Neurological Board Examination （I） 2012 09 08

A type: Select the one best answer to each question.

( ) 1. Which of the following statements about Korsakoff syndrome is WRONG?

A. Creative falsification of memory in an alert, responsive state

B. Disintegrity of certain aspects of behavior and mental function such as arousal

or attention

C. An impaired ability to recall events and other information that had been firmly

established before the onset of the illness

D. An impaired ability to acquire new information, i.e., to learn or to form new

memories

E. Lacking in initiative, spontaneity, and insight

解答： B 出處：Adams and Victor's neurology chapter 21, 9th edition, P410 Section: memory and the amnesic syndrome

( ) 2. Correct statement about the syndrome of alexia without agraphia

A. Often with lesions in frontotemporal regions

B. Associated with left homonymous hemianopia

C. Often with lesions in the splenium of the corpus callosum

D. Difficulties in dictating words

E. Lesions disconnecting the angular gyrus, Wernicke and Broca areas

解答： C 出處：Adams and Victor Chapter 22, section on "disconnection syndromes

( ) 3. Choose one clinical suggestive feature for dementia with Lewy bodies?

A. Cognitive decline which compromises daily function

B. Posture imbalance and gait difficulty

C. Rapid eye movement sleep behavior disorder

D. Recurrent visual hallucinations

E. Fluctuating cognition and alertness

解答： C 出處：Merritt’s Neurology, 12th ed, 2012, p. 721

( ) 4. Which of the following statements about Narcolepsy is WRONG?

A. Daytime sleepiness is usually the first and most prominent symptom

B. Sleep paralysis is a global paralysis of voluntary muscles that occurs at the end

of sleep

C. Cataplexy is precipitated by strong emotions

D. Cataplexy lasts seconds to minutes, without change in consciousness

E. Hypnagogic hallucinations are vivid dreamlike images that occur during sleep

onset or at sleep offset (hypnopompic)

解答： B 出處：Merritt's Neurology, 12th Edition. P971-972

( ) 5. Which of the following is related to tauopathy ?

A. Frontotemporal dementia with ubiquitin (FTD-U)

B. Progressive supranuclear palsy (PSP)

C. Parkinson’s disease with dementia (PDD)

D. Dementia with Lewy body (DLB)

E. Creutzfeldt-Jakob disease (CJD)

解答： B 出處：Merritt’s Textbook of Neurology, 12th Edition, Chap. 112, p710-711

( ) 6. Which of the following statements about Alzheimer disease is WRONG?

A. Memory impairment for newly acquired information

B. Delusions and psychotic behavior increase with progression

C. Lower Aβ42 and tau level in CSF

D. EEG showed generalized slowing without focal features

E. Early studies in PET showed hypometabolism in the posterior parietal lobes

解答： C 出處：Merrit’s Neurology, 12th edition, P.713-715

( ) 7. A 66 years old man was noted by his family to have progressive deterioration of

non-fluent speech, word finding difficulty and some paraphasia since 3 years ago.

Later on he was noted to have impaired working memory, attention, and

depressive mood. About one year ago, he had generalized weakness and muscle

atrophy and was suspected to have motor neuron disease. Which of the following

statement is MOST LIKELY concerning to his condition?

A. This is the most common type of dementia in Taiwan

B. In general, this is more common in men than in women

C. A FDG-PET scan might show frontotemporal hypometabolism

D. Both donepezil and rivastigmine are effective medications

E. Patients with comorbid motor neuron disease have a much longer life span

解答： C 出處：Merritt’s Neurology, 12th edition p. 718

( ) 8. Which of the following statements is TRUE about genetic basis of Alzheimer’s

disease (AD)

A. Presenilin 2 (PSEN2) gene mutation is the most common form of familial

early-onset AD.

B. Presenilin 1 (PSEN1) mutation leads to the aggregation of the amyloid-β p

eptide by interfering with β-secretase processing.

C. ε4 polymorphism of the Apolipoprotein E(APOE) gene is closely associated

with familial AD as well as sporadic form AD.

D. patients with one APOE-ε4 allele have more increased risk than those having

two copies.

E. APOE has been called a “causative” gene because possession of the

ε4 allele usually lead to AD.

解答： C 出處：Merritt's Neurology 12th Edition P.716

( ) 9. Which is CORRECT about the Sturge-Weber syndrome?

A. The temporal lobe is most often affected

B. The distribution of facial nevus is limited to ophthalmic trigeminal sensory

area

C. Seizures usually develop after age 5

D. Facial nevus may be absent in some cases

E. Cataract is the main ophthalmological problem

解答：(D) 出處：Merritts 12th ed, p.705-707

( ) 10. Which of the following is CORRECT about the descriptions of different sleep

stages?

A. K complexes are usually seen in slow-wave sleep (stage N3)

B. The variability in heart and respiratory rates is greater in non-REM sleep

compared with REM sleep stages.

C. The first REM sleep period occurs 120 to 150 minutes into sleep

D. REM sleep periods increase in duration and intensity of REM activity as the

night progresses

E. Stage N1 sleep is the most common sleep stage.

解答：(D) 出處：Merritt’s Neurology, 12th edition, p. 967

( ) 11. Which statement about acute intermittent porphyria is WRONG ?

A. Abdominal pain is most common symptom and may occur alone or with a

neurologic or psychiatric disorder

B. In acute attacks of porphyria, seizures may be treated with phenytoin

C. There may be fever, leukocytosis and diarrhea when acute attack

D. The neuropathy and abdominal symptoms may respond dramatically to

hematin

E. Even between attacks, affected individuals can be identified by a qualitative

test for porphobilinogen (PBG) in the urine

解答： B 出處：Merrit’s Neurology, 12th edition, p662-663

( ) 12. Which of following statements about alcohol and alcoholism is WRONG ?

A. In nonhabituated persons, at a blood alcohol level of 100 mg/dl, ataxia was

obvious.

B. More than 90 % of alcohol-withdrawal seizures occur during 7- to 48-h

period following the cessation of drinking.

C. Focal seizures are common in alcohol withdrawal seizures.

D. Antiepileptic drugs are not regularly needed in the management of

alcohol-withdrawal seizures.

E. The most common single manifestation of the alcohol-withdrawal syndrome

is tremulousness.

解答：C 出處： Adams & Victor’s Principles of Neurology, 9e P. 1134-1135

( ) 13. Which of the following can be the complication of bariatric surgery (weight-loss

surgery)?

A. Dry beriberi

B. Wernicke encephalopathy

C. Guillian-Barre syndrome

D. Korsakoff syndrome

E. All of the above

解答： E 出處： Merritt’s Neurology, 12th edition, p. 1037

( ) 14. Which statement about hepatic encephalopathy was WRONG?

