag

ttctg

aaga

tact

catc

tttct

tgta

atct

gggg

gcat

ctgg

tcaa

tagt

attg

cctc

tgtg

ctgt

attg

tgtc

taga

acat

tcaa

ggac

attt

gata

cttc

tcat

acttt

aattg

cgtg

ctct

ccca

gttg

cagc

accc

tctg

aggc

ttcta

tgtg

ttgca

gccg

atgg

gcat

ttgca

caga

gcag

cagt

catg

acag

cgttt

tcag

ggca

gcta

tttct

ccttt

tccc

ccttt

tcct

ctcc

cccg

gcttc

ccat

tctc

ctcc

tcct

ccttc

ctct

tctc

gtcc

cctc

ctcc

tcct

ctttg

ttctc

ctcc

ccct

gctc

ttcttc

ctct

ctcc

ttttc

ctcc

ttctg

tgtc

tata

ctag

atta

ttttc

aatc

agtc

acat

gtttt

tcttt

atttt

gaat

gtta

caaa

atat

ttctc

tattg

taaa

cggt

gtgc

cagg

aaaa

acat

gaga

tgtg

tattt

gtat

ttttta

tgca

cata

atta

ctta

atcc

aatg

cctc

tcca

ctta

attg

ggcc

tgat

ga

1777

3547548

—NO

ccag

tgttg

ggtg

caaa

tata

ccta

ggat

a1778

2779848

___

NO

atga

gaag

ggta

ttgga

tacg

atta

ggtta

gaag

ctcc

tagc

tcct

cagt

gaag

tggt

acat

aagg

gctc

tctc

tgc

1779

2869655

___

NO

ttcttt

ttcta

ccct

cact

gtcc

tct

1780

2964686

___

NO

tctg

agca

cacc

tgtc

caga

gagc

tc1781

4004181

DMD

YES

ccttc

agaa

ccgg

aggc

aaca

gttg

aatg

aaat

gtta

aagg

attc

aaca

caat

ggct

ggaa

gcta

agga

agaa

gctg

agca

ggtc

ttagg

acag

gcca

gag

ccaa

gcttg

agtc

atgg

aagg

aggg

tccc

tata

cagt

agat

gcaa

tc

1782

2432028

PDE4DI

YES

atgt

ctaa

tgga

tatc

gcac

tctg

tccc

agP

1783

2443375

F5

YES

tact

caag

atca

agaa

gata

acgg

caat

tata

acac

aggg

ctgc

aagt

ctct

gtcc

tctg

aaat

gtat

gtaa

agag

ctat

acca

tcca

ctac

agtg

agca

ggg

agtg

gaat

ggaa

acca

taca

ggct

gaaa

tcct

c

1784

2736714

NO

ttcca

gagt

ttgca

ggga

cagt

taga

gtca

atat

gaat

tctc

agaa

taag

cact

gcca

gata

gtcc

ggaa

gccc

tttac

aagg

aaag

tgac

atttt

tgct

gtgt

tttg

aata

gtga

acaa

gaat

gtgc

agga

agag

aatg

aaag

gata

tcac

tagc

agaa

gaaa

tgcc

tcttt

gtaa

aacc

atag

aaaa

taac

tctg

agttg

ccat

atag

gaca

tatg

agaa

tttca

gtgt

tact

gaaa

caaa

agct

tttgg

aaaa

ggta

tggt

gatta

aattg

ggta

taca

atct

gaaa

ggta

aattg

agga

caac

ttgtg

tgc

cagt

ttgca

1785

2969491

NO

ttgta

gctg

ttaga

aggg

atag

ttcta

caag

gtat

ccaa

atttc

ctaa

gtat

atttc

tttaa

atttt

ccttt

tattg

aattt

tctg

tttac

tggc

atta

gtct

cata

tcag

ttttg

gcta

ccttt

agct

gcttt

tgttg

aattc

tattt

aata

aagg

cact

gcaa

gtat

aaaa

ttatta

aaaa

taga

caag

caca

atcc

tttct

ctgc

taaa

caag

ctta

tga

aaaa

cctg

gtga

tacc

caaa

gagc

taca

aagg

aaac

tctc

acac

ttg

1786

3417650

RBMS2

NO

ctgc

acttg

tgga

acat

caca

tggc

aaaa

acag

gagt

tttttc

gcta

gact

tttttt

ttcttt

ttaac

ctta

ttaaa

aatg

agat

tggt

ccta

a1787

2586174

___

NO

ctttg

ctta

taat

gttc

tgta

gtgc

tgat

ggac

tgcc

tgat

tgta

ga1788

3777613

—NO

aatg

ctgc

aggc

atca

gtgg

gaga

g1789

3888166

CSElL

YES

tgac

atcc

cgtc

ttcct

atat

ggcc

ttattt

cctc

atct

ccttc

agcc

agtg

ctttg

ggaa

agaa

cagg

aaat

attc

ctgc

tcta

gtga

ggct

tcttc

aagc

attc

ttag

aacg

cggt

tcaa

acac

aata

gcaa

gtg

1790

2332

174

CT

PSY

ES

tgaa

ttctc

aaga

aacg

tgct

ggga

tggc

aag

1791

2684

865

VG

LL

3N

Oag

aacc

aact

acag

tcac

ctct

gcta

cctc

agca

tggg

ctgg

agcc

tttca

tgga

acag

taga

cata

gtgc

ccag

cgtg

ggat

tcga

taca

g17

9227

5642

6—

NO

aggc

aatg

gcga

tttta

ggct

ctcc

aggt

gatta

caat

atgc

aacc

atgc

tccc

aaat

gtct

gctg

taaa

ccaa

catc

tttcg

gagg

acca

gttg

aaaa

taat

atttc

tcaa

atta

atgt

gaaa

agtg

tttgc

tgttg

agttg

cggc

ctttc

agtc

ccgc

ctttg

ttctc

tact

cacc

actg

ttgag

ttgtg

gcct

ttcag

tccc

gcct

gtgt

tct

ctac

tcac

ctct

actg

cttg

ttttg

ctcc

tgat

tcaa

acca

gttc

caca

cata

ctaa

gccc

actg

tgct

aggt

ggcc

tgac

cgtg

gtga

atat

tattg

tgga

ggaa

ggac

tttgc

tgta

agaa

attg

cattc

ccca

aaac

tgaa

acca

tgat

attta

ctca

actg

aggt

aaaa

aatg

aaag

acta

aggg

ggac

tccc

aagg

gtca

ggg

caag

aata

aata

ccttg

gaat

atta

atac

ccat

ctca

tgat

gcct

gagt

gtaa

atgc

tcc

1793

3309131

C10orf4

NO

ggaa

atgc

taat

ttgag

cttc

attc

atag

ggga

acct

acta

tata

ttgca

tccc

tgct

ggttg

gaaa

ttatc

ttcat

ctct

ggac

tgca

ttgttt

agaa

aaat

gtta

at6

ggct

taca

attc

tgag

aact

ttattg

tgtg

gctc

tg

1794

3435688

ARL6IP

YES

ctga

cgga

tgag

caga

agtc

ccga

atcc

aggc

cat

4

1795

3544550

LOC731

YYEESS

tgga

aagc

tttga

agac

ggcg

gttc

tggg

223

1796

3737293

KIAA16

YES

tgaa

ggca

ttgtc

tgca

tttcc

aaga

agca

ccta

gata

aata

cattc

ctta

caag

tacg

tcat

ttata

atgg

ggaa

tcttt

tgag

tatg

agttc

attta

caag

cacc

18

agca

gaag

aagg

gcga

gtac

gtca

acc

1797

2769855

NO

ttagt

ttggg

tctg

atct

ttgttt

c1798

2914869

—_

NO

cttc

cttg

tgga

agttg

gcttg

atg

1799

2754682

NO

acag

agcc

cgag

ctttt

gtcc

tgca

ggct

caag

cttc

taga

ttcgt

cttc

tcgt

taat

gcgg

ggac

ggac

1800

2353146

—_

NO

ttcca

gcag

gcac

cgaa

aaag

ccct

gtga

gcttc

tctc

tgag

cggt

ggag

aact

gcac

atgt

atgg

atgt

tgct

gcttc

c1801

2685210

—NO

atat

ttgag

tgtc

ttattg

gact

tgga

acttc

cacc

agta

tctc

caga

atta

ttgtc

tgtc

tgca

g1802

2774664

—NO

agttt

tggt

tccg

acaa

gctg

cacc

attc

caac

tgcc

1803

2517907

—NO

taca

caaa

ttgaa

cgcg

gtag

ggtg

gggg

agga

agta

ggga

gata

aagc

ctat

gctg

ctga

ttcct

caat

tata

ggag

cagt

ctct

aaaa

gccc

tcgt

caat

ctag

tgat

gtgt

1804

3156168

NO

gtgc

aagc

tgtg

tagt

ggat

cattg

agtg

t1805

3359979

NUP98

YES

ggac

tcttt

ggaa

ccac

aaat

acca

cctc

taat

ccttt

tggc

agca

catc

tggc

tccc

tcttt

gggc

caag

tagt

tttac

agct

gctc

ctac

tggg

acta

ctat

ta1806

3701355

—NO

tcaa

taaa

agttg

tattg

agat

gtga

ttcac

atac

tgta

caat

ttatc

ccttt

aaaa

tatg

caat

tcgg

tagt

tttta

gtgc

attc

acag

agttg

tgca

gcca

ttatc

gtaa

tcag

tt

1807

2329396

HMGB4

YES

gtca

gcta

gaaa

ccgg

tgca

gagg

gaaa

ag1808

3290788

CCDC6

NO

tcca

tgct

caag

agcc

attg

taag

agat

taag

gggt

ttcta

ggttt

ttggt

gattt

tttgt

ttgttt

ttttc

tttgt

ttttta

gggt

tttttt

ttcttc

tttaa

tttttt

gatta

aaa

cata

caca

cagc

tgtta

gcat

aaag

tcgt

gggg

ggca

ttttc

tgga

atgc

tcag

cagt

tctg

atta

actg

ccaa

gccc

aggt

tgcc

tctc

atga

ggca

actg

aaa

aaat

cctg

tgtc

ttgat

agca

tggg

tgc

1809

3449856

—NO

ctttg

actc

cattg

tctg

ctttg

gct

1810

3573894

DIO2

YES

aggg

gaac

caga

gcgc

acaa

ggga

a1811

3670649

—NO

ccac

gttg

tcaa

gcac

agaa

ctat

aaaa

acaa

tgga

ttcag

tggg

tgaa

ggta

ggag

aagg

ggttc

aaga

gattc

agac

ttaca

gtag

gaaa

gtta

tttttc

caa

tctc

agta

agttt

tttag

ggtta

tgaa

gattg

agca

ctga

cgac

gctg

aaat

acca

cagt

gcaa

atgc

ttccg

taga

ttccc

tggg

ctct

gcac

tcac

caga

tcc

atttc

tatg

ataa

agca

caga

gctc

ctca

aaca

gaac

agtc

gagt

tgca

ggct

cagc

agcc

tcct

tgtc

agtg

tcct

gctc

aact

cagc

1812

3851066

NO

tgca

gtgc

ctgg

atca

taac

tctg

gatc

atca

ctga

aacc

t1813

3912092

SYCP2

YES

tcct

tggg

agac

ctgg

caaa

atga

at1814

2626159

RPP

14

NO

tcta

ctttt

aaat

cagg

cgtg

gcag

c1815

3448099

BHLHE

NO

cacc

agct

gtaa

aaga

tcct

atgc

gaaa

gaca

ctgg

ctct

tttttt

taat

cccc

caaa

taaa

ttttg

cccc

ctttt

aggc

catg

ttcca

ttatc

tctta

aaat

tgga

a41

ccta

attc

gaga

ggaa

gtaa

gaag

ggtc

tgttc

tgtg

gctg

agct

aggt

gaac

cccg

gggt

aggg

gaaa

gatg

ttaac

acct

ttgac

gtct

ttgga

gttg

acat

ggaa

cagc

aggt

agttg

ttatg

taga

gcta

gttc

tcaa

agct

gccc

tgcc

tgttt

tagg

aggc

gttc

caca

aaca

gattg

aggc

tcttt

taga

attg

aattt

actc

ttcag

tattt

tcta

atgt

tcag

ctttc

taaa

aggc

atat

atttt

tcaa

agaa

gtga

ggat

gcag

tttct

cacg

ttgca

acct

attc

tgaa

gtgg

tttaa

atgg

tatc

tct

tagt

aact

tgca

ctcg

ttaaa

gaaa

cacg

gagc

tggg

ccat

cgtc

agaa

ctaa

gtca

ggga

agga

gatg

gatg

agaa

ggcc

agaa

tcat

tcct

agta

cattt

gcta

acac

tttat

tgag

aaat

tgac

catg

aatta

atgg

actc

atct

taat

ttcttc

taag

tcca

tata

taga

taga

tatc

tatc

tgta

caga

tttct

attta

tcca

tag

atag

gtat

ctat

acat

acac

atct

caag

tgca

tcta

ttccc

actc

tcat

taat

ccat

catg

ttcct

aaat

ttttg

taat

ctta

ctgt

aaaa

aaaa

gtgc

actg

aact

tca

aaac

aaaa

caaa

aaac

aaca

acaa

caaa

aaac

aagt

ccaa

actg

atat

atcc

tata

ttctg

ttaaa

attc

aaaa

gtga

acga

aagc

attta

actg

gcca

gtttt

gattg

caaa

tgct

gtaa

agat

atag

aatg

aagt

cctg

tgag

gcct

tcct

atct

ccaa

gtct

atgt

atttt

ctgg

agac

caaa

ccag

atac

caga

taat

caca

aag

aaag

ctttt

ttaat

aagg

ctta

aacc

aaga

ccttg

tcta

gata

ttttta

gtttg

ttgcc

aagg

tag

1816

3872

452

ZN

F552

YE

Sag

cacg

agag

actg

ctcc

ctac

agaa

gaac

cttc

tgtg

tggt

gtga

atgt

ggga

aatc

ctct

agca

aata

tgac

agct

tcag

taat

catc

aagg

agttc

acac

taga

gaaa

aacc

ttata

cgtg

tggg

atat

gtgg

gaaa

ttattt

aaca

gtaa

gtcc

cacc

tcct

tgta

cacc

agag

aattc

acac

tgga

gaga

agcc

atat

gagt

gtga

ggttt

gtca

gaaa

tttttt

aggc

acaa

gtac

cacc

tcat

tgca

cacc

agag

agttc

acac

tgga

gaaa

ggcc

atat

gaat

gcag

tgat

tgtg

ggaa

gtc

attta

ccca

cagc

tcta

cattc

cgtg

ttcat

aaga

gagt

tcac

actg

gtca

gaag

cctta

tgag

tgca

gtga

atgt

ggga

aatc

ttttg

ccga

aagc

tcca

gtct

cact

aaac

acag

gaga

gttc

acac

tgga

gaaa

agcc

ttacg

ggtg

cagt

gaat

gtga

aaaa

aaat

ttagg

caaa

tctc

ttcac

ttcgt

catc

1817

2489

627

POL

E4

NO

gtgt

tctg

cata

agtg

gcttc

ctga

1818

2934

111

—N

Otc

aaga

ttata

tatg

gcag

atga

ggat

aa18

1931

8129

0T

MO

Dl

NO

gtaa

tggc

ccag

ctta

gaga

cttc

agct

actg

atct

catc

actta

ttaga

caaa

ttgct

gctg

acct

tacg

cctg

tata

ttaag

cctc

cgca

ggat

gccg

gaca

atg

gtga

agaa

actc

caga

tatc

aagg

aattg

ggaa

atcc

tggc

caaa

ccac

ccca

agat

gatta

cact

gaaa

tgta

gtat

tagt

actg

ctgc

caga

tctc

ttttt

aaca

tcat

gtgc

gtct

cttg

ggat

ccag

caaa

agtg

ttaag

ccac

aatg

ccct

tgtg

ccttt

taat

atac

caca

gtgc

cagt

taaa

ctaa

tattt

ttgttt

gttg

cttt

tggg

agtta

ttttc

atta

gtga

tttca

gcaa

atct

catg

ataa

agga

caag

gtca

agaa

ctcc

agag

cact

gagc

agag

aggc

tggt

gatg

aaaa

ggtg

aag

gcct

gcgc

actg

aact

gtaa

1820

3487

237

AK

APl

YE

Saa

tgttc

cctg

tgcc

aagt

tcac

aagt

g1

1821

4009

127

JAR

IDl

YE

Stg

agtg

tccc

ccca

cagt

agtg

gtga

agga

ggag

ttagg

tggg

gatg

tgaa

ggtg

gagt

caac

atcg

ccta

agac

cttc

ctgg

agag

caag

gagg

agct

Cga

gtca

cagc

ccag

aacc

ctgc

acca

agat

gacc

atga

ggct

acgg

a

1822

2750

647

—N

Otg

agta

cagc

ccac

tgat

tgac

attc

aaga

ccca

ttgga

aaaa

tcag

gaga

caca

agag

tggg

aaga

gtgc

agat

tgga

gcag

ctat

ccaa

aaat

aca

1823

2916

198

ZN

F292

YE

Sgg

gctg

gact

tgct

acct

gtat

agaa

ctgt

gtgt

aaag

gctc

ttcgc

ttgga

gtct

acag

aaaa

tact

gaag

tgaa

aata

tcta

tttgc

aaga

ccat

ttcat

gttt

gttg

cctg

atga

tctg

gaag

ttaaa

cgtg

cttg

tcaa

ctga

gtga

atttc

ttattg

agcc

taca

gtag

atgc

gtat

tatg

ctgt

ggaa

atgt

tgta

taat

cagc

cag

acca

gaaa

tatg

atga

agag

aatc

ttcca

atac

caaa

ttcttt

acgc

tgtg

agct

gtta

cttg

tattg

aaaa

ctca

atgg

ccct

ttgat

ccag

aattc

tggg

attg

gaaa

acct

tgaa

acga

caat

gtct

tgca

ttaat

ggga

gaag

aagc

atcc

attg

tgtc

ttcaa

taga

tgaa

ctaa

atga

cagt

gaag

tata

tgaa

aaag

tggt

aga

ctac

caag

aaga

gagt

aaag

aaac

ttcta

tgaa

tggg

ctttc

tggt

ggag

ttggt

gcta

attc

tggc

cttc

ttaaa

gaca

ttggt

gatg

aaaa

gcag

aaga

agag

agag

ataa

aaca

gtta

agag

agag

ggga

tttat

atct

gctc

ggttt

agga

attg

gcaa

gcct

acat

gcag

tattg

tgtg

ttgtg

tgac

aaag

aattc

ctt

ggtc

acag

aata

gtac

gaca

tgct

caga

aaca

ttaca

aaga

tgga

attta

tagt

tgcc

ccat

atgt

gcaa

agaa

cttta

attc

taaa

gaaa

ctttt

gtcc

ctca

tgtc

acac

tgca

tgtta

aaca

atct

agta

aaga

gaga

ctag

cagc

tatg

aaac

catta

agaa

gattg

ggaa

ggcc

tcca

aaga

tcac

aact

acca

atga

aaat

cag

aaga

ctaa

tact

gtgg

ctaa

acag

gagc

agcg

acct

ataa

aaaa

gaat

agtc

tcta

ttcaa

caga

tttta

tagt

gttta

atga

caat

gatg

gttc

agat

gatg

agaa

tgat

gaca

aaga

