Department of Medicine

ANNUAL REPORT

July 1, 2020 – June 30, 2021

Submitted by:

Polly E. Parsons, MD

E.L. Amidon Chair and Professor Department of Medicine

Date: November 22, 2021

TABLE OF CONTENTS

Section Chair’s Executive Summary ......................................................................................................................3 Department of Medicine Standing Committees .......................................................................................5 Medical Service – UVMMC Practice Sites ...............................................................................................14 Graduate Medical Education.................................................................................................................. 18 Cardiovascular Division.......................................................................................................................... 29 Dermatology Division.............................................................................................................................. 50 Endocrinology Division ............................................................................................................................56 Gastroenterology & Hepatology Division............................................................................................... 69 General Internal Medicine ...................................................................................................................... 76 Geriatric Medicine Division...................................................................................................................... 88 Hematology/Oncology Division................................................................................................................ 91 Hospital Medicine Division..................................................................................................................... 123 Immunobiology Division ........................................................................................................................ 132 Infectious Diseases Division ................................................................................................................... 143 Nephrology Division................................................................................................................................ 158 Pulmonary and Critical Care Medicine Division ..................................................................................... 167 Rheumatology and Clinical Immunology Division................................................................................... 202 Research Funding................................................................................................................................... 208 Awards Details………………………………………………………………………………………………………………………………….…210 Application Summary Data……………………………………………………………………………………………………………….…214 Application Detail Data……………………………………………………………………………………………………………………….215

Department of Medicine Annual Report 2020-2021

Chair’s Executive Summary Last year I started this summary with: The Department of Medicine had another incredible and challenging year: We faced the COVID epidemic and the challenges it brought to all aspects of our lives. The creativity, resilience and commitment of the entire department as we continue to face the challenge is truly remarkable. And this year was another incredible and challenging year highlighted not only by the ongoing pandemic but a devastating cyberattack last fall. Once again the entire department faced the challenges and continued to contribute to outstanding clinical care, education and research. It is truly a privilege to be a part of this team.

Despite the challenges, the stress in every aspect of our lives, and the overwhelming fatigue, there are many achievements and awards to celebrate. We have maintained our strong focus on providing outstanding clinical care even as clinical need in both in the outpatient and inpatient setting exceeds previous levels. To support patient access and care we welcomed 11 faculty over the past year (July 1, 2020 - June 30, 2021) with an additional 5 faculty already hired to start late in 2022. These faculty have joined the divisions of General internal Medicine, Gastroenterology, Cardiology, ID, Hematology, Immunobiology, Rheumatology, Nephrology, and Hospital Medicine and are working not only at UVMMC but also in our network affiliate sites. Last year when the pandemic hit, telemedicine was rapidly incorporated into practice to provide care and we have continued to support our patients with telemedicine when we could reduce the burden of travel and increase access to care. Two faculty were recognized with the Distinguished Clinician Awards for the Department of Medicine: Dr. Eric Ganguly and Dr. Kim Dittus and Dr. Preetika Muthurkrishnan received the Quality Scholarship Award. Education is a core mission for the department. Faculty continue to teach and mentor in innovative new programs at UVM as well as at our affiliate sites. With constraints imposed by the pandemic we welcomed more medical students into our clinics and our inpatient services at UVMMC than ever before. Faculty embraced the challenge and provided excellent clinical experiences. In recognition of their substantial contributions to education, Dr. Andrew Hale received the Foundation Course Director Award, Dr. Julian Sprague was named the UVMHNMG GME Educator of the Year, Dr. Andrew Hale received the UVMHNMG Education Scholarship Award and Dr. Devika Singh received the Gold Humanism Honor Society-Leonard Tow Humanism in Medicine Faculty Award. The Department E. L . Amidon recipient was Dr. Sheila Reddy, and the Mark A. Levine MD Award recipient was Dr. Caleb Burr. Three faculty were inducted in the LCOM Teaching

Academy as members: Dr. Matthew Gilbert, Dr. Shea Lambirth and Dr. Rachel McEntee and Dr. Halle Sobel received the highest level of recognition from the academy, Distinguished Educator. The Department continues to be a nationally/internationally recognized leader in research with contributions to new scientific knowledge. The breadth and depth of research throughout our divisions continues to be a testament to our talented investigators. Key grant awards include: Dr. Devika Singh’s project “Long Term Sequelae Study of COVID-19”, Dr. Mary Cushman’s (Co-PI) COBRE, “Vermont Center for Cardiovascular and Brain Health”, Dr. Neil Zakai’s project “Understanding Risk Factors and Burden of COVID-19 Related Thrombosis and or Bleeding Complications” and Dr. Jason Botten’s project “To discover antibodies that target and neutralize Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)” and Dr. Matthew Kinsey’s project “A Phase I Trial of Intratumoral Cisplatin for Early Stage, Resectable, Non-Small Cell Lung Cancer”. The total research funding for the department hit a new record this year. In recognition of their contributions to research, Dr. Anne Dixon was named the LCOM Research Laureate, Dr. Jason Botten received the Dean’s Mid-Career Investigator Award, Dr. Daniel Weiss received the Dean’s Award for Research Mentorship; Dr. Katharine Cheung was named the UVMHNMG Junior Researcher of the Year, and Dr. Devika Singh was awarded the UVMHNMG Innovation Research Grant. In aggregate, members of the department including students, residents, fellows (MD and PhD) published in high impact journals, as detailed within this report. They were asked to lead and serve on NIH study sections, advisory councils, FDA review panels, and editorial boards. They were invited from around the world to present at scientific meetings (virtually) and to be visiting professors, and they were elected to leadership in national societies. They also received significant recognition from their national and international colleagues: Dr. Josh Farkas- national Championship in Humanism award, Dr. Jason Bates-American Thoracic Society (ATS) Recognition for Scientific Accomplishment, Dr. David Kaminsky ATS Robert Crapo Memorial Lifetime Achievement Award in Pulmonary Diagnostics, Dr. Polly Parsons-Trudeau Medal, and Dr. Mary Cushman-American Heart Association Award of Meritorious Achievement. For their overall contributions, Dr. Kristin Pierce received the Dean’s Faculty Award for Professionalism, Mary Claire Walsh received the Dean’s Staff Award for Professionalism, Dr. Jan Carney received the UVM Citizenship and Service Award, and Dr. Mary Cushman was recognized with the LCOM Gender Equity Outstanding Achievement award. It is impossible to list all of the significant contributions of all of our faculty, trainees, students and staff but they can be found throughout this report. Without the incredible dedication, expertise and excellence of our entire department we could not succeed.

Department of Medicine Standing Committees

Medicine Credentials Committee Members: Glenn Goldman, M.D. Committee Chair Joel Schnure, M.D. David Schneider, M.D. Charlotte Teneback, M.D. Bonita Libman, M.D. Sheela Reddy, M.D. Richard Solomon, M.D. Sadie Mills, M.D. Mark Lazarovich, M.D. Committee Mission: The mission of the Medicine Credentials committee is two-fold. First, the committee is charged with maintaining an up to date policy and procedure / rules and regulations for the Medicine Health Care Service. Second, the committee is charged with ensuring that faculty receive appropriate initial and ongoing performance evaluations to assist the medical staff office with credentialing. Quality Assurance Committee – Cardiac Catheterization Laboratory Members: Prospero Gogo, Committee Chair Harold Dauerman, M.D. Edward Terrien, M.D Karen McKenny, R.N. Rony Lahoud, M.D Committee Mission: The purpose of the committee is to ensure high quality in the processes of care of the cath lab to ensure excellent outcomes. Some goals are to eliminate outliers, reduce variation, and enhance performance. The QA monthly meeting provides rapid turnover feedback mechanisms. The committee is committed to educational opportunities for the staff and incorporating practice standards and guidelines into the laboratory operation. Internal, regional, and national comparative data is included that address cognitive knowledge, procedural skill, clinical judgment, and procedural outcomes.

Fellowship Directors Education Committee Members: M. Pasanen, Committee Chair G. Garrison F. Keating N. Ferrentino M. Gilbert B. Libman K. Pierce J. Sprague D. Correa Committee Mission: The primary mission of the Fellowship Directors’ Education Committee is to provide a forum and improve the training, education and overall experience for all Fellows throughout the UVMMC and to support, and develop the potential of each Fellow; in doing so, the Fellows will become an asset to the medical community providing outstanding care and contributions. Resident Research Committee Members: A. Kennedy, Chair K. Cheung D. Kaminsky C. Lyon M. Pasanen R. Pinckney J. Sprague D. Weiss N. Zakai Committee Mission: Responsibilities of the Committee are, in general, to provide guidance and resources for residents and fellows, along with their mentors, performing scholarly research projects. More specifically, the Committee has the following duties: 1) Explain the research project process to new R2s at their annual R2 retreat in July 2) Conduct R2 Research Evenings every fall, where each R2 and their mentor present their project to the Committee to ensure feasibility and receive any pertinent advice/feedback 3) Review residents’ proposals for travel to national meetings to present abstracts that have been accepted, so that limited travel funds can be awarded 4) Serve on a discussion panel for medical students interested in research 5) Review R3 and fellow abstracts every spring to select the abstracts that will be presented orally and via poster on Resident Research Day and Fellow Research Day 6) Select winners of the R3 research (Harriet Dustan) and mentor awards annually for presentation at the resident graduation dinner

Clinical Competency Committee Members: Halle Sobel, M.D. Committee Chair Jason Bartsch, M.D. Ryan Clouser, D.O. Christine Farnham Eric Ganguly, M.D. Frederike Keating, M.D. Mark Pasanen, M.D. Andrew Hale, M.D Val Cherry Benjamin Depo, M.D. Kevin Qin, M.D. Matt Gervais, M.D. Committee Mission: The mission of the Clinical Competency Committee is to ensure that the graduates of our training program have the necessary knowledge, skills and attitudes to provide excellent patient care and to promote quality and improvement in the health care system. The Clinical Competency Committee meets a minimum of twice yearly to assess resident progress towards independent practice using the Milestones as a platform. This committee is responsible for issues pertaining to resident promotion, remediation and dismissal. The committee is also responsible for preparing a complete summative evaluation report, based on a review of all available evaluations, for each resident semi-annually. Housestaff Selection Committee Members: S. Eldakar-Hein, Chair M. Antkowiak J. Bartsch F. Foerg E. Ganguly G. Garrison M. Gilbert S. Grant A. Hale W. Hopkins D. Kaminsky C. Lyon R. McEntee P. Menon C. Noyes M. Pasanen K. Pierce D. Rand A. Repp L. Smith

H. Sobel A. Teleron J. Winget Committee Mission: The Housestaff Selection Committee is responsible for the recruitment of Internal Medicine Residents. This includes a careful review of applications from candidates, interviews of the invited candidates and, finally the compilation of the rank list for Match Day. As we receive over 1300 applications for residency, and interview over 200 applicants, this committee serves a critical role in the success of the residency. Program Evaluation Committee Members: M. Pasanen, MD - Chair J. Powelson E. Wahlberg K. Wahlberg S. Wayne A. Kumar B. Rigby Sundas Khan B. Depo D. Correa De Sa E. Strout S. Eldakar-Hein A. Hale E. Riser M. Barry J. Bartsch E. Ganguly R. McEntee H. Sobel K. Parker (Program Admin) C. Farnham (Program Admin) Committee Mission: The Program Evaluation Committee meets 1–2 times per month. This committee actively participates in planning, developing, implementing and evaluating all educational activities of the program. This includes reviewing and making recommendations for revision of competency-based curriculum goals and objectives. It also includes addressing areas of noncompliance with ACGME standards and reviewing the program annually using the evaluations of faculty, residents and others. This culminates in an annual report, which summarizes a systematic evaluation of the curriculum and renders the official written Annual Program Evaluation.

Quality Assurance Committee – Medicine Health Care Service Members: Allen Repp, MD Committee Chair Allen Mead Pam Stevens, RN Amanda Kennedy Bradley Tompkins, MPH, MS Stephen DeVoe, MPH, MS Peter VanBuren, MD Julie Lin, MD Juan Pablo Perdomo Rodriguez Richard Zubarik, MD Marie Sandoval, MD Farrah Khan, MD Mark Pasanen, MD Timothy Whitman, DO Jeffrey Rimmer, MD Gil Allen, MD Scott Legunn, MD Lee-Anna Burgess, MD Maria Airoldi, RPh Tammy Berrings, RN Susan Bellemare, RN Peg Gagne, RN Committee Mission: The Medicine QA&I Committee has a broad range of activities:

• Evaluates performance of department on internal, institutional, and regulatory standards • Assists in developing and coordinating new quality initiatives and metrics for the department • Conducts adverse event, mortality, and case reviews • Provides forum for sharing information about QI and patient safety activities across divisions • Reviews and adjudicates High Value Care Project proposals

Faculty Engagement Committee Members: Jennifer Kelly, Chair Katherine Cheung, Nephrology Farrah Khan, Hematology/Oncology Marta Kokoszynska, Pulmonary Alana Nevares, Rheumatology Cindy Noyes, Infectious Disease Joseph Pierson, Dermatology Sheela Reddy, Gastroenterology Marie Sandoval, General Internal Medicine Tina Thornton, Immunobiology

Magdalena Zeglin, Cardiology Amelia Gennari, Geriatrics Committee Mission: We are tasked with facilitating interaction between the different divisions in Medicine. We sponsor gatherings at different times of the year and encourage meeting events between divisions. Our goal is to “open up” the department, to encourage inter divisional discourse, and promote mentorship. Medical Grand Rounds Education Program Committee Members: R. Budd, MD C. Irvin T. Jetton S. Lidofsky M. Wood M. Takla B. Everett L. Burgess S. Lidofsky Committee Mission: The Grand Rounds Committee reviews the format for Grand Rounds and its speakers to insure that it is scientifically sound, presenting up-to-date information, and assisting the medical residents and medical students in becoming familiar with the research going in within the Department. We also review candidates nominated for the Tisdale Lectureship. Scientific Integrity Committee Members: R. Budd, Chair C. Irvin Committee Mission: Scientific Integrity Committee advises the Chair on issues related to policies for reviewing possible scientific fraud. Department of Medicine Faculty Development Committee Members: Joseph Pierson, MD Maura Barry, MD Narandra Bethina, MD Jason Bartsch, MD

Jason Botten, PhD LeeAnna Burgess, MD Nicholas Ferrentino, MD Garth Garrison, MD Farrah Khan, MD Rony Lahoud, MD John Miller, MD Kristen Pierce, MD JuanPablo Perdomo-Rodriguez, MD Marios Prikis, MD Christine Weinberger, MD Zail Berry, MD Committee Mission: The Faculty Development Committee is composed of 1-2 faculty from each division in the Department of Medicine and meets monthly. The charge of the committee is to work with the Vice Chair for Academic Affairs on matters related to faculty development, including faculty mentoring, career development, and promotion. The committee serves as a forum for junior and mid-level faculty to discuss faculty development within the DOM and to foster new initiatives to support the DOM faculty. Current efforts include the development and dissemination of:

• Faculty mentoring and career development support tools • Promotion dossier (Green Sheet) guidance and a standardized Larner College of Medicine CV format • Metrics and guidelines for career development and promotion within the Clinical Scholar Pathway • Mechanisms to recognize and address faculty wellness • The Quarterly Faculty Development newsletter for the DOM

Department of Medicine Reappointment, Promotions, and Tenure Committee The Reappointment, Promotions, and Tenure Committee is composed of three subcommittees: The Tenure Pathway and Promotions Subcommittee, The Clinical Scholar Evaluation and Reappointment Subcommittee, and The Volunteer Pathway Reappointment Subcommittee. Each are composed of selected faculty from the divisions of the Department of Medicine. All three subcommittees participate in the Spring RPT cycle which addresses faculty reappointments, while theTenure Pathway subcommittee also meets for the Fall RPT cycle as well to evaluate faculty going up for promotion. Tenure Pathway and Promotions Subcommittee Members: Jason Bates, PhD Harold Dauerman, MD Christopher Huston, MD Benjamin Littenberg, MD Caroline Lyon, MD Charles Maclean, MD Joseph Pierson, MD

Renee Stapleton, MD, PhD Committee Mission: The mission of the Department of Medicine Tenure Pathway and Promotions Subcommittee is to provide support to the RPT Chair in the preparation of summary information required for reappointment and promotion of Department of Medicine faculty members on the Tenure Track Pathway, and for promotion dossiers of faculty on all promotion tracks. The Committee is charged with reviewing the content of dossiers, assembled by each faculty member under consideration and corresponding unit director, and with writing summaries that highlight accomplishments in the areas of teaching, research and scholarship, and service to the institution and beyond. Each summary will also serve to generate constructive feedback to the faculty member under consideration, so that the goals for future promotion can be achieved. The Subcommittee will meet at least once during the faculty review cycle to finalize the summaries, which will then be forwarded by the Subcommittee Chair to the RPT Committee Chair. Clinical Scholar Evaluation and Reappointment Subcommittee Members: Kristen Pierce, MD Naomi Hodde, MD Internal Medicine Mohit Jindal, MD Internal Medicine Matthew Gilbert, DO Peter Kaufman, MD Chi-Chi Lau, MD Doris Strader, MD Peter Van Buren, MD Timothy Whitman, DO Volunteer Pathway Reappointment Subcommittee Members: Claudia Berger, MD Chair Roberta O'Brien, MD GIM Garth Garrison, MD Pulmonary & Critical Care Medicine Committee Mission: The mission of the Department of Medicine Volunteer Pathway Reappointment Subcommittee is to provide support to the RPT Chair in the preparation of summary information required for reappointment of Department of Medicine faculty members on the Volunteer Pathway. The Committee is charged with reviewing the content of dossiers, assembled by each faculty member under consideration and corresponding unit director, and evaluating eligibility of the faculty member for reappointment on the Volunteer Pathway. The Subcommittee will meet at least once during the faculty review cycle to finalize the recommendations, which will then be forwarded by the Subcommittee Chair to the RPT Committee Chair.

Research Committee Members: Michael Toth, Ph.D. Mary Cushman, M.D., MSc Steven Ades, M.D. Adam Atherly, Ph.D. Ralph Budd, M.D. Melanie Bui, M.D., Ph.D. Katharine Cheung, M.D., Ph.D. Harold Dauerman, M.D. Christopher Huston, M.D. Matthew Poynter, Ph.D. Allen Repp, M.D. Renee Stapleton, M.D., Ph.D. Daniel Weiss, M.D., Ph.D. Michaelanne Rowen, BSN, RN Bridget Carney, CRA Tina Mazuzan Committee Mission: The Department of Medicine’s Research Committee is Chaired by the Vice Chair for Research with faculty representation from each Division/Center and financial/operations leadership staff. The committee meets monthly to discuss a wide range of issues pertaining to the research mission and activities of the department’s faculty. A major focus of the committee is to advise the Chair on decisions that impact the research endeavors of the department’s faculty. Other topics include the development and review policies and procedures relating to research, funding requests, new funding opportunities, changes in Federal policies, dissemination of information and setting new initiatives to enhance the research activities of the department. Quality Assurance Committee – Dermatology Members: T. Holmes, MD G. Goldman, MD C. Weinberger, MD M. Bui, MD A. Fischer, MD K. Morley, MD Committee Mission: Our mission is to ensure quality care and promote continuous quality improvement of services and processes in order to fulfill the needs and expectations of the patients we serve

Medical Service

Ambulatory Care Visits: 205,645 (147,277 specialty care and 58,368 primary care)

Work RVUs: 637,848 work RVUs

UVMMC Practice Sites:

Ambulatory Care Center – Medicine has a presence in five Modules:

• Medicine: Infectious Disease (including Travel Medicine), Rheumatology and Clinical Immunology, Pulmonary (including PFTs), and the Lung Cancer Multidisciplinary Clinic

• Dermatology including Mohs Surgery (occupying two modules)

• Cancer Center: Hematology/Oncology, Breast Care Center and Multidisciplinary Clinic, Vermont Regional Hemophilia Treatment Center, Thrombosis Center

• Surgery: Gastroenterology and Hepatology

University Health Center

• Nephrology

• Sleep Medicine

Tilley Drive, South Burlington

• Cardiology and Cardiac Rehabilitation, Oncology Rehabilitation, Pulmonary Rehabilitation

• Endocrinology, Osteoporosis, and Endocrine Clinical Research

Fanny Allen Hospital

• Memory Clinic

• Vermont Lung Center (Pulmonary Research)

General Internal Medicine:

• Burlington (University Health Center

• South Burlington

• Essex Junction

• Williston

UVMMC Outreach Sites:

Vermont

Brattleboro (BMH) – Infectious Disease

St. Albans (Northwestern Medical Center) –Nephrology, Cardiology

St. Johnsbury (Northeastern Medical Center) - Infectious Disease

Barre (Central Vermont) – Nephrology, Dermatology, Pulmonary, Hem/Onc

Rutland (Rutland Regional) – Nephrology, Cardiology, Infectious Disease

Middlebury (Porter) – Cardiology, Hem/Onc

Newport (Newport Memorial) – Nephrology

New York

Malone (AHMC) - Cardiology

Massena (MMH) – Cardiology

Plattsburgh (CVPH) – Cardiology, Infectious Disease, Dermatology

Nursing Homes and Other Locations:

Elderwood Nursing Facility

The Arbors at Shelburne

Birchwood Terrace Nursing Facility

Green Mountain Nursing Facility

Visiting Nursing Association of Vermont

Castleton Health Center

Community Health Center of Burlington

The Department also participates in many multidisciplinary clinics:

Department of Medicine Multidisciplinary Clinics and Case Conferences/Tumor Boards (examples of participants in parentheses)

Active

• Maternal Fetal Medicine/Gestational Diabetes (Endocrine, Women’s)

• Upper GI MDC and Tumor Board(Gastroenterology, Hematology/Oncology, Rad. Oncology, Pathology, Radiology, Surgery)

• Lung MDC and Tumor Board (Pulmonary, Surgery, Radiation Oncology, Hematology/Oncology, Pathology, Radiology)

• Breast MDC and Tumor Board (Hematology/Oncology, Radiology, Surgery, Radiation Oncology, Pathology)

• Hem Malignancy Conference (Hematology/Oncology, Pathology)

• Brain Tumor Board (Hematology/Oncology, Surgery, Radiology, Radiation Oncology)

• Sarcoma Tumor Board (Hematology/Oncology, Orthopedics, Radiology, Pathology, Radiation Oncology)

• ENT Tumor Board (Hematology/Oncology, Surgery, Radiation Oncology)

• GU MDC and Tumor Board (Hematology/Oncology, Surgery, Pathology)

• Melanoma Tumor Board (Dermatology, Surgery, Hematology/Oncology, Pathology)

• Familial Cancer Program Conference (Genetic counseling, medical oncology, pathology, surgical oncology, ob/gyn).

• Geriatrics/Memory Center (Geriatrics and Neurology)

• Interstitial Lung Disease (Pulmonary and Rheumatology

• Cystic Fibrosis (Pulmonary, Endocrinology, Social Work, Nutritional Services)

• Bone Metabolism (Endocrinology and Rheumatology)

• Stone Clinic (Nephrology and Urology)

• Transplant Clinic (Nephrology and Transplant Surgery)

• Oncology Rehabilitation (Hematology/Oncology, Cardiology, Physical Therapy)

• Pulmonary Rehabilitation (Pulmonary, Cardiology, and Physical Therapy)

• Heart Failure (Cardiology and Primary Care)

• TAVR (Cardiology and Surgery)

• Accredited Stem Cell Transplant Program (Hematology and Pathology/Laboratory)

• Pediatric Hemophelia Clinic (Hematology/Oncology and Pediatrics)

• Telemedicine (Infectious Disease and Brattleboro Memorial Hospital)

Under Development

• Hepatitis C e-consults (Gastroenterology and General Internal Medicine)

Graduate Medical Education Annual Report: 2020-2021 Leadership Mark Pasanen, M.D., FACP – Program Director

Halle Sobel, M.D., FACP – Associate Program Director Andy Hale, M.D. – Associate Program Director (beginning Dec 2020) Prema Menon, M.D. – Associate Program Director (beginning Dec 2020) Christine Farnham, Rosanne Murat, Valarie Cherry – Program Administrators

Summary of Internal Medicine Program Highlights 2020-2021 Enhancements to Curriculum: We continue to refine our approach to our formal education sessions, which now include a noon series 3-4 days/week and academic half-days 2 days/week. For our academic half-day sessions, our residents are split into two cohorts (first-year residents and senior residents), allowing our curriculum to be better targeted at the learner level. In addition, as part of this change, we have encouraged our faculty to continue to work toward more interactive teaching methods. Our academic half-day model has allowed for a more comprehensive curriculum, including robust Improvement Science and Wellness initiatives. Our most recent additions include the launch of a curriculum addressing Equity, Diversity and Inclusion and re-invigoration of our Resident as Teacher curriculum. In addition, over the past 2 years, we have successfully moved Morning Report to Noon Report to allow for increased attendance, and better engagement. Of course, the biggest change of the past year has been the continued need to adapt to on-line learning due to COVID-19 gathering restrictions. After a brief transition period, we were able to successfully transition all of structured teaching to an interactive, tele-education environment and have subsequently moved back to a hybrid system – in which there is a mix of in-person and video participants at our teaching sessions. Board Preparation: We continue to make sure our curriculum is supporting our residents as they prepare for the ABIM certification exam. Our current 3-year pass rate is 91% for first-time takers. We continue to provide MKSAP for all of our residents, and utilize MKSAP questions in many of our teaching sessions. In addition, we provide all residents with subscriptions to NEJM Knowledge (+), a mobile question-based board review product with an adaptive learning interface as part of our commitment to ABIM Board success. Continuity Clinic Update: We continue to take advantage of the block schedule to optimize education. With the leadership of Drs. Halle Sobel and Rich Pinckney at UVMMC and Drs. Jonathan Cohen and Gretchen Gaida-Michaels at the Burlington VA – along with a core of faculty preceptors, residents provide longitudinal care for a diverse population of patients. Twice weekly there are small group learning sessions which continue to be extremely well received by residents – all part of a comprehensive 3-year curriculum. Residents are educated on practice management, population health and continue to complete personal practice improvement projects. In addition, we continue to

incorporate the Yale Ambulatory Curriculum into the formal educational experience, which focuses on common primary care issues. Wellness: Resident wellness has continued to be a priority, especially given the enormous stress of the pandemic. Many of our annual events had to be postponed this past year, as we have only recently have we been permitted to have group gatherings (always in compliance with UVM, UVMMC and Vermont recommendations). In the past, events have included Lake Monsters games, picking apples and making cider, paddle-boarding, paint-and-sip, along with dinners at the Hope Lodge (cooked and served by our residents) – along with other less formal outings. Through the last year, we continued to explore ways to stay connected – and look forward to reestablishing many of our previous events. Improvements in Evaluation/Assessment: With leadership from Dr. Sobel, our robust Clinical Competency Committee reviews all of our residents at least bi-annually, providing milestone-based evaluations and feedback. In addition, this group provides insight and guidance for residents who may benefit from more structured support and/or remediation. Over the last year, a significant amount of work has been done to prepare for the roll-out of Milestones 2.0 – a major change and improvement in residency evaluation requiring a complete overhaul of our evaluations that launched in July 2021. Recruitment: During this past year, we had to adapt to a completely virtual process – and were lucky to have an amazing team of staff and interviewers. We ended up interviewing > 340 applicants, a significant increase as compared to previous years. The increased number of interviewees and reduced barrier of travel necessity allowed us to interview an increasing diverse group of candidates – resulting in a fantastic match (see below for details). Procedural/Ultrasound Training: One of our key priorities over the past several years has been to improve our resident procedural and ultrasound skills. We have initiated an ultrasound elective, and continue to work toward improved technology to store images for faculty review. In addition, we continue to collaborate with colleagues in the Department of Medicine and other departments with the goal of getting our residents opportunities to perform desired procedures. List of All Residents (July 1, 2020-June 30, 2021) PGY-3 Eric Anderson Medical College of Wisconsin Jennifer Bergeron Tufts University School of Medicine Kenyon “KC” Bolton Robert Larner, MD, College of Medicine at the University of Vermont Benjamin Depo State University of New York Upstate Matthew Gervais Pennsylvania State University College of Medicine J. Curtis Gwilliam Robert Larner, MD, College of Medicine at the University of Vermont Sundas Khan Lewis Katz School of Medicine at Temple University

Carrie Mahurin University of North Dakota School of Medicine and Health Sciences Emily McPherson University of New England School of Osteopathic Medicine Jacob Neuwirth University of New England College of Osteopathic Medicine Jacqueline Parker Weill Cornell Medicine Kevin Qin University of Toledo College of Medicine and Life Sciences Samantha Steinmetz-Wood Royal College of Surgeons in Ireland Andrew Wall Albany Medical College Joshua Zimmer Quillen College of Medicine at East Tennessee State University PGY-2 Jason Browne University of Wisconsin School of Medicine and Public Health Nathan Centybear Robert Larner, M.D., College of Medicine at the University of Vermont Elizabeth Carson Robert Larner, M.D., College of Medicine at the University of Vermont Robert Hardwick University of Washington School of Medicine Yu Ting (Christina) He Weill Cornell Medicine Jonathan Hingre State University of New York Upstate Medical Arjun Janardhan Robert Larner, M.D., College of Medicine at the University of Vermont Alison Kim Chicago Medical School at Rosalind Franklin Seth Levy Jacobs School of Medicine and Biomedical Sciences Univ of Buffalo Aurasch Moaven University of Maryland School of Medicine Jamie Rowell Medical University of South Carolina College of Medicine David Steinmetz Perelman School of Medicine at the University of Pennsylvania Ryan Thomas Albany Medical College Sean Till Loyola University Chicago Stritch School of Medicine PGY-1 Siddique Akram University of Wisconsin School of Medicine and Public Health Vishwanath Anekonda University of Washington School of Medicine Tanesha Beebe Loyola University Chicago Stritch School of Medicine Maria Bryan - PC University of Minnesota Medical School Brendan Campbell George Washington University School of Medicine and Health Sci Kyle Crooker University of Kansas School of Medicine – Wichita Brendan Ferraro Lewis Katz School of Medicine at Temple University David Jackson University of New England College of Osteopathic Medicine

Ali Jandal University of Wisconsin School of Medicine and Public Health Colton Jensen University of Iowa Roy J. and Lucille A. Carver College of Medicine John Lamb Mercer University School of Medicine – Savannah Eleanor Stedman - PC Robert Larner, M.D., College of Medicine at the University of Vermont Nicholas Tooley Michigan State University College of Human Medicine - Grand Rapids Sarah Wachtel - PC Albany Medical College Danielle Wall Robert Larner, M.D., College of Medicine at the University of Vermont Preliminary Hannah Porter University of Pittsburgh School of Medicine Daniel De Los Santos Robert Larner, M.D., College of Medicine at the University of Vermont Gregory Johnston Robert Larner, M.D., College of Medicine at the University of Vermont Agnes Bacopulos New York Medical College Kristin Bartman Central Michigan University COM Kaley Kinnamon University of Kansas School of Medicine Lauren Skogsholm University of Connecticut School of Medicine Preliminary Anesthesia shared with Surgery Jack Chan Albany Medical College Jason Dixon University of Connecticut School of Medicine Edwin “Taylor” Haring University of Oklahoma College of Medicine Brett Heber Kansas City Univ of Medicine & Bioscience Coll of Osteopathic Med Britta Kilgus Robert Larner, M.D., College of Medicine at the University of Vermont Matthew “Matt” Nowland Frank H. Netter, M.D. School of Medicine at Quinnipiac University Chief Medical Resident Benjamin Irvine University of Wisconsin School of Medicine and Public Health Shawn Wayne University of Wisconsin School of Medicine and Public Health Edwin Goncharuk University of New England College of Osteopathic Medicine

Resident and Faculty Awards (announced June 2021)

The Harriet P. Dustan, M.D. Award: • Sundas Khan, MD

The Frank L. Babbott, M.D. Memorial Award: • Kenyon “KC” Bolton, MD

Richard E. Bouchard, M.D. Excellence in Primary Care Award: • Kenyon “KC” Bolton, MD

E.L. Amidon, M.D. Award Outstanding Teacher of the Year Subspecialty Medicine: • Sheela Reddy, MD

Mark A. Levine, M.D. Award Outstanding Teacher of the Year General Internal Medicine: • Caleb Burr, MD

Resident Research Day: May 28, 2021 Oral Presentations:

Potential Germline Findings Identified During Somatic Tumor Testing: Room for Improvement Sundas Khan, MD Navigating the Debate on Large (≥4cm) Thyroid Nodules: Local Insight on a Persisting Problem Samantha Steinmetz-Wood, MD Factors associated with clinical outcomes among critically ill patients transferred from small rural hospitals to a tertiary medical ICU Andrew Wall, MD

Poster Presentations:

Age-Related Cancer Screening in Non-English Speaking Patients in Vermont Primary Care Emily McPherson, DO; John Miller, MD Cardiac Stress Testing Education for Outpatient Internal Medicine Residents Josh Zimmer, MD; Sherrie Khadanga, MD Does IV iron reduce the re-admission rate in iron deficient, anemic patients admitted with heart failure exacerbation? Eric Anderson, MD; Bradley Tompkins, MPH, MS; William Hopkins, MD

The Effect of Seasonal Change and Access to Indoor Exercise Facilities on the RAPID3 Index Jacob Neuwirth, DO; Levi N. Bonnell, MPH; Bradley J. Tompkins, MS, MPH; Amanda G. Kennedy, PharmD, BCPS; Chi Chi Lau, MD Evaluating the Quality of Clinical Telephone Updates Matthew Gervais, MD; Ashlynn Ruleman, Amanda G. Kennedy, PharmD, BCPS; Jeanne Shea, PhD Hospital Cardiopulmonary Arrest Patient Outcomes Measured Before and After Initiation of a Resident “Mock Code Blue” Curriculum: An Analysis of ACLS Team Leadership Simulation Effectiveness on Inpatient Cardiopulmonary Arrest Mortality and Adherence to AHA Guidelines at the University of Vermont Medical Center (UVMMC) Carrie Mahurin, MD; Jamie Rowell, MD; Elena Kozakewich, MD; Brennan Rigby, MD; Amy Lynn Teleron, MD, FACP A Pathway for Optimizing Post-Splenectomy Care Benjamin Depo, MD, Sundas Khan, MD*, Jean Dejace, MD, Laura Catoe, NP, Timothy Whitman, DO, Bradley Thompson, Carlos Marroquin, MD, Jennifer Gratton, RN, Ajai Malhrota, MD, Andrew Hale, MD *Denotes co-first authors Patient Experience on a Hospital Oncology Service Before and After Implementation of a No-visitor Policy During COVID-19 Kenyon C. Bolton, MD, MA; Michael Lawler, BS; Jennifer Hauptman, MSW, LICSW; Marissa Madden, RN; Stephen G. DeVoe, MPH, MS; Amanda G. Kennedy, PharmD, BCPS; Bradley Tomkins MPH, MS; Naomi M. Hodde, MD Practice Patterns of Mortality Risk Prediction Tools in the Vermont Dialysis Population Jennifer Bergeron, MD; Christina Damon, MS2; Sean Meagher, MD; Katharine Cheung, MD, PHD Utilization of genetic testing among cancer patients by oncologists in Northern New England Kevin Qin, MD, MSc; Ya Tuo, MSc; Bernard F. Cole, PhD; YongLi Ji, MD, PhD; Jens Reuter, MD; Susan Miesfeldt, MD; Marie Wood, MD Validating the of Use of sGaw in Methacholine Challenge Testing to Diagnose Asthma Jacqueline N. Parker, MD, Allison Tzeng; David Kaminsky, MD

Fellow Research Day: June 4, 2021 Oral Presentations:

Decade Long Temporal Trends in Revascularization for Patients with Diabetes Mellitus: A Report from the Northern New England Cardiovascular Disease Study Group

Jan H. Denkmann, MD, David J. Malenka, MD, Niveditta Ramkumar, MPH, PhD, Cathy S. Ross, MS, Michael N. Young, MD, Samip Vasaiwal, MD, MSC, James M. Flynn, MD, and Harold L. Dauerman, MD* Reducing Rates of Biliary Stent-Associated Cholangitis in Malignant Biliary Obstruction Using a Serologic Algorithm Brendan Everett, MD, and Richard Zubarik*, MD Lower Heart Rates and Beta-Blockers are Associated with New-Onset Atrial Fibrillation Nicole Habel, MD, Jeanne du Faye de Lavallaz, MD, Jodi L. Koehler, MS, Paul D. Ziegler MS, Margaret Infeld, MD MS, Daniel L. Lustgarten, MD PhD and Markus Meyer, MD PhD

Poster Presentations:

A Point Prevalence Analysis within a Longitudinal Serosurvey of COVID-19 in a Vermont School District Sean Bullis MD, Benjamin Grebber, Sally Cook, Sean A. Diehl, Nancy R. Graham, Marya Carmolli, Dorothy Dickson, Beth Kirkpatrick MD, Benjamin Lee, MD Functional significance of 8-isoprostane in sinonasal disease and asthma Brittany Duchene, MD, Sarah Caffry, BS, David A Kaminsky, MD, Loretta G Que, MD, Matthew E Poynter, PhD, Anne E Dixon, MD Endobronchial Ultrasound-Transbronchial Needle Injection Cisplatin Alters Tumor Cellular Composition in Non-Small Cell Lung Cancer Emily DuComb, DO, Delores Cupak, Cheryl Collins MS, Ralph Budd MD, and C. Matthew Kinsey MD, MPH “Immune-Brain”: A case series of cognitive dysfunction in cancer patients on checkpoint inhibitors Sarah Gillett MD, PhD, Ximena Jordan-Bruno, MD, Hibba Rehman, MD, Alissa Thomas, MD Long-term Bachman’s bundle region and His bundle Pacemaker Lead Thresholds Jonathan Halevy, MD, Benjamin Depo, MD, Bradley Tompkins, MPH, MS, Daniel Lustgarten, MD, PhD A Standardized Protocol Improves Testing Rates for Helicobacter Pylori among Inpatients with Peptic Ulcer Disease Jason D. Heffley, MD, MPH, Richard Zubarik, MD Post Discharge Risk of Venous Thromboembolism in a Primary Care Population Ximena Jordan-Bruno, MD, Insu Koh, PhD, Pamela L Lutsey, PhD, Bob Walker, MPH, Nicholas Roetker, PhD, Nicholas L Smith, PhD, Timothy B Plante, MD, MHS, Allen B Repp, MD, Chris E. Holmes, MD, PhD, Mary Cushman, MD, MSc, Neil A. Zakai, MD, MSc

Acute Kidney Injury and Renin Angiotensin System Inhibition Following Transcatheter Aortic Valve Replacement Newton Phuong, MD, Richard J. Solomon, MD; Michael J.DeSarno, MS; Martin M. LeWinter, MD; Joshua Zimmer, MD; Harold L. Dauerman, MD Inappropriate Thyroid Uptake and Scan Testing in Adult Patients with Grave’s Disease-suspected Hyperthyroidism Amy Shah, DO, MPH; Kaitlyn Barrett, DO; Matthew Gilbert, DO, MPH; Amanda Kennedy, PharmD; radley Tompkins Department of Medicine Resident National Meeting Presentations:

Department of Medicine Quality Showcase May 2021:

Testing for Urinary Tract Infection in Adults without Urinary Symptoms: A High Value Care Case Analysis Residents: Eric Anderson, MD; Jennifer Bergeron, MD; Kenyon “KC” Bolton, MD; Benjamin Depo, MD; Matthew Gervais, MD; J. Curtis Gwilliam, MD; Sundas Khan, MD; Carrie Mahurin, MD; Emily McPherson, DO; Jacob Neuwirth, MD; Jacqueline Parker, MD; Kevin Qin, MD; Samantha Steinmetz-Wood, MD; Andrew Wall. MD; Joshua Zimmer, MD Faculty: Lee-Anna Burgess, MD; Virginia L. Hood, MBBS, MPH; Allen B. Repp, MD, MSc Standardizing Methods in Culturing Ascitic Fluid: A Project in Quality Improvement Aurasch Moaven, MD; Shawn Wayne, MD; Sheela Reddy, MD Practice Patterns of Mortality Risk Prediction Tools in the Vermont Dialysis Jennifer Bergeron, MD; Christina Damon, MS2; Katharine L. Cheung, MD, PhD

Medication Changes at the Time of Discharge: An Investigation of Patient Understanding Residents: Jason Browne, MD; Elizabeth Carson, MD; Jonathan Hingre, MD; Lloyd Patashnick, MD; Jaime Rowell, MD; David Steinmetz, MD; Sean Till, MD Patient and Family Advisors: Andrea Desautels, Kathy Leahy, Kate Purcell Faculty: Maria Burnett, MD; Preetika Muthukrishnan, MBBS, MSc; Constance van Eeghen, DrPH, MHSA, MBA; Amanda G. Kennedy, PharmD, BCPS Improving Residents’ Understanding of Patients’ Daily Goals Residents: Nathan Centybear, MD; Robert Hardwick, MD; Yu Ting (Christina) He, MD; Arjun Fung-Janardhan, MD; Alison Kim, MD; Seth Levy, MD; Aurasch Moaven, MD; Ryan Thomas, MD Patient and Family Advisors: Andrea Desautels; Kathy Leahy; Kate Purcell Faculty: Maria Burnett, MD; Preetika Muthukrishnan, MBBS, MSc; Constance van Eeghen, DrPH, MHSA, MBA; Amanda G. Kennedy, PharmD, BCPS Minding the Gaps: A Population Health Curriculum for Internal Medicine Residents Halle G. Sobel, MD, Emily K. Hadley-Strout, MD Elizabeth A. Wahlberg, MD

Graduates 2020 Residents – where did they go? Calvin Gilkey Hospitalist, Central Vermont Medical Center Edwin Goncharuk Chief Medical Resident, University of Vermont Medical Center Benjamin Irvine Chief Medical Resident, University of Vermont Medical Center Darren Knox Hospitalist, Gundersen Health System (Wisconsin) Daniel Krakauer Palliative Care Fellow, Ohio State University Medical Center Yao Li Hospitalist, University of Vermont Medical Center Steven O’Neill Hospitalist, Good Samaritan Regional Medical Center Katherine Peterson Fellowship, Infectious Disease, University of Vermont Medical Center Louis-Bassett Porter Hospitalist, Central Vermont Medical Center Elly Riser Hospitalist, University of Vermont Medical Center Brendan Thoms Fellowship, Rheumatology, University of Vermont Medical Center Shawn Wayne Chief Medical Resident, University of Vermont Medical Center Andrew Wilks Fellowship, Hematology/Oncology, University of Massachusetts Christopher Wargo Primary Care, University of Vermont Medical Center/Essex Scott Young Hospitalist, University of Washington Medical Center

2020 Chief Residents Elizabeth Wahlberg Primary Care, University of Vermont Medical Center (Burlington) Kramer Wahlberg Fellowship, Cardiology, University of Vermont Medical Center Julia Powelson Hospitalist, University of Vermont Medical Center MATCH RESULTS - Spring 2021 Categorical Faiz Abu-Jaber Tufts University School of Medicine Robin Alsher Pennsylvania State University College of Medicine Daniel Bailey Jacobs School of Medicine and Biomed Sciences at the Univ of Buffalo Akshee Batra Maulana Azad Medical College Dominique Billngslea University of Washington School of Medicine Charles Forsythe University of Washington School of Medicine Kelsey Maguire University of New England College of Osteopathic Medicine Kristine McLaughlin University of Minnesota Medical School Jordan Morrison-Nozik University of New England College of Osteopathic Medicine Ahmed Raza Allama Iqbal Medical College Chastidy Roldan State University of New York Downstate Medical Center Coll of Med Massoud Saleki University of Washington School of Medicine Sienna Searles Robert Larner, M.D., University of Vermont College of Medicine Deepak Sharma Eastern Virginia Medical School Sudershan Srinivasan Case Western Reserve University School of Medicine Preliminary Cheyenne Hornback University of Oklahoma College of Medicine at Oklahoma City Joy Lowry Robert Larner, M.D., University of Vermont College of Medicine Zachary Zimmer Jacobs School of Medicine and Biomed Sciences at the Univ of Buffalo Ryan Beal Campbell University Jerry M. Wallace School of Osteopathic Medicine Muhannad Seyam Semmelweis University Faculty of Medicine Samae Scott Albany Medical College Karl Heward University of Utah School of Medicine

Preliminary Anesthesia shared with Surgery Javier Blanco University of Pittsburgh School of Medicine Robert Carpenter University of New England College of Osteopathic Medicine Jonathan Gougelet George Washington School of Medicine and Health Sciences Marc Hammond Robert Larner, M.D., University of Vermont College of Medicine Nicole (Nikki) Kosmider Western Univ of Health Sciences Coll of Osteopathic Med of the Pacific Marc Kostrubiak Robert Larner, M.D., University of Vermont College of Medicine Active Grants: Project Title: Increasing the Pipeline of MAT Prescribers: DATA Waiver Training for All Vermont Medical Students at the Larner College of Medicine Organization Name: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE Funding Source: Department of Health and Human Services Substance Abuse and Mental Health Services Administration (SAMHSA) Grant Number: 1H79TI082571-01 FAIN: H79TI082571 Program Director: Halle Sobel MD Project Period: 9/30/19-9/29/22 Grant Amount: $308,619 (all years) PI Halle Sobel MD, Key Personnel: John Brooklyn MD, Sanchit Maruti MD, Leigh Ann Holterman PhD, Jacqueline Drouin MA; Elly Riser MD and Stephen Devoe, MPH, MS Project Title: Vermont Responds: The Development of Interactive, Online Pain Modules for Pain Management in the Face of the Opioid Crisis Organization Name: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE Funding Source: American Association of Medical Colleges (AAMC) Opioid Education Challenge Grant October 1, 2019 – September 30, 2020 The purpose of this grant is to creative on-line pain management modules for clinicians that will be piloted and assessed by the UVM Graduate Medical Education and CME curriculum committees. PI Stephen Berns MD, Co-Investigators: Martha Seagrave RN, Karen Lounsbury PhD, Elly Riser MD Collaborators (Opioid Education Workgroup): Jeremiah Dickerson MD, Sanchit Maruti MD, Halle Sobel MD and Kathryn Huggett PhD

Cardiovascular Division David J. Schneider, MD, Director https://www.uvmhealth.org/medcenter/Pages/Departments-and-Programs/Cardiology.aspx

The 2020-2021 academic year was once again impacted substantially by the COVID-19 pandemic. The cardiovascular division became expert in provid-ing care with telehealth, recruited a fellowship class remotely, and was able to complete the recruitment of a new faculty member.

The Division added a new faculty member, Dr. Lauren Suggs in August

of 2021. Dr. Suggs completed her fellowship training at Thomas Jefferson in Philadelphia. She will be based at Central Vermont Medical Center. She will

participate in clinical care of the University of Vermont Medical Center, as well. An important transition, Dr. Eric Gauthier, an interventional cardiologist at Champlain Valley Physicians Hospi-tal (CVPH) has taken on a leadership role, serving as the Chief of Cardiology at CVPH.

Despite the limitations associated with the COVID-19 pandemic, the division was clinically

very active. While the pressures of the pandemic limited growth of new programs, the division was able to maintain clinical excellence. With the addition of Drs. Barrett and Harhash, we have seen growth in our care of patients with advanced heart failure. We regularly use implanted pulmonary artery pressure monitors (CardioMems) to reduce hospitalization of high-risk patients with heart failure.

Education of the next generation of leaders in cardiovascular care is a core mission of the

cardiovascular division. Recruitment of new trainees was entirely virtual. Our current fellows were pivotal in hosting the virtual visits. To the surprise of many, the virtual interviews were a great success and well received by all. Choosing a fellowship is an important decision that is difficult to make without seeing the location. We were pleased on match day to welcome four outstanding candidates to our program. Important accomplishments of our current fellows in-clude: Dr. Nicole Habel completed her dissertation for a German equivalent of a PhD. Dr. Mar-garet Infeld was awarded the “Clinical Research Award in Honor of Mark Josephson and Hein Wellens” by the Heart Rhythm Society. This award will support a research year focused on the study of electrically targeted Bachmann’s bundle atrial pacing as a non-pharmacologic therapy for atrial fibrillation. Our fellows were co-authors on sevan peer-reviewed manuscripts published during the past academic year. An outstanding class of fellows (Drs. Denkmann, Phuong, Habel, and Messerschmidt) graduated from our program. Drs. Denkmann and Phuong joined our inter-ventional cardiology training program, Dr. Habel joined our electrophysiology training program, and Dr. Messerschmidt will begin practice in South Dakota.

Scholarly activities complete the tripartite mission of the division. Despite limitations im-

posed by the COVID-19 pandemic, clinical and translational research remained active with both investigator-initiated research as well as participation in multicenter clinical trials. The faculty of

the cardiovascular division authored 49 scholarly publications during the past fiscal year. Two fac-ulty received individual honors this year: Dr. Philip A. Ades was awarded the Distinguished Men-tor Award, Department of Medicine. Dr. Harold L. Dauerman was awarded Dean’s Research Award for Clinical Trial Research. Faculty David J. Schneider, MD

Professor of Medicine Director, Cardiovascular Division Medical Director, Cardiovascular Services, University of Vermont Health Network Research and clinical interests thrombosis platelet biology atherosclerosis/ischemic heart disease preventive cardiology

Aderonke Adeniyi, MD Assistant Professor of Medicine Research and clinical interests advanced heart failure pulmonary hypertension

Philip A. Ades, MD

Philip A Ades MD Endowed Professor of Cardiovascular Prevention Director, Cardiac Rehabilitation Research and clinical interests cardiac rehabilitation preventive cardiology ischemic heart disease

Trace C. Barrett, MD

Assistant Professor of Medicine Associate Director, Echocardiography Laboratory Research and clinical interests echocardiography heart failure peri-procedural TEE for structural heart disease

Kevin Carey, MD

Assistant Professor of Medicine Research and clinical interests coronary intervention cardiac catheterization ischemic heart disease

Daniel Correa de Sa, MD Assistant Professor of Medicine Research and clinical interests clinical cardiac electrophysiology catheter ablation pacemaker and ICD implantation

Harold L. Dauerman, MD

Professor of Medicine Network Director, Interventional Cardiology, UVM Health Network Research and clinical interests coronary and structural heart intervention vascular biology, PCI pharmacology systems of care and regional quality improvement programs

Timothy Garrand, MD

Interventional Cardiology Clinical interests ischemic heart disease cardiac catheterization coronary intervention

Eric Gauthier, MD

Assistant Professor of Medicine Medical Director, Cardiovascular Services, University of Vermont Health Network CVPH Director, Cardiovascular Catheterization Laboratory CVPH Clinical interests ischemic heart disease cardiac catheterization coronary intervention

Prospero B. Gogo, MD

Associate Professor of Medicine Director, Cardiovascular Catheterization Laboratory Director Interventional Cardiology Training Program Research and clinical interests cardiac catheterization percutaneous coronary intervention

Tracy Hagerty, MD

Assistant Professor of Medicine Clinical interests general cardiology

syncope pacemaker and defibrillator therapy

Ahmed Harhash, MD

Assistant Professor of Medicine Research and clinical interests advanced heart failure and cardiac transplant cardiac critical care mechanical circulatory support

William E. Hopkins, MD

Attending Cardiologist Director, Adult Congenital Heart Disease Program Clinical interests adult congenital heart disease genetic heart disease valvular heart disease echocardiography

Roger Ishac, MD

Assistant Professor of Medicine Clinical interests ischemic heart disease cardiac catheterization coronary intervention

Friederike Keating, MD

Professor of Medicine and Radiology Director, Nuclear Cardiology and Stress Laboratory Program Director, Cardiovascular Fellowship

Research and Clinical interests multimodality imaging medical education cardiovascular disease in women inpatient general cardiology

Robert J. Kelm, Jr., PhD

Associate Professor of Medicine Associate Professor of Biochemistry Research interests molecular biology of smooth muscle cell and myofibroblast differentiation mechanisms of cardiac and vascular remodeling regulation of smooth muscle gene expression biochemistry of protein-nucleic acid interactions

role of ssDNA/RNA-binding proteins in heart disease and cancer Sherrie Khadanga, MD

Assistant Professor of Medicine Assistant Director, Cardiac Rehabilitation Research and clinical interests cardiac rehabilitation women and cardiovascular disease systolic heart failure

Rony Lahoud, MD

Assistant Professor of Medicine Research and clinical interests cardiac catheterization coronary intervention structural heart disease renal injury and recovery with coronary and structural procedures optimal platelet therapy post coronary intervention

Martin M. LeWinter, MD

Professor Emeritus of Medicine and Molecular Physiology and Biophysics Research and clinical interests heart failure and cardiomyopathies cardiac hypertrophy heart failure with preserved ejection fraction effects of hypertension and diabetes on the myocardium pericardial disease

Robert Lobel, MD

Assistant Professor of Medicine Research and clinical interests clinical cardiac electrophysiology catheter ablation pacemaker and ICD implantation

Daniel Lustgarten, MD

Professor of Medicine Research and clinical interests clinical cardiac electrophysiology catheter ablation pacemaker and ICD implantation His bundle pacing

Richard L. Page, MD

Professor of Medicine

Dean, Robert Larner, M.D. College of Medicine Research and clinical interests sudden cardiac death automated external defibrillators pharmacological therapy for atrial fibrillation

Peter S. Spector, MD

Professor of Medicine Director, Cardiac Electrophysiology Director, Electrophysiology Fellowship Training Program Research and clinical interests catheter ablation atrial fibrillation

Jeffrey L. Spees, PhD

Professor of Medicine Professor of Neurological Sciences Director, Stem Cell Core Facility Research interests adult stem cell biology regenerative medicine repair of cardiac and CNS tissues vascular biology

Edward Terrien, MD

Associate Professor of Medicine Director, Ambulatory Cardiovascular Clinic Research and clinical interests coronary intervention cardiac catheterization peripheral vascular intervention ischemic heart disease

Nathaniel Thompson, MD Assistant Professor of Medicine Research and clinical interests clinical cardiac electrophysiology catheter ablation pacemaker and ICD implantation

Marc D. Tischler, MD

Associate Professor of Medicine Director, Echocardiography Laboratory Co-Director, Cardiac MRI Laboratory

Research and clinical interests magnetic resonance imaging and echocardiography valvular heart disease ischemic heart disease congestive heart failure

Michael J. Toth, PhD

Professor of Medicine Research interests skeletal muscle physiology cardiac rehabilitation aging physical disability muscle disuse

Peter VanBuren, MD

Associate Professor of Medicine Associate Professor of Molecular Physiology and Biophysics Director, Cardiovascular Care Unit Director, Heart Failure Program Associate Director Cardiovascular Training Program Research and clinical interests specialist in heart failure echocardiography nuclear cardiology

Matthew W. Watkins, MD

Professor of Medicine Director of Interventional Cardiology Research and clinical interests interventional cardiology ischemic heart disease

Joseph Winget, MD

Associate Professor of Medicine Research and clinical interests clinical cardiac electrophysiology catheter ablation pacemaker and ICD implantation

Magdalena Zeglin, MD Assistant Professor of Medicine Research and clinical interests coronary artery disease

interventional cardiology Pierre Znojkiewicz, MD Assistant Professor of Medicine Research and clinical interests clinical cardiac electrophysiology catheter ablation pacemaker and ICD implantation

Fellows Jan Denkmann Binnie Desai

Carrie Mahurin Krina Patel

Nicole Habel Newton Phuong Bhisham Harchandani Brennan Rigby Margaret Infeld Toishi Sharma Cecile King Matthew Kluge

Kramer Wahlberg Tyler Wark

Anand Muthu Krishnan Joshua Zimmer Nurse Practitioners and Physician Assistants Cara DiMasi, APRN Ann Laramee, APRN Gregory Ehle, PA Margaret MacDonald, NP Catherine Falduto, APRN Allison Mack, APRN Alison Farr, APRN Cheryl McNeil, APRN Nadia Fletcher, DNP Deborah Moyer, APRN Susan Ann Hamlyn-Prescott, APRN Nancy Strong, APRN Graduate Students, Post-doctoral Fellows, MD PhD Students Philip A. Ades, MD Will Middleton Chair of Master’s Committee for Will Middleton: Association of Psychosocial Factors with At-tendance and Fitness Improvement in Cardiac Rehabilitation Harold L. Dauerman, MD Althea Tapales, LCOM medical student 2nd year, summer research student 2021. Robert J. Kelm, Jr., PhD Andrea Foote, PhD student Martin M. LeWinter, MD Matthew Kluge, MD

Jeffrey L. Spees, PhD John McInnis, Ph.D. Nicholas Toker, M.S. Benjamin Liebman, M.S. Lucy Greetham, B.S. Michael J. Toth, PhD Deena Snoke, PhD, Postdoctoral Fellow Leadership in Professional Societies Prospero B. Gogo, MD Vermont Chapter of the American College of Cardiology, Past Governor ABIM Item Writing Task Force for Interventional Cardiology ABIM Standards-setting for Interventional Cardiology Friederike Keating, MD American College of Cardiology, Governor for VT American College of Cardiology, Chair, Choosing Wisely Workgroup American College of Cardiology, Member, ACC Program Director and GME Steering Council American College of Cardiology, Member, Membership Committee American College of Cardiology, Organizer, Virtual Learning Panel ASNC, Member, Health Policy Council Robert J. Kelm, Jr., PhD UVM Institutional Biosafety Committee, Chair Graduate Studies Committee, Department of Biochemistry, Chair Biochemistry Graduate Program, Director Sherrie Khadanga, MD American Heart Association GPM & EPI Molecular Determinants of Cardiovascular Health Com-mittee of the Council on Genomic and Precision Medicine, Member American Heart Association CLCD Exercise, Cardiac Rehabilitation, and Secondary Prevention Committee of the Council on Clinical Cardiology, Member American Association of Cardiovascular and Pulmonary Rehabilitation Early Career Committee, Member American College of Cardiology Leadership Academy, Member American Association of Cardiovascular and Pulmonary Rehabilitation Research Committee, Member Rony Lahoud, MD American College of Cardiology, Fellow

Society of Cardiac Angiography and Intervention, Fellow, Member of Communications Steering Committee Martin M. LeWinter, MD Council on Clinical Cardiology, American Heart Association, Fellow American College of Cardiology, Fellow Council on Circulation and Basic Cardiovascular Sciences, American Heart Association Association of University Cardiologists, Fellow International Academy of Cardiovascular Sciences, Fellow Daniel Lustgarten, MD Heart Rhythm Society, Fellow American College of Cardiology Political Action Committee, Member Paul Dudley White Society - Cardiology Division, Member Richard L. Page, MD Heart Rhythm Society, Past President Association of Professors of Cardiology, Past President American Clinical and Climatological Association, Councilor Peter S. Spector, MD Heart Rhythm Society, Fellow Matthew W. Watkins, MD Northern New England Cardiovascular Disease Study Group, Executive Board Green Mountain Care Board, Vt. State health care reform program, Advisory Board Green Mountain Care Board, Vt. State health care reform program for specialty practice, Tech-nical Advisory Board

Editorships and Editorial Boards Philip A. Ades, MD Consulting Editor (former Editor-in-Chief): Journal of Cardiopulmonary Rehabilitation and Pre-vention Reviewer: Circulation, JACC, JAMA Cardiology, JACC Heart Failure, Journal of Cardiopulmonary Rehabilitation and Prevention Harold L. Dauerman, MD Associate Editor, Journal of the American College of Cardiology Prospero B. Gogo, MD Reviewer: American Journal of Cardiology and Coronary Disease

Rony Lahoud, MD Editorial Board: Cardiovascular Revascularization Medicine Martin M. LeWinter, MD Section Editor: Myopericardial Disease, Up-To-Date Editorial Boards: Circulation, Heart and Vessels, Experimental and Clinical Cardiology, Current Cardiology Reviews, Heart Failure Reviews Daniel Lustgarten, MD Editorial Board: Journal of Innovations in Cardiac Rhythm Management Richard L. Page, MD Editorial Board: American Heart Journal Section Editor: Cardiac Arrhythmias, Up-To-Date Peter S. Spector, MD Guest Editor: Journal of the American College of Cardiology: Clinical Electrophysiology Marc D. Tischler, MD Ad Hoc Reviewer: American Journal of Cardiology, Journal of American College of Cardiology, Journal of American Society of Echocardiography Michael J. Toth, PhD Editorial Boards: American Journal of Physiology-Endocrinology and Metabolism, Journal of Cel-lular Biochemistry Study Sections, National Advisory Boards, National/International Invited Talks Philip A. Ades, MD DSMB member for MACRO Study, Daniel Forman MD PI, University of Pittsburgh (NIH sup-ported) Harold L. Dauerman, MD Data Safety and Monitoring Board for 5 National trials of renal denervation, percutaneous mi-tral intervention, percutaneous tricuspid intervention and coronary atherectomy Via the Harvard Clinical Research Institute and the Cardiovascular Research Foundation. Friederike Keating, MD American Medical Association, CPT Advisor for the American Society of Nuclear Imaging Sherrie Khadanga, MD Current State of Spontaneous Coronary Artery Dissection (SCAD) Research and Practice in Car-diac Rehabilitation. AACPVR National Meeting Workshop. Sept 30, 2020..