A. Fatty acids inhibit the urea cycle and lead to hyperammonemia

B. Elevated blood ammonia levels correlate with the severity of the

encephalopathy

C. Alzheimer’s type II neuron present

D. Increase in peripheral type of BZD receptor

E. Decrease in postsynaptic glutamate receptor

解答： C 出處：NICP 5th Ed, p. 1624-1631

( ) 15. Which of the following does NOT impair pre-synaptic neuromuscular

transmission?.

A. Tick paralysis

B. Botulism

C. Lambert-Eaton syndrome

D. Snake venom toxins

E. Episodic apnea

解答： D 出處：Adam and Victor’s principles of neurology 9th Ed, p, 1416

( ) 16. Which of the followings does NOT belong to acute ethanol withdraw syndrome ?

A. Tremulousness

B. Hallucinosis

C. Seizure

D. Delirium tremens

E. Polyneuropathy

解答：E 出處：Merrit’s Neurology 11TH , p1077, 1079

( ) 17. Which of the following statements is WRONG about Hashimoto

encephalopathy?

A. The clinical manifestations are diverse, patients may develop a progressive

mental decline with dementia and psychiatric symptoms

B. The antithyroglobulin or antithyroid peroxidase levels are elevated

C. The CSF protein concentration is often increased

D. EEG tracings are almost always abnormal

E. In general, patients respond poorly to steroid therapy

解答： E 出處：Merritt’s Neurology, 12th edition, p. 1051-1052

( ) 18. A 60-year-old man has 2-year history of leg shaking when standing. He noted

that when he is standing he feels unsteady and has tremor in his legs. His

symptoms are worst while standing still and improve when walking or sitting.

Examination shows a high-frequency tremor in his legs when he stands that

improves when he walks; gait is normal, and the rest of his neurological

examination is normal. Which of the following is the MOST LIKELY

diagnosis?

A. Restless leg syndrome

B. Periodic limb movement

C. Paroxysmal kinesigenic dyskinesia

D. Orthostatic tremor

E. Parkinson disease

解答： D 出處：Adams and Victor’s Principles of Neurology, 9th edition, p.94

( ) 19. Which of the following statements about Huntington Disease is TRUE ?

A. The length of the CAG repeat is the most important factor in determining age

of onset of Huntington Disease.

B. The usual age of onset is younger than 20 years.

C. Wesphal variant is more common with an adulthood onset.

D. Oculomotor function is rarely affected.

E. Huntington disease is an incurable, autosomal recessive inherited

disorder

解答： A

出處：Adams & Victor’s Principles of Neurology, 9e P. 1027-1028

( ) 20. A 12 years old boy was found by his school teacher to have easy falling during

physical exercise classes. The teacher described that during the basketball game

in the class, he made some strange twisting movement of his body when he got

the ball and was about to shoot the basket, and that is the time he would fall

down. Sometimes he had jerking movement of his hands and arms when doing

gymnastic exercise. What is the MOST LIKELY condition he had?

A. there might be a family history with AR inheritance

B. the abnormal movement could be triggered by startle or hyperventilation

C. Acetazolamide is the only drug of choice

D. he might have 12p13, potassium channel gene mutation in KCNA1

E. Clinical diagnosis is episodic ataxia

解答： B 出處：Merritt’s Neurology, 12th edition p.775 - 777

( ) 21. Which one of the following statements about myoclonus is WRONG?

A. The electromyographic discharges of myoclonus usually last 10 to 100

milliseconds.

B. Primary palatal myoclonus may persist during sleep.

C. Propriospinal myoclonus is usually triggered by a stimulus such as when the

knee jerk is elicited.

D. Spinal segmental myoclonus is usually rhythmic and persists during sleep

E. Median nerve stimulation may not evoke giant cortical responses in all the

subjects with cortical myoclonus.

解答：(B)

出處：Merritt’s Textbook of Neurology 12th Edition P 732 

( ) 22. Which one of the following statements about dystonia is WRONG?

A. Dystonia often exacerbates during voluntary movements,

B. Dystonia increases with fatigue, stress, and emotional states.

C. The older the age at onset, the more likely the dystonia will become severe.

D. The most common focal dystonia is cervical dystonia.

E. Segawa's disease, also known as dopa-responsive dystonia with diurnal

fluctuation, is a genetic movement disorder which usually manifests itself

during early childhood at around ages 5–8 years.

解答： (C) younger

出處：Merritt’s Textbook of Neurology 12th Edition P 738

( ) 23. Which one of the following descriptions about familial Parkinson’s disease

caused by Parkin mutation is CORRECT ?

A. Autosomal-dominant inheritance

B. Mostly presents as late-onset parkinsonism

C. Clinical course is rapidly progressive

D. Vulnerable to dyskinesia after levodopa treatment

E. Lewy bodies are common pathological findings

解答： D 出處： Merritt’s Neurology (12th edition). P.745.

( ) 24. The following disease is WRONG for diet and L-dopa?

A. The majority of absorption takes place in the stomach.

B. Amino acids complete for absorption of L-dopa

C. Low-protein diet has been advocated as a means of controlling the motor

fluctuations.

D. Dietary protein restriction may reduce the total daily dose of L-dopa.

E. The absorption of L-dopa may be impaired by the presence of gastric

Helicobacter pylori infection

解答： A

出處：Adams and Vicotr’s Principles of Neurology 9 e/d P. 1044

( ) 25. Which of the following descriptions about hyperekplexia (excessive startle

syndrome) is WRONG?

A. May be caused by gene mutation of the glycine receptorα1 subunit

B. The myoclonic jerks may arise from the brainstem

C. Is often resistant to clonazepam treatment

D. Can be inherited in autosomal dominant trait

E. When appears in infancy, patients may manifest as a stiff baby

解答： C 出處： Merritt’s (12th) 733

( ) 26. A 57 year-old man developed left focal hand dystonia for 1 year and

the surface EMG revealed the following pattern . Which of the following

diagnosis is MOST LIKELY?

A. Corticobasal ganglionic degeneration

B. Parkinson disease

C. Dementia with Lewy bodies

D. Task specific dystonia

E. Dopa responsive dystonia

解答： A 出處：Merritt’s(12th) 773

( ) 27. Which of the following is WRONG about dentatorubral-pallidoluysian atrophy?

A. Expansion of CAG repeat

B. Prominent anticipation

C. Early onset cases display myoclonus, epilepsy and cognitive decline

D. Late onset cases display chorea, dementia and psychiatric problems

E. Retinopathy

解答： E 出處：Merritt’s Neurology, 12th edition, p. 798

( ) 28. Which is NOT suggestive of symptomatic dystonia ?