taaa

tcct

atga

gcca

gaag

tgat

tcca

gtcc

agaa

acca

gtac

ctgt

taat

gaat

ttaat

tgcc

c

1824

2984

592

SFT

2D1

YE

Stg

gcttc

cggg

cggc

ataa

agct

ttttg

cagt

gtttt

atac

cctc

ggca

atct

tgct

gcgt

tagc

cag

1825

3123

564

—N

Oca

gttc

attc

cgttt

ccac

ctgg

cagc

tgct

ccct

ctga

cacc

caag

gact

cgca

ggga

gtgg

ccgt

tgga

cctg

caga

cc18

2631

6587

9T

EK

NO

gtag

cagc

cagt

cccg

tttca

tttag

tcat

gtga

ccac

tctg

tcttg

tgttt

ccac

agcc

tgca

agtc

agtc

cagg

atgc

taac

atct

aaaa

atag

actta

aatc

tca

ttgct

taca

agcc

taag

aatc

tttag

agaa

gtat

acat

aagt

ttagg

ataa

aata

atgg

gattt

tcttt

tcttt

tctc

tggt

aata

ttgac

ttgta

tattt

taag

aaat

aaca

gaaa

gcct

gggt

gaca

tttgg

gaga

catg

tgac

attta

tata

ttgaa

ttaat

atcc

ctac

atgt

attg

caca

ttgta

aaaa

gtttt

agttt

tgat

gagt

tgtg

agt

ttacc

ttgta

tact

gtag

gcac

acttt

gcac

tgat

atat

catg

1827

3887

555

...N

Otc

cattc

cagg

attg

gtgc

tgaa

gcac

atgt

gtcc

tgaa

gttc

agga

cgtc

aggg

taat

tgac

acag

aaga

aa18

2823

5674

0—

NO

tata

atct

agaa

acat

tcttc

agcg

tttttt

ttcttt

catta

catg

aaga

gtca

agac

cagt

ggttt

tgtg

gaat

gcat

gata

atct

gggt

tctta

aaaa

tcat

ttcttc

ttga

ttaga

tttcc

cattg

tcttg

aattg

actc

agtc

agcc

tttcc

tcac

cgct

actc

cagg

ttcac

taat

g

1829

2665

536

C3o

rf48

YE

Sga

gaat

ggat

aggc

tttta

ggtc

ttgga

agaa

aaga

agtg

tcca

gggt

tcaa

tgga

gtgg

ctgc

tct

1830

2833

553

._-

NO

ttttg

ggga

tgac

attg

tgga

aagt

ttacc

ctca

1831

3242

698

-_-

NO

tgta

atac

ctca

tcat

agat

atttg

gggt

gccc

ttca

1832

3911

222

PME

PAN

Oga

agttc

tagc

cact

cgag

ctca

tgca

tgtg

aaac

gtgt

gcttt

acga

aggt

ggca

gctg

acag

acgt

gggc

tctg

catg

ccgc

cagc

ctag

taga

aagt

tc1

tcgt

tcat

tggc

aaca

gcag

aacc

tgcc

tctc

cgtg

aagt

cgtc

agcc

taaa

atttg

tttct

ctct

tgaa

gagg

attc

tttga

aaag

gtcc

tgca

gaga

aatc

agta

cagg

ttatc

ccga

aagg

ta

1833

2676501

—NO

attg

aaga

accg

ctgc

tgga

gaac

t1834

2839345

___

NO

gcag

cctta

ttcag

caac

gctg

ggga

tgac

aaca

tg1835

3239038

___

NO

gaat

aagc

agaa

acgg

ctgg

gcgt

g1836

3475695

ZCCHC

YES

cctc

ggaa

tgct

gctc

gaat

aagt

gaaa

agag

aaaa

gagt

atat

ggat

gcct

gtgg

agaa

gcaa

acaa

tcag

aattt

ccag

cagc

gata

ccac

gcag

aag

Q Oaa

gta

1837

3563672

NO

gttc

tgag

gccc

agca

actc

tgag

a1838

2333149

CDC20

YES

acct

gaac

cttg

tgga

ttgga

gttc

tggg

aatg

tact

ggcc

gtgg

cact

ggac

aaca

gtgt

gtac

ctgt

ggag

tgca

agct

ctgg

tgac

atcc

tgca

gcttt

tgc

aaat

ggag

cagc

ctgg

ggaa

tata

tatc

ctct

gtgg

cctg

1839

3740914

NO

ctgg

tgag

gagc

cgca

actg

ggca

tctc

c1840

3949524

___

NO

ataa

aaca

tcttt

gacg

tggg

agct

gcag

tact

g1841

2598329

FNl

YES

cattg

tctc

cacc

aaca

aact

tgca

tctg

gag

1842

2354732

___

NO

gggt

gtca

tgga

atct

tagg

agcc

ctgc

attc

caat

tgcc

cagg

ctt

1843

2534399

—NO

caga

atga

tgga

gtttg

catg

gcac

agt

1844

2677654

C3orf63

NO

cagt

acct

gcgc

aatc

cttg

attta

atga

aatta

aattt

tttat

ttcaa

aaga

tagg

cttc

tgttt

atca

aagg

cgttg

aaca

atttg

atttt

taaa

ttagt

tttag

caaa

o OO

atgg

aagt

ataa

tggg

aata

tattt

ttgag

gtgg

tctta

gtag

taat

tacc

atttg

ttgaa

caca

ttaat

gcta

tact

agac

agat

acag

tgga

gata

gcttt

caaa

cccg

tatc

tattc

ctaa

ctac

tgcc

tcta

atac

taat

tact

aact

tgtta

ctaa

tgct

aact

tttaa

aaat

gtttt

tgaa

aattg

caat

ttcta

caaa

taaa

tgtc

atag

tgca

aata

aatg

tcag

gattt

agag

aagg

agcc

taaa

ctga

atttg

tgtta

tttca

gtaa

aagt

tatg

gagt

tatg

ggtc

taga

cgtg

ttaat

aagt

taga

caga

act

ttggc

acttt

agaa

caaa

tgca

tgag

tggt

atttc

agttc

ctaa

gtta

cata

aaaa

gtgt

gaaa

gaac

actg

tgag

gtcc

cagc

aacg

ccag

acta

tatta

agg

taag

taga

aagt

gtttt

tata

gggc

ttcaa

tacc

cagg

tggt

gaca

gagc

agaa

gaac

cggt

tttttt

tttttt

tttttt

acta

ctaa

gcttt

taca

aaag

aagt

atct

gttt

tattg

tata

gaac

aagt

acag

cattt

tact

acat

agta

taca

agttt

ttaat

gagc

attta

aaaa

aata

agta

aatc

tagg

ctat

ttgaa

aaat

acag

ttgag

cca

gtga

gcac

atttt

ataa

tttgg

aaga

caca

aatc

aaat

gtga

agga

tttga

ttttc

taca

tttaa

aatg

aaga

acca

aaac

tctc

ttcttg

atttt

cagc

taaa

ggca

ggag

acta

ctttc

caac

tcct

tttgc

ttctg

gaga

aggc

cctg

aaat

caca

ttgat

atat

gtttg

ttagt

aaaa

tgtg

caca

cctg

acttg

caat

gttg

tgtta

aact

agaa

ttata

ttcac

ttgga

aaac

atat

cgct

tagg

ataa

aattt

tgtc

a

1845

2495347

—NO

agaa

agtc

ttaat

ggga

gagt

gccc

atgg

tata

t1846

3436411

—NO

cacc

atcc

ttgag

gggt

cgag

ccag

gact

ggaa

cctc

agtc

cggc

cact

acaa

cttc

ataa

atac

catc

gccc

tgag

atgc

tgaa

atcc

cagg

ggcc

ccc

cacc

ctca

gacc

aggt

gccg

gtat

tg

1847

3630941

—NO

tccc

tggt

atgt

acac

gcat

tcct

gtgt

tttgt

gaaa

aacc

gaca

ccat

gctc

ctcc

ctca

ctac

atgt

aaaa

cact

tttat

tcat

taaa

aaga

aaac

tgac

tggc

ttg

gacc

taca

aatta

gtttc

atta

tttgt

taat

gtttg

aaag

ccat

taaa

agat

gaat

atta

aggt

ttcttt

atac

tcaa

tact

tgta

gtttt

gtttg

gggg

aatg

agag

gatg

ccct

tggt

acct

ttgtg

aggc

ctct

ccac

tgag

ggtc

aatc

atga

cttc

tgttt

taaa

ccag

ccca

tccc

atct

tctc

cagc

tgct

ctcc

ttatg

tcttg

cttc

tct

cccc

tcca

acct

tctc

agca

taag

gact

caat

ccta

ggct

ccta

cccc

agac

gggt

gcct

tcca

acgt

tcct

ggtg

c

1848

3886257

—NO

cact

tggg

ttgga

aact

ctgg

cttc

tttcc

cccc

atgg

cctg

tttgg

ctca

cagg

tgcc

acca

gcct

cacc

ttgat

ccac

tgtc

acttg

tgct

tact

cggt

gtta

gct

gcttt

gcct

ccttt

cagt

ccct

cgaa

ccct

gagc

tcttc

tcag

agct

ccta

gtgc

tcct

ctgt

cggc

ctgc

agtg

cact

cccg

cttg

tgcc

tattg

tgta

1849

4004292

—NO

agga

tgaa

ttctc

acca

acca

tata

ttattt

tccg

ataa

cagt

gtttg

gtag

tgag

gggg

atct

attg

ctag

gtaa

aata

cgat

ggat

tcaa

ggag

ctta

ctgt

ttgat

gata

gggc

aaga

tgtg

ttcat

ggat

acta

gattg

aga

1850

2960481

—NO

ttgga

gcca

gtca

ggct

tttgt

ttaga

cattt

taac

tttttc

ttgct

ttcct

tgca

aact

cctc

agcc

ttcag

actg

gttg

gaaa

gtaa

atgt

acaa

tctta

cata

aattt

tcag

gtaa

tagc

atttc

agct

ttttc

ccca

agat

tttttg

cttg

ggag

gaga

caga

ttaga

ctgg

attc

ggag

tcttg

atttt

gcaa

aggt

aaca

aaag

acat

gttt

tttta

taag

acttt

tcat

cata

agttt

atttt

attc

aaca

gaag

caaa

atct

aata

taat

ggaa

aaaa

taaa

gatc

tgtg

ataa

atct

gatc

tgtg

tgga

taaa

caca

atta

gaaa

gact

taaa

gatta

agta

ttgaa

acaa

acta

ccaa

aata

tttta

atac

tgat

ttgta

aaaa

tttca

gtac

atttt

tcttc

tttgc

ttaat

tcta

ctgg

gtcc

tgtt

t1851

2977359

—NO

tagt

cattg

gtga

agca

ggat

tcca

a1852

3199214

—NO

tcag

gcttc

tgttg

caag

ccaa

tgta

ggga

acca

1853

2743060

—NO

ttcct

gagt

tcaa

gata

tagt

taag

tttaa

ataa

tagg

acttg

tgta

tgaa

ttgga

tggt

gtgg

gagg

gaaa

tcaa

aagt

tctg

ggcc

gggc

gcag

tggc

tcac

gcct

gtaa

tccc

agca

ctttg

ggag

tctg

aggc

gggc

agat

caca

aggt

cagg

agat

tgag

acca

tcct

ggct

aaca

cgct

gaaa

cccc

atct

ctac

taaa

gata

caac

aaaa

tccg

ggcg

tgg

O1854

2811122

NO

agga

gttc

tcca

cata

ctct

gccc

accc

tgat

agca

actg

aggt

aggc

caga

aact

tctc

atgc

actg

gtta

cctc

ctga

gcca

tcca

caga

aagg

gtca

O1855

3560070

—NO

gtgt

gatc

aaaa

aagt

ggtc

agtg

tgaa

1856

2597541

—NO

acat

tgaa

attc

aaga

tgca

ggca

gaga

aaga

ggac

atag

acca

gat

1857

3747622

___

NO

gcgc

gtgc

tcaa

cttg

gatg

ggac

acac

ctag

tcttt

cttc

aagt

ccct

ggat

tcaa

agag

cttc

aacc

gttc

ttgca

ccgt

cagg

c1858

2332216

—NO

ttgat

tcat

ccta

tccg

tgag

cgtg

g1859

3029849

—NO

gctg

gcac

ccca

gaag

aagc

tagc

tcag

catg

tgcg

ggtc

1860

3090304

ADAM

YES

atac

attg

atct

ctat

ttggt

gctg

gaDECl

1861

3441298

___

NO

acta

tctg

aaaa

tggg

cagg

tggt

gca

1862

3584491

NO

tgcg

atct

ccgc

tcaa

aaag

atac

ttttg

aatc

ctttt

caaa

agta

atttg

tgttt

cattt

tttaa

ttagt

atga

taag

cact

tcaa

gacc

cttta

caat

tctg

gcta

gat

ttggt

tgcc

atat

ttaat

agca

tttta

taaa

taat

ggag

aaaa

ggga

aaca

ttatg

catg

cttg

atta

cggt

catg

agct

gcat

taac

aattc

cgttc

aaca

acag

act

gcat

atgt

caga

gcag

tccc

ttaag

atta

caaa

1863

2775809

SEC31A

YES

gtaa

acttt

gagg

atga

ttctc

gtgg

aaaa

tacc

ttgaa

cttc

tagg

atac

a1864

3380586

SHANK

YES

tttcg

atac

aaga

agcg

ggtg

tata

aaca

agcc

agtc

tcga

tgag

aaac

agttg

gcca

agct

ccac

acga

ag2

1865

3410510

NO

tgtg

tccc

gcag

ctca

atca

gact

tctg

gatg

ccat

caag

gagg

tctg

catg

acct

aagg

atca

ttgttc

tttga

aagg

aaaa

caag

ttcat

taat

ctta

ctgg

ctg

ccag

ggtta

ggat

gcaa

agtta

atca

atta

ttagt

gact

accg

tcta

ccga

atga

ctac

gtgc

aagc

agtc

atgc

atgg

agga

agaa

aagg

acaa

agag

aaag

gaaa

ataa

gtaa

aaaa

caaa

cgttt

aatg

atttt

gata

atat

aggc

tcag

ttaca

tcac

caca

aaca

1866

3266758

NO

gttc

tgga

actc

ttcac

acct

gtga

cctg

cat

1867

3878506

SEC23B

YES

gaaa

ctgg

agca

ccca

tcct

aact

gatg

atgt

1868

3189392

—NO

tgca

agat

tcttg

gatc

ctcg

tccg

gtac

atttt

ggct

gcat

tttat

gtga

cgttt

gtga

gggg

gtta

gaaa

tact

ttaaa

atttc

aggg

aact

tgaa

taac

aatg

aaa

gatg

tgca

gcta

gtcc

aaac

agat

ggac

ttcag

tagc

aattc

cagg

ggcg

tttc

1869

3737624

KIAA

13

YES

ctcc

ctgc

agaa

gcgt

cccg

acgg

ccac

atcg

tgag

tgtg

ag03

1870

2587558

SP3

NO

tagc

cgct

ctcg

aaaa

ccta

cgct

gcca

cggc

cgct

cattg

tctc

tccc

cttc

cacc

cggg

ggca

aaca

ggaa

gcgc

gccg

cctg

gcag

accg

acgg

acag

gcgc

ctgg

acca

atga

gcac

agcc

gaca

aaga

gcac

ggcg

gcga

atga

1871

2636399

BOC

YES

gccc

tacg

tggt

gtcg

ggct

acag

cggt

cgcg

tgta

cgag

aggc

ccgt

ggca

ggtc

ctta

tatc

acct

tcac

ggat

gcgg

tcaa

tgag

acca

ccat

catg

ctc

aagt

gg1872

3383004

RSFl

YES

aact

gcca

gtca

tagt

gaag

ctag

aaaa

acct

ttgcc

agaa

aatg

aaga

aaaa

aaga

ttatc

aaag

aaga

aagt

gattc

cttc

aagg

aaaa

tgtc

aaac

cca

Otta

aagt

tgag

gtga

agga

atgt

agag

caga

tcct

aaag

atac

caaa

agta

gcat

ggag

aagc

cagt

ggca

cagg

agcc

tgaa

agga

tcga

atttg

gtgg

Oca

atat

taaa

tcttc

tcac

gaaa

ttact

gaga

aatc

tact

gaag

aaac

tgag

aaac

ttaaa

aatg

acca

gcag

gcca

agat

acca

ctaa

aaaa

acga

gaaa

ttaa

actg

agtg

atga

ttttg

acag

tcca

gtca

aggg

acct

ttgtg

taaa

tcag

ttact

ccaa

caaa

agag

tttttg

aaag

atga

aata

aaac

aaga

ggaa

gaga

cttg

taaa

agga

tctc

taca

atca

ctgc

tttgg

gtca

tgaa

ggga

aa

1873

3959450

—NO

tgttt

ttatc

acag

ggcc

gtcg

ttgaa

gcat

gtat

gact

atgt

gtgt

gaaa

atgt

tctg

caaa

ccaa

aaag

ggct

cagg

tgct

ataa

tt1874

3984482

SRPX2

YES

gatg

agat

gcca

cgca

ctac

cattc

atca

ctag

tggc

actta

cacc

tgca

caaa

tgga

gtgc

ttcttg

actc

tcgc

tgtg

acta

1875

2333884

___

NO

ttgta

gagt

atga

acac

tcct

ttact

ttcag

caac

gtcg

gcat

ctcc

aaat

aa1876

3392870

—NO

atgc

atga

gggc

acgc

ctcc

tact

ttc1877

2395894

CLSTN

NO

gccg

cgcg

gtttc

ccttc

gcag

atgt

gtat

1

1878

2701311

NO

attg

agcc

tgcc

catc

atgc

attg

caac

agga

aggt

ggat

ttgaa

aagg

gaaa

agaa

ttaaa

acat

ccca

tcac

acgt

gtaa

t1879

2976681

—NO

caga

tacg

ggtg

tgta

cttg

aatc

aagg

agag

gcag

taga

gcag

cctta

tgttt

tgttc

ccca

aaga

gtga

gatg

tgta

ccca

attc

ttgca

cata

gtga

aga

agct

gttc

tcttt

tttgt

tgttt

gtca

catc

tgat

tattc

atgg

agaa

agttg

cagc

ttggg

gcta

gtaa

aattt

tttttt

aaca

ccgt

tctc

atat

tattt

gctc

tcttc

tttt

aata

aagg

acag

atag

gcct

tgat

gtgg

ctgt

aa

1880

3398768

NO

gcaa

ctttc

agtg

gagg

cgct

gaga

gcaa

attg

cagc

agag

atgc

gctc

aggg

tgca

gtaa

caag

gaag

gacc

cgct

ctcc

gtgt

cagt

ggcc

tgca

gggg

aagt

gaga

accg

ggct

catg

ctgg

gctc

ctct

acttt

gcag

ggttt

aagg

ccg

1881

2376

766

SRG

AP

YYEE

SSac

taca

gcat

gaag

gaat

tttcc

gggt

gtca

ggat

ccca

218

8226

4835

1...

NO

ggag

cagc

ttcaa

tcaa

aagg

cggg

gctt

1883

2855

376

FLJ3

225

NO

ccttt

tctg

gggg

atcc

tagg

caga

agcg

atgg

cagg

acaa

518

8437

1558

5...