Rony Lahoud, MD Society of Cardiac Angiography and Intervention, Invited Speaker at 2019-2020 Annual Meet-ings Martin M. LeWinter, MD Consultant, Kiniksa Therapeutics Consultant, SOBI Orphan Therapeutics “Acute and Recurrent Pericarditis”, lecture for Kiniksa Therapeutics sponsored conference Richard L. Page, MD FDA Circulatory System Devices Panel, Past-Chair Peter S. Spector, MD Cardiology grand rounds: OUHSC 12/10/2020 “What to do when pulmonary vein isolation fails?”: Rhythm interventions online European con-ference Chair, live cases: Rhythm interventions online Minimising X-rays during AF ablation Chair, live case: Rhythm interventions online Ablation Technology – Live Case Arash Arya, Leip-zig Heart Centre, Leipzig, DE Jeffrey L. Spees, PhD Review panel to select Canadian Research Chairs Ph.D. Thesis Defense Review Panel; Melbourne University, Australia Invited Lecturer, American Epilepsy Society Meeting 2020 Michael J. Toth, PhD National Institutes of Health, ZRG1 F10B-B, Ad hoc National Institutes of Health, ASG, Ad hoc Magdalena Zeglin, MD 2021 International Congress of Electrocardiology- joint meeting of the 21th Congress of the In-ternational Society for Holter and Noninvasive Electrocardiology (ISHNE) and the 48th Congress of the International Society of Electrocardiology (ISE), Zakopane Poland. Topic: Gender disparity in atrial fibrillation. Major Faculty Honors and Awards Philip A. Ades, MD Distinguished Mentor Award, Department of Medicine, 2021 Harold L. Dauerman, MD Dean’s Research Award for Clinical Trial Research, 2021

Jeffrey L. Spees, PhD Samba BioLogics, Inc. selected for UVM/Celdara Medical DRIVEN Program, 2020 US10,632,153 Compositions and Methods of Cardiac Tissue Repair (Inventor), 2020 US10,675,329 Composition comprising Connective Tissue Growth Factor (CTGF) for cardiac tis-sue repair (Inventor), 2020 Grants Philip A. Ades, MD NIH: The National Institute of General Medical Sciences: Vermont Center on Behavior and Health (COBRE Grant). P20GM103644 Role: Associate Director Case Management vs Financial Incentives on Cardiac Rehabilitation Participation in Low SES In-dividuals. R33HL143305 Role: Co-Principal Investigator Harold L. Dauerman, MD TAVR EXPAND trial, National Executive Committee—A comparison of medical therapy versus early TAVR in patients with asymptomatic or moderate aortic stenosis. Sponsor Medtronic. Budget: TBD NO-AKI Pilot Trial: Ultrasound mediated modulation of urinary oxygen and nitric oxide among patients undergoing TAVR (with R. Solomon and R. Lahoud): Funded by Sonogenix, 49,000 dol-lars. ACURATE NEO: A 3rd Generation TAVR valve pivotal trial. Site principal investigator. Sponsored by Boston Scientific—estimated grant funding: 250,000 dollars. Friederike Keating, MD NIH 1U01HL133817-01 Myocardial Ischemia and Transfusion (MINT) Role: Site Principal Investigator Robert J. Kelm, Jr., PhD Atomwise, Inc. AIMS Award A19-363 Identification of Small Molecules Targeting Purine-Rich Element Binding Protein B Role: Principal Investigator UVM Cancer Center Pilot Project 2020 Evaluation of Purine-Rich Element Binding Protein B as a Druggable Target in Cancer Therapy Role: Principal Investigator

Sherrie Khadanga, MD VCBH COBRE P20GM103644 ($250k/year) Role: Project Director CVRI Early Career Grant ($9500) Role: Principal Investigator Rony Lahoud, MD XIENCE 90: A Safety Evaluation of 3-month DAPT After XIENCE Implantation for HBR patients Role: Site Principal Investigator Shockwave Medical, Inc. SHOCKWAVE Coronary Lithoplasty Study (Disrupt CAD II) Role: Site Principal Investigator Martin M. LeWinter, MD NIH RO1 HL118524 Rilonacept Inhibition of Interleukin-1 Alpha and Beta for Recurrent Pericarditis: A Pivotal Symptomatology Inflammatory cytokines in pericardial fluid from patients with pericarditis Daniel L. Lustgarten, MD, PhD Cross X4 15-406: Evaluate the presence of PNS in pts who receive a BSCI device with SJM LV Lead Role: Sub Principal Investigator PSR M09-167: Product Surveillance Registry Role: Sub Principal Investigator Protego DF4 15-353: Determine the effectiveness of Biotronik’s DF4 lead Role: Principal Investigator Quadripolar Pacing Post Approval Study M13-013: Evaluate the acute and chronic performance of a Quadripolar CRT-D device system in a patient population indicated for cardiac resynchroni-zation therapy Role: Principal Investigator TEMPO 15-008: To evaluate the effect of GS-6615 compared to placebo on the overall occur-rence of appropriate ICD interventions (antitachycardia pacing [ATP] or shock) in subjects with ICD or CRT-D during the first 24 weeks of treatment Role: Principal Investigator

MR-HIS 16-244: Retrospective multicenter analysis of His bundle pacing outcomes Role: Principal Investigator HIS Bundle Pacing Registry 00000048: The HBP Registry is a prospective, observational, multi-center registry Role: Principal Investigator Peter S. Spector, MD Epicardial Mapping of Atrial Fibrillation Sponsor: Coremap Role: Sub-Investigator Study CathVision Cube® Monitoring Assessment Sponsor: CathVision Role: Sub-Investigator Jeffrey L. Spees, PhD R01 HL132264 “Vascular protection by HGF/IgG protein complexes that activate RYK“ 4/01/2016-3/31/2021 Role: Principal Investigator GreenSeal Cannabis Company, Ltd. “Cloning of Cannabis biosynthesis enzymes” Role: Principal Investigator Michael J. Toth, PhD NIH R01 AR065826 Skeletal Muscle Atrophy and Dysfunction in Human Cancer Role: Principal Investigator NIH R01 AG050305 Skeletal Muscle Atrophy and Dysfunction Following Total Knee Arthroplasty Role: Principal Investigator NIH R01 HL143452 Effects of exercise on inflammation-induced lung and muscle injury in critical illness (NEXIS-FLAME) Role: Principal Investigator (multi-PI grant) R01 AR0767 The adaptive response of skeletal muscle, bone, and cartilage to severe knee trauma involving ACL disruption with and without concomitant injury to the meniscus

Role: Co-Investigator Matthew W. Watkins, MD Capricor, Inc. Randomized, Double-Blind, Placebo-Controlled Phase I/II Study of the Safety and Efficacy of In-tracoronary Delivery of Allogeneic Cardiosphere-Derived Cells in Patients With an Anterior My-ocardial Infarction and Ischemic Left Ventricular Dysfunction (ALLogeneic Heart STem Cells to Achieve Myocardial Regeneration, ALLSTAR) – Enrollment ongoing Role: Site Principal Investigator NIH/Renova Therapeutics Adenovirus Vector Type 5 (Ad5.hAC60 Expressing Human Adenylyl Cyclase Type 6) Adminis-tered via Intracoronary Catheterization – enrollment completed 2014, study ongoing Role: Site Principal Investigator Joseph Winget, MD AdaptResponse 15-066: Test the AdaptivCRT algorithm in CRT indicated patients Role: Principal Investigator QP Excel 17-0163: Confirm safety and effectiveness of the Sentus QP LV lead and BIOTRONIK CRT-D. Role: Principal Investigator Publications Ades PA, Balady GL, Berra K, Franklin BA, Froelicher V, Hamm LF, Kaminsky LA, Williams MA The Journal of Cardiopulmonary Rehabilitation and Prevention at 40 Years and its role in the Evolution of Cardiac Rehabilitation. J Cardiopulm Rehabil Prev. 2020 40:2-8. PMID: 31868839. Ades PA, Savage PD. The Treatment of Obesity in Cardiac Rehabilitation: A Review and Practical Recommendations. In Press. J Cardiopulm Prev Rehabil. 2021. Anderson, CJ, Phuong NS, Mayhew CR , Dauerman HL, Mitchell H Tsai MH, Martin JA. Retro-spective Single Center Comparison of Transcatheter Aortic Valve Replacement Cost Per Minute Using General Anesthesia Versus Sedation. J. Clin. Anesthesia. 2020; 66: 109957 Barrett K, Savage PD, Ades PA. Effects of Weight Loss Goal Setting in Cardiac Rehabilitation. J Cardiopulm Rehabil Prev. 2020 Nov;40(6):383-387. PMID: 32694455 Bivona JJ, Crymble H, Guigni BA, Stapleton RD, Files DC, Toth MJ, Poynter ME, Suratt BT. Macro-phages augment the skeletal muscle proinflammatory response through TNFα following LPS-induced acute lung injury. FASEB J 35: e21462, 2021. [PMC 7970444]

Bolivar H, Elliot R, Middleton W, Yoon JH, Okoli CTC, Haliwa I, Miller CC, Ades PA, Gaalema DE. Social Smoking Environment and Associations with Cardiac Rehabilitation Attendance. J Cardi-opulm Rehabil Prev. 2020, 41:46-51. . PMID: 32925296 Carrick RT, Benson BE, Bates ORJ, Spector PS. Competitive Drivers of Atrial Fibrillation: The In-terplay Between Focal Drivers and Multiwavelet Reentry. Front Physiol. 2021 Mar 16;12:633643. doi: 10.3389/fphys.2021.633643. PMID: 33796028; PMCID: PMC8007783.

Damp JB, Cullen MW, Soukoulis V, Tam MC, Keating FK, Smith SA, Bhakta D, Abudayyeh I, Qasim A, Sernyak A, Auseon A, Theriot P, Weissman G. Program Directors Survey on Diversity in Cardiovascular Training Programs. J Am Coll Cardiol. 2020 Sep 8;76(10):1215-1222. doi: 10.1016/j.jacc.2020.07.020. PMID: 32883415. Damp JB, Cullen MW, Soukoulis V, Tam MC, Keating FK, Abudayyeh I, Qasim A, Theriot P, Weiss-man G. Parental Leave in Cardiovascular Disease Training Programs. J Am Coll Cardiol. 2020 Jul 21;76(3):348-349. doi: 10.1016/j.jacc.2020.05.044. PMID: 32674798.

Dauerman HL, Ibanez BJ. The Edge of Time in Acute Myocardial Infarction; J Am Coll Cardiol 2021; 77: 1871–1874.

Dauerman HL, Mack MM. International Trends in Coronary Intervention: A Bridge over Rising Coronary Waters. J Am Coll Cardiol 2020;76: 1341-1344.

Dauerman HL. The Unbearable Thrombus of COVID 19. J Am Coll Cardiol, 2020; 76: 1177-1180. Denkmann JH, Malenka D, Ramkumar N, Ross C, Young MN, Vasaiwal S, Flynn Dauerman HL. Decade Long Temporal Trends in Revascularization for Patients with Diabetes Mellitus:A Report from the Northern New England Cardiovascular Disease Study Group. The American Journal of Cardiology, 2021 in press. Dube SL, Sigmon S, Althoff RR, Dittus K, Gaalema DE, Ogden DE, Phillips J, Ades PA, Potter AS (2020): Association of self-reported executive function and mood with executive function task performance across adult populations, Applied Neuropsychology: Adult, epub ahead of print. DOI:10.1080/23279095.2020.1794869 Ferris LA, Foote AT, Wang SX, Kelm RJ Jr. Purine-rich element binding protein B attenuates the coactivator function of myocardin by a novel molecular mechanism of smooth muscle gene re-pression. Mol Cell Biochem doi: 10.1007/s11010-021-04117-1. Epub 2021 Mar 20. PMID: 33743134

Gaalema DE, Bolívar HA, Khadanga S, Priest JS, Higgins ST, Ades PA. Current smoking as a marker of a high-risk behavioral profile after myocardial infarction. Prev Med. 2020 Nov;140:106245. doi: 10.1016/j.ypmed.2020.106245. Epub 2020 Sep 8. PMID: 32910931; PMCID: PMC7680426.

Infeld M, Nicoli CD, Khadanga S, VanBuren P, Correa de Sa DD. Congenital left ventricular wall defects presenting with ventricular arrhythmias: A case series. HeartRhythm Case Rep. 2020 Jul 3;6(10):715-719. doi: 10.1016/j.hrcr.2020.06.026. PMID: 33101939; PMCID: PMC7573374. Kadavath SM, Terrien EF, Ittleman FP, Lahoud R, Phuong NP, Dauerman HL, Rescue of Threatened Coronary Obstruction Due to Sinus Sequestration: Valve-in-Valve Transcatheter Aortic Valve Replacement, JACC: Cardiovascular Interventions, 2021:doi.org/10.1016/j.jcin.2021.02.020.

Keteyian, S, Ades PA, Beatty A, Gavic A, Hines s, Lui K, Schopfer D, Thomas R, Sperling L. A Re-view of the Design and Implementation of a Hybrid Cardiac Rehabilitation Program: An Expand-ing Opportunity for Optimizing Cardiovascular Care. In Press, J Cardiopulm Rehabil Prev, 2021. Khadanga S, Gaalema DE, Savage P, Ades PA. Underutilization of Cardiac Rehabilitation in Women: BARRIERS AND SOLUTIONS. J Cardiopulm Rehabil Prev. 2021 Jul 1;41(4):207-213. doi: 10.1097/HCR.0000000000000629. PMID: 34158454; PMCID: PMC8243714. Khadanga S, Gaalema DE, Savage PD, Ades PA. Women in Cardiac Rehabilitation: A Review In Press, J Cardiopulm Prev and Rehabil, June 2021 Khadanga S, Savage PD, Gaalema DE, Ades PA. Predictors of Cardiac Rehabilitation Participa-tion: OPPORTUNITIES TO INCREASE ENROLLMENT. J Cardiopulm Rehabil Prev. 2021 Jan 25:10.1097/HCR.0000000000000573. doi: 10.1097/HCR.0000000000000573. Epub ahead of print. PMID: 33512979; PMCID: PMC8310538. Kirtane AJ, Mauri L, Windecker S, Yeh RW, Dauerman HL, Price MJ, Christen T, Allocco DJ, Mer-edith IT, Kereiakes DJ. The EVOLVE Short DAPT Study to Assess 3-month Dual Antiplatelet Ther-apy in Subjects at High Risk for Bleeding undergoing Percutaneous Coronary Intervention. Circu-lation Cardiovascular Interventions, 2021: Mar 1:DOI 120010144. Kirtane AJ, Stoler R, Feldman R, Neumann FJ, Boutis L, Tahirkheli N, Toelg R, Othman I, Stein B, Choi JW, Windecker S, Yeh RW, Dauerman HL, Price MJ, Underwood P, Allocco D, Meredith I, Kereiakes DJ. Primary Results of the EVOLVE Short DAPT Study: Evaluation of 3-Month Dual An-tiplatelet Therapy in High Bleeding Risk Patients Treated With a Bioabsorbable Polymer-Coated Everolimus-Eluting Stent. Circ Cardiovasc Interv. 2021 Mar;14(3):e010144. Klein AL, Imazio M, Brucato A, Cremer P, LeWinter M, Abbate A, Lin D, Martini A, Beutler A, Chang S, Fang F, Gervais A, Perrin R, Paolini JF. RHAPSODY: Rationale for and design of a pivotal Phase 3 trial to assess efficacy and safety of rilonacept, an interleukin-1α and interleukin-1β trap, in patients with recurrent pericarditis. Am Heart J. 2020 Oct;228:81-90. doi: 10.1016/j.ahj.2020.07.004.

Klein AL, Imazio M, Cremer P, Brucato A, Abbate A, Fang F, Insalaco A, LeWinter M, Lewis BS, Lin D, Luis SA, Nicholls SJ, Pano A, Wheeler A, Paolini JF, for the RHAPSODY Investigators. Phase 3 trial of interleukin-1 trap Rilonacept in recurrent pericarditis. New Eng J Med. 2020; Nov 16. doi: 10.1056/NEJMoa2027892 Klein AL, Lin D, Cremer PC, Nasir S, Luis SA, Abbate A, Ertel A, LeWinter M, Beutler A, Fang F, Paolini JF. Efficacy and safety of Rilonacept for recurrent pericarditis: Results from a phase 2 clinical trial. Heart. 2020; doi:10.1136/heartjnl 2020-317928. LeWinter M, Kontzias A, Lin D, Cella D, DerSarkissian M, Zhou M, Duh MS, Watson M, Magestro M. Burden of recurrent pericarditis on health-related quality of life. Am J Cardiol. 2020 Nov 19:S0002-9149(20)31244-3. doi: 10.1016. Lahoud RL, Dauerman HL. The Fall and Rise of Coronary Intervention. Journal of the American Heart Association, 2020; 9: e016853. Liebeskind DS, Hinman JD, Kaneko N, Kitajima H, Honda T, De Havenon AH, Feldmann E, Nogueira RG, Prabhakaran S, Romano JG, Callas PW, Schneider DJ. Endothelial Shear Stress and Platelet FcγRIIa Expression in Intracranial Atherosclerotic Disease. Front Neurol. 2021 Feb 25;12:646309. doi: 10.3389/fneur.2021.646309. PMID: 33716947; PMCID: PMC7947292. Lin D, Klein A, Cella D, Beutler A, Fang F, Magestro M, Cremer P, LeWinter MM, Luis SA, Abbate A, Ertel A, Litcher-Kelly L, Klooster B, Paolini JF. Health related quality of life in patients with re-current pericarditis: results from a phase 2 study of rilonacept. BMC Cardiovasc Disord 2021; 21: 201. Published online 2021 Apr Melbostad H, Savage PD, Mahoney K, Gaalema D, Ades PA, Shepard DS. Financial Analysis of Cardiac Rehabilitation and the Impact of COVID-19. In Press, J Cardiopulm Prev Rehabil, 2021. Miao, T., Little, A.C., Aronshtam, A., Marquis, T., Fenn, S.L., Hristova, M., Krementsov, D.N., Vliet, A.V., Spees*, J.L., Oldinski*, R.A. Internalized FGF-2-Loaded Nanoparticles Increase Nu-clear ERK1/2 Content and Result in Lung Cancer Cell Death. Nanomaterials (Basel). 2020 Mar 27;10(4):612. doi: 10.3390/nano10040612. PMID: 32230722; PMCID: PMC7221911. *corre-sponding authors Page RL. The Closing Argument for Surgical Left Atrial Appendage Occlusion. N Engl J Med. 2021 Jun 3;384(22):2154-2155. doi: 10.1056/NEJMe2106069. Epub 2021 May 15. PMID: 33999543. Palmer BM, Swank D, Miller MS, Tanner BCW, Meyer M, LeWinter MM. Enhancingdiastolic function by strain-dependent detachment of cardiac myosin crossbridges. J Gen Physiol. 2020;152: e201912484. Phuong, NS, Solomon RJ, Lewinter MM, Lahoud R, Dauerman, HL. The Incidence and Predictors of Renin-Angiotensin System Inhibition After TAVR, J Inv Cardiology, in press, 2021.

Rao, K.S., Kloppenburg, J.E., Marquis, T., Solomon, L., McElroy-Yaggy, K.L., and Spees, J.L. 2021. CTGF-D4 amplifies LRP6 signaling to promote grafts of adult epicardial-derived cells that im-prove cardiac function after myocardial infarction. Stem Cells (In Press). Rengo JL, Hiroshima F, Leavitt BJ, Ades PA, Toth MJ. Assessment of the early disabling effects of coronary artery bypass graft surgery using direct measures of physical function. J Cardipulm Re-hab Prev epub: doi: 10.1097/HCR.0000000000000587 [PMC in progress] Rengo JL, Khadanga S, Savage PD, Ades PA. Response to Exercise Training During Cardiac Reha-bilitation Differs by Sex. J Cardiopulm Rehabil Prev. 2020 Sep;40(5):319-324. doi: 10.1097/HCR.0000000000000536. PMID: 32796493. Rengo JL, Savage PD, Hiroshima F, Leavitt BJ, Ades PA, Toth MJ. Improvement in functional re-covery after coronary artery bypass graft surgery using a novel transitional care intervention: a randomized controlled trial. J Cardipulmon Rehab Prev epub: doi: 10.1097/HCR.0000000000000576 [PMC in progress] Silverman DN, Rambod M, Lustgarten DL, Lobel R, LeWinter MM, Meyer M. Heart Rate-Induced Myocardial Ca2+ Retention and Left Ventricular Volume Loss in Patients With Heart Failure With Preserved Ejection Fraction. J Am Heart Assoc. 2020 Sep;9(17):e017215. doi: 10.1161/JAHA.120.017215. Epub 2020 Aug 28. PMID: 32856526; PMCID: PMC7660766. Straight CR, Fedewa MV, Toth MJ, Miller MS. Improvements in skeletal muscle fiber size with resistance training are age dependent in older adults: a systematic review and meta-analysis. J Appl Physiol 129: 392-403, 2020. [PMC 7473942]

Toth MJ, Tourville TW, Voigt TB, Choquette RH, Anair BM, Falcone MJ, Failla MJ, Stevens-Laps-ley JE, Endres NK, Slauterbeck JR, Beynnon BD. Utility of neuromuscular electrical stimulation to preserve quadriceps size and function at the cellular level following anterior cruciate ligament injury and reconstruction: a randomized, sham-controlled, blinded trial. Am J Sports Med 48: 2429-2437, 2020. [PMC 7775613] Toth MJ, Voigt TB, Tourville TW, Prior SM, Schlosberg AV, Forest TJ, Kaufman PA, Wood ME, tul Rehman H, Dittus K. Effects of neuromuscular electrical stimulation on skeletal muscle cell size and function in breast cancer patients receiving chemotherapy J Appl Physiol 128: 1654-1665, 2020. [PMC 7311687] Tourville TW, Choquette RH, Voigt TB, Slauterbeck JR, Beynnon BD, Toth MJ. Skeletal muscle cellular contractile dysfunction after anterior cruciate ligament reconstruction contributes to quadriceps weakness at 6-months follow-up. J Ortho Res (in press)

Unger LA, Azzolin L, Nothstein M, Sánchez J, Luik A, Seemann G, Yeshwant S, Oesterlein T, Dös-sel O, Schmitt C, Spector P, Loewe A. Cycle length statistics during human atrial fibrillation re-veal refractory properties of the underlying substrate: a combined in silico and clinical test of concept study. Europace. 2021 Mar 4;23(23 Suppl 1):i133-i142. doi: 10.1093/euro-pace/euaa404. PMID: 33751084. Wall HK, Stolp H, Wright JS, Ritchey MD, Thomas RJ, Ades PA, Sperling LS. "The Million Hearts Initiative: Catalyzing Utilization of Cardiac Rehabilitation and Accelerating Implementation of New Care Models". J Cardiopulm Rehabil Prev 2020. Sep;40(5):290-293. doi: 10.1097/HCR.0000000000000547. PMID: 32868655 Weissman G, Arrighi JA, Botkin NF, Damp JB, Keating FK, Menon V, Rose-Jones LJ, Singh HS, Sou-koulis V, Kates AM. The Impact of COVID-19 on Cardiovascular Training Programs: Challenges, Responsibilities, and Opportunities. J Am Coll Cardiol. 2020 Aug 18;76(7):867-870. doi: 10.1016/j.jacc.2020.06.026. Epub 2020 Jun 16. PMID: 32561406. Yakubov, S. J., Van Mieghem, N., M.Reardon, M. J., Serruys, P. W., Gada, H., Mumtaz, M.,Deeb, G. M., Kodali, S.,George, I.,Windecker, S.,Kleiman, N.,Chetcuti, S. J.,Sanchez, C.,Dauerman, H. L., Li, S.,Popma, J. J. Propensity-Matched Comparison of Evolut-R Transcatheter Aortic Valve Im-plantation With Surgery in Intermediate-Risk Patients (from the SURTAVI Trial). Am J Cardiol 2020; 131: 82-90.

Division of Dermatology Glenn Goldman, MD, Director http://www.med.uvm.edu/medicine/Dermatology Dermatology at the University of Vermont Medical Center is a division of the Department of Medicine. Our division employs seven general

dermatologists, three surgical dermatologists, a pediatric dermatologist and five experienced physician assistants. We provide general dermatology care to the community as well as specialized consultation with particular strengths in the treatment of psoriasis, cutaneous lupus, dermatomyositis, cutaneous lymphoma, and all forms of skin cancer including melanoma. Despite the COVID pandemic we saw 27,000 patients in 2020, and in 2021 we are at full capacity. While telemedicine has been useful for some of our services, most of our services must be in person either for examination or a procedure. Our staff has done an exceptional job guiding our patients through this challenging year. This year we have begun a collaboration with Four Seasons Dermatology to provide Mohs surgery for modest lesions in an office setting. This collaboration maintains our strong relationship with the community dermatologist while providing patient-friendly outpatient procedures for our mutual patients. This year we said goodbye to David Chen, who joined a private practice in Connecticut. We have hired a new physician, Dr. Katelyn Shea who sees general, surgical, and cosmetic dermatology at UVMMC and preforms outreach in Ticonderoga. Dr. Glenn Goldman finished his year as President of the American College of Mohs Surgery. He published a new textbook Techniques in Dermatologic Surgery. He continues with many committee memberships and chairs with the American College of Mohs Surgery, The American Society for Dermatologic Surgery, and the American Academy of Dermatology. Joseph Pierson, MD is the Dermatology Residency Director. He provides a very high level of academic service and serves as Vice Chair for Faculty Development for the Department of Medicine. Dr. Pierson publishes broadly and has been appointed to the Editorial Board of the American Academy of Dermatology. He is very active in the Association of Professors in Dermatology. Melanie Bui, MD, PhD, is our most active research dermatologist and is exceptionally-dedicated to student and resident research. In the last three years she has mentored 17 medical students. She is our quality leader and this year during the pandemic she initiated and completed a far-reaching overhaul of our melanoma staging, tracking and follow-up system. She is engaged in multiple committees at the medical center, regionally and nationally. Dr. Bui has taken on our public face with multiple appearances in the local media for public education about sun and the

skin as well as women’s dermatological issues. In the past year she and our students and residents had 12 posters, presentations and virtual presentations. Christine Weinberger, MD and Todd Holmes, MD have developed a stellar national reputation in the area of skin cancer surgery and reconstruction. As a team we have as strong of a Mohs surgery unit as exists anywhere in the country. In conjunction with surgical oncology, otolaryngology, radiation oncology and oncology we hold regular tumor board conferences, coordinating care and assuring the highest level of service for our patients. Both Dr. Holmes and Dr. Weinberger have lectured extensively at our national meetings and have outstanding reputations as developing leaders in the field.

Keith Morley, MD continues to offer broad ranging pediatric dermatology services. He provides pulsed dye laser treatment of vascular birthmarks, simple excisions, and diagnostic skin biopsies with sedation in the Comfort Zone if needed. He lectures broadly in the community. Dr. Morley continues as a Pediatric Contributing Editor for Visual Dx, a patient and physician-centered telehealth and public health web-based application. He serves on the Society of Pediatric Dermatology’s Education Committee and the Maintenance of Certification Committee. This year he was appointed to the Advisory Board Representative of the Vermont Dermatology Society to the American Academy of Dermatology (AAD). As always he will be volunteering with Camp Discover, a camp for children with chronic skin conditions.

Dr. Ankit Gor sees patients both at UVMMC and in Plattsburgh at CVPH. He has facilitated NY state telehealth services and is working with the E-consult team to improve the process for outside consultations. Dr. Aliza Fisher and Dr. Julia Barker perform an extremely well-received outreach at CVMC. Our patients in the center of the State now have access to the excellence of these two outstanding UVMMC dermatologists. Evan Piette, MD is an invaluable addition to our faculty. He has established a clinic caring for many of our more complex medical dermatology patients and is working with the Rutland Community Health Center to provide teledermatology services. Each month we host medical students for clinical or research rotations in dermatology. On average, one or two University of Vermont medical students per year choose to enter the field of dermatology. Due to the tremendously-competitive nature of dermatology as a specialty, each student requires careful guidance and assistance in procuring a residency. As usual, last year our two UVM students interested in dermatology matched at excellent training programs. We continue to volunteer regularly at the Community Health Center Free Clinic. Each month, an attending physician supervises the residents and Physician Assistants in the provision of free care to patients at the Community Health Center in Burlington. This provides a service to the community and is also a superior experience for our residents and fellow, who are able to participate in the care of an underserved population.

Faculty Glenn Goldman, MD Rogers and Nancy Follansbee Professor of Medicine Director, Dermatology Division Director, Mohs Surgery and Dermatologic Oncology Fellowship President, American College of Mohs Surgery Board of Directors, American Society for Dermatologic Surgery • Mohs Surgery and Reconstructive Surgery • Management of high-risk skin cancers • Cosmetic Dermatology • Procedural Dermatology Education • National Health Care Policy • Continuing Medical Education • International Dermatologic Surgery Julia Barker, MD Assistant Professor of Medicine • General and Surgical Dermatology • CVMC Berlin Outreach Melanie Bui, MD, PhD Assistant Professor of Medicine • General Medical Dermatology • Immunology • Dermatology Research David Chen, MD Assistant Professor of Medicine • Mohs Surgery and Reconstruction • Cosmetic Dermatology • Medical Student Education Keith Morley, MD Assistant Professor of Medicine • Pediatric Dermatology • Pediatric Laser Surgery Aliza Fischer, MD Assistant Professor of Medicine • General and Surgical Dermatology • CVMC Berlin Outreach Ankit Gor, MD

Assistant Professor of Medicine • General and Surgical Dermatology • CVPH Plattsburgh Outreach

Todd Holmes, MD Professor of Medicine • Surgical Dermatology and Cutaneous Oncology • Mohs and Reconstructive Surgery • Resident and Fellow Education • International Education in dermatologic surgery Joseph Pierson, MD, Col US Army Associate Professor of Medicine • General Medical Dermatology • Residency Education in Dermatology • Faculty Development Evan Piette, MD Assistant Professor of Medicine • General and Surgical Dermatology • Teledermatology • Middlebury Outreach Katelyn Shea, MD Assistant Professor of Medicine • General Medical Dermatology Christine Weinberger, MD Associate Professor of Medicine • Mohs Surgery and Reconstruction • Mohs Surgery for Melanoma • Skin Cancer in Solid Organ Transplant Recipient Fellow MSDO 2020-2021 Julien Beattie-Lanoue, MD, PGY-5 Residents Lucy Ledyard, MD, PGY-4 Alexandra Charos, MD, PGY-4 Daniel Bax, MD, PGY-3 Dustin Taylor, MD, PGY-3 Carli Whittington, MD, PGY-3 Santana VanDyke, MD, PGY-2

Nate Bombardier, MD, PGY-2 Physician Assistants: Anne Klein, PA Anne is a surgical PA, and works with the dermatologic surgeons daily. She trained for years with a plastic surgeon and has exceptional procedural skills. A testament to her skill is that physicians refer patients to her regularly for surgical excisions. She is also active in teaching students and in mentoring those with potential interest in becoming physician assistants. Rich Callahan, PA Rich is experienced in dermatology and provides both medical and minor surgical dermatology care. He brings with him many patients from his former practice. Rich has a particular interest in dermoscopy and has championed the use of this technique for the evaluation of pigmented lesions. Emilie Rainville, PA Emilie was our medical assistant prior to going to PA school. She has trained with us and hits the ground running with a strong background in dermatology. Morgen Rogers, PA Morgen is our newest PA. She started out in dermatology as a medical assistant and we are very pleased to have her back on our team as a physician assistant. Deb Roseman, PA: Deb has been with us for over 16 years. She has decades of experience as a dermatology physician assistant and has a following of thousands of patients for whom she provides care. She is active in teaching students and in mentoring those with potential interest in becoming physician assistants. Editorships and Editorial Boards Dr. Morley Editor for Pediatric Section of VisualDx

Dr. Pierson Editorial Board, Journal of the American Academy of Dermatology Institution Service Dr. Goldman Chair, Medicine Credentials Committee Leadership in Professional Societies: Vermont Dermatologic Society Dr. Goldman President

Dr. Bui Treasurer American Academy of Dermatology Dr. Goldman Chair of the Coding and Reimbursement Committee Dr. Morley AAD Advisory Board Representative for the Vermont Dermatological Society American Society for Dermatologic Surgery Dr. Goldman Board of Directors Dr. Goldman Chair of the ASDS International Traveling Mentorship Committee Dr. Holmes Chair of the ASDS ITMP Fellowship Subcommittee

Dermatology Foundation Dr. Goldman Leader’s Society State / Regional Chair Dr. Pierson Leader’s Society State / Regional Vice Chair American College of Mohs Surgery Dr. Goldman President Faculty, Resident and Fellow Peer-Reviewed Publications Taylor DL, Wildin RS, Morley KW. Novel neonatal presentation of megalencephaly-polymicrogyria-pigmentary mosaicism syndrome (Mppm) related to MTOR mutation: Report of a case. Pediatr Dermatol. Published online December 16, 2020. Whittington CP, Stowman AM, Morley KW. Chondrodermatitis nodularis helicis in a teenager caused by frequent headphone use. Dermatol Online J. 2021;27(1). Ross ADJ, Bombardier N, Schuessler DC, Morley K. Float like a butterfly, sting like one too. Pediatr Dermatol. Published online May 31, 2021.

Division of Endocrinology and Diabetes

Joel J. Schnure, MD, Director

http://www.med.uvm.edu/medicine/endocrinology

The 2020-2021 academic year has been very stressful both emotionally physically and occupationally. Despite this we have continued the trend of increased research and patient care opportunities for the Division of Endocrinology and Diabetes. The Division serves the residents of Vermont and upstate New York with a goal of delivering seamless, system-wide care within the University of Vermont Health Network for endocrine-related disorders.

We now have 5 physicians, 2 nurse practitioners, and 3 certified diabetes educators provide consultative and ongoing care through our outpatient clinic at Tilley Drive, which has approximately 14,000 visits per year (4th in the Department of Medicine); the Division also operates a consult service at the UVM Medical Center and continues to develop outreach endocrine services at our Network partner hospitals, CVPH in Plattsburgh, NY and Central Vermont Medical Center, Berlin, VT. during the Covid pandemic and the cyberattack we have continued to have very robust patient care opportunity. Doing patient care virtually will allow us to expand our telemedicine program The Division continues to make progress in expanding services to patients in the areas of osteoporosis/metabolic bone disease under the aegis of Jennifer Kelly, DO, Director of the Osteoporosis/Metabolic Bone Disease Clinic. She has recently been named the Associate Chief of the Division of Endocrinology and Diabetes, Dr. Kelly, a renowned clinician and researcher in the area of metabolic bone disease, joined our faculty in 2017. Working with Dr. Elizabeth Ames from Orthopedics, they are establishing a fracture liaison service for patients to receive proper evaluation and treatment after sustaining an osteopathic fracture. The DXA Bone Density Machine moved into the Endocrinology clinic on Tilley Drive in early 2020. This has increased our ability to focus on screening and prevention for at-risk patients, even with the restrictions imposed by the pandemic and the cyberattack.. Dr. Kelly is also involved in a research project with Dr. David Lunardini from Orthopedics that examines the use of abaloparatide in healing C2 fractures. Kaitlyn Barrett, DO joined our faculty in mid-August 2019 following completion of her Fellowship in Endocrinology and Diabetes with the Division. As the Division’s newest Assistant Professor, Dr. Barrett continues the excellent patient care and education of trainees that she demonstrated during her fellowship; she also is active in our metabolic bone disease enterprise. A very exciting endeavor is the new “Cardio- metabolic" clinic which is a joint undertaking with Endocrinology and Cardiology. With our existing expertise in telemedicine we have been able to successfully establish a robust and enhanced telemedicine practice with social distancing due to the restrictions placed upon our system because of the Covid-19 pandemic.

Our research initiatives continue at both the clinical and basic levels. Dr. Matthew Gilbert leads the way in clinical trials. He and his collaborators are working on cardiovascular outcome trials with oral GLP-1RAs, analysis of cardiovascular outcome trials with GLP-1 RA and SGLT2 in the elderly, and the use of GLP-1 RA in patients with renal insufficiency. Data from a Division-initiated analysis of the cost-effectiveness of inpatient diabetes consultation (Drs. Schnure and Kelsey Sheahan (our 2nd year Fellow)was published and was presented at the American Diabetes Association meeting in June 2020 The study has shown a substantial decrease in length of stay in patients who receive an early Endocrine consultation. Other ongoing clinical research projects, including a study investigating the various treatment modalities for enteral and parenteral feeding for inpatients (Drs. Gilbert )are proceeding. The Division’s basic research efforts with Drs. Tom Jetton and Jay Gupta continue to focus on pancreatic islet biology, diabetes, and metabolic disease and, in collaboration with Jana Kraft, PhD, on the effects of bioactive lipids on gut microbiota eubiosis, energy metabolism, and aging. Dr. Kraft is a lipid biochemist with expertise in human nutrition; in addition to her basic research with Drs. Jetton and Gupta, she is collaborating with Matthew Gilbert, DO, MPH on a clinical study of dietary dairy lipids and diabetes risk. Our faculty participate in educational activities at multiple levels. Clinical faculty work closely with medical students and residents rotating through the Endocrine Service and they train two Fellows in Endocrinology each year. Dr. Matthew Gilbert has been on the forefront of the simulation lab and continues a vigorous presence in preclinical medical student education Dr. Kelly supervises the Metabolic Bone Conference series and ensures the quality and diverse topic range of this monthly lecture program. She also works with Drs. Nathan and Gilbert to be sure that the Endocrine lectures provided weekly to Endocrine fellows, faculty, and staff are focused on a wide range of Endocrine pathologies and provide the most up-to-date standards of care. The Division’s educational mission is also evidenced by faculty participation in LCOM initiatives, including Dr. Schnure, Dr Gilbert and Dr. Kelly’s service with The Teaching Academy, which promotes education and scholarship of faculty members. The faculty’s medical education focus also extends beyond UVM/UVMMC through CME-accredited, day-long conferences available to healthcare providers in our region. Dr. Kelly was the course director for and a presenter at “Osteoporosis Update for Primary Care,” held in September 2019; Dr. Barrett also presented a program at this conference. Dr. Schnure was the course director for the “2nd Annual Diabetes for Primary Care Conference,” held in November 2019. This conference included local and nationally recognized experts in treating diabetes, heart disease, and peripheral neuropathy. Dr. Schnure was named by Dr Isabelle Desjardins, the Chief Medical Officer at UVMMC, to serve as chairman of the newly formed Diabetes Oversight Task Force. The Task Force has been charged with enhancing the care of our patients with diabetes throughout our network. The Task Force expedites the work of Dr. Gilbert, who continues to serve as Chair of the Inpatient Glycemic Control Committee, whose mission includes education of hospital physicians and staff on glucose management strategies. Dr. Jetton continues to serve as Director of the graduate course, Science Communication, which has become part of the required curriculum for the Cellular, Molecular and Biomedical Sciences Program. Dr. Jetton also continues to teach classes in human structure and function to medical students and was instrumental in updating of curriculum. He also

works one-on-one in his lab to train undergraduate, graduate, and medical students in research techniques. Clearly, the 2020-2021 year was a busy, productive, and very challenging one for the Division of Endocrinology and Diabetes and the programmatic and research strides made this year ensure the continued effectiveness of our service and education missions.

Faculty Joel J. Schnure, MD

Professor of Medicine Director, Division of Endocrinology and Diabetes Chair, Diabetes Oversight Task Force, UVMMC Member, The Teaching Academy Member, DOM Operations and Efficiency Committee Lead, Diabetes Chronic Care Initiative Lead, Task Force on In-patient Diabetes Education Member, In-patient Diabetes Initiative Research and clinical interests: Diabetes care for Type 1, Type 2, and diabetes in pregnancy Thyroid disease Pituitary disease Integration of home glucose monitoring into electronic medical records Fructosamine as an alternative to HbA1C in pregnancy Web-based algorithms in titration of basal insulin in adults with Type 2 diabetes HbA1c and fructosamine in early pregnancy: correlation to 24-28 week OGTT Cost-effectiveness of endocrine consultation in inpatients with diabetes

Kaitlyn Barrett, DO

Assistant Professor of Medicine Research and clinical interests: Metabolic bone disease and osteoporosis Thyroid disorders Diabetes mellitus Male hypogonadism

Matthew P. Gilbert, DO, MPH

Associate Professor of Medicine Director, Endocrinology Fellowship Program Chairman, Inpatient Diabetes Management subcommittee of P and T Research and clinical interests: Diabetes mellitus Thyroid disorders Thyroid cancer Male hypogonadism

Dhananjay (Jay) Gupta, PhD

Research Assistant Professor Research interests: Pathogenesis of type 2 diabetes and islet biology

Epigenetic regulation of adaptive islet beta cell response with changing metabolic milieu Thomas L. Jetton, PhD

Professor of Medicine Research interests: Nutrient and neural regulation of β-cell mass homeostasis Diet influence on intestinal microbiota and autoimmune disease susceptibility

Teaching interests: Human Structure and Function Gastrointestinal Physiology Regulation of Energy Homeostasis Science Communication

Jennifer Kelly, DO, FACE

Associate Professor of Medicine Associate Chief of the division of Endocrinology and diabetes Chairman of the Faculty Engagement Committee of the Department of Medicine Director of the Metabolic Bone Program Member, The Teaching Academy Research and clinical interests: Osteoporosis Metabolic bone disorders, including Paget’s Disease of Bone Diabetes mellitus

Muriel H. Nathan, MD, PhD Professor of Medicine Research and clinical interests: Diabetes (including use of insulin pumps) and PCOS Thyroid cancer, thyroid nodules, and hyper- and hypothyroidism Pituitary tumors and dysfunction Adrenal disorders, hirsutism Inpatient improvement projects funded by the James M. Jeffords Institute for Quality ~

SQ and IV insulin forms, insulin pump, DKA

Fellows Shreya Amin, MD (F4, will begin training 7/1/2020; expected completion 6/30/2022) Samantha Steinmetz-Woods Nurse Practitioners and Certified Diabetes Educators Ann Gotham, ANP, MSN, ScM Chassidy Deslauriers, MBA, RD, CDE Mary Spence, RN, CDE Linda Tilton, MS, RD, CDE Laurie Davignon, RN, APRN Graduate Students, Post-doctoral Fellows, MD PhD Students None Endowed Professorships Leadership in Professional Societies Matthew P. Gilbert, DO, MPH

Vermont Board of Osteopathic Physicians and Surgeons, Secretary as of November 2019 Dhananjay (Jay) Gupta, PhD

American Diabetes Association American Society for Biochemistry and Molecular Biology Boston-Ithaca Islet Club

Thomas L. Jetton, PhD

Boston-Ithaca Islet Club, senior member

Jennifer J. Kelly, DO, FACE National Osteoporosis Foundation, member of the Ambassadors Leadership Council American Association of Clinical Endocrinologists national organization:

Task Force to Update the AACE/ACE Postmenopausal Osteoporosis Clinical Practice Guidelines Membership Committee, member Bone and Parathyroid Disease State Network Committee, member Thyroid Disease State Network Committee, member

American Association of Clinical Endocrinologists, New England Chapter, Board of Directors International Society of Clinical Densitometry, Web Advisory Committee member New England Bone Club, 2018 and 2019 Annual Meeting Planning Committee member American Association of Clinical Endocrinologists (AACE) national organization, Bone and

Parathyroid Disease State Network Committee member and Thyroid Disease State Network Committee memberships

Chair of the 2023 International Society of Clinical Densitometry annual meeting planning committee

American Association of Clinical Endocrinologists (AACE) New England Chapter, Board of Directors

National Osteoporosis Foundation Ambassadors, Leadership Council member New England Bone Club, 2018 Annual Meeting planning committee member American Association of Clinical Endocrinologists (AACE) national organization,

Thyroid and Parathyroid Disease State Network Committee member American Association of Clinical Endocrinologists (AACE) New England Chapter,

Course director for Regional Meeting, Lebanon, NH. American Association of Clinical Endocrinologist (AACE) New England Chapter,

Board of Directors and Co-chair of the 2021 Annual Meeting Planning committee. member for Diabetes Day for Primary Care Providers

New England Endocrine Alliance Bylaws Revision Task Force, member American Association of Clinical Endocrinologists Diversity, Equity and Inclusion

Task Force, member International Society of Clinical Densitometry, Annual Meeting Planning

Committee member, Ask the Experts member. Diversity, Equity and Inclusion Committee, member .

Muriel H. Nathan, MD, PhD

New England Thyroid Club, senior member

Editorships and Editorial Boards Dhananjay (Jay) Gupta, PhD

Editorial Board: Journal of Endocrinology, Diabetes and Obesity Reviewer: Diabetes, Diabetes Care, Science Reports, Journal of the Endocrine Society, Journal

of Nutritional Biochemistry, Life Sciences, International Journal of Chronic Diseases Thomas L. Jetton, PhD

Reviewer: Diabetes, Endocrinology, PNAS, Metabolism, Diabetologia, American Journal of Physiology, PLosOne

Joel J. Schnure, MD

Editorial Board: Coronary Artery Disease Study Sections and Federal Advisory Boards Dhananjay (Jay) Gupta, PhD

Grant Review Panel, Diabetes UK Thomas L. Jetton, PhD

Federal review boards: EMNR-Study Section (SBIR and STTR), ad hoc reviewer NIDDK/NIH, ad hoc reviewer NIH (S10 SIG/SIFAR), ad hoc reviewer

Major Faculty Awards None Grants and Research Dhananjay (Jay) Gupta, PhD

Department of Medicine (UVM) IGP Research Award Vitamin D Signaling and Bioavailability in Pre-Clinical Models of Type 2 Diabetes (1/15/2020-1/15/2021) Role: Principal Investigator

Jennifer J. Kelly, DO, FACE

Shire/Takeda PARADIGHM (Physicians Advancing Disease Knowledge in Hypoparathyroidism): A Registry for Patients With Chronic Hypoparathyroidism (2018-present) Role: Site Principal Investigator

Repository of Dual-Energy X-Ray Absorptiometry (DXA) Scans for Image Manipulation and Enhancement (2019-present)

Role: Site Principal Investigator

Osteoporosis Center DXA Data Repository (2019-present) Role: Site Principal Investigator

Publications Camacho PM, Petak SM, Binkley N, Diab DL, Eldeiry LS, Farooki A, Harris ST, Hurley DL, Kelly J, Lewiecki EM, Pessah-Pollack R, McClung M, Wimalawansa SJ, Watts NB. American Association of Clinical Endocrinologists/American College of Endocrinology Clinical Practice Guidelines for the Diagnosis and Treatment of Postmenopausal Osteoporosis – 2020 Update Executive Summary. Endocr Pract. 26(5):564-570, 2020. Camacho PM, Petak SM, Binkley N, Diab DL, Eldeiry LS, Farooki A, Harris ST, Hurley DL, Kelly J, Lewiecki EM, Pessah-Pollack R, McClung M, Wimalawansa SJ, Watts NB. American Association of Clinical Endocrinologists/American College of Endocrinology Clinical Practice Guidelines for the Diagnosis and Treatment of Postmenopausal Osteoporosis – 2020 Update. Endocr Pract. 26(Suppl 1):1-46, 2020. Gilbert MP. Screening for Diabetic Retinopathy. Healio Educational Lab Case Series. https://cme.healio.com/endocrinology/education-lab/ace-the-case/2019/03_march/ace-the-

case-patient-with-15-year-history-of-type-2-diabetes-mellitus/cme-information. Available August 15, 2019 through August 14, 2020. Gilbert MP. Ace the Case: A 55-Year-Old, Postmenopausal Woman with an Elevated Calcium Level. https://cme.healio.com/endocrinology/education-lab/ace-the-case/2019/01_january/a-55-year-old-postmenopausal-woman-with-an-elevated-calcium-level/cme-information. Available September 16, 2019 through September 15, 2020. Gilbert MP. Ace the Case: Patient with a 20-Year History of Type 2 Diabetes Mellitus and Concern Regarding the Risk of Coronary Heart Disease. https://cme.healio.com/endocrinology/education-lab/ace-the-case/2019/03_march/patient-with-a-20-year-history-of-type-2-diabetes-mellitus/cme-information. Available October 15, 2019 through October 14, 2020. Gilbert MP. Ace the Case: A Patient with New-Onset Primary Hypothyroidism. Healio Educational Lab Case Series. https://cme.healio.com/endocrinology/ace-the-case/20190601/ace-the-case-a-patient-with-new-onset-primary-hypothyroidism/overview. Available November 15, 2019 through November 14, 2020. Gilbert MP, Pratley RE. GLP-1 analogs and DPP-4 inhibitors in Type 2 diabetes therapy: Review of head-to-head clinical trials. Front Endocrinol (Lausanne). 2020 Apr 3;11:178. Kelly JJ. Bone turnover markers in osteoporosis—letter to the JAMA editor in response to “Bauer DC. Clinical use of bone turnover markers. JAMA. 2019;322(6):569-570.” JAMA. 2019;322(23):2344. Kelly JJ and Garapati SS. Combination therapies in the treatment of osteoporosis. Curr Opin Endocrinol Diabetes Obes. 26(6):292-295, 2019. Leahy JL, Aleppo G, Fonseca VA, Garg SK, Hirsch IB, McCall AL, McGill JB, Polonsky WH. Optimizing Postprandial Glucose Management in Adults with Insulin-Requiring Diabetes: Report and Recommendations. J Endocr Soc. 2019 Oct 7;3(10):1942-1957. Pratley RE, Emerson SS, Franek E, Gilbert MP, Marso SP, McGuire DK, Pieber TR, Zinman B, Hansen CT, Hansen MV, Mark T, Moses AC, Buse JB, on behalf of the DEVOTE Study Group. Cardiovascular safety and severe hypoglycaemia benefit of insulin degludec versus insulin glargine U100 in patients with type 2 diabetes aged 65 years or older: results from DEVOTE (DEVOTE 7). Diabetes Obes Metab. 2019;21:1625-1633. Shahady E, Leahy JL. Sodium-Glucose Cotransporter 2 Inhibitor Protection Against Adverse Cardiovascular and Renal Outcomes in Patients with Type 2 Diabetes. Clin Diabetes. 2019 Jul;37(3):211-220.

Sheahan KH, Wahlberg EA, Gilbert MP. An overview of GLP-1 agonists and recent cardiovascular outcomes trials. Postgrad Med J. 2020 Mar; 96(1133):156-161. Sheahan KH, Huffman GC, DeWitt JC, Gilbert MP. Metastatic lung cancer presenting as monocular blindness and panhypopituitarism secondary to a pituitary metastasis. Am J Case Rep 2020 Apr; 21:e920948 Doi: 10.12659/AJCR.920948. Tharp WG, Gupta D, Sideleva O, Deacon CF, Holst JJ, Elahi D, Pratley RE. Effects of Pioglitazone on Glucose Dependent Insulinotropic Polypeptide Mediated Insulin Secretion and Adipocyte Receptor Expression in Patients with Type 2 Diabetes. Diabetes. 2020 Feb;69(2):146-157. Unger AL, Eckstrom K, Jetton TL, Kraft J. Colonic bacterial composition is sex-specific in aged CD-1 mice fed diets varying in fat quality. PLoS One. 2019(Dec 18);14(12): e0226635. doi: 10.1371/journal.pone. Abstracts Gilbert MP, DeVoe SG, Nevares A, Teneback CC. Improving Health Care Transitions for Young Adults at the University of Vermont Medical Center. Poster presented at University of Vermont Medical Center Department of Medicine Scholarly Quality Improvement Poster Session; May 8, 2020; Virtual Presentation. Sheahan K, Atherly A, Dayman CE, Schnure JJ. The Impact of Rapid Inpatient Endocrinology Consultations on Hospital Outcomes. American Diabetes Association 80th Scientific Session, Virtual Poster Session, Chicago, IL, June 12-16. Diabetes 2020;69 Supplement (1):143-LB. Sheahan K, Rankins C, Nathan MH, Kelly J. A Case of Isolated Elevated Free Triiodothyronine; poster presented at the American Association of Clinical Endocrinologists (AACE) 2020 Annual Scientific and Clinical Congress. Endocr Pract. 2020 May; 26(Suppl 4):281. Sheahan K, Tompkins B, Kennedy AG, Repp AB, Gilbert MP. Impact of a Nursing Strike on Glycemic Control of Hospitalized Patients with Diabetes. American Diabetes Association 80th Scientific Session, Virtual Poster Session, Chicago, IL, June 12-16. Diabetes 2020;69 Supplement (1):1201-P. Vennard-Barrett K, Kennedy AG, Repp AB, Tompkins B, Gilbert MP. Predictors and Consequences of Inappropriate Thyroid Ultrasound. Poster #456. 89th Annual Meeting of the American Thyroid Association, Chicago IL, October 30-November 3, 2019. Presentations Joel J Schnure, MD

Sheahan K, Atherly A, Dayman CE, Schnure JJ. The Impact of Rapid Inpatient Endocrinology Consultations on Hospital Outcomes. American Diabetes Association 80th Scientific Session, Kaitlyn Barrett, DO

“Post-Transplant Diabetes Mellitus” presented at Transplant Surgery monthly meeting at UVMMC on January 30, 2020. “Diabetes Updates and Management for the Anesthesiologist” presented at Anesthesia Grand Rounds at UVMMC on May 21, 2020.

Matthew P. Gilbert, DO, MPH “Diabetes Management: Beyond Glycaemic Control” presented at the Global Diabetes Summit held in Frankfurt, Germany, October 4-5, 2019.

Jennifer J. Kelly, DO, FACE

Course Director for “Osteoporosis Update for Primary Care” and speaker for “What’s New in Osteoporosis 2019,” presented September 27, 2019 at the UVM Davis Center. “Boning Up on Bone Health” at the 25th annual Vermont 50+ Expo held February 15, 2020 at the University Mall in South Burlington.

Joel J. Schnure, MD Course Director for "Diabetes 2019: Updates on Management and Treatment," the 2nd annual Diabetes for Primary Care Conference; attendees were primary care providers and clinicians from Vermont, New Hampshire, Maine, and upstate New York. November 8, 2019; Burlington, Vermont.

Annual Report July 1, 2020-June 30, 2021

Division of Gastroenterology and Hepatology Richard Zubarik, MD, Section Chief http://www.med.uvm.edu/medicine/gastro/home The Gastroenterology and Hepatology Division at the University of Vermont College of Medicine/University of Vermont Medical Center has eight Gastroenterologists, one Advanced Practice Provider and four GI Fellows. 2020-21 has been a tough year for the gastroenterology division, the medical center, and the health care system in general. We continued to navigate the COVID pandemic and endured a Cyber-attack. Fortunately, our two senior fellows have decided to continue to practice within our Network. Dr. Jason Heffley has accepted a faculty position at UVMMC and Dr. Brendan Everett will be practicing at Central Vermont Hospital. During the COVID pandemic the cohesion, compassion, comradery, ingenuity and grit of the UVMMC gastroenterology division has never been so evident and needed. These traits were evident in our care of patients, our role as educators, and in the research, we conducted. We have continued to provide exceptional gastrointestinal care to our community through this period. In recognition of this, Dr. Ganguly was awarded the distinguished clinician award this year. There is a balance between protecting patients and staff from infection and continuing to provide both the important urgent and preventive gastrointestinal care for our patients. We have continued to provide both urgent and preventive GI care, but have made the workplace as safe as possible through appropriate protective equipment, smart scheduling and encouragement of vaccination. Telehealth visits have also played an important role in our Division this year and will likely continue for the foreseeable future. During the COVID pandemic, they have allowed for quality patient care while limiting infectious exposure. They also have allowed improved access to care for patients distant from the Medical Center. Education of Fellows and Residents remains strong. Dr. Ferrentino continues to be our Fellowship Director. Education continues to be a priority for all members of our division. An example of this is that Dr. Reddy was awarded the Outstanding Teacher of the Year, Subspecialty Medicine Award. In addition, Dr. Ganguly and Dr. Reddy wrote a teaching curriculum to aide in teaching the Primary Care Residents. The challenges of maintaining social distancing resulted in us conducting conferences this year using teleconferencing. Although teleconferencing has limitations, it did allow us to stay connected and include physicians in our conferences that would otherwise have been difficult to include. Likely, this platform will be used in the future as we develop into a Network Department and try to reach learners at affiliated hospitals. During this period, we were able to continue our regular educational conferences using teleconferencing, as well as adding gastroenterology morning report conferences to enhance the educational experience of our fellows and residents. Research efforts this year were challenging due to the COVID pandemic. Despite this, we continued to publish articles in both peer reviewed journals and in Stat-of-the-Art textbooks on topics such as gastrointestinal stenting, peptic ulcer disease, helicobacter pylori, jaundice, gut neurobiology and inflammatory bowel disease.