A. Onset of dystonia at action

B. Early onset of speech involvement

C. Leg involvement in an adult

D. Hemidystonia

E. Presence of neurological abnormalities aside from dystonia

解答： A 出處：Merrit’s Neurology 11TH , p745

( ) 29. Which of the following conditions does NOT provoke restless leg syndrome?

A. Anemia

B. Peripheral vascular disease

C. Antidepressants

D. Benzodiazepines

E. Iron deficiency

解答： D 出處：Merritt’s 12th Ed, p.970-971

( ) 30. Which one of the following is NOT the diagnostic criteria for neuromyelitis

optica

A. Optic neuritis

B. Acute myelitis

C. Spinal cord MRI lesion extending at least 3 contiguous vertebral segment

D. Initial brain MRI with more than 4 white matter lesion

E. AQP4 seropositivity

解答： D 出處：Merrit’s Neurology, 12th edition, p919-920

( ) 31. Which of the following is LEAST LIKELY the differential diagnosis of spastic

paraplegia in middle aged adults?

A. Multiple sclerosis

B. Amyotrophic lateral sclerosis

C. Kennedy disease

D. Vitamin B12 deficiency

E. Adrenoleukodystrophy

解答： C 出處：Merritt’s neurology 12th edition, p.806

( ) 32. Which of the following statements about acute disseminated encephalomyelitis

(ADEM) is WRONG ?

A. It is an acute inflammatory and demyelinating disease

B. Demyelinating course in brain white matter, brain stem, spinal cord and

peripheral nerves

C. Common involve children follows a febrile illness by days or weeks

D. Initial few days with onset of the exanthema of measles, rubella, smallpox, or

chickenpox.

E. May also noted in post vaccine injection state (rabies vaccine)

解答： B 出處： Principle of Neurology, 9ed, PP: p. 896-900

( ) 33. Which of the following test is LEAST LIKELY to be abnormal in late stage

Meniere’s disease?

A. Electrocochleography (ECoG)

B. Electronystagmography (ENG)

C. Audiometry

D. Caloric test

E. Computed tomography (CT) of inner ear

解答： E 出處：Merritt’s Neurology, 12th edition p. 963-966

( ) 34. A 72 year-old man who suffered from lateral medullary infarction one year ago is

admitted to neurological intensive care unit due to major right middle cerebral

artery infarction. He has abnormal breathing during sleep and nocturnal

paroxysmal events. Which of the following statements is CORRECT?

A. He has Cheyne-Stokes breathing caused by previous brain stem stroke.

B. If the EEG shows periodic lateralized epileptiform discharge (PLED) in right

brain area, his nocturnal attacks are most likely seizure.

C. If he has dysarthria, dysphagia and loud snoring, he may need continuous

positive airway pressure (CPAP) therapy.

D. If he has jerky movement on his left lower limb during sleep, antiepileptic

drugs should be given.

E. If he has dream-enacting behavior during sleep, antidepressants should be

given.

解答： C 出處：Merritt’s Neurology (12th ed.) p.969-974

( ) 35. A 64 year-old woman who has been suffering from myasthenia gravis for 30

years is currently at Osserman stage IIb. She complains both insomnia and

excessive daytime sleepiness. Which of the following statements is CORRECT?

A. Steroids therapy has no effect on her sleep.

B. End tidal or transcutaneous CO2 monitoring is useful for the diagnosis of sleep

hypoventilation syndrome.

C. Pyridostigmine can make obstructive sleep apnea worse.

D. The drug therapy for her insomnia is safe.

E. If she has REM sleep behavior disorder, the drug therapy is also safe.

解答： B

出處：Merritt’s Neurology (12th ed.) p.969-974

( ) 36. A 75 year-old patient with Parkinson’s disease (PD) at Hoehn and Yahr stage III

complains nocturnal sleep disturbance and excessive daytime sleepiness. Which

of the following statements is CORRECT?

A. Dopamine agonist is an exclusive cause for his sleepiness and should be

discontinued.

B. REM sleep behavior disorder is common in PD.

C. Restless legs syndrome is likely and can be treated by iron supplement.

D. Methylphenidate is the drug of choice for his sleepiness.

E. Cheyne-Stokes breathing is the most common type of sleep-disordered

breathing in PD.

解答： B 出處：Merritt’s Neurology (12th ed.) p.969-974

( ) 37. Which of the following is WRONG about benign positional vertigo?

A. The vertigo attacks is paroxysmal and occurs only with the assumption of

certain position of head.

B. It can be diagnosed at the bedside through Dix and Hallpike maneuver.

C. It is caused by detached otolith to the cupula of the anterior semicircular

canal.

D. It may be treated by canalith repositioning maneuver.

解答： C 出處： Adam’s : Principle of Neurology 9 th ed page 293-6

( ) 38. What is NOT the typical feature of a syncope event?

A. Blurring of vision

B. Pale or ashen appearance of the skin

C. Anhydrosis and nausea

D. Urge to urinate or defecate

E. Loss of muscle tone

解答： C 出處：Merritt’s 12th Ed, p.15-16

( ) 39. About laboratory tests for dermatomyositis, which of the following statements is

WRONG

A. The serum creatine kinase (CK) concentrations are usually elevated in

dermatomyositis but can be normal earlier in the course

B. Serum CK levels well reflect activity of the disease

C. Anti-Jo-1 antibody present in more than 20% of patients with

dermatomyositis and had association with interstitial lung disease

D. Anti Mi-2 are associated with the relatively acute onset of classic DM with

erythroderma and the shawl sign

E. Antinuclear antibody and rheumatoid factor may be positive

解答： B 出處：Clinical practice of neurology 5th Edition 2008 p.2440-2442

( ) 40. Which of the following diseases will NOT usually present as facial diplegia?

A. Neurosarcoidosis

B. Ramsey Hunt syndrome

C. Mobius syndrome

D. Congenital myotonic muscular dystrophy

解答：(B) 出處：Merritt's Neurology 12th edition, p. 212, 602

( ) 41. About Lambert-Eaton myasthenic syndrome (LEMS), which one is WRONG?

A. Antibodies are directed against voltage-gated sodium channels in peripheral

nerve terminals

B. The neurologic symptoms frequently precede those of the tumor.

C. Most LEMS cases occur with small cell carcinoma of the lung.

D. Autonomic symptoms are more common in LEMS than in MG

E. At rates greater than 10 Hz, the repetitive nerve stimulation shows a marked

increase in the amplitude of evoked response.

解答： A 出處：Merritt's Neurology, 12th Edition p. 851

( ) 42. Which one is NOT helpful for diagnosis of myasthenia gravis?