NO

aatc

acca

tgac

aggc

agag

tgtg

ggca

1885

2432

021

...N

Oag

tttag

ttctc

ttacg

tgtg

gcta

gcca

at

1886

2527

209

RPL

37A

NO

ttttta

taat

gtgt

ctag

gctg

ggt

1887

3753

258

—N

Ottg

agct

gccc

aagc

cacc

taga

gg

1888

2607

727

...N

Ogc

tgtg

cgaa

tgga

ctca

gctg

cccg

aact

caca

gaat

atca

gtaa

cagc

accg

aaac

ttcac

a

1889

2970

557

HD

AC

2Y

ES

gctg

tcaa

ttttc

caat

gaga

gatg

gtat

agat

gatg

agtc

atat

gggc

agat

attta

agcc

t

1890

3233

715

LO

C39

9N

Occ

ttctg

caaa

tggg

gatg

agtc

ctc

715

1891

2555

212

PUSl

OYYE

ESS

catg

ctgc

atgg

ttgct

ggta

aaac

a

1892

2601

671

DO

CK

lYYE

ESS

tatc

ctgg

tgga

gcag

ctat

acat

gtgt

gtgg

agttt

ctct

ggaa

gtct

gagc

gata

tgaa

ctca

ttgct

gatg

tcaa

caag

ccca

tcat

tgct

gtct

ttgag

OU

1893

3630

677

CA

LM

LN

Otg

ggcc

tgaa

aact

tgga

gcaa

ttaat

tttttt

taaa

aagt

gttc

ttttc

acttg

ggag

agat

ggca

aaca

cagt

ggca

agac

aaca

ttacc

caac

tata

gaag

a4

gagg

ctaa

ctag

caac

aata

atag

atga

tttca

gcca

tggt

atga

gtag

atct

tta

1894

2677

724

AR

HG

EN

Ogg

cgcc

atca

gcca

ctttt

agaa

gcca

tcag

ccag

tgtg

ttggg

aaaa

gagg

tttgt

caag

tgttg

gcct

atgg

gaag

gtgg

tcaa

tgaa

tgttt

tga

F3

1895

2898

386

—N

Otg

gagg

cattt

aatg

gcga

tgtg

cagg

tgca

ag

1896

3412

766

AR

ID2

NO

catc

cacc

tcga

aagc

tggg

catta

acga

tattg

aagg

acag

cggg

tact

tcag

attg

cagt

gattt

tgag

aaat

ctttc

ctttg

agga

gggc

aatg

ttaag

ct

cttg

gcag

ctaa

tcgt

acct

gtc

1897

3975

856

NO

tgga

atgt

acct

ggaa

tagg

gaag

tgga

cagt

gagg

gc

1898

2466

297

...N

Occ

aggt

cgca

catc

agct

gcag

gcac

agcc

agttc

atgg

gtag

acag

ccac

atcc

tgcc

ccag

gagg

aggg

cagc

cagc

atgg

gcga

tgca

agct

cccc

tcgt

ctgg

aacc

agca

caac

ctca

ggca

ctcg

agcc

ttggc

ccct

caca

agca

acgt

cctc

aatg

ggtg

gcgt

tcgt

tcat

1899

3240

817

...N

Otc

catc

gattg

actg

cgag

gggc

tagg

gttc

acag

caag

caga

acgt

cctg

ggttt

ctct

tcaa

tacc

acct

cctc

ctct

cctg

ttcag

atgc

tgag

aaac

atc

tggc

gcag

taga

gatg

ctgc

ctct

gaca

tttct

atga

caaa

acgc

gtgc

ctgt

gcta

gggt

ttgca

cagg

caca

agtta

tcac

aacc

tcgg

gatg

gggc

tg

1900

3454

311

LA

SS5

YE

Sca

tcac

ttggt

cacc

attg

ggct

tatc

tcct

tctc

ctac

atca

acaa

tatg

gttc

gagt

ggga

actc

tgat

catg

tgtc

taca

1901

2437

092

DPM

3N

Ogg

gagt

gggt

ctca

aata

taga

gggg

gtag

caag

gtgg

aagg

ggcc

cttc

cacc

ttttg

tggg

cact

caag

ttcgg

acct

ctgg

gatc

ggcg

attc

cc

1902

2683

293

NO

catc

tgtg

cttg

acgc

agag

gcct

ccgg

ggtc

gcga

gcttc

ggag

gtgg

aggt

gccc

cgtc

ttcgg

gttc

ccac

gccg

ccct

ggcg

acct

gggg

ctcc

agc

ccca

ccgc

ggac

tccg

gtgg

gacg

tggg

tggc

gcaa

gcac

acct

tgcc

cctg

tgac

tcag

cttg

aggg

ggcc

caag

ctgt

ccca

ctga

gcac

gcgc

ccag

cagg

ccgt

cgcg

ctgc

gggt

cctg

gtcc

tcct

gtca

tttac

tggg

gtgc

ggag

gcct

ccga

ggag

tctg

aggg

tggg

acag

tccc

acttc

cgga

gga

gcta

gggc

aggg

aaca

caaa

gtcc

cgag

tgcc

gggg

ca

1903

3701415

—NO

ccat

aaaa

ttcgc

atgg

tgaa

atgc

acgt

aaca

taaa

attta

ccat

ctta

acca

tttaa

atgc

acag

ttcag

tggt

atca

gata

catta

ata

1904

2590322

—NO

ctag

aatta

agat

atgc

tgat

gagt

tgct

tctg

cagt

tcat

1905

2973489

—NO

tttgg

cgttt

gcta

caga

atgg

tgaa

tttat

gtat

ttctc

ttcca

ctttg

acat

ggac

attg

cctc

attc

ttcag

tagt

gtgc

atat

tcac

ctta

attta

ttcaa

aagc

tat

tttac

ctttt

tcaa

taac

acca

catc

aatta

cctta

actta

ttcac

ttaca

tcag

tcttc

cc

1906

3020769

NO

ggat

gcag

gact

gagt

catg

ccac

t1907

2807755

—NO

gagt

agat

gtaa

ctaa

gagg

tttga

gaaa

ggaa

tttca

gcag

agtta

ttgaa

ggag

aagt

caag

gaga

ggag

aagg

agag

gagc

agtg

aatg

ttgtc

gtg

aaga

ggtg

ttgtc

ttgaa

atac

tg

1908

2918704

PRDMl

YE<

ctct

ggag

tgga

tagg

gtta

atcc

gggc

agcc

agaa

actc

ccag

3

1909

3024096

___

NO

taac

aata

tgtg

cagg

cagg

accg

aaaa

O1910

3270274

—NO

gggc

gcttt

ccca

ctgt

tcta

gacg

tagg

agag

aaag

cact

tctc

agat

ggtg

agct

tttat

cttc

caat

cttg

tcaa

ccga

ggag

acct

ggaa

gttc

ccttt

caac

ctgg

aatg

tgag

ccct

gcttg

ctgg

gcac

gaga

taag

gacc

aagg

attg

accc

agga

caat

ttcag

agag

caca

gggg

tggc

atat

cctc

atgt

cagg

gcgt

ggag

ctaa

tattc

aga

1911

3356025

NO

atgg

ccca

gaat

gggt

tgtc

agtg

ctcc

ag1912

3913713

YTHDF

NO

ggac

cgttg

agct

cact

acca

cctg

gagt

ttgag

ttgaa

gcat

gaaa

atgg

tgcc

catg

cctg

acgc

tcca

gcgc

ctgg

atct

gcac

gtgc

ccttg

taga

gg1

atcc

ttacc

gtcc

taga

gagc

agac

gcttt

ctga

aaac

tact

tgct

ccaa

aaga

ccct

ctga

gtta

acgt

ttcag

ctgt

atca

ttaga

cttg

tattt

agag

cgtg

tcac

ttcct

ctga

actg

tta

1913

3506761

NO

tgta

gtgt

tgct

gtat

cttc

catc

gtac

agtg

gaat

ggca

tctta

caga

aggg

gtttc

ggtc

ctat

ggtta

gctta

atgt

tgaa

gtca

ggga

aagt

caaa

atca

ccat

tgga

actc

ccttc

aact

gtct

ataa

aata

cact

atgc

acag

tacc

ttggt

ttacg

tata

tttgc

ataa

atac

atac

tttgt

atag

tcac

atgt

tgta

tgac

aact

tac

tgag

ttgttc

gatg

aaca

actc

tatg

tgct

aata

ataa

ttttg

atgt

atta

aaat

ggga

aagc

atttg

ctta

actg

agtg

gaga

ggca

cagg

ttgct

gagt

caga

cgt

atct

cctg

ttgca

cacg

tacc

ttcag

gatg

g

1914

3888725

PTPNl

YES

gcag

atcg

acaa

gtcc

ggga

gctg

gg1915

3357756

NO

tctg

tcca

gagt

gcaa

ggcc

gaac

caga

ggac

acac

atga

tcat

ttcta

tttta

gaaa

cacg

cctg

gggc

agag

agga

cagc

aggt

gaaa

gaga

ctga

gag

agaa

cagt

caga

ggct

agta

ctgg

ccaa

gaca

ggag

agtg

aggg

agca

accg

taat

gagg

atgg

atga

ataa

tttga

gaga

gattt

aggg

gtaa

cga

acca

gact

cact

c

1916

2371244

NO

atga

gctc

acct

tgcc

tgca

actg

tctc

t

1917

2660674

NO

tgcc

cattt

ttcta

cggc

ttgttg

atttc

ttggg

agttc

cttg

taag

cttta

tagt

ctct

gtaa

ttaat

gagt

tcca

aaca

tttttc

ctag

tttgt

ctttt

gtct

tttgt

ttttg

gtg

tggt

gtgt

caaa

caga

actg

tttttt

tgttg

ttgttc

ttaca

tagt

ttaat

tttta

atgc

ttctg

tattc

taaa

tcat

agcc

aaaa

atga

cgttc

ccat

gcaa

agga

atgt

ctca

tgttt

tcttt

ggat

acttg

ctgt

ggttt

catta

ctttt

ccgt

ggaa

agct

ctga

tcct

tgtg

cagt

tgat

cctg

atat

aa

1918

3199144

NO

taga

atgt

ttgta

tattg

ctgc

ctgg

c1919

2411720

___

NO

agat

ccaa

ttaga

gcca

gggt

cagg

1920

2682075

—NO

tgat

aata

ggga

cgttg

tcag

accc

ttaac

taag

ccac

acac

tgct

ggga

gcct

ccgg

aata

acttt

aatg

tagt

tgta

ggga

aggg

agtc

gttg

gcag

gga

tgag

gatc

cctg

cttg

actg

ctct

ctttc

ctga

cgag

gaag

aaaa

ggac

agtg

atca

agca

cagg

gtct

caaa

ggag

gtct

ta

1921

2709855

NO

ggac

agca

ttacg

gtgg

acag

tgaa

1922

3016026

MUC3B

NO

ctgc

aaaa

cggg

taca

gcat

tcct

gtat

gata

gctc

acgc

cgtc

gttg

tgaa

aacc

acat

agac

ttggt

caat

tctc

ggtc

ctac

tctg

ccct

cccg

tctc

agc

III

cctc

gtgt

tgcc

attg

cMUC3A

1923

3550736

LOC730

NNOO

acca

ctac

ttcat

gcag

ggca

gtgt

gcc

217

1924

3059100

—NO

ggaa

gcta

ccaa

ggag

acta

ttaaa

gaaa

ttcag

gatg

gtga

agac

agct

taaa

ggga

aaca

gttc

tgca

aata

gagg

cgat

ggga

gata

tagg

aaag

a

Ogg

gact

atgt

gtag

gtct

tgttg

cgtc

gctg

aag

1925

3379723

MRPL2

YEJ

tggt

tggg

gcag

acaa

cttc

acgc

tgct

tggc

aagc

cact

1

1926

3432355

NO

cgtc

gtgg

atgg

atca

gtttt

gctc

gata

gagg

gaca

tgttt

ttctg

tggc

aaca

ggag

ggca

aaag

gaga

aggt

ggcc

acag

atgc

cggt

agat

gagc

tgag

agtg

attg

tattc

ccta

tcct

ctcg

gaag

cttg

aggc

aagg

ccat

caac

agac

aatc

agag

ggaa

taag

aaga

gata

gaat

atat

gaag

aaag

ggag

aaa

agat

gaaa

tcgt

aattg

tgta

gcag

ggca

agaa

gtcc

agaa

atttc

tgtg

ctgt

gcca

agttc

ccag

ttgag

gcgg

tga

1927

3511352

—NO

ctga

cggt

ttaag

atgc

tgca

tttta

agta

atgc

tgag

ttgta

ttttta

tttca

gtca

ttcat

ttcta

ctta

ttttg

agca

ccca

ttata

tgtta

ggttc

catg

ctag

gcac

tgta

aaga

taaa

gatg

agaa

agac

tcag

ccct

tacc

taaa

ggag

tata

gagc

ctag

ttggg

gaga

cagg

aggc

agat

agtta

cagc

atgg

agag

caaa

ttct

ctga

ggga

ggaa

tgaa

gtga

gata

agag

caca

gaag

aaag

accc

gggg

atca

gagc

agac

ttcct

ggag

gagg

caat

cattg

acttg

1928

2627501

—NO

tcct

gcttg

tgaa

caga

ttcct

atttc

cgtg

agga

ggtg

acct

cgaa

gaag

agca

gcttc

tattc

tgct

ggga

ggtg

tact

gcct

tctg

gtat

cagg

cttc

tgca

tccc

ggga

aagc

tcgg

gata

acct

gagg

cacc

1929

3608077

NO

agac

caca

atga

ggga

catg

gcaa

gttc

ct1930

2393810

___

NO

ttgag

gaaa

attg

ctct

gtcc

ctat

1931

2506539

___

NO

tcca

tttaa

atga

gagg

gtgg

agct

gtcc

ttgca

aacc

aatg

atgc

agct

gatg

ccat

gcag

tgga

tcttc

cttc

cccc

taaa

1932

3068053

—NO

tttcc

caga

gctc

tacc

ttgttg

tcag

cact

ccct

gcaa

tag

1933

3762439

NO

ctaa

gaga

gtta

ctga

ccct

aact

cccc

taaa

acct

aact

atca

aaag

ccta

ccac

tgac

tgga

agcc

ttaca

ataa

cact

aaca

gttg

g

1934

3896

232

—N

Otc

agtc

tgcg

atga

aggt

gaac

ccat

ctta

taaa

gcag

agct

tact

taca

ttctg

cagg

atttt

ggtg

tgga

tgca

taga

aggc

ttacc

tggt

tagt

aagc

ctcc

attc

ctcc

gacc

taca

gaag

gcaa

ccct

tctg

cagc

tcca

agca

ggga

tttct

agaa

aaga

ccag

gtgt

acaa

aaca

tcta

agct

gtgc

ctcc

cacc

acag

gtgg

ggaa

gtcc

cctg

atttg

gtca

gaca

caga

tgaa

tgtc

tgtg

tctg

actg

agcc

caga

aaca

gttc

aattg

atgg

gggc

tgga

acca

ccaa

gaaa

aca

ctcc

tgac

ctgg

gcaa

cact

gtct

tcca

gatta

t

1935

3916

144

C21

orf7

NO

tgtg

tgta

cctg

agat

aaga

tgat

gtct

tgtc

caat

gctg

gtttc

cacc

ttgtg

ccct

gagc

tgttg

ggag

aggc

tcct

gcga

cctg

tgac

419

3623

8957

8—

NO

ggct

tacg

cagc

agat

gcac

gttc

agca

ttgag

aacc

cggt

ccga

cagg

aaag

acac

acca

tttttc

cgcc

agaa

actc

cagt

gttc

aaaa

taca

aact

gcca

acttt

tcag

gcaa

taat

catg

agct

tcca

ttaga

aaaa

gcca

tcag

ctca

ccag

acga

cgaa

atat

gctc

tcgg

gatta

agaa

ctttc

tcat

cctc

cctg

agcc

ctttc

ctttc

aggg

gaag

tgca

agttt

g

1937

3290

995

AN

K3

YE

Sag

cggg

ctaa

cacc

actg

catg

tagc

tgca

catta

cgat

aatc

agaa

agtg

gccc

ttctg

ctttt

ggac

caag

gagc

ctca

cctc

acgc

agcc

gcaa

a19

3834

0315

3E

MG

lN

Otg

tcac

atcc

tttga

ccct

ggtc

tgag

ctga

ctgc

tgga

agat

gatc

tttct

gcac

tgag

actg

tgga

gtttg

ggga

agcc

aagg

ctgt

acat

ttgct

atttg

ttta

tcct

atga

atac

tgttc

ttgca

aacc

tggt

tgttt

tggg

gttc

ctaa

agta

tcca

gtgg

tgta

aaac

tgttt

gttc

cccg

ggac

ttcag

ggac

agat

agga

ggtta

caga

gtttg

cagt

ttggt

tcca

tgct

ttgaa

ggca

ggct

ttagc

tccc

agat

tccc

atgt

gcta

aagg

agag

aacc

ctga

tgat

ggag

aaga

actg

tgaa

aga

gagc

agtc

agga

atgc

tagt

ggtg

aaaa

actg

aaca

aaca

gaag

tgat

tttat

ctaa

taca

gttc

caag

gtag

aaaa

agtg

gagc

aggc

aggg

ccttg

cac

ccct

ctcc

accc

cccc

atgg

gggg

ggtg

gtgg

tagc

ggca

cata

caca

atc

O

1939

3439875

—NO

acct

ggct

ttggt

tattg

atga

gaag

agta

atta

atag

aaca

ttccc

tttgc

tgtg

atac

ccta

ccca

aaat

agct

cggt

tgttg

gttc

acttt

cttc

agat

acct

ccttg

tctc

atgg

accg

ccta

ctta

ct

1940

3568358

—NO

tcat

gggt

ttcca

aata

tggg

atgc

aattt

caag

ttctta

acac

caaa

tata

accc

tact

tgttt

tagt

ttcct

ggca

ttcat

ccta

tcat

cccc

agttt

actg

cacc

tcag

gtta

tcaa

ggat

gtgg

gagg

gattc

taca

aggg

tatg

ttccc

ccag

agct

ttttg

gtac

cctg

caat

ccca

gaag

ttgttg

atgc

tagg

atgt

ctgg

agag

cac

tggc

cattt

atta

ctga

1941

3701322

CDYL2

YES

tgac

gtga

atca

cgct

acac

tggc

ggag

aacg

ggct

c1942

2975832

—NO

gcca

tgat

cgta

gcac

tata

ctct

agcc

1943

3072788

—NO

gtct

aattc

agaa

cccg

gtgg

gctc

tcca

tgca

ttattg

gcag

cact

tttat

ccag

gggc

acag

acag

ggaa

tagg

gtta

ctgg

aaac

aggg

agtg

tagc

tcaa

ggaa

ttgttc

tctc

tctg

gagt

ggat

aagt

tgttt

gacc

tact

gact

cattt

cata

ggaa

ttagg

aaaa

caac

ctag

tgtg

gtttt

tattg

ttagt

cctg

gagg

attc

caaa

atct

gtgt

gcct

gcaa

ataa

gatg

agct

gggg

aaag

ggag

cacc

agca

tttgg

tgttt

ctac

ttgcc

tcttt

tcct

gatg

gaat

ccaa

tcct

ctgc

ttc

1944

3380

982

NO

gctg

tttca

gtcc

acac

cttg

ttcac

agta

agat

attc

aattc

aattc

agca

aaca

tttgt

tgag

tgct

tgct

gctc

tgtg

cctg

acca

gaag

aaat

gaag

ccaa

gat

acaa

ataa

taga

accc

tgtc

atga

gcac

agaa

agac

ctgc

tgag

tttct

attg

attg

tggt

aaac

cagc

ctgc

atcc

agttc

caag

taac

agct

gccc

actt

agtg

aata

ctct

ctca

tgttt

caac

actc

agttc

tagt

gtag

cctc

ttcta

taaa

gcct

ttcttt

tcca

gata

aaat

tggt

taat

gtgt

cctg

tgtta

ggct

gattg

tttt

gatg

atcc

ctat

tcat

ggtc

tccc

ctgt

atcc

atct

ctttt

tgcc

tata

acat

tgta

gtcc

catc

tcac

tctg

atgc

tggg

acca

gaca

tgtg

acttg

tttta

gcca

atga

gatg

tcga

taaa

catg

aagc

aaac

agaa

gcttt

aaag

gagg

cctg

ccct

cttg

ctct

ttgcc

agtg

ccat

gaga

acat

ggct

gatc

agct

ggag

ggtta

tga

gatg

tgta

ggtg

agag

acat

gcaa

aaga

gcca

gaga

tacc

agct

gaag

ccat

ccta

gact

agcc

caca

gtca

gcct

accc

ccag

tcaa

gatc

agga

gag

tcac

ccaa

ccca

caga

tgac

tgcc

gaca

catg

agta

agcc

1945

3902033

—NO

attc

cacg

cgtc

aaat

tgtg

ggca

gtga

1946

3952107

___

NO

acag

gcac

aggg

gagt

caag

ctta

g1947

2678585

___

NO

agca

ccca

gtct

ctgt

tctc

agag

g1948

3463862

PPFIA2

YES

tctc

ttggg

gatc

acga

gtgg

aata

gaac

tcaa

caga

ttgga

gtac

taag

cagc

cacc

ctttt

gaaa

gtga

cact

gaaa

tgtc

tgat

attg

atga

tgat

gaca

gag

aaac

aattt

ttagc

tcaa

tgga

tcttc

tctc

tcca

agtg

gtca

ttccg

atgc

ccag

acgc

ta

1949

3727958

...

NO

cacc

atct

tctc

ggat

ggat

ggca

aag

1950

3974043

...

NO

agca

agcc

agtg

cagt

ccttg

gtca

cagt

cact

caca

g

O1951

3982214

—NO

ccaa

aacc

aatg

tgtc

taag

gtgc

ggca

tcttg

1952

2685843

...

NO

gcgg

tggt

ccaa

tcat

agttc

acta

t1953

2686522

ABI3BP

NO

ccag

acat

gcca

ccaa

ctaa

atcc

g1954

4014220

POFlB

NO

cttc

ctct

gtag

ctgc

caga

cctg

c1955

2838069

TTCl

YES

aatg

gcca

tcaa

tgac

tgca

gcaa

ag1956

3701416

...

NO

cgca

tctg

gcct

atac

cagt

gtat

gtttt

cttta

ggaa

aaaa

taag

gcag

aaac

caga

aaac

taac

acttc

acat

aaat

gtag

gtgc

agaa

tattg

gtac

gata

ttg

gata

actta

aattg

ctga

actg

tatg

aaac

ttaat

ttttc

taag

gcaa

aaat

tgat

atca

ttgga

agga

tcttg

gagt

cagt

ggca

ggca

aaca

aaat

ttaaa

cttg

gctg

cattt

tcttt

tttcg

tttca

aatg

aata

ctta

acta

ggtg

caat

ggct

ttattt

gtgg

tcttc

1957

3756107

...

NO

tgaa

ttcac

agtg

ttgta

tccc

atgt

aggg

aaaa

ataa

gact

aattt

tccc

ccca

cact

ctaa

caca

ctgt

aattt

tgca

cttg

gaac

tttgc

taat

ctac

tgtc

caa

cctc

cttc

tcaa

caaa

gtca

aatc

aaag

gaga

atta

acct

agaa

gagg

ggac

aata

aaat

aaga

ggtc

ctca

ggga

gagg

gaga

acca

agga

aata

gaa

tcta

ctta

aatc

tggc

caga

tagc

acct

cgtg

gatt

1958

2382147

CAPN2

YES

atga

cagg

ctgc

ccac

caag

gacg

ggga

gctg

ctct

ttgtg

cattc

agcc

gaag

ggag

cgag

ttct

1959

2590022

ZNF385

NO

agag

aaac

acat

cact

agat

tgac

gagg

gcttt

taga

gact

gctc

ctat

aattg

agga

atca

gcag

cata

ggct

ttatc

tccc

tact

tcB

1960

3831701

...