In summary, the Gastroenterology and Hepatology Division at the University of Vermont remains strong. The unprecedented challenges of this time have strained our system like no other. Through this time, it is clear that the greatest strength we have is our human capital. Our unit has always been about cohesion, collegiality, providing state-of-the-art compassionate care to patients in need, educating the future wave of health care providers, and having scientific inquisitiveness. These are the characteristics that are supporting us through this difficult time and because of our collective talents, the Gastroenterology Unit remains strong. I am very proud to be part of this Division.

Richard Zubarik, MD Nicholas Ferrentino, MD Associate Professor of Medicine Director, GI Fellowship Program Chronic Viral Hepatitis Management of Cirrhosis General Gastroenterology and General Hepatology Therapeutic Endoscopy

Joseph Frasca, MD Assistant Professor of Medicine Director of Inflammatory Bowel Disease Inflammatory Bowel Disease Crohn’s Disease Ulcerative & Microscopic Colitis Celiac Disease Biliary Tract Disorders

Eric Ganguly, MD Professor of Medicine Director of Endoscopy GI Oncology Endoscopic Ultrasound and GI Malignancies Barrett’s Esophagus and Radiofrequency Ablation for Barrett’s Esophagus Therapeutic Endoscopy GERD Inflammatory Bowel Disease

Steven Lidofsky, MD, Ph.D. Professor of Medicine and Pharmacology Director, Hepatology Co-Director, Gastrointestinal Research Director, MD-Ph.D. Program

Cirrhosis Hepatocellular Carcinoma Hepatitis C Nonalcoholic Fatty Liver Disease

Gary Mawe, Ph.D. Professor of Neurological Sciences; Adjunct Professor of Medicine and of Pharmacology Neural Regulation of the Digestive Tract

(understanding changes in enteric neural circuits that contribute to altered gut function in inflammatory bowel disease and irritable bowel syndrome)

Sheela Reddy, MD Assistant Professor of Medicine Alcohol Related Liver Disease Viral Hepatitis Nonalcoholic Fatty Liver Disease Autoimmune Liver Diseases Role of Liver Transplantation in Patients with End Stage Liver Disease

Jane Roberts, MD, Ph.D. Assistant Professor of Medicine Functional Bowel Disorders Intestinal Motility and Manometry Eosinophilic Esophagitis Irritable Bowel Syndrome (IBS) Dyspepsia Celiac Disease GERD

Doris Strader, MD Professor of Medicine Viral Hepatitis Hepatitis C Nonalcoholic Fatty Liver Disease Eosinophilic Esophagitis Cirrhosis General Hepatology and General Gastroenterology

Richard Zubarik, MD Professor of Medicine Director of Gastroenterology & Hepatology Division GI Oncology Pancreatic Disorders Dysphagia Inflammatory Bowel Disease Therapeutic Endoscopy and EUS Endoscopic Ultrasound

Maia Stamieszkin, NP Nurse Practitioner

• IBS • FODA Map

Stacy Shen, MD GI Fellow Brendan Everett, MD GI Fellow Abubakar Ibrahim, MD GI Fellow Jason Heffley, MD GI Fellow Leadership in Professional Studies: Steven Lidofsky, MD, Ph.D. AASLD Leadership Public and Clinical Policy Committee Abstract review hepatobiliary neoplasia for Liver Meeting and DDW Appointed as Vice Chair, American Association for the Study of Liver Diseases Public Policy

Committee (January 2021-December 2021) Gary Mawe, Ph.D. Director, Anatomical Gift Program, The University of Vermont, College of Medicine, 2015-present. Planning Committee and C-chair, NIH NIDDK Workshop on Brain Gut interactions in

Neurodegenerative Diseases, 2019-2021 Fundamentals of Neurogastroenterology – Co-Chair Basic Science Committee, The Rome

Foundation. The purpose of this committee is to develop a summary of the research and literature to date related to functional gastrointestinal disorders, and then offer guidelines or recommendations to help advance future research. 2021-present

Chair, Journal Management Committee, Neurogastroenterology and Motility, 2019-present

Editorships and Editorial Boards: Steven Lidofsky, MD, Ph.D. Ad hoc reviewer for American Journal of Gastroenterology Ad hoc reviewer for Clinical Therapeutics Ad hoc reviewer for Hepatology

Gary Mawe, Ph.D. Editorial Board: Frontiers in Autonomic Neuroscience, 2010-present Editorial Board: Frontiers in Gastrointestinal Sciences, 2011-present Editorial Board: Journal of Visualized Experiments, (JoVE), 2011-present

Doris Strader, M.D. Reviewer, American Journal of Gastroenterology, Clinical Gastroenterology & Hepatology, 2009-

Present Reviewer, Digestive Diseases and Sciences 2010- present Reviewer, AASLD publication, Hepatology Journal 2010-present

Richard Zubarik, M.D. Editorial Board Member, World Journal of Gastroenterology 2012-present Reviewer, Gastrointestinal Endoscopy 2004-present Reviewer, Evidence-Based Gastroenterology 2001-present Reviewer, Journal of Gastroenterology 2006-present Reviewer, Archives of Internal Medicine 2010-present Reviewer, Digestive Diseases and Sciences 2010- present Reviewer, International Journal of Inflammation 2012-present Reviewer, American Society for Gastrointestinal Endoscopy Publications Committee Reviewer, Journal of Endocrinological Investigation, 2015-Present

Study Sections and Federal Advisory Boards: Steven Lidofsky, MD, Ph.D. Vermont Department of Health Steering Committee for Viral Hepatitis Appointed to Editorial Board, World Journal of Hepatology

Doris Strader, MD Director of Data Safety Monitoring Board for NIH Hepatitis B Research Network, 2011-Present

Grants – list all active by faculty member, PI Steven Lidofsky, MD, Ph.D. Steven Lidofsky (PI of subaward)

NIH U54 GM115516 NNE CTR Network (July 2019- June 2021) Harnessing the electronic health record in primary care for hepatocellular carcinoma surveillance in cirrhosis

UVMHN Medical Group (Steven Lidofsky, Co-PI with Andrew Hale) Empowering hepatitis C management in primary care by electronic linkage to specialty guidance (January 2020 - December 2021)

Pharmaceutical Sponsored Research Steven Lidofsky, MD, Ph.D.

• Intercept: A phase 3 randomized long-term placebo-controlled multicenter study evaluating the safety and efficacy of obeticholic acid in subjects with nonalcoholic steatohepatitis (NASH)

• Target Pharmasolutions: A multi-center study of the management and outcomes of subjects with nonalcoholic fatty liver disease

• Intercept: A phase 2 randomized, long-term placebo-controlled multicenter study evaluating the safety and efficacy of obeticholic acid in subjects with cirrhosis due to NASH

• Celgene: A phase 2 multicenter study of the JNK inhibitor CC-90001 for non-alcoholic steatohepatitis (NASH) with advanced hepatic fibrosis or cirrhosis

• Gilead (Steven Lidofsky, Site PI) A phase 3 randomized controlled trial for the FXR agonist cilofexor for noncirrhotic primary sclerosing cholangitis (2020-2022).

Joseph Frasca, MD Site Principal Investigator. A Phase 3, Multicenter, Randomized, Efficacy Assessor-Blinded study of

Risankizumab Compared to Ustekinumab for the Treatment of Adult Subjects with Moderate to Severe Crohn’s Disease who have failed anti-TNF therapy. AbbVie-Crohn’s

Jane Roberts, MD, PhD Site Principal Investigator. A Phase 3, Multicenter, Multinational, Randomized, Double Blind,

Placebo Controlled Induction and Maintenance Study to Evaluate the Efficacy and Safety of CC-93538 in Adult and Adolescent Subjects with Eosinophilic Esophagitis. Celgene

Other Research Richard Zubarik, MD Pancreatic Cancer Screening Employing CA 19-9 and Targeted Endoscopic Ultrasound (EUS) in a High

Risk Population A Pilot Study to Determine if the Endoscopic Dilation Monitor can Create Real-Time

Pressure/Volume and Pressure/Time Curves during Endoscopic Balloon Dilation of Esophageal Strictures, and if these Curves Vary According to Stricture Etiology.

Choledocholithiasis After Normal Diagnostic Cholaniogram or Endoscopic Clearance of Bile Duct The Incidence and Risk Factors for Development of Ascending Cholangitis Following Common Bile

Duct Stent Placement Publications – peer reviewed, chapters, etc. (not abstracts) Rupal H Patel 1, Brendan T Everett 2, Dmitriy Akselrod 3, Joseph D Frasca 2, Stuart R Gordon 1 Fatal Aortoesophageal Fistula Complicating Placement of a 20-mm Lumen-Apposing Metal Stent for Refractory Esophagojejunal Anastomotic Stricture. ACG Case Rep J. 2021 Mar 19;8(3):e00548. eCollection 2021 Mar.PMID: 33758764 Rodriguez N, Kennedy AG, Tompkins BJ, VanOpdorp J, Heffley J, Ganguly E. Quality Improvement opportunities exist for Helicobacter pylori treatment and confirmatory testing. Clinics and Research in Hepatology and Gastroenterology 2021 Jun 1:45(5):101720. PMID: 34087425 Lidofsky SD. 2020. Jaundice. In Feldman M Friedman LS Brandt LJ. (eds.) Sleisenger and Fordtran’s Gastrointestinal and Liver Disease 11th ed. pp.313-323. Philadelphia, Elsevier. Jessica W. Crothers, 1,5 Nathaniel D. Chu,2,3 Le Thanh Tu Nguyen,2,3 Magen Phillips,4 Cheryl Collins,4 Karen Fortner,4 Roxana Del Rio-Guerra,6 Brigitte Lavoie,7 Peter Callas,8 Mario Velez,4 Aaron Cohn,4 Ryan J. Elliott,9 Wing Fei Wong,9 Elaine Vo,10 Rebecca Wilcox,1,5 Mark Smith,10 Zain Kassam,10 Ralph Budd,4,5 Eric J. Alm,2,3 Gary M. Mawe,7 and Peter L. Moses5,10. Daily, oral FMT for long-term maintenance therapy in ulcerative colitis: results of a single-center, prospective, randomized pilot study. BMC Gastroenterol. 2021; 21: 281. PMID: 34238227 John R Konen 1 2, Melody M Haag 1, Daria Guseva 3, Molly Hurd 1, Alisha A Linton 1, Brigitte Lavoie 1, Colleen B Kerrigan 1 2, Emily Joyce 1, Stephan C Bischoff 3, Steve Swann 4, Luana Griffin 4, Jun Matsukawa 4, Matthew D Falk 4, Tony S Gibson 4, Grant W Hennig 5, Jill Wykosky 4, Gary M Mawe 1 5 Prokinetic actions of luminally acting 5-HT 4 receptor agonists Neurogastroenterol Motil. 2021 Apr;33(4):e14026 Epub 2020 Nov 1.PMID: 33185015

Karolyn G Lahue 1, Montana K Lara 2, Alisha A Linton 2, Brigitte Lavoie 2, Qian Fang 3, Mahalia M McGill 1, Jessica W Crothers 4, Cory Teuscher 3 4, Gary M Mawe 2, Anna L Tyler 5, J Matthew Mahoney 2 6, Dimitry N Krementsov 7 Identification of novel loci controlling inflammatory bowel disease susceptibility utilizing the genetic diversity of wild-derived mice. Genes Immun. 2020 Nov;21(5):311-325. Epub 2020 Aug 26 PMID: 32848229 Sprouse-Blum, AS, B Lavoie, M Haag, SM Mawe, EA Tolner, AMJM van den Maagdenberg, S-P Chen, K Eikermann-Haerter, L Ptacek, GM Mawe, and RE Shapiro (2020) No gastrointestinal dysmotility in transgenic mouse models of migraine. Headache. 60:396-404 PMID: 31876298 Spear, E.T. and G.M. Mawe (2020) Enteric neuroplasticity and dysmotility in inflammatory disease: key players and possible therapeutic targets. American Journal of Physiology 317:G853-G861. PMID: 31604034 Jason D Heffley 1, Richard Zubarik 1. A standardized protocol improves testing rates for Helicobacter Pylori among inpatients with peptic ulcer disease. Helicobacter 2021 Jun;26(3):e12800. . Epub 2021 Mar 15. PMID: 33720493

General Internal Medicine & Geriatrics Jennifer Gilwee, MD, Division Chief http://www.med.uvm.edu/medicine/generalinternalmedicinegeriatrics/home

The Division of General Internal Medicine specializes in diagnosing, treating, and preventing medical problems across generations from adolescents to our oldest adults. Our general internal medicine physicians work with their teams in the outpatient clinics to care for a large proportion of patients in our area. Throughout the COVID-19 pandemic we have worked hard to maintain our high standards of care by utilizing telemedicine and safe in-person protocols. This allowed our patients to still get the care they needed without exposing them to potential risk of

contracting the virus. Our faculty physicians teach the principles of general internal medicine to medical students, resident physicians, professional colleagues, and community members. We hold several leadership roles at the College of Medicine and are proud to serve an integral role in our vibrant academic medical center. Service: Our clinical service includes approximately 42 physicians, nurse practitioners and physician assistants. We have four outpatient sites in Chittenden County. In the office setting, patients are seen for a variety of acute and chronic medical problems, preventive care, health maintenance and preoperative exams. Our group has been a national leader in developing innovative models for care delivery. All four outpatient sites have been consistently recognized as NCQA as level 3 Patient Centered Medical Homes. In the era of new payment structures for health care, we have been transitioning to more value-based care models from the traditional fee-for-service model. This year our general internal medicine faculty and providers will conduct approximately 70,000 patient encounters via in-person and virtual care (telemedicine and e-visits). Our faculty and providers are extensively engaged in service at the state and national levels. A few examples include: Past-President of the New England Society of General Internal Medicine, Membership Chair of the New England Society of General Internal Medicine, member of the State Board Advisory Committee to the USMLE, member of the Vermont Commissioner of Health’s Task Force on Opioid Prescribing, USMLE Composite Committee member,

Vermont Medicaid Drug Utilization Board members, OneCare Vermont Regional Clinician Representative, OneCare Population Health Committee Representative, Vermont Blueprint for Health Executive Committee, Councilor of the Vermont Chapter of the Alpha Omega Alpha Medical Honor Society Education: Division faculty members play a pivotal role in teaching and directing courses for a broad audience of clinical learners in the outpatient and inpatient settings. Our educational programs cover a wide spectrum, from communication skills to clinical skills, and from pre-medical students to post-graduate continuing medical education. This past year our faculty hosted nearly all of the third year outpatient internal medicine clerkship students throughout our four clinic sites when COVID-19 limited travel to other teaching locations. At the UVM College of Medicine, our faculty member’s act as preceptors, instructors, and facilitators for courses at all levels of the Vermont Integrated Curriculum. Additionally, we serve as course directors for Convergence (Dr. Patricia King), Outpatient Medicine Clerkship (Dr. Roberta O’Brien and Dr. Dennis Beatty). Administrative leadership positions at the College of Medicine include the Associate Dean for Primary Care (Dr. Charles Maclean). We also play key roles in the clinical education of the Internal Medicine residents. Dr. Halle Sobel is an Associate Program Director. Our Adult Primary Care Burlington site houses the Internal Medicine Resident Clinic – where the Internal Medicine residents practice under the supervision of our preceptors and firm leaders in a busy clinic environment. Dr. Richard Pinckney and Dr. Halle Sobel lead the curricular coordination for the Resident Clinic. Research Many of our clinical faculty conduct research via the General Internal Medicine Research unit and provide mentorship, resources, and a scholarly community that supports faculty from many departments in their investigations. We have a diversity of scholarly interests among our faculty including the impact of primary care redesign and mental health integration, narcotic prescribing practices in the outpatient setting, innovative models in medical education and curriculum development, the use of portable technology in hypertension control, the role of inflammation in chronic disease management and disparities of health in rural populations. Faculty Adult Primary Care - Burlington Claudia Berger, MD (Site Clinical Leader)

Assistant Professor of Medicine Amy Dinitz, MD Assistant Professor of Medicine Michael Latreille, MD Assistant Professor of Medicine Benjamin Littenberg, MD (see Division of GIM-Research) Professor of Medicine Director, Division of General Internal Medicine - Research Scott Luria, MD Associate Professor of Medicine (Emeritus) John Miller, MD Assistant Professor of Medicine Richard Pinckney, MD, MPH Associate Professor of Medicine Co-Director, Internal Medicine Resident Clinic Halle Sobel, MD Associate Professor of Medicine Associate Program Director, Internal Medicine Resident Program Emily Hadley Strout, MD Assistant Professor Medicine

Adult Primary Care - Essex Tania Bertsch, MD Associate Professor of Medicine (Emeritus) Gary Gilmond, MD Assistant Professor of Medicine Diane Haddock, MD (Site Clinical Leader) Assistant Professor of Medicine Patricia King, MD, PhD Professor of Medicine Convergence Course Director, Vermont Integrated Curriculum, UVM College of Medicine

Charles MacLean, MD (see Division of GIM-Research) Professor of Medicine Associate Dean for Primary Care

• Health services research and epidemiology Roberta O’Brien, MD Associate Professor of Medicine Director, Outpatient Internal Medicine Clerkship Christopher Wargo, MD Assistant Professor of Medicine Adult Primary Care – South Burlington Dennis Beatty, MD Associate Professor of Medicine Associate director, Outpatient Internal Medicine Clerkship Jennifer Gilwee, MD Associate Professor of Medicine Division Chief, General Internal Medicine Jason Gramling, MD Assistant Professor of Medicine Emily Greenberger, MD Assistant Professor of Medicine Diane Hakey, MD Assistant Professor of Medicine Sara Roberts, MD Assistant Professor of Medicine Marie Sandoval, MD (Site Clinical Leader) Associate Professor of Medicine Elizabeth Wahlberg, MD Assistant Professor of Medicine Susan Weinstein, DO Assistant Professor of Medicine

Adult Primary Care - Williston Anne Breña, MD Assistant Professor of Medicine

Lucy Miller, MD (Site Clinical Leader) Assistant Professor of Medicine Jonathan Benjamin Wilfong, MD Assistant Professor of Medicine Other Division Members: Timothy Plante, MD, MHS Assistant Professor of Medicine Adam Atherly, Ph.D. Director of the Health Services Research Center Professor of Medicine Nurse Practitioners, Physician Assistants, and Mental Health Specialists: Adult Primary Care - Burlington Tracey Niquette, NP Adult Primary Care - Essex Sarah Bushweller, PA Alison Hall, PA David Spence, PA Adult Primary Care - South Burlington Diane Bell, NP Rachel Brodie, PA Sarah McLaughlin, NP Desiree Price, NP Adult Primary Care - Williston Genevieve Flanders, PA Meagan Goodwin, NP Leadership in Professional Societies:

• Patricia King, MD, PhD Chair, Composite Committee of United States Medical Licensing Exam

Halle Sobel, MD

• Immediate Past-President, New England Chapter of Society of General Internal Medicine

Sarah Bushweller, PA • Board of Directors for the Physician Assistant Academy of Vermont • Vermont representative to the House of Delegates, American Academy of

Physician Assistants

Dennis Beatty, MD • AAMC Council of Faculty and Academic Societies, Senior Representative from

Larner College of Medicine Editorships and Editorial Boards: Halle Sobel, MD

• Reviewer: Annals of Internal Medicine, AAIM, SGIM, JGIM, AJM Study Sections and Federal Advisory Boards: Patricia King, MD, PhD

• Federation of State Medical Boards Advisory Council to the United States Medical Licensing Examination

• National Board of Medical Examiners Standards Setting Committee for USMLE Step 1

Major Faculty Awards:

• Bloomfield Early Career Professorship in Cardiovascular Research- Timothy Plante, MD, MHS

• Distinguished Educator, LCOM Teaching Academy- Halle Sobel, MD

Grants

Halle Sobel, MD SAMSHA grant Grant Number: 1 H79 TI082571-01 Project Title: Increasing the Pipeline of MAT Prescribers: DATA Waiver Training

for All Vermont Medical Students at The Larner College of Medicine

Benjamin Littenberg, MD, Richard Pinckney, MD (co-investigators) PCS-1409-24372. Integrating Behavioral Health and Primary Care for Co-Morbid Behavioral and Medical Problems. Total Direct Costs: $18, 523, 145.

Emily Hadley Strout, MD, Elizabeth Wahlberg, MD UHC Fund Grant: Integration of Mentorship and At the Elbow Support for Panel Management in an IM Resident Clinic

Timothy Plante, MD (primary investigator)

Loan Repayment Award (Plante) 10/1/2020-9/30/2022 0 Cal. mo. NIH-NHLBI $92,811 Loan Repayment Award for project “The inflammatory basis of hypertension” As with the career development award above, this project will assess the role of inflammation on the development of hypertension. This proposal will provide significant renumeration for loan repayment to support these efforts. Role: PI

Bloomfield Early Career Professor in Cardiovascular Research

7/1/2020 – 6/30/2022 0.6 Cal. mo.

UVM $150,000 The inflammatory basis of hypertension This named professorship provides funds to augment the planned K08 application, The inflammatory basis of hypertension. This project will extend on the existing REGARDS infrastructure to assess the role of novel inflammatory biomarkers in the development of hypertension. Role: PI

Timothy Plante, MD as co-investigator:

6 NU38OT000280-03-02 (Zakai) 9/01/2020 – 7/30/2021 0.6 Cal. mo. CDC $1,400,000

Understanding risk factors and burden of COVID-19 related thrombosis and or bleeding complications High rates of thrombosis and bleeding have been reported in hospitalized COVID-19 patients leading to clinical uncertainty as to the benefit of anticoagulation. Pooling data from 9 hospital systems and over 10,000 hospitalized COVID-19 patients, we will determine the absolute and relative

rates of thrombosis and bleeding in COVID-19 patients as well as the association of antithrombotic medications with outcomes. Role: Co-investigator

R01HL141290 (Zakai) 5/15/2019 – 2/28/2023 1.44 Cal. mo. NIH/NHLBI $446,833 Thrombosis and Bleeding Risk Assessment in Medical Inpatients Our goals in two complementary healthcare systems (located at the University of Vermont and the University of Washington), are to develop and validate robust models to assess hospital-acquired bleeding and VTE risk, and determine the period of increased risk for bleeding and VTE after discharge from the hospital. With these aims, we will make healthcare safer by allowing providers to tailor VTE prevention strategies to those at highest risk of VTE and lowest risk of bleeding. Role: Co-investigator

U01NS041588 (Judd S; Howard G, Manley J, Cushman M,)

02/15/2018-03/31/2023 1.8 Cal. mo.

NIH - NINDS $441,530 VCID and Stroke in a Bi-Racial National Cohort Initiated in 2002, we are following 30,000 black and white adults for incident stroke, cognitive function, VCID and incident risk factors. We will study reasons for racial disparities in risk factor evolution over 10 years. I am a co-investigator and coordinate the reviews of new ancillary studies. Role: Co-investigator

Publications – peer reviewed, chapters, etc. (not abstracts)

• Gergi M, Cushman M, Littenberg B, Budd RC. Thrombo-inflammation response to Tocilizumab in COVID-19. Research and Practice in Thrombosis and Haemostasis 2020; 4:1262-8. DOI: 10.1002/rth2.12436

• Van den Broek-Altenbur EM, Atherly AJ, Diehl SA, Gleason KM, Hart VC, MacLean CD, Barkhuff DA, Levine MA, Carney JK. Jobs, Housing and Mask Wearing: Cross-Sectional Study of Risk Factors for COVID-19. JMIR Public Health Surveill. 2021 Jan 11;7 (1)

• Plante TB, Koh I, Judd SE, Howard G, Howard VJ, Zakai NA, Booth JN 3rd, Safford M, Muntner P, Cushman M. Life’s Simple 7 and Incident Hypertension: The REasons for Geographic and Racial Differences in Stroke (REGARDS) Study. J. Am. Heart Assoc. 2020; 9(19):e016482. PMCID: PMC7261502.

• Miller HN, Charleston J, Wu B, Gleason K, Dennison Himmelfarb CR, Ford DE, Plante TB, Gelber AC, Appel LJ, Miller EP 3rd, Juraschek SP. Use of electronic recruitment methods in a clinical trial of adults with gout. Clinical Trials. 2020. Sep 15:1740774520956969. PMID: 32933342

• Appel LJ, Michos ED, Mitchell CM, Blackford AL, Sternberg AL, Miller ER III, Juraschek SP, Schrack JA, Szanton SL, Charleston J, Minotti M, Baksh SN, Christenson RH, Coresh J, Drye LT, Guralnik JM, Kalyani RR, Plante TB, Shade DM, Roth DL, and Tonascia J for the STURDY Collaborative Research Group. The Effects of Four Doses of Vitamin D Supplements on Falls in Older Adults: A Response-Adaptive, Randomized Clinical Trial. Ann Intern Med. 2020. E-pub Dec 8 2020. PMID: 33284677.

• Plante TB, Blau AM, Berg AN, Weinberg AS, Jun IC, Tapson VF, Kanigan TS, Adib AB. Development and External Validation of a Machine Learning Tool to Rule Out COVID-19 Among Adults in the Emergency Department Using Routine Blood Tests: A Large, Multicenter, Real-World Study. J Med Internet Res 2020;22(12):e24048. PMCID: PMC7713695

• Plante TB, Long DL, Guo B, Howard G, Carson AP, Howard VJ, Judd SE, Jenny NS, Zakai NA, Cushman M. Elevated C-reactive protein and differences in hypertension incidence between black and white Americans: The REasons for Geographic And Racial Differences in Stroke (REGARDS) study. Am J Hypertension. 2020. E-pub Dec 16, 2020. PMID: 33326556.

• Nicoli CD, Plante TB, Long DL, Judd SE, McClure LA, Arora P, Cushman M. N-Terminal Pro-B-Type Natriuretic Peptide and Longitudinal Risk of Hypertension. American Journal of Hypertension. E-published Dec 30,2020. PMID: 33378421.

• Integrating Addiction Medicine into Undergraduate Medical Education: The

Time is Now. E Riser, LA Holterman, S Maruti, JR Brooklyn, SG Devoe, BJ Tompkins, J Drouin and HG Sobel. Substance Abuse, 1-8, 2021 Apr 06

• Crocker AM, Kessler R, van Eeghen C, et al. Integrating Behavioral Health and Primary Care (IBH-PC) to improve patient-centered outcomes in adults with multiple chronic medical and behavioral health conditions: study protocol for a pragmatic cluster-randomized control trial. Trials. 2021; 22, 200. https://doi.org/10.1186/s13063-021-05133-8

• Ramos-Nino ME, MacLean CD, Littenberg B. Association between prevalence of obstructive lung disease and obesity: results from the Vermont Diabetes Information System. Asthma Research and Practice 2021; 7:6. https://doi.org/10.1186/s40733-021-00073-1

• Ramos-Nino ME, MacLean CD, Littenberg B. Association between Obstructive Lung Disease and Cardiovascular Disease: Results from the Vermont Diabetes Information System. Journal of Respiration. 2021;1: 165-72. https://www.mdpi.com/2673-527X/1/3/16

• Oleng N.A., Sobel H.G., Kwolek D. Cervical Cancer and Human Papillomavirus: Prevention and Screening. Eds. Tilstra SA, Kwolek D, Mitchell JL, Dolan BM. Carson MP, Sex- and Gender-Based Women's Health. Springer, Cham. https://doi.org/10.1007/978-3-030-50695-7_14

• Twist K.E., Sobel H.G. (2020) Urinary Incontinence. Eds. Tilstra SA, Kwolek D, Mitchell JL, Dolan BM. Carson MP. Sex- and Gender-Based Women's Health. Springer, Cham. https://doi.org/10.1007/978-3-030-50695-7_23

• Colantonio L, Reynolds R, Merriman T, Gaffo A, Singh J, Plante TB, Soliman E, Curtis J, Bridges S, Howard G, Safford M, Saag K, Muntner P, Irvin M. Higher serum urate levels are associated with an increased risk for sudden cardiac death in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study. Journal of Rheumatology. 2021. In press.

• Nicoli CD, Carson AP, Plante TB, Long DL, McClure LA, Schulte J, Cushman M. Pro-Neurotensin/Neuromedin N and Risk of Incident Metabolic Syndrome and Diabetes Mellitus in the REGARDS Cohort. J Clin Endocrinol Metab. 2021. In press.

• Harder VS, Varni SE, Murray KA, Plante TB, Villanti AC, Wolfson DL, Maruti S, Fairfield KM. Prescription Opioid Policies and Associations with Opioid Overdose and Related Adverse Effects. International Journal of Drug Policy. 2021. In press.

• Munger JA, Koh I, Howard G, Howard V, Plante TB, Wilkinson K, Cushman M, Zakai NA. Television viewing, physical activity and venous thromboembolism risk: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study. J Thromb Haemost. 2021 Jun 2. doi: 10.1111/jth.15408. Epub ahead of print. PMID: 34077616.

• Colantonio L, Reynolds R, Merriman T, Gaffo A, Singh J, Plante TB, Soliman E, Curtis J, Bridges S, Howard G, Safford M, Saag K, Muntner P, Irvin M. Higher serum urate levels are associated with an increased risk for sudden cardiac death in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study. Journal of Rheumatology. 2021. In press.

• Prasanna A, Miller HN, Wu Y, Peeler A, Ogungbe O, Plante TB, Juraschek SP. Recruitment of Black adults into cardiovascular disease trials. J Am Heart Assoc. 2021. In press.

• Harder VS, Plante TB, Koh I, Rogers EB, Varni SE, Villanti AC, Brooklyn JR, Fairfield KM. Influence of opioid prescription policy on overdoses and related adverse effects in a primary care population. J Gen Intern Med. 2021. In Press. DOI: 10.1007/s11606-021-06831-4

• van den Broek-Altenburg EM and Atherly AJ “Adherence to COVID-19 Policy Measures:Behavioral Insights from The Netherlands and Belgium”. PLOS One. May 28, 2021 https://doi.org/10.1371/journal.pone.0250302

• Atherly, A., van den Broek-Altenburg, E., Leffler, S and Deschamps, C.

“Despite Early Success, Vermont’s All-Payer Waiver Faces Persistent Implementation Challenges: Lessons From The First Four Years” Health Affairs Blog. January 5, 2021. https://www.healthaffairs.org/do/10.1377/hblog20201222.153835/full

• Haddad, Y.K., Luo, F., Bergen, G., Legha, J.K., Atherly, A. Antidepressant

subclass Use and Fall Risk in Community-Dwelling Older Americans. Journal of Safety Research. Vol 76; Feb 2021; 332-340; doi.org/10.1016/j.jsr.2020.11.008

• van den Broek-Altenburg EM, Atherly AJ, Diehl SA, Gleason KM, Hart VC,

MacLean CD, Barkhuff DA, Levine MA, Carney JK “Jobs, Housing and Mask-Wearing: A Cross-Sectional Study of Risk Factors for COVID-19” JMIR Public Health and Surveillance. 2021;7(1):e24320; DOI: 10.2196/24320 URL: https:// preprints.jmir.org/preprint/24320

• Lester-Coll NH, Ades S, Yu JB, Atherly A, Wallace HJ, Sprague BL. Cost-effectiveness of Prostate Radiation Therapy for Men With Newly Diagnosed Low-Burden Metastatic Prostate Cancer. JAMA Network Open. 2021;4(1):e2033787. doi:10.1001/jamanetworkopen.2020.33787

• Sheahan K., Atherly, A., Dayman, C and Schnure, J. “The Impact of

Diabetology Consultations on Length of Stay in Hospitalized Patients with Diabetes". Endocrinology, Diabetes & Metabolism Jan 2021 ;4(1): e00199. https://doi.org/10.1002/edm2.199

• Atherly, A., van den Broek-Altenburg, E., Hart, V. Gleason, K and Carney, J. “Consumer Reported Care Deferrals Due to the COVID-19 Pandemic, and the Role and Potential of Telemedicine: Cross-Sectional Analysis” Journal of Medical Internet Research: Public Health & Surveillance 2020;6(3):e21607 doi: 10.2196/21607

• Gyllstrom, B., McCoy, M., Pezzino, G and Atherly, A. “Leveraging limited resources through cross-jurisdictional sharing: Effects on breastfeeding rates” Journal of Human Lactation.. 2020 Oct 8: 0890334420963638.

• van den Broek-Altenburg, E., Atherly, A. “Using discrete choice experiments to measure preferences for hard to observe choice attributes to inform health policy decisions.” Health Econ Rev 10, 18 (2020). https://doi.org/10.1186/s13561-020-00276-x

• Meyers, M and Atherly, A. "The Effect of Medicaid Accountable Care Collaborative on 30-Day Hospital Readmission Rates" Population Health Management Martha L. 2021 Apr 1;24(2):190-7. doi.org/10.1089/pop.2019.0241

• Yingbo, L, Atherly, A. Johnson, T., Anderson, M. Valdez, C and Sabalot, S. “The

impact of care management for high-risk pediatric asthmatics on healthcare utilization” Journal of Asthma. 2021 Jan 2;58(1):133-40.DOI: 10.1080/02770903.2019.1659311.

• van den Broek-Altenburg, E and Atherly, A. “Patient Preferences for Provider

Choice: A Discrete Choice Experiment” American Journal of Managed Care 2020 Jul 1;26(7):219-24.

Geriatric Medicine Michael LaMantia, MD, Division Chief https://www.med.uvm.edu/medicine/geriatrics

The Division of Geriatric Medicine specializes in providing world-class, personalized medical care to older adults in a variety of settings, including nursing homes, rehabilitation facilities, clinics, and patient homes. We strive to get to know our patients as individuals and recognize the important role that their family, friends, caregivers, and community play in their identity and in their care. We are excited to work with our colleagues across Vermont and Northern New York State to ensure that our area

remains one of the best places in the country to age in place. Our faculty physicians teach geriatric medicine to medical students, resident physicians, professional colleagues, and community members. We hold numerous leadership roles at the College of Medicine and are proud to serve an integral role in our vibrant academic medical center. Service: Our 7 physicians and 2 nurse practitioners care for many geriatric patients in Chittenden County, attending to elderly patients living independently, in assisted living, in local nursing homes, and at hospice. Our Geriatric Medicine Division does consultations for the care of older adults through our Adult Primary Care Williston location. Education: Our geriatricians play a key role in teaching medical students, residents, undergraduates, graduate students, and providers across the region in issues affecting older adults. In addition, we speak widely on topics in aging in public venues across the region; we are interviewed frequently by newspaper and television reporters on the subject; and we provide evidence-based guidance to partners in community organizations as well as local and state government. We teach the following groups of learners at the University of Vermont and University of Vermont Medical Center: Undergraduate Students: Our faculty frequently teach in courses at the undergraduate level, often in courses led by our colleagues in the University of Vermont Center on Aging. In addition, our partners at the Center on Aging frequently work with us to find mentor and volunteer experiences for undergraduates interested in experiences in aging.

Medical Students: We teach medical students in the Doctoring in Vermont Course, the second-year Human Development and Reproductive Health Course, in clerkships, and in special electives. Medical Residents: All internal medicine residents complete a required rotation in geriatric medicine where they evaluate patients in a variety of care settings under the supervision of our faculty. Graduate Students: Our faculty have offered seminar courses in the Graduate College on topics related to aging through the Clinical and Translational Sciences program. Research Our faculty conduct research on a wide variety of topics affecting older adults in partnership with and with the support of the University of Vermont Center on Aging. Particular areas of focus include care of patients with cognitive impairment including delirium and dementia, care of older adults with chronic kidney disease, and care of older adults in the emergency department. Faculty - Geriatric Medicine Zail Berry, MD Associate Professor of Medicine Medical Director, The Arbors

• Geriatric Medicine • Key Research Area: Optimizing care of elders in long-term care facilities

Amelia Gennari, MD Associate Professor of Medicine Associate Chief for Clinical Affairs

• Geriatric Medicine Elizabeth Rosy Hill, MD Assistant Professor of Medicine Medical Director of Green Mountain Nursing Facility

• Geriatric Medicine Michael LaMantia, MD Associate Professor of Medicine

• Chief, Division of Geriatric Medicine • Holly and Bob Miller Chair of Memory and Aging • Director, University of Vermont Center on Aging

Isaura Menzies, MD Associate Professor of Medicine Associate Chief for Education Medical Director, Elderwood at Burlington Nursing Home

• Geriatric Medicine Alexandra Messerli, MD Assistant Professor of Medicine

• Geriatric Medicine Susanna Thach, MD Assistant Professor of Medicine

• Geriatric Medicine Nurse Practitioners, Physician Assistants, and Mental Health Specialists: Birchwood Nursing Center (Skilled Nursing Facility) Amber Snow, NP Elderwood at Burlington Nursing Home (Skilled Nursing Facility) Elisa Vautier, NP Publications – peer reviewed, chapters, etc. (not abstracts)

1. Cheung KL, Tamura MK, Stapleton RD, Rabinowitz T, LaMantia MA, Gramling R. Feasibility and acceptability of telemedicine-facilitated palliative care consultations in rural dialysis units. Journal of Palliative Medicine. January 2021.

2. Kennedy MA, Pepin R, Stevens CJ, Bartels SJ, Batsis JA, Beyea A, Bruce ML, Eckhaus JM, Korsen N, Pidgeon DM, Powell KE, Reynolds CF, LaMantia MA. Mind, Mood, Mobility: Supporting Independence Among Rural Older Adults at Risk for Functional Decline. American Journal of Health Promotion. 2021: 35 (2), 295-298.

3. Kenned MA, Hatchell KE, DiMilia PR, Kelly SM, Blunt HB, Bagley PJ, LaMantia MA, Reynolds II, CF, Crow RS, Maden TN, Kelly SL, Kihwele JM, Batsis JA. Community health worker interventions for older adults with complex health needs: A systematic review. Journal of the American Geriatrics Society. 2021: 69(6): 1670-1682.

http://www.uvm.edu/medicine/medicine/hemonc/

A. Executive Summary

The Division of Hematology and Oncology has had a successful clinical and academic year. The division has 18 faculty members located at the UVMMC campus with additional faculty members at CVMC (2), Porter Medical Center (1) and CVPH (1). Faculty in the division care for patients with oncologic and hematologic malignancies, benign hematology, as well as thrombotic and bleeding disorders. We were fortunate to have Dr. Jaqueline Poston join us this spring as a new faculty member focused on benign hematology. In addition, Drs. Holmes and Zakai were promoted to full professor with tenure. Several faculty also received awards including Dr. Zakai (Department of Medicine Mentor Award); Dr. Dittus (Department of Medicine Distinguished Clinician Award); Dr. Adrianzen-Herrera (CVRI Young Investigator as well as the ASH Clinical Research Training Institute Award); Dr. Cushman (Gender Equity Outstanding Achievement in Medicine LCOM, Meritorious Achievement Award from the American Heart Association, and induction into the Association of American Physicians).

Several members of the faculty were appointed to new leadership positions this year- highlights include: Dr. Cushman, Vice Chair for Emerging Research DOM; Dr. Ahmed (TDT leader-GU-UVM CC, beginning October 2021); Dr. Barry (TDT leader H&N UVM CC); Dr. Dittus (new Director of Integrative and supportive Services UVM CC); Dr. Wood (Deputy Director, Cancer Control Program- ALLIANCE for clinical trials); Dr. Khan (Medical Director of the HemOnc Clinic) and Dr. Kaufman (3 year term, ALLIANCE Board of Directors). In addition to these new positions, faculty continued to hold other key leadership position in the UVM Cancer Center including Dr. Holmes (interim Co-Director); Dr. Wood (Associate Director Cancer Control and Population Health Sciences Program), Dr. Ades (Medical Director of the Clinical Trial Office); Dr. Greenblatt (Molecular Mechanisms of Malignancy Program Co-Leader) and Dr. Kaufman (Co-leader of the Host Factor and Tumor Progression Program). Dr. Cushman continued to serve on the Board of Directors of the Cardiovascular Research Institute at the University of Vermont and Dr. Barry

serves as a member of the Education and Professional Development Working Group, LCOM Gender Equity Initiative. The clinical care enterprise is comprised of faculty, 6 APPs, 3 genetic counselors and over 50 nurses and staff in the outpatient UVMMC clinic. In 2020-2021 the division provided over 22321 outpatient visits, 3214 new patients visits in addition to 11,270 infusions and 352 procedures (at the UVMMC campus). Inpatient services offered by the division include a hematology consult service, an oncology consult service and a heme-malignancy inpatient service. In addition to specialized hematology services and subspecialty oncologic care, the division also provides unique services to our patient population including:

• The Thrombosis & Hemostasis Program, (Dr. Cushman, Director) • Multidisciplinary Oncology Clinics (in collaboration with surgery & radiation oncology) • The Apheresis Program, (Dr. Sprague, Director) • The VT Regional Hemophilia Treatment Center (federal designation, Dr. Holmes, PI) • The FACT accredited Autologous Stem Cell Transplant Program (Dr. Sprague, Director) • The High Risk Breast Program, a clinical research program, (Dr. Wood, PI) • Familial Cancer Genetics, (Drs. Wood and Greenblatt, PI’s with 3 cancer geneticists) • Oncology Rehabilitation, (Dr. Dittus, Medical Director) • Lymphedema Care and Expertise, (Dr. O’Brien, PI) • The Prevention of Cancer Associated Thrombosis Program (Dr. Holmes PI)

Research within the division focuses on epidemiologic and translational research as well as clinical trials. Despite the challenges of COVID and the cyberattack, 10 new grants were funded with Hematology/Oncology faculty serving as the PIs including an NCI U24 (Greenblatt); 1 CDC grant (Zakai); 5 NNECOS awards (Ades, Ahmed, Rehman, Adrianzen-Herrera, Wood), 1 UVM Cancer Center award (Wood); 1 NNECTR (Holmes); 1 collaborative grant with the Vermont State Department of Health (Dittus). Investigators within the Division receive funding from clinical trials (national cooperative group and pharmaceutical trials), NIH NCI, NHLBI, and AHA. The division faculty and fellows published 82 manuscripts in the last year and were involved in numerous local, national and international abstract presentations. A highlight for the division was the preparation and publication of a manuscript in Journal of Oncology Practice (JCOP) titled “Cancer Care in the Wake of a Cyberattack: How to Prepare and What to Expect”.

The division also maintains an active fellowship program comprised of 6 fellows under the direction of Dr. Julian Sprague (Program Director) and Dr. Molly Barry (Associate Program Director). Specialized tracks in thrombosis & hemostasis, familial genetics and breast cancer are available to fellows and promote the academic careers of interested fellows. Fellows maintain an active clinical schedule and are engaged in research. Division highlights in education include Dr. Molly Barry was accepted in to the ASCO Education Scholars Program and Dr. Sakshi Jasra participated in the Teaching Academy’s Medical Education Fellowship.

Faculty Jose Acostamadiedo, MD-Clinical Practice Physician Physician at CVPH Research and clinical interests: Lung Cancer and Melanoma Steven Ades, MD, MSc – Associate Professor Leader, UVM Medical Upper Gastrointestinal Oncology Transdisciplinary Team

Co-Leader, UVM Medical Center Genitourinary Oncology Transdisciplinary Team Medical Director, UVM Cancer Center Clinical Trials Office Member, University of Vermont Cancer Center Clinical Trials Executive Committee Member, University of Vermont Cancer Center Protocol Review and Monitoring Committee Member, University of Vermont Medical Center Cancer Service Line Leader Committee Member, UVM Medical Center Hematology/Oncology Fellowship Program Evaluation Committee Member, UVM Medical Center Hematology/Oncology Fellowship Clinical Competency Committee Research and clinical interests: GI and GU cancers, supportive care and thrombosis in malignancy

Diego Adrianzen Herrera, MD-Assistant Professor Member, Protocol Review and Monitoring Committee, UVM Cancer Center Member, Search Committee, Malignant Hematology Clinical Scholar Pathway

Member, Search Committee, Hematopathologist, Clinical Scholar Pathway Member, Grand Rounds Committee, Division of Hematology and Oncology Member, Hematology/Oncology Fellowship Applicant Review and Interview Committee

Research and clinical interests: Clinical correlation and epidemiologic significance of clonal hematopoiesis, myelodysplastic syndrome and cardiovascular disease. Novel diagnostic, therapeutic or prognostic markers in acute myeloid leukemia. Developing and implementing a portfolio of clinical trials in malignant hematology at UVM

Shahid Ahmed, MD, MBBS-Assistant Professor

Member - University of Vermont Cancer Center Member - UVMMC Protocol Review and Monitoring Committee (PRMC) Member - UVM Health Network Covid-19 Hematology/Oncology Re-entry committee Member - UVMMC Hematology/Oncology Grand Rounds Committee Leader - Genitourinary Oncology Transdisciplinary team (starting October 2021) Member - Cutaneous oncology Transdisciplinary team Research and clinical interests: Clinical trials in genitourinary and cutaneous malignancies. Interplay of microbiome and T cells in bladder cancer

Maura (Molly) Barry, MD-Assistant Professor Associate Program Director, Hematology/Oncology Fellowship Program Member, UVMMC Department of Medicine Faculty Development Committee, Member, UVM Medical Center Hematology/Oncology Fellowship Program Evaluation Committee

Member, UVM Internal Medicine Residency Program Evaluation Committee Member, UVM Medical Center Hematology/Oncology Fellowship Clinical Competency Committee

Member, Larner College of Medicine Committee on Fitness Member, Larner College of Medicine Teaching Academy Member, UVM Medical Center EPIC Advisory Council Member, UVM Medical Center EPIC Oncology Power Team EPIC Specialty Champion Member, Education and Professional Development Working Group, LCOM Gender Equity Initiative Member, LCME Self-Study Task Force, Subcommittee 9 Leader, Head and Neck TDT, UVM Cancer Center Research and clinical interests: Medical Education GI and head and neck cancers, supportive care, wellness.

Mary Cushman, MD, MSc – Professor and Vice Chair for Emerging Researchers, Medicine. Professor of Pathology Director, Thrombosis and Hemostasis Program Board Member, Cardiovascular Research Institute Vice Chair, Emerging Researchers, Department of Medicine

Research and clinical interests: Etiology of cardiovascular diseases, stroke, cognitive impairment and other chronic diseases; racial disparities; venous thrombosis and post thrombotic syndrome, COVID-19

Kim Dittus, MD, PhD – Associate Professor Medical Director of Oncology Rehabilitation Director, Inpatient Hematology/Oncology Chair Clinical Committee, Program in Integrative Health

Member, Cancer Control Committee, Chair of survivorship subcommittee UVM Medical Center Director, Integrative and Supportive Services, UVM Cancer Center Research and Clinical interests: Breast Cancer, Cancer survivorship, diet/nutrition, exercise

Marc Greenblatt, MD – Professor Co-Chair, UVM Cancer Center Molecular Mechanisms of Malignancy Program Assistant Director, Hematology/Oncology Fellowship Program

Member, UVMCC-Hem-Onc Grand Rounds

Research and clinical interests: Cancer genetics and gastrointestinal cancers

Chris Holmes, MD, PhD – Professor of Medicine Interim Division Chief, Hematology/Oncology Division Interim Co-Director, University of Vermont Cancer Center Director, Vermont Regional Hemophilia Treatment Center Assistant Director, Thrombosis and Hemostasis Program Leader, Clinical Trials Executive Committee, UVM Cancer Center

Research and clinical interests: Venous thrombosis, platelet function, coagulation and cancer

Sakshi Jasra, MD—Assistant Professor

Co-chair, UVM Department of Hematology/Oncology Grand Rounds Committee Member, UVM Cancer Center Data Safety and Monitoring Board Member, UVM Department of Medicine Operations Committee Research and clinical interests: Exploring barriers to clinical trial enrollment in rural cancer patients, qualitative research methods and their applications in rural health and mechanisms and clinical relevance of clonal hematopoiesis

Peter Kaufman, MD – Professor Member, Vermont Cancer Center Data Safety and Monitoring Committee (DSMC) Director, Regional Clinical Trials, Vermont Cancer Center

Program Co-Leader, Host Factors and Tumor Progression (HFTP) Vermont Cancer Center Member, Clinical Trials Executive Committee, Vermont Cancer Center Member, Neuro-Oncology Search Committee Member, search committee, UVM Cancer Center Director and Hematology/Oncology Division Chief Research and clinical interests: Breast cancer, translational research in breast cancer, clinical research and clinical trials in breast cancer

Farrah Khan, MD – Assistant Professor

Member: UVMMC Department of Medicine Faculty Development Committee, Faculty Engagement Committee Member, UVMMC Department of Medicine Quality Assurance and Improvement Committee Member, Data Safety and Monitoring Committee, UVM Cancer Center Member, Executive Board for the Pharmacy and Therapeutics Committee Medical Director, Hematology and Oncology Clinic

Research and clinical interests: Lung cancer, breast cancer, mesothelioma, sarcoma and supportive/palliative care

Saranya Kodali, MD—Clinical Practice Physician Physician at CVMC Member, Faculty Development Committee at UVMMC Research and clinical interests: Malignant Hematology Patricia O’Brien, MD – Assistant Professor Clinical Scholar Director, Lymphedema Program Oncology Rehab-Steps to Wellness Jacqueline Poston, MD – Assistant Professor Hematology/Oncology Division, Department of Medicine Transfusion Medicine, Clinical Pathology Division, Department of Pathology Director, Anticoagulation Safety

Research and clinical interests: Acquired hemophilia A, intersection of hematology and immunology, benign hematology

Hibba tul Rehman, MD—Assistant Professor Member, Protocol Review and Monitoring Committee Member, Clinical Competency Committee for Hem/Onc Fellowship Member, Program Evaluation Committee for Hem/Onc Fellowship Member, UVMMC Credentials Committee

Research and clinical interests: Lung cancer, sarcoma, breast cancer and rare tumors Julian Sprague, MD, PhD – Associate Professor Director, Hematology/Oncology Fellowship Program Director, Stem Cell Transplant Program, University of Vermont Medical Center Clinical Director, Apheresis Services Member, UVM Medical Center, Transfusion Committee Member, UVM Medical Center, Ethics Committee

Research and clinical interests: Myeloma and neurotoxicity, hematologic malignancies Eswar Tipirneni, MD—Clinical Practice Physician Medical Director, CVMC Hematology/Oncology Research and clinical interests: Immunotherapy and lung cancer Elvira Umyarova, MD—Assistant Professor

Chair, UVM Pharmacy, Chemotherapy Subcommittee

Member, UVM Fellowship Committee Assistant Director, Stem Cell Transplant Program, University of Vermont Medical Center Research and clinical interests: Malignant hematology, stem cell transplant, clinical trials

Paul Unger, MD, FACP—Associate Professor Site Leader, Community Oncology Porter Chair, UVMMC Credential Committee

Research and clinical interests: Quality assessment for clinical oncology in community practice

Marie Wood, MD – Professor Director, Familial Cancer Program Assistant Director, Hematology/Oncology Division Associate Director, Cancer Control and Population Health Science

Co-Chair, University of Vermont Faculty Senate Educational and Research Technologies Committee Member, Executive Committee Faculty Senate Research and clinical interests: Biomarkers of breast cancer risk, genetic testing in rural areas, breast cancer screening and prevention

Neil Zakai, MD, MSc – Professor of Medicine and Pathology

Member (Past Chair), UVM Cancer Center Data Safety and Monitoring Board Member, UVM Medical Center Pharmacy and Therapeutics Committee Member, UVM Medical Center Hematology/Oncology Fellowship Research Committee Member, UVM Medical Center Internal Medicine Residency Research Committee Chair, Medication Safety Subcommittee for the Pharmacy & Therapeutics Committee Research and clinical interests: Epidemiology and novel risk factors for venous thrombosis and cardiovascular disease. Epidemiology, causes, and consequences of anemia in diverse populations. Venous thrombosis causes and prevention, post thrombotic syndrome.