A. Repetitive nerve stimulation: a reproducible 10% increment in amplitude

when comparing the first stimulus to the fourth or fifth.

B. single fiber EMG (SFEMG): jitter is increased in the forearm extensor

digitorum communis.

C. ocular cooling: cooling of a ptotic lid improves lid elevation.

D. may check serum anti–muscle-specific tyrosine kinase (MuSK) antibody.

E. edrophonium test:. improvement in eyelid ptosis

解答： A 出處：Neurology in Clinical Practice, 5th ed p. 2386-2388

( ) 43. Which one is NOT the characteristic in facioscapulohumeral muscular dystrophy

(FSHMD)?

A. Bulbar, extraocular and deltoid muscles are spare

B. Autosomal dominant with nearly complete penetration

C. Endomysial or perivascular inflammatory infiltration was found in the

muscle pathology

D. Level of serum creatine kinase is often very high

E. Often asymmetric in facial and scapular weakness

解答： D

出處：Merritt’s Neurology, 12th edition, p866-867

( ) 44. Which of the following descriptions about features to distinguish Amyotrophic

lateral sclerosis (ALS) and multifocal motor neuropathy (MMN) is WRONG?

A. MMN primarily affects the hands, is asymmetric, affects men more than

women and is predominantly lower motor neuron.

B. Conduction block in more than one nerve and not at the sites of entrapment

neuropathy is mainly the feature of MMN, but may also noted in ALS

C. Progression pattern is the important distinguishing features and MMN

progresses more slowly than ALS, so that relatively little disability after 5

years of symptoms favor the diagnosis.

D. MMN with conduction block generally exhibit a good response to the

immunosuppressive therapy or IVIG

E. The combination of active tendon jerks and lower motor neuron signs, which

is the features of ALS, is never noted in MMN patients without other

concomitant lesions.

解答： E 出處：Merrit’s neurology 12th P. 806

( ) 45. According to the genetic mutation of Charcot-Marie-Tooth (CMT), which of the

following description is WRONG?

A. CMT1B is related to myelin protein zero (MPZ) gene duplication.

B. CMT1A is caused by 1.4Mb duplication of PMP22

C. HNPP is 1.4Mb deletion of PMP22, same portion as in CMT1A

D. Mutations in MFN2 cause CMT2A

E. CMT X (XD) may be caused by Connexin-32 gene point mutation

解答： (A) 出處： NICP 5th, p2274 (2008)

( ) 46. Which of the following inherited neuropathies is associated with vocal cord and

diaphragm paralysis?

A. Charcot-Marie-Tooth disease type 1B

B. Charcot-Marie-Tooth disease type 2C

C. Charcot-Marie-Tooth disease type 4A

D. Hereditary sensory and autonomic neuropathy type 1

E. Hereditary sensory and autonomic neuropathy type 2

解答： B 出處：Merritt’s Neurology p818

( ) 47. Which one of the followings will NOT be seen in neurogenic disease during

needle electromyography examination ?

A. Fibrillations

B. Fasciculations

C. Long duration, high amplitude MUAPs

D. Early recruitment

E. Incomplete interference pattern

解答： D 出處：Merritt’s Neurology, 12th edition, P85-87

( ) 48. A 60-year-old man presents with year history of progressive and painless

weakness predominantly involving the flexors of the fingers, wrist, hip and the

quadriceps muscles. The muscle biopsy specimen is MOST LIKELY be

A. Perifascicular muscle fiber atrophy and perivascular inflammatory infiltrates

B. Ragged red fibers

C. Nemaline rods

D. Rimmed vacuoles, intracellular β-amyloid deposition in vacuoles

E. infiltration by CD8 lymphocytes and expression of the MHC-1 antigen

解答： D 出處： Meritts p.898~900

( ) 49. Lambert-Eaton Syndrome

A. is caused by a defect of neuromuscular transmission owing to

antibody-mediated attack on nicotinic AChR

B. is NOT an autoimmune disease

C. is characteristic by incremental response to repetitive nerve stimulation at rates

> 10 Hz

D. does not respond to pyridostigmine bromide, even with 3,4-diaminopyridine

E. Only 33% of patients with Lambert-Eaton Syndrome are associated with tumor.

答： C 出處：Merritt’s Neurology, 12th edition, p. 851 & 844

( ) 50. High serum CK (at least 10 times normal) could be seen in the following diseases,

EXCEPT?

A. Duchenne muscular dystrophy

B. Becker muscular dystrophy

C. Myotonic muscular dystrophy

D. Miyoshi distal myopathy

E. Kugelberg-Welander syndrome

解答： C

出處： Merritt(12th) 2010, p.810,864,874

( ) 51. Which of the following description is NOT a typical clinical feature of

Myotonic Dystrophy?

A. Masseter and temporalis muscles atrophy are common

B. Cataracts are almost universal

C. Progressive dementia

D. Cardiac conduction disturbances occur commonly

E. Affect the distal muscles more severely

解答： C

出處：Neurology in Clinical Practice, 3rd edition, p.2208- 2211

( ) 52. Which one is ineffective treatment for neuropathic pain ?

A. Antiepileptic drug

B. Tricyclic antidepressants

C. Serotonin norepinephrine reuptake inhibitor

D. Selective serotonin reuptake inhibitors

E. Tramadol hydrochloride

解答：D

出處：Merritt’s Neurology, 12 edition, 2010, P841

( )53. Which of the following is NOT the typical cranial autonomic symptom seen in

patients with cluster headache?

A. Rhinorrhea

B. Conjunctival injection

C. Anhidrosis

D. Forehead/facial flushing

E. Miosis

解答： C 出處：Principle of Neurology, 9th edition, 174-176

( ) 54. A 36-year-old female bothered from frequent paroxysmal lancinating pain on

her left temporo-orbital region since 2 years ago. The headache occurred many

times per day, with duration lasted for around 2 to 45 minutes. Accompanied

with the headache attacks, she also had nasal stiffness, rhinorrhea, forehead

sweating, and redness & lacrimation of the eye ipsilateral to the headache.

Neuroimage study showed no structural lesions in her head. What’s the

appreciate therapy for this patient’s headache relief?

A. 100% oxygen inhalation via mask

B. Sumatriptan 6mg sc

C. Carbamazepine 200mg po tid

D. Amitriptyline hydrochloride 25-50mg po qn

E. Indomethacin 5-10mg po tid

解答： E 出處： Principles of Neurology 9th Edition 2009 p.162-188

( ) 55. A 68-year-old man with a migraine history develops left temporal headache for

2 weeks, along with generalized malaise, fever, poor appetite, and multiple joint

pain. He also complains of intermittent left eye visual obscuration. Lab study

shows ESR (erythrocyte sedimentation rate) is 100 mm/hour. What is the most

appropriate treatment for his headache?