NO

gtat

tggc

gact

gcct

gtgc

atac

ac1961

2792492

NO

ctga

ctgt

gaat

taga

gtttg

cgct

attg

gaag

gtgg

aacc

cact

gtgc

tcat

tgta

ta

1962

3289301

NO

gcat

ttact

agtg

ctgt

gtgc

ctcg

ttgct

tttct

gggt

agtg

tttgg

tgat

gggc

atag

tgtg

gagt

ggtg

gtag

agta

caca

gtgt

gattc

tgtc

tggt

aagg

aag

ctgt

atgt

tgat

gttc

actg

atgt

gaat

aggt

tcat

acag

tccc

ttagg

cattt

ggct

ggag

gata

aaga

acag

ccat

tgac

cagc

agag

tact

tttttt

gaag

tttat

gcaa

gaca

gcgt

gcta

ggta

ctac

tgcc

agct

tga

1963

3686344

XPO6

YES

gtcc

tttct

ccag

cccg

acat

ccac

ctttt

taaa

caaa

atct

cttc

tact

tgga

gact

ctca

acac

caag

caga

1964

2596800

—NO

tgac

taaa

atttt

gggt

ctgg

gctg

ttata

tcac

tttgt

gtta

agtta

tttgt

agta

gcta

atgt

gcta

actta

tata

tgtg

ttcttt

ctgt

tttttg

gattt

tacc

ttttg

tttt

ggca

taac

ttatc

tata

tttttg

tttac

atta

tttta

aaaa

tatc

agta

actg

taat

aata

taaa

attg

aagt

tgta

ttgttg

acaa

tacc

tcta

gtttt

taag

gtca

tctg

tca

cata

attta

agtg

cacc

agttc

ctaa

tgta

taaa

g

1965

2614940

NO

ctgc

tcca

ttgga

gact

tcct

gagg

gcaa

caga

caaa

ctat

ttgat

agct

gaat

1966

3988991

NDUFA

YES

tcat

tttgg

gtat

cact

ggag

tctg

atgg

aaag

agat

aggc

gcat

ctct

ggag

ttgat

cgtta

ctat

gtgt

caaa

g

1967

3068834

NO

tcat

ataa

taga

cagt

gcgg

ttgca

ccttg

tgttc

atgt

actg

atag

ctgt

taag

ggtg

cagt

gatg

aacc

aaca

gagc

tc1968

3116499

___

NO

gcct

ctct

gttc

tcat

gggc

taca

tg1969

3227229

FNBPl

YES

ccaa

cctg

aacg

aaat

gaat

gatta

cgca

gggc

agca

tgaa

gtta

tctc

cgag

aaca

tggc

atca

caga

tcat

tgtg

gact

tggc

acgc

tatg

ttcag

gaa

1970

3777767

—NO

tgtg

tttgg

ggtg

atta

gagc

ttcttg

caag

ctta

gaag

tagg

aagc

taat

g

O1971

3950135

___

NO

cact

ggca

cagg

acga

ccct

gaag

g1972

3425446

—NO

gcat

gtct

tgct

acta

cttc

atag

atgt

cata

agac

ccgt

ttatg

gatta

gagt

tggt

gtag

aaag

ccat

tgcc

ttgag

ttgaa

aaat

gaat

actg

taaa

agct

caat

acaa

atcc

tcca

aagc

acat

gcac

tt

1973

2359042

NO

ccaa

gttc

tcat

cttc

agca

tcgc

agttt

cgttc

tcca

cc1974

2437704

GON4L

NO

ttcca

ttcta

ttact

ctta

ggttt

gtat

ctca

tgga

attc

acttt

aacc

tctg

cctc

gtgt

tattt

gcttt

agct

gtac

atta

tgct

ctta

1975

2778373

___

NO

ccca

aaac

atag

atcc

gaac

acca

gcttt

gccc

1976

2954503

___

NO

atttc

ctac

actg

ttgat

ggtg

gcaa

tgac

aaaa

tcaa

ttgca

gtg

1977

2441001

___

NO

ctgg

agaa

atgg

ctat

gggt

gact

g1978

3162378

___

NO

gaat

tagt

tcct

cagc

ccag

tgta

agac

tgga

ttaaa

aatc

gtgc

atgg

atgt

gcag

gg1979

3199012

MPDZ

YES

cacc

cagt

cagt

caga

gtca

gagc

caga

gaag

gctc

cattg

tgca

g1980

3449682

___

NO

aagg

gtgt

ggca

cattg

ctgg

tgttt

tcag

ggaa

gaaa

gcag

aacg

tctg

tggg

caag

cagt

gg1981

3687337

NO

ggag

atcc

ttgtg

tagc

ggca

gaaa

gttta

gcaa

cact

gtct

cctg

catta

gtgt

ggag

ggta

ggaa

atat

acct

aagg

aacg

gatg

gtct

agct

aagg

agc

tttcc

agac

agaa

tgttg

aagg

tgcc

acct

ggct

tcttg

ctgc

ttata

gtaa

aact

gaag

agga

gaga

gtaa

gtta

aaga

aaaa

aaac

actta

aatg

aaaa

agag

cctg

aaat

tgttg

ggttt

gaaa

attc

ccag

ccttt

ccag

ataa

caag

tgat

gtta

aaat

taac

aaat

ggct

tccg

tgca

aaga

ttaaa

taca

aggc

atta

aata

cagg

gaaa

tgtg

gtct

aaag

gtca

agct

gagg

atgt

gatg

aaaa

agtc

ctttg

ttaag

acct

caga

aata

ccaa

caag

atgc

ctca

gagg

ggac

ttcca

gtc

gaat

gaaa

taat

aatc

acgc

ttctg

agaa

ggtta

aagg

tgttg

tcttt

cagc

gtct

cagc

acaa

gccc

aaag

taga

gaag

ggct

tacc

ttgca

gaga

ttttc

1982

2333554

ST3GA

YES

ccta

ccct

tggc

agtg

tggc

agtg

aL3

1983

2570354

NO

gtgt

tact

tcca

ccat

ggtg

ccac

acac

ttaat

atcc

attc

c1984

2873144

NO

gggg

cttc

tcta

tgcc

cgga

aact

gcct

catc

aact

gaaa

caaa

tcct

gaat

catc

aaag

ggcc

aaac

ccac

tgcc

acct

ttaga

cgga

gcag

gaga

gtta

ccct

ggct

ctgt

cact

gcca

ctaa

gtct

a

1985

3409485

NO

tgaa

tagg

cagc

tagt

acat

gaac

ctgg

catta

gggg

tttgg

ggct

ggca

tact

taaa

catg

tggc

taga

tgtg

atca

ccttc

agag

taaa

tgta

aata

gtat

cat

ccct

cctta

tctg

tatc

1986

3476542

NO

gtgt

gttc

cagg

cgat

ggca

ggag

gga

1987

3620299

NO

atga

cagt

ttttc

tcta

ggct

aata

actc

aatg

agca

gaaa

ggaa

agtc

ctcc

ctttt

aaat

gtat

atga

atgt

atat

gtag

ttcac

actta

cact

ctga

caca

gat

ctca

ttgtg

tcca

atga

tgtg

tgtg

tgtg

tgtg

tgtg

tgtg

tgtc

tcca

agac

tgag

acac

atgt

acta

aaga

gtga

tact

ggcc

acat

ctac

tctg

ggct

tgga

ggg

taac

ttcag

caa

1988

3626913

NO

tgca

acct

cgac

ctgc

ttggc

ttaag

caa

1989

2699759

NO

ccat

catg

agct

gacc

aaca

atttc

taaa

ttcct

actc

agaa

acac

agca

aggg

gaat

gcag

tcaa

gcac

aaag

ggct

taaa

tgac

caga

taag

gctg

ggc

tgga

tgaa

taaa

gagg

aata

tcct

atga

atgt

gact

gtgt

agttt

taga

gtat

cccg

attc

aact

gtta

tattt

gact

tgtg

gcct

tgta

gaca

gtgt

gtta

1990

2737582

NO

tagc

caag

tgca

gagg

gtgt

ctcc

gggt

gtgt

gcgt

ggcc

caca

agag

ggca

agaa

gaga

gaag

gcgg

ggat

agga

ggga

agag

ggtg

gggg

tga

gagg

cagc

cctg

agag

ggcg

gagg

aagg

aaga

ggct

ggga

gctc

ggcg

cccg

cggc

gcag

ctgc

cgtc

gctg

ccgc

agct

gtcc

aggg

agga

tcg

ccaa

aacg

gcga

cgaa

taaa

caac

ttacc

ttgcg

gaga

agag

ctac

gact

gcga

tgc

1991

2964449

MDNl

YES

cccg

atgg

aata

tgca

ggct

ctgg

acat

gatta

gaaa

tttga

tgga

ctttg

accc

acaa

acgg

acca

gcct

ga1992

3695220

DYNCl

YES

ggag

ctgc

cttg

attta

caca

tcag

LI2

1993

2939888

LYRM4

YES

taaa

gaat

atct

cctc

cagg

tgtg

gt1994

3632627

—NO

atgg

agat

ctac

actg

acac

cctc

agtc

ctag

aggc

agag

aaga

ggttc

agat

ctgg

cctg

1995

3695228

DYNCl

YES

cacg

cgct

gcaa

cgtg

tgga

ttctg

gatg

gaga

cttg

tacc

acaa

aggc

ctgc

tgaa

atttg

cagt

ttctg

ctga

atcc

ttgcc

agag

accc

tcgt

cattt

ttgt

LI2

tgca

g

1996

3854016

—NO

taga

tctc

gtcg

ctgg

tatg

cttg

gttc

cgct

cctc

gtttc

ttagt

tgct

tattc

tacc

cgtta

ttcac

tgat

gtta

1997

3980369

FAM15

NO

tcca

tcac

agac

agca

gagc

cggg

cagc

tttct

tatg

ccat

tttct

acac

tgtg

cttc

atga

gtag

gact

ttcttg

cact

agttc

ctat

gact

gagt

ctcc

aaac

t5B

ggttt

ccta

gtag

tccc

ccat

ccct

tcct

ccct

tacc

cagc

tatg

attc

agttg

tctc

tgcc

ctcc

ctct

tacc

ctgc

ctct

gtgt

ttcgg

tgag

agtc

1998

3799919

—NO

tgta

ttaca

caga

gact

accg

caca

aaac

acgg

accc

aatg

ccag

gcaa

gcac

gcgc

ccag

cctg

aacc

tcca

agaa

ctgt

ctt

1999

3032425

—NO

caca

cctg

taag

ctga

ggtg

aagg

agtt

2000

2475245

PPPlCB

YES

aaag

aaag

ctaa

atac

cagt

atgg

tgga

ctga

attc

tgga

cgtc

ctgt

cact

ccac

ctcg

aaca

gcta

atcc

gccg

aaga

aaa

2001

3487

169

DG

KH

YE

Stc

tggg

gata

ccga

aagt

gggt

catg

tgaa

gcga

attc

tcca

g20

0239

5515

5—

NO

aatg

acat

ccct

tttga

gctg

tgga

tggt

g20

0328

2716

0PH

AX

YE

Sca

cggc

aact

gcat

gtgc

acca

gtat

caca

ttatc

gagc

tgttg

aaag

tgtg

gattc

aagt

gaag

aaag

tttttc

tgat

tcag

atga

tgat

agct

gtct

ttgga

aac

gcaa

acga

caga

aatg

tttta

accc

tcct

ccca

aacc

agag

ccttt

tcag

tttgg

ccag

agca

gtca

gaaa

ccac

ctgt

tgct

ggag

gaaa

gaag

atta

aca

acat

atgg

ggtg

ctgt

gctg

cagg

aaca

gaat

caag

atgc

agtg

gcca

ctga

acttg

gtat

cttg

ggaa

tgga

gggc

acta

ttgac

agaa

gcag

acaa

tcc

gaga

ccta

caat

ta

2004

3186

892

—N

Oat

agat

aacg

tttgt

gtgg

cact

cccc

aaga

ctca

ggca

ttgtg

ataa

ctaa

cact

ttcca

tgaa

taat

gtca

taga

attc

tcac

aaac

atcc

tgtg

agat

agac

acta

ttattt

tcaa

cccc

atgt

acat

atga

gaat

actg

agag

ttgga

gaga

ctga

gtaa

catg

ccct

agat

gact

cagc

tagc

aagg

aatg

aaaa

gcac

attc

taa

ctcc

accc

acat

atat

agttc

cagg

atcc

catc

tctc

tacc

tcac

atta

atta

gttc

tata

ccag

cttta

tgttt

ccta

ctag

aatg

tgca

tgttt

taaa

ggct

gag

ctttc

2005

3195536

—NO

tggc

cttc

tgga

cagt

aggt

aggc

atgt

gatc

actg

ttgtc

acta

aacc

tggg

aaat

gattc

ctgg

gtca

gggt

tcat

taat

tgc

2006

3238305

—NO

gtat

tgaa

attc

ctcg

agcc

gctg

ctttt

ctca

ctcc

ataa

ttctg

gcca

gaat

ttggt

actta

aaat

atttt

gtct

aaaa

tatta

caat

agct

actta

agtc

atct

ccc

tgac

tcca

ctct

gttg

tcttt

cagg

gcgt

cgtc

caca

ctgt

agcc

aaag

tgat

ctta

taaa

aaca

taat

tcta

atca

tggc

actc

ttctg

ctta

aaaa

tgttt

taat

ggc

tttcc

gtta

ggtta

aaat

ttaaa

agtc

ctttg

tagc

ctgt

gaga

2007

3744218

VAMP2

NO

acttg

ctgg

aaaa

cggg

gatg

cttg

cccc

tctc

cagg

acta

ttgag

ccca

gaga

gagc

tgtc

ctct

cattg

ggtg

aact

gattg

agga

aggg

tcta

ttgtc

ttttta

aatg

gcac

aattt

taag

ggttt

gagg

gtac

agtc

cctta

acct

gcca

cggg

aggg

ggcc

ccca

aact

ttcttc

cccc

caca

cttc

tggt

tttct

gtgt

ggag

gggg

agca

ggga

tatc

taag

ctgt

ggtg

tgaa

aggg

tagg

agag

atgc

tgga

ggtg

gggg

tgct

gtgt

tttag

accc

ccca

tatta

tccc

agtg

tccc

ctg

cccc

cctc

ttccc

ccac

ccca

tgcc

ccca

attc

tgtg

gcgc

atcc

agat

tgtg

aaaa

tgta

2008

3810033

—NO

gtga

atat

atct

aggt

ccag

cagg

gtct

caga

agca

gatg

ccaa

cctg

aggg

gaat

attta

ccag

atga

2009

3943786

—NO

cagc

agct

gcta

tcca

tcgt

catc

acca

gtgt

catc

atcg

ccat

cccc

atca

tcac

cacc

aaca

ccgc

cacc

cccc

cagc

gaca

cact

agct

gtgg

acac

atc

cttta

cgcc

cttg

aacc

tgag

tttct

acag

ctat

gaag

caag

tccc

atgg

aattt

acag

acca

aacg

ctaa

gtgt

aggg

ctcc

ctgg

gagc

tggt

ctta

tgg

agca

cact

ggca

2010

2321472

—NO

cagt

ccat

gagg

tcca

cttg

tcta

aata

tgtc

acttg

aagt

gcaa

ggta

ccaa

ttgct

cagt

ggct

caaa

atga

ttttc

tggt

tctg

ttgtc

atttc

aaga

gcttc

tcttg

aggg

ttgag

agag

tctg

ttttc

ctaa

gaat

ctgg

ttctc

tcca

tcag

tctc

tgttt

ccac

ctta

tcttc

ctgg

gaag

gtgt

gcttt

ctttg

aggt

gaga

tgtg

aagc

ctgc

ccac

gtgc

agttt

tatg

tcga

attc

caag

tcag

atct

taac

ttggt

actc

ccgg

agcc

tgttg

gaag

tctta

2011

2361272

—NO

gtgc

aaca

tcac

tttga

cttg

atta

ttcttg

ggtc

tgttt

tattt

cccg

ctttt

atttt

gcttt

tgaa

atct

ttttc

cttg

gtgg

atttg

tacg

tgtc

ttcac

taga

tgcc

tca

aatta

agtc

tgac

caca

atcc

tact

ctac

tt

2012

2447714

—NO

tgcc

aact

tctc

ttcac

caca

caat

ctgc

agaa

gc

2013

3175

671

VPS

13A

YE

Sta

tgat

gatg

ccta

taga

tttgg

ggga

aaag

acaa

tata

tttag

tttca

ttcttt

gaag

gttta

caac

gcat

tattt

tattc

actg

aaga

tcca

aggg

tattt

aaag

taac

atat

gaaa

gtga

gaaa

gcag

agtta

gcag

agca

agaa

attg

cagt

ggca

ttaca

agat

gttg

gaat

ttctc

ttgtc

aaca

atta

cacg

aagc

aaga

agta

gcct

atat

a

2014

3517776

—NO

tata

agga

cttc

acag

atag

ctgc

cgtg

gatg

ctg

2015

3626941

___

NO

taat

ttcac

aatg

ggtg

tggg

aggt

tggt

gagt

agat

ggac

taga

ttcaa

aagt

agat

acct

cgct

ctca

ccta

tagc

ctag

cagt

tt2016

2467805

TTC

15

NO

ctcc

aaca

cact

acgt

caga

agga

cccg

g2017

3701421

___

NO

ttgct

ttgtc

ttgtg

atcg

cagc

tcac

ggca

gcct

tgga

ctcg

tggg

cacg

ag2018

3717066

NFl

YES

caga

aagt

gctg

caat

tgcc

tgtg

tca

2019

2476534

___

NO

agat

ggta

caaa

ggtc

gtga

tagg

gctg

2020

2750682

___

NO

ccaa

gatta

ggcc

actg

ccct

gtaa

c2021

2412205

—NO

gggt

taag

ctgg

gaac

catg

tctc

ctgg

ggca

aaat

tttaa

ttcttc

tagc

cact

tgtta

tgtg

atct

caag

caag

gtac

atac

gtct

ctgg

gtct

tttttt

cttta

tct

aaaa

tatg

aaga

gatta

agtg

ttttc

ttaat

tttct

ttcag

ctct

gata

ttatg

tgat

tctg

tgat

taaa

tgac

ctgg

atgt

tgat

aata

catg

cc

2022

3019902

—NO

ctttg

gagt

tttcg

ccca

gatc

agaa

tttta

ttgcc

ttttg

ccgt

agac

tgct

gcaa

gattt

ccag

agca

aaga

gaag

gtat

agtg

ttcct

taat

gtga

gtta

tgaa

gatc

aaaa

taca

gcaa

agag

aaga

tttca

gaga

tttaa

aagt

gata

atttt

tact

gaaa

tttgg

aaat

atgt

ctcc

atat

tttaa

cttta

tttta

taaa

aaag

aatta

ct

Oct

gtttt

ttgaa

atgg

ccaa

gcat

taag

taat

atat

gacc

gtga

atttc

ttgag

ggtg

ggaa

atgt

gact

ggat

tttat

atttc

gattg

tatc

acat

gcag

cctc

2023

3750928

KIAAOl

YES

acac

tatg

tggc

attg

tgct

ttgga

gaag

tgcg

tatc

agaa

cgga

ccta

caga

aagt

ttctg

acct

gtct

gccc

cattc

00

2024

2511032

___

NO

atga

ctga

gtct

tata

gcgg

tgttg

ggca

tagc

a2025

2568632

___

NO

atcc

tttgt

cccg

attg

ggtc

ccag

atac

acaa

aa2026

3039827

___

NO

gagt

ccttc

ctgg

atag

cagc

acca

aag

2027

2437284

Clorf2

YES

cagc

tgcc

accg

gttg

gagg

gctg

g2028

3076362

NO

gcat

acaa

gtct

gccc

agtc

ccag

gaag

aaag

agga

gaga

ccct

gaat

tctg

acct

tttga

tggt

cagg

catg

atgg

aaag

aaac

tgct

gcta

cagc

ttgg

gaga

tttgc

tatg

gaaa

gtct

gcca

gtca

acttt

gccc

ttcta

acca

ccag

atca

atttg

tggc

tgat

catc

tgat

gggg

cagt

ttcaa

tcac

caag

catc

gttc

tct

ttcct

gttc

tgga

atttt

gtttt

ggag

ctct

ttccc

ctag

tgac

cacc

agtta

gtttc

tgag

ggat

ggaa

caaa

aatg

cagc

ttgcc

ctttc

tatg

tggt

gcgt

gtt

cagg

ccttg

acag

atttt

atca

aaag

gaaa

ctat

tttat

ttaaa

tgga

ggct

gagt

ggtg

agta

gatg

tgtc

ttggt

atgg

agga

aaag

ggca

tgct

gcat

cttc

ttcct

gacc

tccg

gggt

ctct

ggcc

ttttg

tttcc

ttgct

cact

gagg

ggtc

tgtc

taac

caag

cagg

cta

2029

3527927

FLJ1035

NO

tgag

tcag

catc

ccca

atttc

tacc

acat

ccag

cact

ccta

ccat

cttg

catg

tacc

ttcct

tcct

gtcc

ccgg

ctac

ttggg

agtc

agct

tcttc

cctc

tccc

aac

7tc

atct

ccct

cttc

t

2030

3889598

...

NO

cagg

tctta

gcgg

tcat

cagg

atga

aggc

ggtg

ggaa

gtgg

agca

acag

agat

ccaa

atat

ggaa

agag

cacg

tgct

gata

ccag

aggc

actg

gaaa

taat

agca

atat

ccga

aagt

ctgc

tcac

cctg

cgtc

attc

cttc

agac

agta

gtcg

ggct

ctat

tc

2031

3735624

MFSDl

NO

ttaaa

atct

gcaa

tact

ggcc

aata

ttcttt

tatc

aaac

agga

gacc

gcag

cttta

aagg

ggga

aaat

gcag

acgt

tgga

taaa

aaca

gcaa

gaaa

tagt

cat

1ttt

catta

atag

gtct

caaa

cagt

ttacg

aaac

agcc

atta

ttatc

2032

2739508

___

NO

ggca

tgtg

tggg

taat

tagt

tctc

acta

tggt

taga

ctcc

tgaa

gtga

gtgg

tcca

agttg

ttagc

gtgc

ttctg

ctct

gtga

ggcc

aggc

cagt

atcc

tgtc

tg2033

3819517

RABIl

YYEE

Sga

catc

gcca

agca

cctg

acct

atga

gaac

gtgg

agcg

ctgg

ctga

agga

gctg

cggg

acca

cgca

gaca

gcaa

catc

B2034

3330082

PTPRJ

NO

gggg

tcag

ctat

gcag

ccca

tcac

gtgt

gtttt

tcat

ctgg

gatg

aaaa

agcc

tggt

tctc

ttttg

aaat

gcttg

attg

tact

tattg

agct

aaac

aagt

cttg

gtg

actg

ttgttg

atttg

cctc

aaaa

gtttt

aagt

cctg

ggttt

tcag

acta

ctgt

gta

2035

3378442

SPTBN

NO

ggcc

acat

tctc

ctaa

tagc

atga

aaca

gtca

gctc

acttt

ctgc

ctcc

tcct

ctta

cact

tccc

tgct

gtcc

actg

cggc

caac

tcag

caca

gtgt

ccttg

aag

2ct

gattg

aggg

tc

2036

2473789

—NO

gcgc

gggc

tttcg

agca

cata

caaa

cctg

atta

caaa

agtc

agat

ttcttt

atttc

gtct

tggg

cacg

tcat

tttaa

cccc

gctc

agcc

tctc

ttttg

tgta

tgaa

act

gaaa

gtaa

tagc

ttctg

ctgt

gcaa

aatg

atta

gagg

aattt

gtga

agcg

cttg

gcaa

cata

ctag

gacc

c

2037

3115627

—NO

ttgag

attta

tgtg

tgtg

ccag

acac

acac

acac

acac

atat

gtac

acaa

gcaa

tttttg

tgtg

tgtg

gctc

aagc

cagg

caga

gaaa

gaca

aata

ctaa

atg

atct

cact

cata

tgtg

aaat

ctaa

aaaa

gttg

atct

caaa

gaag

taga

aagg

agcc

tggt

ggtta

tcag

agtc

tggg

gagg

gggt

tggg

gaga

tattg

gcca

aagg

atat

acaa

tttca

gtta

ggta

ggag

gaat

aagt

tcaa

gaag

tcga

ttttg

acta

tagt

taat

aatg

tgttg

tattc

atga

acaa

ggct

aaga

gagt

ggat

gt

IN)