Hematology/Oncology Fellows Ximena JordanBruno, MD—3rd year fellow Sarah Gillett—3rd year fellow Kara Landry, MD—2nd year fellow Mansour Gergi, MD—2nd,year fellow Anil Rahul, MD—1st year fellow Asad Anwar, MD—1st year fellow NP’s and PA’s Jamie Kelly, PA

Penny Gibson, PA Jordan Tolstoi, PA Anne Berkowitz, NP Janet Ely, NP Emily Parenteau, MSN, FNP Graduate students, post-doctoral fellows, MD PHD students

Juan Conde, PhD. MD Candidate. Smoking, Biomarkers and Stroke Risk. Medical Student Research. Mentored by Mary Cushman Debora Kamin Mukaz, PhD. Post-doctoral associate. Mechanisms of racial disparities in diabetes and hypertension incidence affecting African-Americans. Mentored by Mary Cushman Samuel Short, BA. MD Candidate. Proenkephalin and risk of stroke and cognitive impairment in a biracial cohort. Medical Student Research. UVM Cardiovascular Research Institute of Vermont (CVRI) Summer Research Award 2020. Mentored by Mary Cushman Alexander Karabachev, UVM LCOM Class of 2021 Mentored by Marc Greenblatt Maeve Dillon-Martin, UVM Class of 2022 Mentored by Marc Greenblatt Cinduja Nathan-Medical Student Research. Venous thromboembolism prevention in the ambulatory cancer clinic (VTE PACC). Mentored by Chris Holmes Kara Landry, MD Mentored by Marie Wood Nick Farina, PhD Mentored by Marie Wood Alexander Karabachev, Mentored by Marc Greenblatt Jordan Munger, BS: Inaugural Dean’s research fellowship 2020-21. Mentored by Neil Zakai

Leadership in Professional Societies Jose Acostamadiedo, MD

Cancer Liaison Physician for Fitzpatrick Cancer Center Steven Ades, MD

Member, Board of Directors Northern New England Clinical Oncology Society Member, Alliance Symptom Intervention Committee Member, ASCO Upper Gastrointestinal Oncology Annual Meeting Planning Committee

Diego Adrianzen Herrera, MD

Member, American Society of Clinical Oncology (ASCO): Career Conversations Mentor, Trainee and Early Career Council. Member, Northern New England Clinical Oncology Society (NNECOS): Grant Reviewer Committee

Shahid Ahmed, MD, MBBS

Member, ALLIANCE Cooperative Group Immuno-Oncology Committee Member, NNECOS Grant Review Committee

Member, American Society of Clinical Oncology Member, American Society of Hematology Member, Northern New England Clinical Oncology Society

Associate – Mednet Melanoma expert panel - Mednet

Maura Barry, MD Member, American Society of Clinical Oncology Member, Northern New England Clinical Oncology Society Member, Multinational Association of Supportive Care in Cancer

Member, ASCO eLearn Question Writing Group

Mary Cushman, MD, MSc Member, Media Experts Committee, American Society of Hematology

Member, Leadership Council of the International Society on Thrombosis and Haemostasis, ex officio non-voting Publishing Committee (ex officio), International Society on Thrombosis and Hemostasis Medical Advisory Committee, Foundation for Women & Girls with Blood Disorders Planning Committee, 2021 HTRS Research Colloquium, Developing a Sustainable Research Career in Hemostasis and Thrombosis Chair, Subcommittee on Women in Science and Medicine, American Heart Association Chair, 2020 Women’s Triennial Health Tracking Study in Cardiovascular Disease and Stroke. American Heart Association Board Director, Hemostasis and Thrombosis Research Society Board Director, Eastern States Affiliate, American Heart Association Research Funding Subcommittee of the Research Committee, American Heart Association Member, Medical Alumni Executive Committee Vascular Health Advisory Committee, American Heart Association

Kim Dittus, MD, PhD Member, Cancer Control Committee, UVM Medical Center Member, Northern New England Clinical Oncology Society Marc Greenblatt, MD President, Human Genome Variation Society (HGVS) Executive Board, Human Genome Organization (HUGO)

Co-Chair, InSiGHT-ClinGen Hereditary Polyposis Colorectal Cancer APC Gene Variant Curation Expert Panel Member, ClinGen Sequence Variant Interpretation Working Group; Co-Chair, Computational Subgroup Member, International Scientific Advisory Council, Human Variome Project Member, American Association of Cancer Research

Member, American Society of Clinical Oncology Member, American Society of Human Genetics Member, Collaborative Group of the Americas of Inherited Colorectal Cancer (CGA-ICC) Member, Vermont Medical Society Member, Northern New England Clinical Oncology Society

Chris Holmes, MD, PhD

Executive Board Member, National Network, Health and Human Services New England Comprehensive Hemophilia Diagnostic and Treatment Centers Director, Community Counts-Vermont, Centers for Disease Control (CDC) Public Health Monitoring Program, Division of Blood Disorders Member, Institutional Review Board, Committee on Human Research in the Medical Sciences (CHRMS), University of Vermont Member, American Society of Hematology Member, Northern New England Clinical Oncology Society Member, Thrombosis Committee, American Thrombosis and Hemostasis Network, Centers for Disease Control Member, Northern New England Clinical Oncology Society

Sakshi Jasra, MD Member, American Society of Hematology Member, Northern New England Clinical Oncology Society Peter Kaufman, MD

Committee Member, Breast Cancer Core Committee, Alliance for Clinical Trials in Oncology Breast Cancer Committee Liaison to Neuro-Oncology, Alliance for Clinical Trials in Oncology Alliance Champion, E2112, A Randomized Phase III Trial of Endocrine Therapy Plus Entinostat or Placebo in Patients with Hormone Receptor Positive Advanced Breast Cancer Co-Investigator, A071701, Genomically Guided Trial in Brain Metastases (CTEP Approved)

Member, Board of Directors, Alliance for Clinical Trials in Oncology Member, Macrogenics ODAC Preparation Committee, Preparation for Successful FDA ODAC Presentation. Member, Medical Advisory Board, Expedition Inspiration Fund for Breast Cancer Research, Boise, Idaho. Member, Northern New England Clinical Oncology Society

Farrah Khan, MD Member, American Society of Clinical Oncology Member, Northern New England Clinical Oncology Society Member, International Association for the Study of Lung Cancer Member, American Society of Clinical Oncology

Member, Alliance for Clinical Trials in Oncology Saranya Kodali, MD Member, Alliance for Clinical Trials in Oncology Member, NRG Oncology Member, American Society of Clinical Oncology Member, American Society of Hematology Member, American Society for Blood and Marrow Transplantation Member, American College of Physicians Member, Massachusetts Medical Society Member, Northern New England Clinical Oncology Society Patricia O’Brien, MD Member, American Physical Therapy Association- Oncology Rehabilitation Educational

Jacqueline Poston, MD Member, American Society of Hematology Member, AABB

Hibba tul Rehman, MD Member, American Society of Clinical Oncology Member, American Society of Hematology Member, Northern New England Strategic Planning Committee Member, Northern New England Educational Committee Member, Immuno Oncology Subcommittee for Alliance for Clinical Trials Julian Sprague, MD Member, American Society of Hematology Member, American Society of Clinical Oncology Member, Northern New England Clinical Oncology Society Member, Committee on Training, American Society of Hematology

Liaison, Committee on Quality from the Committee on Training, American Society of Hematology Member, Alliance Myeloma Subcommittee Chair, Medical Education Subcommittee for the Committee on Training (ASH)

Elvira Umyarova, MD Member, American Society of Hematology Member, Northern New England Clinical Oncology Society

Member American Society of Clinical Oncology Paul Unger, MD Immediate Past President, Northern New England Oncology Society

Member, American Society of Clinical Oncology Quality Oncology Project Initiative (QOPI) Steering Committee

Member, Clinical Practice Committee of ASCO

Marie Wood, MD Co-Chair, Alliance, Prevention Committee

Deputy Director, Alliance Cancer Control Committee Member, Alliance Foundation, Board of Trustees Member, Northern New England Clinical Oncology Society Board of Directors President, Northern New England Clinical Oncology Society Member, American College of Physicians Member, National Surgical Adjuvant Breast and Bowel Project Member, NCI Cancer Prevention and Control Steering Committee Fellow, American Society of Clinical Oncology Fellow, American College of Physicians

Neil Zakai, MD American Heart Association (AHA)

Member, Executive Committee, American Heart Association Council on Epidemiology and Prevention Member (past chair), American Heart Association Council on Epidemiology and Prevention, Publications Committee American Heart Association Council on Epidemiology and Prevention March 2019 meeting (Houston TX)

American Society of Hematology (ASH) Member, American Society of Hematology COVID 19 research initiative on benign hematology. Member, American Society of Hematology “Consult a Colleague” Program-

• Content expert “Hemostasis/Thrombosis” • Content expert “Anemias”

Faculty, American Society of Hematology Clinical Research Training Institute (2016, 2017, 2018, 2019, 2020, 2021, 2022) Member 2019-2022, American Society of Hematology Organizing Committee for Highlights of ASH (organizing 12 domestic and 6 international meetings)

Hemophilia and Thrombosis Research Society (HTRS) • Vice-Chair 2020-2021 Mentored Research Award Committee • Mentored Research Award Grant Reviewer 2020-21, 2021-22

Member, Northern New England Clinical Oncology Society Editorships and Editorial Boards

Jose Acostamadiedo, MD Editorial Board Colombian Society of Hematology Oncology Magazine (ACHO) Shahid Ahmed, MD, MBBS Reviewer – Journal of Clinical Oncology, Precision Oncology Mary Cushman, MD

Inaugural Editor-in-Chief, Research and Practice in Thrombosis and Haemostasis Editorial Board, Circulation Marc Greenblatt, MD Contributing Editor, Human Mutation Peter Kaufman, MD Ad-Hoc Reviewer Journal of Immunology Ad-Hoc Reviewer American Journal of Hematology Ad-Hoc Reviewer Cancer Ad-Hoc Reviewer Journal of Clinical Oncology Ad-Hoc Reviewer Cancer Letters, British Journal of Cancer Ad-Hoc Reviewer Nature Publication Journals: Breast Cancer. Patricia O’Brien, MD Board, Multinational Association of Supportive Care in Cancer, reviewing lymphedema Publication Review for California Breast Cancer Research ProgramReview Grant Applications for Funding Marie Wood, MD Editorial Board, The Breast Editorial Board, Journal of the National Cancer Institute Editor in Chief, ASCO Digital Education Neil Zakai, MD Associate Editor, Research and Practice of Thrombosis and Haemostasis Study Sections and Federal Advisory Boards Mary Cushman, MD, MSc Steering Committee Member, NHLBI Collaborating Network of Networks for Evaluating COVID-19 and Therapeutic Strategies (CONNECTS)

Ad hoc reviewer. NIGMS Phase 1 Center of Biomedical Research Excellence (Chair, Lucy Liaw, PhD)

Chris Holmes, MD, PhD Center for Disease Control/American Thrombosis and Hemostasis Network Community Project Review Committee

Marie Wood, MD Member, NCI Cancer Prevention Steering Committee Member, Cancer, Heart and Sleep Epidemiology B Study Section Grants Steven Ades NNECOS Ades (PI) 01/15/20-06/16/21

VTE Risk Assessment and Prevention in Cancer Patients in the Community Oncology Setting

Role: PI PROMISE Trial Ades (PI) 01/01/19-12/31/20 UVMCC 1902-Prostate Cancer Circulating miRNAs for Precision-based Medicine Role: PI Diego Adrianzen-Herrera, MD Martin M. LeWinter Young Adrianzen-Herrera (PI) 12/2020 (Single Award)

Investigator Award Cardiovascular Research Institute of Vermont NNECOS Adrianzen-Herrera (PI) 04/01/21-04/01/22 Identifying factors associated with CV disease in MDS. An analysis of the Seer-Medicare database

Shahid Ahmed, MD, MBBS NNECOS Ahmed (PI)

How bacteria influence the formation of an immune escaped bladder cancer; a pilot correlative study

Mary Cushman

NINDS 02/15/18-01/31/23 U01 NS041588

VCID and Stroke in a Bi-Racial National Cohort S Judd, Contact PI, University of Alabama at Birmingham G Howard, MPI, University of Alabama at Birmingham J Manly, MPI Columbia University Role: MPI, 25% NHLBI 1/1/98– 3/31/24 R01 HL59367 Epidemiology of Venous Thrombosis and Pulmonary Embolism AR Folsom, PI, University of Minnesota Role: Subcontract PI, 15, 10, 10 in current project

NHLBI 08/15/00-12/18/25 HHSN2682015000031 Multiethnic Study of Atherosclerosis R. McClelland, PI, University of Washington Role: Subcontract Co-I, 5%

NIH-NIA 06/01/16-05/31/21 Transitions to Family Caregiving and its Impact on Health Indicators

Role: Subcontract PI NIH-NIMHD 08/14/18-03/31/22 R01 MD013349 The Add Health Epigenome Resource: Life course stressors and epigenomic modifications in adulthood K Harris, PI, University of North Carolina, Chapel Hill Role: Subcontract PI, 2.5% NIH-NIA 03/01/19-02/28/23 R01 AG061186 Use of High Density Lipoprotein Proteome in the Prediction of Cognitive Impairment and Alzheimer’s Disease: (REGARDS) RS Rosenson, R. Sidney, PI’s, Mount Sinai School of Medicine Role: Subcontract PI, 5% NIH-NHLBI 05/15/19-02/28/23 R01 HL141290 Thrombosis and Bleeding Risk Assessment in Medical Inpatients N Zakai, PI, University of Vermont Role: Co-Investigator, 5% NIH – NIGMS P20 GM135007 Vermont Center for Cardiovascular and Brain Health Center of Biomedical Research Excellence (COBRE) M Cushman, MPI, (25%) ADC: $1,560,000 (total $11,857,283) FUNDING: 8/6/2020-8/5/2025 NHLBI (C4R) RTI 22-312-0217571-66178 Collaborative Cohort of Cohorts for COVID-19 Research E Oelsner, PI, Columbia University M Cushman MPI subcontract 3% FUNDING: 10/01/20 – 9/13/22 ADC: $236,462 NIH - NIA U01 AG071450 The National Longitudinal Study of Adolescent Health Wave VIADRD A Aiello, PI, University of North Carolina, Chapel Hill M Cushman Co-PI subcontract 2% FUNDING: 01/15/21 – 12/31/25 ADC: $154,969

NIH – NIA U01 AG071448 The National Longitudinal Study of Adolescent Health Wave VI Core Project R Hummer, PI, University of North Carolina, Chapel Hill M Cushman PI subcontract 3% FUNDING: 04/01/21 – 03/31/26 ADC: $565,414

Kim Dittus VCC 55060 Dittus/Stein (Co-PI) 07/01/21-06/29/22

VDH Survivorship III – Vermont Department of Health Award Role: PI

Marc Greenblatt NIH-NHGRI Berg, Jonathan (PI) 09/01/13-08/31/21 U01 HG007437-01 A Knowledge Base for Clinically Relevant Genes and Variants Role: Co-Investigator

UVM Cancer Center Pilot Project Wood, Marie (PI) 01/2020 – 12//2021 Point of Care Testing for Patients with Advanced Cancer (PoC-TAC): A feasibility study Role: Co-Investigator U24 CA258119-01 Greenblatt, Marc (PI) 06/2021 – 05/2024 NCI InSiGHT-ClinGen Polyposis /Colon Cancer Variant Curation Expert Panel (VCEP) Role: PI

Chris Holmes NNE-CTR/NIGMS Holmes, Chris (PI) 06/2020 -05/2022 Improving VTE Risk Assessment: Education and Prophylaxis in Rural Cancer Clinics

Role: PI

NNECOS 01/15/20-04/30/21 VTE Risk Assessment and Prevention in Cancer Patients in the Community Oncology Setting S. Ades, PI/ Holmes-Co-I

5H30MC24048-04-00 Walsh (PI) 06/01/10-05/31/21

Department of Health and Human Services Human Resources and Services Administration Hemophilia Treatment Centers (SPRANS)

Role: Collaborating PI ATHN2011001-1-1 Croteau (PI) 09/30/11-09/29/21 Centers for Disease Control and Prevention American Thrombosis and Hemostasis Network

Public Health Surveillance for the Prevention of Complications of Bleeding and Clotting Disorders

Role: Co-Investigator NIH-NHLBI05/15/19-02/28/23 R01 HL141290 Thrombosis and Bleeding Risk Assessment in Medical Inpatients N Zakai, PI, University of Vermont Role: Co-Investigator

Peter Kaufman, MD Industry Sponsored Kaufman (International Co-Chair) 06/10/19-Ongoing

Clinical Research Grant Polyphor Pharma An International, Phase 3, Multicenter, Randomized, Open-Label Trial Comparing Balixafortide in combination with Eribulin versus Eribulin alone in Patients with HER2 negative, Locally Recurrent or Metastatic Breast Cancer (FORTRESS) 1P01CA240685-01A1 Stein (PI) 04/01/21-03/31/26 Epigenetic Control and Genome Organization $1,678.92 Role: Co-Investigator 5% FTE Lilly Pharmaceuticals Kaufman (PI) EMBER: A Phase 1a/1b Study of LY3484356 Administered as Monotherapy and in Combination with Anticancer Therapies for Patients with ER+ Locally Advanced or Metastatic Breast Cancer and Other Select Non-Breast Cancers Role: PI Sanofi Pharma Kaufman (PI) An open-lab randomized Phase 2 trial of SAR439859, versus endocrine monotherapy as per physician’s choice in patients with estrogen receptor-positive HER2-negative locally advanced or metastatic breast cancer with prior exposure to hormonal therapies Role: PI Sanofi Pharma Phase 2 window study of two dose levels of SAR439859 (SERD) versus letrozole in newly diagnosed preoperative post-menopausal patients with ER positive, HER2 negative primary breast cancer

Lilly Pharmaceuticals Kaufman (PI) monarchE: Protocol I3Y-MC-JPCF A Randomized, Open-Label, Phase 3 Study of Abemaciclib Combined with Standard Adjuvant Endocrine Therapy versus Standard Adjuvant Endocrine Therapy Alone in Patients with High Risk, Node Positive, Early Stage, Hormone Receptor Positive, Human Epidermal Receptor 2 Negative, Breast Cancer

Julian Sprague, MD

Graduate Medical Educator of the Year (2021), $6000 grant for a project

Eswar Tipirneni, MD

NNE-CTR/NIGMS Holmes (PI) 06/2020 Improving VTE Risk Assessment: Education and Prophylaxis in Rural Cancer Clinic Role: Site PI

Marie Wood Dana Farber Cancer Garber (PI) 09/15/19-09/14/23 Institute/Dept of Defense

BC181146: CDMRP Breast Cancer Research Program Breakthrough Award Prospectively Randomized, Placebo-Controlled Phase III Study to Determine the Effect of Denosumab on Breast Cancer Prevention in BRACA1 Mutation Carries Role: Subaward PI UVMCC Wood (PI) 08/14/18-07/31/25 Point of Care (POC) Testing for Patients with Advanced Cancer (PoC-TAC): A feasibility study Role: PI Alliance NCORP Bertagnolli (PI) 08/14/18-07/31/25 Research Base 5UGICA189823-03 Prevention Committee Co-Chair Role: Subaward PI NNECOS Wood (PI) 04/01/19-10/31/21 Attitudes, Beliefs and Practices Regarding Point of Care Genetic Testing among Northern New England Medical Oncologists Role: PI (mentor to Kevin Qin, MD PhD)

Neil Zakai NIH-NHLBI Zakai (PI) 05/15/19-02/28/23 R01 HL141290 Thrombosis and Bleeding Risk Assessment in Medical Inpatients Each year there are 10 million non-surgical admissions to hospitals in the United States, which are associated with 200,000 venous thromboembolism (VTE) events and an equal or greater number of bleeding events. Despite a lack of validated risk models, providers are required to assess VTE and bleeding risk on admission to the hospital, and provide VTE prophylaxis to those at low risk of bleeding and high risk of VTE. Our goals, in two complementary healthcare systems (located at the University of Vermont and the University of Washington), are to develop and validate robust models to assess hospital-acquired bleeding and VTE risk, and determine the period of increased risk for bleeding and VTE after discharge from the hospital Role: PI 30% CDC (6 NU38OT000280-03-02) Zakai (PI) 09/01/20 – 07/30/22 1.20 Calendar Months CDC $1,400,000 Understanding risk factors and burden of COVID-19 related thrombosis and bleeding complications High rates of thrombosis and bleeding have been reported in hospitalized COVID-19 patients leading to clinical uncertainty as to the benefit of anticoagulation. Pooling data from 9 hospital systems and over 10,000 hospitalized COVID-19 patients, we will determine the absolute and relative rates of thrombosis and bleeding in COVID-19 patients as well as the association of antithrombotic medications with outcomes. Further, it is not known what role health disparities may play in the development of COVID related thrombosis. Better understanding of thrombosis and treatment in COVID 19 patients is essential in developing clinical and public health programs that could reduce the risk or improve the outcome

U01 NS041588 Howard (PI) 02/15/18-01/31/23 NINDS

VCID and Stroke in a Bi-racial National Cohort This study plans to extend follow-up for incident stroke and cognitive decline in a national cohort of 30,000 black and white community dwelling participants. This proposal will identify mechanisms of racial and geographic disparities in dementia, and identify pathways and biomarkers for the development of hypertension and diabetes

Role: Subcontract—Co investigator 10% R01HL131579 Lutsey (PI) 01/01/17-11/30/20 NIH/NHLBI Contemporary Venous Thromboembolism Treatment

Recent introduction of novel oral anticoagulant drugs have transformed the management of venous thromboembolism (VTE), however we have little real-world experience with the side-effects of these medications. This grant uses data from two

large U.S. commercial claims databases (OptumInsight and MarketScan) to see whether real-life outcomes differ between traditional treatment of VTE and novel treatments and if bleeding and recurrent thrombosis differ

Role: Co-Investigator R01 HL132947 Reiner (PI) 04/01/17-03/31/21 NIH Thrombosis Genetics in African Americans

The primary objective of this project is to measure several emerging thrombosis and inflammation plasma biomarkers that are likely to reflect and/or account for increased thrombogenicity and therefore may contribute to higher rates of CVD in African Americans, and to assess the association of thrombosis biomarkers and biomarker-associated genetic variants with more complex subclinical and clinical CVD endpoints available in JHS and other African American cohorts, including REGARDS Role: Subcontract Investigator

RO1 HL136373 Pamir (PI) 01/15/18-12/31/22 NIH

Identification of the Role of HDL Function in Human Cardiovascular Disease through Proteomics and Genetics. The primary aims seek to assess whether high-density lipoprotein cholesterol efflux capacity and the protein composition of HDL provide predictive value of assessing the risk of coronary heart disease and stroke in Caucasian and African-Americans relative to HDL cholesterol and apolipoprotein A1 level

Role: Subcontract Investigator

NIH Kanaya (PI) 04/01/19-03/31/25 Tri-Asian Cohort on Cardiometabolic (TRACC) Health The general aim of this proposal is to provide fundamental clinical and biological data about cardiometabolic risk factor profiles including magnetic resonance imaging of the heart, great vessels, abdomen; to track changes in behavioral, psychological, sociocultural and contextual factors among Asian immigrants; and to investigate mechanisms that influence cardiometabolic risk aortic stiffness, hepatic and myocardial fibrosis Role: Subcontract PI

Publications

Lutsey PL, MacLehose RF, Claxton JS, Walker RF Adam TJ, Alonso A, Zakai NA. Impact of oral anticoagulation choice on healthcare utilization for primary treatment of venous thromboembolism. Vasc Med. 2020 Jul 27;1358863X20940388. doi: 10.1177/1358863X20940388. PMID: 32716254

Roth DL, Haley WE, Sheehan OC, Huang J, Rhodes JD, Durda P, Howard VJ, Walston JD, Cushman M. The transition to family caregiving and its effect on biomarkers of inflammation. Proc Natl Acad Sci U S A. 2020 Jul 14:117(28):16258-16263. doi: 10.1073/pnas/2000792117. PMID: 32581123 Bikdeli B, Madhaven MV, Gupta A, Jimenez D, Burton JR, Der Nigoghossian C, Chuich T, Nouri SN, Dreyfus I, Driggin E, Sethi S, Sehgal K, Chatterjee S, Ageno W, Madjid M, Guo Y Tang LV, Hu Y, Bertoletti L, Giri J, Cushman M, Quere I, Dimakakos EP, Gibson CM, Lippi G, Favaloro E, Fareed J, Tafur AJ, Francese DP, Batra J, Falanga A, Clerkin KJ, Uriel N, Kirtane A, McLintock C, Hunt BJ, Spyropoulos AC, Barnes GD, Eikelboom JW, Weinberg I, Schulman S, Carrier M, Piazza G, Beckman JA, Leon MB, Stone GW, Rosenkranz S, Goldhaber SZ, Parikh SA, Monreal M, Krumholz HM, Konstantinides SV, Weitz JI, H Lp GY, Global COVID-19 Thrombosis Collaborative Group. Pharmacological Agents Targeting Thromboinflammation in COVID-19: Review and Implications for Future Research. Thromb Haemost. 2020 Jul;120(7):1004-1024. doi: 10.1055/s-0040-1713152. PMID: 32473596 Cushman M, Barnes GD, Creager MA, Diaz JA, Henke PK, Machlus KR, Nieman MT, Wolberg AS, American Heart Association Council on Peripheral Vascular Disease, Council on Arteriosclerosis, Thrombosis, and Vascular Biology, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, Council on Epidemiology and Prevention, and International Society on Thrombosis and Haemostasis (ISTH). Venous thromboembolism research priorities: A scientific statement from the American Heart Association and the International Society on Thrombosis and Haemostasis. Res Pract Thromb Haemost. 2020 Jul 8;4(5):714-721. doi: 10.1002/rth2.12373. PMID: 32685877 Thachil J, Cushman M, Srivastava A. A proposal for staging COVID-19 coagulopathy. Res Pract Thromb Haemost. 2020 Jul 6;4(5):731-736. doi: 10.1002/rth2.12372. PMID: 32685880 Gilchrist SC, Howard VJ, Akinyemiju T, Judd SE, Cushman M, Hooker SP, Diaz KM. Association of Sedentary Behavior with Cancer Mortality in Middle-aged and Older US Adults. JAMA Oncol. 2020 Aug 1;6(8):1210-1217 18. doi: 10.1001/jamaoncol.2020.2045. PMID: 32556069

Karabachev AD, Martini DJ, Hermel DJ, Solcz D, Richardson ME, Pesaran T, Sarkar IN, Greenblatt MS. Curated multiple sequence alignment for the Adenomatous Polyposis Coli (APC) gene and accuracy of in silico pathogenicity predictions. PLoS One. 2020 Aug 4;15(8):e0233673. doi: 10.1371/journal.pone.0233673. PMID: 32750050

Cushman M, Barnes GD, Creager MA, Diaz JA, Henke PK, Machlus KR, Nieman MT, Wolberg AS, American Heart Association Council on Peripheral Vascular Disease; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology on Epidemiology and Prevention; and the International Society on Thrombsis and Haemostasis. Venous Thromboembolism

Research Priorities: A Scientific Statement From the American Heart Association and the International Society on Thrombosis and Haemostasis. Circulation. 2020 Aug 11;142(6):e85-e94. doi: 10.1161/CIR.0000000000000818. PMID: 32776842 Chamberlin MD, Wells JD, Shee K, Bean JR, Marotti JD, Wells WA, Trask HW, Kolling FW, Bhatt A, Kaufman PA, Schwartz GN, Gemery JM, McNulty NJ, Tsapakos MJ, Barth RJ, Arrick BA, Gui J, Miller TW. Plasma DNA as a “liquid biopsy” incompletely complements tumor biopsy for identification of mutations in a case series of four patients with oligometastatic breast cancer. Breast Cancer Res Treat. 2020 Aug;182(3):665-677. doi: 10.1007/s10549-020-05714-2. PMID: 32562118 Holmes CE, Ades S, Gilchrist S, Douce D, Libby K, Rogal B, Parenteau E, Cushman M; Kaigle Hom, A. Successful Model for Guideline Implementation to Prevent Cancer-Associated Thrombosis: Venous Thromboembolism Prevention in the Ambulatory Cancer Center. JCO Oncol Practice. 2020 Sept; 16(9):e868-e874. doi: 10.1200/JOP.19.00697. PMID: 32267798 Dominguez-Valentin M, Sampson JR, Seppälä TT, Ten Broeke SW, Plazzer JP, Nakken S, Engel C, Aretz S, Jenkins MA, Sunde L, Bernstein I, Capella G, Balaguer F, Thomas H, Evans DG, Burn J, Greenblatt M, Hovig E, de Vos Tot Nederveen Cappel WH, Sijmons RH, Bertario L, Tibiletti MG, Cavestro GM, Lindblom A, Della Valle A, Lopez-Köstner F, Gluck N, Katz LH, Heinimann K, Vaccaro CA, Büttner R, Görgens H, Holinski-Feder E, Morak M, Holzapfel S, Hüneburg R, Knebel Doeberitz MV, Loeffler M, Rahner N, Schackert HK, Steinke-Lange V, Schmiegel W, Vangala D, Pylvänäinen K, Renkonen-Sinisalo L, Hopper JL, Win AK, Haile RW, Lindor NM, Gallinger S, Le Marchand L, Newcomb PA, Figueiredo JC, Thibodeau SN, Wadt K, Therkildsen C, Okkels H, Ketabi Z, Moreira L, Sánchez A, Serra-Burriel M, Pineda M, Navarro M, Blanco I, Green K, Lalloo F, Crosbie EJ, Hill J, Denton OG, Frayling IM, Rødland EA, Vasen H, Mints M, Neffa F, Esperon P, Alvarez K, Kariv R, Rosner G, Pinero TA, Gonzalez ML, Kalfayan P, Tjandra D, Winship IM, Macrae F, Möslein G, Mecklin JP, Nielsen M, Møller P. Correction: Cancer risks by gene, age, and gender in 6350 carriers of pathogeni mismatch repair variants: findings from the Prospective Lynch Syndrome Database. Genet Med. 2020 Sep;22(9): 1569. doi: 10.1038/s41436-020-0892-4. PMID: 32690931 Suthahar N, Lau ES, Blaha MJ, Paniagua SM, Larson MG, Psaty BM, Benjamin EJ, Allison MA, Bartz TM, Januzzi JL Jr, Levy D, Meems LMG, Bakker SJL, Lima JAC, Cushman M, Lee DS, Wang TJ, deFilippi CR, Herrington DM, Nayor M, Vasan RS, Gardin JM, Kizer JR, Bertoni AG, Allen NB, Gansevoort RT, Shah SJ, Gottdiener JS, Ho JE, de Boer RA. Sex-specific associations of cardiovascular risk factors and biomarkers with incident heart failure. J Am Coll Cardiol 2020 Sep 22;76(12): 1455-1465. PMID: 32943164 Gergi M, Cushman M, Littenberg B, Budd RC. Thrombo-inflammation response to Tocilizumab in COVID-19. Res Pract Thromb Haemost 2020 Sep 25;4(8):1262-1268. doi: 10.1002/rth2.12436. PMID: 33043232

Uddin J, Malla G, Cherrington A, Zhu S, Cummings DM, Clay O, Brown TM, Lee L, Kimokoti R, Cushman M, Safford MM, Carson AP. Risk factor control among black and white adults with diabetes onset in older adulthood: the Reasons for Geographic and Racial Differences in Stroke Study. Prev Med. 2020 Oct;139:06217. doi: 10.1016/j.ypmed.2020.106217. PMID: 32702350 Ng H, Rogala BG, Ades S, Schwartz JR, Ashikaga T, Vacek P, Holmes CE Prospective Evaluation of drug-drug interactions in Ambulatory Cancer Patients Initiated on Prophylactic Anticoagulation J Oncol Pharm Practice; 2020 Oct;26(7):1637-1642. doi: 10.1177/1078155220901569. PMID: 32046579 Plante TB, Koh I, Judd SE, Howard G, Howard VJ, Zakai NA, Booth JN 3rd, Safford M, Muntner P, Cushman M. Life’s Simple 7 and incident hypertension: The REasons for Geographic and Racial Differences in Stroke (REGARDS) Study. J Am Heart Assoc. 2020 Oct 20;9(19):e016482. doi. 10.1161/JAHA.120.016482. PMID: 32928039 Darzi AJ, Repp AB, Spencer FA, Morsi RZ, Charide R, Etxeandia-Ikobaltzeta I, Bauer KA, Burnett AE, Cushman M, Dentali F, Kahn SR, Rezende SM, Zakai NA, Agarwal A, Karam SG, Lotfi T, Wiercioch W, Waziry R, Iorio A, Akl EA, Schünemann HJ. Risk assessment models for VTE and bleeding in hospitalized medical patients: an overview of systematic reviews. Blood Adv 2020 Oct 13;4(19):4929-4944. doi: 10.1182/bloodadvances.2020002482. PMID: 33049056 Teramoto K, Santos M, Claggett B, John JE, Solomon SD, Kitzman D, Folsom AR, Cushman M, Matsushita K, Skali H, Shah AM. Pulmonary vascular dysfunction among people aged over 65 years in the community in the Atherosclerosis Risk In Communities (ARIC) Study: A cross-sectional analysis. PloS Med 2020 Oct 15;17(10):e1003361. Doi: 10.1371/journal.pmed.1003361. PMID: 33057391 Lackland DT, Howard VJ, Cushman M, Oparil S, Kissela B, Safford MM, Kleindorfer DO, McClure LA, Howard G. Forty year shifting distribution of systolic blood pressure with population hypertension treatment and control. Circulation 2020 Oct 20;142(16):1524-1531. doi: 10.1161/CIRCULATIONAHA.120.048063. PMID: 33016101 Plubell DL, Fenton AM, Rosario S, Bergstrom P, Wilmarth PA, Clark WM, Zakai NA, Quinn JF, Minnier J, Alkayed NJ, Fazio S, Pamir N. High-Density Lipoprotein Carries Markers That Track With Recovery From Stroke. Circ Res. 2020 Oct 23;127(10): 1274-1287. doi: 10.1161/CIRCRESAHA.120.316526. PMID: 33313473

Khera R, Pandey A, Ayers CR, Carnethon MR, Greenland P, Ndumele CE, Nambi V, Seliger SL, Chaves PHM, Safford MM, Cushman M, Xanthakis V, Ramachandran VS, Mentz RJ, Correa A, Lloyd-Jones DM, Berry JD, de Lemos JA, Neeland IJ. Performance of the pooled cohort equations to estimate atherosclerotic cardiovascular disease risk by body mass

index. JAMA Netw Open 2020 Oct 1;3(10):e2023242. doi: 10.1001jamanetworkopen.2020.23242. PMID: 33119108 Pendlebury EC, Cushman M. Diversity, equity, and inclusion in publishing: Calling thrombosis and hemostasis journals to action in support of women. Res Pract Thromb Haemost 2020 Oct 16;4(7):1076-1079. doi: 10.1002/rth2.12434. PMID: 33134772 Al-Samkari H, Naik RP, Zakai NA. A hematologic support score for longitudinal measurement of blood and iron requirements in hereditary hemorrhagic telangiectasia and other chronic bleeding disorders. Res Pract Thromb Haemost. 2020 Oct 28;4: 1340-1342. doi: 10.1002/rth2.12444. PMID: 33313473 Kamin Mukaz D, Zakai NA, Cruz-Flores S, McCullough LD, Cushman M. Identifying genetic and biological determinants of race-ethnic disparities in stroke in the United States. Stroke 2020 Nov;51(11):3417-3424. doi: 10.1161/STROKEAHA.120.030425. PMID: 33104469

Evans, CR, Hong, CP, Folsom, AR, Heckbert, SR, Smith, NL, Wiggins, KL, Lutsey PL, Cushman, M. Lifestyle moderates genetic risk of venous thromboembolism: the Atherosclerotic Risk in Communities study. Arterioscler Thromb Vasc Biol 2020 Nov;40(11):2756-2763. doi: 10.1161/ATVBAHA.120.314668. PMID: 32878478 Rohmann JL, Longstreth WT Jr, Cushman M, Fitzpatrick AL, Heckbert SR, Rice K, Rosendaal FR, Sitlani CM, Psaty BM, Siegerink B. Coagulation factor VIII, white matter hyperintensities and cognitive function: results from the Cardiovascular Health Study. PLoS One 2020 Nov; 16;15(11):e0242062. doi: 10.1371/journal.pone.0242062. PMID: 33196677 Kazmi S, Chatterjee D, Raju D, Hauser R, Kaufman PA. Overall survival analysis in patients with metastatic breast cancer and liver or lung metastases treated with eribulin, gemcitabine, or capecitabine. Breast Cancer Res Treat. 2020 Nov;184(2):559-565. doi: 10.1007/s10549-020-05867. PMID: 32808239

Arce Rentería M, Gillett SR, McClure LA, Wadley VG, Glasser SP, Howard VJ, Kissela BM, Unverzagt FW, Jenny NS, Manly JJ, Cushman M. C-reactive protein and risk of cognitive decline: the REGARDS study. PLoS One 2020 Dec 31;15(12):e0244612. doi: 10.1371/journal.pone.0244612. PMID: 33382815 French SA, Lutsey PL, Rosamond W, MacLehose RF, Cushman M, Folsom AR. Weight change over 9 years and subsequent risk of venous thromboembolism in the ARIC cohort. in press, Int J Obes (Lond). 2020 Dec;44(12):2465-2471. doi: 10.1038/s41366-020-00674-5. PMID: 32948842

Lutsey PL, MacLehose RF, Claxton JS, Walker RF, Adam TJ, Alonso A, Zakai NA. Impact of oral anticoagulation choice on healthcare utilization for the primary treatment of venous thromboembolism. Vasc Med. 2020 Dec;25(6): 549-556. doi: 10.1177/1358863X20940388. PMID: 32716254 Gergi M, Landry KK, Ades S, Barry M, Zakai NA, Herrera DA. Nivolumab-Induced Thrombotic Thrombocytopenic Purpura in a Patient with Anal Squamous Cell Carcinoma: A Lesson on Hematologic Toxicity from Immunotherapy. Oncologist. 2020 Dec; 25(12):1009-1012. doi: 10.1002/onco.13553. PMID: 33017484 Folsom AR and Cushman M. Exploring opportunities for primary prevention of unprovoked venous thromboembolism: ready for prime time? J Am Heart Assoc 2020 Dec;9(23):e019395. doi: 10.1161/JAHA.120.019395. PMID: 331191841

Plante TB, Long DL, Guo B, Howard G, Carson AP, Howard VJ, Judd SE, Jenny NS, Zakai NA, Cushman M. C-reactive protein and hypertension incidence in black and white Americans: REasons for Geographic And Racial Differences in Stroke (REGARDS) study. Am J Hypertens. 2020 Dec 16;hpaa215. Doi: 10.1093/ajh/hpaa215. PMID: 33326556

Hyacinth HI, Franceschini N, Seals SR, Irvin MR, Chaudhary N, Naik RP, Alonso A, Carty CL, Burke GL, Zakai NA, Winkler CA, David VA, Kopp JB, Judd SE, Adams RJ, Gee BE, Longstreth WT Jr, Egede L, Lackland DT, Greenberg CS, Taylor H, Manson JE, Key NS, Derebail VK, Kshirsagar AV, Folsom AR, Konety SH, Howard V, Allison M, Wilson JG, Correa A, Zhi D, Arnett DK, Howard G, Reiner AP, Cushman M, Safford MM. Incidence of coronary heart disease among African Americans with sickle cell trait: A meta-analysis. JAMA Netw Open. 2021 Jan 4;4(1):e2030435. doi: 10.1001jamanetworkopen.2020.30435. PMID: 33399855 Wang H, Cushman M, Rosendaal FR, van Hylckama Vlieg A. Procoagulant factor levels and risk of venous thrombosis in the elderly. J Thromb Haemost 2021 Jan;19(1):186-193. doi: 10.1111/jth.15127. PMID: 33090602

Nicoli CD, Wettersten N, Judd SE, Howard G, Howard VJ, Struck J, Cushman M. Pro-neurotensin/neuromedin N and risk of ischemic stroke: The REasons for Geographic And Racial Differences in Stroke (REGARDS) study. Vasc Med 2020 Dec;25(6):534-540. doi: 10.1177/1358863X20957406. PMID: 33089749

Lester-Coll NH, Ades S, Yu JB, Atherly A, Wallace HJ, Sprague BL. Cost-effectiveness of Prostate Radiation Therapy for Men with Newly Diagnosed Low-Burden Metastatic Prostate Cancer. JAMA Netw Open. 2021 Jan 4;4(1):e2033787. doi: 10.1001/jamanetworkopen.2020.33787. PMID: 33439266

Adrianzen-Herrera D, Jordan-Bruno X, Devitt KA, Conant JL, Gardner JA. Acquired BCR-ABL1 fusion and IDH1 Clonal evolution following BCL2 inhibitor treatment in refractory

acute myeloid leukemia. Leuk Res. 2021 Jan;100:106494. doi: 10.1016/j.leukres.2020.106494. PMID: 33387682

Jaffray J, Branchford B, Goldenberg N, Malvar J, Croteau SE, Silvey M, Fargo JH, Cooper JD, Bakeer N, Sposto R, Ji L, Zakai NA, Faustino EV, Stillings A, Krava E, Young G. Development of a Risk Model for Pediatric Hospital-Acquired Thrombosis: A Report from the Children’s Hospital-Acquired Thrombosis Consortium. J Pediatr. 2021 Jan;228:252-259.e1. doi: 10.1016/j.jpeds.2020.09.016. PMID: 32920105

Martens KL, da Costa WL, Amos CI, Davis C, Kesten M, Lee SJ, Zakai NA, Garcia DA, Li A. HIGH-2-LOW risk model to predict venous thromboembolism in allogeneic transplant patients after platelet engraftment. Blood Adv. 2021 Jan 12;5(1):167-175. doi: 10.1182/bloodadvances.2020003353. PMID: 33570631

Jasra S, Kazemi M, Shah N, Chen J, Fehn K, Wang Y, Mantzaris I, Kornblum N, Sica A, Bachier LM, Goldfinger M, Gritsman K, Braunschweig I, Steidl U, Shastri A, Verma A. Case report of combination therapy with Azacytidine, Enasidenib and Venetoclax in primary refractory AML. Exp Hematol Oncol. 2021 Jan 4;10(1):1.doi: 10.1186/s40164-020-00186-y. PMID: 33397455

Cornell R, Hari P, Tang S Biran N, Callander N, Chari A, Chhabra S, Fiala MA, Gahvari Z, Gandhi U, Godby K, Gupta R, Jagannath S, Jagosky M, Kang Y, Kansagra A, Kauffman M, Kodali S, Kumar SK, Lakshman A, Liedtke M, Lonial S, Ma X, Malek E, Mansour J, McGehee EF, Neppalli A, Paul B, Richardson P, Scott EC, Shacham S, Shah J, Siegel DS, Umyarova E, Usmani S, Varnado W, Vij R, Costa L. Overall survival of patients with triple-class refractory multiple myeloma treated with selinexor plus dexamethasone vs standard of care in MAMMOTH. Am J Hematol. 2021 Jan;96;(1):E5-E8. doi: 10.1002/ajh.26010. PMID: 32974944 Dominguez-Valentin M, Sampson JR, Møller P, Seppälä TT; PLSD Collaborators. Analysis in the Prospective Lynch Syndrome Database identifies sarcoma as part of the Lynch syndrome tumor spectrum. Int J Cancer. 2021 Jan 15;148(2):512-513. doi: 10.1002/ijc.33214. PMID: 32783184

Reiner AP, Raffield LM, Franceschini N, Auer PL, Lange EM, Nickerson DA, Zakai NA, Correa A, Olson N, National Heart Lung, and Blood Institute Trans-Omics for Precision Medicine Consortium; Natinal Heart Lung, and Blood Institute Trans-Omics for Precision Medicine Consortium. Effect of Sickle Cell Trait and APOL1 Genotype on the Association of Soluble uPAR with Kidney Function Measures in Black Americans. Clin J Am Soc Nephrol. 2021 Feb 8;16(2):287-289. doi: 10.2215/CJN.12100720. PMID: 33268503

Couch CA, Gray MS, Shikany JM, Howard VJ, Howard G, Long DL, McClure LA, Manly JJ, Cushman M, Zakai NA, Pearson KE, Levitan EB, Judd SE. Correlates of a southern diet pattern in a national cohort study of blacks and whites: the Reasons for Geographic And

Racial Differences in Stroke (REGARDS) study. Br J Nutr. 2021 Feb 26;1-7. doi: 10.1017/S00007114521000696. PMID: 33632366

Valderrabano RJ, Buzkova P, Chang P-Y, Zakai NA, Fink HA, Robbins JA, Wu JY, Lee JS, Cardiovascular Health Study group. Associations of hemoglobin and change in hemoglobin with risk of incident hip fracture in older men and women: the cardiovascular health study. Osteoporos Int. 2021 Feb 12. doi: 10.1007/s00198-021-05873-y. PMID: 33576845

Wood M, George TJ, Manochakian R, Polansky M, Baer A, Grupe A, Shyr Y, Wang C, Horn L. Quantitative Assessment of Learning Behaviors for Oncology Providers. J Cancer Educ. 2021 Feb;36(1):25-32. doi: 10.1007/s13187-019-01593-4. PMID: 31377987

Ahern TP Sprague BL, Farina NH, Tsai E, Cuke M, Kontos D, Wood ME. Lifestyle, Behavioral, and Dietary Risk Factors in Relation to Mammographic Breast Density in Women at High Risk for Breast Cancer. Cancer Epidemiol Biomarkers Prev. 2021 Feb 22. doi: 10.1158/1055-9965.EPI-20-1567. PMID: 33619019

Kaufman PA, Hurvitz SA, O’Shaughnessy J, Mason G, Yardley DA, Brufsky AM, Rugo HS, Cobleigh M, swain SM, Tripathy D, Morris A, Antao V, Li H, Jahanzeb M. Baseline characteristics and first-line treatment patters in patients with HER2-positive metastatic breast cancer in the SystHERs registry. Breast Cancer Res Treat. 2021 Feb 28. doi: 10.1007/s10549-021-06103-z. PMID: 33641083

Yi SY, Steffen LM, Lutsey PL, Cushman M, Folsom AR. Contrasting Associations of Prudent and Western Dietary Patterns with Risk of Developing Venous Thromboembolism. Am J Med. 2021 Feb 17;S0002-9343(21)00095-4. doi: 10.1016/j.amjmed.2021.01.016. PMID: 33609530

Huayanay-Espinoza IE, Guerra-Castanon F, Reyes-Diaz M, Lazo-Porras M, de la Cruz-Luque C, Adrianzen Herrera D, Malaga G. Quality of life and self-efficacy in patients with type 2 diabetes mellitus in a Peruvian public hospital. Medwave. 2021 Mar 22;21(2):e8133. doi: 10.5867/medwave.2021.02.8132. PMID: 33830978

Ong KL, McClelland RL, Allison MA, Cushman M, Garg PK, Tsai MY, Rye KA, Tabet F. Lipoprotein (a) and coronary artery calcification: prospective study assessing interactions with other risk factors. Metabolism. 2021 Mar;116:154706. doi: 10.1016/j.metabol.2021.154706. PMID: 33421505 Liu C, Roth DL, Gottesman RF, Sheehan OC, Blinka MD, Howard VJ, Judd SE, Cushman M. Change in Life's Simple 7 measure of cardiovascular health after incident stroke: the REGARDS study. Stroke 2021 Mar;52(3):878-886. doi: 10.1161/STROKEAHA.120.030836. PMID: 33467879

Poston JN, Jash A, Hannan LM, Hay AM, Usaneerungrueng C, Howie HL, Kapp LM, Zimring JC. In utero exposure to alloantigens primes alloimmunization to platelet transfusion in mice. Transfusion. 2021 Mar;61(3):687-691. doi: 10.1111/trf.16224. Epub 2020 Dec 18. PMID: 33336414. Scholzberg M, Tang GH, Negri E, Rahhal H, Kreuziger LB, Pompilio CE, James P, Fralick M, AlHamzah M, Alomran F, Tseng E, Lim G, Lillicrap D, Carrier M, Áinle FN, Beckett A, da Costa BR, Thorpe K, Middeldorp S, Lee A, Cushman M, Jüni P. Coagulopathy of hospitalised COVID-19: A Pragmatic Randomised Controlled Trial of Therapeutic Anticoagulation versus Standard Care as a Rapid Response to the COVID-19 Pandemic (RAPID COVID COAG – RAPID Trial): A structured summary of a study protocol for a randomised controlled trial. Trials. 2021 Mar 10;22(1):202. doi: 10.1186/s13063-021-05076-0. PMID: 33691765

Oelsner EC, Allen NB, Ali T, Anugu P, Andrews H, Asaro A, Balte PP, Barr RG, Bertoni AG, Bon J, Boyle R, Chang AA, Chen G, Cole SA, Coresh J, Cornell E, Correa A, Couper D, Cushman M, Demmer RT, Elkind MSV, Folsom AR, Fretts AM, Gabriel KP, Gallo L, Gutierrez J, Han MK, Henderson JM, Howard VJ, Isasi CR, Jacobs DR, Judd SE, Mukaz DK, Kanaya AM, Kandula NR, Kaplan R, Krishnaswamy A, Kinney GL, Kucharska-Newton A, Lee JS, Lewis CE, Levine DA, Levitan EB, Levy B, Make B, Malloy K, Manly JJ, Meyer KA, Min YI, Moll M, Moore WC, Mauger D, Ortega VE, Palta P, Parker MM, Phipatanakul W, Post W, Psaty BM, Regan EA, Ring K, Roger VL, Rotter JI, Rundek T, Sacco RL, Schembri M, Schwartz DA, Seshadri S, Shikany JM, Sims M, Hinckley Stukovsky KD, Talavera GA, Tracy RP, Umans JG, Vasan RS, Watson K, Wenzel SE, Winters K, Woodruff PG, Xanthakis V, Zhang Y, Zhang Y; C4R Investigators. Collaborative Cohort of Cohorts for COVID-19 Research (C4R) Study: Study Design. [preprint] medRxiv 2021 Mar 20;2021.03.19.21253986. doi: 10.1101/2021.03.19.21253986. PMID: 33758891

Navi BB, Kasner SE, Elkind MSV, Cushman M, Bang OY, DeAngelis LM. Cancer and Embolic Stroke of Undetermined Source. Stroke 2021 Mar;52(3):1121-1130. doi: 10.1161/STROKEAHA.120.032002. PMID: 33504187

Chen C, Xun P, Unverzagt F, McClure LA, Irvin MR, Judd S, Cushman M, He K. Serum magnesium concentration and incident cognitive impairment: the Reasons for Geographic and Racial Differences in Stroke study. In Press, Eur J Nutr. 2021 Apr;60(3):1511-1520. doi: 10.1007/s00394-020-02353-7. PMID: 32737612

Oni E, Ogunmoroti O, Allen N, A-Mallah MH, Blankstein R, Martin SS, Zeb I, Cushman M, Joshi PH, Budoff MJ, Blaha MJ, Blumenthal RS, Veledar E, Nasir K. Life’s Simple 7 and Non-Alcoholic Fatty Liver Disease: The Multi-Ethnic Study of Atherosclerosis. Am J Med. 2021 Apr;134(4):519-525. doi: 10.1016/j.amjmed.2020.09.023. PMID: 33285128

Talasaz AH, Sadeghipour P, Kakavand H, Aghakouchakzadeh M, Kordzadeh-Kermani E, Van Tassell BW, Gheymati A, Ariannejad H, Hosseini SH, Jamalkhani S, Sholzberg M, Monreal M, Jimenez D, Piazza G, Parikh SA, Kirtane AJ, Eikelboom JW, Connors JM, Hunt

BJ, Konstantinides SV, Cushman M, Weitz JI, Stone GW, Krumholz HM, Lip GYH, Goldhaber SZ, Bikdeli B. Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19: JACC State-of-the-Art Review. J Am Coll Cardiol. 2021 Apr;77(15):1903-1921. doi: 10.1016/j.jacc.2021.02.035. PMID: 33741176 Graff M, Justice AE, Young KL, …. Cushman M, Zakai NA….. Loos R, Ng MCY, North KE. Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry. Am J Hum Genet 2021 Apr 1;108(4):564-582. doi: 10.1016/j.ajhg.2021.02.011. PMID: 33713608

Carson AP, Long DL, Cherrington AL, Dutton GR, Howard VJ, Brown TM, Howard G, Safford MM, Cushman M. Sex differences in factors contributing to the racial disparity in diabetes risk. Am J Prev Med. 2021 Apr;60(4):e169-e177. doi: 10.1016/j.amepre.2020.09.016. PMID: 33279367

Dibaba DT, Cheng C, Liping L, Bidulescu A, Fly AD, Xun P, Judd SE, Cushman M, He K. Magnesium intake is inversely associated with risk of metabolic syndrome in the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort study. Clin Nutr. 2021 Apr;40(4):2337-2342. doi: 10.1016/j.clnu.2020.10.024. PMID: 33129598

Thibord F, Song, Pattee J, Rodriguez B, Chen MH, O’Donnell CJ, Kleber ME, Delgado GE, Guo X, Yao J, Taylor KD, Ozel AB, Brody JA, McKnight B, Gyorgy B, Simonsik E, Leonard HL, Carrasquilla GD, Guindo-Martinez M, Silveira A, Temprano-Sagrera G, Yanek LR, Becker DM, Mathias RA, Becker LC, Raffield LM, Kilpelainen TO, Grarup N, Pedersen O, Hansen T, Linneberg A, Hamsten A, Watkins H, Sabater-Lleal M, Nalls MA, Tregouet DA, Morange PE, Psaty BM, Tracy RP, Smith NL, Desch KC, Cushman M, Rotter JI, de Vries PS, Pankratz ND, Folsom AR, Morrison AC, Marz W, Tang W, Johnson AD. FGL1 as a modulator of plasma D-dimer levels: Exome-wide marker analysis of plasma tPA, PAI-1, and D-dimer. J Thromb Haemost. 2021 Apr 20. doi: 10.1111/jth.15345. PMID: 33876560

Harrington L, Ehlert AN, Thacker EL, Jenny NS, Lopez O, Cushman M, Fitzpatrick A, Mukamal KJ, Jensen MK. Hemostatic factor levels and cognitive decline in older adults: the Cardiovascular Health Study. J Thromb Haemost. 2021 May; 19(5):1219-1227. doi: 10.1111/jth.15300. PMID: 33725412

Wood ME, Liu H, Storrick E, Zahrieh D, Le-Petross HC, Jung SH, Zekan P, Kemeny MM, Charlamb JR, Wang LX, Unzeitig GW, Johnson CS, Garber JE, Marshall JR, Bedrosian I. The influence of vitamin D on mammographic density: results from CALGB 70806 (Alliance) a randomized clinical trial. Cancer Prev Res (Phila). 2021 Apr 13;canprevres.0581.2020. doi: 10.1158/1940-6207.CAPR-20-0581. PMID: 33849913 Dominguez-Valentin M, Crosbie EJ, Engel C, Aretz S, Macrae F, Winship I, Capella G, Thomas H, Nakken S, Hovig E, Nielsen M, Sijmons RH, Bertario L, Bonanni B, Tibiletti MG, Cavestro GM, Mints M, Gluck N, Katz L, Heinimann K, Vaccaro CA, Green K, Lalloo F, Hill J, Schmiegel W, Vangala D, Perne C, Strauß HG, Tecklenburg J, Holinski-Feder E, Steinke-

Lange V, Mecklin JP, Plazzer JP, Pineda M, Navarro M, Vidal JB, Kariv R, Rosner G, Piñero TA, Gonzalez ML, Kalfayan P, Ryan N, Ten Broeke SW, Jenkins MA, Sunde L, Bernstein I, Burn J, Greenblatt M, de Vos Tot Nederveen Cappel WH, Della Valle A, Lopez-Koestner F, Alvarez K, Büttner R, Görgens H, Morak M, Holzapfel S, Hüneburg R, von Knebel Doeberitz M, Loeffler M, Rahner N, Weitz J, Pylvänäinen K, Renkonen-Sinisalo L, Lepistö A, Auranen A, Hopper JL, Win AK, Haile RW, Lindor NM, Gallinger S, Le Marchand L, Newcomb PA, Figueiredo JC, Thibodeau SN, Therkildsen C, Okkels H, Ketabi Z, Denton OG, Rødland EA, Vasen H, Neffa F, Esperon P, Tjandra D, Möslein G, Sampson JR, Evans DG, Seppälä TT, Møller P. Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report. Genet Med. 2021 Apr;23(4):705-712. doi: 10.1038/s41436-020-01029. PMID: 33257847

Hu Y, Stilp AM, McHugh CP, Rao S, Jai D, Zheng X, Lane J, Méric de Bellefon S, Raffield LM, Chen MH, Yanek LR, Wheeler M, Yao Y, Ren C, Broome J, Moon JY, de Vries PS, Hobbs BD, Sun Q, Surendran P, Brody JA, Blackwell TW, Choquet H, Ryan K, Duggirala R, Heard-Costa N, Wang Z, Chami N, Preuss MH, Min N, Ekunwe L, Lange LA, Cushman M, Faraday N, Curran JE, Almasy L, Kundu K, Smith AV, Gabriel S, Rotter JI, Fornage M, Lloyd-Jones DM, Vasan RS, Smith NL, North KE, Boerwinkle E, Becker LC, Lewis JP, Abecasis GR, Hou L, O'Connell JR, Morrison AC, Beaty TH, Kaplan R, Correa A, Blangero J, Jorgenson E, Psaty BM, Kooperberg C, Walton RT, Kleinstiver BP, Tang H, Loos RJF, Soranzo N, Butterworth AS, Nickerson D, Rich SS, Mitchell BD, Johnson AD, Auer PL, Li Y, Mathias RA, Lettre G, Pankratz N, Laurie CC, Laurie CA, Bauer DE, Conomos MP, Reiner AP; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium. Whole genome sequencing association analysis of quantitative red blood cell phenotypes: the NHLBI TOPMed program. Am J Hum Genet.2021 May 6;108(5):874-893. doi: 10.1016/j.ajhg.2021.04.003. PMID: 33887194

Nicoli CD, Carson AP, Plante TB, Long DL, McClure LA, Schulte J, Cushman M. Pro-Neurotensin/Neuromedin N and Risk of Incident Metabolic Syndrome and Diabetes Mellitus in the REGARDS Cohort. J Clin Endocrinol Metab. 2021 May 20;dgab355. doi: 10.1210/clinem/dgab355. PMID: 34013344

Omran SS, Hartman A, Zakai NA, Navi BB. Thrombophilia Testing After Ischemic Stroke: Why, When, and What? Stroke. 2021 May;52(5):1874-1884. doi: 10.1161/STROKEAHA.120.032360. PMID: 33874743

MacLehose RF, Zakai NA, Walker RF, Alonso A, Adams T, Lutsey PL. Impact of oral anticoagulant choice for the secondary prevention of venous thromboembolism on the risk of inpatient bleeding. Res Pract Thromb Haemost. 2021 May 4;5(4):e12514. doi: 10.1002/rth2.12514. PMID: 33977213

Nicoli CD, Plante TB, Long DL, Judd SE, McClure LA, Arora P, Cushman M. N-Terminal Pro-B Type Natriuretic Peptide and Longitudinal Risk of Hypertension. Am J Hypertens. 2021 May 22;34(5):476-483. doi: 10.1093/ajh/hpaa224. PMID: 33378421

Short SA, Gupta S, Brenner SK, Hayek SS, Srivastava A, Shaefi S, Singh H, Wu B, Bagchi A, Al-Samkari H, Dy R, Wilkinson K, Zakai NA, Leaf DE, STOP-COVID Investigators d-dimer and Death in Critically Ill Patients With Coronavirus Disease 2019. Crit Care Med. 2021 May 1;49(5):e500-e511. doi: 10.1097/CCM.0000000000004917. PMID: 33591017

Ahern TP, Sprague BL, Farina NH, Tsai E, Cuke M, Kontos D, Wood ME. Lifestyle, Behavioral, and Dietary Risk Factors in Relation to Mammographic Breast Density in Women at High Risk for Breast Cancer. Cancer Epidemiol Biomarkers Prev. 2021 May;30(5):936-944. doi: 10.1158/1055-9965.EPI-20-1567. PMID: 33619019

Wiercioch W, Nieuwlaat R, Dahm P, Iorio A, Mustafa RA, Neumann I, Rochwerg B, Manja V, Alonso-Coello P, Ortel TL, Santesso N, Vesely SK, Akl EA, Schunemann HJ, Bates SM, Cuker A, Lim W, Monagle P, Kunkle R, Witt DM, Kahn SR, McLintock C, Rezende SM, Zakai NA, ASH VTE Panels Working Group. Development and application of health outcome descriptors facilitated decision-making in the production of practice guidelines. J Clin Epidemiol. 2021 May 13;S0895-4356(21)00139-6. doi: 10.1016/j.jclinepi.2021.04.016 PMID: 33992716 Seppälä TT, Dominguez-Valentin M, Crosbie EJ, Engel C, Aretz S, Macrae F, Winship I, Capella G, Thomas H, Hovig E, Nielsen M, Sijmons RH, Bertario L, Bonanni B, Tibiletti MG, Cavestro GM, Mints M, Gluck N, Katz L, Heinimann K, Vaccaro CA, Green K, Lalloo F, Hill J, Schmiegel W, Vangala D, Perne C, Strauß HG, Tecklenburg J, Holinski-Feder E, Steinke-Lange V, Mecklin JP, Plazzer JP, Pineda M, Navarro M, Vida JB, Kariv R, Rosner G, Piñero TA, Pavicic W, Kalfayan P, Ten Broeke SW, Jenkins MA, Sunde L, Bernstein I, Burn J, Greenblatt M, de Vos Tot Nederveen Cappel WH, Della Valle A, Lopez-Koestner F, Alvarez K, Büttner R, Görgens H, Morak M, Holzapfel S, Hüneburg R, von Knebel Doeberitz M, Loeffler M, Redler S, Weitz J, Pylvänäinen K, Renkonen-Sinisalo L, Lepistö A, Hopper JL, Win AK, Lindor NM, Gallinger S, Le Marchand L, Newcomb PA, Figueiredo JC, Thibodeau SN, Therkildsen C, Wadt KAW, Mourits MJE, Ketabi Z, Denton OG, Rødland EA, Vasen H, Neffa F, Esperon P, Tjandra D, Möslein G, Rokkones E, Sampson JR, Evans DG, Møller P. Uptake of hysterectomy and bilateral salpingo-oophorectomy in carries of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report. Eur J Cancer. 2021 May;148:124-133. doi: 10.1016/j.ejca.2021.02.022. PMID: 33743481

Munger JA, Koh I, Howard G, Howard V, Plante TB, Wilkinson K, Cushman M, Zakai N. Television viewing, physical activity and venous thromboembolism risk: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study. J Thromb Haemost. 2021 Jun 2. doi: 10.1111/jth.15408. PMID: 34077616

Yi SY, Steffen LM, Lutsey PL, Cushman M, Folsom AR. Contrasting Associations of Prudent and Western Dietary Patterns with Risk of Developing Venous Thromboembolism. Am J Med. 2021 Jun;134(6):763-768.e3. doi: 10.1016/j.amjmed.2021.01.016. PMID: 33609530

Stanislawski MA, Lange LA, Raffield LM, Zakai NA, Meyer M, Ferrier K, Szeto MD, Leavitt C, Shortt JA, Thornton TA, Tracy RP, Auer PL, Reiner AP, Lange EM, Olson NC. Soluble CD14 Levels in the Jackson Heart Study: Associations with Cardiovascular Disease Risk and Genetic Variants. Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):e378. doi:10.1161/ATVBAHA.121.316035. PMID: 33910371

Tolaney SM, Kalinsky K, Kaklamani VG, D’Adamo DR, Aktan G, Tsai ML, O’Regan RM, Kaufman PA, Wilks ST, Andreopoulou E, Patt DA, Yuan Y, Wang G, Savulsky C, Xing D, Kleynerman E, Karantza V, Diab S. Eribulin Plus Pembrolizumab in Patients with Metastatic Triple-Negative Breast Cancer (ENHANCE 1): A Phaste Ib/II Study. Clin Cancer Res. 2021 Jun 1;27(11):3061-3068. doi: 10.1158/1078-0432.CCR-20-4726. PMID: 33727258

Hu Y, Stilp AM, McHugh CP, Rao S, Jain D, Zheng X, Lane J, de Bellefon SM, Raffield LM, Chen MH, Yanek LR, Wheeler M, Yao Y, Ren C, Broome J, Moon JY, de Vries PS, Hobbs BD, Sun Q, Surendran P, Brody JA, Blackwell TW, Choquet H, Ryan K, Duggirala R, Heard-Costa N, Wang Z, Chami N, Preuss MH, Min N, Ekunwe L, Lange LA, Cushman M, Faraday N, Curran JE, Almasy L, Kundu K, Smith AV, Gabriel S, Rotter JI, Fornage M, Lloyd-Jones DM, Vasan RS, Smith NL, North KE, Boerwinkle E, Becker LC, Lewis JP, Abecasis GR, Hou L, O’Connell JR, Morrison AC, Beaty TH, Kaplan R, Correa A, Blangero J, Jorgenson E, Psaty BM, Kooperberg C, Walton RT, Kleinstiver BP, Tang H, Loos R, Soranzo N, Butterowrht AS, Nickerson D, Rich SS, Mitchell BD, Johnson AD, Auer PL, Li Y, Mathias RA, Lettre G, Pankratz N, Laurie CC, Laurie, CA, Bauer DE, Conomos MP, Reiner AP, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium. Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program. Am J Hum Genet. 2021 Jun 3;108(6):1165. doi: 10.1016/j.ajhg.2021.04.015. PMID: 34087167 Dominguez-Valentin M, Plazzer JP, Sampson JR, Engel C, Aretz S, Jenkins MA, Sunde L, Bernstein I, Capella G, Balaguer F, Macrae F, Winship IM, Thomas H, Evans DG, Burn J, Greenblatt M, de Vos Tot Nederveen Cappel WH, Sijmons RH, Nielsen M, Bertario L, Bonanni B, Tibiletti MG, Cavestro GM, Lindblom A, Valle AD, Lopez-Kostner F, Alvarez K, Gluck N, Katz L, Heinimann K, Vaccaro CA, Nakken S, Hovig E, Green K, Lalloo F, Hill J, Vasen HFA, Perne C, Büttner R, Görgens H, Holinski-Feder E, Morak M, Holzapfel S, Hüneburg R, von Knebel Doeberitz M, Loeffler M, Rahner N, Weitz J, Steinke-Lange V, Schmiegel W, Vangala D, Crosbie EJ, Pineda M, Navarro M, Brunet J, Moreira L, Sánchez A, Serra-Burriel M, Mints M, Kariv R, Rosner G, Piñero TA, Pavicic WH, Kalfayan P, Broeke SWT, Mecklin JP, Pylvänäinen K, Renkonen-Sinisalo L, Lepistö A, Peltomäki P, Hopper JL, Win AK, Buchanan DD, Lindor NM, Gallinger S, Marchand LL, Newcomb PA, Figueiredo JC, Thibodeau SN, Therkildsen C, Hansen TVO, Lindberg L, Rødland EA, Neffa F, Esperon P, Tjandra D, Möslein G, Seppälä TT, Møller P. No Difference in Penetrance between Truncating and Missense/Aberrant Splicing Pathogenic Variants in MLH1 and MSH2: A Prospective Lynch Syndrome Database Study. J Clin Med. 2021 Jun 28;10(13):2856. doi: 10.3390/jcm10132856. PMID: 34203177

Division of Hospital Medicine: Update for July 1, 2020 - June 30, 2021 Chief: Caroline Lyon MD, MPH, FSHM

The Division of Hospital Medicine at the Larner College of Medicine at the University of Vermont pursues excellence in academic Hospital Medicine by:

• Delivering compassionate, responsive, integrated care to medical inpatients 24 hours a day

• Teaching the science, art, and joy of medicine to students, trainees, and colleagues

• Promoting knowledge through research and educational efforts • Cultivating a collegial and sustainable practice environment • Collaborating with members of the hospital and university community to

improve the quality, safety and value of inpatient care Our Hospitalist faculty physicians are involved in all aspects of the academic teaching hospital mission, including providing valuable clinical services, teaching a broad range of learners, engaging in leadership and system improvement while advancing a broad research agenda. Service: The Adult Hospital Medicine Service (AHMS) specializes in the diagnosis and treatment of hospitalized adults, both as the primary service and in the role of consultant – with our service providing 24x7 attending coverage. We serve as physician leadership for the Rapid Response Team, which responds to inpatients with medical emergencies throughout the hospital. Our Hospitalists work in multi-disciplinary teams to provide effective, safe, timely and patient-centered care. We also offer medical consultation to patients in the inpatient acute rehabilitation program. The AHMS includes four General Internal Medicine teaching services (each with an attending, three residents, and 3rd and 4th year medical students), one Family Medicine teaching service (mix of FM and IM attendings with three FM residents), one Medical Oncology teaching service, which works closely with Oncology to provide inpatient care to patients with solid tumors, three non-resident services (each staffed by an attending and physician assistant), a Medicine Consult service, and a triage attending. In addition, each night we have two Nocturnists (and intermittent physician assistant coverage), who provide cross-coverage care and perform admissions for both the teaching and

non-resident services along with medical consults, Rapid Response Team coverage, and outside hospital triage. We continue to expand our use and teaching of bedside ultrasound techniques under the expert guidance of Drs. Mohit Jindal and Tara Scribner. The AHMS faculty had an especially busy year caring for potential and confirmed COVID-19 patients. Our Hospitalists have been engaged in numerous institutional quality improvement and safety initiatives. Our current project focuses on standardizing venous thromboembolism prophylaxis use in medical inpatients. In the last few years, we have also significantly reduced the rate of hyperglycemia, reduced the number of unnecessary labs performed on our inpatients, improved the completion of accurate problem lists at the time of discharge, improved communication with primary care at discharge, and decreased the wait time of orders for patients admitted through the Emergency Department. Education: Our faculty teaches General Internal Medicine and Hospital Medicine to medical students, resident physicians, professional colleagues, and community members. Dr. Mark Pasanen is the Vice Chair for Education in the Department of Medicine. Hospitalists serve as the teaching attending for the six teaching teams throughout the year – offering clinical supervision, bedside and didactic education, and feedback and evaluation to resident physicians and medical students. At night, our Nocturnists provided supervision and education for our night residents and 4th year medical students. Additionally, our inpatient faculty physicians lead the Medicine Consult elective for residents and medical students, which includes residents from Orthopedic Surgery. Our faculty are regular participants and facilitators at Resident Report and Intern Report. Dr. Julia Powelson provided outstanding leadership in our Adult Code training for our residents. Dr. Jason Bartsch has helped develop the Hospital Medicine academic half-day resident curriculum in which multiple hospitalists participate. Dr. Amanda Kennedy oversees our comprehensive Internal Medicine Resident research program, Dr. Carrie Lyon is a member of the Resident Research Committee, and Dr. Naomi Hodde was a mentor for a resident research project. Dr. Rachel McEntee provides high level education on Epic use, including directing Epic Sprints for attendings and APPs and didactic sessions for resident physicians and medical students. Dr. Mark Pasanen is the Program Director for the Internal Medicine Residency. Our faculty members have been recognized numerous times by the resident physicians for teaching excellence. Most recently, Dr. Caleb Burr received the Mark A. Levine Award for Outstanding Teacher of the Year in General Internal Medicine in 2021.