A. Sumatriptan

B. Prednisolone

C. Verapamil

D. Topiramate

E. Indomethacin

解答： ( B ) 出處：Principles of Neurology, 9th edition, p178-9.

( ) 56. Which of the following image finding is NOT associated with intracranial

hypotension

A. Pituitary hyperemia

B. Subdural effusion

C. Diffuse leptomeningeal enhancement

D. Downward sagging of cerebrum

E. Dural enhancement at cervical spine

解答： C 出處：Principle of Neurology, 9th edition, 606-607

( ) 57. Which of the following symptoms distinguish cluster headache from hypnic

headache?

A. Headache only in sleep

B. Photophobia

C. Cranial autonomic symptoms

D. Responses to lithium

E. Awaken from sleep

解答：C 

出處：Merritt’s Neurology, 12th edition, 956‐958 

( ) 58. Which of the followings is FALSE regarding migraine aura without headache?

A. Most commonly encountered in patients with a past history of migraine with

aura

B. De novo cases usually begin after 40 years of age

C. In patients with history of migraine, the presence of migraine aura without

headache, presenting with scintillating scotoma and zigzag appearance, is an

indication for further brain imaging studies.

D. In children and adolescent, an acute confusional state can occur during the aura

stage

E. Transient ischemic attacks is one of the most important differential diagnosis if

the migraine aura without headache develops in later life

解答：  C 

出處：Neurology in clinical practice, 5th edition, page 2028‐2029 

( ) 59. Elevated total protein level in cerebrospinal fluid(CSF) may be found in

following conditions EXCEPT

A. Diabetic radiculoneuropathy

B. CSF leakage

C. Spinal cord tumor with spinal block

D. Myxedema

E. Bloody fluids

解答： B 出處：Merrit’s Neurology, 12th edition, p113

( ) 60. Which statement about physiological variability in nerve conduction studies is

WRONG?

A. Nerve impulse propagation slows by 2.4 m/s per degree centigrade from

38°C to 29°C.

B. Cooling results in a lower CMAP and SNAP.

C. This measurement correlates linearly with the subcutaneous and

intramuscular temperatures.

D. Adding 5% of the calculated conduction velocity for each degree below 33°C

theoretically normalizes the result.

E. NCV are half the adult values in full-term newborns and attain adult values at

3 to 5 years.

解答： B 出處：NICP 6th Ed, p.398

( ) 61. Which one of the following statements on visual evoked potentials (VEP) is

WRONG?

A. Shifting checkerboard pattern is more sensitive

B. Demyelination results in prolonged latency

C. Compression of optic nerve prolongs VEP

D. Glaucoma severe enough would prolong VEP

E. Impaired visual acuity results in prolonged latency

解答： E 出處： Adams and Victor’s Principles of Neurology, 9th Ed. P. 33-34

( ) 62. Which of the clinical observations or laboratory tests is the best diagnosis of

brain death

A. Hallow skull phenomenon by Technetium-99m

hexamethylpropylene-amineoxime brain scan

B. Sleep apnea or severe pulmonary disease resulting in chronic retention of

CO2

C. No electrical activity of electroencephalography

D. Initial absence of Transcranial Doppler signals

E. Toxic levels of the sedative drugs, aminoglycosides or neuromuscular

blocking agents

解答： A 出處：Merritt’s Section I, Chap 6, p. 29 (Table 6.4)

( ) 63. A 45-year-old male patient developed disorientation and headache; neck stiffness

was found during physical examination, his CSF studies showed: the WBC

172/mm3, glucose 40mg%, protein 750mg%. The MOST LIKELY diagnosis

would be ?

A. Meningeal carcinomatosis

B. Subarachnoid hemorrhage

C. Streptococcus meningitis

D. TB meningitis

E. Fungal meningitis

解答： D 出處： Adam’s : Principle of Neurology 9 th ed page 14

( ) 64. Which of the following descriptions about single fiber EMG is CORRECT?

A. Single-fiber potentials suitable for study must have a peak-to-peak amplitude

greater than 200 uV, rise time less than 300 uS.

B. The expression of the results of single-fiber EMG jitter studies is by the

largest jitter.

C. Jitter has never been abnormal in healthy subjects

D. The jitter is measured one single muscle fiber action potential

E. Jitter analysis is highly specific.

解答： A 出處： NICP p 508

( ) 65. All the following originate from anterior horn cells, axons, or nerve terminals

EXCEPT:

A. Fasciculation potentials

B. Neuromyotonic discharges

C. Myokymic discharges

D. Fibrillation potentials

E. All the above originate from anterior horn cells, axons, or nerve terminals

解答：D 出處：Adams 9th,p1243-5

( ) 66. A 25-year-old female patient presented with fluctuating dysphagia and dysphonia

which improved after rest or taking pyridostigmine. The results of repetitive

nerve stimulation over right median nerve failed to reveal significantly

decremental response at rest or after voluntary exercise at a frequency of 3 Hz.

Which of the following factor is LEAST LIKELY?

A. The patient kept taking pyridostigmine before the test.

B. The patient has median neuropathy.

C. The limb temperature is too high (i.e. >28ºC).

D. The stimulation is not supramaximal.

E. The position of the recording electrode over the muscle during stimulation is

not immobilized.

解答： C 出處：Merritt’s Neurology 12th edition 2010, p. 88 - 89

( ) 67. What kind of situation could find a fixed dilated pupil?

A. Barbiturate intoxication

B. Opiate intoxication

C. Pontine hemorrhage

D. Cholingergic intoxication

E. Bilateral Horner syndrome

解答： A 出處：Merritt’s 12th Ed, p. 23-24

( ) 68. In a patient with “brain death”, he may has

A. Respiration

B. Spinal reflex

C. Ocular bobbing

D. Cerebral function

E. Cough reflex

解答： B 出處：Merritt’s 12th Ed, p.28-29

( ) 69. A 35-year-old woman suffered from sudden onset of blurred vision in right eye

for 1 day. Her visual evoked potentials (VEP) presented as below, Which of the

following statements about this VEP is the MOST APPROPRIATE etiology ?

A. Right temporal lobe lesion

B. Rright parietal lobe lesion

C. Myopia of right eye

D. Hysteria

E. Right optic nerve lesion

解答： E

( ) 70. Which one is LEAST LIKELY seen in patients with bilateral posterior cerebral

artery infarction?