aaag

tgttc

ttacc

acaa

aaag

gata

acta

catg

aggt

aatg

caca

tgtta

atta

gcta

gattt

agta

attc

cata

atgt

atcc

actg

°2038

2745189

___

NO

tcca

tttct

tttta

ctgc

gtcc

gtcc

ctga

caat

acct

gctg

tttac

tcag

ccct

taac

gttg

2039

3450260

___

NO

aaag

tgat

acat

ttgtg

aggg

agga

gg2040

2656876

—NO

caga

cctta

tctc

atag

ggtg

atta

tgag

catta

gatg

aaat

cgtg

ggtg

aaag

gctc

agta

cagt

gcca

ggta

taca

agaa

gcat

tcag

ttaag

taat

agct

gtta

ttgtta

taac

tgag

gtttt

caca

agcc

gcac

act

2041

2952697

NO

gcta

gtttc

aaag

actg

cgac

cctg

ttttg

aattg

gcttg

tttat

gttg

cgac

ggtg

gctg

gaag

ccag

gcca

accc

aggg

tcag

ctttc

ccaa

atca

gtcg

ccaa

ggcc

cacg

agaa

cagt

agttt

caga

actc

ccag

aaat

aggt

tcaa

agat

gcct

gtcc

tgta

ccag

tcct

gccc

agcc

tcgt

ttttc

ctta

ccac

cctg

actg

cagt

ctta

actc

ctgc

aaac

taat

ttgat

cgct

ctaa

gttta

accg

cgcc

caga

atttc

acttt

tgct

tgct

tggc

ctttg

ctgt

gggt

caca

acag

ccct

tcttg

c

2042

3579

549

WA

RS

YE

Scc

tggc

ctct

gtaa

gcct

gtgt

atgt

tatc

aata

ctgt

ttcttc

ctgt

gagt

tcca

ttattt

ctat

ctct

tatg

ggca

aagc

attg

tggg

taat

tggt

gctg

gcta

acat

tgca

tggt

cgga

taga

gaag

tcca

gctg

tgag

tctc

tccc

caaa

gcag

cccc

acag

tgga

gcct

ttggc

tgga

agtc

catg

ggcc

accc

tgttc

ttgtc

cat

ggag

gact

ccga

gggt

tcca

agta

tact

ctta

agac

ccac

tctg

tttaa

aaat

atat

attc

tatg

tatg

cgta

tatg

gaat

tgaa

atgt

catta

ttgta

acct

agaa

agtg

ctttg

aaat

attg

atgt

gggg

aggt

ttattg

agca

caag

atgt

atttc

agcc

catg

cccc

ctcc

caaa

aaga

aattg

ataa

gtaa

aagc

ttcgt

tata

catt

tgac

taag

aaat

cacc

cagc

tttaa

agct

gcttt

taac

aatg

aaga

ttgaa

caga

gttc

agca

atttt

gatta

aatta

agac

ttggg

ggtg

aaac

tttcc

agttt

actg

aact

ccag

acca

tgca

tgta

gtcc

actc

caga

aatc

atgc

tcgc

ttccc

ttggc

acac

cagt

gttc

tcct

gcca

aatg

accc

taga

ccct

ctgt

cctg

caga

gtca

gggt

ggct

tttcc

cctg

actg

tgtc

cgat

gcca

agga

gtcc

tggc

ctcc

gcag

atgc

ttcat

tttga

ccct

tggc

tgca

gtgg

aagt

cagc

acag

agca

gtgc

cctg

gctg

tgtc

cctg

gacg

ggtg

gact

tagc

tagg

gaga

aagt

cgag

gcag

cagc

cctc

gagg

ccct

caca

gatg

tcta

ggca

ggcc

tca

2043

3703

035

—N

Ocg

atgg

acac

tgat

gccc

acac

aggt

g20

4424

4456

2R

C3H

1N

Otc

caga

tgga

tcgt

tggc

ctaa

atttt

caca

cttc

tccc

ctgt

tcat

ccttt

ttcct

cttc

cctg

cttc

ctgg

gaat

aaaa

ggaa

ctttt

ttaaa

aaaa

ttaat

tagt

ccac

aggt

ctca

ttatc

tttct

ttatg

atta

atct

atga

ctttt

tggt

acaa

gaac

aatg

gaaa

aagt

gaat

taag

gtaa

tgaa

caaa

acct

ttcac

ccac

ttaaa

cattt

tcca

gtttt

gaga

ttcct

cttc

gtgt

ttgtg

gtgt

cttc

ccct

tgtta

cccc

ttctg

ccct

ttttc

tctg

acta

tggt

aattt

ggtc

tttag

gctc

atat

cagt

ctcc

ccga

gaca

ttctg

cagt

catta

tcac

ctttt

tggg

tgga

tttta

ttttg

tttta

ttttg

tttttt

ttaaa

aaaa

taac

ttttta

acat

tggt

gcat

atttg

cttg

ggat

agag

cttg

tgta

attta

ccaa

tcgt

attg

attg

taag

tgat

tgtg

ccct

gcag

aggt

atat

ttaac

aaga

caaa

aata

atct

tggt

taat

aaag

gagc

ccat

gaga

tttga

gtca

ggt

tgta

agtg

aaat

cact

taca

ctttt

ggat

agaa

tttat

actc

ctgc

tctta

taaa

tcag

tggt

agac

ttacc

atttt

ttaaa

gtttt

cttg

cattt

ttttg

tttttt

tattg

cca

cagc

tccc

tattc

tttct

tgcc

tgcc

tcca

cccc

cctg

ttcag

gaaa

aaaa

aaaa

ttgag

cctta

aagt

gaca

gctg

atttt

ttaat

tgct

gaat

tttgt

gaaa

tttta

ctttt

tcca

agtg

tttcc

aact

ttaaa

aaga

gaag

tgaa

gaca

aata

ggttg

gaat

ggtg

aaga

caaa

tgga

ttgga

atttc

acag

gctg

tgaa

taat

tcct

tagg

atct

ggca

aacc

gtga

agtc

ttattt

gaag

acct

tatc

tcct

gaga

gttc

ttttg

gagt

agga

aaaa

gaac

ccta

tttga

aata

gacc

gtttt

tctc

ttgttt

ttaa

tctg

tttaa

tattt

ctga

ttttta

agca

gcttt

2045

3816284

DOTlL

YES

ccag

gtcg

tgct

ccag

gttg

ctgc

tgcc

acca

actg

caaa

catc

acta

tggc

gtcg

agaa

agca

gaca

tccc

ggcc

aagt

atgc

gga

2046

3231694

—NO

atcc

acca

agca

gtgc

gtcc

aggt

g2047

3760111

—NO

gaat

gaac

gcag

agag

tgtc

agtg

ctga

ca2048

3960937

—NO

cagg

caca

ccgc

cttg

aggt

gggc

agtg

ccc

2049

2519659

COL3A

NO

gaaa

gattc

attg

gcat

gcca

cagg

ggat

tctc

ctcc

1

2050

3380965

NO

tcta

accc

ttgag

acac

tgcc

aaca

tccc

tcct

agta

caag

acttt

tcttg

gtgc

ttgct

gtttt

taga

ggag

ttttg

gccc

ttcag

tgttt

gtaa

agct

ctcg

gatc

ctca

gaaa

aaaa

ttcttt

agtg

atta

atttt

gaaa

ttgga

gctg

tttga

ttattt

tgat

taag

aagc

tgat

tttcg

gcct

ggca

cg

2051

3690096

DNAJA

YES

agat

ggga

atga

tttgc

acat

gaca

tata

aaat

agga

cttg

ttgaa

gctc

tatg

tgga

tttca

gttc

acat

ttaag

cacc

ttgat

ggac

gtca

gattg

tggt

gaaa

2ta

ccc

2052

3777917

—YES

agga

tcct

gccg

aaag

gtgc

tcag

tggc

ct2053

3811929

—NO

atgt

atca

ttctc

cata

cacc

tgtg

cctt

2054

2436400

NO

ccag

ccac

gcgt

ccag

cagg

tcag

ggat

t2055

3868616

SHANK

YES

taca

tcat

taag

gaga

agac

agtc

ttgct

gcag

aaga

agga

cagt

gagg

ggttt

gg1

2056

2833315

NO

atct

tttga

ttgct

agcc

cagc

tgct

ttcct

tgtta

tcac

tttgt

ggag

cagg

ctgg

acat

tgac

aatg

agttc

tgag

actg

agtg

gaat

ggga

gacc

cctc

cca

gctg

gtgg

tcga

gctg

ccta

gagc

atgg

tcca

tctg

tttgg

gact

aggg

ttgag

ctcc

2057

2886091

NO

tgac

gaat

ttcgt

ctttc

ttccc

tacg

gtgg

agtc

agtg

ttaaa

cata

caac

aagg

agttc

tggg

gcac

aggc

2058

3146585

RNF19

YES

atgt

ccac

gatg

tgct

gctta

tata

ataa

agat

gaat

gatg

ggag

ctgc

aatc

acat

gaca

tgtg

cA

2059

3271059

—NO

gtga

gata

cttg

acat

gggg

acct

ttac

2060

3589673

___

NO

ttcaa

gaag

ttctg

ggga

caga

ggg

2061

3971336

MBTPS

YES

tcct

tgga

aaaa

cgct

gatg

caga

ctttg

gcac

aaat

gatg

gctg

actc

tccc

tcttc

ttattc

ttcct

cctc

ttcttc

ctct

tcct

cctc

ttcttc

ctct

tcct

cttc

ttc2

atct

tcttc

ctct

tcct

cgct

tcac

aatg

aaca

ggtg

ttaca

agttg

tg

2062

3304025

—NO

gtat

gtga

taag

tattt

ggat

ttgag

agta

gacc

tttca

tagt

gagg

ctta

tcag

gttg

aggg

gagg

tgat

gact

ggaa

atat

attta

tttat

tttaa

atcc

cact

ttggc

tttag

taaa

atct

gaat

atgt

gtgc

atttc

tagt

ttctta

cacc

aaat

gtag

gttc

cgta

agttc

atgc

aagt

acag

tggg

tc

2063

3350758

PAFAH

YES

agac

aaag

agcc

tgat

gtac

tgttc

gtgg

gaga

ctcc

atgg

tgca

gtta

atgc

agca

at1B2

2064

3921733

—NO

cagt

gtcg

ctac

aggg

gatc

tctc

aggc

tcac

aacg

ggcc

actc

ctct

aggg

aagt

tctg

gtct

catc

atga

tcct

tgttt

ggtc

tcac

tccc

catg

tcct

tctc

tgt

ccct

cctc

caac

tgcc

attta

tttat

ttaac

tgaa

aaag

tacc

aatc

accc

acat

aggc

atga

2065

2361637

NO

acag

gagc

caat

gccc

aatc

atag

c2066

2625412

—NO

acca

cctg

ggta

ttgaa

gccc

tata

aaaa

cact

ttcta

ctta

cctta

atat

agtc

tggc

gttg

ctgg

gacc

tcac

agtg

ttcttt

caca

ctttt

tatg

taac

ttagg

aac

tgaa

atac

cact

catg

cattt

gttc

taaa

g

2067

2737704

NO

gattg

ctat

ggaa

gtac

tgag

tccc

tgaa

ggag

agac

aagg

tgca

ggaa

gccc

caat

cgcc

aggc

catc

gatg

aaat

tgtg

gagg

gcat

cgca

gagc

gtta

tcat

ccag

gcaa

tcgt

ccct

att

2068

2795252

___

NO

gttc

ggat

gattt

cacg

ggag

cagc

2069

3203541

AQP7

YES

gctg

tgac

ctttg

ctaa

ctgt

gcgc

tggg

ccgc

g2070

3510917

—NO

aaga

ccag

ggta

atca

taga

actg

ccaa

gcag

aaag

aaat

gtag

aatg

tagc

agtg

gtgt

ggag

accc

gtgg

ctga

cagg

tggt

ggtc

ttcat

atag

gct

gagg

gaca

ggct

agat

gcat

gtca

agtg

gc

2071

3670551

—NO

gagc

tcca

ggga

tatc

tcttc

tgca

cattc

ttcca

gagc

agtg

catc

tctc

ttctg

gttg

tttgt

acac

ccttc

tttta

ctct

cctta

ttatc

ctct

ccca

tgttc

attc

agt

acat

actta

gtga

gtgt

tcac

caga

tgct

tagc

acct

gggg

tata

c

2072

3729159

DHX40

NO

gcct

atgg

cagg

attc

tttct

tgaa

ttaat

atta

atcc

ttaaa

ttgat

ttttc

tggg

atta

taca

aattc

ctttt

tata

taaa

agta

tattg

tttaa

aaca

gtag

ctat

agc

catta

acca

aagg

acag

atga

tata

tata

tata

tgat

atat

atat

atat

ataa

gttc

tttttt

agct

gtac

ctac

gtac

ttata

tcag

cacc

atgt

atgt

aggt

gtga

tagt

acttt

caaa

cagc

gcct

ccac

ctgg

ccta

ctct

gtta

tttcc

acct

gtttg

ggta

gggc

cattt

aact

tcca

ttatg

ccaa

acttg

ggat

ggga

ttttc

gaag

caga

caac

acta

tttca

tcgt

gtttc

aaat

tgga

acct

tgag

gcta

gtta

gtat

caca

ct

2073

2969

482

CD

C2L

YE

Stg

tattt

gccg

gctg

ccag

attc

cata

cccc

aaac

gaga

attc

ctta

atga

agat

620

7430

4011

6SN

X13

YE

Stg

gcaa

cctta

tttta

ctac

acgc

attg

taga

tgac

tttgg

caca

cact

tacg

agta

ttcag

aaag

gctc

aaca

2075

3819

122

LO

ClO

OY

ES

gagg

tggc

taga

aaac

ggca

agaa

c12

9391

2076

2359763

—N

Oac

ctgc

gtca

cacc

ctgg

ctag

tgac

ccag

tcag

acgt

gctg

ggga

ccct

ggct

gacc

acct

gtac

cagg

ggca

agga

agga

agga

gagg

ggag

catt

gtga

agca

gggc

agga

tgac

tcttg

aagg

tgga

gaca

ggcc

ctgg

acag

ctct

ggga

ccct

taat

ggtg

gcag

c

2077

2969302

WASFl

YE

Sgg

tttga

taga

aaat

cgcc

ctca

gtca

ccag

ctac

aggc

agaa

cacc

tgtg

tttgt

2078

2330410

Clorfll

NO

gaag

ctgg

tccc

acgg

aaag

tggt

atct

cggg

aatc

ag

3

2079

3265

461

FAM

16N

Otc

tagg

tggg

gaac

tgac

tgat

aacc

cttg

gcag

caat

caaa

gtgc

cagt

ggct

cctc

gatg

tttac

atttt

tttct

atttt

gttc

agtc

ttttg

tttta

aatg

attc

taOBl

aaga

gatta

aaga

aaac

agag

tttta

aatg

tcct

attta

catg

ttaaa

ggat

ttggg

gaaa

ttggg

tatg

tatg

tgaa

tggg

tgta

catg

tagg

aacc

tgta

gttc

agca

aagc

tgcg

ctgg

gcac

agca

tgct

tgta

cttg

attg

acaa

aatc

gtgt

ttgcc

agtc

cact

ttcta

tttttc

cttta

agtg

atgc

tgat

cact

caaa

taat

gct

tttaa

gcta

ttgttt

gtttt

tattt

gaca

tgtta

agcc

gcag

cact

ttcttc

ttcat

ctttc

cattt

actg

atat

ttggg

ggaa

cagg

ctat

caaa

ggttc

cggc

ttgaa

ggg

aact

gtca

ctac

2080

3735

093

LO

C64

3N

Ogc

cacc

gact

tcgt

gcag

gaga

tgcg

c

008

2081

2402

500

PAFA

HYYE

ESS

ggca

acat

tgac

atga

gccg

tgtg

gctg

tgat

ggga

cattc

atttg

gagg

ggcc

acag

ctat

t2

2082

3552

152

ME

G3

YE

Stc

ttcaa

ccca

ctgc

ttcct

gact

cgct

ctac

tccg

tgga

agca

cgct

caca

2083

2736

402

NO

atta

taag

gtat

gata

tggc

ttccc

aattg

tcaa

agaa

ttaaa

atgc

tcat

tagg

agag

gagt

gact

gcttc

tccc

tttag

taga

aaaa

caat

tcaa

actc

aggt

tac

caat

taca

atac

acaa

acta

aaac

agtta

tgttg

agcc

ggga

aacc

gtct

tcttg

tagg

ctat

cttc

tagc

acca

aata

atgc

ccac

atga

tttct

ggct

gaa

ggcc

a

2084

2751

960

NO

gcttc

cttc

gtga

attc

taac

cgta

ccgt

tact

gtgt

ttgag

gatc

actg

gcag

ccga

gctc

tgag

tggg

gaac

tgag

ataa

gaaa

ggtg

ttgtc

atga

taac

a

cctg

gaca

gctg

catc

ccac

agac

tatg

ggag

tgcc

agga

aact

ggct

acct

caca

gcag

agta

gaga

aaat

ggaa

ataa

acac

aaat

ataa

gcttt

tcag

tgag

ctgt

gggt

caga

gaag

gcca

caag

tggt

ctgg

caga

tcat

ggtg

cagc

tcttt

gtttc

atga

gcta

cgtg

cagc

agta

gtttt

tatg

agct

ctttt

tgta

gct

ttcca

gccc

tagg

attc

agcc

atgg

taa

2085

3024231

—N

Otg

ccca

gaaa

cgac

cattt

tgga

caat

ctca

tcca

gtttt

acgc

ttgttt

tattc

agaa

agag

aatc

acct

atcc

tcttc

acat

c

2086

2928814

—N

Ota

agga

aattg

ggttg

tcac

cact

ggct

ttgag

taat

tcgt

tttgt

ctat

gcaa

gctg

tcttc

atac

gaaa

aagg

ttttc

atac

tata

tcca

gtcc

c

2087

3166955

NFXl

YE

Sgt

tgaa

gtcg

aaac

atcc

cact

ggac

at

2088

3829651

KIAA03

YE

Scc

tgac

tgtg

gtgc

aagt

ccat

ttcca

gtttt

tgac

tcat

gcgt

taca

gaag

gtcc

agcc

ggtg

gctc

actc

ttgct

ttgct

gagg

tcat

cgtg

cc

55

2089

3709186

JMJD3

YE

Sgt

cagg

cagc

tgta

agcg

gcga

caga

ag

2090

2947628

—N

Oct

gttg

acttc

agag

tcga

gtgt

gag

2091

3820638

SLC44A

NO

ccca

gtga

tggc

cacg

tcttg

tttct

agaa

tccc

ttcct

ttgca

caag

ccat

attc

tgaa

ctct

taat

tcct

tccc

ttaac

ttcaa

tccc

tatg

tctc

ctgt

ccta

cctc

2at

ggttt

tcct

ggcc

ccac

acct

gatg

ctca

gagc

ccac

tgtg

aacc

cctg

gtgc

ctct

ttttg

gact

cggt

tc

2092

3823

661

APl

Ml

NO

cagc

ctca

gact

ttttc

ccac

tgag

ggtc

caga

gagc

gggg

ccac

gtgt

cacc

cacg

tctg

cgct

tggt

cacc

cgtc

ctcc

ccac

cctg

tgtg

tgttt

atgt

cat

agtta

catta

a

2093

4038647

—NO

aggt

ctcc

gcttt

cctg

gaaa

tcca

gacc

c2094

2543897

—_

NO

agct

ctgg

gtga

gact

tgtc

ttccg

gggg

ctg

2095

2353902

—NO

ctct

gatta

ggtc

ttgtg

ccca

ttgttg

aacc

aaat

gctg

tgct

tagg

agga

tggg

acat

gttc

tttttg

ttttg

ctta

gtta

gggc

ctgg

ctct

ggag

ccag

gaga

gggg

agga

ggaa

atgt

tgct

ggat

gtaa

gtta

gcac

tgat

acta

atta

ttcta

acaa

tgat

taat

agtta

gaat

ggct

gggt

gcag

tggc

acat

agtc

ccag

ctcc

gcag

gagg

ttgag

atgg

gagg

atcg

cctg

gggc

cagg

agtc

caag

gcta

tggg

gcac

catg

atca

tga

2096

3190953

PPP2R4

YES

cact

ttgtg

gatg

agaa

ggcc

gtga

atga

gaac

caca

agga

ct2097

3922999

PKNOX

YES

gcgc

ccgg

ccga

gaat

gaca

tctta

a1

2098

3701615

NO

atgg

acag

cttc

aaag

ggca

gtttg

gggg

tttct

gttta

ttttc

ctgt

atgt

tctg

gtca

cctc

aatc

atct

aacc

agaa

gaac

tggc

ccaa

aatta

ggca

caag

aaaa

aagg

aaaa

agtc

tagc

cctg

ccac

ataa

ctcc

tgga

actg

gttg

caga

aact

gaac

2099

2528729

NO

ggga

agac

acga

aggg

aggg

cgct

g2100

3188305

.._

NO

ggat

agct

tcta

ttgtg

gacg

tgga

atcc

2101

3578798

...

NO

agat

ctac

tcct

ggat

gcgg

gtac

agga

cagc

atcc

ccag

actg

tttgt

aaag

tctc

atgt

gata

catg

gagg

gcag

gcct

2102

3810041

—NO

agca

gaag

caaa

cggg

ggtg

tctc

agga

gggg

gccc

cgttt

ccttc

ttgta

aagc

tgct

ccca

ccca

cagc

caca

ctcc

attc

agtc

aggt

ttatg

tgct

gtt

cttc

cttg

tccc

ttatg

aggt

agaa

ccat

cacc

ttgcg

tgca

aagc

agct

ta

2103

2520084

MGC13

NO

ggtg

tctg

tcgg

tcttt

gcttg

tcag

ctgt

057

2104

2615285

_-_

NO

gtgt

ttgtg

ctca

atgt

aaga

gcaa

ggaa

ggtg

cggg

aaga

tgag

gggg

atga

ggcg

cagg

agta

cagg

gctg

ttattc

a2105

2676383

NEK4

YES

tggt

agag

tggt

ttgta

caga

tcgc

catg

gcttt

gcag

2106

3337536

.-_

NO

aggc

ttcttg

caca

ggca

gaag

gggc

t2107

3670582

—NO

tacg

tgcc

caag

aatc

aatc

caat

ccaa

ctga

taac

atttt

ctct

gaag

atag

ctgc

ctct

tcaa

atac

tggt

acag

agat

tcaa

gaag

ctgt

acca

caga

cca

tcag

tt

2108

2359853

NO

ccca

tttttc

atta

ggtc

cagg

tgta

tcca

aatg

ttgcc

a2109

3349998

___

NO

tgat

gtgg

cccc

gattg

caga

attg

agttg

gagg

ctga

agca

tgtg

agct

ctga

tcct

tgcc

2110

3431977

NO

cttc

cctc

tgga

agac

taac

atgt

actg

ctga

agtc

ttgttc

agtg

tcct

tcta

gccc

caga

ctttg

cagc

ctac

caac

atgg

actg

agac

aggg

aaag

cgtg

ggca

agtg

agttc

cata

ctct

aattt

tcct

acag

aagc

atcc

taag

tggt

gtgt

gggt

tctc

agat

caag

tcac

aaac

acat

tcac

agcc

catg

atat

cgta

caa

cact

acttt

ttagt

tcaa

atta

atta

tgag

taac

aaca

gact

atct

gcca

aaat

aggg

agct

gca

2111

2482

372

AC

YP2

YE

Sag

ctag

gaaa

atag

gagt

ggttg

gctg

2112

2619

332

SS18

L2

YE

Sca

ttgca

gatg

ccag

tcca

acca

gcac

2113

3810

037

—N

Occ

cgtg

gctc

taaa

agta

ttatc

cgaa

atca

acca

gtca

cccc

tttca

ccttc

tctc

agttt

aaaa

atgg

atcc

agtg

cata

ccca

atag

2114

2944

959

—N

Ogt

agga

atca

aaca

tagc

gcca

tcta

tctg

ctttt

tata

ttatc

ctac

acta

tttta

aaaa

ctgc

tcaa

cagt

ctta

taca

gaaa

tcttt

aaaa

gata

gaca

ggat

aaca

tgct

atat

taac

ccca

ccat

tgaa

ataa

tcca

acac

catc

acga

ttccg

atta

agag

aaga

aaaa

aatc

tttttt

ttttc

tttttt

tttct

tttttt

ctttt

tttttt

tccg

aaa

ccac

tcgc

cctc

cact

gact

gccc

ctgt

acca

catc

aaac

agtc

tcct

ctcc

tcca

cgcc

tccg

gggt

ctgg

gaag

tctc

acct

cact

gattt

c

Table 4 . Differentially expressed RNA transcripts used to plot hierarchical clustering and

expression matrix ('heat map') in Figure IB. The 526 RNA transcripts represent a subset of the

differentially expressed transcripts (Table 3) between patients in the three clinical status groups

(i.e., 'SYS', 'PSA' and 'NED') disease using linear regression and a p-value cut-off of p<0.01 .

Weighting factors were from the regression coeffecient values; positive and negative values

indicated transcripts correlated to increased expression in 'SYS' and 'NED' disease, respectively

with intermediate expression values in the 'PSA' disease group. Weighting factors were used to

derive 526-metagene values in Figure 2 .