At the Larner College of Medicine, our primary teaching is in the hospital setting, focusing on the Internal Medicine Inpatient Clerkship and the Internal Medicine Acting Internship. Dr. Jason Bartsch serves as Assistant Clerkship Director and serves on the Active Learning Advisory Committee. Dr. Lee-Anna Burgess is the Assistant Acting Internship Director. Dr. Lee-Anna Burgess also serves as the course director for the Nutrition, Metabolism, and GI course. Dr. Elly Riser is the course director for the first Addiction Medicine elective at LCOM. Drs. Maria Burnett, Lee-Anna Burgess, Carrie Lyon, Rachel McEntee, Sadie Mills, Mark Pasanen, Tara Scribner, and Paul Slavik teach in the Foundations courses, Drs. Maria Burnett, Carrie Lyon, and Mark Pasanen teach in the Convergence course, and Drs. Naomi Hodde and Paul Slavik are faculty mentors in the Professionalism, Communication and Reflection course. Dr. Naomi Hodde also teaches 3rd year medical students during their bridge weeks. We educate our colleagues locally, regionally and nationally in a variety of venues. This past year our annual University of Vermont Continuing Medical Education Course in Hospital Medicine was canceled due to COVID, but our course directors, Drs. Carrie Lyon, Steve Grant and Jason Bartsch are looking forward to 2022. The AHMS faculty are also very involved in mentorship and advising. This includes advising numerous medical students on career choice and residency match issues. Residents also frequently seek out our Hospitalists to serve as advisors, especially those going into the growing field of Hospital Medicine. Research: In addition to our clinical work and focus on quality and safety, we have diverse scholarly interests among our faculty. This has included externally funded clinical trials of immunizations and high value laboratory ordering practices. In addition, internal funding has supported Dr. Elly Riser’s work on teaching trainees about opioid use disorder and medication assisted treatment. Dr. Elie Donath works with the UVM Complex Systems Group, the UVM Computer Science Department, and the Gund Institute on several projects looking at artificial intelligence in medicine and public health. Quality: Our Division is very involved in quality initiatives throughout the institution. Dr. Allen Repp is the Department’s Vice Chair for Quality. Dr. Preetika Muthukrishnan and Maria Burnett lead our Division quality improvement work, which includes optimizing use of the electronic health record and communication and work on venous thromboembolism prevention in the hospital. Drs. Zech Gardner, Preetika Muthukrishnan, and Naomi Hodde are physician leaders for the hospital’s Collaborative Leadership Model. Dr. Yao Li provides support and education around information technology and Epic use. Leadership:

Hospital Medicine faculty members are engaged in service at the national, state and institutional levels. National and regional involvement includes the OneCare Vermont Clinical Advisory Board, Vermont Chapter for the American College of Physicians (past Governors and several members of the advisory council membership) and past president of the UVM Medical Alumni Executive Committee. Faculty participation in committees and task forces at the Larner College of Medicine and the University of Vermont Medical Center is also wide-ranging. Highlights include leadership and/or participation on the Tenure and Promotions committee, Medical Executive committee, Rapid Response and Resuscitation committee, Unit-based Care leadership, Hospital Operations, Quality Improvement, Ethics, COVID-19 response committees, and EPIC/IT. There are numerous specific examples of leadership within the faculty. Dr. Steven Grant serves as the Associate Chief Medical Officer for Care Coordination and Patient Transitions. Drs. Steve Grant and Zech Gardner chair the Hospital Operations committee. Drs. Chad Mitchell, Zech Gardner, Mohit Jindal and Steve Grant serve a critical role in Utilization Review, providing real-time reviews in coordination with Case Management. Dr. Rachel McEntee has been instrumental in helping to optimize EPIC, our electronic health record, through her role as Director of Medical Informatics. Dr. Preetika Muthukrishnan is the Medical Director of the Emergency Response Team. Dr. Dr. Allen Repp serves as Vice Chair of Quality for the Department of Medicine. Dr. Mark Pasanen is the Internal Medicine Residency Program Director and Vice Chair for Education in the Department of Medicine. We have worked closely with other departments in an effort to optimize patient care. This has included co-management arrangements with the Orthopedics Hip Fracture, Spine, and Podiatry services. We have also developed a shared model of care with the Renal Transplant Service and Ophthalmology. In addition, Drs. Gardner, Muthukrishnan and Hodde serve as Unit-Based Leaders for our General Medical and Oncology units. Faculty/Members of the Division of Hospital Medicine: Jason Bartsch, MD Assistant Professor of Medicine Director of Medical Education, Division of Hospital Medicine Assistant Clerkship Director, Department of Medicine Brittany Bryan, PA Lee-Anna Burgess, MD Assistant Professor of Medicine Assistant Acting Internship Director, Department of Medicine Course Director, Nutrition, Metabolism, and GI, LCOM

Maria Burnett, MD, MS Assistant Professor of Medicine Co-Director of Quality and Safety, Division of Hospital Medicine Caleb Burr, MD Assistant Professor of Medicine Alejandro Castro, MD Assistant Professor of Medicine Jennifer Clauss, PA Markus Degirmenci, MD Assistant Professor of Medicine Elie Donath, MD Assistant Professor of Medicine Florian Foerg, MD Assistant Professor of Medicine Director, Hospital Medicine Consult and Co-management Service Jon Ford, PA Zechariah Gardner, MD Assistant Professor of Medicine Associate Division Chief, Division of Hospital Medicine Medical Director, Baird 3 CLM Co-chair, Hospital Operations Nadia Ghallab, MD Assistant Professor of Medicine Steven Grant, MD Associate Professor of Medicine Associate Chief Medical Officer for Care Coordination and Patient Transitions Sonali Herath, PA Naomi Hodde, MD Assistant Professor of Medicine Medical Director, Miller 5 CLM

Mohit Jindal, MD Assistant Professor of Medicine Director of Ultrasound Education, Division of Hospital Medicine Peter Kaminski, MD Assistant Professor of Medicine Amanda Kennedy, PharmD Associate Professor of Medicine Chair, Internal Medicine Residency Research Committee Department of Medicine Quality Scholar Erin Kurek, MD, MPH Assistant Professor of Medicine Shea Lambirth, MD Assistant Professor of Medicine Griffin Latulippe, PA Yao (Jim) Li, MD Assistant Professor of Medicine Informatacist Caroline Lyon, MD, MPH Associate Professor of Medicine Division Chief, Division of Hospital Medicine Director, Hospital Medicine CME course Rachel McEntee, MD Assistant Professor of Medicine Director, Medical Informatics Sadie Mills, MD Assistant Professor of Medicine Chad Mitchell, MD Assistant Professor of Medicine Preetika Muthukrishnan, MD Assistant Professor of Medicine Medical Director, McClure 6 CLM Medical Director, Emergency Response Team Co-Director of Quality and Safety, Division of Hospital Medicine

Melissa Naef, PA Mark Pasanen, MD Associate Professor of Medicine Program Director, Internal Medicine Residency Program Vice Chair for Education, Department of Medicine Allen Repp, MD, MS Professor of Medicine Vice Chair for Quality, Department of Medicine Elly Riser, MD Assistant Professor of Medicine Tara Scribner, MD Assistant Professor of Medicine Paul Slavik, MD Assistant Professor of Medicine Michael Stutzman, MD Assistant Professor of Medicine Eric Westphal, PA Dennis Woods, MD Assistant Professor of Medicine Editorships and Editorial Boards: Allen Repp, MD, MS Reviewer:

• Journal of Hospital Medicine • Journal for Healthcare Quality • Journal of General Internal Medicine • Academic Medicine • The Joint Commission Journal on Quality and Patient Safety

Zech Gardner, MD Reviewer:

• British Medical Journal Open Quality

Major Faculty Awards: Caleb Burr, MD was the recipient of the Mark A. Levine, M.D. Award for Outstanding Teacher of the Year in General Internal Medicine Dr. Preetika Muthukrishnan won the Department of Medicine Quality Scholarship Award Dr. Elly Riser was awarded the top medical innovations abstract for her work in addiction medicine education at the Society of General Internal Medicine Mountain West/New England Virtual Regional Meeting on November 6, 2020. Publications – peer reviewed, chapters, etc. (not abstracts) Bolton K, Lawler M, Hauptman J, Madden M, DeVoe S, Kennedy A, Tomkins B, Hodde NM. Patient experience on a hospital oncology service before and after implementation of a no-visitor policy during Covid-19. Journal of Patient Experience, 2021.

Lozier M, Pachon R, Lee J, Sanchez AM, Donath E, Osman AF. Long-term clinical outcomes and prognostic indicators for focal impulse and rotor modulation guided ablation: a single center observational study. J Electrocardiology. 2020;61:153-159. PMID:32623257

Gajeda E, Pino J, Donath E, Torres P, CHait R, Ghumman W. Impella to unload the left ventricle in patients undergoing venoarterial extracorporeal membrane oxygenation for cardiogenic shock: a systematic review and meta-analysis. J Card Surg. 2020;35(6):1237-1242. PMID: 32531130

Pino J, Shah V, Ramos Tuarez F, Kreidieh O, Donath E, Lovitz L, Rothenberg M, Cubeddu R, Nores M, Chait R. The utility of pulmonary function testing in the preoperative risk stratification of patients undergoing transcatheter aortic valve replacement. Catheter Cardiovasc Interv. 2020 1;95(6):179:185. PMID: 31313472

Riser E, Holterman LH, Maruti S, Brooklyn JR, DeVoe SG, Tompkins BJ, Drouin J, Sobel HG. Integrating Addiction Medicine into undergraduate medical education: the time is now. Substance Abuse. 06 April 2021; 42(2):236-243. Muthukrishnan P, Burnett M, Devoe S, Kennedy A, Pasanen M, Tompkins B, Repp A. An active-learning quality improvement curriculum for faculty in Hospital Medicine. J Contin Educ Health Prof. Apr 2021. PMID 33929351 Ricotta D, Hale A, Freed J, Scribner T, Zeidel M, Herzig S. Generalists as clinical physiologists: bring science back to the bedside. J Gen Int Med. 2021.

Presentations: Dr. Naomi Hodde:

1. “TalkVermont: A Practical Approach to SeriousIllness Conversation”, UVM Family Medicine Conference, October 5, 2020

2. “Life and Loss in Rural Uganda”, Global Health Open Forum, December, 2020.

Dr. Elly Riser: 1. “Integrating Addiction Medicine into Undergraduate Education: The Time is

Now”; Society of General Internal Medicine Mountain West/New England Virtual Regional Meeting. November 6, 2020

2. “Innovative Learning and Teaching About Substance Use/Opioid Use Disorder”, Coalition on Physician Education in Substance Use Disorders Virtual Meeting, January 21, 2021

3. “Transforming our communities; supporting people who use drugs”, Addictions, Drug, and Alcohol Institute of the University of Washington Virtual Meeting, June 30, 2021.

Division of Immunobiology Ralph Budd, MD, Director http://www.med.uvm.edu /medicine/immunobiology http://www.med.uvm.edu/vciid

The Division of Immunobiology currently has five research faculty and two graduate students. Research covers a variety of areas, including the immune response to infections and vaccines, virus-host interactions, autoimmune mechanisms, and inflammation in cancer. Research support includes numerous individuals grants as well as a Center of Biomedical Research Excellence (COBRE) Award from NIH. Now in its 15th year, the COBRE grant supports the activities of the Vermont Center for Immunology and Infectious Diseases (VCIID), which now numbers 25 faculty in 8 departments in 3 colleges and is in close alliance with the Vaccine Testing Center. The VCIID has a weekly joint Research-in-

Progress meeting, seminar series, and a journal club. This provides a regular forum for students and postdoctoral fellows to present their research progress as well as for faculty to review hypotheses and specific aims of planned grants. During the first 10 years of COBRE funding, VCIID faculty published 419 articles and received over $92 million in funding. This also provided funds to allow the College of Medicine to build a new BSL3 facility in partnership with the Vermont Department of Health, and to recruit new faculty to the theme of the host response to infection. We also have a T32 Training Grant from NIH, also in its 15th year, to support the salaries of our graduate students. Faculty Ralph Budd, MD University Distinguished Professor of Medicine and Microbiology & Molecular Genetics Director, Vermont Center of Immunology & Infectious Diseases

• Key Research Interests: Autoimmune mechanisms, immune cell death, Lyme arthritis, caspase regulation, immune metabolism, γδ T cells

• Clinical interests in autoimmune diseases

Jason Botten, PhD Professor of Medicine, Adjunct in Microbiology and Molecular Genetics

• Key Research Interests: Identification of key virus-host interactions required for viruses (e.g. arenaviruses, flaviviruses, coronaviruses hantaviruses) to complete their life cycle and/or cause human disease; understanding how host-driven posttranslational modifications (e.g. phosphorylation) of viral proteins regulate their functionality; understanding the natural history of host T and B cell responses to virus infection and how these immune cells contribute to protective immunity or immune-mediated pathogenesis; viral diagnostics; translating our basic science discoveries into vaccines and therapeutics.

Allison Falcone, DVM Faculty Scientist

• Key Research Interests: Animal models of viral infection, A/BSL-3 studies, development of medical countermeasures for pathogenic RNA viruses (SARS-CoV-2, hantaviruses, arenaviruses)

Cory Teuscher, PhD Professor of Medicine and Pathology

• Key Research Interests: Immunogenetics of animal models of autoimmune and infectious disease

Tina Thornton, PhD Assistant Professor of Medicine

• Key Research Interests: Understanding motivation and ways to promote biomedical entrepreneurship and research commercialization, Understanding the interactions of signaling pathways that control early thymocyte development and survival, the interaction of the p38 MAPK pathway and GSK3 in the context of DNA damage signaling.

Graduate Students, Post-doctoral Fellows, MD PhD Students and brief statement on their research study: Annalis (Norman) Whitaker (graduate student) – Identification of human monoclonal antibodies for treatment of hantavirus and COVID-19 disease in humans; identification of key host proteins required for arenavirus propagation. Inessa Manuelyan (graduate student) – Identification of key human proteins and host-drive post-translational modifications of viral proteins required for flavivirus and coronavirus propagation.

Leadership in Professional Societies: (Budd) Advisory Committee, New England Immunology Society Editorships and Editorial Boards: (Budd) Senior Editor for “Textbook of Rheumatology” 11th Edition, Elsevier (Botten) Editor for Frontiers in Microbiology Study Sections and Federal Advisory Boards: Budd: 2020 T32 Grant Reviews AITC NIAID 2020 NIH Immunity and Host Defense 2020 ZGM1 RCB-9 COBRE Phase I Grant Review NIGMS 2021 ACTS (Arthritis, Connective Tissue, and Skin Biology Section) Botten: 2020 Topics in Drug Discovery and Clinical Field Studies (ZRG1 IDM-N (02) Special Emphasis

Panel, NIH /NIAID, Ad hoc reviewer 2021 NIH/NIAID Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section

DDR, Ad hoc reviewer Teuscher: 2021 National Institutes of Health, ZRG1 BDCN-W (03) 2021 National Institutes of Health, NIGMS ZGM1 RCB-2 (C1) 2021 Reviewer, for applications in response to PAR-20-177 and PAR-20-178, “Emergency

Awards: Rapid Investigation of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Coronavirus Disease 2019 (COVID-19)

Permanent member, grant review panel for the National Multiple Sclerosis Society Major Faculty / Research Awards:

(Botten) Promoted to Professor of Medicine (Tenure)

(Botten) Recipient of the 2020 UVM LCOM Dean’s Mid-Career Investigator Award

(Botten) Nominated for the 2020 UVM Department of Medicine Distinguished Mentor Award

(Botten) Chaired a Breakout Session at the 2020 American Society of Virology Meeting.

(Botten) Keynote speaker at the Northeast Regional Laboratory Staff and Core Directors Meeting.

(Botten) Co-founding member of the PROPAGATE Network, an international team of scientists and regulatory officials working to increase global COVID-19 testing and screening capacity

(Botten) Founding Scientific Advisory Board member for the Pandemic Security Initiative, a public-private partnership working to prepare the United States for future pandemics through the proactive development of innovative diagnostics, vaccines, and therapeutics

(Botten) PhD students Inessa Manuelyan and Annalis Whitaker each received travel awards for the 2021 American Society of Virology Meeting. Annalis, Inessa, and Dr. Botten each gave talks at this meeting

Grants – list all active by faculty member, PI Budd: P30 GM118228 Budd (PI)

Title: Vermont Immunology / Infectious Diseases Center Dates of Award: 08/05/2016 – 07/31/22 Role: PI Current Yr funding: $1,165,985 Source: NIH/NIGMS

P30 GM118228-S1 Budd (PI) Title: Alzheimer’s-focused Administrative supplement Dates of Award: 08/01/2020 – 07/31/22 Role: PI Current Yr funding: $390,000 Source: NIH/NIGMS

P30 GM118228-S2 Budd (PI) Title: Administrative Supplement for Research on Women's Health in the IDeA States Dates of Award: 08/01/2020 – 07/31/22 Role: PI Current Yr funding: $312,000 Source: NIH/NIGMS

R21 AI151407 Budd (PI)

Title: Ligands for Human Synovial Gamma-Delta T Cells Dates of Award: 04/06/2020-03/31/22 Role: PI Current Yr funding: $241,753 Source: NIH/NIAID

T32 AI 055402 Budd (PI) Title: Vermont Immunology / Infectious Diseases Training Grant Dates of Award: 09/01/05 – 08/31/21 Role: PI Current Yr funding: $197,789 Source: NIH/NIAID Botten:

R41AI132047 (STTR) (Botten, J.) 08/08/2017-07/31/2021 NIH/NIAID Therapeutic antibodies for treatment of hantavirus cardiopulmonary syndrome Major goal is to capture the repertoire of antibodies generated against Andes hantavirus during acute infection and identify those that could be used to therapeutically treat

disease. Total costs of UVM sub with indirect costs: $0 No Cost Extension R21AI154198 (Botten, J.) 06/01/2020-05/31/2022 NIH/NIAID Title: Deep sequencing the lymphocytic choriomeningitis arenavirus quasi species to identify and functionally validate the molecular signature of defective interfering particles Major goal is to map the phosphorylation sites on the arenavirus proteome and

determine which modifications regulate the functionality of arenavirus proteins. Total costs with indirect costs: $444,347 1R43AI142911-01 (SBIR) (Botten, J., Co-PI) 01/01/2019-12/31/2021 NIH/NIAID A novel antibody therapy for Sin Nombre virus infection Major goal is to capture the repertoire of antibodies generated against Sin Nombre hantavirus during acute infection and identify those that could be used to therapeutically treat disease. Total costs of UVM Sub with indirect costs: $0 No Cost Extension 1U01AI141997-01 (Botten, J., MPI) 02/01/19-01/31/24

NIH/NIAID Mechanisms of Protection and Durability for a Live Attenuated Tetravalent Dengue Vaccine Tetravalent dengue vaccination must offer safe and durable protection against all four serotypes of dengue viruses. We leverage four vaccine trials and viral challenges

evaluating the NIH dengue vaccine to explore and confirm immune mechanisms associated with protection. Total costs with indirect costs: $695,490

R41 AI157527 (Botten, J., Co-PI) 01/01/2021-12/31/2022 NIH/NIAID

A Novel Broad-spectrum Antiviral Agent The primary purpose of this project is for Dr. Botten’s lab to perform hybridoma screening for SARS-CoV-2 and Junin viral neutralization – white plate assay and IC50. Total costs of UVM Sub with indirect costs: $131,736

Jet Propulsion (Botten, J.,PI) 06/01/2020-07/31/2021 Screening of novel anti-SARS-CoV-2 peptides for infection of Vero E6 cells with SARS- CoV-2

The goal of this project is to test a library of peptides for their ability to inhibit SARS-CoV- 2 growth.

Total costs with indirect costs: $100,000

IGM Biosciences (Botten, J.,PI) 07/14/2020-11/31/2021 SARS CoV-2 Neutralization Assay of Proof of Concept Multimeric Antibodies The purpose of this phase is to establish methodologies and determine the feasibility of performing live SARS-CoV-2 viral neutralization assays with purified antibodies or culture supernatants containing these antibodies.

Total costs with indirect costs: $410,455 IGM Biosciences (Botten, J.,PI) 03/01/2021-2/22/2022 In-Vivo Efficacy Testing of Human Monoclonal Antibodies The purpose of this project is for Dr. Botten’s lab to establish 3 murine models of SARS- CoV-2 infection to test the efficacy of human monoclonal antibodies (mAbs) for inhibition of viral replication and disease pathogenesis. Total costs with indirect costs: $357,557 Atreca (Botten, J.,PI) 11/02/2020-11/01/2021

Mapping the repertoire of human antiviral antibodies during acute SARS-CoV-2 infection

The purpose of this project is for Dr. Botten’s lab to perform functional testing on human mAbs derived from COVID-19 plasmablasts as well as plasma or serum from these same donors.

Total costs with indirect costs: $315,625 Teuscher:

R01 NS097596 (Krementsov D, PI) 03/15/2017-01/31/2022 NIH Interactions Between Host Genetics and the Gut Microbiome in CNS Autoimmunity Annual Direct Costs: $218,750 Teuscher Effort: 5% RG-1807-31533 (Krementsov D, PI) 10/01/2019-09/30/2022 NMSS Next generation systems analysis of pathogenetic mechanisms underlying CNS autoimmunity using the Collaborative Cross Annual Direct Costs: $38,152 Teuscher Effort: 5% P30 GM118228-05S2 (Budd R, PI) Teuscher C (Lead Contact) 08/01/2020-07/31/2021 NIH/NIGMS Vermont Immunology/Infectious Disease Center Supplement in response to NOT-GM-20-017: Administrative Supplements for Research on Women’s Health in the IDeA States Annual Direct Costs: $200,000 Teuscher Effort: 11% R21 AI152556-01A1 (Bonney E, PI) 05/21/2021-04/30/2022 NIH/NIAID Mechanistic Analyses of the Genetic Variation of Preterm Birth Using the Collaborative Cross Mice Annual Direct Costs: $153,009 Teuscher Effort: 10% R01 DK113800 (Mawe G, PI) Teuscher C (Co-PI) 09/20/17-08/31/21 NIH/NIDDKD Autoimmune Mechanisms of Gastrointestinal Dysmotility in Multiple Sclerosis The goals for this project are to test the hypotheses that 1) gastrointestinal motility is disrupted in EAE mice and determine whether this function involves antibody production by B-lymphocytes, 2) human MS and murine EAE serum samples contain autoantibodies that target enteric neuronal and/or glial cell proteins, 3) activities of colonic enteric glial cells and neurons are disrupted in EAE mice and by exposure to MS serum samples and 4) existing treatments for constipation or for EAE somatic symptoms can restore intestinal motility in EAE mice.

Direct Costs: $298,106

Publications – peer reviewed, chapters, etc. (not abstracts):

Crothers JW, Chu ND, Nguyen LTT, Phillips M, Collins C, Fortner K, Del Rio-Guerra R, Lavoie B, Callas P, Velez M, Cohn A, Elliott RJ, Wong WF, Vo E, Wilcox R, Smith M, Kassam Z, Budd R, Alm EJ, Mawe GM, Moses PL. Daily, oral FMT for long-term maintenance therapy in ulcerative colitis: results of a single-center, prospective, randomized pilot study. BMC Gastroenterol. 2021 Jul 8;21(1):281. doi: 10.1186/s12876-021-01856-9. PubMed PMID: 34238227; PubMed Central PMCID: PMC8268596.

Rissanen I, Krumm SA, Stass R, Whitaker A, Voss JE, Bruce EA, Rothenberger S, Kunz S, Burton DR, Huiskonen JT, Botten JW, Bowden TA, Doores KJ. Structural Basis for a Neutralizing Antibody Response Elicited by a Recombinant Hantaan Virus Gn Immunogen. mBio. 2021 Jul 6;:e0253120. doi: 10.1128/mBio.02531-20. [Epub ahead of print] PubMed PMID: 34225492

Montgomery TL, Paavola M, Bruce EA, Botten JW, Crothers JW, Krementsov DN. Laboratory Worker Self-Contamination with Noninfectious SARS-CoV-2 DNA Can Result in False-Positive Reverse Transcriptase PCR-Based Surveillance Testing. J Clin Microbiol. 2021 Jun 18;59(7):e0072321. doi: 10.1128/JCM.00723-21. Epub 2021 Jun 18. PubMed PMID: 33952597.

Giddings EL, Champagne DP, Wu MH, Laffin JM, Thornton TM, Valenca-Pereira F, Culp-Hill R, Fortner KA, Romero N, East J, Cao P, Arias-Pulido H, Sidhu KS, Silverstrim B, Kam Y, Kelley S, Pereira M, Bates SE, Bunn JY, Fiering SN, Matthews DE, Robey RW, Stich D, D'Alessandro A, Rincon M. Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance. Nat Commun. 2021 May 14;12(1):2804. doi: 10.1038/s41467-021-23071-6. PubMed PMID: 33990571; PubMed Central PMCID: PMC8121950.

Mills MG, Bruce E, Huang ML, Crothers JW, Hyrien O, Oura CAL, Blake L, Jordan AB, Hester S, Wehmas L, Mari B, Barby P, Lacoux C, Fassy J, Vial P, Vial C, Martinez JRW, Oladipo OO, Inuwa B, Shittu I, Meseko CA, Chammas R, Santos CF, José Dionísio T, Garbieri TF, Parisi VA, Mendes-Correa MC, dePaula AV, Romano CM, Góes LGB, Minoprio P, Campos AC, Cunha MP, Vilela APP, Nyirenda T, Mkakosya RS, Muula AS, Dumm RE, Harris RM, Mitchell CA, Pettit S, Botten J, Jerome KR. An international, interlaboratory ring trial confirms the feasibility of an open-source, extraction-less "direct" RT-qPCR method for reliable detection of SARS-CoV-2 RNA in clinical samples. medRxiv. 2021 Apr 16;. doi: 10.1101/2021.04.10.21254091. PubMed PMID: 33880478; PubMed Central PMCID: PMC8057246.

Calvo B, Thornton TM, Rincon M, Tranque P, Fernandez M. Regulation of GSK3β by Ser389 Phosphorylation During Neural Development. Mol Neurobiol. 2021 Feb;58(2):809-820. doi: 10.1007/s12035-020-02147-2. Epub 2020 Oct 8. PubMed PMID: 33029741.

Tu HA, Nivarthi UK, Graham NR, Eisenhauer P, Delacruz MJ, Pierce KK, Whitehead SS, Boyson JE, Botten JW, Kirkpatrick BD, Durbin AP, deSilva AM, Diehl SA. Stimulation of B Cell Immunity in Flavivirus-Naive Individuals by the Tetravalent Live Attenuated Dengue Vaccine TV003. Cell Rep Med. 2020 Dec 22;1(9):100155. doi: 10.1016/j.xcrm.2020.100155. eCollection 2020 Dec 22. PubMed PMID: 33377126; PubMed Central PMCID: PMC7762770.

Banerjee AK, Blanco MR, Bruce EA, Honson DD, Chen LM, Chow A, Bhat P, Ollikainen N, Quinodoz SA, Loney C, Thai J, Miller ZD, Lin AE, Schmidt MM, Stewart DG, Goldfarb D, De Lorenzo G, Rihn SJ, Voorhees RM, Botten JW, Majumdar D, Guttman M. SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses. Cell. 2020 Nov 25;183(5):1325-1339.e21. doi: 10.1016/j.cell.2020.10.004. Epub 2020 Oct 8. PubMed PMID: 33080218; PubMed Central PMCID: PMC7543886.

Montgomery TL, Künstner A, Kennedy JJ, Fang Q, Asarian L, Culp-Hill R, D'Alessandro A, Teuscher C, Busch H, Krementsov DN. Interactions between host genetics and gut microbiota determine susceptibility to CNS autoimmunity. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27516-27527. doi: 10.1073/pnas.2002817117. Epub 2020 Oct 19. PubMed PMID: 33077601; PubMed Central PMCID: PMC7959502.

Lahue KG, Lara MK, Linton AA, Lavoie B, Fang Q, McGill MM, Crothers JW, Teuscher C, Mawe GM, Tyler AL, Mahoney JM, Krementsov DN. Identification of novel loci controlling inflammatory bowel disease susceptibility utilizing the genetic diversity of wild-derived mice. Genes Immun. 2020 Nov;21(5):311-325. doi: 10.1038/s41435-020-00110-8. Epub 2020 Aug 26. PubMed PMID: 32848229; PubMed Central PMCID: PMC7657953.

Scharer CD, Fortner KA, Dragon JA, Tighe S, Boss JM, Budd RC. Selective DNA Demethylation Accompanies T Cell Homeostatic Proliferation and Gene Regulation in Lupus-Prone lpr Mice. Immunohorizons. 2020 Oct 23;4(10):679-687. doi: 10.4049/immunohorizons.2000078. PubMed PMID: 33097564; PubMed Central PMCID: PMC8141279.

Graham NR, Whitaker AN, Strother CA, Miles AK, Grier D, McElvany BD, Bruce EA, Poynter ME, Pierce KK, Kirkpatrick BD, Stapleton RD, An G, van den Broek-Altenburg E, Botten JW, Crothers JW, Diehl SA. Kinetics and isotype assessment of antibodies targeting the spike protein receptor-binding domain of severe acute respiratory syndrome-coronavirus-2 in COVID-19 patients as a function of age, biological sex and disease severity. Clin Transl Immunology. 2020;9(10):e1189. doi: 10.1002/cti2.1189. eCollection 2020. PubMed PMID: 33072323; PubMed Central PMCID: PMC7541824.

Bruce EA, Huang ML, Perchetti GA, Tighe S, Laaguiby P, Hoffman JJ, Gerrard DL, Nalla AK, Wei Y, Greninger AL, Diehl SA, Shirley DJ, Leonard DGB, Huston CD, Kirkpatrick BD, Dragon JA, Crothers

JW, Jerome KR, Botten JW. Direct RT-qPCR detection of SARS-CoV-2 RNA from patient nasopharyngeal swabs without an RNA extraction step. PLoS Biol. 2020 Oct;18(10):e3000896. doi: 10.1371/journal.pbio.3000896. eCollection 2020 Oct. PubMed PMID: 33006983; PubMed Central PMCID: PMC7556528.

Gergi M, Cushman M, Littenberg B, Budd RC. Thrombo-inflammation response to Tocilizumab in COVID-19. Res Pract Thromb Haemost. 2020 Sep 25;. doi: 10.1002/rth2.12436. [Epub ahead of print] PubMed PMID: 33043232; PubMed Central PMCID: PMC7537313.

Vial C, Whitaker A, Wilhelm J, Ovalle J, Perez R, Valdivieso F, Ferres M, Martinez-Valdebenito C, Eisenhauer P, Mertz GJ, Hooper JW, Botten JW, Vial PA. Comparison of VSV Pseudovirus and Focus Reduction Neutralization Assays for Measurement of Anti-Andes orthohantavirus Neutralizing Antibodies in Patient Samples. Front Cell Infect Microbiol. 2020;10:444. doi: 10.3389/fcimb.2020.00444. eCollection 2020. PubMed PMID: 33042854; PubMed Central PMCID: PMC7527604.

Drayman N, Jones KA, Azizi SA, Froggatt HM, Tan K, Maltseva NI, Chen S, Nicolaescu V, Dvorkin S, Furlong K, Kathayat RS, Firpo MR, Mastrodomenico V, Bruce EA, Schmidt MM, Jedrzejczak R, Muñoz-Alía MÁ, Schuster B, Nair V, Botten JW, Brooke CB, Baker SC, Mounce BC, Heaton NS, Dickinson BC, Jaochimiak A, Randall G, Tay S. Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro. bioRxiv. 2020 Sep 1;. doi: 10.1101/2020.08.31.274639. PubMed PMID: 32908976; PubMed Central PMCID: PMC7480023.

Graham NR, Whitaker AN, Strother CA, Miles AK, Grier D, McElvany BD, Bruce EA, Poynter ME, Pierce KK, Kirkpatrick BD, Stapleton RD, An G, Botten JW, Crothers JW, Diehl SA. Kinetics and Isotype Assessment of Antibodies Targeting the Spike Protein Receptor Binding Domain of SARS-CoV-2 In COVID-19 Patients as a function of Age and Biological Sex. medRxiv. 2020 Jul 16;. doi: 10.1101/2020.07.15.20154443. PubMed PMID: 32743592; PubMed Central PMCID: PMC7386516.

**Ziegler CM, Botten JW. Defective Interfering Particles of Negative-Strand RNA Viruses. Trends Microbiol. 2020 Jul;28(7):554-565. doi: 10.1016/j.tim.2020.02.006. Epub 2020 Mar 26. Review. PubMed PMID: 32544442; PubMed Central PMCID: PMC7298151. ** Note our submitted electron micrograph of virus particles budding was selected as the cover photo for this issue.

Pettit SD, Jerome KR, Rouquié D, Mari B, Barbry P, Kanda Y, Matsumoto M, Hester S, Wehmas L, Botten JW, Bruce EA. 'All In': a pragmatic framework for COVID-19 testing and action on a global scale. EMBO Mol Med. 2020 Jun 8;12(6):e12634. doi: 10.15252/emmm.202012634. Epub 2020 May 27. PubMed PMID: 32375201; PubMed Central PMCID: PMC7267598.

Fortner KA, Blanco LP, Buskiewicz I, Huang N, Gibson PC, Cook DL, Pedersen HL, Yuen PST, Murphy MP, Perl A, Kaplan MJ, Budd RC. Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL-lpr mice. Lupus Sci Med. 2020

Apr;7(1). doi: 10.1136/lupus-2020-000387. Epub 2020 Apr 16. PubMed PMID: 32343673; PubMed Central PMCID: PMC7199895.

Bruce EA, Huang ML, Perchetti GA, Tighe S, Laaguiby P, Hoffman JJ, Gerrard DL, Nalla AK, Wei Y, Greninger AL, Diehl SA, Shirley DJ, Leonard DGB, Huston CD, Kirkpatrick BD, Dragon JA, Crothers JW, Jerome KR, Botten JW. DIRECT RT-qPCR DETECTION OF SARS-CoV-2 RNA FROM PATIENT NASOPHARYNGEAL SWABS WITHOUT AN RNA EXTRACTION STEP. bioRxiv. 2020 Apr 6;. doi: 10.1101/2020.03.20.001008. PubMed PMID: 32511328; PubMed Central PMCID: PMC7239058.

Clement J, Ahlm C, Avšič-Županc T, Botten J, Chandran K, Jonsson CB, Kariwa H, Klingström J, Klempa B, Krüger DH, Leirs H, Li D, Liang M, Markotić A, Papa A, Schmaljohn CS, Tischler ND, Ulrich RG, Vaheri A, Vial C, Yanagihara R, Maes P. Meeting report: Eleventh International Conference on Hantaviruses. Antiviral Res. 2020 Apr;176:104733. doi: 10.1016/j.antiviral.2020.104733. Epub 2020 Feb 15. Review. PubMed PMID: 32068071.

Drayman N, Jones KA, Azizi SA, Froggatt HM, Tan K, Maltseva NI, Chen S, Nicolaescu V, Dvorkin S, Furlong K, Kathayat RS, Firpo MR, Mastrodomenico V, Bruce EA, Schmidt MM, Jedrzejczak R, Muñoz-Alía MÁ, Schuster B, Nair V, Botten JW, Brooke CB, Baker SC, Mounce BC, Heaton NS, Dickinson BC, Jaochimiak A, Randall G, Tay S. Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro. Science (In Press)

Division of Infectious Diseases Annual Report July 2020–June 2021 W. Kemper Alston, MD, MPH, Division Chief http://www.uvm.edu/medicine/medicine/infectiousdisease/

The Infectious Diseases (ID) Division is comprised of twelve attending physicians and 3 mid-level providers on the Burlington campus dedicated to the diagnosis, management, prevention and investigation of infectious diseases. Obviously, this past year was defined by the COVID–19 pandemic. The ID division played a key role in the UVMMC response and worked

closely with Employee Health and Infection Prevention to care for patients and protect staff. We collaborated with the Medical Center, the Network, and the state of Vermont. Meanwhile, the division carried on with its day to day work, providing outstanding patient care for those in the hospital as well as in the clinic and throughout the State, teaching fellows, residents, students, colleagues, and the community, performing cutting edge research, and providing administrative support for a variety of hospital functions. The ID Division performs about 150 inpatient consultations a month. We also staff a busy outpatient clinic seeing new consultations, hospital follow-ups, and caring for travelers, those living with HIV, hepatitis C, tuberculosis and refugees, among others. This effort includes the care of over 500 patients with HIV in four federally funded Comprehensive Care Clinics located in Burlington, Brattleboro, Rutland, and St. Johnsbury. The Division has contracts with the Vermont Department of Health to collaborate on antibiotic stewardship, tuberculosis, and biological and pandemic preparedness. The Division has a contract with the VT Department of Corrections to consult on hepatitis C. The ID staff includes the Chair of the Department of Microbiology and Molecular Genetics in the College of Medicine, the UVM Medical Center Hospital Epidemiologists and Director of Infection Prevention, the Director of Pandemic Preparedness, a Vice Chair of Medicine, the Director of Antibiotic Stewardship, the Director of Clinical Ethics, the Larner College of Medicine Clerkship Director for the Department of Medicine, the Course Director for Cardiovascular, Respiratory, and Renal Systems in the College of Medicine, the Associate Director for the Department of Medicine Residency Program, and the Director of the Vaccine Testing Center at UVM. We are proud to have become the UVM Health Network Infectious Diseases Division, welcoming ID physicians from Champlain Valley Physicians Hospital and Central Vermont Medical Center. In addition to daily teaching rounds with medical students, residents and fellows, the faculty are actively involved in teaching several courses in the Larner College of Medicine. The ID Division accepts one fellow per year into a two-year fellowship-training program. The graduating fellows have a 100% board certification pass rate. Our fellows have presented abstracts at national ID meetings; published peer reviewed articles, and authored book chapters. We are very pleased that we were able to recruit our graduating fellow this year, Sean Bullis, to join our faculty.

Within our Division, we have several active research laboratories, which support a number of clinical and basic science projects including those performed by a PhD faculty member, graduate and visiting students, laboratory technicians, and often the 2nd year ID Fellow. The Huston laboratory has been continuously funded by the NIH as well as various NGOs and is working on the discovery of therapeutic agents for Cryptosporidium. Investigations of the Kirkpatrick laboratories and Vaccine Testing Center (VTC) continue in the Department of Microbiology and Molecular Genetics (MMG), in tight collaboration with the division of Infectious Diseases. It focuses on improving global health through the assessment of candidate vaccines, microbial diseases, and the understanding of human protective immune responses following vaccination and infection. The team continues to work on development of the NIH’s live attenuated tetravalent dengue vaccine, performs extensive work on dengue human immunology and correlates of protection, Zika vaccine development and immunology, rotavirus immune correlates of protection, polio vaccines and mucosal immunology, as well as human experimental challenge models for Cryptosporidium and dengue. During the last year, collaborative projects with long-standing colleagues in Bangladesh have continued, with some understandable challenges due to COVID. In addition, the VTC was involved with the global efforts at COVID vaccine development, and participated in the national phase 3 study for the Astra Zeneca vaccine candidate. In addition to clinical revenues, financial support is provided by grants from the National Institutes of Health (NIH), especially NIAID, the Health Services Research Administration (HRSA) as well as contracts with regional hospitals, the VT Department of Health, and UVM Medical Center directorships. Obviously, none of this work would be possible without our fantastic support staff. In addition to the 12 attending physicians, the Infectious Diseases Division includes 23 individuals statewide, including 3 midlevel providers, 2 fellows, 2 administrative staff, 5 nurses, 2 medical assistants, 2 schedulers, a dietitian, a social worker, and 5 staff at our HIV outreach hospitals. In addition, there are 3 attending physicians and a midlevel at our Network hospitals. The Division has been recognized with several awards this year, including Dr. Kirkpatrick being named as a 2021–22 University Scholar, Dr. Pierce being awarded the Dean's Faculty Award for Professionalism, Dr. Singh receiving the Gold Humanism Honor Society (GHHS) - Leonard Tow Humanism in Medicine Faculty Award, and Mary Claire Walsh receiving the Dean's Staff Award for Professionalism. . This year saw the much-deserved promotion of Dr. Noyes to Associate Professor. Faculty

W. Kemper Alston, MD, MPH Professor Division Chief, Infectious Disease Division

Attending Physician for Infectious Disease Assistant Hospital Epidemiologist Tuberculosis Consultant, State of Vermont Medical Director, UVMMC Employee Health Infection Prevention Consultant, Northwestern Medical Center HIV care provider, Brattleboro Memorial Hospital, Comprehensive Care Clinic Member, Infection Prevention Committee, UVMMC member, Medical Staff Quality Assessment and Improvement Committee, UVMMC Member, Infectious Diseases Practice Subcommittee, Pharmacy and Therapeutics

Committee, UVMMC Volunteer, Visiting Nurse Association of Chittenden and Grand Isle Counties, Quality

Assurance and Performance Improvement Committee

Jean Dejace, MD Assistant Professor Director, Infectious Disease Fellowship Training Program Attending Physician for Infectious Disease CVPH attending

Andrew Hale, MD Assistant Professor Attending Physician for Infectious Disease Director, Infectious Elective Rotation Course Director, How the Hospital Works, 4th yr medical student course Course Director, Comparative Physiology, Mount Desert Island Biological

Laboratories Course Director, Cardiac Respiratory and Renal Pathophysiology at the UVM

Larner College of Medicine Associate Program Director, Internal Medicine Residency at the UVM Larner

College of Medicine Christopher D. Huston, MD Professor of Medicine with Tenure Research Interests: Intestinal protozoan infections including E. histolytica host-

parasite infections, Cryptosporidium drug development Attending Physician for Infectious Disease Institutional Biosafety Committee, UVM Reappointment, Promotions and Tenure Committee, Department. of Medicine, UVM

College of Medicine

Beth D. Kirkpatrick, MD, FIDSA, FASTMH Professor of Medicine with Tenure Chair, Department of Microbiology and Molecular Genetics Director, UVM Vaccine Testing Center Research Interests: Vaccine development, vaccine immunology, enteric and flavivirus

infections, human experimental infection models. College of Medicine Advisory Committee. UVM Larner College of Medicine. Physician-Scientist Working Group. UVM Larner College of Medicine

Tim Lahey, MD, MMSc Professor of Medicine Director, Clinical Ethics Attending Physician for Infectious Disease Ombudsperson for Graduate Medical Education Co-Chair, Unsafe Patient Behavior Task Force Co-founder, Behavior Response Team Member, Workplace Violence Initiative Member, High Value Care Committee Faculty co-advisor, Social Justice Coalition, UVM Larner College of Medicine Faculty associate-advisor, Albert Schweitzer Fellowship, UVM Larner College of

Medicine Member, Vermont State COVID-19 Serology Workgroup Member, Vermont State Crisis Standards of Care Working Group Member, Vermont COVID-19 Vaccine Implementation Advisory Committee Member, Advanced Integration Level Subcommittee Scholarly interests: clinical ethics, medical education including re social medicine,

tuberculosis vaccines Cindy Noyes, MD Associate Professor of Medicine Attending Physician for Infectious Disease Hospital Epidemiologist Director, Infection Prevention Kristen K. Pierce, MD Professor of Medicine Vice Chair for Academic Affairs Attending Physician for Infectious Disease Lead Clinical Investigator, Vaccine Testing Center Research Interests: Development of Live Attenuated Flavivirus Vaccines Institutional Review Board Louis B. Polish, MD Associate Professor of Medicine Director, Department of Medicine Inpatient Medicine Clerkship Program Attending Physician for Infectious Disease Devika Singh, MD, MPH Assistant Professor of Medicine Director, Part C HRSA Award, Part B HRSA Sub Award, and NEAETC Sub Award Attending Physician for Infectious Disease HIV care provider, Rutland Regional Medical Center, Comprehensive Care Clinic Principal Investigator for Long Term Sequelae of Covid-19 public health surveillance

project between UVMMC and Vermont Department of Health Research Interests: HIV and the sexual and reproductive health of women, sexually

transmitted diseases

Consultant and researcher in pharmacovigilance/safety, Microbicide Trials Network (HIV/AIDS clinical trials network by the National Institute of Allergy and Infectious Diseases)

College of Medicine: Medical Curriculum Committee

Lindsay M. Smith, MD Assistant Professor of Medicine Director, UVMMC Antimicrobial Stewardship Program Attending Physician for Infectious Disease Co-Chair, IDCP sub-committee, Pharmacy and Therapeutics Committee Jose E. Teixeira, PhD Faculty Scientist Interests: Intestinal protozoan infections including E. Histolytica host-parasite

infections, Cryptosporidium drug development Timothy Whitman, DO Associate Professor of Medicine Attending Physician for Infectious Disease HIV care provider, Northeastern Vermont Regional Hospital, Comprehensive Care

Clinic Quality Assurance and Improvement Committee representative

Fellows Sean Bullis, MD Infectious Disease 2nd Year Fellow Infectious Disease Fellowship Training Program July 1, 2019 – June 30, 2021 Katherine Peterson, MD Infectious Disease 1st Year Fellow Infectious Disease Fellowship Training Program July 1, 2020 – June 30, 2022 Nurse Practitioners and Physician Assistants: Jessica Terrien, PsychNP Comprehensive Care clinic, HIV patients HIV Patient Care, mental health Laura Catoe, ARNP Nurse Practitioner, Comprehensive Care clinic Travel health Vermont Refugee Clinic General ID

Mary Claire Walsh, NP Nurse Practitioner, Comprehensive Care Clinic / Vaccine Testing Center General ID Graduate Students, Post-doctoral Fellows, MD PhD Students: Bethany Mihavics—PhD Student (Huston Laboratory) Ethan Mattice—PhD Student (Huston Laboratory) Jubilee Ajiboye – PhD Student (Huston Laboratory) Endowed Professorships: Leadership in Professional Societies: Christopher Huston, M.D.

• Member, American Society for Microbiology Council on Microbial Sciences Beth Kirkpatrick, MD, FIDSA, FASTMH

• Global Health Committee, Infectious Disease Society of America • Institutional Representative, American Society for Clinical Investigation (ASCI) • Scientific Advisory Board. Symposium on Controlled Human Experimental Infection

Models. International Alliance for Biologic Standardization (IABS) Tim Lahey, MD, MMSc

• Member, United States Medical Licensing Examination Microbiology and Immunology Test Material Development Committee

• Member, United States Medical Licensing Examination Step 1 Interdisciplinary Review Committee

• Member, United States Medical Licensing Examination General Principles/Foundational Science Task Force

External Reviewer, Editorships and Editorial Boards: W. Kemper Alston, MD o External reviewer

Annals of Internal Medicine, Clinical Infectious Diseases Infection Control and Hospital Epidemiology

Andrew Hale, MD o External reviewer

• Medical Teacher

• Teaching and Learning in Medicine • BMJ Open • ID Cases: received “Reviewer Recognition” in 2019, 2020 • Contributing writer, Contagion • Journal of Graduate Medical Education • Cancer Causes and Control • Therapeutic Advances in Infectious Disease • PLOS Medicine • Case Reports in Infectious Diseases • Journal of the American Podiatric Medical Association

Christopher Huston, MD o Editorial Board Member – Infection and Immunity o External reviewer

• PLoS Pathogens • PLoS Neglected Tropical Diseases • PLoS ONE • mBio • Antimicrobial Agents and Chemotherapy • Journal of Infectious Diseases • Clinical Infectious Diseases • ACS Infectious Diseases • Cellular Microbiology • Molecular Microbiology • Molecular and Biochemical Parasitology • Journal of Clinical Microbiology • American Journal of Tropical Medicine and Hygiene

Beth Kirkpatrick, MD, FIDSA, FASTMH o Section Editor, American Journal of Tropical Medicine and Hygiene 2014-present o External Reviewer

American Journal Tropical Medicine and Hygiene Clinical Infectious Diseases Journal Infectious Diseases Lancet Infectious Diseases PLOS Neglected Tropical Diseases PLOS Pathogens PLOS ONE Vaccine

Tim Lahey, MD, MMSc o External Reviewer

Clinical Infectious Diseases Academic Medicine The Lancet Respiratory Medicine AMA Journal of Ethics

Kristen Pierce, MD o External reviewer

• American Society of Tropical Medicine and Hygiene Study Sections and Federal Advisory Boards: Christopher Huston, MD o Ad-Hoc Reviewer - National Institutes of Allergy and Infectious diseases

o 2020, PTHE study section (Pathogenic Eukaryotes)

Beth Kirkpatrick, MD, FIDSA, FASTMH o Indo-US Vaccine Action Program, Candidate Vaccine Advisory Committee (CVAC). -

international Vaccine Working Group

Kristen Pierce, MD o ACIP American Council on Immunization Practices – CDC working group on Flavivirus

Vaccines o Indo-US Vaccine Action Program, Candidate Vaccine Advisory Committee (CVAC). –

international Vaccine Working Group

Major Faculty Awards: Andrew Hale, MD UVMMC Foundations Course Director Award Tim Lahey, MD, MMSc Albert Schweitzer Fellowship Leadership Award 2019 Cindy Noyes, MD University of Vermont Medical Center Department of Medicine, Distinguished Clinician Award Devika Singh, MD Innovation Grant through the UVM Health Network Medical Group. Title of the project: Sexual and Reproductive Health Needs and Experiences of Women Living with HIV/ AIDS in Vermont. The award is for a two year project starting January 2021 through December 2022 Grants – list all active by faculty member, PI Andrew Hale, MD Frymoyer Scholars Program 7/1/18-6/30/20 Optimizing Care for Vermonters Infected with Hepatitis C Virus through a Statewide Educational Curriculum

$50,000 Andrew Hale, MD (PI) HIV/HCV Care for Incarcerated Persons in Vermont Consultant for the State of Vermont Department of Corrections contractor for optimizing care of HIV and HCV infected persons who are incarcerated in Vermont. 3/1/2019-2/28/2020 $48,000 per year Andrew Hale, MD (PI) Eureka Grant, University of Vermont Department of Medicine. The Impact of Infectious Diseases Provider Involvement on Asplenic Care Outcomes 4/11/2019-6/30/2022 $10,000 Chris Huston (Co-investigator (5%)) (Jason Botten is the PI) NASA Jet Propulsion Laboratory Title: Screening of novel anti-SARS-CoV-2 peptides for infection of Vero E6 cells with SARS-CoV-2 June 1, 2020-December 31, 2020 Direct costs: $100,000 Christopher Huston (Co-investigator) (Melissa Love (PI) at Calibr at Scripps Institute) Wellcome Trust Title: New treatments for cryptosporidiosis Role: Principal Investigator of sub-contract at UVM (1% effort) 11/1/2020-10/31/2023 UVM total costs: $15,000 Christopher Huston, MD (PI) Merck Serono Project title: Screening the Merck “mini-library” for anti-Cryptosporidium drug activity Role: Principal investigator (2.6% effort) 12/1/2015-12/31/2019 Direct costs: $ 43,547 Total costs: $ 67,032 Christopher Huston, MD (PI) National Institute of Allergy and Infectious Diseases R21 AI130807 Project title: Continuous in vitro culture and treatment of Cryptosporidium using small molecule differentiation inhibitors Role: Principal investigator (10% effort) 1/25/2017-12/31/2019 (NCE) Direct costs: $275,000 Total costs: $ 419,375 R01 AI143951 Christopher Huston, MD (PI) National Institutes of Allergy and Infectious Diseases (NIAID) Project title: Preclinical optimization of a parasiticidal drug for cryptosporidiosis

The goal of this project is to develop a new drug candidate for treating cryptosporidiosis and determine its molecular mechanism of action, beginning with a piperazine-based lead compound identified through phenotypic screening. Role: Principle investigator (multi-PI grant; Huston lead (20% effort)) 3/01/2019-02/29/2024 UVM Direct costs: $1,088,495 UVM Total costs: $1,682,577 R21 AI141184 Christopher Huston, MD (PI) National Institutes of Allergy and Infectious Diseases (NIAID) Project title: Repurposing the EMD-Serono “mini-library” for Cryptosporidium drug development. The goal of this project is to develop a new drug candidate for treating cryptosporidiosis, using high-value EMD-Serono compounds as the chemical starting points. Role: Principle investigator (multi-PI grant; Huston lead (10% effort)) 2/01/2019-1/30/2021 UVM Direct costs: $297,992 UVM Total costs: $456,623 R33 AI141184 Christopher Huston, MD (PI) National Institute of Allergy and Infectious Diseases (NIAID) Project Title: Repurposing the EMD-Serono “mini library” for Cryptosporidium drug development. The grant is a continuation of the R21 grant listed above Role: Principle investigator (multi-PI grant; Huston lead (10% effort)) 1/31/2021-1/31/2024 UVM Direct Costs $1,246,99 UVM Total Costs $1, 373,205 Christopher Huston MD (Co-PI) (10% effort) Gilbert (PI) (University of Dundee) Medical Research Council (Great Britain) Project title: Development of new agents for the treatment of cryptosporidiosis Role: Principal investigator of sub-project at UVM (10% effort) 1/2019-8/2021 UVM Direct costs: $330,884 UVM Total costs: $330,884 P20GM125498 Kirkpatrick (PI) National Institutes of General Medical Sciences Center of Biological Research Excellence (COBRE) Project title: Translational Research to Prevent and Control Global Infectious Diseases (Translational Global Infectious Diseases Research Center, TGIR) The goal of this project is to establish a center for translational infectious diseases research at UVM by facilitating interactions between faculty in the biological sciences with faculty in the engineering and data sciences. Role: Co-principal Investigator (20% effort) 10/01/18-09/30/23 UVM Direct costs: $7,515,013 UVM Total costs: $11,515,478 NIH U01 AI141997 Kirkpatrick, Diehl, Botten (MPI)

Mechanisms of Protection and Durability for a Live, Attenuated Tetravalent Dengue Vaccine This work seeks to clarify the immune components and mechanisms of durable protection of a live tetravalent dengue vaccine.