A. cortical blindness

B. Anton syndrome

C. Simultanagnosia

D. Homonymous hemianopia

E. Metamorphopsia

解答： (D) 題目之出處： Merritt's Neurology, 12th Edition, 2010, p 271-272

( ) 71. Which of the following is WRONG for below genetic disorders associated with

stroke regarding the inheritance and features?

Left 

right 

A. MELAS; maternal inheritance; headache, seizures, cortical blindness,

deafness, and episodic vomiting.

B. Protein C deficiency; autosomal dominant; both venous and arterial

thromboembolic events.

C. Homocysteinuria; autosomal recessive; stroke risk increased but not well

quantified.

D. Antithrombin III deficiency; autosomal recessive; very high risk for arterial

events such as MCA infarct.

E. Marfan syndrome; autosomal dominant; intracranial aneurysms and cervical

artery dissections reported.

解答： D 出處：Merritt Neurology, 12th edition, p. 282

( ) 72. Which of the following is NOT one of the manifestations of Fabry Disease?

A. Angiokeretomas in bathing suit distribution

B. Limb pain with febrile illnesses in early childhood

C. Progressive and sudden hearing loss

D. Symptomatic ischemic stroke mostly occurs during childhood

E. Vascular dementia could be seen

解答： D 出處：Merritt’s Neurology, 12th edition, p281, p284

( ) 73. Which of the following is NOT a possible cause of reversible posterior

leukoenceaphalopathy syndrome (RPLS)?

A. Reversible cerebral vasoconstriction syndrome

B. Use of immunosuppressive agents, including cyclosporine, FK-506

C. Postpartum state

D. Susac syndrome

E. Hyperperfusion syndrome after stenting

解答： D 出處：Merritt’s Neurology, 12th edition, p288-289

( ) 74. Which of the following is WRONG about intracerebral hemorrhage (ICH) ?

A. The ICH score can give a reliable prediction of mortality risk at 30 days.

B. The component of the ICH score includes Glasgow coma scale, ICH

volume, intraventricular hemorrhage, gender and infratentorial origin.

C. The most commonly affected structures are the basal ganglia and

thalamus, followed by the lobar region.

D. Cerebellar hemorrhage usually begins abruptly with vomiting and severe

ataxia.

E. MRI techniques such as gradient-recalled echo sequence (GRE), T2 are

highly sensitive for the diagnosis of ICH.

解答： (B) 出處 ：Merritt’s Neurology, 12th edition, p. 276-280

( ) 75. Which artery is responsible for the blood supply of the lower 2/3 of internal

capsule, globus pallidus, uncus, amygdala, and anterior hippocampus ?

A. Posterior cerebral artery

B. Penetrating branches of middle cerebral artery

C. Anterior cerebral artery

D. Anterior choroidal artery

E. Posterior choroidal artery

解答：(D) 出處：Adams 9th edition Figure 34-5

( ) 76. Which treatment for patients with atherothrombotic infarction is WRONG?

A. If the onset of the first symptoms within 3 h, tPA therapy is indicated.

B. The main objective is the amelioration of the existing deficit and the

prevention of future stroke.

C. The administration of anticoagulants is of great value once the stroke is fully

developed.

D. The long-term use of warfarin is also still under critical analysis.

E. Aching in the paralyzed limbs should not be allowed to interfere with

exercises.

解答： (C) 出處：(from Principle of Neurology, 9th ed, 2009, p.783-786)

( ) 77. Which of the following statement about lacunar infarction is WRONG?

A. The most common presenting syndrome is pure motor hemiparesis.

B. The most common involving vascular territory is middle cerebral artery

penetrant.

C. “strategic infarct dementia syndrome” indicates bilateral multiple subcortical

infarctions.

D. The possible pathogenesis is microatheroma or lipohyalinosis stenosing one

of the deep penetrating arteries.

E. The arterial damage is usually the result of long-standing hypertension or

diabetes mellitus.

答： C 出處：Merritt's neurology, 12th edition, P256

( ) 78. Which of the following description about ultrasonography is CORRECT?

A. Hyperechoic carotid plaque is indicative of high risk of plaque rupture even

the stenotic degree is less than 50 %.

B. Normal flow direction of the ophthalmic artery is the most crucial parameter

indicating a less than 80 % internal carotid artery stenosis.

C. Increased flow velocity is the most common feature for intracranial arterial

stenosis on transcranial Doppler exam.

D. The flow velocity of MCA M1 segment is usually lower than M2 divisions.

E. The typical Doppler waveforms of the feeding arteries of the arterio-venous

malformation are high peak flow velocity and high flow resistance.

解答：C 出處：Merrits p98-100;

( ) 79. Exclusion criteria for administration of rtPA in the NINDS rtPA trial does NOT

include?

A. Current use of dual antiplatelet (aspirin and clopidogrel)

B. A prolonged aPTT or use of heparin in the previous 48 hours

C. Platelet count less than 100,000/mL

D. Blood glucose less than 50 mg/dL or greater than 400 mg/dL

E. Improving or isolated minor neurological deficits

解答： A 出處： Neurology in Clinical Practice

( ) 80. Which is WRONG for Subarachnoid hemorrhage?

A. Saccular (or berry) aneurysms at the base of the brain cause 80%

of all cases of SAH

B. The most important determinant of outcome after SAH is the

patient's neurologic condition on arrival at the hospital

C. Most mortality is related to delayed ischemia from vasospasm

D. The risk of aneurysmal rebleeding is highest within the first 24 hours after the

initial aneurysmal rupture (4%) and remains elevated (approximately 1% to

2%/day) for the next 4 weeks

E. Endovascular coil embolization is an effective alternative to surgical clipping

for asymptomatic unruptured aneurysms.

解答： C 出處： Merritt’s Neurology 12th edition , chapter 47 P. 308~316

( ) 81. Which one is MOST PROPABLE chain events sequence about the “ischemic

cascade” ?

1. The influx of Calcium

2. The depolarization of the neuronal membrane

3. The failure of Na/K pump

4. Damage to organelles and further destabilization of neuronal metabolism

A. 4->1->3->2

B. 2->1->3->4

C. 3->2->1->4

D. 1->3->4->2

E. 1->2->3->4

解答： C 出處： Merritt’s Neurology (12th ed.) p. 253

( ) 82. About preeclampsia and eclampsia, which one is WRONG?

A. Preeclampsia is associated with hepatic and coagulation abnormalities,

hypoalbuminemia and hemoconcentration (but decreased urate levels).

B. Eclampsia is manifested by seizures, cerebral bleeding, and death.

C. Early MRI with gadolinium might reveal posterior sulcal hyperintensity and

leptomeningeal enhancement before the appearance of posterior reversible

encephalopathy syndrome.