SEQ SEQ SEQ SEQ SEQ

ID Weights ID Weights ID Weights ID Weights ID Weights

N o N o N o N o N o

1 -6.08 57 -3.6 113 -3.3 169 -3.06 925 4.36

2 -5.71 58 -3.6 114 -3.3 170 -3.06 926 4.36

3 -5.68 59 -3.59 115 -3.27 171 -3.06 927 4.33

4 -5.39 60 -3.58 116 -3.27 172 -3.05 928 4.27

5 -5.26 6 1 -3.58 117 -3.26 173 -3.05 929 4.27

6 -4.84 62 -3.58 118 -3.26 174 -3.05 930 4.18

7 -4.7 63 -3.58 119 -3.26 175 -3.05 931 4.17

8 -4.68 64 -3.58 120 -3.25 176 -3.04 932 4.13

9 -4.66 65 -3.57 121 -3.25 177 -3.03 933 4.12

10 -4.55 66 -3.57 122 -3.24 178 -3.03 934 4.08

1 1 -4.53 67 -3.57 123 -3.24 179 -3.03 935 4.08

12 -4.47 68 -3.55 124 -3.23 180 -3.02 936 4.07

13 -4.4 69 -3.52 125 -3.23 181 -3.02 937 4.07

14 -4.37 70 -3.51 126 -3.22 182 -3.02 938 4.04

15 -4.32 7 1 -3.5 127 -3.22 183 -3.01 939 4.03

16 -4.27 72 -3.5 128 -3.22 184 -3.01 940 4.03

17 -4.23 73 -3.49 129 -3.22 185 -3 941 4.02

18 -4.2 74 -3.48 130 -3.22 186 -3 942 4.02

19 -4.18 75 -3.48 131 -3.21 187 -2.96 943 4.01

20 -4.1 76 -3.47 132 -3.21 188 -2.96 944 3.97

2 1 -4.09 77 -3.47 133 -3.21 189 -2.96 945 3.95

22 -4.06 7 8 -3.47 134 -3.2 190 -2.95 946 3.95

23 -4.03 79 -3.47 135 -3.19 191 -2.95 947 3.95

24 -4.02 80 -3.46 136 -3.19 192 -2.95 948 3.95

25 -4.01 8 1 -3.45 137 -3.19 193 -2.94 949 3.92

26 -4 82 -3.45 138 -3.19 194 -2.94 950 3.92

27 -3.96 83 -3.44 139 -3.18 195 -2.94 951 3.9

28 -3.95 84 -3.43 140 -3.17 196 -2.93 952 3.89

29 -3.95 85 -3.43 141 -3.17 197 -2 92 953 3.88

30 -3.95 86 -3.43 142 -3.16 198 -2 92 954 3.84

3 1 -3.95 87 -3.43 143 -3.16 199 -2 92 955 3.84

32 -3.92 88 -3.42 144 -3.15 200 -2 92 956 3.83

33 -3.91 89 -3.41 145 -3.14 201 -2.91 957 3.8

34 -3.88 90 -3.41 146 -3.14 202 -2.91 958 3.8

35 -3.86 9 1 -3.4 147 -3.13 203 -2.9 959 3.8

SEQ SEQ SEQ SEQ SEQ

ID Weights ID Weights ID Weights ID Weights ID Weights

N o N o N o N o N o

36 -3.85 92 -3.4 148 -3.13 204 -2.89 960 3.79

37 -3.8 93 -3.39 149 -3.12 205 -2.89 961 3.77

38 -3.8 94 -3.38 150 -3.12 206 -2.88 962 3.76

39 -3.79 95 -3.36 151 -3.11 207 -2.88 963 3.75

40 -3.74 96 -3.36 152 -3.11 208 -2.87 964 3.74

4 1 -3.73 97 -3.36 153 -3.11 209 -2.87 965 3.72

42 -3.73 98 -3.36 154 -3.11 210 -2.87 966 3.71

43 -3.71 99 -3.35 155 -3.1 211 -2.86 967 3.71

44 -3.7 100 -3.35 156 -3.1 212 -2.85 968 3.71

45 -3.7 101 -3.35 157 -3.09 213 -2.85 969 3.7

46 -3.7 102 -3.34 158 -3.09 914 5.32 970 3.7

47 -3.68 103 -3.34 159 -3.09 915 5.27 971 3.69

48 -3.67 104 -3.34 160 -3.08 916 4.82 972 3.69

49 -3.66 105 -3.33 161 -3.08 917 4.64 973 3.68

50 -3.66 106 -3.33 162 -3.08 918 4.59 974 3.67

5 1 -3.65 107 -3.32 163 -3.07 919 4.54 975 3.66

52 -3.65 108 -3.32 164 -3.07 920 4.49 976 3.65

53 -3.64 109 -3.31 165 -3.07 921 4.45 977 3.64

54 -3.64 110 -3.31 166 -3.07 922 4.43 978 3.63

55 -3.63 111 -3.3 167 -3.07 923 4.38 979 3.62

56 -3.62 112 -3.3 168 -3.07 924 4.38 980 3.62

981 3.61 1037 3.39 1093 3.18 149 3.04 1205 2.9

982 3.61 1038 3.39 1094 3.18 150 3.04 1206 2.89

983 3.6 1039 3.39 1095 3.18 151 3.04 1207 2.89

984 3.6 1040 3.38 1096 3.18 152 3.03 1208 2.89

985 3.59 1041 3.38 1097 3.18 153 3.03 1209 2.89

986 3.59 1042 3.38 1098 3.17 154 3.03 1210 2.88

987 3.58 1043 3.38 1099 3.17 155 3.03 1211 2.88

988 3.58 1044 3.37 1100 3.17 156 3.02 1212 2.88

989 3.57 1045 3.37 1101 3.16 157 3.02 1213 2.87

990 3.57 1046 3.37 1102 3.16 158 3.02 1214 2.86

991 3.56 1047 3.36 1103 3.16 159 3.01 1215 2.86

992 3.56 1048 3.35 1104 3.16 160 3.01 1216 2.86

993 3.55 1049 3.35 1105 3.15 161 3.01 1217 2.86

994 3.55 1050 3.35 1106 3.15 162 3.01 1218 2.86

995 3.55 1051 3.34 1107 3.15 163 3.01 1219 2.85

996 3.55 1052 3.34 1108 3.15 164 3.01 1220 2.85

997 3.54 1053 3.33 1109 3.14 165 3 1221 2.85

998 3.54 1054 3.33 1 10 3.14 166 3 1222 2.85

999 3.54 1055 3.33 1 1 1 3.14 167 3 1223 2.85

1000 3.54 1056 3.32 1 12 3.14 168 3 1224 2.85

1001 3.54 1057 3.31 1 13 3.13 169 3 1225 2.85

1002 3.53 1058 3.31 1 14 3.13 170 2.99 1226 2.85

1003 3.53 1059 3.31 1 15 3.12 171 2.99

1004 3.53 1060 3.31 1 16 3.12 172 2.99

1005 3.53 1061 3.3 1 17 3.12 173 2.99

1006 3.53 1062 3.3 1 18 3.11 174 2.99

1007 3.53 1063 3.3 1 19 3.11 175 2.99

1008 3.52 1064 3.29 1 20 3.11 176 2.99

SEQ SEQ SEQ >EQID Weights ID Weights ID Weights ID Weights

N o N o N o No1009 3.52 1065 3.29 1121 3.11 177 2.98

1010 3.51 1066 3.29 1122 3.1 178 2.98

1011 3.51 1067 3.28 1123 3.1 179 2.97

1012 3.5 1068 3.27 1124 3.1 180 2.97

1013 3.49 1069 3.27 1125 3.09 181 2.97

1014 3.49 1070 3.27 1126 3.09 182 2.97

1015 3.48 1071 3.27 1127 3.09 183 2.96

1016 3.48 1072 3.26 1128 3.09 184 2.96

1017 3.48 1073 3.26 1129 3.09 185 2.96

1018 3.48 1074 3.25 1130 3.08 186 2.96

1019 3.47 1075 3.24 1131 3.08 187 2.96

1020 3.46 1076 3.24 1132 3.08 188 2.96

1021 3.45 1077 3.24 1133 3.08 189 2.95

1022 3.45 1078 3.22 1134 3.08 190 2.94

1023 3.44 1079 3.22 1135 3.07 191 2.94

1024 3.44 1080 3.22 1136 3.07 192 2.94

1025 3.44 1081 3.21 1137 3.07 193 2.94

1026 3.43 1082 3.21 1138 3.06 194 2.93

1027 3.43 1083 3.2 1139 3.06 195 2.93

1028 3.42 1084 3.2 1140 3.06 196 2.93

1029 3.41 1085 3.2 1141 3.06 197 2.93

1030 3.41 1086 3.2 1142 3.05 198 2.93

1031 3.41 1087 3.2 1143 3.05 199 2.92

1032 3.41 1088 3.19 1144 3.05 200 2.92

1033 3.4 1089 3.19 1145 3.05 201 2.91

1034 3.4 1090 3.19 1146 3.05 202 2.91

1035 3.4 1091 3.19 1147 3.04 203 2.91

1036 3.39 1092 3.19 1148 3.04 204 2.91

Table 5 . Differentially expressed RNA transcripts used to plot hierarchical clustering and

expression matrix ('heat map') in Figure 1C. The 148 RNA transcripts represent a subset of the

most differentially expressed transcripts between patients with clinically significant 'recurrent'

(i.e., 'SYS') and 'non-recurrent' (i.e., 'PSA' and 'NED') disease. Weighting factors were from

the test statistic values; positive and negative values indicated transcripts correlated to increased

expression in recurrent and non-recurrent disease, respectively. Weighting factors were used to

derive 148-metagene values, which were converted by scaling and normalizing into 'POP' scores

depicted in Figure 7 .

SEQ Weights SEQ Weights SEQ WeightsID No ID No ID No

1 -4.1 925 3.04 1291 2.99

2 -4.21 926 4.61 1299 3.74

3 -5.48 927 3.79 1300 3.33

4 -3.04 933 3.24 1304 3.14

6 -3.73 934 3.65 1311 3.66

8 -3.88 935 3.64 1314 3.95

14 -3.78 939 4.2 1318 3.9

20 -3.14 941 4.14 1320 3.45

32 -3.87 944 3.72 1324 3.31

33 -3.75 945 4.03 1330 3.02

36 -4.93 947 4.44 1335 4.35

42 -3.46 949 3.77 1341 3.7

45 -3.1 954 4.34 1344 2.93

46 -4.14 960 3.54 1346 3.51

60 -5.72 968 3.84 1357 3.82

63 -4.79 970 3.5 1367 3.35

65 -3.82 971 4.68 1369 3.75

66 -4.02 974 3.63 1372 3.07

67 -3.37 978 5.27 1375 3.17

69 -3.25 986 2.59 1383 3.67

79 -3.1 999 4.74 1390 3.49

86 -3.57 1004 4.5 1395 3.19

88 -4.54 1005 3.62 1402 3.45

96 -3.68 1014 4.86 1416 3.29

100 -3.63 1022 6.29 1425 3.73

104 -2.93 1023 4.08 1443 2.97

115 -3.29 1031 3.75 1453 3.01

129 -3.91 1032 3.49 1469 3.02

130 -3.32 1039 3.44 1474 3.52

181 -3.27 1045 3.41 1489 3.66

182 -3.37 1052 3.28 1503 3.19

187 -3.56 1060 4.48 1527 3.25

189 -3.44 1062 4.1 1551 3.41

194 -2.09 1080 3.97 1598 3.26

217 -4 1093 4.02 1624 2.91

225 -4.01 1095 3.77 1689 2.82

SEQ Weights SEQ Weights SEQ WeightsID No ID No ID No241 -4.16 101 3.55

265 -3.86 108 3.39

280 -4.02 117 3.97

293 -3.36 123 4.03

295 -3.57 124 3.45

334 -3.36 126 3.25

355 -3.44 132 3.51

387 -3.73 146 3.78

400 -3.17 147 3.37

437 -4.02 153 3.71

445 -3.14 164 3.54

460 -3.36 167 3.6

468 -3 194 3.2

536 -3.65 208 3.35

592 -2.7 218 3.56

596 -2.79 219 2.96

684 -2.75 233 3.44

915 3.78 234 3.86

920 4.36 248 3.56

923 3.23 261 3.19

Table 6 . Genes identified in a literature search as being correlated to clinical outcome or

prognosis in prostate cancer patients. Indicated are the gene name and HNGC gene symbol.

Gene Name SymbolAminoadipate-semialdehyde dehydrogenase AASDHATP-binding cassette, sub-family A (ABCl), member 5 ABCA5ATP-binding cassette, sub-family B (MDR/TAP), member 1 ABCBlATP-binding cassette, sub-family C (CFTR/MRP), member

ABCC22ATP-binding cassette, sub-family C (CFTR/MRP), member

ABCC44ATP-binding cassette, sub-family C (CFTR/MRP), member

ABCC55ATP-binding cassette, sub-family G (WHITE), member 2 ABCG2V-abl Abelson murine leukemia viral oncogene homolog 1 ABLlAcetyl-Coenzyme A carboxylase alpha ACACAAcyl-Coenzyme A oxidase 1, palmitoyl ACOXlAcid phosphatase 2, lysosomal ACP2Acid phosphatase, prostate ACPPActin, gamma 2, smooth muscle, enteric ACTG2Aspartoacylase (aminocyclase) 3 ACY3AF4/FMR2 family, member 3 AFF3AF4/FMR2 family, member 4 AFF4Aryl hydrocarbon receptor AHRAbsent in melanoma 2 AIM2V-akt murine thymoma viral oncogene homolog 2 AKT2Aminolevulinate, delta-, synthase 1 ALASlActivated leukocyte cell adhesion molecule ALCAMAldehyde dehydrogenase 1family, member A2 ALDH 1A2Anaplastic lymphoma kinase (Ki- 1) ALKArachidonate 12-lipoxygenase ALOX 12Arachidonate 15-lipoxygenase, type B ALOX 15BAlpha-methylacyl-CoA racemase AMACRAlanyl (membrane) aminopeptidase (aminopeptidase N,aminopeptidase M, microsomal aminopeptidase, CD 13, ANPEPp 150)Anthrax toxin receptor 2 ANTXR2Annexin A2 ANXA2APEX nuclease (multifunctional DNA repair enzyme) 1 APEXlAndrogen receptor (dihydrotestosterone receptor; testicularfeminization; spinal and bulbar muscular atrophy; Kennedy ARdisease)V-raf murine sarcoma 361 1 viral oncogene homolog ARAFAmphiregulin (schwannoma-derived growth factor) AREGAT rich interactive domain 4A (RBPl -like) ARID4AArmadillo repeat containing 5 ARMC5Aryl hydrocarbon receptor nuclear translocator ARNTN-acylsphingosine amidohydrolase (acid ceramidase)-like ASAHLATPase family, AAA domain containing 2 ATAD2Activating transcription factor 1 ATFl

Gene Name SymbolAtaxia telangiectasia mutated ATMAtrophin 1 ATNlATP synthase, H+ transporting, mitochondrial F l complex,

ATP5Ddelta subunitATP synthase, H+ transporting, mitochondrial F O complex,

ATP5Jsubunit F6Aurora kinase A AURKAAurora kinase B AURKBAXL receptor tyrosine kinase AXLBeta-2-microglobulin B2MBCL2-antagonist of cell death BADBAIl -associated protein 2-like 2 BAIAP2L2BCL2-antagonist/killer 1 BAKlBRCAl associated protein- 1 (ubiquitin carboxy-terminal

BAPlhydrolase)BRCAl associated RING domain 1 BARDlB-cell CLL/lymphoma 2 BCL2BCL2-like 1 BCL2L1B-cell CLL/lymphoma 3 BCL3Breakpoint cluster region BCRBCSl -like (yeast) BCSlLBiglycan BGNBaculoviral IAP repeat-containing 2 BIRC2Baculoviral IAP repeat-containing 3 BIRC3Baculoviral IAP repeat-containing 5 (survivin) BIRC5Baculoviral IAP repeat-containing 7 (livin) BIRC7Bloom syndrome BLMBMIl polycomb ring finger oncogene BMIlBone morphogenetic protein 4 BMP4BoIA homolog 2 (E. coli) BOLA2V-raf murine sarcoma viral oncogene homolog B 1 BRAFBreast cancer 1, early onset BRCAlBreast cancer 2, early onset BRCA2BTB (POZ) domain containing 14B BTBD 14BBruton agammaglobulinemia tyrosine kinase BTKBUB 1budding uninhibited by benzimidazoles 1homolog

BUBl(yeast)Chromosome 15 open reading frame 33 C15orf33Chromosome 17 open reading frame 56 C17orf56Chromosome 17 open reading frame 57 C17orf57Chromosome 1open reading frame 115 Clorfl l5Chromosome 1open reading frame 77 Clorf77Chromosome 2 open reading frame 33 C2orf33Chromosome 2 open reading frame 37 C2orf37Chromosome 3 open reading frame 14 C3orfl4Chromosome 8 open reading frame 32 C8orf32Chromosome 8 open reading frame 53 C8orf53Chromosome 8 open reading frame 76 C8orf76Calcium channel, voltage-dependent, beta 4 subunit CACNB4Calmodulin binding transcription activator 1 CAMTAl

Gene Name Symbol

Caspase 2, apoptosis-related cysteine peptidase (neuralprecursor cell expressed, developmentally down-regulated CASP22)Caspase 3, apoptosis-related cysteine peptidase CASP3Caspase 8, apoptosis-related cysteine peptidase CASP8Caveolin 1, caveolae protein, 22kDa CAVlCas-Br-M (murine) ecotropic retroviral transforming

CBLsequenceCholecystokinin CCKCyclin A2 CCNA2Cyclin B l CCNBlCyclin C CCNCCyclin D l CCNDlCyclin E l CCNElCyclin H CCNHCD34 molecule CD34CD38 molecule CD38CD40 molecule, TNF receptor superfamily member 5 CD40CD44 molecule (Indian blood group) CD44CD59 molecule, complement regulatory protein CD59CD69 molecule CD69CD9 molecule CD9Cell division cycle 2, G l to S and G2 to M CDC2Cell division cycle 25 homolog A (S. pombe) CDC25ACell division cycle 25 homolog B (S. pombe) CDC25BCell division cycle 25 homolog C (S. pombe) CDC25CCDC42 effector protein (Rho GTPase binding) 5 CDC42EP5Cadherin 1, type 1, E-cadherin (epithelial) CDHlCadherin 11, type 2, OB-cadherin (osteoblast) CDHI lCadherin 13, H-cadherin (heart) CDH 13

Cyclin-dependent kinase 10 CDKlOCyclin-dependent kinase 2 CDK2Cyclin-dependent kinase 4 CDK4Cyclin-dependent kinase 6 CDK6Cyclin-dependent kinase 7 CDK7Cyclin-dependent kinase 9 CDK9Cyclin-dependent kinase inhibitor IA (p21, Cipl) CDKNlACyclin-dependent kinase inhibitor IB (p27, Kipl) CDKNlB

CDKN2A interacting protein N-terminal like CDKN2AIPNL

Cyclin-dependent kinase inhibitor 2C (pi 8, inhibits CDK4) CDKN2CCyclin-dependent kinase inhibitor 3 (CDK2-associated dual

CDKN3specificity phosphatase)CCAAT/enhancer binding protein (C/EBP), alpha CEBPACentrosomal protein 135kDa CEP 135Centrosomal protein 7OkDa CEP70Chromatin assembly factor 1, subunit A (pi 50) CHAFlACHKl checkpoint homolog (S. pombe) CHEKlChromogranin A (parathyroid secretory protein 1) CHGAChromatin accessibility complex 1 CHRACl

Gene Name SymbolCeroid-lipofuscinosis, neuronal 5 CLN5Clusterin CLUCalponin 1, basic, smooth muscle CNNlCannabinoid receptor 1 (brain) CNRlCollagen, type XVIII, alpha 1 COLl 8AlCollagen, type I, alpha 1 COLlAlCollagen, type IV, alpha 3 (Goodpasture antigen) COL4A3COMM domain containing 5 C0MMD5Catechol-O-methyltransferase COMTCoatomer protein complex, subunit beta 2 (beta prime) COPB2COP9 constitutive photomorphogenic homolog subunit 5

COPS5(Arabidopsis)Cytoplasmic polyadenylation element binding protein 3 CPEB3Cysteine-rich secretory protein 3 CRISP3V-crk sarcoma virus CTlO oncogene homolog (avian) CRKV-crk sarcoma virus CTlO oncogene homolog (avian)-like CRKLColony stimulating factor 1 receptor, formerly McDonough

CSFlRfeline sarcoma viral (v-fms) oncogene homologColony stimulating factor 2 (granulocyte-macrophage) CSF2Colony stimulating factor 3 receptor (granulocyte) CSF3RC-src tyrosine kinase CSKCystatin B (stefin B) CSTBConnective tissue growth factor CTGFCollagen triple helix repeat containing 1 CTHRClCatenin (cadherin-associated protein), alpha 1, 102kDa CTNNAlCatenin (cadherin-associated protein), beta 1, 88kDa CTNNB 1Cathepsin B CTSBCathepsin L l CTSLlCortactin CTTNCullin 2 CUL2Chemokine (C-X-C motif) ligand 14 CXCL 14Chemokine (C-X-C motif) ligand 9 CXCL9Chromosome X open reading frame 4 1 CXorf41Cytochrome b5 type A (microsomal) CYB5ACytoplasmic FMRl interacting protein 1 CYFIPlCytochrome P450, family 27, subfamily A, polypeptide 1 CYP27A1Cytochrome P450, family 2, subfamily C, polypeptide 9 CYP2C9Cytochrome P450, family 3, subfamily A, polypeptide 5 CYP3A5Disabled homolog 2, mitogen-responsive phosphoprotein

DAB2(Drosophila)Death associated protein 3 DAP3Death-associated protein kinase 1 DAPKlDeleted in colorectal carcinoma DCCDodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-

DCICoenzyme A isomerase)Decorin DCNDynactin 2 (p50) DCTN2Damage-specific DNA binding protein 2, 48kDa DDB2Dopa decarboxylase (aromatic L-amino acid decarboxylase) DDCDevelopment and differentiation enhancing factor 1 DDEFlDNA-damage-inducible transcript 3 DDIT3

Gene Name SymbolDEAD (Asp-Glu- Ala-Asp) box polypeptide 6 DDX62,4-dienoyl CoA reductase 2, peroxisomal DECR2DEK oncogene (DNA binding) DEKDENN/MADD domain containing 3 DENND3DEP domain containing 1B DEPDClBDEP domain containing 6 DEPDC6Diacylglycerol kinase, alpha 8OkDa DGKADEAH (Asp-Glu-Ala-His) box polypeptide 9 DHX9Deiodinase, iodothyronine, type II DIO2DIRAS family, GTP-binding RAS-like 3 DIRAS3Dyskeratosis congenita 1, dyskerin DKCl

DKFZP564O0823 protein DKFZP564O0823

Discs, large homolog 3 (neuroendocrine-dlg, Drosophila) DLG3Discs, large (Drosophila) homolog-associated protein 1 DLGAPlDeleted in malignant brain tumors 1 DMBTlDedicator of cytokinesis 5 D0CK5Desmoplakin DSPE2F transcription factor 1 E2F1E2F transcription factor 2 E2F2E2F transcription factor 3 E2F3E2F transcription factor 4, p 107/p 130-binding E2F4Endothelial differentiation, lysophosphatidic acid G-protein-

EDG7coupled receptor, 7Endothelin receptor type B EDNRBEukaryotic translation elongation factor 1 alpha 1 EEFlAlEmbryonal Fyn-associated substrate EFSEpidermal growth factor (beta-urogastrone) EGFEpidermal growth factor receptor (erythroblastic leukemia

EGFRviral (v-erb-b) oncogene homolog, avian)Early growth response 2 (Krox-20 homolog, Drosophila) EGR2Early growth response 3 EGR3Euchromatic histone-lysine N-methyltransferase 1 EHMTlEuchromatic histone-lysine N-methyltransferase 2 EHMT2Eukaryotic translation initiation factor 2-alpha kinase 2 EIF2AK2Eukaryotic translation initiation factor 3, subunit H EIF3HELKl , member of ETS oncogene family ELKlELK3, ETS-domain protein (SRF accessory protein 2) ELK3Elongation factor RNA polymerase II ELLElongation factor RNA polymerase II-like 3 ELL3Epithelial membrane protein 2 EMP2Ectonucleotide pyrophosphatase/phosphodiesterase 2

ENPP2(autotaxin)Enhancer of yellow 2 homolog (Drosophila) ENY2EPH receptor A l EPHAlEPH receptor B4 EPHB4Epsin 1 EPNlErythropoietin EPOEpidermal growth factor receptor pathway substrate 15 EPS 15

Epidermal growth factor receptor pathway substrate 8 EPS 8

Gene Name SymbolV-erb-b2 erythroblastic leukemia viral oncogene homolog 2,

ERBB2neuro/glioblastoma derived oncogene homolog (avian)V-erb-b2 erythroblastic leukemia viral oncogene homolog 3

ERBB3(avian)V-erb-a erythroblastic leukemia viral oncogene homolog 4

ERBB4(avian)Excision repair cross-complementing rodent repairdeficiency, complementation group 1 (includes overlapping ERCClantisense sequence)Excision repair cross-complementing rodent repairdeficiency, complementation group 2 (xeroderma ERCC2pigmentosum D)Excision repair cross-complementing rodent repairdeficiency, complementation group 3 (xeroderma ERCC3pigmentosum group B complementing)Excision repair cross-complementing rodent repair

ERCC4deficiency, complementation group 4Excision repair cross-complementing rodent repairdeficiency, complementation group 5 (xeroderma

ERCC5pigmentosum, complementation group G (Cockaynesyndrome))Excision repair cross-complementing rodent repair

ERCC6deficiency, complementation group 6V-ets erythroblastosis virus E26 oncogene homolog (avian) ERGEndoplasmic reticulum to nucleus signaling 2 ERN2Estrogen receptor 1 ESRlEstrogen receptor 2 (ER beta) ESR2V-ets erythroblastosis virus E26 oncogene homolog 1

ETS l(avian)V-ets erythroblastosis virus E26 oncogene homolog 2

ETS2(avian)Ets variant gene 1 ETVlEts variant gene 4 (ElA enhancer binding protein, ElAF) ETV4Ets variant gene 6 (TEL oncogene) ETV6Even-skipped homeobox 1 EVXlExocyst complex component 2 EXOC2Exostoses (multiple) 1 EXTlExostoses (multiple) 2 EXT2Enhancer of zeste homolog 2 (Drosophila) EZH2Ezrin EZRCoagulation factor II (thrombin) receptor F2RCoagulation factor V (proaccelerin, labile factor) F5Family with sequence similarity 114, member A l FAMl 14AlFamily with sequence similarity 13, member C l FAM 13ClFamily with sequence similarity 49, member B FAM49BFamily with sequence similarity 84, member B FAM84BFamily with sequence similarity 8, member A l FAM8A1Fanconi anemia, complementation group A FANCAFanconi anemia, complementation group G FANCGFas (TNF receptor superfamily, member 6) FASFas ligand (TNF superfamily, member 6) FASLG

