Role of Fat-Soluble Vitamins A and D in the Pathogenesis of Influenza: A New Perspective

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Transcript of Role of Fat-Soluble Vitamins A and D in the Pathogenesis of Influenza: A New Perspective

Page 1: Role of Fat-Soluble Vitamins A and D in the Pathogenesis of Influenza: A New Perspective
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Page 3: Role of Fat-Soluble Vitamins A and D in the Pathogenesis of Influenza: A New Perspective
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25

20

15

10

5

0

(%)

Winter Spring Summer Autumn

Placebo800 IU/d2000 IU/d

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Vitamin A (retinol)

ADH1ADH4ADH5

Retinal

APC

ALDH1a1

ALDH1a2

Th-17 cellsHigh dose

Mucosal homing T cells

CCR9+

α4β7+

Retinoic acid (RA)

RAR/RXR

Naı̈ve T cells

CCR9−

α4β7−

TGF-β/IL-10

IL-5IL-6

CCR9+

α4β7+

IgA+

FoxP3+Tregs

CCR9+

α4β7+

B cell

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