02/2019-01/2024 Bill & Melinda Gates Foundation (Kirkpatrick (PI) New Paradigms of Campylobacter Persistence and Transmission in Zimbabwean Infants. This work follows our observations of human Campylobacter recrudescence and uses metagenomic sequencing in a new birth cohort to re-examine reservoirs and transmission of this important pathogen. This data may improve prevention of an important cause of infant diarrhea and poor health in low-income settings. 1/2019-12/2022 NIH P20 GM125498-01 Kirkpatrick (PI) 10/2018-9/2023 Center of Biomedical Research Excellence (COBRE) award for the Translational Global Infectious Disease Research (TGIR) Center. This award supports institution-wide growth in global Infectious Disease research and the support and development of junior faculty (from both biomedical and computational/quantitative data fields) toward research independence. 10/2018-9/2023 Beth D. Kirkpatrick, MD Principal Investigator Improving Rotavirus Vaccination: Refining Correlates of Protection and Immunologic Responses to Vaccination. The major goals of this project are to permit better understanding and use of immunologic markers (correlates) of protection and identify the optimal immunologic responses and variables inhibiting responsiveness to rotavirus vaccination. $2,200,000 (2015-2019) Bill and Melinda Gates Foundation Beth D. Kirkpatrick, MD Site Principal Investigator Operation of a Facility for the Study of Infectious Agents, Vaccines, and Antimicrobials in Adult and Pediatric Human Subjects. This award supports the design and implementation of a series of large outpatient clinical studies and basic immunology evaluations of novel live flavivirus (e.g. Dengue, West Nile, Zika) virus vaccines and human challenge models. $9,000,000 (2009-2019) National Institutes of Health and Johns Hopkins University Devika Singh, MD MPH (Principal Investigator) UVM Medical Group / Vermont Department of Health Sexual/Reproductive Health Needs and experiences of women 1/1/2021 – 12/31/2022 $50,000 non Federal award VDH Devika Singh, MD New England AIDS Education Training 7/1/2020 – 6/30/2021 $49,039 Federal sub-award, UMASS

Devika Singh, MD (PI) Ryan White Part C Grant for HIV Care 5/1/2020– 4/30/2021 $ 530,005 Federal HRSA Devika Singh, MD (PI) Ryan White Part C Grant for HIV Care 5/1/2021 – 4/30/2022 $ 530,005 Federal HRSA Devika Singh, MD (PI) Ryan White HIV/AIDS Program Part C EIS Covid-19 Response 4/1/2020 – 3/31/2021 $ 77,125 Federal HRSA Devika Singh, MD (PI) Ryan White Care Act Part B Sub Award 1/1/2020– 12/31/2020 $340,000 Federal HRSA Devika Singh, MD (PI) Ryan White Care Act Part B Sub Award 1/1/2021– 12/31/2021 $290,000 Federal HRSA Lindsay M. Smith, MD Vermont Department of Health Antimicrobial Stewardship Grant 6/1/17 – 4/30/20 Total Direct Costs $410,939 Publications – peer reviewed, chapters, etc. (not abstracts) Whitman TJ, Noyes CD, Hale AJ, Singh D, DeVoe SG, Repp AB, Pierce KK, Polish LB, Kirkpatrick BD, Dejace J, Smith LM, Lahey T, Huston CD, Catoe LJ, Ghatage P, Bullis S, Alston WK. Impact and costs of a hepatitis C virus screening programme for adults hospitalised at an academic medical centre. BMJ Open Quality 2021;10:e001248. doi: 10.1136/bmjoq-2020-001248 Ahern JW, Noyes CD, Smith LM, Alston WK. Twenty years of infection prevention: A longitudinal perspective from an academic medical center. Infection Control and Hospital Epidemiology 2021; in press. Hale A, Ricotta D, Freed J, Smith CC, Huang G. Comparing Two Adapted Maslow’s Hierachy of Needs Frameworks on Physician Wellness. American Journal of Medicine. 2020;133(9):E532-E533. PMID 32867946. doi.org/10.1016/j.amjmed.2020.02.030

Bullis S, Crothers J, Wayne S, Hale A. A Cautionary Tale of False-Negative Covid-19 Testing. IDCases, May 5, 2020: e00791. PMID 32377507. doi.org/10.1016/j.idcr.2020.e00791 Lam BD, Hale A, Bullis SS, He YT, Khan S, Freed JA. A Retrospective Review of 193 Cases of Severe Eosinophilia in the Northeast United States. American Journal of Medicine, 2020;S0002-9343(20)31123-2. PMID 33359774. doi: 10.1016/j.amjmed.2020.11.022 Hale A. A Tale of Two Doctors. Journal of Medical Education and Training, 2021; 5:e055

Hale A, Ricotta DN, Freed J. Important Consults are Not Always “Perfect”. Academic Medicine. 2021; 96(3):320-1. PMID 33661842. doi: 10.1097/ACM.0000000000003871

Bougiouskas L, Psoinos R, Jones D, Morris E, Hale A. Disseminated Herpes Simplex Virus 2 as a Complication of Pregnancy. IDCases, 2021; 24:e01107. PMID 33889496. doi: 10.1016/j.idcr.2021.e01107 He Y, Peterson K, Crothers J, Dejace J, Hale A. Endocarditis and Systemic Embolization from Whipple’s Disease. IDCases, 2021; 24:e01105. PMID 33868927. doi: 10.1016/j.idcr.2021.e01105

Hale T, Petherick A, Phillips T, Sridhar S, Thompson R, Webster S, Hale A. Government responses and COVID-19 deaths: global evidence across multiple pandemic waves. PLOS One, 2021; 16(7):e0253116. PMID 34242239. doi 10.1371/journal.pone.0253116 Ricotta D, Hale A, Freed J, Zeidel M, Herzig S. Generalists as Clinical Physiologists: Bringing science back to the bedside. Journal of General Internal Medicine, 2021. PMID 34240283. Doi: 10.1007/s11606-021-06978-0 Hasan M, Teixeira JE, Lam YW, Huston CD. Coactosin phosphorylation controls Entamoeba histolytica cell membrane protrusions and cell motility. mBio. 2020. 4: e00660-20. 10.1128/mbio.00660-20. PMID: 32753489. Bruce EA, Tighe S, Hoffman JJ, Laaguiby P, Gerrard DL, Diehl SA, Leonard DGB, Huston CD, Kirkpatrick BD, Crothers JW, Dragon J, Botten J. Direct RT-qPCR detection of SARS-CoV-2 RNA from patient nasopharyngeal swabs without an RNA extraction step. PLoS Biology. 2020. Oct 2;18(10):e3000896. doi: 10.1371/journal.pbio.3000896. PMID: 33006983. Vinayak S, Jumani RS, Miller P, Hasan MM, McLeod BI, Tandel J, Stebbins EE, Teixeira JE, Borrel J, Gonse A, Zhang M, Yu X, Wernimont A, Walpole C, Eckley S, Love MS, McNamara CW, Sharma M, Sharma A, Scherer CA, Kato N, Schreiber SL, Melillo B, Striepen B*, Huston CD*, Comer E*. Bicyclic azetidines kill the diarrheal pathogen Cryptosporidium in mice by inhibiting parasite phenylalanyl-tRNA synthetase. Science

Translational Medicine. 2020. 12 (eaba8412): 1-13. PMID: 32998973. *indicates co-corresponding authors. Hasan MM, Stebbins E, Choy RKM, Gillespie JR, de Hostos EL, Miller P, Mushtaq A, Ranade RM, Teixeira JE, Verlinde CLMJ, Sateriale A, Zhang Z, Osbourn DM, Griggs DW, Fan E, Buckner F*, Huston CD*. Spontaneous selection of Cryptosporidium drug resistance in a calf model of infection. Antimicrobial Agents and Chemotherapy. 2021. Mar 22:AAC.00023-21. doi: 10.1128/AAC.00023-21. Online ahead of print. PMID: 33753338 *co-corresponding authors Ghatage P, Pierce KK, Wojewoda C, Mendelson N, Wilcock J, Nesbit R, Huston CD, Whitman TJ. A veterinarian from Vermont presenting with a painful right index finger following a needlestick injury that occurred while caring for a dog. Clinical Infectious Diseases. 2020. 71:1577-1579. PMID: 32918550. Huston CD. Editorial commentary: The CRYPTOFAZ trial and lessons learned for anticryptosporidial drug development. Clinical Infectious Diseases. 2020. Apr 11. pii: ciaa425. doi: 10.1093/cid/ciaa425. PMID: 32277815. Choy R, Huston CD. Editorial commentary. Cryptosporodiosis should be designated as a tropical disease by the US Food and Drug Administration. PLoS Neglected Tropical Diseases. 2020. Jul 2;14(7):e0008252. doi: 10.1371/journal.pntd.0008252. PMID: 32614819. Lahey T. “The Bottom of the Health Care Rationing Iceberg” New England Journal of Medicine December 3, 2020; 383:2200-2201. doi: 10.1056/NEJMp2021953. Epub 2020 Nov 28. PMID: 33252205 Lahey T, Herbst J. “A Small-Town Heart: Should Clinicians Suspect a Rural Mother of Neglect” Hastings Center Reports 2020 Nov;50(6):4-7. doi: 10.1002/hast.1192. PMID: 33315248 Goyal RK, Dawson CA, Epstein SB, Brach RJ, Finnie SM, Lounsbury KM, Lahey T, Eldakar-Hein ST. “The Design and Implementation of a Longitudinal Social Medicine Curriculum at the University of Vermont’s Larner College of Medicine” BMC Medical Education 2021 Feb 24;21(1):131. doi: 10.1186/s12909-021-02533-x. Stein CM*, Benchek P*, Bartlett J, Igo RP, Sobota RS, Chervenak K, Mayanja-Kizza H, von Reyn CF, Lahey T, Bush WS, Boom WH, Scott WK, Marsit C, Sirugo G, Williams SM. “Methylome-wide analysis reveals epigenetic marks associated with resistance to tuberculosis in HIV-infected individuals from East Africa,” Journal of Infectious Diseases 2021 Jan 5;jiaa785. doi: 10.1093/infdis/jiaa785. Online ahead of print. Lahey T. “How Should Clinicians Respond if Patient HIV Denial Could Exacerbate Racial Health Inequities?” AMA Journal of Ethics 2021 May 1;23(5):E382-387. doi: 10.1001/amajethics.2021.382. https://edhub.ama-assn.org/ama-journal-of-ethics/module/2779244

Lahey T, Reeves S, Desjardins I, Nelson W. “Organizational Ethics Support for Health Care Leaders during the COVID-19 Pandemic and Beyond” Journal of Hospital Ethics 2021:7(2):58.. Gau J, Nwora C, Eldakar-Hein S, Sanghavi M, Lahey T, Repp AB. “Things We Do for No Reason: Routine Inclusion of Race in the History of Present Illness” Journal of Hospital Medicine 2021 (in press) Carey M, Stedman N, Giglio C, Bruzzese C, Eldakar-Hein S, Lahey T. “Ethical Hospital Discharge: A Balanced Algorithmic Approach.” Journal of Hospital Ethics 2021 (in press). Ades S, Herrera DA, Lahey T, Thomas A, Jasra S, Barry M, Sprague J, Dittus K, Plante T, Kelly J: Kaufman P, Parsons P, Holmes C. “Cancer Care in the Wake of a Cyberattack: How to Prepare and What to Expect” JCO Oncology Practice 2021 (in press). Brach RJ, Finnie SM, Goyal RK, Dawson CA, Epstein SB, Lounsbury KM, Eldakar-Hein ST, Lahey T. “A New Roadmap for Social Medicine Curriculum Design Based on Mixed Methods Student and Faculty Curriculum Evaluations.” BMC Medical Education 2021 (in press).

European Haplotype of Echinococcus mulitlocularis Identified in the United States: An Emerging Disease? Polish, Louis, Pritt, Bobbie, Barth, Thomas F E, Gottstein, Bruno, O’Connell Elise M. Clinical Infectious Disease. 2021 April 72(7).

Dr. Kristen Pierce – mentioned/quoted in UVM COM news: A Matter of Trust: Bringing Vaccine Education to New American Communities. http://med.uvm.edu/com/news/2021/02/24/a_matter_of_trust_bringing_vaccine_education_to_new_american_communities

Singh D, Switzer WM, Belcher R, Daltry D, Read JS. Identification of an HIV-1 and Neurosyphilis Cluster in Vermont. Clin Infect Dis. 2020 Dec 8:ciaa1834. doi: 10.1093/cid/ciaa1834. Epub ahead of print. PMID: 33289032.

DIVISION OF NEPHROLOGY Annual Report – July 1, 2020-June 30, 2021

A. Executive Summary:

The past year continued to be a challenging one for the Division. We saw a continued reduction in available FTE, and a complete shut down of office based visits. We did rehire Megan Houstan to staff the Acute Dialysis Unit, a major source of patient and staff satisfaction. We continued patient care activities largely through ‘virtual’ visits. We learned that these were more efficient than office visits and as a result our arrived visits increased nearly 40% with almost every provider exceeding their budgeted targets (the exceptions were in those who were on maternity leave during this time period). In the Spring of 2021, we reopened office visits but continue to have 85-90% of patient visits via telephone or zoom. The Division started an ACO funded ‘navigator’ program to work specifically with patients who are nearing end stage renal disease. The recently hired navigator will be interacting with these patients, educating them with regard to diet, dialysis, transplantation, and palliative care options, establishing ‘goals of care’ documents, and facilitating the transition to a path consistent with those patient goals. The ultimate goal is to improve the patient experience and reduce hospitalizations and costs associated with developing end stage kidney disease. There are currently ~100 patients enrolled in the program and we are accumulating statistics on patient satisfaction, timeliness of dialysis starts, referrals to transplant program, referrals to home dialysis program, etc. Research activities increased in the past year. Dr. Kat Cheung was successful with a number of competitive grants including the COBRA grant on neural and brain microcirculatory health and was a subPI for an NIH grant involving training of dialysis providers to effectively discuss end of life issues with patients using a ‘best case-worse case scenario’ format. Dr. Solomon oversaw a pilot trial of low frequency ultrasound to protect the kidneys from insult during TAVR procedures. The trial monitored renal production of nitric oxide and urinary oxygen levels. Positive results were observed and a manuscript has been submitted. A national trial (Dr. Solomon as National PI) is just getting started using the same technology in patients undergoing cardiac angiography. A number of pharmaceutical sponsored trials in IgAl nephropathy, diabetes, glomerular diseases were also started in the past year while we completed trials in diabetes, IgA and metabolic acidosis. We lost one research coordinator and are currently posting the position for a replacement. On the educational front, we remained without a renal fellowship program. Dr. Onuigbo has agreed to become the program director with help from Drs. Fitzgerald and Narasimhadevara. During Covid, we stopped accepting observers into the Division. This had been a consistent source of learners for the Division. One of our early 2020 observers successfully interviewed at UVMMC and is now a first year resident here.

Despite the many challenges associated with the loss of clinical FTE (higher workload, more nights and weekends on call), EMR upgrades, financial constraints on variable compensation, loss of childcare services affecting some of our junior faculty, the Division scored extremely well on provider satisfaction and was one of the lowest on the burnout survey. None of the above changes have diminished patient access and the quality of care delivered. Indeed, the Division was a leader in the Press-Gainey patient satisfaction survey. At the Network level, very little has changed over the past year. CVPH and the Plattsburgh community are underserved with regard to outpatient CKD visits despite the presence of two UVM trained nephrologists who do not have resources for outpatient care. Patient Care RVU target FY19 – 32,210 Actual 30,066 (-6.7%) RVU target FY20 – 36,652 Actual 18,586 (-23.5%) as of May 2020 Arrived Visits target FY19 -6440 Actual 4305 (-33%) Arrived Visits target FY20 -6674 Actual 3196 (-27.8%) as of May 2020

B. Faculty Varun Agrawal, MD Associate Professor Medical Director of Barre Dialysis Unit Education of medical residents, burnout in nephrology fellows Katherine Cheung, MD Assistant Professor of Medicine Frailty in chronic kidney disease, cognitive decline in end stage kidney disease

Chidinma Enyinna, MD Assistant Professor of Medicine Coverage of Rutland dialysis unit Interest in quality improvement projects (Dr. Onuigbo mentor) Alison Fitzgerald, MD Assistant Professor of Medicine Medical Director Newport Dialysis Unit Well-being of medical students Virginia Hood, MD Professor of Medicine Director of Stone Clinic

High value care, nephrolithiasis

Abhishek Kumar, MD Assistant Professor of Medicine

Transplant, including cardiac transplant

Nina Narasimhadevara, MD Assistant Professor of Medicine Medical Director, Rutland Dialysis Unit Urinary oxygen as marker of kidney function Macaulay Onuigbo, MD Professor of Medicine Medical Director of Home Dialysis Unit Acute kidney injury Marios Prikis, MD Associate Professor of Medicine Medical Director of Transplantation Transplantation Jeff Rimmer, MD Professor of Medicine Medical Director Acute In-Patient Dialysis Unit and Chittenden County Dialysis Unit Hemodialysis,

Richard Solomon, MD Professor of Medicine Director, Division of Nephrology Medical Director of Acute Dialysis Unit Acute kidney injury Sree Susarla, MD Assistant Professor of Medicine

Wolfgang Weise, MD Associate Professor of Medicine Medical Director, St. Albans Dialysis Unit Glomerulonephritis

C. Fellows:

None

D. PA/NP:

Margaret Butler, APRN (outpatient hemodialysis and chronic kidney disease) She is our designated ‘superuser’ for EPIC Megan Houston, APRN (in patient hemodialysis)

E. Post-doctoral Fellows (Ph.D.)

None

F. Endowed Professorship Patrick Professorship (Dr. Solomon)

G1. Leadership in Professional Societies

o Kidney Disease Outcome Quality Initiative Education committee, National Kidney Foundation (Agrawal)

o American Academy of Hospice and Palliative Medicine special interest group (Cheung)

o American Geriatrics Society Junior Faculty Committee (Cheung) o Member, Kidney Supportive Care Work Group (Cheung) o Member, UVM Medical Center Board of Trustees, 2014-present (Hood)

Chair, UVM Health Network Population and Quality Committee, 2017-present (Hood) Member, UVM Health Network Board of Trustees, 2017 –present (Hood)

o Member Executive Committee, International Society Internal Medicine 2015-present (Hood)

o Member, Sydney University Graduate Union North America Board of Trustees (Hood)

o Member, ACP Membership Committee (Hood) o Member, ACP Vermont Chapter Council (Hood) o President Emeritus, American College of Physicians (Hood) o Member of the European Board of Transplant Medicine, National representative

(Prikis) Board Member and Examiner for the Transplant Medicine certification of the European Union of Medical Specialties (UEMS). (Prikis)

o European network for Collaboration on Kidney Exchange Program – COST action (Prikis)

o Chairman, Constitution and Bylaws Committee, Association of Nierian Physicians in the Americas (Onuigbo)

o ESRD Network 1 Board of Directors (Rimmer) ESRD Network 1 Medical Review Committee (Rimmer)

G2: Larner College of Medicine, Department of Medicine

o Teaching Academy-Portfolio Review Committee, LCOM (Agrawal) o UVM Center for Aging, Executive Council (Cheung) o Department of Medicine Faculty Engagement and Communication Committee

(Cheung) o Department of Medicine, Resident Research Committee (Cheung) o Chair, Practitioner Health Advocacy Committee (PHAC), LCOM (Fitzgerald) o Member, Medical Student Wellness Committee, LCOM (Fitzgerald) o Member, Professionalism, Communication and Reflection Committee, LCOM

(Fitzgerald) o Member, Diversity of Inclusion, Department of Medicine, LCOM (Onuigbo) o Member, Larner College of Medicine Gender Equity Steering Committee

(Onuigbo) o Member, The Robert Larner, M.D. College of Medicine Teaching Academy

Educational Scholar Mentoring Group (Onuigbo) o Department of Medicine, Quality Assurance and Improvement Committee

(Onuigbo) o University of Vermont Medical Center, Pharmacy and Therapeutics Committee

(Onuigbo) o University of Vermont Medical Center, Medical Records Committee (Onuigbo) o Department of Medicine, Faculty Development Committee (Prikis) o Department of Medicine, Quality Improvement Committee (Rimmer) o Department of Medicine, Operations Committee, (Kumar) o Epic Dialysis Module “Power Team” (Rimmer)

H. Editorships and Editorial Boards

o Associate Editor, Journal of Medical Case Reports. Nov 2014 to present (V.Agrawal)

o Associate Editor, BioMed Central Nephrology. Nov 2016 to present (V. Agrawal) o Member, Editorial Board, International Journal of Clinical Practice (Onuigbo) o Member, Editorial Board, BioMed Research International (Onuigbo) o Member, Editorial Board, Journal of Renal Injury Prevention (Onuigbo)

I. Study Section and Federal Advisory Boards

J. Major Faculty Awards o Cheung. KL. Junior Faculty Researcher of the Year, UVM Health Network 2020.

K. Grants (all grant accounts show a positive balance) – active 2020-2021 Federal

o National Palliative Care Research Center Career development award ($154,000 over 2 years) – (Cheung) July 2018- Dec 2020) Telemedicine facilitated palliative care consultations in rural dialysis units– (Cheung)

o NIH-NIA R01 (June 2020-Feb 2025- $202,800) A Randomized-Clinical Trial of a

Communication Tool to Improve Access to Palliative Care for Patients with End-Stage Renal Disease (Cheung- site PI)

o NIH RO1 DK113201 IMPROVE AKI: A Cluster-Randomized Trial of Team-Based

Coaching Interventions to IMPROVE Acute Kidney Injury (Jeremiah Brown, PI) Role: Sub PI July 2018-June 2023 (Solomon)

o NIH-

NIGMS o Cushman/Nelson (PI) o 8/2020-7/2023

Trajectories and vascular mechanisms of cognitive impairment in chronic kidney disease The goal of this study is to examine the trajectories of cognitive impairment in chronic kidney disease in the REGARDS study, to identify risk factors for rapid decline and to examine potential vascular mechanisms of cognitive impairment in CKD. Role: o Cheung, Project Director o Direct Costs:

o $495,000 o

University of Vermont

o Aortic pathology and acute kidney injury in patients undergoing TAVR (Solomon/Dauerman) IRB 17-0238

o University of Vermont Center for Biomedical Innovation (UVM CBI) SEED Project Research Award, 2021-2022. (Onuigbo) Hemodialysis Filter Rotator/Manipulator. March 9, 2021. This is a two-term Electrical and Biomedical Engineering/Mechanical Engineering Capstone Design UVM Course. University of Vermont (UVM) College of Engineering and Mathematical Sciences (CEMS) Senior Experience in Engineering Design (SEED) UVM CEMS – SEED.

o UVMMG (MG191 - $50,000 ): A pilot crossover study of the impact of increased urine flow rate by oral hydration versus bolus intravenous furosemide infusion on urinary oxygen tension. (Narasimhadevara, Onuigbo, Solomon)

Multicenter Pharmaceutical grants

o Bayer Figaro and Fidelio Trials: Use of finerenone for patient with diabetes and

chronic kidney disease (Solomon) IRB: 16-057 and 16-058 o REATA: Study of bardoxylone treatment in patients with autosomal dominant

polycystic kidney disease (Solomon) IRB: Study 341 o CALLIDITAS: Budesonide therapy in patients with IgA nephropathy (Solomon) IRB

Study 15 o TRC101: Treatment of metabolic acidosis in patients with chronic kidney disease

using a novel H+ binder (Solomon) IRB 19-0188 o APOLLO study: participating center (Prikis) o Cell free donor DNA (Allosure) in diagnosing BK nephropathy. Study run by Univ of

Rhode island and CareDx- Pending budget approval, participating center (Prikis) L. Publications

1. Dae,MW, Liu,KD, Solomon,RJ, Gao,DW, Stillson,CA. Effect of low frequency therapeutic ultrasound (LOTUS) on induction of nitric oxide in chronic kidney disease – Potential to prevent acute kidney injury. (accepted) Kidney Diseases, 2020,

2. Solomon, R. Forced diuresis using intravascular volume devices. Kidney Disease in the Cardiac Catheterization Laboratory: A practical approach. Ed. Rangaswami, Lerma, McCullough, Springer 2020

3. Solomon, R. Contrast-Associated acute kidney injury. Renal Disease and Coronary, Peripheral and Structural Interventions, Ed. Price, Gurm, Elsevier, 2020.

4. Cheung, KL, Tamura, MK, Stapleton, RD, Rabinowitz, T, LaMantia, MA, Gramling, RJ. Feasibility and acceptability of telemedicine-faciliated palliative care consultations in rurul dialysis units. Palliat Med, 2021. PMID 33470899..

5. Carver, JA, Cheung, KL Feasibility and acceptability of yogic breathing/mindfulness meditation e-intervention on sumptoms and VOVID-19-associated anxiety in patients receiving dialysis. J Palliat Med.2021; 24:1124-1126. PMID 34152865.

6. Palmer BF, Carrero JJ, Clegg DJ, Colbert GB, Emmett M, Fishbane S, Hain DJ, Lerma E, Onuigbo M, Rastogi A, Roger SD, Spinowitz BS, Weir MR. Clinical Management of Hyperkalemia. Mayo Clin Proc. 2021 Mar;96(3):744-762. doi: 10.1016/j.mayocp.2020.06.014. Epub 2020 Nov 5. PMID: 33160639.

7. Locke A, Bushey MA, LaCroix C, Deardoff P, Chukwukadibia ,Onuigbo MA. Timed Controlled Repeated Rotation of the CAR-170-C NXSTAGE Chronic Cartridge Hemodialysis Filter: A Novel Approach to Enabling Heparin-Free Frequent Daily Home

Hemodialysis. Mayo Clin Proc Innov Qual Outcomes. 2020 Nov 6;5(1):219-224. doi: 10.1016/j.mayocpiqo.2020.08.003. PMID: 33718796; PMCID: PMC7930779.

8. Onuigbo MA, Tan H, Sherman SE. Alternating Episodes of True Hyperkalaemia and Pseudohyperkalaemia in Adult Sickle Cell Disease: A Nephrologist's Dilemma. EMJ Nephrol. 2021;9[1]:55-57. Abstract Review No. AR6.

9. Onuigbo MA, Olabode K, Sengodan M. ‘Sweet Hypoxia’ with Acute Kidney Injury: The Unpredictability of Acute Hypoxic Respiratory Failure in COVID-19 Infection – a Community Hospital Experience. EMJ Nephrol. 2021;9[1]:48-49. Abstract Review No: AR2.

10. Onuigbo MA, Tan H, Sherman SE. Alternating and Concurrent True Hyperkalemia and Pseudohyperkalemia in Adult Sickle Cell Disease. Rambam Maimonides Med J 2021;12 (2):e0018. doi:10.5041/RMMJ.10439

11. Onuigbo MAC. Stopping RAS Inhibitors in Advanced Chronic Kidney Disease and Cardiorenal Outcomes-Several Unanswered Questions Remain. Am J Med. 2021 Aug;134(8):943. doi: 10.1016/j.amjmed.2021.03.031. Epub 2021 May 4. PMID: 33961836.

12. Onuigbo, M.A.C. Postoperative Acute Kidney Injury in Abdominal Operations: a Critical Appraisal. Indian J Surg (2021). https://doi.org/10.1007/s12262-021-03031-6.

Abstracts; 1. Macaulay Onuigbo, Kolade Olabode, Mohan Sengodan, MO170. “SWEET HYPOXIA”

WITH ACUTE KIDNEY INJURY: THE UNPREDICTABILITY OF ACUTE HYPOXIC RESPIRATORY FAILURE IN COVID-19 INFECTION - A COMMUNITY HOSPITAL EXPERIENCE, Nephrology Dialysis Transplantation, Volume 36, Issue Supplement_1, May 2021, gfab092.0048, https://doi.org/10.1093/ndt/gfab092.0048

2. Macaulay Onuigbo, Sarah Sherman, Heng Tan, MO218. ALTERNATING EPISODES OF TRUE HYPERKALEMIA AND PSEUDOHYPERKALEMIA IN ADULT SICKLE CELL DISEASE - A NEPHROLOGIST'S DILEMA, Nephrology Dialysis Transplantation, Volume 36, Issue Supplement_1, May 2021, gfab092.0096, https://doi.org/10.1093/ndt/gfab092.0096

INVITED SPEAKER National and International: AAHPM- oral presentation at Annual Assembly for the American Academy of Hospice and Palliative Medicine 2021 Virtual Meeting Sanchez-Reilly Sandra E, Cheung KL, Shea Kimberly, Vasquez Anjuli. Breaking Access and Distance Barriers: Using Innovative Modalities of Tele-palliative Care. [Abstract and Oral presentation] American academy of hospice and palliative medicine. Thursday 2/18/2021. ASN- two poster presentations at Kidney Week 2020

1. Cheung KL, Cushman Mary, Crews Deidra C, Judd Suzanne E, Warnock David G, Gutierrez Orlando M. Incidence of and Risk Factor for Incident eGFR<60 in the REasons for Geographic and Racial Differences in Stroke Study. [Abstract]. J Am Soc Nephrol 31: 2020.

2. Cheung KL, Kurella Tamura M, LaManta MA, Rabinowitz T, Stapleton R, Gramling R. Feasilibity and Acceptability of Telepalliative Care in Rural Dialysis Units. [Abstract]. J Am Soc Nephrol 31: 2020.

American College of Physicians, Vermont Chapter: 2020 Tsai, M, Agrawal, V, Foerg, F. Anaplasma Kidney Injury: a case report of renal failure in the setting of subacute anaplasma infection.

Hood. Family Medicine Annual Review Course, Burlington, VT Oct 2020. Hypertension.

Hood. American College of Physicians Webnar. Transitioning from work to retirement: barriers and strategies for advanced career physicians. Jan 2021.

Hood: NCHC Quarterly Provider Meeting. Hypertension. Diagnosis and Treatment Goals in 2021: Sifting through the controversy. June 2021.

Solomon. Family Medicine Department Grand Rounds. Management of chronic kidney disease Oct 2020

Division of Pulmonary and Critical Care Medicine

Anne Dixon MA, BM BCh, Director

http://www.med.uvm.edu/medicine/pulmonary

The Pulmonary Critical Care Division, like other divisions, continued to face tremendous challenges this year related to COVID. Members of the Division continued to lead local and national efforts to address the pandemic, and at the same time have won a number of major local and national awards, and had an outstanding productive year. This has been a very successful year for the Division.

The Division manages critically ill patients in the Medical Intensive Care Unit, provides inpatient pulmonary and critical care consults, and has a number of sub-specialty clinics including those in interstitial lung disease, cystic fibrosis, lung cancer, cancer survivorship, pulmonary hypertension, and asthma. The Division provides a full range of pulmonary diagnostic services: these include bronchoscopy, pulmonary function testing, evaluation of sleep disorders, lung cancer screening and evaluation, an interventional pulmonary program, and a nationally certified pulmonary rehabilitation program.

Members of the Division continued to be very productive academically. In fact this year, the faculty published approximately 140 peer-reviewed articles and book chapters. Members of the faculty also obtained very significant funding from a number of foundations and major grants from the National Institutes of Health. This publication and funding record are particularly impressive given the competing demands on faculty time during the last year.

Members of the Division continue to have major national leadership roles: Dr. Gil Allen serves on the Society of Critical Care Medicine Congress Planning Committee; Dr. Carney serves as a member of the American College of Physicians Board of Regents; Dr. Dixon Chairs the American Lung Association Scientific Advisory Committee and serves on the Board of Directors; Dr. Matt Kinsey serves on the Board of Directors of the American Association of Bronchology and Interventional Pulmonology; Dr. Stapleton served as the Chair of the Critical Care Assembly of

the American Thoracic Society and on the Board of Directors; and, Dr. Weiss serves as the Chief Scientific Officer for the International Society of Cell and Gene Therapies and on the Board of Directors for the same organization. Members of the Division serve on numerous national grant review committees, and editorial boards for major publications.

Members of the Division have received a number of very prestigious awards. Dr. Jason Bates received national recognition for his contributions to science this year with a Scientific Accomplishment Award from the American Thoracic Society. Dr. Carny was appointed a Fellow of the Royal College of Physicians, and received the President’s Distinguished university Citizenship and Service Award from the University of Vermont. Dr. Dixon was named the 2020 Research Laureate in the Larner College of Medicine. Dr. Farkas was awarded a Gold Humanism Award for his services during COVID. Dr. David Kaminsky received the Robert Crapo Memorial Lifetime Achievement Award in Pulmonary Diagnostics, and Dr. Dan Weiss received the College of Medicine Research Mentor of the year award.

The Division is committed to education and training, and trains 2 clinical fellows per year in pulmonary and critical care medicine, as well as a number of pre and post-doctoral research students. At an institutional level, Dr. Huggett continues to lead the very successful Teaching Academy, which is a nationally recognized program, and a tremendous resource for our faculty and trainees alike.

The last year has been a busy and successful year for the Division as outlined in detail for all members of the Division below.

Faculty

Gilman Allen III, MD Professor of Medicine Director of Critical Care Services

MaryEllen Antkowiak, MD Assistant Professor of Medicine Co-Director Critical Care Services Ramasubramanian Baalachandran, MBBS Assistant Professor of Medicine Jessica Badlam, MD Assistant Professor of Medicine

Jason H.T. Bates, PhD DSc Professor of Medicine Department of Molecular Physiology & Biophysics

Jan Kirk Carney, MD MPH Professor of Medicine Associate Dean for Public Health

Ryan Clouser, DO Associate Professor of Medicine Network Medical Officer for Network Regional Transport System Anne E. Dixon, MA, BM BCh Professor Medicine Director, Pulmonary Disease and Critical Care Medicine Director of Clinical Research, Vermont Lung Center Kelsey Gleason Donovan, ScD Assistant Professor Environmental Epidemiology, Global Health, Humanitarian Disaster Resilience and Response Joshua Farkas, MD Associate Professor of Medicine

Garth Garrison, MD Associate Professor of Medicine Program Director, Pulmonary and Critical Care Fellowship Co-Director, Lung Cancer Screening Program Victoria Hart, PhD Assistant Professor Epidemiology, Biostatistics Kathryn N. Huggett, PhD Director, Teaching Academy at the UVM College of Medicine Robert Larner, MD ’42 Professor in Medical Education Assistant Dean for Medical Education

Curriculum design and evaluation Faculty development Medical education research

Charles Irvin, PhD Professor Department of Molecular Physiology & Biophysics Associate Dean for Faculty Affairs

David Kaminsky, MD Professor of Medicine Medical Director, Pulmonary Function Lab

Pulmonary physiology, pulmonary function testing, asthma, COPD C. Matthew Kinsey, MD, MPH Assistant Professor of Medicine Director of Interventional Pulmonary

-Quantitative imaging and computational modeling for identification of lung cancer

-Application of endobronchial ultrasound transbronchial needle aspiration for development of novel precision medicine therapies for lung cancer -Interventional trials for COPD

Suman Majumdar, MD Assistant Professor of Medicine Prema Menon, MD, PhD Associate Professor of Medicine

Katherine Menson, MD Assistant Professor of Medicine Katelin Morrissette, MD Assistant Professor of Medicine Polly E. Parsons, MD E.L. Amidon Chair and Professor of Medicine

Matthew E. Poynter, PhD

Professor Director of the Cellular, Molecular, and Biomedical Sciences Graduate Program Associate Director of the Vermont Lung Center Associate Director of the Multidisciplinary Training in Lung Biology T32 Training Grant

Immunobiology of asthma Pathophysiology of obese asthma Alcohol-induced immunosuppression

Renee Stapleton, MD, PhD Professor of Medicine Charlotte Teneback, MD Associate Professor Medical Director, Pulmonary Rehabilitation Director, Adult Cystic Fibrosis Center Director, Cystic Fibrosis Therapeutic Development Center

Cystic fibrosis clinical care and research Pulmonary rehabilitation clinical practice and research

Zachary Weintraub, MD Assistant Professor of Medicine Daniel Weiss, MD, PhD Professor of Medicine

Fellows

Morgan ClarkColler, MD Brittany Duchene, DO Emily Ducomb, MD Syed Moin Hassan, MD Elena Kozakewich, MD Patrick Neilan, MD

Nurse Practitioners and Physician Assistants:

Abe Sender, PA Sarah Wagner, NP

Suzanne DeCapua, PA

Graduate Students, Post-doctoral Fellows, MD PhD Students: Jason H.T. Bates, PhD DSc Axel Masquelin – PhD student in Biomedical Engineering Dylan Casey – PhD student in Data Science Vitor Mori - postdoctoral associate (Daymon Runyon Fellow) Anne E. Dixon, MA, BM BCh

Ravi Chandrasakaren, PhD

Swati Bhatawadaker, PhD, 2019-2021

Brittany Duchene, MD

C. Matthew Kinsey, MD, PMP Axel Masquelin

Vitor Mori PhD Heng Tan MD (Medical Student) Emily DuComb (PCCM Fellow

Matthew E. Poynter, PhD

JJ Bivona, CMB doctoral student Amanda Fastiggi, CMB doctoral student Paola Pena, CMB doctoral student

Madeleine Mank, MPH student Renee Stapleton, MD, PhD Joseph J. Bivona, III (graduate student mentor)

Christian Pulcini, MD, Assistant Professor (research/faculty mentor) Katharine Cheung, Assistant Professor (research/faculty mentor)

Daniel Weiss, MD, PhD Post-docs: Nigel Farrow PhD

Grad students: Evan Hoffman, Joy Barua Masters student: Alicia Tanneberger

Endowed Professorships: Kathryn N. Huggett, PhD Robert Larner, M.D. ’42 Professor of Medical Education

Leadership in Professional Societies: Gilman Allen, MD

Second elected 3-year term on SCCM Congress Planning Committee (Society of Crit Care Med)

Jessica Badlam, MD

Joined the Pulmonary Hypertension Association’s (PHA) HCP Education and Support Implementation Committee this year.

Jan Carney, MD, MPH 2021-2023 American College of Physicians, Member, Board of Regents 2021-2022 American College of Physicians, Member, Ethics, Professionalism, and

Human Rights Committee 2020-2022 American College of Physicians, Member, Credentials Committee

Anne E. Dixon, MA, BM BCh

American Thoracic Society Nominating Committee, Chair

American Lung Association Scientific Advisory Committee, Chair American Lung Association, National Board of Directors Executive Committee, Member

Victoria Hart, PhD ASPPH: Transformative Educational Models & Pedagogy Expert Panel - panelist

Kathryn N. Huggett, PhD AAMC Northeast Group on Educational Affairs, Member-at-Large (term completed April 2021)

Academies Collaborative Steering Committee, Steering Committee Member Emerita David Kaminsky, MD

2021: Speaker and Co-Chair: Physiological Phenotyping and Treatable Traits. International Conference, American Thoracic Society, Virtual.

2021: Faculty and Organizer: Race/Ethnicity in Pulmonary Function Testing Workshop, International Conference, American Thoracic Society, Virtual.

C. Matthew Kinsey, MD, MPH

American Association of Bronchology and Interventional Pulmonology Board of Directors

Polly E. Parsons, MD

American Thoracic Society: Chair, Assembly Chair Forum Member, Planning and Evaluation Committee

Renee Stapleton, MD PhD

American Thoracic Society Board of Directors, 2019-2021 Critical Care Assembly Chair, 2019-2021 Unrepresented Patients Working Group, member 2016-2021

Canadian Critical Care Nutrition Clinical Practice Guidelines Committee, External Panel Member, 2008-present Chair of Data Safety Monitoring Board, “The NEUROlogically-impaired Extubation Timing Trial (NEURO-ETT),” 2016-present. International Consensus on the use of High Flow Therapy (HFT) with Nasal Cannula, Member, March 2018-2021. Member of Data Safety Monitoring Board, “Facilitating Communication Study (FCS2),” 2019-present Member of Data Safety Monitoring Board, “Phase 2 RCT of low dose inhaled carbon monoxide in ARDS,” 2019-present Chair of Data Safety Monitoring Board, “Arrest Respiratory Failure Due to Pneumonia (ARREST Pneumonia) Trial”, NIH funded, MPIs J Levitt, E Festic, O Gajic,

K Mahaffey, M Matthay, 2019-present Member of Data Safety Monitoring Board, “Impact of Resident Scheduling on Patient and Resident Outcomes (INCURS) Trial”, CIHR funded, MPIs D. Piqette and C. Parshuram, 2019-present

Daniel Weiss, MD, PhD Chief Scientific Officer: International Society for Cell and Gene Therapies (ISCT)

ISCT Board of Directors Editorships and Editorial Boards: Anne E. Dixon, MA, BM BCh

Up-To-Date Section Editor Springer Press, Respiratory Medicine Series, book series editor

Kathryn N. Huggett, PhD AMA Journal of Ethics, Editorial Board Member Charles Irvin, PhD

Editorial Board, COPD Journal Matthew E. Poynter, PhD Editorial Board member, American Journal of Respiratory Cell and Molecular Biology Renee Stapleton, MD PhD

Murray & Nadel’s Textbook of Respiratory Medicine. Co-Editors: V. Courtney Broaddus, Lynn M. Schnapp, Joel D. Ernst, Talmadge E. King Jr, Stephen C. Lazarus, Renee D. Stapleton.

Elsevier Saunders, Philadelphia, 2021.

Daniel Weiss, MD, PhD Editorial Boards: American Journal of Respiratory Cell and Molecular Biology, Cytotherapy, Molecular Therapy

Study Sections and Federal Advisory Boards: Jason H.T. Bates, PhD DSc

Chaired a NIH Study Section reviewing SBIT/STTR grant proposals Member of the Scientific Advisory Council for the Parker B Francis Foundation Anne E. Dixon, MA, BM BCh

Member, Special Emphasis Panel for Childhood Asthma in Urban Settings Clinical Research

Network, RFA-AI-19-073 (U01) and RFA-AI-19-074 (UM1), October 2020 NHLBI’s National Asthma Education and Prevention Program (NAEPP) EPR4 Guideline Panel – Topic Team Leader: (2018-2020) American Board of Internal Medicine Pulmonary Examination Chair, VA Merit Review for Pulmonary: 2020- NIAID: DSMB for COVID-19 trial, member

Charles Irvin, PhD

External Advisory Committee, NIH COBRE (PI: Rounds), Brown University External Advisory Committee, NIH NHLBI T32 (PI: Levy, Brigham and Women’s

Hospital, Boston External Advisory Committee, NIH NIGMS COBRE (PI: Madden) Dartmouth College

External Advisory Committee, NIH NHLBI T32 (PI: Wise), Johns Hopkins, Baltimore External Advisory Committee, NIH COBRE (PI: Stewart), Nemours, Delaware

External Advisory Committee, NIH COBRE (PI: Jeyaseelan) LSU, Baton Rouge, LA David Kaminsky, MD Member, American Lung Association Research Grant Award Study Section C. Matthew Kinsey, MD, MPH NIH, NCI Developmental Therapeutics Polly E. Parsons, MD

Scientific Director, Parker B. Francis Fellowship Program

Chair, NHLBI Petal Network DSMB

Matthew E. Poynter, PhD NHLBI T32 Special Emphasis Panel, June 2021 Renee Stapleton, MD PhD

Member of NHLBI Clinical Trials Review Committee (CLTR, standing study section), June 2020-present

Daniel Weiss, MD PhD NIH/VA COVID Response Special Emphasis Panel

NSF grant reviewer 6 different data safety and monitoring boards

Major Faculty Awards: Gilman Allen, MD Nominated for the Gold Humanism Award Jason H.T. Bates, PhD DSc Recognition Award for Scientific Accomplishments, American Thoracic Society.

Jan Carney, MD, MPH 2020 Fellow, Royal College of Physicians (FRCP). 2019-2020 President’s Distinguished University Citizenship and Service Award, University of Vermont Anne E. Dixon, MA, BM BCh 2020 Research Laureate Award, Larner College of Medicine, University of Vermont Josh Farkas, MD

Gold humanism award (selected as a humanism champion for the annual Gold Foundation gala)

Victoria Hart, PhD

LCOM Teaching Academy 2021 Curriculum Development & Education Scholarship Award - recipient

David Kaminsky, MD

2021 -American Thoracic Society Dr. Robert Crapo Memorial Lifetime Achievement Award in Pulmonary Diagnostics

Polly E. Parsons, MD Edward Livingston Trudeau Medal

Elected member: American Clinical and Climatological Association

Daniel Weiss, MD, PhD College of Medicine Research Mentor Award 2020 Grants – list all active by faculty member, PI Jason H.T. Bates, PhD DSc R01 HL130847 PI: Bates/Dixon 03/15/2016 - 2/28/2022 NIH/NHLBI Role: Co-MPI 0.12 calendar months Non-Allergic Late-Onset Asthma of Obesity: Pathophysiology and Therapy U01 HL139466 PI: Suki/Bates 09/01/2018 - 08/31/2023 NIH/NIBIB Role: Co-MPI 3 calendar months A multi-scale computational model of the extracellular matrix of the lung

R01 HL142702 PI: Bates/Nieman/Gaver 09/10/2018 - 06/30/2022 NIH/NHLBI Role: Co-MPI 3 calendar months Preserving epithelial barrier integrity in ventilator-induced lung injury. P20 GM125498 PI: Kirkpatrick 12/01/2018-11/30/2023 NIH/NIGMS Role: Core Leader 3 calendar months Translational research to prevent and control global infectious diseases (Translational Global Infectious Diseases Research Center, TGIR) Jan Carney, MD, MPH Northern New England Clinical and Translational Research Network Grant National Institutes of Health (NIH) Maine Medical Center and Larner College of Medicine at UVM (Grant U54 GM115516) 2017 – 2022 Role: Core Director, Rural Health Research and Community Engagement Core Robert Wood Johnson Foundation, Systems for Action. The Impact of Global Budgets and Community Health Workers on Health, Health Equity and Cross-Sector Interconnectedness in Vermont. 2020-2023 Role: Co-Investigator. PI: Adam Atherly, PhD, Director Center for Health Services Research Anne E. Dixon, MA, BM BCh R34 HL135361 05/01/17 – 04/30/2022 NIH/NHLBI (NCE) Role: PI Trial of Roflumilast in Asthma Management (TRIM) This is a study to pilot test the feasibility of a trial of roflumilast for the treatment of obese patients with poorly controlled asthma at two sites (University of Vermont and University of Arizona) R01HL133920 08/15/16-07/31/2021 NIH/NHLBI Role: MPI Obese Allergic Asthma and the Impact of Weight Loss on Airway Epithelial Function The objective of this proposal is to investigate the contribution of specific cells and their secreted mediators that are released from visceral adipose tissue of obese allergic asthmatics to the mitochondrial function of airway epithelial cells and their activation by allergen, which

then cause the structural alterations and methacholine hyperresponsiveness that manifest in severe disease in obese allergic asthmatics. R01HL136917 09/04/2018-07/31/2023 NIH/NHLBI Role MPI Mitochondrial Redox Perturbations in Obese Allergic Asthma This is a proposal to investigate targeting mROS production and signaling through a peroxiredoxin 3-FoxM1 signaling pathway. Studies will be performed in lean and obese asthmatics, and lean and obese healthy controls, and lean and obese mouse models of asthma. R01 HL138708 08/03/2017 – 06/30/2021 NIH/NHLBI Role: Co-I DUOX1 and mitochondria in obese asthma The majority of severe asthmatics in the U.S. are obese, and obese asthmatics often respond poorly to standard therapy. Allergic inflammation and metabolic alterations due to obesity are associated with oxidative stress, yet the contribution(s) of oxidative mechanisms to disease pathology are not well understood. This project will address the importance of the NADPH oxidase DUOX1, a major oxidant source within the respiratory epithelium, combined with mitochondrial dysfunction, as an important feature of metabolic disease in mediating redox-dependent processes leading to altered or exaggerated allergic inflammation due to obesity. American Lung Association 08/01/00-05/31/2021 Role: Co-PI Asthma Clinical Research Center: The major goals of this project are to participate in a nationwide network of clinical research studies in diverse patient populations with asthma. UVMMC 1/1/2021-12/30/2021 Role: PI Treatment of mitochondrial oxidative stress for severe COVID-19 in people with obesity Kelsey Gleason Donovan, ScD Gund COVID-19 Rapid Research Fund Co-Investigator (Bose (PI)) 02/10/21 - 11/10/21 Victoria Hart, PhD Ongoing research support on NNE-CTR – NIH U54 GM115516

Kathryn N. Huggett, PhD 2018-2020 AAMC NEGEA grant Haidet, P (PI) 07/01/18-12/30/20* Student Perspectives About Learning: An Important Influence on Evaluations of Teaching? Role: Co-Investigator *Extension granted for Covid-19 AAMC Opioid Education Challenge Grant Berns S; Lounsbury K (PI) 08/09/19-03/31/21 Responding to the Training and Development Needs of Academic Health Centers Role: Collaborator Charles Irvin, PhD American Lung Association (PI: Irvin) 06/30/2021-07/01/1026 Airways Clinical Research Center (ACRC) Role: Principal Investigator of the Northern New England Consortium (NNEC) ALA-ACRC Major goal are to investigate the pathogenesis of asthma in the format of a multi-center network. I am the PI of the NNEC study site and we currently are recruiting applicants for both NIH sponsored studies and industry sponsored studies. T32 HL076122, NIH/NHLBI (Irvin/Poynter) 04/01/2004-04/30/2024 Multidisciplinary Training in Lung Biology Role: MPI The major goal of this training grant is to produce outstanding, independent biomedical scientists who investigate the mechanisms, manifestations, preventions and cures for lung disorders. This grant supports both pre and postdoctoral fellows. R35 HL135828 (Janssen-Heininger) 01/01/2017-12/31/2023 NIH/NHLBI S-glutathionylation chemistry in fibrotic lung remodeling Role: Co-Investigator The goal of this proposal is to understand the importance of the process of S-glutathionylation in patients with asthma or pulmonary fibrosis, and in mouse models of these diseases. The goal is to understand how this process of S-glutathionylation works, and whether the enzymes that regulate this process can be a target for more specific drugs. We believe that these questions are important for translation into clinical practice as we already have data with compounds that can be used clinically.

R25 GM116701 04/01/2016-02/28/2021 Now NCE NIH/NIGMS Fostering entrepreneurship in biomedical research Role: PI The goal of this training grant is to increase the entrepreneurship environment in biomedical research within the University of Vermont as well as other IDeA states (Maine, New Hampshire, Rhode Island, Puerto Rico and Alaska) by developing common courses and workshops. UT2 GM130176 (Reder) 09/01/2018-08/31/2021 NIH/NIGMS Subcontract with Celdera Medical DRIVEN: Accelerating Medical Entrepreneurship in the Northeast Role: Academic Co-PI The goal of this grant is to establish a regional hub to facilitate investigators of the Northeast IDeA states to become successful entrepreneurs David Kaminsky, MD Northern New England Clinical and Translational Research Network Feasibility of Home Monitoring in Patients with COPD Exposed to Wood Smoke PI: Kaminsky - 07/01/21-06/30/22

UVM Medical Center Foundation Grant Longitudinal Analysis of Lung Function in COVID-19 Patients PI: Kaminsky - 10/12/20-04/12/22 American Lung Association - Asthma Clinical Research Center PI: Charles G. Irvin, Ph.D. Role on Project: Co-Investigator (5%) - 7/1/04-6/30/21 US Department of Defense Beta Blockers for the Prevention of Acute Exacerbations of COPD PI: Mark Dransfield, MD Role on Project: Co-investigator (1%) - 10/1/19-9/30/21 United Therapeutics, Inc. Changes in the Diffusing Capacity of the Lung for Carbon Monoxide (DLCO) in Response to Vasodilator Therapy in Patients with Pulmonary Arterial Hypertension PI: David Kaminsky, MD (< 5%) - 5/1/13-open

C. Matthew Kinsey, MD, MPH 1K23HL133476-01, NIH National Heart, Lung, and Blood Institute 09/01/16 -06/30/21 CT Characteristics of Emphysema for Evaluation of Pulmonary Nodules This research focuses on leveraging the morphologic and vascular characteristics of emphysema to help determine if a lung nodule may be cancer. Role: PI Johnson and Johnson Investigator Initiated Trial Award- Approved, Anticipated 11/01/2020 - 10/31/2022 Phase 1 Trial of Intratumoral Cisplatin for Early Stage Resectable Lung Cancer (PI) Matthew E. Poynter, PhD 1 R01 HL142081 (Poynter) 04/01/2018 – 03/31/2022 NIH/NHLBI Ketone Body Supplementation in Obese Asthma Role: PI VLC Pilot Project (Poynter) 05/01/2021-04/30/2022 Vermont Lung Center Exploiting Exercise Enhanced Protein Synthesis to Augment mRNA Vaccine Translation Role: PI R01-HL133920 (Poynter & Dixon) 08/15/2016 – 07/30/2021 NIH Obese allergic asthma and the impact of weight loss on airway epithelial function Role: MPI R01 HL143452 (Stapleton, Toth, Files, & Poynter) 09/15/2018-06/30/2022 NIH/NHLBI Effects of Exercise on Inflammation-Induced Lung and Muscle Injury in Critical Illness (NEXIS-FLAME) Role: MPI T32-HL076122 (Poynter & Irvin) 05/01/2019 - 04/30/2024 NIH/NHLBI

Multidisciplinary Training in Lung Biology Role: MPI 2 R01 HL085646-09 (van der Vliet) 09/01/2017 -08/31/2022 NIH/NHLBI Dual Oxidase in Airway Epithelial Injury and Inflammation Role: Co-I R01 HL138708 (van der Vliet) 08/03/2017-06/30/2021 NIH/NHLBI DUOX1 and Mitochondria in Obese Asthma Role: Co-I R01 HL122383-06 (Anathy) 05/01/2020 – 04/30/2024 NIH/NHLBI Endoplasmic reticulum stress signaling in allergen induced airway remodeling Role: Co-I R03 AI151525 (Wargo) 04/23/2020- 04/22/2022 NIH/NIAID Klebsiella pneumoniae pathogenesis in the obese lung Role: Co-I R56 AG062105 (Dumas) 09/15/2019 - 08/31/2020 NIH/NIA Fatty Acid Effects on Brain Functioning in Normal Aging Role: Co-I NDC 2777 (Kraft) 11/01/2017 – 12/31/2020 National Dairy Council Full-Fat Yogurt and Glucose Tolerance Role: Co-I Renee Stapleton, MD PhD Nutrition and Exercise in Critical Illness (The NEXIS Trial): A Randomized Trial of Combined Cycle Ergometry and Amino Acids in the ICU R01 HL132887, 4/01/2017-3/31/2022 NIH/NHLBI

Role: Contact PI Effects of Exercise on Inflammation-Induced Lung and Muscle Injury in Critical Illness (NEXIS-FLAME) R01 HL143452, 09/15/2018-06/30/2022 NIH/NHLBI Role: Contact PI Improving Palliative Care for Older Seriously Ill Hospitalized Patients and Their Families: A Randomized Trial of an Informed Assent Communication Intervention about CPR R01 AG050698, 5/01/2016-2/28/2022 (currently in NCE) NIH/NIA Role: PI Novel Arm Restraint for Critically Ill Patients To Reduce Immobility, Sedation, Agitation and Cognitive Impairment R42 AG059451, 4/01/18-6/30/22 (currently in NCE) NIH/NIA Role: Contact PI Ganciclovir to Prevent Reactivation of Cytomegalovirus in Patients with Acute Respiratory Failure and Sepsis UG3 HL147011, 09/15/2020-08/31/2027 NIH/NHLBI Role: MPI Therapeutic modulation of zinc for lung injury and mechanobiology R01 HL142093, 4/01/2019-3/31/2023 NIH/NHLBI Role: Co-Investigator Multidisciplinary Training in Lung Biology T32 HL076122, 05/01/2019-04/30/2024 NIH/NHLBI Role: Co-Director Longitudinal epidemiologic investigation of post-hospitalization health care utilization among ICU survivors in Vermont

Vermont Lung Center Pilot Award 08/01/2020-07/31/2021 Role: PI Charlotte Teneback, MD Cystic Fibrosis Therapeutic Development Center Award, 1/1/15-6/30/21 Cystic Fibrosis Adult Care Center Award, 7/1/20-6/30/21 Daniel Weiss, MD PhD DoD Expansion Award 2019-2022 Clinical Development of a Novel Pleural and Tracheal Sealant VLC Pilot Project 2020-2022 Effects of human lung derived hydrogel organoid culture on lung progenitor cell behaviors. American Lung Association Research Grant 2020-2022 Mechanisms of SARS-CoV-2 Pathogenesis of Type 2 Alveolar Epithelial Cells CF Foundation Pilot and Feasibility (Feinberg PI, Weiss Co-I) 2020-2022 ECM Shrink-wrapped Airway Epithelial Cells Towards Function Engraftment DoD Medical Discovery Award (Weiss co-PI with Dimensions Inx) 2021-2022 Bi-Phasic, Regenerative Tracheal Implants From 3D-Printed Advanced Biomaterials with Integrated Vascularizing and Epithelializing Factors United Therapeutics Inc. 2021-2023 Effect of UNEX-42 (MSC-derived EVs) on SARS-CoV2 Spike Protein Airway and Alveolar Epithelial Biology R21 HD104069 (Finck PI, Weiss Co-I) 2021-2023 Ex vivo bioengineering of functional biomimetic airways for treatment of neonatal and pediatric respiratory conditions Zachary Weintraub, MD PACE Award for Cystic Fibrosis. Publications-peer reviewed, chapters, etc.