Gene Name SymbolFatty acid synthase FASNFibulin 1 FBLNlF-box protein 32 FBXO32F-box and WD repeat domain containing 11 FBXWI lFames yl diphosphate synthase (farnesyl pyrophosphatesynthetase, dimethylallyltranstransferase, FDPSgeranyltranstransferase)Fer (fps/fes related) tyrosine kinase (phosphoprotein

FERNCP94)Feline sarcoma oncogene FESFEV (ETS oncogene family) FEVFibroblast growth factor 12 FGF 12

Fibroblast growth factor 3 (murine mammary tumor virusFGF3

integration site (v-int-2) oncogene homolog)Fibroblast growth factor 5 FGF5Fibroblast growth factor 8 (androgen-induced) FGF8Fibroblast growth factor 9 (glia-activating factor) FGF9Fibroblast growth factor receptor 1 (fms-related tyrosine

FGFRlkinase 2, Pfeiffer syndrome)Fibroblast growth factor receptor 2 (bacteria-expressedkinase, keratinocyte growth factor receptor, craniofacial

FGFR2dysostosis 1, Crouzon syndrome, Pfeiffer syndrome,Jackson-Weiss syndrome)Fibroblast growth factor receptor 4 FGFR4Fragile histidine triad gene FHITFolliculin FLCNFriend leukemia virus integration 1 FLIlHypothetical protein FLJ90709 FLJ90709Fms-related tyrosine kinase 1 (vascular endothelial growth

FLTlfactor/vascular permeability factor receptor)Fms-related tyrosine kinase 4 FLT4Flavin containing monooxygenase 5 FM05Fibromodulin FMODFolate hydrolase (prostate-specific membrane antigen) 1 FOLHlFolate receptor 1 (adult) FOLRlV-fos FBJ murine osteosarcoma viral oncogene homolog FOSFK506 binding protein 12-rapamycin associated protein 1 FRAPlFrizzled-related protein FRZBFYN oncogene related to SRC, FGR, YES FYNFrizzled homolog 7 (Drosophila) FZD7Gamma-aminobutyric acid (GABA) A receptor, gamma 2 GABRG2Growth arrest and DNA-damage-inducible, alpha GADD45AG protein beta subunit-like GBLGastrulation brain homeobox 2 GBX2Ganglioside-induced differentiation-associated protein 1 GDAPlGrowth differentiation factor 15 GDF 15

Glioma-associated oncogene homolog 1 (zinc finger protein) GLIlGlutaredoxin 2 GLRX2GPI anchored molecule like protein GMLGeminin, DNA replication inhibitor GMNNGuanine nucleotide binding protein (G protein), alpha 15 GNA 15

Gene Name SymbolGNAS complex locus GNASGuanine nucleotide binding protein (G protein), beta

GNBlpolypeptide 1Glucosamine (UDP-N-acetyl)-2-epimerase/N-

GNEacetylmannosamine kinaseN-acetylglucosamine- 1-phosphate transferase, alpha and

GNPTABbeta subunitsGolgi membrane protein 1 GOLMlGolgi-localized protein GOLSYNG protein-coupled receptor 137B GPR137BGrowth factor receptor-bound protein 2 GRB2Growth factor receptor-bound protein 7 GRB7Gremlin 2, cysteine knot superfamily, homolog (Xenopus

GREM2laevis)Gastrin-releasing peptide receptor GRPRGlycogen synthase kinase 3 alpha GSK3AGlutathione S-transferase pi GSTPlGlucuronidase, beta GUSBH l histone family, member X HlFXHeparin-binding EGF-like growth factor HBEGFHCCA2 protein HCCA2Host cell factor C 1 (VP 16-accessory protein) HCFClHemopoietic cell kinase HCKHistone deacetylase 1 HDAClHistone deacetylase 7A HDAC7AHepatoma-derived growth factor (high-mobility group

HDGFprotein 1-like)HECT, C2 and WW domain containing E3 ubiquitin protein

HECW2ligase 2Hypoxia-inducible factor 1, alpha subunit (basic helix-loop-

HIFlAhelix transcription factor)Hydroxymethylbilane synthase HMBS3-hydroxy-3-methylglutaryl-Coenzyme A reductase HMGCRHyaluronan-mediated motility receptor (RHAMM) HMMRHook homolog 1 (Drosophila) HOOKlHomeobox A9 H0XA9Homeobox C4 H0XC4Hepsin (transmembrane protease, serine 1) HPNHypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan

HPRTlsyndrome)V-Ha-ras Harvey rat sarcoma viral oncogene homolog HRASHydroxysteroid (17-beta) dehydrogenase 4 HSD17B4Hydroxysteroid (17-beta) dehydrogenase 6 homolog

HSD17B6(mouse)Heat shock transcription factor 4 HSF4Heat shock 27kDa protein 1 HSPBlIntercellular adhesion molecule 1 (CD54), human rhinovirus

ICAMlreceptorImmediate early response 3 IER3Interferon, gamma IFNGInterferon gamma receptor 1 IFNGRl

Gene Name SymbolInsulin-like growth factor 1 (somatomedin C) IGFlInsulin-like growth factor 1 receptor IGFlRInsulin-like growth factor 2 receptor IGF2RInsulin-like growth factor binding protein 1 IGFBPlInsulin-like growth factor binding protein 2, 36kDa IGFBP2Insulin-like growth factor binding protein 3 IGFBP3Insulin-like growth factor binding protein 6 IGFBP6IKAROS family zinc finger 1 (Ikaros) IKZFlInterleukin 11 ILI lInterleukin 12A (natural killer cell stimulatory factor 1,

IL12Acytotoxic lymphocyte maturation factor 1, p35)Interleukin 12B (natural killer cell stimulatory factor 2,

IL12Bcytotoxic lymphocyte maturation factor 2, p40)Interleukin 13 IL 13

Interleukin 1, beta ILlBInterleukin 2 IL2Interleukin 3 (colony-stimulating factor, multiple) IL3Interleukin 4 IL4Interleukin 6 (interferon, beta 2) IL6Interleukin 6 receptor IL6RInterleukin 8 IL8Integrin- linked kinase ILKInner membrane protein, mitochondrial (mitofilin) IMMTInhibin, alpha INHAInhibin, beta A INHBAInterferon regulatory factor 1 IRFlInsulin receptor substrate 2 IRS2ISL LIM homeobox 1 ISLlIntegrin, alpha V (vitronectin receptor, alpha polypeptide,

ITGAVantigen CD5 1)Integrin, beta 1 (fibronectin receptor, beta polypeptide,

ITGBlantigen CD29 includes MDF2, MSK 12)Integrin, beta 3 (platelet glycoprotein Ilia, antigen CD61) ITGB3Integrin, beta 4 ITGB4Inositol 1,4,5-trisphosphate 3-kinase A ITPKAInositol 1,4,5-triphosphate receptor, type 1 ITPRlIsovaleryl Coenzyme A dehydrogenase IVDJanus kinase 2 (a protein tyrosine kinase) JAK2Jumonji, AT rich interactive domain IA JARIDlAJumonji domain containing 2B JMJD2BJun oncogene JUNJun B proto-oncogene JUNBJun D proto-oncogene JUNDPotassium channel regulator KCNRGKinase insert domain receptor (a type III receptor tyrosine

KDRkinase)KH domain containing, RNA binding, signal transduction

KHDRBS3associated 3KIAAO 196 KIAAO 196KIAA0922 KIAA0922KIAA 13 24 KIAA 1324

Gene Name SymbolKinesin family member C2 KIFC2V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene

KIThomologKruppel-like factor 6 KLF6Kelch domain containing 4 KLHDC4Kallikrein-related peptidase 2 KLK2Kallikrein-related peptidase 3 KLK3Kallikrein-related peptidase 4 KLK4Karyopherin (importin) beta 1 KPNBlKeratin 15 KRT 15

Keratin 5 (epidermolysis bullosa simplex, Dowling-KRT5

Meara/Kobner/Weber-Cockayne types)L l cell adhesion molecule LlCAMLymphocyte- specific protein tyrosine kinase LCKLipocalin 2 LCN2Leprecan-like 1 LEPRELlLeucine-rich repeat-containing G protein-coupled receptor 4 LGR4Ligase I, DNA, ATP-dependent LIG lLigase III, DNA, ATP-dependent LIG3LIM domain only 1 (rhombotin 1) LMOlLIM domain only 2 (rhombotin-like 1) LM02Poly (ADP-ribose) polymerase family, member 1 LOC649459Lactotransferrin LOC728320Hypothetical protein BC008326 LOC89944Lysyl oxidase LOXLeucine rich repeat containing 2 LRRC2Limbic system-associated membrane protein LSAMPLatent transforming growth factor beta binding protein 2 LTBP2MaI, T-cell differentiation protein-like MALLMucosa associated lymphoid tissue lymphoma translocation

MALTlgene 1Monoamine oxidase B MAOBMitogen-activated protein kinase kinase 6 MAP2K6Mitogen-activated protein kinase kinase kinase 8 MAP3K8Mitogen-activated protein kinase 1 MAPKlMitogen-activated protein kinase 10 MAPKlOMitogen-activated protein kinase 14 MAPK 14

MARCKS-like 1 MARCKSLlMARVEL domain containing 3 MARVELD3MAS 1oncogene MASlMegakaryocyte-associated tyrosine kinase MATKMethyl-CpG binding domain protein 2 MBD2Melanoma cell adhesion molecule MCAMMutated in colorectal cancers MCCMCF.2 cell line derived transforming sequence MCF2Myeloid cell leukemia sequence 1 (BCL2-related) MCLlMinichromosome maintenance complex component 7 MCM7Microcephalin 1 MCPHlMdm4, transformed 3T3 cell double minute 4, p53 binding

MDM4protein (mouse)Mediator complex subunit 30 MED30

Gene Name SymbolMyocyte enhancer factor 2C MEF2CMeis homeobox 2 MEIS2Multiple endocrine neoplasia I MENlMet proto-oncogene (hepatocyte growth factor receptor) METMethyltransferase 10 domain containing METHODHypothetical protein MGC 15523 MGC 15523Antigen identified by monoclonal antibody Ki-67 MKI67Myeloid leukemia factor 1 MLFlMyeloid leukemia factor 2 MLF2MutL homolog 1, colon cancer, nonpolyposis type 2 (E.

MLHlcoli)Myeloid/lymphoid or mixed-lineage leukemia (trithorax

MLLT3homolog, Drosophila); translocated to, 3Myeloid/lymphoid or mixed-lineage leukemia (trithorax

MLLT4homolog, Drosophila); translocated to, 4Myeloid/lymphoid or mixed-lineage leukemia (trithorax

MLLT6homolog, Drosophila); translocated to, 6Matrix metallopeptidase 1 (interstitial collagenase) MMPlMatrix metallopeptidase 10 (stromelysin 2) MMPlOMatrix metallopeptidase 14 (membrane-inserted) MMP 14

Matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase,MMP2

72kDa type IV collagenase)Matrix metallopeptidase 3 (stromelysin 1, progelatinase) MMP3Matrix metallopeptidase 7 (matrilysin, uterine) MMP7Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase,

MMP992kDa type IV collagenase)V-mos Moloney murine sarcoma viral oncogene homolog MOSMembrane protein, palmitoylated 7 (MAGUK p55

MPP7subfamily member 7)Mitochondrial ribosomal protein L l3 MRPL 13

MutS homolog 2, colon cancer, nonpolyposis type 1 (E.MSH2

coli)MutS homolog 3 (E. coli) MSH3MutS homolog 6 (E. coli) MSH6Microseminoprotein, beta- MSMBMacrophage scavenger receptor 1 MSRlMacrophage stimulating 1receptor (c-met-related tyrosine

MSTlRkinase)Metastasis associated 1 MTAl5,10-methylenetetrahydrofolate reductase (NADPH) MTHFRMyotrophin MTPN5-methyltetrahydrofolate-homocysteine methyltransferase MTRMetastasis suppressor 1 MTSSlMucin 1, cell surface associated MUClMAX dimerization protein 1 MXDlMAX interactor 1 MXIlV-myb myeloblastosis viral oncogene homolog (avian) MYBV-myb myeloblastosis viral oncogene homolog (avian)-like

MYBL22Myosin binding protein C, slow type MYBPC 1V-myc myelocytomatosis viral oncogene homolog (avian) MYC

Gene Name SymbolV-myc myelocytomatosis viral related oncogene,

MYCNneuroblastoma derived (avian)Myosin, heavy chain 11, smooth muscle MYHI lMyosin, light chain 9, regulatory MYL9Myosin, light chain kinase MYLKN-acetyltransferase 2 (arylamine N-acetyltransferase) NAT2Neuroblastoma, suppression of tumorigenicity 1 NBLlNibrin NBNNon-SMC condensin II complex, subunit D3 NCAPD3N-myc downstream regulated gene 1 NDRGlNADH dehydrogenase (ubiquinone) 1beta subcomplex, 9,

NDUFB922kDaNeurofilament, heavy polypeptide 20OkDa NEFHNeogenin homolog 1 (chicken) NEOlNeuropilin (NRP) and tolloid (TLL)-like 2 NETO2Neurofibromin 1 (neurofibromatosis, von Recklinghausendisease, Watson disease)

NFl

Nuclear factor of kappa light polypeptide gene enhancer inB-cells 1 (pi 05)

NFKBl

Nuclear factor of kappa light polypeptide gene enhancer inB-cells 2 (p49/p 100)

NFKB2

Nuclear factor of kappa light polypeptide gene enhancer inNFKBIA

B-cells inhibitor, alphaNitric oxide synthase 3 (endothelial cell) NOS3Notch homolog 1, translocation-associated (Drosophila) NOTCHlNotch homolog 2 (Drosophila) N0TCH2Notch homolog 4 (Drosophila) N0TCH4Nephroblastoma overexpressed gene NOVNADPH oxidase 4 N0X4Aminopeptidase-like 1 NPEPLlNAD(P)H dehydrogenase, quinone 1 NQOlNuclear receptor subfamily 4, group A, member 1 NR4A1Neuroblastoma RAS viral (v-ras) oncogene homolog NRASNeuropilin 1 NRPlNeurotrophic tyrosine kinase, receptor, type 1 NTRKlNeurotrophic tyrosine kinase, receptor, type 2 NTRK2Neurotrophic tyrosine kinase, receptor, type 3 NTRK3Nuclear mitotic apparatus protein 1 NUMAlNucleoporin 98kDa NUP98Ornithine decarboxylase antizyme 2 0AZ2Oxysterol binding protein-like 9 OSBPL9P antigen family, member 4 (prostate associated) PAGE4PAP associated domain containing 1 PAPDlPar-3 partitioning defective 3 homolog (C. elegans) PARD3PAS domain containing serine/threonine kinase PASKPre-B-cell leukemia homeobox 1 PBXlProliferating cell nuclear antigen PCNAPCTAIRE protein kinase 1 PCTKlPlatelet-derived growth factor alpha polypeptide PDGFAPlatelet-derived growth factor receptor, alpha polypeptide PDGFRAPlatelet-derived growth factor receptor, beta polypeptide PDGFRB

Gene Name SymbolProtein disulfide isomerase family A, member 5 PDIA5PDZ and LIM domain 5 PDLIM5Phosphatidylethanolamine-binding protein 4 PEBP4Phosphatidylethanolamine N-methyltransferase PEMTPlacental growth factor, vascular endothelial growth factor-

PGFrelated proteinPhosphoglycerate kinase 1 PGKlProgesterone receptor PGRPhosphatase and actin regulator 2 PHACTR2PHD finger protein 20-like 1 PHF20L1PHD finger protein 8 PHF8Phytanoyl-CoA 2-hydroxylase interacting protein-like PHYHIPLProtein inhibitor of activated STAT, 2 PIAS2Phosphoinositide-3-kinase, catalytic, alpha polypeptide PIK3CAPhosphoinositide-3-kinase, catalytic, delta polypeptide PIK3CDPolycystic kidney and hepatic disease 1 (autosomal

PKHDlLlrecessive)-like 1Phospholipase A2, group HA (platelets, synovial fluid) PLA2G2APhospholipase A2, group VII (platelet-activating factor

PLA2G7acetylhydrolase, plasma)Pleomorphic adenoma gene 1 PLAGlPlasminogen activator, tissue PLATPlasminogen activator, urokinase receptor PLAURPlasminogen PLGPlexin domain containing 1 PLXDC 1Promyelocyte leukemia PMLPMSl postmeiotic segregation increased 1 (S. cerevisiae) PMSlPolymerase (RNA) I polypeptide C, 3OkDa POLRlCPeriostin, osteoblast specific factor POSTNPOU class 2 homeobox 1 P0U2F1Peroxisome proliferator-activated receptor delta PPARDPeroxisome proliferator-activated receptor gamma PPARGProtein phosphatase 2 (formerly 2A), regulatory subunit A,

PPP2R1Bbeta isoformPapillary renal cell carcinoma (translocation-associated) PRCCPeroxisomal proliferator-activated receptor A interacting

PRIC285complex 285Protein kinase, cAMP-dependent, regulatory, type I, alpha

PRKARlA(tissue specific extinguisher 1)

Protease, serine, 8 PRSS8Prostate stem cell antigen PSCAProteasome (prosome, macropain) 26S subunit, non-

PSMDlATPase, 1Patched homolog 1 (Drosophila) PTCHlPatched homolog 2 (Drosophila) PTCH2Prostaglandin E receptor 3 (subtype EP3) PTGER3Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H

PTGS lsynthase and cyclooxygenase)Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H

PTGS2synthase and cyclooxygenase)Parathyroid hormone-like hormone PTHLH

Gene Name SymbolPTK2 protein tyrosine kinase 2 PTK2PTK7 protein tyrosine kinase 7 PTK7Pleiotrophin (heparin binding growth factor 8, neurite

PTNgrowth-promoting factor 1)Protein tyrosine phosphatase type IVA, member 3 PTP4A3Protein tyrosine phosphatase-like (proline instead of

PTPLBcatalytic arginine), member bProtein tyrosine phosphatase, receptor type, F PTPRFProtein tyrosine phosphatase, receptor type, G PTPRGProtein tyrosine phosphatase, receptor type, H PTPRHProtein tyrosine phosphatase, receptor type, N polypeptide 2 PTPRN2PoIy-U binding splicing factor 60KDa PUF60Purine-rich element binding protein A PURAPaxillin PXNPyrroline-5-carboxylate reductase 1 PYCRlPyrroline-5-carboxylate reductase-like PYCRLGlutaminyl-tRNA synthetase QARSRAB32, member RAS oncogene family RAB32RAB8A, member RAS oncogene family RAB8ARabaptin, RAB GTPase binding effector protein 2 RABEP2RAD21 homolog (S. pombe) RAD21RAD23 homolog A (S. cerevisiae) RAD23ARAD50 homolog (S. cerevisiae) RAD50RAD54 homolog B (S. cerevisiae) RAD54BV-raf- 1 murine leukemia viral oncogene homolog 1 RAFlV-ral simian leukemia viral oncogene homolog B (ras

RALBrelated; GTP binding protein)RAPl, GTP-GDP dissociation stimulator 1 RAPlGDS lRAP2A, member of RAS oncogene family RAP2ARetinoic acid receptor, alpha RARARAS p2 1protein activator (GTPase activating protein) 1 RASAlRetinoblastoma 1 (including osteosarcoma) RBlRetinoblastoma binding protein 6 RBBP6Retinoblastoma-like 2 (pi 30) RBL2Retinol dehydrogenase 11 (all-trans/9-cis/l 1-cis) RDHI lRecQ protein-like (DNA helicase Q 1-like) RECQLRecQ protein-like 4 RECQL4V-rel reticuloendotheliosis viral oncogene homolog (avian) RELV-rel reticuloendotheliosis viral oncogene homolog A,nuclear factor of kappa light polypeptide gene enhancer in RELAB-cells 3, p65 (avian)Ret proto-oncogene RETRas homolog gene family, member A RHOARas homolog gene family, member H RHOHReceptor (TNFRSF)-interacting serine-threonine kinase 1 RIPKlRelaxin 1 RLNlRing finger protein 139 RNF 139Ring finger protein 185 RNF 185V-ros UR2 sarcoma virus oncogene homolog 1 (avian) ROS lReplication protein Al, 7OkDa RPAlRas-related GTP binding C RRAGC

Gene Name SymbolRelated RAS viral (r-ras) oncogene homolog RRASRhabdoid tumor deletion region gene 1 RTDRlS 100 calcium binding protein A4 S 100A4Sterile alpha motif domain containing 12 SAMD 12Stearoyl-CoA desaturase 5 SCD5Sodium channel and clathrin linker 1 SCLTlSodium channel, nonvoltage-gated 1 alpha SCNNlAScribbled homolog (Drosophila) SCRIBSyndecan 2 SDC2Succinate dehydrogenase complex, subunit B, iron sulfur

SDHBdp)Succinate dehydrogenase complex, subunit C, integral

SDHCmembrane protein, 15kDaSEC14-like 1 (S. cerevisiae) SEC 14LlSema domain, immunoglobulin domain (Ig), short basic

SEMA3Fdomain, secreted, (semaphorin) 3FSerpin peptidase inhibitor, clade B (ovalbumin), member 5 SERPINB5Serpin peptidase inhibitor, clade I (neuroserpin), member 1 SERPINIlSplicing factor 1 SFlSecreted frizzled-related protein 4 SFRP4SH3-domain binding protein 2 SH3BP2SH3 domain containing ring finger 2 SH3RF2Sonic hedgehog homolog (Drosophila) SHHSeven in absentia homolog 1 (Drosophila) SIAHlV-ski sarcoma viral oncogene homolog (avian) SKISKI-like oncogene SKILSolute carrier family 14 (urea transporter), member 1 (Kidd

SLC 14Alblood group)Solute carrier family 20 (phosphate transporter), member 1 SLC20A1Solute carrier family 22 (extraneuronal monoamine

SLC22A3transporter), member 3Solute carrier family 25, member 42 SLC25A42Solute carrier family 44, member 1 SLC44A1Solute carrier family 45, member 3 SLC45A3SMAD family member 4 SMAD4SWI/SNF related, matrix associated, actin dependent

SMARCB 1regulator of chromatin, subfamily b, member 1SWI/SNF related, matrix associated, actin dependent

SMARCC 1regulator of chromatin, subfamily c, member 1Sphingomyelin phosphodiesterase, acid-like 3B SMPDL3BSmall nuclear ribonucleoprotein polypeptide E SNRPESyntrophin, beta 1 (dystrophin-associated protein Al,

SNTBl59kDa, basic component 1)

Syntrophin, beta 2 (dystrophin-associated protein Al,SNTB2

59kDa, basic component 2)Syntrophin, gamma 1 SNTGlSuppressor of cytokine signaling 7 SOCS7Superoxide dismutase 1, soluble (amyotrophic lateral

SODlsclerosis 1 (adult))Secreted protein, acidic, cysteine-rich (osteonectin) SPARCSAM pointed domain containing ets transcription factor SPDEF

Gene Name SymbolSpleen focus forming virus (SFFV) proviral integration

SPIloncogene spi 1Secreted phosphoprotein 1 (osteopontin, bone sialoprotein I,

SPPlearly T-lymphocyte activation 1)

Squalene epoxidase SQLESulfide quinone reductase-like (yeast) SQRDLV-src sarcoma (Schmidt-Ruppin A-2) viral oncogene