D. Pathologic examination of eclamptic brains revealed petechial hemorrhages

in cortical and subcortical patches.

E. Ring hemorrhages about capillaries and precapillaries occluded by fibrinoid

material.

解答： A 出處：Merritt’s Neurology, 12th ed, 2012 p. 1044-1045

( ) 83. Which of the following is LEAST LIKELY seen in patients with Hashimoto

encephalopathy?

A. Seizures

B. Myoclonus

C. Psychosis

D. Focal deficit

E. Relapsing-remitting course

解答： D 出處： Merritt(12th) 2010 p.1051

( ) 84. About the Lennox-Gastaut Syndrome, which of the following statement is

WRONG?

A. Clinical presentation are mainly generalized tonic, atonic, and atypical

absence seizure

B. Characteristic interictal EEG of generalized slow spike-and-wave discharges

(<2.5Hz) in waking and bursts of paroxysmal fast activity (10Hz) in sleep

C. Patients usually have cognitive and behavior abnormalities

D. The syndrome usually starts between 1 and 7 years

E. More than 80% of cases the syndrome occurs in children suffering from a

previous encephalopathy

解答： E 出處: NICP 5th ed, 2008, page 1922; The Epilepsies, 2005, page 159

( ) 85. Which one of the following anti-epileptics drugs has NO effect on the GABA

receptor?

A. Valproic acid

B. Levetiracetam

C. Phenobarbital

D. Tiagabine

E. Topiramate

解答： B 出處：Neurology in Clinical Practice, 4th edition, p.1983-1986

( ) 86. Which of the following is NOT a cytochrome P-450 enzyme inducer?

A. Phenytoin

B. Carbamazepine

C. Phenobarbital

D. Valproate

E. Topiramate

解答： D 出處：Merritt’s Neurology, 12th edition, p. 941

( ) 87. Which of the following is NOT mainly metabolized by kidney

A. Gabapentin

B. Pregabalin

C. Vigabatrin

D. Tiagabin

E. Levetiracetam

解答： D

出處：NICP 5th Ed, p.1937

( ) 88. Which of the following one is WRONG about the Rasmussen encephalitis?

A. Antibodies to glutamate receptor subunit 3 are discovered in some patients

B. Generalized seizure is mostly noted in the early stage.

C. The progression of the disease led to hemiplegia or other deficits and focal

brain atrophy.

D. The use of immunotherapy may be beneficial, such as corticosteroids,

intravenous immunoglobulin, and tacrolimus.

E. Early hemispherectomy may improve weakness

解答：B 出處：Adams 9th,p323

( ) 89. Which of the followings is NOT correct regarding epilepsia partialis continua

(EPC)?

A. Focal lesions including strokes and cerebral metastasis are potential underlying

etiologies.

B. Metabolic encephalopathies especially hypoglycemia with serum glucose

<30mg/dl are a common cause.

C. Rasmussen syndrome is an important differential diagnosis in children if the

onset of EPS was < 10 years of age

D. Common MRI abnormalities in Rasmussen syndrome include unilateral

cortical atrophy and gliosis.

E. EPC can be classified within the cortical myoclonus spectrum

解答： B 出處： Merritt’s Neurology, 12th edition, p931

( ) 90. Which of the followings is NOT a indication of hemispherectomy to treat

epilepsy?

A. Sturge-Weber disease

B. Rasmussen syndrome

C. Intractable Lennox-Gastaut syndrome

D. Hemimegalencephaly

E. Infantile hemiplegia syndrome

解答： C 出處：Merritt’s Neurology, 12th edition, p942

( ) 91. About periodic lateralized epileptiform discharges (PLEDs), which of the

following is CORRECT?

A. Presence of PLEDs indicates an acute destructive cerebral lesion.

B. Acute cerebral infarction, mass lesions and cerebral abscess are the main

causes.

C. Presence of PLEDs is associated with seizures, obtundation, and focal

neurologic signs.

D. PLEDs sometimes appear in patients with chronic structural lesions during

periods of metabolic decompensation.

E. All of above

解答： E 出處： Merrit’s Neurology p-76

( ) 92. About syringomyelia, which of the following is WRONG?

A. The syrinx is most commonly encountered in the mid thoracic region

B. The syrinx is most particularly at the base of the posterior horn, extending

into the central gray matter and anterior commissure.

C. Pain and temperature sensations are typically impaired in the arm on the

involved side.

D. Over two-thirds of cases of syringomyelia are associated with the

Arnold-Chiari type 1 malformation.

E. The syrinx sometimes ascends into the medulla.

解答： (A) 出處：Merritt’s Textbook of Neurology 12th Edition P 551

( ) 93. Which of the following about leukodystrophy is CORRECT?

A. Leukodystrophies are progressive, genetic metabolic disorders causing

demyelination.

B. Classic Pelizaeus-Merzbacher disease was set apart by autosomal recessive,

early-onset, a long course, and the islands of preserved myelin in the

demyelinated area.

C. Patients with globoid cell leukodystrophy are normal at birth and have

decreased nerve conduction velocities.

D. Among varies forms of metachromatic leukodystrophy, juvenile form is the

most common.

E. Adrenoleukodystrophy was set part by involvement of adrenal gland and

X-linked inheritance.

解答： C 出處： Merritt’s Neurology 12th edition p. 621-624

( ) 94. Which of the following is WRONG about classic infantile Tay-Sachs syndrome?

A. Hexosaminidase A deficiency

B. Macular cherry-red spot

C. GM1-gangliosidosis

D. Seizure and myoclonus are prominent for the first 2 years

E. Loss of developmental milestones

解答： C 出處：Merritt’s Neurology 12th edition p. 615-616

( ) 95. Which of the following is WRONG about Lafora disease?

A. Epilepsy

B. Dementia

C. Optic atrophy

D. Onset in adolescence

E. Myoclonus

解答： C 出處：Merritt’s Neurology, 12th edition, p. 633

( ) 96. Which of the following is WRONG about Friedreich ataxia?

A. Autosomal recessive ataxia

B. The age of onset correlates with the longer of the two GAA expanded alleles

C. Absent or hypoactive tendon reflexes and extensor plantar reflexes

D. Proprioceptive and vibratory sensory loss in the legs

E. Approximately two-thirds have cardiomyopathy

解答： B 出處：Merritt’s Neurology, 12th edition, p. 783-784

( ) 97. Which of followings is NOT the cardinal manifestation of Mitochondrial

encephalopathy with lactic acidosis and stroke-like episodes (MELAS)?