Abreu SC, Hampton TH, Hoffman E, Dearborn J, Ashare A, Singh Sidhu K, Matthews DE, McKenna DH, Amiel E, Barua J, Krasnodembskaya A, English K, Mahon B, Dos Santos C, Cruz FF, Chambers DC, Liu KD, Matthay MA, Cramer RA, Stanton BA, Rocco PRM, Wargo MJ, Weiss DJ, Rolandsson Enes S. Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells. American Journal of Physiology - Lung Cellular & Molecular Physiology. 319(6):L908-L925, 2020. Abreu SC, Lopes-Pacheco M, Weiss DJ, Rocco PRM. Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Lung Diseases: Current Status and Perspectives. Frontiers Cell and Developmental Biology. In press 2021. Al Alam D, Ballard PL, Le Saux CJ, Ingram JL, Mariani T, Moore NS, Weiss DJ, Yu M. Human Fetal Tissue Regulation: Impact on Pediatric and Adult Respiratory-Related Research. Annals of the ATS. In press 2020. Ather JL, Van Der Vliet KE, Mank MM, Reed LF, Dixon AE, Poynter ME. Obese Adipose Tissue Modulates Pro-inflammatory Responses of Mouse Airway Epithelial Cells. Am J Physiol Regul Integr Comp Physiol 2021 Ather, J.L., Van der Vliet, K., Mank, M.M., Reed, L.F., Dixon, A.E., and M.E. Poynter. Obese Adipose Tissue Modulates Pro-Inflammatory Responses of Mouse Airway Epithelial Cells. American Journal of Physiology – Regulatory, Integrative, and Comparative Biology, June 2, 2021. doi: 10.1152/ajpregu.00316.2020. PMID 43105399. Atherly A, Van Den Broek-Altenburg E, Hart V, Gleason K, Carney J. Consumer Reported Care Deferrals Due to the COVID-19 Pandemic, and the Role and Potential of Telemedicine: Cross-Sectional Analysis. JMIR Public Health Surveill. 2020 Sep 14;6(3):e21607. PMID: 32833661; PMCID: PMC7498465 Badlam JB, Badesch DB, Austin ED, Benza RL, Chung WK, Farber HW, Feldkircher K, Frost AE, Poms AD, Lutz KA, Pauciulo MW, Yu C, Nichols WC, Elliott CG; USPHSR Investigators. United States Pulmonary Hypertension Scientific Registry: Baseline Characteristics. Chest 2021 Jan;159(1):311-327. Badlam JB, Kaminsky D. (2021). Wheezing and Stridor. In V.C. Broaddus, J Ernst, T.E. King, Jr, S Lazarus, K.F. Sarmiento, L.M. Schnapp, R Stapleton, and M.B. Gotway (Eds), Murray & Nadel’s Textbook of Respiratory Medicine (7th ed.). Elsevier Badlam JB, Kaminsky DA. Wheezing and Stridor. In: Broaddus VC, Lazarus SC. Eds. Murray and Nadel’s Textbook of Respiratory Medicine, 7th ed., 2021.

Bates JHT, D.P. Gaver, N.M. Habashi, and G.F. Nieman. Atelectrauma versus volutrauma: a tale of two time-constants. Critical Care Explorations. 2:e0299 [doi: 10.1097/CCE.0000000000000299], 2020 Bates JHT, Peters U, Daphtary N, MacLean ES, Hodgdon K, Kaminsky DA, Bhatawadekar S, Dixon AE. Altered Airway Mechanics in the Context of Obesity and Asthma. J Appl Physiol (1985). 2021: 130: 36-47 Bates JHT, Peters U, Daphtary N, MacLean ES, Hodgdon K, Kaminsky DA, Bhatawadekar S, Dixon AE. Altered airway mechanics in the context of obesity and asthma. J Appl Physiol 2020 Oct 29. PMID:33119471. Bates JHT, U. Peters, N. Daphtary, E.S. MacLean, K. Hodgdon, D.A. Kaminsky, S. Bhatawadekar, and A.E. Dixon. Altered airway mechanics in the context of obesity and asthma. Journal of Applied Physiology. 130: 36-47, 2021 Bates JHT. Theory and measurement of respiratory resistance. In: Cotes’ Lung Function. 7th edition. R.L. Maynard, S.J. Pearce, B. Nemery, P.D. Wagner, and B.G. Cooper, Eds. Wiley, pp. 217-229, 2020. Berger KI, Adam O, Dal Negro RW, Kaminsky DA, Shiner RJ, Burgos F, de Jongh FHC, Cohen I, Fredberg JJ. Validation of a novel compact system for the measurement of lung volumes. Chest. 2021 Feb 2:S0012-3692(21)00208-7. doi: 10.1016/j.chest.2021.01.052. Online ahead of print. PMID: 33539839 Bhakta NR, Kaminsky DA. Pulmonary Function Testing, Principles. In: Broaddus VC, Lazarus SC. Eds. Murray and Nadel’s Textbook of Respiratory Medicine, 7th ed., 2021. Bhatawadekar SA, Peters U, Walsh RR, Daphtary N, MacLean ES, Mori V, Hodgdon K, Kinsey CM, Kaminsky DA, Bates JHT, Dixon AE. Central airway collapse is related to obesity independent of asthma phenotype. Respirology. 2021 Jan 5. doi: 10.1111 Bhatawadekar SA, Peters U, Walsh RR, Daphtary N, MacLean ES, Mori V, Hodgdon K, Kinsey CM, Kaminsky DA, Bates JHT, Dixon AE.Central airway collapse is related to obesity independent of asthma phenotype. Respirology. 2021 Apr;26(4):334-341. doi: 10.1111/resp.14005. Epub 2021 Jan 5.PMID: 33403681 Bhatawadekar SA, Peters U, Walsh RR, Daphtary N, MacLean ES, Mori V, Hodgdon K, Kinsey CM, Kaminsky DA, Bates JHT, Dixon AE. Central airway collapse is related to obesity independent of asthma phenotype. Respirology 2021;36:334-341. PMID: 33403681.

Bhatawadekar SA, U. Peters, R.R. Walsh, N. Daphtary, E.S. MacLean, V. Mori, K. Hodgdon, C.M. Kinsey, D.A. Kaminsky, J.H.T. Bates, and A.E. Dixon. Central airway collapse is related to obesity independent of asthma phenotype. Respirology. 26: 334-341[doi: 10.1111/resp.14005], 2021 Binks AP, LeClair RJ, Willey JM, Brenner JM, Pickering JD, Moore JS, Huggett KN, Everling KM, Arnott JA, Croniger CM, Zehle CH. Changing Medical Education, Overnight: The Curricular Response to COVID-19 of Nine Medical Schools. Teaching and Learning in Medicine. 2021 Feb 18:1-9. PMID: 33706632. Bivona III, J.J., Crymble, H., Guigni, B.A., Stapleton, R.D., Files, D.C., Toth, M.J., Poynter, M.E., and B.T. Suratt. Macrophages Augment the Muscle Inflammatory Response Through TNFα Following LPS-Induced Acute Lung Injury. FASEB Journal, 35(4):e21462 (2021). PMC7970444. Bivona JJ, Crymble HM, Guigni BA, Stapleton RD, Files DC, Toth MJ, Poynter ME, Suratt BT. Macrophages Augment the Muscle Inflammatory Response Through TNFα Following Acute Lung Injury. FASEB J. 2021 Apr;35(4):e21462. doi: 10.1096/fj.202002275RR Borger V; Weiss DJ; Anderson JD; Borras FE; Bussolati B; Carter DRF; Dominici M; Falcon-Perez JM; Gimona M; Hill AF; Hoffman AM; de Kleijn D; Levine BL; Lim R; Lotvall J; Mitsialis SA; Monguio-Tortajada M; Muraca M; Nieuwland R; Nowocin A; O'Driscoll L; Ortiz LA; Phinney DG; Reischl I; Rohde E; Sanzenbacher R; Thery C; Toh WS; Witwer KW; Lim SK; Giebel B. ISEV and ISCT statement on EVs from MSCs and other cells: considerations for potential therapeutic agents to suppress COVID-19. Cytotherapy. 2020 May 16. Brannan JD, Kaminsky DA, Hallstrand TS. Approach to the Patient with Exercise-Induced Bronchoconstriction. In: Burks AW, Holgate ST, O’Hehir RE, Broide DH, Bacharier LB, Khurana Hershey GK, Peebles RS, Eds. Middleton’s Allergy, 9th ed. New York: Elsevier, 2020. Cancio M, Ciccocioppo R, Rocco PRM, Levine BL, Bronte V, Bollard CM, Weiss DJ, Boelens JJ, Hanley P. Emerging trends in COVID-19 treatment: learning from inflammatory conditions associated with cellular therapies. Cytotherapy. 2020 May 7:S1465-3249(20)30657-5. doi: 10.1016/j.jcyt.2020.04.100. Online ahead of print.PMID: 32565132. Cheung KL, Tamura MK, Stapleton RD, Rabinowitz T, LaMantia MA, Gramling R. Feasibility and Acceptability of Telemedicine Facilitated Palliative Care Consultations in Rural Dialysis Units. J Palliative Med 2021 J Palliat Med. 2021 Jan 19. doi: 10.1089/jpm.2020.0647. Online ahead of print Chia, S. B., et al. (2020). "Dysregulation of the glutaredoxin/S-glutathionylation redox axis in lung diseases." Am J Physiol Cell Physiol 318(2): C304-C327

Chia, S.B., Nolin, J.D., Aboushousha, R., Erickson, C., Irvin, C.G., Poynter, M.E., van der Velden, J., Taatjes, D.J., van der Vliet, A., Anathy, V., and Y.M.W. Janssen-Heininger. Glutaredoxin deficiency promotes activation of the transforming growth factor beta pathway in airway epithelial cells, in association with fibrotic airway remodeling. Redox Biology, 37:101720 (2020). PMC7509797. Claudia C dos Santos1*, Hajera Amatullah1, Chirag Vaswani1, Michael Kim1, Yuexin Shan1, Shirley H.J. Mei3, Katalin Szaszi1, Raquel Herrero4, Jose Angel Lorente4,5,6, Andrés Esteban4, Philip Marsden1, Pingzhao Hu7, Weiss J. Daniel J. Weiss8, Duncan J. Stewart3, and W. Conrad Liles6Liles9. Mesenchymal Stromal (stem) Cell (MSC) Therapy Modulates miR-193b-5p Expression to Attenuate Sepsis-Induced Acute Lung Injury. In press European Resp J, 2021. Cloutier MM, Baptist AP, Blake KV, Brooks EG, Bryant-Stephens T, DiMango E, Dixon AE, Elward KS, Hartert T, Krishnan JA, Lemanske RF Jr, Ouellette DR, Pace WD, Schatz M, Skolnik NS, Stout JW, Teach SJ, Umscheid CA, Walsh CG. 2020 Focused Updates to the Asthma Management Guidelines: A Report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group. JACI 2020: https://doi.org/10.1016/j.jaci.2020.10.003 Cloutier MM, Dixon AE, Krishnan JA, Lemanske RF Jr, Pace W, Schatz M. Managing Asthma in Adolescents and Adults: 2020 Asthma Guideline Update From the National Asthma Education and Prevention Program. JAMA 2020 Dec 8;324(22):2301-2317.doi: 10.1001/jama.2020.21974 Conrad DJ, Billings J, Teneback C, Koff J, Rosenbluth D, Bailey BA, Jain R.J. Multi-dimensional clinical phenotyping of a national cohort of adult cystic fibrosis patients.Cyst Fibros. 2021 Jan;20(1):91-96 Dixon AE, Blake KV, DiMango EA, Dransfield MT, Feemster LC, Johnson O, Roy G, Hazucha H, Harvey J, McCormack MC, Wise RA & JT Holbrook. The challenge of addressing obesity in people with poorly controlled asthma. Obes Sci Pract. 2021;1–8. https://doi.org/10.1002/osp4.533 Dixon AE, Peters U, Walsh R, Daphtary N, MacLean ES, Hodgdon K, Kaminsky DAK & JHT Bates. Physiological signature of late-onset asthma of obesity, ERJ Open Res. 2020 Aug 17;6(3):00049-2020. PMCID: PMC7430141 Dixon AE, Peters U, Walsh R, Daphtary N, MacLean ES, Hodgdon K, Kaminsky DA, Bates JHT. Physiological signature of late-onset nonallergic asthma of obesity. ERJ Open Res 2020;6(3):00049-2020. PMID:32832525.

Domecq JP, Lal A, Sheldrick CR, Kumar VK, Boman K, Bolesta S, Bansal V, Harhay MO, Garcia MA, Kaufman M, Danesh V, Cheruku S, Banner-Goodspeed VM, Anderson HL 3rd, Milligan PS, Denson JL, St Hill CA, Dodd KW, Martin GS, Gajic O, Walkey AJ, Kashyap R; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Outcomes of Patients With Coronavirus Disease 2019 Receiving Organ Support Therapies: The International Viral Infection and Respiratory Illness Universal Study Registry. Crit Care Med. 2021 Mar 1;49(3):437-448. doi: 10.1097/CCM.0000000000004879 Duchene B & AE Dixon. Breathing at Extremes, what is normal? Oct;158(4):1325-1326. doi: 10.1016/j.chest.2020.05.527 Duchene B, Caffry S, Kaminsky DA, Que LG, Poynter ME, Dixon AE. Functional significance of 8-isoprostanes in sinonasal disease and asthma. Respir Med. 2021 Jun 9;185:106506 Duchene, B., Caffry, S., Kaminsky, D.A., Que, L.G., Poynter, M.E., and A.E. Dixon. Functional significance of 8-isoprostanes in sinonasal disease and asthma. Respiratory Medicine, 185:106506 (2021). PMID 34166960. DuComb E, B. Tonelli, Y. Tuo, B. Cole, V. Mori, J.H.T. Bates, G. Washko, R. San Jose Estepar, and C.M. Kinsey. Evidence for expanding invasive mediastinal staging for peripheral T1 lung tumors. Chest 158: 2192–2199, 2020 DuComb EA, Kinsey CM. Response. Chest. 2021 Jan;159(1):447-448. doi: 10.1016/j.chest.2020.08.2078.PMID: 33422219 No abstract available. DuComb EA, Tonelli BA, Tuo Y, Cole BF, Mori V, Bates JHT, Washko GR, San José Estépar R, Kinsey CM. Evidence for Expanding Invasive Mediastinal Staging for Peripheral T1 Lung Tumors. Chest. 2020 Nov;158(5):2192-2199. doi: 10.1016/j.chest.2020.05.607. Epub 2020 Jun 26.PMID: 32599066 Clinical Trial Enes SR and Weiss DJ. Bioartificial lung based on de- and recellularization approaches: Historical Perspective. ERS Educational Publications. In press 2020. Enes SR and Weiss DJ. Bioartificial lungs based on de- and recellularisation approaches: a historical perspective. European Respiratory Society Breathe 2020 16: 200168; DOI: 10.1183/20734735.0168-2020. Enes SR, Hampton TH, Barua J, McKenna DH, dos Santos CC, Amiel E, Asahre A, Liu KD, Krasnodembskaya AD, English K, Stanton BA, Rocco PRM, Matthay MA, Weiss DJ. Healthy

versus Inflamed Lung Environments Differentially Effect MSCs. European Respiratory Journal. In press 2021. Enes SR, Krasnodembskaya AD, English K, dos Santos CC, Weiss DJ. Research progress on strategies that can enhance the therapeutic benefits of MSCs in respiratory diseases. Frontiers in Pharmacology, section Respiratory Pharmacology. In press 2021. Enes SR, Uriarte JJ, Pouliot RA, Weiss DJ. Clinical Application of Stem/Stromal Cells in COPD. In: Stem Cell-Based Therapy for Lung Disease. Springer 2020. Enes SR, Weiss DJ. Cell Therapy for Lung Disease: Current Status and Future Prospects Journal. Current Stem Cell Reports,1-10. DOI: 10.1007/s40778-020-00171-5. Enes SR, Weiss DJ. Lung Cell Therapy: Current status and future prospects. In press 2020. Farkas JD, Long B, Koyfman A, Menson K. (2020). BRASH Syndrome: Bradycardia, Renal Failure, AV Blockade, Shock, and Hyperkalemia. The Journal of Emergency Medicine. doi:10.1016/j.jemermed.2020.05.001 Farkas JD, Long B, Koyfman A, Menson K. BRASH Syndrome: Bradycardia, Renal Failure, AV Blockade, Shock, and Hyperkalemia. J Emerg Med. 2020 Aug;59(2):216-223. doi: 10.1016/j.jemermed.2020.05.001. Epub 2020 Jun 18. PMID: 32565167 Finley C, Dugan MJ, Carney JK, Davis WS, Delaney TV, Hart V, Holmes BW, Stein GS, Katrick R, Morehouse H, Cole B, Bradford LS, Boardman MB, Considine H, Kaplan NC, Plumpton M, Schadler L, Smith JJ, McAllister K. A Peer-Based Strategy to Overcome HPV Vaccination Inequities in Rural Communities: A Physical Distancing-Compliant Approach. Crit Rev Eukaryot Gene Expr. 2021;31(1):61-69. PMID: 33639056; PMCID: PMC8128079 Finley C, Dugan MJ, Carney JK, Davis WS, Delaney TV, Hart VC, Holmes BW, Stein GS, Katrick R, Morehouse H, Cole B, Bradford LS, Boardman MB, Considine H, Kaplan NC, Plumpton M, Schadler L, Smith JJ, McAllister K. A Peer-Based Strategy to Overcome HPV Vaccination Inequities in Rural Communities: A Physical Distancing-Compliant Approach. Crit Rev Eukaryot Gene Expr. 2021;31(1):61-69. doi: 10.1615/CritRevEukaryotGeneExpr.2021036945. PMID: 33639056; PMCID: PMC8128079 Folch EE, Mahajan AK, Oberg CL, Maldonado F, Toloza E, Krimsky WS, Oh S, Bowling MR, Benzaquen S, Kinsey CM, Mehta AC, Fernandez-Bussy S, Flandes J, Lau K, Krishna G, Nead MA, Herth F, Aragaki-Nakahodo AA, Barisione E, Bansal S, Zanchi D, Zgoda M, Lutz PO, Lentz RJ, Parks C, Salio M, Perret K, Keyes C, LeMense GP, Hinze JD, Majid A, Christensen M, Kazakov J, Labarca G, Waller E, Studnicka M, Teba CV, Khandhar SJ. Standardized Definitions of Bleeding

After Transbronchial Lung Biopsy: A Delphi Consensus Statement From the Nashville Working Group. Chest. 2020 Jul;158(1):393-400. doi: 10.1016/j.chest.2020.01.036. Epub 2020 Feb 14. Freeman K, Z. Miller, R.R. Herrington, P. Buttaravoli, N. Dreyfus, A. Burgess, J. Nickerson, N. Daphtary, and J.H.T. Bates. An oropharyngeal device for airway management of conscious and semiconscious patients: a randomized clinical trial. Journal of the American College of Emergency Physicians. 2: e1244, (DOI: 10.1002/emp2.12440) 2021. Gaver DP, G.F. Nieman, L.A. Gatto, M. Cereda, N.M. Habashi, and J.H.T. Bates. The POOR Get POORer: A Hypothesis for the Pathogenesis of Ventilator-Induced Lung Injury. merican Journal of Respiratory and Critical Care Medicine. 202: 1081-1087, 2020 Graham NR, Strother CA, Whitaker AN, Miles AK, Grier D, McElvany BD, Bruce EA, Botten JW, Poynter ME, Pierce KK, Kirkpatrick BD, Stapleton RD, An G, Crothers JW, Diehl SA. Kinetics and Isotype Assessment of Antibodies Targeting the Spike Protein Receptor Binding Domain of SARS-CoV-2 In COVID-19 Patients as a function of Age and Biological Sex. Clin Transl Immunol 2020; 9:e1189 Graham, N.R., Whitaker, A.N., Strother, C.A., Miles, A.K., Dore Grier, D., McElvany, B.D., Bruce, E.A., Poynter, M.E., Pierce, K.K., Kirkpatrick, B.D., Stapleton, R.D., Gary An, G., Botten, J.W., Crothers, J.W., and S.A. Diehl. Kinetics and Isotype Assessment of Antibodies Targeting the Spike Protein Receptor Binding Domain of SARS-CoV-2 In COVID-19 Patients as a function of Age and Biological Sex. medRxIV, 2020.07.15.20154443 (2020). PMC7386516. Graham, N.R., Whitaker, A.N., Strother, C.A., Miles, A.K., Dore Grier, D., McElvany, B.D., Bruce, E.A., Poynter, M.E., Pierce, K.K., Kirkpatrick, B.D., Stapleton, R.D., Gary An, G., Botten, J.W., Crothers, J.W., and S.A. Diehl. Kinetics and Isotype Assessment of Antibodies Targeting the Spike Protein Receptor Binding Domain of SARS-CoV-2 In COVID-19 Patients as a function of Age and Biological Sex. Clinical and Translational Immunology, 9(10):e1189 (2020). PMC7541824. Haverkamp, H. C., et al. (2021). "Spirometric Response to Bronchodilator and Eucapnic Voluntary Hyperpnea in Adults With Asthma." Respir Care 66(8): 1282-1290 Herrmann J, V. Mori, J.H.T. Bates, and B. Suki. Modeling lung perfusion abnormalities to explain early COVID-19 hypoxemia. Nature Communications. 11: 4883 [https://doi.org/10.1038/s41467-020-18672-6], 2020 Ikonomou L and Weiss DJ. Turning the tide on unproven cell-based interventions. Chest. 2020 Apr;157(4):774-775.

Ikonomou L, Wagner DE, Gilpin SE, Weiss DJ, Ryan AL. Technological advances in study of lung regenerative medicine: perspective from the 2019 Vermont lung stem cell conference. In press Cytotherapy, 2020. Imlay H, Dasgupta S, Boeckh M, Stapleton RD, Rubenfeld GD, Chen Y, and Limaye AP. Risk Factors for Cytomegalovirus (CMV) Reactivation and Association with Clinical Outcomes in Critically IllAdults with Sepsis: A Pooled Analysis of Prospective Studies. J Infect Dis 2021 (In press) Irvin, C. G. (2021). "Preface: "Imaging the Lung in 3D: Pictures with Impact"." Histochem Cell Biol 155(2): 157-158 Irwin and Rippe – ME Antkowiak and GB Allen. Up To Date – “Invasive Mechanical Ventilation in Acute Respiratory Failure Complicating Chronic Obstructive Pulmonary Disease”, “Acute Respiratory Failure due to Acute Respiratory Distress Syndrome and Pulmonary Edema”, 9th Edition (in process) Kaminsky DA, Chapman DG. Asthma and lung mechanics. Compr Physiol 2020;10(3):975-1007. PMID:32941682 Kaminsky, DA, Grosset DG, Kegler-Ebo, DM, Cangiamilla S, Klingler M, Zhao P, Oh C. Natural history of lung function over one year in patients with Parkinson's Disease. Respir Med. 2021 Apr 16;182:106396. doi: 10.1016/j.rmed.2021.106396. Online ahead of print. PMID: 33866196. Kelsey M. Gleason, Linda Valeri, A.H. Shankar, Md Omar Sharif Ibne Hasan, Quazi Quamruzzaman, Ema G. Rodrigues, David C. Christiani, Robert O. Wright, David C. Bellinger, and Maitreyi Mazumdar, “Stunting in early childhood may increase susceptibility to adverse effects of environmental lead exposure on cognition: results from a birth cohort in Bangladesh” Journal of Neurodevelopmental Disorders, 12, 39 (December 2020). Khoury M, Cuenca J, Cruz FF, Figueroa FE, Rocco PRM, Weiss DJ. Current Status of Cell-Based Therapies for Respiratory Virus Infections. European Respiratory Journal, in press 2020. Khoury M, Ikonomou L, Dominici M, LeBlanc K, Levin BL, Weiss DJ. The coronavirus pandemic: a pitfall or a fast-track for validating cell therapy products? Stem Cells and Development, in press 12-20. DOI: 10.1089/scd.2020.0122. Khoury M, Rocco PRM, Phinney DG, Krampera M, Martin I, Viswanathan S, Nolta JA, LeBlanc K, Galipeau J, Weiss DJ. Cell-Based Therapies for COVID-19: Proper Clinical Investigations are Essential. Cytotherapy, in press 2020.

Kinsey CM, R.S.J. Estépar, J.H.T. Bates, B.F. Cole, G. Washko, M. Jantz, H. Mehta. Tumor density is associated with response to endobronchial ultrasound-guided transbronchial needle injection of cisplatin. Journal of Thoracic Disease. 12: 4825-4832, 2020 Kinsey CM, San José Estépar R, Bates JHT, Cole BF, Washko G, Jantz M, Mehta H.J Tumor density is associated with response to endobronchial ultrasound-guided transbronchial needle injection of cisplatin. Thorac Dis. 2020 Sep;12(9):4825-4832. doi: 10.21037/jtd-20-674.PMID: 33145055 Kokoszynska, M., Ubags, N.D., Bivona III, J.J., Ventrone, S., Reed, L.F., Dixon, A.E., Wargo, M.J., Poynter, M.E., and B.T. Suratt. Storage Conditions of High Fat Diets Affect Pulmonary Inflammation. In press, Physiological Reports, June 12, 2021. Kokoszynska, M., Ubags, N.D., Bivona III, J.J., Ventrone, S., Reed, L.F., Dixon, A.E., Wargo, M.J., Poynter, M.E., and B.T. Suratt. Storage Conditions of High Fat Diets Affect Pulmonary Inflammation. In press, Physiological Reports, June 12, 2021. Lee B, J.P. Hanley, S. Nowak, J.H.T. Bates, and L. Hébert-Dufresne. Modeling the Impact of School Reopening on SARS-CoV-2 Transmission. BMC Public Health. 20: 1713 [doi: 10.1186/s12889-020-09799-8], 2020 Lim SK; Giebel B; Weiss DJ; Witwer KW; Rohde E. Re: "Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19" by Sengupta et al. In press, Stem Cells & Development. 2020 Jun 10. Lopes-Pacheco M, Carvalho L, Cruz FF, Khoury M, Weiss DJ, Rocco PRM. Mitochondria-rich Fraction Isolated from Mesenchymal Stromal Cells Reduce Lung and Distal Organ Injury in Experimental Sepsis Critical Care Medicine, in press 2021. Maeshiro R and Carney JK. Public Health is Essential: COVID-19’s Learnable Moment for Medical Education. Academic Medicine, 95(12): 1799-1801. December 2020. Manuel AM, van de Wetering C, MacPherson M, Erickson C, Murray C, Aboushousha R, van der Velden J, Dixon AE, Poynter ME, Irvin CG, Taatjes DJ, van der Vliet A, Anathy V, Janssen-Heininger YMW. Dysregulation of Pyruvate Kinase M2 Promotes Inflammation in a Mouse Model of Obese Allergic Asthma. Am J Respir Cell Mol Biol. 2021 Mar 4. doi: 10.1165/rcmb.2020-0512OC. Online ahead of print. PMID: 33662229 Manuel, A. M., et al. (2021). "Dysregulation of Pyruvate Kinase M2 Promotes Inflammation in a Mouse Model of Obese Allergic Asthma." Am J Respir Cell Mol Biol 64(6): 709-721

Manuel, A.M., van de Wetering, C., MacPherson, M., Erickson, C., Murray, C., Aboushousha, R., van der Velden, J., Dixon, A.E., Poynter, M.E., Irvin, C.G., Taatjes, D.J., van der Vliet, A., Anathy, V., and Y.M.W. Janssen-Heininger. Dysregulation of pyruvate kinase M2 promotes inflammation in murine obese allergic asthma. American Journal of Respiratory Cell and Molecular Biology, doi: 10.1165/rcmb.2020-0512OC 2021). PMID 33662229. Mariana A Antunes, Cassia Lisboa Braga, Tainá Batista De Oliveira, Jamil Zola Kitoko, Ligia Lins De Castro, Debora Goncalves Xisto, Mariana S Coelho, Nazareth Rocha, Eduarda G Martins, Antônio Galina, Daniel J Weiss, José R Lapa E Silva, Miquéias Lopes-Pacheco, Fernanda Ferreira Cruz, Patricia R. M. Rocco. Mesenchymal Stromal Cells from Emphysematous Donors and Their Extracellular Vesicles Are Unable to Reverse Cardiorespiratory Dysfunction in Experimental Severe Emphysema. In press Frontiers in Cell and Developmental Biology, section Stem Cell Research. 2021 Masquelin AH, Cheney N, Kinsey CM, Bates JHT Wavelet decomposition facilitates training on small datasets for medical image classification by deep learning. Histo chem Cell Biol. 2021 Feb;155(2):309-317. doi: 10.1007/s00418-020-01961-y. Epub 2021 Jan 27.PMID: 33502624 Masquelin AH, N. Cheney, C. Matthew Kinsey¬, J.H.T. Bates. Wavelet Decomposition Facilitates Training on Small Datasets for Medical Image Classification by Deep Learning. Histochemistry and Cell Biology. 155: 309-317, (https ://doi.org/10.1007/s00418-020-01961-y) 2021 McClure K, B. Erdreich, J.H.T. Bates, R. McGinnis, A. Masquelin, and S. Wshah. Classification and detection of breathing patterns with wearable sensors and deep learning. Sensors. 20: 6481; doi:10.3390/s20226481, 2020 Menson KE, Mank MM, Reed LF, Walton CJ, Van Der Vliet KE, Ather JL, Chapman DG, Smith BJ, Rincon M, Poynter ME. (2020). Therapeutic Efficacy of IL-17A Neutralization with Corticosteroid Treatment in a Model of Antigen-Driven Mixed Granulocytic Asthma. Am J Physiol Lung Cell Mol Physiol. DOI: 10.1152/ajplung.00204.2020 Menson, K.E., Mank, M.M, Reed, L.F., Walton, C.J., Van Der Vliet, K.E. Ather, J.L., Chapman, D.G., Smith, B.J., Rincon, M., and M.E. Poynter. Therapeutic efficacy of IL-17A neutralization with corticosteroid treatment in a model of antigen-driven mixed-granulocytic asthma. American Journal of Physiology – Lung Cellular and Molecular Physiology, 319(4):L693-L709 (2020). PMC7642900. Mori V, B.J. Smith, B. Suki and J.H.T. Bates. Modeling lung derecruitment in VILI due to fluid-occlusion: The role of emergent behavior. Frontiers in Physiology. 30 October, [https://doi.org/10.3389/fphys.2020.542744], 2020

Morrell ED, Grazioli S, Hung C, Kajikawa O, Kosamo S, Stapleton RD, Gharib S, Amado-Rodriguez L, Albaiceta G, Wurfel MM, Matute-Bello G. Alveolar CCN1 is Associated with Mechanical Stretch and Acute Respiratory Distress Syndrome Severity. Am J Physiol Lung Cell Mol Physiol 2020;319(5):L825-L832 Oliver, A. C., et al. (2021). "Effects of Reduced Nicotine Content Cigarettes on Fractional Exhaled Nitric Oxide (FeNO) and Self-Reported Respiratory Health Outcomes among Smokers with Psychiatric Conditions or Socioeconomic Disadvantage." Nicotine Tob Res Park HE, Gasek N, Hwang J, Weiss DJ, Lee PC. Effect of temperature on gelation and cross-linking of gelatin methacryloyl for biomedical applications. Physics of Fluids.32:3, DOI: 10.1063/1.5144896. 2020 Pouliot RA; Young BM; Link PA; Park HE; Kahn AR; Shankar K; Schneck MB; Weiss DJ; Heise RL. Porcine Lung-Derived Extracellular Matrix Hydrogel Properties Are Dependent on Pepsin Digestion Time. Tissue Engineering - Part C: Methods. 26(6):332-346, 2020 Jun. Roy GS, Daphtary N, Johnson O, Dixon AE, Kaminsky DA, Bates JHT JAP 2021: Feb 11. doi: 10.1152/japplphysiol.00976.2020 Roy GS, Daphtary N, Johnson O, Dixon AE, Kaminsky DA, Bates JHT. Measuring the mechanical input impedance of the respiratory system with breath-driven flow oscillations. J Appl Physiol (1985). 2021 Apr 1;130(4):1064-1071. doi: 10.1152/japplphysiol.00976.2020. Epub 2021 Feb 11. PMID: 33571055 Roy GS, N. Daphtary, O. Johnson, A.E. Dixon, D.A. Kaminsky and J.H.T. Bates. Measuring the mechanical input impedance of the respiratory system with breath-driven flow oscillations. Journal of Applied Physiology. 130: 1064-1071, 2021. Samarelli AV,Tonelli R, Heijink I, Medina AM, Marchioni AM, Bruzzi G, Castaniere I, Andrisani D, Gozzi F, Manicardi L, Moretti A, Cerri A, FantiniR, Tabbì L, Nani CA, Mastrolia I, Weiss DJ, Dominici M, Clini E. Dissecting the role of mesenchymal stem cells in idiopathic pulmonary fibrosis: cause or solution? Frontiers in Pharmacology. In press 2021. Saunders MJ, Haynes JM, McCormack MC, Stanojevic S, Kaminsky DA. How local SARS CoV-2 Prevalence Shapes Pulmonary Function Testing Laboratory Protocols and Practices During the COVID-19 Pandemic. Chest. May 2021 Online ahead of print. Sherese B. Johnson, Malika A. Fair, Lisa D. Howley, Jacob Prunuske, Suzanne B. Cashman, Jan K. Carney, Yumi Shitama Jarris, Lawrence R Dayton, Daniel Blumental, N. Kevin Krane, Nicholas H. Fieback, Alvin H. Strelnick, Emma Morton-Eggleston, Chloe Nickens, and LaVonne Ortega.

Teaching Public and Population Health in Medical Education: An Evaluation Framework. Academic Medicine, 95(12):1853-1863. December 2020 Silva JD, Sue Y, Calfee CS, Delucchi KL. Weiss DJ, McAuley DF, O’Kane C, Krasnodembskaya AD. MSC extracellular vesicles rescue mitochondrial dysfunction and improve barrier integrity in clinically relevant models of ARDS. In press, Eur Resp J, 2020. Silva LHA; Silva MC; Vieira JB; Lima ECD; Silva RC; Weiss DJ; Morales MM; Cruz FF; Rocco PRM. Magnetic targeting increases mesenchymal stromal cell retention in lungs and enhances beneficial effects on pulmonary damage in experimental silicosis. Stem Cells Translational Medicine. 9(10):1244-1256, 2020. Siuba MT, Carroll CL, Farkas JD, Olusanya S, Baker K, Gajic O. The Zentensivist Manifesto. Defining the Art of Critical Care. ATS Sch. 2020 Jul 14;1(3):225-232. doi: 10.34197/ats-scholar.2020-0019PS. PMID: 33870290; PMCID: PMC8043314 Skloot GS, K.L. O’Connor-Chapman, C.B. Schechter, D.J. Markley, and J.H.T. Bates. Forced expiratory time: a composite of airway narrowing and airway closure. Journal of Applied Physiology. 130: 80-86, 2021 Steinmetz-Wood S, Gilbert M, Menson K. (2020). A Case of Diabetic Ketoacidosis in a Patient on an SGLT2 Inhibitor and a Ketogenic Diet: A Critical Trio Not to Be Missed. Case Rep Endocrinol. DOI: 10.1155/2020/8832833 Suki B, J. Herrmann, and J.H.T. Bates. An analytic model of tissue self-healing and its network implementation: Application to fibrosis and aging. Frontiers in Physiology. 29 October, [https://doi.org/10.3389/fphys.2020.583024], 2020. Tanneberger AE, Weiss DJ, Uriarte JJ. Decellularization and Recellularization Methods for Avian Lungs: An Alternative Approach for Use in Pulmonary Therapeutics. In: Bioengineering Technologies. Springer 2020. Tharp WG, Murphy S, Breidenstein MW, Love C, Booms A, Rafferty MN, Friend AF, Perrapato S, Ahern TP, Dixon AE, Bates JHT, Bender SP Body Habitus and Dynamic Surgical Conditions Independently Impair Pulmonary Mechanics during Robotic Assisted Laparoscopic Surgery: A Cross-Sectional Study, Anesthesiology, 2020 Oct 1;133(4):750-763 Tharp WG, S. Murphy, M.W. Breidenstein, C. Love, A. Booms, M. Rafferty, A.F. Friend, S. Perrapato, T.P. Ahern, A.E. Dixon, J.H.T. Bates, and S.P. Bender. Body habitus and dynamic surgical conditions independently impair pulmonary mechanics during robotic-assisted laparoscopic surgery. Anesthesiology. 133: 750-763, 2020

Thiebes AL, Uhl FE, Hauser M, Cornelissen CG, Jockenhoevel S, Weiss DJ. Endoscopic atomization of mesenchymal stromal cells: in vitro study for local cell therapy of the lungs. Cytotherapy epub.1/29/21. Uhl FE, Zhang F, Pouliot RA, Uriarte JJ, Rolandsson Enes S, Han X, Ouyang Y, Xia K, Westergren-Thorsson G, Malmström A, Hallgren O, Linhardt RJ, Weiss DJ. Functional role of glycosaminoglycans in decellularized lung extracellular matrix. Acta Biomater. 2020 Jan 15;102:231-246. Uijtdehaage S, Ho MJ, Harvey E, Dorris CS, Huggett KN. Academies in Health Professions Education: A Scoping Review. Academic Medicine. 2021 May 11. Usmani OS, Han MK, Kaminsky DA, Hogg J, Hjoberg J, Patel N, Hardin M, Keen C, Rennard S, Ble FX, Brown MN. Seven pillars of small airways disease in asthma and COPD-Supporting opportunities for novel therapies. Chest. 2021 Apr 2:S0012-3692(21)00660-7. doi: 10.1016/j.chest.2021.03.047. Online ahead of print. PMID: 33819471 van de Wetering, C., Aboushousha, R., Manuel, A.M., Chia, S.B., Erickson, C., MacPherson, M.B., van der Velden, J.L., Anathy, V., Dixon, A.E., Irvin, C.G., Poynter, M.E., van der Vliet, A., Wouters, E.F.M., Reynaert, N.L., and Y.M.W. Janssen-Heininger. Pyruvate kinase M2 promotes expression of proinflammatory mediators in house dust mite-induced allergic airways disease. Journal of Immunology, 204(4):763-774 (2020). PMC6994838. van den Broek-Altenburg EM, Atherly AJ, Diehl SA, Gleason KM, Hart V, MacLean CD, Barkhuff DA, Levine MA, Carney JK. Jobs, Housing, and Mask Wearing: Cross-Sectional Study of Risk Factors for COVID-19. JMIR Public Health Surveill. 2021 Jan 11;7(1):e24320. PMID: 33315576; PMCID: PMC7800904 Viswanathan S, Ciccocioppo R, Galipeau J, Krampera M, LeBlanc K, Martin I, Moniz K, Nolta JA, Phinney DG, Shi Y, Szczepiorkowski ZM, Tarte, Weiss DJ, Ashford P.Consensus ICCBBA-ISCT statement on standard nomenclature abbreviations for the tissue of origin of Mesenchymal Stromal Cells. Cytotherapy, in press 2021. Wagner DE, Ikonomou L, Gilpin SE, Magin CM, Cruz F, Greaney AM, Magnusson M, Chen YW, Davis B, Vanuytsel K, Rolandsson Enes S, Krasnodembskaya A, Lehmann M, Westergren-Thorsson G, Stegmayr J, Alfasadi HN, Hoffman ET, Weiss DJ, Firth AL. Technological Advances in Study of Lung Regenerative Medicine: Perspective from the 2019 Vermont Lung Stem Cell Conference. Cytotherapy, in press 2020.

Wagner DE; Ikonomou L; Gilpin SE; Magin CM; Cruz F; Greaney A; Magnusson M; Chen YW; Davis B; Vanuytsel K; Rolandsson Enes S; Krasnodembskaya A; Lehmann M; Westergren-Thorsson G; Stegmayr J; Alsafadi HN; Hoffman ET; Weiss DJ; Ryan AL. Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Disease 2019. European Respiratory Journal Open Research. 6(4), 2020 Wancyk H, Jensen T, Weiss DJ, Finck C. Advanced Single Cell Technologies to Guide the Development of Bioengineered Lungs. Am J Physiology in press 2021. Weiss DJ, Segal K, Casaburi R, Hayes J, Tashkin D. Effect of mesenchymal stromal cell infusions on lung function in COPD patients with high CRP levels. Respiratory Research, in press 2021 Weiss DJ; Lim SK; Rohde E; Witwer KW; Giebel B. Weiss Response to Sengupta et al. (DOI: 10.1089/scd.2020.0095). Stem Cells & Development. 29(24):1533-1534, 2020. Wilson KC, Kaminsky DA, Michaud G, Sharma S, Nici L, Folz RJ, Barjaktarevic I, Bhakta NR, Cheng G, Chupp GL, Cole A, Dixon AE, Finigan JH, Graham B, Hallstrand TS, Haynes J, Hankinson J, MacIntyre N, Mandel J, McCarthy K, McCormack M, Patil SP, Rosenfeld M, Senitko M, Sethi S, Swenson ER, Stanojevic S, Teodorescu M, Weiner DJ, Wiener RS, Powell CA. Restoring Pulmonary and Sleep Services as the COVID-19 Pandemic Lessens: From an Association of Pulmonary, Critical Care, and Sleep Division Directors and American Thoracic Society-coordinated Task Force. Ann Am Thorac Soc. 2020 Jul 14. doi: 0.1513/AnnalsATS.202005-514ST. Online ahead of print Wilson KC, Kaminsky DA, Michaud G, Sharma S, Nici L, Folz RJ, Barjaktarevic I, Bhakta NR, Cheng G, Chupp GL, Cole A, Dixon AE, Finigan JH, Graham B, Hallstrand TS, Haynes J, Hankinson J, MacIntyre N, Mandel J, McCarthy K, McCormack M, Patil SP, Rosenfeld M, Senitko M, Sethi S, Swenson ER, Stanojevic S, Teodorescu M, Weiner DJ, Wiener RS, Powell CA. Restoring Pulmonary and Sleep Services as the COVID-19 Pandemic Lessens: From an Association of Pulmonary, Critical Care, and Sleep Division Directors and American Thoracic Society-coordinated Task Force. Ann Am Thorac Soc. 2020 Jul 14. doi: 10.1513/AnnalsATS.202005-514ST. Online ahead of print. PMID: 32663071. Wulf K, Borges N, Huggett K, Blanco M, Binkley P, Moore-Clingenpeel M, Hurtubise L. Personality Compatibility Within Faculty Mentoring Dyads and Perceived Mentoring Outcomes: Survey Results of Academic Medicine Institutions in the USA. Medical Science Educator. 2021 Jan 13:1-4. Yan L, Song Y, Xia K, He P, Zhang F, Chen S, Pouliot R, Weiss DJ, Tandon R, Bates JT, Ederer DR, Mitra D, Sharma P, Davis A, Linhardt RJ. Heparan sulfates from bat and human lung and their binding to the spike protein of SARS-CoV-2 virus,” Carbohydrate Polymers, in press, 2021.

Yohannes AM, N Eakin M, Holbrook JT, Sugar EA, Henderson R, Baker AM, Casper AS, Kaminsky DA, Rea AL, Mathews AM, Que LG, Ramsdell JW, Gerald LB, Wise RA, Hanania, NA. Association of mild cognitive impairment and characteristic of COPD and overall health status in a cohort study. Expert Rev Respir Med 2020, Nov 18:1-7. PMID: 33054443. Book Chapters Jeffries WB, Huggett KN, Szarek J: Lectures. in Dent J. and Harden R.M., eds., A Practical Guide for Medical Teachers, 6th Edition, Edinburgh, Churchill Livingstone; 2021. Dixon AE & S Peters, Obesity and asthma, in Murray and Nadel, Volume 7 Eds: Broadus, Ernst, King, Lazarus, Sarmentio, Schnapp, Stapleton, Gotway, 2020 Elsevier Online Chapters Up-to-Date Dixon AE & AM Nyenhuis, Obesity and Asthma, updated May 2020 Peters S & AE Dixon, Moderate persistent asthma, updated December 2020 Peer-Reviewed Research Articles as Part of a Large Study Team Domecq JP, Lal A, Sheldrick CR, Kumar VK, Boman K, Bolesta S, Bansal V, Harhay MO, Garcia MA, Kaufman M, Danesh V, Cheruku S, Banner-Goodspeed VM, Anderson HL 3rd, Milligan PS, Denson JL, St Hill CA, Dodd KW, Martin GS, Gajic O, Walkey AJ, Kashyap R; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Outcomes of Patients With Coronavirus Disease 2019 Receiving Organ Support Therapies: The International Viral Infection and Respiratory Illness Universal Study Registry. Crit Care Med. 2021 Mar 1;49(3):437-448. doi: 10.1097/CCM.0000000000004879. Peer-Reviewed Invited Review Articles/Statements/Working Group Reports Stapleton RD, Heyland DK. Glycemic control and intensive insulin therapy in critical illness. Up To Date online version 16.3. 2007-present. Last updated May 2021. Section Editors Polly E. Parsons MD and Adrienne G. Randolph MD MSc; Deputy Editor Kevin C. Wilson MD. Website: http://www.uptodate.com/online/content/topic.do?topicKey=cc_medi/13045&selectedTitle=1~150&source=search_result Rochwerg B, Einav S, Chaudhuri D, Mancebo J, Mauri T, Helviz Y, Goligher EC, Jaber S, Ricard J-D, Rittayamai N, Roca O, Antonelli M, Maggiore SM, Demoule A, Hodgson CL, Mercat A, Wilcox ME, Granton D, Wang D, Azoulay E, Ouanes-Besbes L, Cinnella G, Carvalho C, Dessap-Mekontso A, Fraser J, Frat J-P, Gomersall C, Grasselli G, Hernandez G, Jog S, Pesenti A, Riviello ED, Slutsky AS, Stapleton RD, Talmor D, Thille AW, Brochard L, Burns KEA. The Role for High Flow Nasal

Cannula as a Respiratory Support Strategy A Clinical Practice Guideline. Intensive Care Med 2020;46:2226-2237. Books Edited Murray & Nadel’s Textbook of Respiratory Medicine. Co-Editors: V. Courtney Broaddus, Lynn M. Schnapp, Joel D. Ernst, Talmadge E. King Jr, Stephen C. Lazarus, Renee D. Stapleton. Elsevier Saunders, Philadelphia, 2021.

1

Division of Rheumatology and Clinical Immunology Bonita Libman, M.D., Division Chief http://www.med.uvm.edu/medicine/rheumatology

The members of the Division of Rheumatology and Clinical Immunology provide high quality patient care to residents of Vermont, up-state New York and other contiguous communities, teach UVM Medical Center resident physicians and UVM College of Medicine medical students, and perform both bench and clinical research. Our faculty consists of eight physicians, a clinician pharmacist and a nurse practitioner. Over the past 12 months, the Rheumatology Division had over 12,000

patient visits, generating more than 20,000 work RVUs. We provide point of care diagnostic and procedural (guided injections) musculoskeletal ultrasound that is integrated with rheumatology care. We participate in an interdisciplinary metabolic bone clinic in addition to our rheumatology services. We cover inpatient consults at the University of Vermont Medical Center on a 24-7 basis. Our fully accredited rheumatology fellowship program accepts one new fellow annually in an increasingly competitive match. Our fellows receive musculoskeletal ultrasound training and participate in the USSONAR program. The internal medicine residency program continues to participate in an outpatient rheumatology rotation where residents see rheumatology patients with all of the faculty, thus experiencing a variety of practice styles. Faculty and fellows teach various rheumatology topics during the annual Internal Medicine Academic Half Day. Medical students complete one month elective rotations in our outpatient clinic. Each year we participate in the Vermont Integrated Curriculum Connections course teaching 2nd year medical students rheumatology and musculoskeletal physical examination skills. Our faculty engage in clinical research including the effect of janus kinase inhibition on inpatients with COVID pneumonia, and effect of exercise on chronic low back pain. We are actively engaged in QI projects such as VCHIP transition of care program for pediatric patients and effect of telemedicine on Rapid3 scores and patient satisfaction. We continue to collaborate with the Division of Immunobiology on research in molecular physiology in rheumatoid arthritis and lupus patients. Faculty Narandra Bethina, M.D. Associate Professor of Medicine

2

Associate Program Director, Rheumatology Fellowship Training Program Director, Division of Rheumatology Musculoskeletal Ultrasound Clinic • Rheumatoid Arthritis • Psoriatic Arthritis • Scleroderma • Sjogren’s Syndrome • Gout • Autoimmune Disorders • Polymyalgia Rheumatica/Temporal Arteritis • Musculoskeletal Ultrasound Ralph Budd, M.D. University Distinguished Professor of Medicine, Microbiology & Molecular Genetics Director, Immunobiology and Vermont Center for Immunology and Infectious Diseases • Systemic Lupus Erythematosus (SLE) • Inflammatory Arthritis (γδ T cells) • T cell homeostatic proliferation in autoimmune diseases • Metabolic regulation of cell death in the immune system Chi Chi Lau, M.D. Associate Professor of Medicine • Systemic Lupus and related autoimmune conditions • Scleroderma • Inflammatory arthritis • Vasculitis • Laboratory testing in rheumatology Scott Legunn, M.D. Assistant Professor of Medicine • Rheumatoid Arthritis • Polymyalgia Rheumatica/Giant Cell Arteritis • Psoriatic Arthritis/Seronegative Spondyloarthropathies • Crystalline Arthritis (Gout/CPPD) • Vasculitis • Systemic Lupus Erythematosus and related autoimmune conditions Bonita Libman, M.D. Professor of Medicine Division Chief, Rheumatology and Clinical Immunology

3

Program Director, Rheumatology Fellowship Training Program • Systemic Lupus Erythematosus • Rheumatoid Arthritis • Psoriatic Arthritis Alana Nevares, M.D. Assistant Professor of Medicine • Giant Cell Arteritis • ANCA Associated Vasculitis • Autoimmune Eye Disease • Sarcoidosis/Neurosarcoidosis Sanjeev Patil, M.D. Assistant Professor of Medicine • Vasculitis • Rheumatoid Arthritis • Psoriatic Arthritis • Ankylosing Spondylitis • Inflammatory Muscle Disease • Musculoskeletal Sarcoidosis Laura Paxton, M.D. Clinical Assistant Professor of Medicine • Rheumatoid Arthritis • Psoriatic Arthritis • Spondyloarthropathy • Giant Cell Arteritis/Polymyalgia Rheumatica • Gout • Vasculitis

Fellows Jeanne Gosselin, M.D., 2nd year fellow Brendan Thoms, M.D., Ph.D., 2nd year fellow Dawid Czarny, M.D., 1st year fellow Nurse Practitioners and Physician Assistants:

4

Morgan Merchand, APRN Leadership in Professional Societies Narandra Bethina, M.D., member, American College of Rheumatology Musculoskeletal Ultrasound Planning Committee Narandra Bethina, M.D., member, USSONAR Fundamental Education Committee Narandra Bethina, M.D., Educational Mentor, USSONAR (Ultrasound School of North American Rheumatologists) Ralph Budd, M.D., Advisory Committee, New England Immunology Conference Bonita Libman, M.D., member, American College of Rheumatology RheumPAC Committee Alana Nevares, M.D., Reviewer, Abstract Selection Sub-Committee for Orthopedics, Low Back Pain and Rehabilitation, American College of Rheumatology 2020 National Meeting Alana Nevares, M.D., Award Selection Committee, Panamerican League of Associations for Rheumatology (PANLAR) Stimulus and Schumacker Awards Alana Nevares, M.D., Reviewer, Journal of Clinical Rheumatology Editorship Ralph Budd, M.D., Editor, Textbook of Rheumatology 11th edition, 2020 Study Section Ralph Budd, M.D. 2020 NIH Immunity and Host Defense 2020 ZGM1 RCB-9 COBRE Phase I Grant Review NIGMS 2021 ACTS (Arthritis, Connective Tissue, and Skin Biology Section) Faculty Awards

5

Grants Chi Chi Lau, M.D. Rheumatology Research Foundation Medical Student Research Preceptorship Grant ($4000) Ralph Budd, M.D.

NIAID R21 AI151407 Ligands for Human Synovial Gamma/Delta T cells 2020-2022 NIAID T32 AI 055402 Immunology/Infectious Diseases Training Grant

2005-2021 NIGMS P30 GM118228 Vermont Immunobiology/Infections Diseases Center (COBRE Phase III Grant) 2016-2021

Publications

Peer Reviewed Publications

Fawad Aslam, Bryant R England, Amy Cannella, Veronika Sharp, Lily Kao, Jon Arnason, Jemima Albayda, Catherine Bakewell, Shruti Sanghvi, Robert Fairchild, Karina D Torralba, Amy Evangelisto, Paul J DeMarco, Narandra Bethina, Eugene Y Kissin. Ultrasound Doppler and tenosynovial fluid analysis in tenosynovitis. Annals of the Rheumatic Diseases 2020 Jul; 79(7):908-913. DOI: 10.1136/annrheumdis-2020-216927 PMID: 32213497 Fortner, KA, Blanco, LP, Buskiewicz, I, Huang, N, Gibson, PC, Cook, DL, Pederson, HL, Yuen, PST, Murphy, MP, Perl, A, Kaplan, MJ, and Budd, RC. Targeting Mitochondrial Oxidative Stress with MitoQ Reduces NET Formation and Kidney Disease in Lupus-Prone MRL-lpr Mice. Lupus Sci and Med. 2020;7:e000387. doi:10.1136/lupus-2020-000387. Gergi M, Cushman M, Littenberg B, Budd RC. Thrombo-inflammation response to Tocilizumab in COVID-19. Res Pract Thromb Haemost 2020 Sep 25;4(8):1262-1268. doi: 10.1002/rth2.12436. PMID: 33043232 Scharer CD, Fortner KA, Dragon JA, Tighe S, Boss JM, Budd RC. Selective DNA Demethylation Accompanies T Cell Homeostatic Proliferation and Gene Regulation in Lupus-Pron lpr Mice. Immunohorizons 2020 Oct 23:4(10):679-687 doi: 10.4049/immunohorizons.2000078. PMID: 33097564

6

Sanjeev Patil, Carolyn Hilliard, Masumi Arakane, Sreedevi Koppisetti Jenigiri, Elizabeth H. Field, Namrata Singh. Musculoskeletal sarcoidosis: A single center experience over 15 years. Int J Rheum Dis. 2021 Apr;24(4):533-541. doi: 10.1111/1756-185X.14068. Epub 2021 Feb 9. PMID: 33559378 Book Chapters and Non-Peer Reviewed Publications

Department of MedicineUVM Research Funding (Direct & Indirect), FY17-FY21

$18,925,948

$16,060,209

$17,629,335

$17,452,377

$19,208,482

FY17 FY18 FY19 FY20 FY21

Department of MedicineUVM Research Funding (Direct & Indirect) by Division, FY2017-FY2021

Card Derm Endo Geriatrics GIMR GI Hem/Onc ID Immuno Neph Pulm

FY17 $3,228,439 $902,901 $20,000 $1,322,344 $3,359,832 $4,557,661 $4,878 $5,529,893

FY18 $2,600,927 $19,405 $20,001 $1,541,976 $3,148,250 $2,802,232 $5,927,418

FY19 $1,303,415 $39,757 $139,849 $135,055 $20,000 $1,591,123 $1,482,128 $3,100,088 $194,611 $9,623,309

FY20 $1,780,617 $2,000 $20,099 $652,837 $55,574 $3,338,362 $907,387 $2,457,859 $68,957 $8,168,685

FY21 $1,228,086 $3,415 $229,127 $702,411 $19,990 $4,850,390 $1,887,113 $3,575,510 $35,441 $6,676,999

Department of Medicine

FY2021 External UVM Research Funding by Division by PI

Department Principal Investigator Sponsor Project Title Start Date End Date Direct Indirect Total Awarded

Cardiology Correa De Sa, Daniel D. CoreMap, Inc. CoreMap Mapping of Atrial Fibrillation 06/01/2020 05/31/2021 $ 6,637 $ 1,858 $ 8,495

Cardiology Correa De Sa, Daniel D. CoreMap, Inc. Epicardial Mapping of Atrial Fibrillation (AF) 04/15/2021 12/31/2021 $ 4,954 $ 1,486 $ 6,440

Cardiology Correa De Sa, Daniel D. CoreMap, Inc. CoreMap - Testing of Electrode Arrays and Cabling 07/01/2021 12/31/2021 $ 16,525 $ 4,627 $ 21,152

Cardiology Correa De Sa, Daniel D. CoreMap, Inc. CoreMap Mapping of Atrial Fibrillation 03/23/2018 07/23/2023 $ 13,115 $ 7,345 $ 20,460

Cardiology Correa De Sa, Daniel D. CoreMap, Inc. Epicardial Mapping of Atrial Fibrillation (AF) 04/15/2021 12/31/2021 $ 6,678 $ 2,004 $ 8,682

Cardiology Keating, Friederike K. Rutgers University Myocardial Ischemia and Transfusion (MINT) CCC 06/01/2019 05/31/2020 $ 641 $ 359 $ 1,000

Cardiology Keating, Friederike K. Rutgers University Myocardial Ischemia and Transfusion (MINT) - CCC 06/01/2020 05/31/2022 $ 3,000 $ - $ 3,000

Cardiology

Lustgarten, Daniel

Lawrence Medtronic Inc

Pilot Pace HFpEF – Physiologic Accelerated Pacing as a

Treatment in Patients with Heart Failure with Preserved

Ejection Fraction 05/27/2020 05/26/2022 $ 3,500 $ 980 $ 4,480

Cardiology

Lustgarten, Daniel

Lawrence Medtronic Inc

Pilot Pace HFpEF – Physiologic Accelerated Pacing as a

Treatment in Patients with Heart Failure with Preserved

Ejection Fraction 05/27/2020 05/26/2022 $ 5,644 $ 1,580 $ 7,224

Cardiology Schneider, David J. Chiesi USA, Inc. Assessment of the In Vitro Inactivation of Cangrelor 09/16/2020 09/15/2021 $ 80,000 $ 24,000 $ 104,000

Cardiology Schneider, David J. PLX Pharma Inc. PL-ASA-010 04/01/2021 12/31/2021 $ 30,000 $ 12,857 $ 42,857

Cardiology Toth, Michael J.