SRChomolog (avian)Steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5

SRD5A2alpha- steroid delta 4-dehydrogenase alpha 2)ST3 beta-galactoside alpha-2,3-sialyltransferase 1 ST3GAL1ST3 beta-galactoside alpha-2,3-sialyltransferase 5 ST3GAL5ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 ST6GAL1Suppression of tumorigenicity 7 ST7Signal transducer and activator of transcription 1, 9IkDa STATlSignal transducer and activator of transcription 3 (acute-

STAT3phase response factor)Signal transducer and activator of transcription 5B STAT5BSix transmembrane epithelial antigen of the prostate 2 STEAP2Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing

STIPlprotein)Serine/threonine kinase 11 STKI lSpleen tyrosine kinase SYKSynapsin I SYNlSynapsin III SYN3Tumor-associated calcium signal transducer 1 TACSTDlTATA box binding protein (TBP)-associated factor, RNA

TAFlCpolymerase I, C, 11OkDaTAF2 RNA polymerase II, TATA box binding protein

TAF2(TBP)-associated factor, 15OkDaT-cell acute lymphocytic leukemia 1 TALITax 1 (human T-cell leukemia virus type I) binding protein 1 TAXlBPlTATA box binding protein TBPTranscription factor 7-like 2 (T-cell specific, HMG-box) TCF7L2TEK tyrosine kinase, endothelial (venous malformations,

TEKmultiple cutaneous and mucosal)Telomerase reverse transcriptase TERTTranscription factor AP-2 gamma (activating enhancer

TFAP2Cbinding protein 2 gamma)Transcription factor Dp- 1 TFDPlTranscription factor binding to IGHM enhancer 3 TFE3Trefoil factor 1 TFFlTRK-fused gene TFGTransferrin receptor (p90, CD7 1) TFRCTransforming growth factor, alpha TGFATransforming growth factor, beta 1 TGFBlTransforming growth factor, beta 2 TGFB2Transforming growth factor, beta 3 TGFB3Transforming growth factor, beta-induced, 68kDa TGFBITransforming growth factor, beta receptor I (activin A

TGFBRlreceptor type II-like kinase, 53kDa)

Gene Name Symbol

Transforming growth factor, beta receptor II (70/8OkDa) TGFBR2Transforming growth factor, beta receptor III TGFBR3Transglutaminase 2 (C polypeptide, protein-glutamine-

TGM2gamma-glutamyltransferase)Thrombospondin 1 THBSlThrombospondin 2 THBS2Thrombopoietin (myeloproliferative leukemia virusoncogene ligand, megakaryocyte growth and development THPOfactor)T-cell lymphoma invasion and metastasis 1 TIAMlTIMP metallopeptidase inhibitor 2 TIMP2Thymidine kinase 1, soluble TKlTransmembrane protein with EGF-like and two follistatin-

TMEFF2like domains 2Transmembrane protein 134 TMEM 134Transmembrane protein 45B TMEM45BTransmembrane protein 65 TMEM65Transmembrane protein 7 1 TMEM7 1Transmembrane protease, serine 2 TMPRSS2Tumor necrosis factor receptor superfamily, member 10a TNFRSFlOATumor necrosis factor receptor superfamily, member 10b TNFRSFlOBTumor necrosis factor receptor superfamily, member 1Ia,

TNFRSFl IANFKB activatorTumor necrosis factor receptor superfamily, member 1Ib

TNFRSFI lB(osteoprotegerin)Tumor necrosis factor receptor superfamily, member IA TNFRSFlATumor necrosis factor (ligand) superfamily, member 10 TNFSFlOTumor necrosis factor (ligand) superfamily, member 8 TNFSF8Topoisomerase (DNA) I TOPlTopoisomerase (DNA) II alpha 17OkDa TOP2ATumor protein p53 (Li-Fraumeni syndrome) TP53Tumor protein p53 inducible protein 11 TP53I1 1Tumor protein p73 TP73Translocated promoter region (to activated MET oncogene) TPRTPX2, microtubule-associated, homolog (Xenopus laevis) TPX2Tripartite motif-containing 38 TRIM38TRNA methyltransferase 12 homolog (S. cerevisiae) TRMT 12Transient receptor potential cation channel, subfamily M,

TRPM8member 8Trichorhinophalangeal syndrome I TRPSlTuberous sclerosis 1 TSClTuberous sclerosis 2 TSC2Tetraspanin 13 TSPAN 13

Tetraspanin 14 TSPAN 14

Tissue specific transplantation antigen P35B TSTA3Tetratricopeptide repeat domain 29 TTC29Thymidylate synthetase TYMSTYRO3 protein tyrosine kinase TYR03Ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog,

UBE2J2yeast)

Gene Name SymbolUBX domain containing 3 UBXD3Vesicle-associated membrane protein 2 (synaptobrevin 2) VAMP2Vav 1 guanine nucleotide exchange factor VAVlVav 2 guanine nucleotide exchange factor VAV2Versican VCANVascular endothelial growth factor A VEGFAVestigial like 3 (Drosophila) VGLL3Wiskott-Aldrich syndrome (eczema-thrombocytopenia) WASWD repeat domain 67 WDR67WEEl homolog (S. pombe) WEElWNTl inducible signaling pathway protein 1 WISPlWingless-type MMTV integration site family, member K)B WNTlOBWingless-type MMTV integration site family member 2 WNT2Wingless-type MMTV integration site family, member 2B WNT2BWingless-type MMTV integration site family, member 5A WNT5AWingless-type MMTV integration site family, member 8B WNT8BWerner syndrome WRNWilms tumor 1 WTlXanthine dehydrogenase XDHXeroderma pigmentosum, complementation group A XPAXeroderma pigmentosum, complementation group C XPCX-ray repair complementing defective repair in Chinese

XRCClhamster cells 1X-ray repair complementing defective repair in Chinese

XRCC4hamster cells 4X-ray repair complementing defective repair in Chinesehamster cells 5 (double-strand-break rejoining; Ku XRCC5autoantigen, 8OkDa)X-ray repair complementing defective repair in Chinese

XRCC6hamster cells 6 (Ku autoantigen, 7OkDa)V-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 YESlYipl domain family, member 1 YIPFlTyrosine 3-monooxygenase/tryptophan 5-monooxygenase

YWHABactivation protein, beta polypeptideZinc finger protein 36, C3H type, homolog (mouse) ZFP36Zinc finger protein 3 13 ZNF3 13

Zinc finger protein 34 ZNF34Zinc finger protein 5 11 ZNF5 11Zinc finger protein 7 ZNF7

Table 7 . RNA transcripts used to derive metagene values for 18-RNA metagene depicted in

Figure 3 . The 6-RNA metagene is a subset of the sequences listed in Table 7, also depicted in

Figure 3 . 18-RNA metagene scores were scaled and normalized to generate 'POP' scores

depicted in Figure 4 . Weighting factors were from the linear regression coefficient values;

positive and negative values indicated transcripts correlated to increased expression in 'SYS' and

'NED' disease, respectively with intermediate expression values in the 'PSA' disease group.

SEQ ID No Weights1 -6.08

2 -5.71

3 -5.68

4 -5.39

5 -5.26

6 -4.84

7 -4.7

8 -4.68

9 -4.66

10 -4.55

1 1 -4.53

914 5.32

915 5.27

916 4.82

917 4.64

918 4.59

919 4.54

920 4.49

Table 8 . RNA transcripts used to derive metagene values for 20-RNA metagene depicted in

Figure 3 . Weighting factors were from the linear regression coefficient values; positive and

negative values indicated transcripts correlated to increased expression in 'SYS' and 'NED'

disease, respectively with intermediate expression values in the 'PSA' disease group.

SEQ ID No Weights1 -6.08

4 -5.39

6 -4.84

9 -4.66

14 -4.37

15 -4.32

16 -4.27

18 -4.2

19 -4.18

20 -4.1

2 1 -4.09

915 5.27

916 4.82

917 4.64

920 4.49

922 4.43

928 4.27

929 4.27

931 4.17

935 4.08

936 4.07

Table 9 . RNA transcripts used to derive K)-RNA metagene values, which were converted by

scaling and normalizing into 'POP' scores depicted in Figure 5 . RNA transcripts were identified

using Nearest Shrunken Centroids algorithm with leave- 1-out cross-validation to distinguish

'recurrent' (i.e., 'SYS') and 'non-recurrent' (i.e., 'PSA' and 'NED') disease from Table 3 RNA

transcripts. Weighting factors were from the test statistic values; positive and negative values

indicated transcripts correlated to increased expression in 'recurrent' and 'non-recurrent' disease,

respectively.

Seq ID Weights3 -5.48

36 -4.93

60 -5.72

63 -4.79

926 4.61

971 4.68

978 5.27

999 4.74

1014 4.86

1022 6.29

Table 10. RNA transcripts used to derive 4 1-RNA metagene values, which were converted by

scaling and normalizing into 'POP' scores depicted in Figure 6 . RNA transcripts were identified

using Nearest Shrunken Centroids algorithm with leave- 1-out cross-validation to distinguish

'recurrent' (i.e., 'SYS') and 'non-recurrent' (i.e., 'PSA' and 'NED') disease from Table 3 RNA

transcripts. Weighting factors were from the test statistic values; positive and negative values

indicated transcripts correlated to increased expression in 'recurrent' and 'non-recurrent' disease,

respectively.

SeqID Weights SeqID Weights

1 -4.1 947 4.44

2 -4.21 954 4.34

3 -5.48 971 4.68

32 -3.87 978 5.27

33 -3.75 999 4.74

36 -4.93 1004 4.5

46 -4.14 1014 4.86

60 -5.72 1022 6.29

63 -4.79 1023 4.08

66 -4.02 1032 3.49

69 -3.25 1080 3.97

88 -4.54 1093 4.02

100 -3.63 1101 3.55

241 -4.16 1164 3.54

265 -3.86 1248 3.56

334 -3.36 1304 3.14

437 -4.02 1311 3.66

920 4.36 1330 3.02

925 3.04 1402 3.45

934 3.65 1425 3.73

945 4.03

Although the invention has been described with reference to certain specific embodiments,

various modifications thereof will be apparent to those skilled in the art without departing from

the spirit and scope of the invention. All such modifications as would be apparent to one skilled

in the art are intended to be included within the scope of the following claims.

THE EMBODIMENTS OF THE INVENTION IN WHICH AN EXCLUSIVE PROPERTY

OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:

1. A system for expression-based assessment of prostate cancer recurrence risk, said system

comprising one or more polynucleotides, each of said polynucleotides capable of specifically

hybridizing to a RNA transcript of a gene selected from the group of genes set forth in Table 3

and/or Table 6 .

2 . The system of claim 1, wherein said one or more polynucleotides comprise one or more

polynucleotide probes for the detection of the respective transcript.

3 . The system of claim 1, wherein said one or more polynucleotides comprise one or more

primer pairs, each of said primer pairs capable of amplifying a portion of a sequence

corresponding to the respective transcript.

4 . The system of any one of claims 1, 2 and 3, wherein said transcript comprises a sequence

corresponding to one or more of the sequences set forth in SEQ ID NOs: 1-21 14.

5 . The system of any one of claims 1, 2 and 3, wherein said transcript comprises a sequence

corresponding to one or more of the sequences set forth ina SEQ ID NOs: 914-21 14.

6 . The system according to any one of claims 1 to 5, wherein said system comprises at least 5

polynucleotides.


polynucleotides.


polynucleotides.

9 . The system of claim 1, wherein each of said one or more polynucleotides comprises a

sequence corresponding to, or complementary to, one or more of the sequences set forth in Table

4 or a fragment thereof.

10. The system of claim 1, wherein each of said one or more polynucleotides comprises a

sequence corresponding to one or more nucleic acid molecules selected from the group

consisting of:

(a) a nucleic acid depicted in any one of SEQ ID NOs: 1-21 14;

(b) an RNA form of any one of the nucleic acids depicted in SEQ ID NOs: 1-21 14;

(c) a peptide nucleic acid form of any one of the nucleic acids depicted in SEQ ID NOs:

1-21 14;

(d) a nucleic acid comprising at least 20 consecutive bases of any of (a-c);

(e) a nucleic acid comprising at least 25 consecutive bases having at least 90% sequence

identity to any of (a-c); and

(f) a complement to any of (a-e).

11. The system of claim 1, wherein said transcript comprises one or more of the sequences as set

forth in SEQ ID NOs: 1, 4, 6, 9, 14-16, 18-21 915-917, 920, 922, 928, 929, 931, 935 and 936.

12 . The system of claim 1, wherein said transcript comprises one or more of the sequences as

set forth in SEQ ID NOs: 3, 36, 60, 63, 926, 971, 978, 999, 1014 and 1022.

13. The system of claim 1, wherein said transcript comprises one or more of the sequences as

set forth in SEQ ID NOs 1-3, 32, 33, 36, 46, 60, 63, 66, 69, 88, 100, 241, 265, 334, 437, 920,

925, 934, 945, 947, 954, 971, 978, 999, 1004, 1014, 1022, 1023, 1032, 1080, 1093, 1101, 1164,

1248, 1304, 131 1, 1330, 1402, 1425.

14 . Use of the system according to any one of claims 1, 2 and 4 to 11 for the preparation of a

nucleic acid array

15. A nucleic acid array for expression-based assessment of prostate cancer recurrence risk,

said array comprising at least ten probes immobilized on a solid support, each of said probes

being between about 15 and about 500 nucleotides in length, each of said probes being derived

from a sequence corresponding to, or complementary to, a transcript of a gene selected from the

group of genes set forth in Table 3, or a portion of said transcript.

16. The nucleic acid array according to claim 15, wherein each of said probes comprises a

sequence as set forth in any one of SEQ ID NOs: 1-21 14 or complement thereof.

17. A method for expression-based assessment of prostate cancer recurrence risk, said method

comprising: (a) determining the expression level of one or more transcripts of one or more genes

in a test sample obtained from said subject to provide an expression pattern profile, said one or

more genes selected from the group of genes set forth in Table 3, and (c) comparing said

expression pattern profile with a reference expression pattern profile.

18. The method of claim 17, wherein an increased relative level of expression of one or more

transcripts, a decreased relative level of expression of one or more transcripts, or a combination

thereof is used to classify a prostate cancer as recurrent.

19. The method of claim 17, wherein an increased relative level of expression of one or more

transcripts, a decreased relative level of expression of one or more transcripts, or a combination

thereof is used to classify a prostate cancer as non-recurrent.

20. The method of claim 17; wherein said transcripts comprise a sequence as set forth in any

one of SEQ ID NOs: 1-21 14 or complement thereof.

21. The method of claim 17, wherein said one or more transcripts comprise one or more

sequences as set forth in any one of SEQ ID NOs: 1, 4, 6, 9, 14-16, 18-21 915-917, 920, 922,

928, 929, 93 1, 935 and 936.

22. The method of claim 17, wherein said transcript comprises one or more of the sequences

as set forth in SEQ ID NOs: 3, 36, 60, 63, 926, 971, 978, 999, 1014 and 1022.

23. The method of claim 17, wherein said transcript comprises one or more of the sequences

as set forth in SEQ ID NOs 1-3, 32, 33, 36, 46, 60, 63, 66, 69, 88, 100, 241, 265, 334, 437, 920,

925, 934, 945, 947, 954, 971, 978, 999, 1004, 1014, 1022, 1023, 1032, 1080, 1093, 1101, 1164,

1248, 1304, 131 1, 1330, 1402, 1425.

24. The method of claim 17, wherein the expression level of the one or more target sequences is

determined by a method selected from the group consisting of RT-PCR, Northern blotting, ligase

chain reaction, array hybridization, and a combination thereof.

25. The method of any one of claims 17 to 24, further comprising measuring the expression

level of at least one control nucleic acid in the sample.

26. The method of any one of claims 17 to 25, wherein the sample is a fine needle aspirate

biopsy [FNAB], cytology smear, cytology pellet, or a bulk tissue preparation.

27. The method of any one of claims 17 to 26, wherein the sample is fresh-frozen or fixed.

28. The method of any one of claims 17 to 27, wherein measuring the expression level utilizes a

pattern recognition method.

29. The method of claim 28, wherein the pattern recognition method comprises a linear

combination of expression levels of the target sequences.

30. The method of claim 28 or 29, wherein the pattern recognition method comprises a nonlinear

combination of expression levels of the target sequences.

3 1. A kit for characterizing the expression of one or more nucleic acid sequences depicted in

SEQ ID NOs: 1-21 14 comprising one or more nucleic acids selected from:

(a) a nucleic acid depicted in any of SEQ ID NOs: 1-21 14;

(b) an RNA form of any of the nucleic acids depicted in SEQ ID NOs: 1-21 14;

(c) a peptide nucleic acid form of any of the nucleic acids depicted in SEQ ID NOs: 1-

2 114;

(d) a nucleic acid comprising at least 20 consecutive bases of any of (a-c);

(e) a nucleic acid comprising at least 25 consecutive bases having at least 90% sequence

identity to any of (a-c); or

(f) a complement to any of (a-e); and

optionally instructions for correlating the expression level of said one or more nucleic

acid sequences with the disease state of prostate cancer tissue.

32. The kit of claim 3 1, wherein said one or more nucleic acids comprises one or more

sequences as set forth in any one of SEQ ID NOs: 1, 4, 6, 9, 14-16, 18-21 915-917, 920, 922,

928, 929, 931, 935 and 936.

33. The kit of claim 3 1, wherein said one or more nucleic acids comprises one or more of the

sequences as set forth in SEQ ID NOs: 3, 36, 60, 63, 926, 971, 978, 999, 1014 and 1022.

34. The kit of claim 3 1, wherein said one or more nucleic acids comprise s one or

more of the sequences as set forth in SEQ ID NOs 1-3, 32, 33, 36, 46, 60, 63, 66, 69, 88, 100,

241, 265, 334, 437, 920, 925, 934, 945, 947, 954, 971, 978, 999, 1004, 1014, 1022, 1023, 1032,

1080, 1093, 1101, 1164, 1248, 1304, 13 11, 1330, 1402, 1425.

35. The kit of any one of claims 3 1 to 34, wherein said one or more nucleic acids

comprises labeled nucleic acids.

36. The kit of any one of claims 3 1 to 35, wherein the kit comprises one or more primers

or primer pairs that specifically amplify at least a portion of said nucleic acids.

37. The kit of any of claims 3 1 to 36, wherein the kit further comprises one or more

control samples comprising expressed RNA, an amplification product produced therefrom or a

surrogate therefore, said control one or more control samples selected from:

a sample from non-recurrent prostate cancer; and

a sample from recurrent prostate cancer.

38. An array of probe nucleic acids certified for use in expression-based assessment of

prostate cancer recurrence risk, wherein said array comprises at least two different probe nucleic

acids that specifically hybridize to corresponding different target nucleic acids depicted in one of

SEQ ID NOs: 1-21 14, an RNA form thereof, or a complement to either thereof.

39. The array of claim 38, further comprising one or more probe nucleic acids that

specifically hybridize to house keeping genes.

40. A device for classifying a biological sample from a prostate cancer as recurrent or

non-recurrent, the device comprising:

means for measuring the expression level of one or more transcripts of one or more genes

selected from the group of genes set forth in Table 3 and/or 6;

means for correlating the expression level with a classification of prostate cancer status;

and

means for outputting the prostate cancer status.

4 1. The device of claim 40, wherein the machine utilizes an algorithm to characterize

said expression level.

42. A computer-readable medium comprising one or more digitally-encoded expression

pattern profiles representative of the level of expression of one or more transcripts of one or

more genes selected from the group of genes set forth in Table 3 and/or 6, each of said one or

more expression pattern profiles being associated with a value wherein each of said values is

correlated with the presence of recurrent or non-recurrent prostate cancer.

INTERNATIONAL SEARCH REPORT International application No

PCT/CA2009/000694

A CLASSIFICATION OF SUBJECT MATTERIPC C40B 40/06 (2006 01) , C12Q 1/68 (2006 01) , C40B 30/04 (2006 01) , C07H 21/00 (2006 01)According to International Patent Classification (IPC) or to both national classification and IPC

B FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols)

IPC C40B 40/06 (2006 01) , C12Q 1/68 (2006 01) , C40B 30/04 (2006 01) , C07H 21/00 (2006 01)

Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched

Electronic database(s) consulted durmg the international search (name of database(s) and, where practicable, search terms used)GenomeQuest, Delphion, Esp@cenet, Canadian Patent Database and NCBI, Authors Daviciom E and Bibikova M, Keywords prostate,cancer, biomarkers, expression and genes listed m Table 3 andr Table 6

C DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No

X WO 01/60860 A2 (SCHLEGEL, R et al ) 23 August 2001 (23-08-2001) 1-1 1, 13-21, 23-32 and 34-42*see entire document*

X BIBIKOVA,M et al Expression signatures that correlated with Gleason score 1-3, 6, 14 and 40-42and relapse in prostate cancer Genomics 24 April 2007, VoI 89, No 6, pages666-672, ISSN 1089-8646*see entire document*

A COOPER, C S et al Mechanisms of Disease biomarkers and molecular targets 1-42from microarray gene expression studies in prostate cancer Nat CIm PractUrol December 2007, VoI 4, No 12, pages 677-687, ISSN 1743^289*see entire document*

[X] Further documents are listed in the continuation of Box C [X ] See patent family annex

Special categories of cited documents T later document published after the international films date or prioritydate and not m conflict with the application but cited to understand

A document defining the general state of the art which is not considered the principle or theory underlying the inventionto be of particular relevance

X document of particular relevance the claimed invention cannot beE earlier application or patent but published on or after the international considered novel or cannot be considered to involve an inventive

filing date step when the document is taken alone

L document which may throw doubts on priority claim(s) or which is Y document of particular relevance the claimed invention cannot becited to establish the publication date of another citation or other considered to involve an inventive step when the document isspecial reason (as specified) combined with one or more other such documents such combination

being obvious to a person skilled m the artO document referring to an oral disclosure use exhibition or other means

& document member of the same patent familyP document published prior to the international filing date but later than

the priority date claimed

Date of the actual completion of the international search Date of mailing of the international search report

7 October 2009 (07-10-2009) 14 October 2009 (14-10-2009)

Name and mailing address of the ISA/CA Authorized officerCanadian Intellectual Property OfficePlace du Portage I, Cl 14 - 1st Floor, Box PCT Sudeep Acharya (819) 994-424150 Victoria StreetGatmeau, Quebec KlA 0C9Facsimile No 001-819-953-2476

Form PCT/ISA/210 (second sheet ) (My 2009) Page 3 of 5


PCT/CA2009/000694

C (Continuation) DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No

A MENDIRATTA, P and FEBBO, P G Genomic signatures associated with the 1-42development, progression, and outcome of prostate cancer Cancer 2007, VoI 11,

No 6, pages 345-354, ISSN 1177-1062*see entire document*

Form PCT/ISA/210 (continuation of second sheet) (July 2009) Page 4 of 5


Information on patent family members PCT/CA2009/000694

Patent Document Publication Patent Family PublicationCited in Search Report Date Member(s) Date

WO 0 160860A2 23-08-2001 AU 4154101A 27-08-2001US 2004259086A1 23-12-2004WO 0160860A3 13-06-2002

Form PC17ISA/210 (patent family annex ) (July 2009) Page 5 of 5

WO 2009/143603 Al

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