A. Diabetes mellitus

B. Exercise intolerance

C. Seizures

D. Onset < 40 years of age

E. Ragged-red fibers

解答： (A) 出處：Neuromuscular disorder in clinical practice, p1159 (2002)

( ) 98. 以下何種藥物並非叢發性頭痛(Cluster headache)的預防性用藥?

A. Verapamil

B. Lithium

C. Topiramate

D. Octreotide

E. Ergotamine

解答： D 出處：Acta Neurol Taiwan 2011;20:213-227

( ) 99. For silent brain infarctions (SBI), which description is WRONG

A. SBI are the most common type of sub-cortical and cortical infarction

B. SBI defined as a small, deep cerebral infarction caused by the occlusion of

small penetrating cerebral arteries

C. The presence of SBI may double the risk of subsequent stroke and dementia

D. Different series reported the frequency of MRI defined SBI ranges from 5 to

50%

E. In Taiwan, the frequency of SBI was less than 10% in healthy subjects

解答：    A   

出處：      Acta Neurol Taiwan 2012;21:18‐24       

( ) 100. Regarding case with sporadic cerebellar degeneration,was impressed in Taiwan,

which immune biomarker should be checked and may provide the possible

subclinical gluten sensitivity-related cerebellar degeneration.

A. Deamidated gliadin-IgA

B. Deamidated gliadin-IgG

C. Tissue transglutaminase-IgA

D. Anti-endomysial-IgA

E. Anti-gliadin IgM

解答：{B} 

出處：Acta neurologica Taiwanica 12/2010; 19(4):263‐9 

 

( ) 101. About the characteristics of neurofibromatosis, which of the following is

WRONG?

A. Six or more café au lait spots larger than 15 mm in diameter after puberty are

diagnostic.

B. Pigmented iris hamartomas are pathognomonic.

C. During pregnancy, women with NF-1 may experience an increase in the

number and size of neurofibromas.

D. Vascular plexiform neurofibromas that result in segmental atrophy of a limb .

E. Neurofibromas involving the peripheral nerves

解答： (D) 出處：Merritt’s Textbook of Neurology 12th Edition P 694-695

( ) 102. Which statement is TRUE for primary CNS and PNS lymphoma?

A. T-cell lymphomas of nervous system are common.

B. Tumor seldom recurs after treatment with cranial irradiation and

corticosteroids

C. A purely meningeal form can involve cranial and peripheral nerves.

D. Neurolymphomatosis present with painful, predominatly sensory affection..

E. MRI with homogeneous enhancement is rare in primary cerebral lymphoma.

解答： C

出處：Adams and Vicotr’s Principles of Neurology 9 e/d P. 630

( ) 103. Which of the following statements is WRONG about pituitary gland tumor

A. Adenomas grow slowly in older patients than younger patients

B. Pleomorphism and mitotic figures are sufficient histologic features to justify

the diagnosis of carcinoma

C. Locally invasive pituitary adenoma are nearly always histologically benign

D. Infundibulomas are rare tumors and are variants of pilocytic astrocytomas

E. Radiation therapy is not routinely administered after gross total resection

解答： B 出處： Merritt's Neurology 12th Edition P.419

( ) 104. Which of the following about childhood brain tumor is WRONG?

A. Astrocytomas are the largest group, mostly of low-grade histology.

B. Medulloblastomas is the most frequent high-grade malignant tumor.

C. Classification as benign or malignant does not reflect clinical behavior of

tumor.

D. Desmoplastic medulloblastoma has a unique nodular histology and worse

outcome, while large cell medulloblastoma has better outcome.

E. Cerebellar astrocytomas arise in the cerebellar hemisphere, while

medulloblastoma involves cerebellar vermis.

解答： D 出處： Merritt’s Neurology 12th edition p. 426-440

( ) 105. Which of the following statement is TRUE about ependymomas?

A. Histologically, characterized by perivascular rosettes or Homer-Wright

rossettes

B. Associated with loss of Chromosome 22, particularly 22q

C. Better prognosis is determined by young age, supratentorial location,

low-grade histology

D. Accounting for 5% of childhood intracranial neoplasms

E. The most common site is the lateral ventricles

解答： B 出處：Merritt’s neuology 12th Ed, p.401

( ) 106. Concerning Japanese encephalitis, which of following statements is WRONG?

A. The disease is most common in elderly, and the mortality rate in some

epidemics has been as high as 50%

B. The causative agent is a mosquito-transmitted flavivirus

C. Seizures, focal neurologic deficits, and movement disorders are common

manifestations

D. Dystonia and parkinsonian features are the common movement disorders

E. The diagnosis may be established by cerebrospinal fluid and serum antibody

解答： A 出處：Merrit’s Neurology, 12th edition, p164

( ) 107. Positive rate of CSF 14-3-3 protein in the following prion disease:

1. sCJD (sporadic Creutzfeldt-Jakob disease)

2. nvCJD (new variant Creutzfeldt-Jakob disease)

3. GSS(Gerstmann-Sträussler syndrome)

4. FFI (fatal familial insomnia)

A. 1>2>3>4

B. 1>4>3>2

C. 1>2>4>3

D. 1>3>4>2

E. 1>4>3=2

解答： C 出處：Merritt's Neurology, 12th Edition, P244~246.

( ) 108. Which one is WRONG about TB meningoencephalitis?

A. Positivity of TB culture is specific in diagnosis of TB

B. Hyponatremia is common

C. Resided among poor hygiene or overcrowding

D. Inflammatory meningeal transudation

E. Basal enhancement on brain MRI

解答： D

出處：Merritt’s Neurology, 12th edition, p129-132

( ) 109. A 33-year-old man, presented with acute lower extremity weakness and urinary

incontinence approximately 2 weeks after a viral illness. Which of the following

is the best therapy of this condition?

A. Interferon beta 1b

B. Intravenous immunoglobulin therapy

C. Plasma exchange

D. Corticosteroid therapy

E. Amantadine

解答：D 出處: Adams Principles of Neurology, 9th ed, p 898-9

( ) 110. Which is the MOST common fungal infection affecting the nervous system?

A. Cryptococcus neoformas

B. Coccidioides immitus

C. Aspergillus

D. Candida

E. Histoplasm

解答： A 出處： Merrit’s 12th edition, 2010 p. 209-210

( ) 111. Which one of the followings is WRONG about Mollaret meningitis?

A. Both sexes are equally affected

B. Detection of herpes simplex type II by PCR is reported

C. During the attack, CSF pleocytosis and slight elevation of the protein

content may be seen

D. Fever with meningeal irritation is present.

E. Early intravenous acyclovir administration significantly reduces the clinical

course and prevents future recurrence.

解答： E 出處：Merritt’s Neurology, 12th edition, page 143