Natl Inst Arthritis

Musculoskl/NIAMS/NIH Skeletal Muscle Atrophy and Dysfunction in Human Cancer 05/01/2021 04/30/2022 $ 313,824 $ 148,545 $ 462,369

Cardiology Toth, Michael J. Natl Inst on Aging/NIA/NIH

Skeletal muscle atrophy and dysfunction following total knee

arthroplasty 06/01/2020 05/31/2022 $ 287,636 $ 147,255 $ 434,891

Cardiology Toth, Michael J.

University of Massachusetts

Amherst

Sex-specific adaptation to different resistance exercise

programs in older adults 04/01/2021 03/31/2022 $ 20,291 $ 11,363 $ 31,654

Cardiology Spees, Jeffrey L. Greenseal Cannabis Co. Greenseal Research Services Agreement Part 2 09/01/2020 03/31/2021 $ 36,107 $ 16,609 $ 52,716

Cardiology Spees, Jeffrey L. IonOptix LLC Beta Testing Instrumentation and Procedures for Industry 07/01/2021 10/31/2021 $ 13,333 $ 5,333 $ 18,666

Cardiology Total $ 841,885 $ 386,201 $ 1,228,086

Dermatology Piette, Evan University of Pennsylvania

A pragmatic trial of home versus office based narrow band

ultraviolet B phototherapy for the treatment of psoriasis 12/15/2020 03/31/2023 $ 3,415 $ - $ 3,415

Dermatology Total $ 3,415 $ - $ 3,415

Endocrinology Jetton, Thomas Lawrence

Agricultural Research

Service/ARS/USDA Impact of Food and Particulates on Metabolic Risk 09/01/2020 08/31/2023 $ 66,847 $ - $ 66,847

Endocrinology Jetton, Thomas Lawrence

Agricultural Research

Service/ARS/USDA Impact of Food and Particulates on Metabolic Risk 09/01/2020 08/31/2023 $ 70,344 $ - $ 70,344

Endocrinology Jetton, Thomas Lawrence

Agricultural Research

Service/ARS/USDA Impact of Food and Particulates on Metabolic Risk 09/01/2020 08/31/2023 $ 71,429 $ - $ 71,429

Endocrinology Kien, Craig L Yale University

Mechanisms of Obesity and Its Metabolic Complications in

Youth 05/01/2021 04/30/2022 $ 13,146 $ 7,361 $ 20,507

Endocrinology Total $ 221,766 $ 7,361 $ 229,127

Gastroenterology Jensen, Gordon Lee Geisinger Clinic Rural Aging Study (Geisinger) 08/01/2020 07/31/2021 $ 18,173 $ 1,817 $ 19,990

Gastroenterology Total $ 18,173 $ 1,817 $ 19,990

Gen Internal Med Littenberg, Benjamin

PCORI Patient Cntrd Outcomes

Res Inst

Integrating Behavioral Health and Primary Care for Comorbid

Behavioral and Medical Problems 04/01/2016 07/31/2022 $ 356,627 $ 142,651 $ 499,278

Gen Internal Med Sobel, Halle G.

Substance Abuse Mental

Health/SAMHSA

Increasing the Pipeline of MAT Prescribers: DATA Waiver

Training for All Vermont Medical Students at The Larner

College of Medicine 09/30/2020 09/29/2021 $ 95,647 $ 7,651 $ 103,298

Gen Internal Med Van Eeghen, Constance O.

PCORI Patient Cntrd Outcomes

Res Inst Integrating Behavioral Health in Primary Care (IBH-PC) 09/01/2020 08/31/2021 $ 71,311 $ 28,524 $ 99,835

Gen Internal Med Total $ 523,585 $ 178,826 $ 702,411

Hematology Oncology (VCC) Adrianzen Herrera, Diego

Northern N. E. Clinical Oncology

Society

Identifying factors associated with CV disease in MDS. An

analysis of the SEER-Medicare database 04/01/2021 03/31/2022 $ 12,534 $ - $ 12,534

Hematology Oncology (VCC) Ahmed, Shahid Sattar

Northern N. E. Clinical Oncology

Society

How bacteria influence the formation of an immune-escaped

bladder cancer; a pilot correlative study 06/01/2021 05/31/2022 $ 19,994 $ - $ 19,994

Hematology Oncology Cushman, Mary Mount Sinai School of Medicine

Use of High Density Lipoprotein Proteome in the Prediction of

Cognitive Impairment and Alzheimer's Disease: (REGARDS) 01/01/2020 12/31/2020 $ 11,361 $ 6,848 $ 18,209

Hematology Oncology Cushman, Mary

Natl Inst Gen Medical

Sciences/NIGMS/NIH

Vermont Center for Cardiovascular and Brain Health (**CO-PI

Cushman/Nelson) 08/06/2020 05/31/2021 $ 1,800,000 $ 804,345 $ 2,604,345

Hematology Oncology Cushman, Mary

University of Alabama at

Birmingham VCID and Stroke in a Bi-Racial National Cohort 02/01/2021 01/31/2022 $ 138,162 $ 77,371 $ 215,533

Hematology Oncology Cushman, Mary University of Minnesota Epidemiology of Venous Thrombosis and Pulmonary Embolism 03/15/2021 02/28/2022 $ 25,719 $ 14,402 $ 40,121

1 of 4

Department Principal Investigator Sponsor Project Title Start Date End Date Direct Indirect Total Awarded

Hematology Oncology Cushman, Mary

University of North Carolina

Chapel Hill

National Longitudinal Study of Adolescent to Adult Health (Add

Health): Wave VI Cognition and Early Risk Factors for

Dementia Project

01/15/2021 12/31/2021 $ 15,542 $ 8,704 $ 24,246

Hematology Oncology Cushman, Mary

University of North Carolina

Chapel Hill

The National Longitudinal Study of Adolescent Health

Wave VI Core

03/01/2021 12/31/2021 $ 355,432 $ 183,544 $ 538,976

Hematology Oncology Cushman, Mary

University of North Carolina

Chapel Hill

The Add Health Epigenome Resource: Life Course Stressors

and Epigenomic Modifications in Adulthood 04/01/2021 03/31/2022 $ 48,052 $ 26,909 $ 74,961

Hematology Oncology (VCC) Dittus, Kim L.

Vermont AHS Department of

Health VDH Survivorship II 07/01/2020 06/30/2021 $ 46,875 $ 13,125 $ 60,000

Hematology Oncology Greenblatt, Marc Steven Natl Cancer Institute/NCI/NIH

InSiGHT-ClinGen Polyposis/Colon Cancer Variant Curation

Expert Panel 06/10/2021 05/31/2022 $ 203,495 $ 113,916 $ 317,411

Hematology Oncology (VCC) Holmes, Chris Elaine Alliance Foundation Trials, LLC

AFT-28 CANVAS Direct Oral Anticoagulants DOACs versus

LMWH Warfarin for VTE in Cancer A Randomized

Effectiveness Trial CANVAS Trial 09/08/2017 09/07/2021 $ 2,000 $ - $ 2,000

Hematology Oncology (VCC) Rehman, Hibba Tul

Northern N. E. Clinical Oncology

Society

Prevention of sarcopenia in advanced stage NSCLC patients

through combination of a structured exercise program and

dietary optimization 05/01/2021 04/30/2022 $ 10,286 $ - $ 10,286

Hematology Oncology (VCC) Umyarova, Elvira PrECOG, LLC

PrE0905: Randomized Trial of Gilteritinib vs Midostaurin in

FLT3 Mutated Acute Myeloid Leukemia (AML) 06/01/2020 12/31/2999 $ 20,000 $ 6,000 $ 26,000

Hematology Oncology Wood, Marie E.

Northern N. E. Clinical Oncology

Society

Examination of Attitudes, Beliefs and Practices Regarding

Point-of-Care Genetic Testing Among Northern New England

medical Oncologists 10/01/2019 10/01/2021 $ 9,000 $ - $ 9,000

Hematology Oncology Wood, Marie E. Alliance NCTN Foundation

Alliance Cancer Control Program - Prevention Committee Co-

Chair Salary Support 05/23/2020 07/31/2021 $ 47,904 $ 26,826 $ 74,730

Hematology Oncology Wood, Marie E. Dana Farber Cancer Institute

Prospectively Randomized, Placebo-Controlled Phase III Study

to Determine the Effect of Denosumba on Breast Cancer

Prevention in BRCA1 Mutation Carriers 09/15/2020 09/14/2021 $ 20,017 $ 11,210 $ 31,227

Hematology Oncology Zakai, Neil A.

Assn of University Ctrs on

Disabilities

Understanding risk factors and burden of COVID-19 related

thrombosis and or bleeding complications 09/01/2020 07/31/2021 $ 274,829 $ 14,000 $ 288,829

Hematology Oncology Zakai, Neil A.

Assn of University Ctrs on

Disabilities

Understanding risk factors and burden of COVID-19 related

thrombosis and or bleeding complications 09/01/2020 07/31/2021 $ 200,566 $ 112,317 $ 312,883

Hematology Oncology Zakai, Neil A.

Assn of University Ctrs on

Disabilities

Understanding risk factors and burden of COVID-19 related

thrombosis and or bleeding complications 09/01/2020 07/31/2021 $ 672,288 $ 126,000 $ 798,288

Hematology Oncology Zakai, Neil A.

Natl Heart Lung and Blood

Inst/NHLBI/NIH

Thrombosis and Bleeding Risk Assessment in Medical

Inpatients 03/01/2021 02/28/2022 $ 494,962 $ 178,027 $ 672,989

$ 4,429,018 $ 1,723,544 $ 6,152,562

Hematology Oncology Total less 1/2 of Cushman/Nelson COBRE $ 3,529,018 $ 1,321,372 $ 4,850,390

Immunobiology Botten, Jason W. Atreca, Inc

To discover antibodies that target and neutralize Severe Acute

Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). 11/02/2020 11/01/2021 $ 215,119 $ 100,506 $ 315,625

Immunobiology Botten, Jason W. Celdara Medical, LLC

A Novel Broad-Spectrum Agent for Treatment of Viral

Infections 01/01/2021 12/31/2021 $ 84,446 $ 47,290 $ 131,736

Immunobiology Botten, Jason W. IGM Biosciences

SARS CoV-2 Neutralization Assay of Proof of Concept

Multimeric Antibodies 07/14/2020 12/31/2020 $ 15,180 $ 8,501 $ 23,681

Immunobiology Botten, Jason W. IGM Biosciences

SARS CoV-2 Neutralization Assay of Proof of Concept

Multimeric Antibodies 07/14/2020 11/30/2021 $ 265,701 $ 121,073 $ 386,774

Immunobiology Botten, Jason W. IGM Biosciences In-Vivo Efficacy Testing of Human Monoclonal Antibodies 03/01/2021 02/22/2022 $ 229,203 $ 128,354 $ 357,557

Immunobiology Botten, Jason W.

Natl Inst Allergy

Infectious/NIAID/NIH

Deep Sequencing the Lymphocytic Choriomeningitis

Arenavirus Quasispecies to Identify and Functionally Validate

the Molecular Signature of Defective Interfering Particles 06/01/2021 05/31/2022 $ 140,608 $ 54,930 $ 195,538

Immunobiology Budd, Ralph Charles

Natl Inst Allergy

Infectious/NIAID/NIH Vermont Immunology / Infectious Diseases Training Grant 09/01/2020 08/31/2021 $ 124,146 $ 9,372 $ 133,518

Immunobiology Budd, Ralph Charles

Natl Inst Allergy

Infectious/NIAID/NIH Ligands for Human Synovial Gamma/Delta T Cells 04/01/2021 03/31/2022 $ 130,123 $ 34,140 $ 164,263

Immunobiology Budd, Ralph Charles

Natl Inst Gen Medical

Sciences/NIGMS/NIH Vermont Immunology/Infectious Diseases Center 08/01/2020 07/31/2022 $ 50,000 $ 28,000 $ 78,000

Immunobiology Budd, Ralph Charles

Natl Inst Gen Medical

Sciences/NIGMS/NIH Vermont Immunology/Infectious Diseases Center 08/01/2020 07/31/2022 $ 50,000 $ 28,000 $ 78,000

Immunobiology Budd, Ralph Charles

Natl Inst Gen Medical

Sciences/NIGMS/NIH Vermont Immunology/Infectious Diseases Center 08/01/2020 07/31/2022 $ 50,000 $ 28,000 $ 78,000

Immunobiology Budd, Ralph Charles

Natl Inst Gen Medical

Sciences/NIGMS/NIH Vermont Immunology/Infectious Diseases Center 08/01/2020 07/31/2022 $ 50,000 $ 28,000 $ 78,000

Hematology Oncology Total

2 of 4

Department Principal Investigator Sponsor Project Title Start Date End Date Direct Indirect Total Awarded

Immunobiology Budd, Ralph Charles

Natl Inst Gen Medical

Sciences/NIGMS/NIH Vermont Immunology/Infectious Diseases Center 08/01/2020 07/31/2022 $ 90,174 $ 50,498 $ 140,672

Immunobiology Budd, Ralph Charles

Natl Inst Gen Medical

Sciences/NIGMS/NIH Vermont Immunology/Infectious Diseases Center 08/01/2020 07/31/2022 $ 129,474 $ 72,506 $ 201,980

Immunobiology Budd, Ralph Charles

Natl Inst Gen Medical

Sciences/NIGMS/NIH Vermont Immunology/Infectious Diseases Center 08/01/2020 07/31/2022 $ 142,033 $ 79,539 $ 221,572

Immunobiology Budd, Ralph Charles

Natl Inst Gen Medical

Sciences/NIGMS/NIH Vermont Immunology/Infectious Diseases Center 08/01/2020 07/31/2022 $ 184,996 $ 103,598 $ 288,594

Immunobiology Budd, Ralph Charles

Natl Inst Gen Medical

Sciences/NIGMS/NIH Vermont Immunology/Infectious Diseases Center 08/01/2020 07/31/2022 $ 250,000 $ 140,000 $ 390,000

Immunobiology Budd, Ralph Charles

Natl Inst Gen Medical

Sciences/NIGMS/NIH Vermont Immunology/Infectious Diseases Center 08/01/2020 07/31/2022 $ 200,000 $ 112,000 $ 312,000

$ 2,401,203 $ 1,174,307 $ 3,575,510

Infectious Disease Dejace, Jean Baystate Medical Center

Drug Injection Surveillance and Care Enhancement for Rural

Northern New England (DISCERNNE) 08/01/2020 07/31/2021 $ 36,451 $ 20,413 $ 56,864

Infectious Disease Huston, Christopher D.

Natl Inst Allergy

Infectious/NIAID/NIH

Repurposing the EMD-Serono Mini-Library for

Cryptosporidinm Drug Development 02/01/2021 01/31/2022 $ 413,854 $ 40,912 $ 454,766

Infectious Disease Huston, Christopher D.

Natl Inst Allergy

Infectious/NIAID/NIH

Preclinical Optimization of a Parasiticidal Drug for

Cryptosporidiosis 03/01/2021 02/28/2022 $ 517,941 $ 102,330 $ 620,271

Infectious Disease Huston, Christopher D. Scripps Research Institute

UVM, Scripps-Calibr, Wellcome Trust Collaboration: Assay

Work in Support of the Development of New Treatments for

Cryptosporidiosis 01/04/2021 01/03/2024 $ 13,332 $ 2,000 $ 15,332

Infectious Disease Singh, Devika

Vermont AHS Department of

Health Long Term Sequelae Study of COVID-19 06/14/2021 07/31/2022 $ 474,282 $ 265,598 $ 739,880

$ 1,455,860 $ 431,253 $ 1,887,113

Nephrology Cheung, Katharine Lana University of Wisconsin

Best Case/Worst Case: A Multisite Randomized Clinical Trial of

Scenario Planning for Patients with End-Stage Kidney Disease 06/01/2020 02/28/2021 $ 2,200 $ 1,232 $ 3,432

Nephrology Solomon, Richard Jay Dartmouth College

IMPROVE AKI: A Cluster-Randomized Trial of Team-Based

Coaching Interventions to IMPROVE Acute Kidney Injury 06/01/2020 05/31/2021 $ 20,519 $ 11,490 $ 32,009

$ 22,719 $ 12,722 $ 35,441

Pulmonary Irvin, Charles G. Celdara Medical, LLC

DRIVEN: Accelerating Medical Entrepreneurship in the

Northeast 09/01/2020 08/31/2021 $ 116,667 $ 23,333 $ 140,000

Pulmonary Bates, Jason H. T. Boston University

A Multi-Scale Computational Model of the Extracellular Matrix

of the Lung. Project 036993 to be moved from CON000797 to

this award 06/01/2020 05/31/2021 $ 191,670 $ 100,451 $ 292,121

Pulmonary Bates, Jason H. T. Boston University

A Multi-Scale Computational Model of the Extracellular Matrix

of the Lung 06/01/2021 05/31/2022 $ 192,675 $ 101,013 $ 293,688

Pulmonary Dixon, Anne Elizabeth

Natl Heart Lung and Blood

Inst/NHLBI/NIH Mitochondrial Redox Perturbations in Obese Allergic Asthma 08/01/2020 07/31/2021 $ 531,765 $ 235,937 $ 767,702

Pulmonary Dixon, Anne Elizabeth University of Illinois Prevent COPD Exacerbations (RELIANCE) 06/01/2019 05/31/2023 $ 5,000 $ 2,000 $ 7,000

Pulmonary Farrow, Nigel University of Adelaide

MS McLeod Postdoctoral Research Fellowship: Harnessing the

Potential of Airway Stem Cells as a Therapy for Cystic Fibrosis

Lung Disease 03/01/2021 12/31/2021 $ 3,804 $ - $ 3,804

Pulmonary Farrow, Nigel University of Adelaide

MS McLeod Postdoctoral Research Fellowship: Harnessing the

Potential of Airway Stem Cells as a Therapy for Cystic Fibrosis

Lung Disease 03/01/2021 12/31/2021 $ 63,405 $ - $ 63,405

Pulmonary Irvin, Charles G. American Lung Association Airways Clinical Research Center (ACRC) Core Award 07/01/2019 06/30/2020 $ 11,111 $ - $ 11,111

Pulmonary Irvin, Charles G. American Lung Association Airways Clinical Research Center (ACRC) Core Award 07/01/2019 06/30/2020 $ 30,000 $ - $ 30,000

Pulmonary Irvin, Charles G. American Lung Association Airways Clinical Research Center (ACRC) Core Award 07/01/2019 06/30/2020 $ 33,333 $ - $ 33,333

Pulmonary Irvin, Charles G. American Lung Association Airways Clinical Research Center (ACRC) Core Award 07/01/2020 06/30/2021 $ 130,000 $ - $ 130,000

Pulmonary Irvin, Charles G. American Lung Association Lung Health Cohort study 01/01/2021 06/30/2024 $ 20,000 $ - $ 20,000

Pulmonary Irvin, Charles G. American Lung Association Losartan Effects on Emphysema Progress Trial (LEEP) 04/16/2017 06/30/2021 $ 16,620 $ - $ 16,620

Pulmonary Irvin, Charles G. American Lung Association Airways Clinical Research Center (ACRC) Core Award 07/01/2016 12/31/2020 $ 500 $ - $ 500

Pulmonary Kaminsky, David Alan

University of Alabama at

Birmingham

Beta Blockers for the Prevention of Acute Exacerbations of

COPD 10/01/2019 09/30/2021 $ 50,781 $ 14,219 $ 65,000

Pulmonary Kinsey, Charles Matthew

Johnson & Johnson Enterprise

Innovations

A Phase I Trial of Intratumoral Cisplatin for Early Stage,

Resectable, Non-Small Cell Lung Cancer 10/15/2020 10/14/2021 $ 79,781 $ 44,676 $ 124,457

Pulmonary Kinsey, Charles Matthew

Johnson & Johnson Enterprise

Innovations

A Phase I Trial of Intratumoral Cisplatin for Early Stage,

Resectable, Non-Small Cell Lung Cancer 10/15/2020 10/14/2021 $ 4,644 $ 2,600 $ 7,244

Pulmonary Kinsey, Charles Matthew

Natl Heart Lung and Blood

Inst/NHLBI/NIH

Ct Characteristics Of Emphysema For Evaluation Of

Pulmonary Nodules 08/01/2020 07/31/2021 $ 157,554 $ 12,604 $ 170,158

Pulmonary Mori, Vitor

Damon Runyon Cancer Research

Foundation

EBUS-TBNI of Cisplatin Optimization in Heterogeneous Lung

Tumors 05/01/2021 04/30/2022 $ 2,000 $ - $ 2,000

Immunobiology Total

Infectious Disease Total

Nephrology Total

3 of 4

Department Principal Investigator Sponsor Project Title Start Date End Date Direct Indirect Total Awarded

Pulmonary Mori, Vitor

Damon Runyon Cancer Research

Foundation

EBUS-TBNI of Cisplatin Optimization in Heterogeneous Lung

Tumors 05/01/2021 04/30/2022 $ 78,000 $ - $ 78,000

Pulmonary Mori, Vitor

Damon Runyon Cancer Research

Foundation

EBUS-TBNI of Cisplatin Optimization in Heterogeneous Lung

Tumors 05/01/2022 04/30/2023 $ 2,000 $ - $ 2,000

Pulmonary Mori, Vitor

Damon Runyon Cancer Research

Foundation

EBUS-TBNI of Cisplatin Optimization in Heterogeneous Lung

Tumors 05/01/2022 04/30/2023 $ 80,000 $ - $ 80,000

Pulmonary Poynter, Matthew E

Natl Heart Lung and Blood

Inst/NHLBI/NIH

Obese Allergic Asthma and the Impact of Weight Loss on

Airway Epithelial Function 08/01/2020 07/31/2022 $ 497,231 $ 278,449 $ 775,680

Pulmonary Poynter, Matthew E

Natl Heart Lung and Blood

Inst/NHLBI/NIH Ketone Body Supplementation in Obese Asthma 04/01/2021 03/31/2022 $ 287,980 $ 157,651 $ 445,631

Pulmonary Poynter, Matthew E

Natl Heart Lung and Blood

Inst/NHLBI/NIH Multidisciplinary Training in Lung Biology 05/01/2021 04/30/2022 $ 328,630 $ 22,897 $ 351,527

Pulmonary Stapleton, Renee D. Brigham and Women's Hospital

Therapeutic Modulation of Zinc for Lung Injury and

Mechanobiology 04/01/2021 03/31/2022 $ 64,576 $ 36,162 $ 100,738

Pulmonary Stapleton, Renee D. Fred Hutchinson Cancer Center

Ganciclovir to Prevent Reactivation of Cytomegalovirus in

Patients with Acute

Respiratory Failure and Sepsis 09/16/2020 08/31/2021 $ 183,264 $ 102,628 $ 285,892

Pulmonary Stapleton, Renee D. Fred Hutchinson Cancer Center

1/2 Ganciclovir to Prevent Reactivation of Cytomegalovirus in

Patients with Acute Respiratory Failure and Sepsis 09/16/2020 08/31/2021 $ 3,000 $ 1,680 $ 4,680

Pulmonary Stapleton, Renee D. Healthy Design Ltd. Co.

Novel Arm Restraint For Critically Ill Patients To Reduce

Immobility, Sedation, Agitation and Cognitive Impairment 07/01/2020 06/30/2022 $ 343,644 $ 106,829 $ 450,473

Pulmonary Stapleton, Renee D. Healthy Design Ltd. Co.

Novel Arm Restraint for Critically Ill Patients to Reduce

Immobility, Sedation, Agitation and Cognitive Impairment 09/15/2019 06/30/2022 $ 5,769 $ 3,231 $ 9,000

Pulmonary Stapleton, Renee D.

Natl Heart Lung and Blood

Inst/NHLBI/NIH

Effects of Exercise on Inflammation-Induced Lung and Muscle

Injury in Critical Illness (NEXIS-FLAME) 07/01/2020 06/30/2021 $ 582,786 $ 174,455 $ 757,241

Pulmonary Stapleton, Renee D.

Natl Heart Lung and Blood

Inst/NHLBI/NIH

Effects of Exercise on Inflammation-Induced Lung and Muscle

Injury in Critical Illness (NEXIS-FLAME) 09/09/2020 06/30/2021 $ 43,416 $ 20,165 $ 63,581

Pulmonary Stapleton, Renee D.

Natl Heart Lung and Blood

Inst/NHLBI/NIH

Nutrition and Exercise in Critical Illness (The NEXIS Trial): A

Randomized Trial of Combined Cycle Ergometry and Amino

Acids in the ICU 04/01/2021 03/31/2022 $ 572,650 $ 115,252 $ 687,902

Pulmonary Teneback, Charlotte C.

Cystic Fibrosis Fdtn Therapeutics,

Inc Therapeutics Development Center 04/01/2021 03/31/2022 $ 104,094 $ 8,328 $ 112,422

Pulmonary Teneback, Charlotte C. National Jewish Health

Healthcare-Associated Links in Transmission (HALT) of

Nontuberculous Mycobacteria in Patients with Cystic Fibrosis 07/01/2020 06/30/2021 $ 5,000 $ - $ 5,000

Pulmonary Teneback, Charlotte C. Seattle Children's Hospital

Standardized Treatment of Pulmonary Exacerbations II (STOP

2) 01/01/2016 12/31/2999 $ 4,246 $ 340 $ 4,586

Pulmonary Weintraub, Zachary Cystic Fibrosis Foundation Program for Adult Care Excellence (PACE) 10/01/2020 09/30/2021 $ 37,061 $ 2,965 $ 40,026

Pulmonary Weintraub, Zachary Seattle Children’s Hospital

Prospective Evaluation of a Standardized Approach to

Diagnosis (PREDICT) and Treatment (PATIENCE) of

Nontuberculous Mycobacteria Disease in Cystic Fibrosis 01/01/2021 12/31/2021 $ 7,039 $ 563 $ 7,602

Pulmonary Weiss, Daniel Jay Alpha-1 Foundation

2021 Stem Cells, Cell Therapies, and Bioengineering in Lung

Biology and Diseases Conference 07/01/2021 07/30/2021 $ 5,000 $ - $ 5,000

Pulmonary Weiss, Daniel Jay American Lung Association

Mechanisms of SARS-CoV-2 induced type 2 alveolar epithelial

cell pathogenesis 07/01/2020 06/30/2021 $ 100,000 $ - $ 100,000

Pulmonary Weiss, Daniel Jay Dimension Inx.

Bi-Phasic, Regenerative Tracheal Implants From 3D-Printed

Advanced Biomaterials with Integrated Vascularizing and

Epithelializing Factors 05/01/2021 04/30/2023 $ 84,535 $ 47,340 $ 131,875

$ 5,061,231 $ 1,615,768 $ 6,676,999

Total Awarded to Medicine 14,978,855$ 5,531,799$ 20,510,654$

Grand Total Medicine less 1/2 of Cushman/Nelson COBRE 14,078,855$ 5,129,627$ 19,208,482$

Pulmonary Total

4 of 4

Department of MedicineFY 2021 External UVM Research Applications Submitted by DOM Faculty

Department FY20 Count FY20 Dollars FY21 Count FY21 Dollars $ Change % Change

Cardiology 15 5,898,319$ 23 27,315,811$ 21,417,492$ 363.1%

Dermatology 0 -$ 1 176,035$ 176,035$ n/a

Endocrinology 2 889,976$ 6 6,493,695$ 5,603,719$ 629.6%

GIM/Medicine 15 11,679,892$ 11 4,833,919$ (6,845,973)$ -58.6%

Geriatrics 0 -$ 1 325,680$ 325,680$ n/a

Hematology Oncology (includes through VCC) 35 16,804,967$ 30 15,292,171$ (1,512,796)$ -9.0%

Immunobiology 13 4,829,445$ 8 1,774,024$ (3,055,421)$ -63.3%

Infectious Disease 3 908,876$ 5 2,887,274$ 1,978,398$ 217.7%

Nephrology 3 201,698$ 1 72,435$ (129,263)$ -64.1%

Pulmonary 46 14,729,132$ 40 20,852,891$ 6,123,759$ 41.6%

Medicine Total 132 $ 55,942,305 126 $ 80,023,935 $ 24,081,630 43.0%

Division PI Sponsor Project TitleRequested Start

Date

Requested End

Date

Requested

Direct Costs

Requested

Indirect Costs

Requested

Total Costs

Cardiology Correa De Sa, Daniel D. CoreMap, Inc. TASK ORDER #2 Award #34508; CoreMap/UVM 6/1/2020 5/31/2021 6,637$ 1,858$ 8,495$ Cardiology Correa De Sa, Daniel D. CoreMap, Inc. Epicardial Mapping of Atrial Fibrillation (AF) 4/1/2021 6/30/2022 38,345$ 11,504$ 49,849$ Cardiology Correa De Sa, Daniel D. CoreMap, Inc. CoreMap - Stephen Bell - Testing of electrode arrays and cabling 7/1/2021 12/31/2021 16,525$ 4,627$ 21,152$ Cardiology Kelm, Robert John National Institutes of Health/NIH Regulation of Cardiac Remodeling by Purine-Rich Element Binding Protein B 4/1/2022 3/31/2025 750,000$ 408,177$ 1,158,177$ Cardiology Kelm, Robert John Natl Cancer Institute/NCI/NIH Evaluation of PURB as a Molecular Target in Blood Cancer Therapy 7/1/2021 6/30/2023 275,000$ 150,118$ 425,118$ Cardiology Lewinter, Martin M. Kiniksa Pharmaceuticals Corp. Inflammatory Markers in Pericardial Fluid 4/1/2021 3/31/2023 5,000$ 2,800$ 7,800$ Cardiology Schneider, David J. Chiesi USA, Inc. Assessment of the In Vitro Inactivation of Cangrelor 9/1/2020 2/28/2021 80,000$ 24,000$ 104,000$ Cardiology Schneider, David J. Chiesi USA, Inc. Chiesi - Cangrelor Supplement 9/16/2020 9/15/2021 2,400$ 720$ 3,120$

Cardiology Schneider, David J. National Institutes of Health/NIHPrognostic utility of FcGammaRIIa and endothelial microparticles in hospitalized

patients with COVID-199/1/2021 8/31/2025 2,072,074$ 939,369$ 3,011,443$

Cardiology Schneider, David J. National Institutes of Health/NIH Assessment of Individual Risk of Cardiovascular Events by Platelet FcγRIIa 7/1/2021 6/30/2025 3,568,724$ 604,688$ 4,173,412$ Cardiology Schneider, David J. PLX Pharma Inc. PL-ASA-010 4/1/2021 12/31/2021 30,000$ 12,858$ 42,858$ Cardiology Schneider, David J. Prolocor Inc. Development of a Precision Tool to Quantify Platelet FcɣRIIa Expression 4/1/2021 3/31/2022 56,441$ 31,607$ 88,048$

Cardiology Schneider, David J. University of California, Los AngelesPlatelet Expression of FcγRIIa and Arterial Hemodynamics to Predict Recurrent

Stroke in Intracranial Atherosclerosis7/1/2021 6/30/2026 599,134$ 335,516$ 934,650$

Cardiology Schneider, David J. University of California, Los AngelesPlatelet Expression of FcyRlla and Arterial Hemodynamics to Predict Recurrent

Stroke in Intracranial Atherosclerosis4/1/2022 3/31/2027 599,134$ 335,516$ 934,650$

Cardiology Spees, Jeffrey L. Greenseal Cannabis Co. Greenseal Research Services Agreement 9/1/2020 2/28/2021 36,107$ 16,609$ 52,716$ Cardiology Spees, Jeffrey L. IonOptix LLC Beta Testing Instrumentation and Procedures for Industry 7/1/2021 10/31/2021 13,333$ 5,333$ 18,666$ Cardiology Spees, Jeffrey L. National Institutes of Health/NIH Astroglial signaling in aging and vascular dementia 9/1/2021 8/31/2026 1,847,683$ 966,090$ 2,813,773$

Cardiology Spees, Jeffrey L. National Institutes of Health/NIHAstroglial signaling and development of vascular dementia after myocardial

infarction9/1/2021 8/31/2026 2,105,956$ 1,131,030$ 3,236,986$

Cardiology Spees, Jeffrey L. Samba Biologics IncorporatedVasaPlex-based biologics for treatment of reperfusion injury after myocardial

infarction9/1/2021 8/31/2022 191,643$ 107,320$ 298,963$

Cardiology Toth, Michael J. National Institutes of Health/NIHMuscle contraction to benefit skeletal muscle size and function during cancer

treatment4/1/2021 3/31/2026 2,648,990$ 648,063$ 3,297,053$

Cardiology Toth, Michael J. National Institutes of Health/NIH Accelerated aging and functional disability in cancer patients 4/1/2022 3/31/2027 1,754,434$ 897,610$ 2,652,044$ Cardiology Toth, Michael J. Natl Heart Lung and Blood Inst/NHLBI/NIHTransitional rehabilitation in patients undergoing cardiac surgery 1/1/2022 12/31/2026 1,551,569$ 784,777$ 2,336,346$

Cardiology Toth, Michael J. University of FloridaMitochondrial permeability transition as a novel mechanism of chemotherapy-

induced skeletal muscle toxicity9/1/2021 8/31/2026 1,064,059$ 582,433$ 1,646,492$

Dermatology Piette, Evan University of PennsylvaniaA pragmatic trial of home versus office based narrow band ultraviolet B

phototherapy for the treatment of psoriasis11/1/2020 3/31/2023 125,739$ 50,296$ 176,035$

Endocrinology Gupta, Dhananjay Maine Medical Center Cardiovascular Dysfunction and Pathogenesis of Type 2 Diabetes 7/1/2021 6/30/2022 49,999$ 27,799$ 77,798$ Endocrinology Gupta, Dhananjay National Institutes of Health/NIH Vitamin D Signaling and Bioavailability in Preclinical Models of Type 2 Diabetes 9/1/2021 8/31/2026 1,250,000$ 700,000$ 1,950,000$ Endocrinology Gupta, Dhananjay National Institutes of Health/NIH Endoplasmic reticulum stress and pathogenesis of type 2 Diabetes 4/1/2022 3/31/2027 1,250,000$ 700,000$ 1,950,000$ Endocrinology Gupta, Dhananjay US Department of Defense/DOD Vitamin D Signaling and Bioavailability in Preclinical Models of Type 2 Diabetes 3/1/2021 2/28/2025 1,181,509$ 661,645$ 1,843,154$ Endocrinology Jetton, Thomas Lawrence Agricultural Research Service/ARS/USDA USDA-Metabolic Effects of Prenatal Exposure to Particulate Matter 9/1/2020 8/31/2023 204,144$ -$ 204,144$ Endocrinology Jetton, Thomas Lawrence Astra-Zeneca α7-Nicotinic Acetylcholine Receptor Activation as a Treatment for Diabetes 11/1/2020 10/31/2022 300,384$ 168,215$ 468,599$

Gen Internal Med Atherly, Adam J. National Institutes of Health/NIHThe Impact of the Vermont All-Payer Waiver on Primary Care Delivery for Older

Adults and Rural Residents9/1/2021 8/31/2023 275,000$ 154,000$ 429,000$

Gen Internal Med Atherly, Adam J. Robert Wood Johnson FoundationEffect of Community Based Integrated Care on Quality, Cost and Outcomes for

Medicaid Enrollees12/15/2020 6/14/2022 267,857$ 32,143$ 300,000$

Gen Internal Med Atherly, Adam J. Robert Wood Johnson FoundationThe Effect of Support and Services at Home for Older Persons onHealth, Health

Equity and Healthcare Utilization10/15/2021 10/14/2024 446,152$ 53,539$ 499,691$

Gen Internal Med Gleason, Kelsey Megan Dartmouth CollegeRefugees and Risk: evidence for identifying infectious disease transmission and

reducing environmental vulnerabilities6/1/2021 11/30/2022 85,587$ 8,559$ 94,146$

Gen Internal Med Gleason, Kelsey Megan Trust for Public LandsVermont Community Forests: a mixed methods study to deepen understanding of

engaged local land management with health and well-being6/1/2021 5/31/2023 40,856$ 22,879$ 63,735$

Gen Internal Med Oshita, Jennifer Yoshie National Institutes of Health/NIH TBD- F31 9/1/2021 8/31/2023 83,792$ -$ 83,792$ Gen Internal Med Plante, Timothy B. American Heart Association - National The Inflammatory Basis of Hypertension 7/1/2021 6/30/2024 209,992$ 21,000$ 230,992$ Gen Internal Med Plante, Timothy B. Harold S Geneen Charitable Trust Inflammation, Hypercoagulability, and Cardiac Injury in COVID-19 1/1/2021 12/31/2022 249,986$ 24,998$ 274,984$ Gen Internal Med Plante, Timothy B. National Institutes of Health/NIH The Inflammatory Basis of Hypertension 7/1/2021 6/30/2026 723,962$ 57,917$ 781,879$ Gen Internal Med Van Eeghen, Constance O. Agency Healthcare Research Quality/AHRQManagement and Better Prescribing with QI Toolkit and Coaches 4/1/2022 3/31/2027 1,312,230$ 686,149$ 1,998,379$ Gen Internal Med Van Eeghen, Constance O. Maine Medical Center Opioid Prescribing Patterns and Analysis of Secular Trends 7/1/2021 6/30/2022 49,692$ 27,629$ 77,321$

Geriatrics LaMantia, Michael Andrew Northwestern UniversitySociodemographic and Geographic Disparities in Healthcare Utilization in

Alzheimer's Disease and Related Dementias7/1/2021 6/30/2026 208,769$ 116,911$ 325,680$

Hem/Onc- UVMCC Adrianzen Herrera, Diego Gabrielle's Angel Fdtn Cancer Research Clonal Hematopoiesis in Patients with Early Stage Solid Tumors: A Pilot Study 4/1/2021 3/31/2024 204,545$ 20,455$ 225,000$

Hem/Onc- UVMCC Adrianzen Herrera, Diego Hemostasis Thrombosis Research SocietyIdentifying Patient and Treatment Factors Associated with Cardiovascular Disease

Risk and Mortality in Patients with Myelodysplastic Syndromes 7/1/2021 6/30/2023 149,999$ 12,000$ 161,999$

Hem/Onc- UVMCC Adrianzen Herrera, Diego Maine Medical Center TBD 7/1/2021 6/30/2022 39,962$ 22,219$ 62,181$

Hem/Onc- UVMCC Adrianzen Herrera, Diego Northern N. E. Clinical Oncology SocietyIDENTIFYING FACTORS ASSOCIATED WITH CARDIOVASCULAR DISEASE IN

MYELODYSPLASTIC SYNDROMES: AN ANALYSIS OF THE SEER-MEDICARE DATABASE2/1/2021 1/31/2022 12,534$ -$ 12,534$

Page 1 of 4

Division PI Sponsor Project TitleRequested Start

Date

Requested End

Date

Requested

Direct Costs

Requested

Indirect Costs

Requested

Total Costs

Hem/Onc- UVMCC Ahmed, Shahid Sattar Northern N. E. Clinical Oncology SocietyHow bacteria influence the formation of an immune-escaped bladder cancer; a pilot

correlative study3/1/2021 2/28/2022 19,994$ -$ 19,994$

Hem/Onc- UVMCC Dittus, Kim L. Vermont AHS Department of Health Dittus VDH Survivorship III 7/1/2021 6/29/2022 39,062$ 10,937$ 49,999$

Hem/Onc- UVMCC Rehman, Hibba Tul Northern N. E. Clinical Oncology SocietyPrevention of sarcopenia in advanced stage NSCLC patients through combination of

a structured exercise program and dietary optimization2/1/2021 1/31/2022 10,286$ -$ 10,286$

Hem/Onc- UVMCC Wood, Marie E. Alliance NCTN Foundation Alliance NCTN Foundation Research Base-Clinical Trials 8/1/2021 7/31/2022 47,991$ 26,875$ 74,866$

Hem/Onc- UVMCC Wood, Marie E. Maine Medical CenterFeasibility Trial of a Novel Strategy to Increase Genetic Testing Amongst Young Rural

Cancer Survivors 7/1/2021 6/30/2022 49,829$ 27,705$ 77,534$

Hem/Onc- UVMCC Wood, Marie E. National Institutes of Health/NIHClinical and translational significance of a circulating microRNA-based breast cancer

risk signature9/1/2021 8/31/2026 1,676,829$ 939,024$ 2,615,853$

Heme/Onc Cushman, Mary American Society of HematologyEvaluating the Longitudinal Association of Endothelial Dysfunction Markers with

Incident Chronic Kidney Disease in a Cohort of Black and White Adults7/1/2021 6/30/2022 5,000$ -$ 5,000$

Heme/Onc Cushman, Mary Columbia University Vitamin K status in relation to incidence of stroke and trajectory of cognitive decline 4/1/2021 3/31/2026 130,558$ 73,114$ 203,672$

Heme/Onc Cushman, Mary Cornell UniversityTrial of Apixaban vErsus Aspirin in Cancer Patients with IscHemic Stroke: the TEACH2

Randomized Clinical Trial 11/1/2021 10/31/2026 345,594$ 193,534$ 539,128$

Heme/Onc Cushman, Mary Duke University Structural Racism and Biological Embodiment of Risk in Breast Cancer Mortality 7/1/2021 6/30/2026 520,058$ 291,233$ 811,291$

Heme/Onc Cushman, Mary Duke University Structural Racism and Biological Embodiment of Risk in Breast Cancer Mortality 4/1/2022 3/31/2027 527,242$ 295,256$ 822,498$

Heme/Onc Cushman, Mary Mercatus Center at George Mason UUnderstanding Black-White Differences in COVID-19 in the REasons for Geographic

And Racial Differences in Stroke (REGARDS) study8/15/2020 2/14/2021 261,478$ 146,428$ 407,906$

Heme/Onc Cushman, Mary Natl Inst Gen Medical Sciences/NIGMS/NIHLaser speckle visualization of brain perfusion: expanding shared resource in-vivo

imaging8/1/2021 7/31/2022 90,152$ -$ 90,152$

Heme/Onc Cushman, Mary University of California, San FranciscoProteomics of Stroke in the Reasons for Geographic and Racial Differences in Stroke

Cohort4/1/2022 3/31/2027 73,816$ 41,335$ 115,151$

Heme/Onc Cushman, Mary University of Minnesota Epidemiology of Venous Thrombosis and Pulmonary Embolism 4/1/2021 3/31/2022 -$ -$ -$ Heme/Onc Greenblatt, Marc Steven Natl Human Genome Rsrch Inst/NHGRI/NIHCatalog Calibration Collaborative for Clinical Genomics (C4G) 7/1/2021 6/30/2026 3,439,524$ 540,885$ 3,980,409$

Heme/Onc Greenblatt, Marc Steven University of UtahUpgrading Rigor and Efficiency of Germline Cancer Gene Variant Classification for

the 2020s7/1/2021 6/30/2026 272,246$ 142,305$ 414,551$

Heme/Onc Greenblatt, Marc Steven University of UtahUpgrading rigor and efficiency of germline cancer gene variant classification for the

2020s9/1/2021 8/31/2026 212,255$ 118,865$ 331,120$

Heme/Onc Holmes, Chris Elaine Maine Medical Center lmprovingVTE Risk Assessment. Education, and Prophylaxis in Rural Cancer Clinics 5/15/2021 5/14/2022 40,000$ 22,240$ 62,240$

Heme/Onc Holmes, Chris Elaine National Institutes of Health/NIH Platelet FcGammaRIIa and Risk of Venous Thromboembolism in Cancer 12/1/2021 11/30/2023 275,000$ 154,000$ 429,000$

Heme/Onc Jasra, Sakshi Alliance Cancer Control ProgramInvestigating barriers to optimal clinical trial accrual in rural Vermont: A mixed-

methods approach9/1/2020 7/31/2021 44,364$ 24,844$ 69,208$

Heme/Onc Zakai, Neil A. Assn of University Ctrs on DisabilitiesUnderstanding risk factors and burden of COVID-19 related thrombosis and or

bleeding complications9/1/2020 7/31/2021 1,147,683$ 252,317$ 1,400,000$

Heme/Onc Zakai, Neil A. Assn of University Ctrs on DisabilitiesUnderstanding Risk Factors and Burden of COVID-19 Related Thrombosis or Bleeding

Complications 8/1/2021 7/31/2022 1,237,426$ 162,573$ 1,399,999$

Heme/Onc Zakai, Neil A. University of ColoradoNovel Protein Biomarkers for Incident Cardiovascular Heart Disease in a Multi-

ethnic Cohort7/1/2021 6/30/2026 245,510$ 137,486$ 382,996$

Heme/Onc Zakai, Neil A. University of Minnesota Pulmonary Hypertension: Epidemiology, Interventions and Outcomes 7/1/2021 6/30/2025 165,233$ 92,531$ 257,764$ Heme/Onc Zakai, Neil A. University of Minnesota Pulmonary Hypertension: Epidemiology, Interventions and Outcomes 4/1/2022 3/31/2026 166,564$ 93,276$ 259,840$

Immunobiology Botten, Jason W. Atreca, IncMapping the repertoire of human antiviral antibodies during acute SARS-CoV-2

infection10/1/2020 9/30/2021 215,119$ 100,506$ 315,625$

Immunobiology Botten, Jason W. IGM Biosciences SARS CoV-2 Neutralization Assay of Proof of Concept Multimeric Antibodies 7/15/2020 9/30/2020 15,180$ 8,501$ 23,681$ Immunobiology Botten, Jason W. IGM Biosciences SARS-CoV-2 IGM Project #2 (likely amendment on AWD195) 8/15/2020 10/31/2020 11,284$ 6,319$ 17,603$ Immunobiology Botten, Jason W. IGM Biosciences SARS CoV-2 Neutralization Assay of Proof of Concept Multimeric Antibodies 12/1/2020 11/30/2021 265,701$ 121,073$ 386,774$

Immunobiology Botten, Jason W. IGM BiosciencesScreening monoclonal antibodies for therapeutic efficacy in SARS-CoV-2 animal

models3/1/2021 2/28/2022 229,203$ 128,354$ 357,557$

Immunobiology Botten, Jason W. National Institutes of Health/NIH Mapping and Functional Interrogation of the Mammarenavirus Phosphoproteome 4/1/2022 3/31/2024 275,000$ 154,000$ 429,000$

Immunobiology Botten, Jason W. University of New MexicoVirus-Host Interactions that Drive Inflammatory Disease in Orthohantavirus

Infection9/1/2021 8/31/2023 143,710$ 75,074$ 218,784$

Immunobiology Budd, Ralph Charles Celdara Medical, LLC Developing Tumor Immunotherapy Using Gamma-Delta T Cells 4/1/2021 3/31/2022 20,833$ 4,167$ 25,000$ Infectious Disease Huston, Christopher D. National Institutes of Health/NIH Repurposing EMD-Serono Mini-Library for Cryptosporidium 2/1/2021 1/31/2024 1,246,998$ 126,205$ 1,373,203$ Infectious Disease Huston, Christopher D. National Institutes of Health/NIH Methods to study Cryptosporidium drug resistance 4/1/2022 3/31/2024 275,000$ 144,820$ 419,820$

Infectious Disease Huston, Christopher D. Scripps Research Institute UVM-Calibr subcontract: Development of new treatments for cryptosporidiosis 11/1/2020 10/31/2023 13,044$ 1,956$ 15,000$

Infectious Disease Mihavics, Bethany Renee National Institutes of Health/NIHInfluence of malnutrition-associated dysbiosis on the innate immune response to

Cryptosporidium infection9/1/2021 8/31/2024 107,096$ -$ 107,096$

Infectious Disease Singh, Devika Vermont AHS Department of Health Long Term Sequelae Study of COVID-19 5/1/2021 6/30/2022 623,176$ 348,979$ 972,155$

Page 2 of 4

Division PI Sponsor Project TitleRequested Start

Date

Requested End

Date

Requested

Direct Costs

Requested

Indirect Costs

Requested

Total Costs

Nephrology Onuigbo, Macaulay A Maine Medical Center The CKD Express © App – A Patient-Centered Innovative CKD TeleMedicine Program 7/1/2021 6/30/2022 46,552$ 25,883$ 72,435$

Pulmonary Antkowiak, MaryEllen Cleary ContraFect Corporation

A Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy & Safety of a

Single Dose of Exebacase in Adult Patients Receiving Standard-of-Care Antibiotics

for the Treatment of Staphylococcus aureus Bloodstream Infections (Bacteremia)...

7/1/2021 6/30/2022 41,785$ 20,040$ 61,825$

Pulmonary Badlam, Jessica Beatrice American Heart Association - NationalThe role of sex hormones and reproductive factors in pulmonary arterial

hypertension7/1/2021 6/30/2024 209,876$ 20,988$ 230,864$

Pulmonary Badlam, Jessica Beatrice American Lung AssociationThe role of Reproductive Factors and Sex Hormones in Pulmonary Arterial

Hypertension7/1/2021 6/30/2023 100,000$ -$ 100,000$

Pulmonary Badlam, Jessica Beatrice Bayer CorporationThe role of reproductive factors and sex hormones in pulmonary arterial

hypertension7/1/2021 6/30/2023 112,500$ 37,496$ 149,996$

Pulmonary Dixon, Anne Elizabeth American Lung Association Mitochondrial Redox Perturbations in the Pathogenesis of Severe COVID-19 7/1/2021 6/30/2023 200,000$ -$ 200,000$ Pulmonary Dixon, Anne Elizabeth National Institutes of Health/NIH Obesity, diet and metabolic dysfunction in the genesis of lung disease 4/1/2021 3/31/2026 3,005,196$ 842,318$ 3,847,514$

Pulmonary Dixon, Anne Elizabeth University of IllinoisThe ALOHA trial: Addressing Quality of Life, Clinical Outcomes, and Mechanisms in

Adults with Uncontrolled Asthma Following the DASH Dietary Pattern7/1/2021 6/30/2026 432,744$ 240,328$ 673,072$

Pulmonary Farrow, Nigel University of AdelaideHarnessing the Potential of Airway Stem Cells as a Therapy for Cystic Fibrosis Lung

Disease3/1/2021 12/31/2021 68,448$ -$ 68,448$

Pulmonary Irvin, Charles G. American Lung Association Airways Clinical Research Center 7/1/2021 6/30/2022 165,000$ -$ 165,000$ Pulmonary Irvin, Charles G. American Lung Association BI LHC Supplement Grant 4/22/2021 12/15/2024 28,328$ -$ 28,328$

Pulmonary Irvin, Charles G. American Lung Association

The Improving Medication Adherence with Telehealthcare Medication Therapy

Management to Change Health Outcomes in Adolescents and Young Adults with

Asthma (MATCH) trial

5/1/2021 6/30/2022 6,420$ -$ 6,420$

Pulmonary Irvin, Charles G. American Lung Association Airways Clinical Research Center 7/1/2020 6/30/2021 35,000$ -$ 35,000$

Pulmonary Irvin, Charles G. American Lung AssociationAmerican Lung Association-Airways Clinical Research Center - Lung Health Cohort

(ALA-LHC) Study1/1/2021 6/30/2024 14,835$ -$ 14,835$

Pulmonary Irvin, Charles G. Baylor College of Medicine Roles of Allergen Sensitization and T2 Inflammation on Lung Health inYoung Adults 12/1/2021 11/30/2026 59,385$ 33,255$ 92,640$

Pulmonary Irvin, Charles G. Celdara Medical, LLC DRIVEN: Accelerating Medical Entrepreneurship in the Northeast 9/1/2021 8/31/2025 466,668$ 93,332$ 560,000$

Pulmonary Irvin, Charles G. Dartmouth CollegeArsenic Enhances Pro-inflammatory and Inhibits Pro-resolution Pathways in

Response to Influenza Infection Across Generations9/1/2021 8/31/2026 59,990$ 33,595$ 93,585$

Pulmonary Irvin, Charles G. National Institutes of Health/NIH Deep Functional Phenotyping of the ALA Lung Health Cohort 9/1/2021 8/31/2026 2,787,172$ 929,230$ 3,716,402$ Pulmonary Irvin, Charles G. National Institutes of Health/NIH Fostering entrepreneurship in biomedical research 7/1/2021 6/30/2026 2,485,010$ 178,401$ 2,663,411$

Pulmonary Johnson, Olivia K Academy of Nutrition and DieteticsMalnutrition and COVID-19: Evaluation of Nutrition Risk on the Setting of SARS-CoV-

25/1/2021 10/31/2021 1,000$ -$ 1,000$

Pulmonary Kaminsky, David Alan Maine Medical Center Feasibility of Home Monitoring in Patients with COPD Exposed to Wood Smoke 7/1/2021 6/30/2022 41,303$ 22,964$ 64,267$

Pulmonary Kinsey, Charles Matthew Janssen Research & Development, LLCA Phase I Trial of Intratumoral Cisplatin for Early Stage, Resectable, Non-Small Cell

Lung Cancer10/1/2020 9/30/2021 468,924$ 259,237$ 728,161$

Pulmonary Kinsey, Charles Matthew Johnson & Johnson Enterprise InnovationsEvaluation of Intratumoral Drug Delivery in Resected Dog Tumors 7/1/2021 6/30/2023 397,130$ 190,669$ 587,799$ Pulmonary Kinsey, Charles Matthew National Institutes of Health/NIH Optimizing Intratumoral Cisplatin Delivery 4/1/2021 3/31/2026 2,623,063$ 1,172,019$ 3,795,082$ Pulmonary Kinsey, Charles Matthew National Institutes of Health/NIH CT Characteristics of Emphysema for Evaluation of Pulmonary Nodules 8/1/2021 1/31/2022 60,200$ 4,816$ 65,016$

Pulmonary Masquelin, Axel Herve National Institutes of Health/NIH Detecting lung cancer from CT images and patient history using deep neural nets 12/1/2021 10/31/2024 100,491$ -$ 100,491$

Pulmonary Morrissette, Katelin Marie Natl Heart Lung and Blood Inst/NHLBI/NIHAided Diagnosis via Machine Learning for Point of Care Cardiothoracic Ultrasound 9/1/2021 8/31/2023 296,260$ 109,723$ 405,983$

Pulmonary Stapleton, Renee D. Healthy Design Ltd. Co.Novel Arm Restraint for Critically Ill Patients to Reduce Immobility, Sedation,

Agitation and Cognitive Impairment9/15/2019 6/30/2021 5,769$ 3,231$ 9,000$

Pulmonary Teneback, Charlotte C. Cystic Fibrosis Foundation Therapeutics Development Center 4/1/2021 3/31/2022 104,094$ 8,328$ 112,422$

Pulmonary Teneback, Charlotte C. National Jewish HealthHealthcare-Associated Links in Transmission of Nontuberculous Mycobacteria in

Patients with Cystic Fibrosis3/1/2021 2/28/2022 2,500$ -$ 2,500$

Pulmonary Weintraub, Zachary Seattle Children’s HospitalProspective Evaluation of a Standardized Approach to Diagnosis (PREDICT) and

Treatment (PATIENCE) of Nontuberculous Mycobacteria Disease in Cystic Fibrosis6/1/2021 5/31/2026 53,120$ 4,250$ 57,370$

Pulmonary Weiss, Daniel Jay Alpha-1 Foundation2021 Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases

Conference7/12/2021 7/15/2021 5,000$ -$ 5,000$

Pulmonary Weiss, Daniel Jay American Lung Association Mechanisms of SARS-CoV-2 Induced Type 2 Alveolar Epithelial Cell Pathologenesis 7/1/2021 6/30/2022 100,000$ -$ 100,000$

Pulmonary Weiss, Daniel Jay Cystic Fibrosis Foundation Mechanisms of SARS-CoV-2 Pathogenesis of CF Airway Epithelial Cells 1/1/2021 12/31/2022 250,000$ 28,336$ 278,336$

Pulmonary Weiss, Daniel Jay Natl Heart Lung and Blood Inst/NHLBI/NIHStem Cells, Cell Therapies, and Bioengineering in Lung Biology and Lung Diseases 7/1/2021 6/30/2022 30,000$ -$ 30,000$

Pulmonary Weiss, Daniel Jay United Therapeutics CorporationEffect of UNEX-42 (MSC-derived EVs) on SARS-CoV2 Spike Protein Airway and

Alveolar Epithelial Biology6/1/2021 5/31/2023 290,614$ 101,715$ 392,329$

Page 3 of 4

Division PI Sponsor Project TitleRequested Start

Date

Requested End

Date

Requested

Direct Costs

Requested

Indirect Costs

Requested

Total Costs

Pulmonary Weiss, Daniel Jay United Therapeutics CorporationModeling Pulmonary Hypertension Drug Mechanisms of Actions in Pulmonary

Vascular Smooth Cells: Correlation of in silico and in vitro studies7/1/2021 6/30/2022 274,983$ 96,244$ 371,227$

Pulmonary Weiss, Daniel Jay University of ConnecticutEx vivo bioengineering of functional biomimetic airways for treatment of neonatal

and pediatric respiratory conditions9/1/2021 8/31/2023 49,564$ 27,756$ 77,320$

Pulmonary Weiss, Daniel Jay University of Gothenburg Unrestricted support of student Isabelle Ingemansson - University of Gothenburg 9/1/2021 11/30/2021 1,000$ -$ 1,000$

Pulmonary Weiss, Daniel Jay Virginia Commonwealth University Laminin supported junction formation in engineered decellularized lung tissues 9/1/2021 8/31/2025 308,093$ 172,531$ 480,624$

Pulmonary Weiss, Daniel Jay Virginia Commonwealth UniversityBasement Membrane Supported Epithelial Junction Formation in Engineered Lung

Tissues4/1/2022 3/31/2026 308,093$ 172,531$ 480,624$

58,617,026$ 21,406,909$ 80,023,935$

Page 4 of 4

Department of MedicineUVM Medical Center Research Revenue (Direct & Indirect), FY17-FY21

$3,243,560

$3,430,100

$2,908,420

$2,196,358

$3,776,122

2017 2018 2019 2020 2021