News from the University of Kansas Medical Center

DEPARTMENT OF PATHOLOGY & LABORATORY MEDICINE SUMMER 2021

AUGUST 20, 2021

DEPARTMENT CHAIR’S UPDATE

X. Long Zheng, M.D., Ph.D.

Professor and Russell J. Eilers, M.D. Endowed Chair, Department Chair and Service Chief

Email: xzheng2@kumc.edu

I am thrilled to update you on the many activities and accomplishments of the Department of Pathology & Laboratory Medicine this past academic year, in fulfi llment of our Mission, as follows:

Building a strong academic and service infrastructure:

LEADERSHIP TEAM

Reorganization of clinical divisions and reappointment of the Division Directors or Vice Chair: Janet Woodroof, M.D., Division Director of Anatomic Pathology; Fred Plapp, M.D., Ph.D., Vice Chair of Clinical Aff airs and Division of Laboratory Medicine; Andy Godwin, Ph.D., Division Director of Genomic Diagnostics; and

Tim Fields, M.D., Ph.D., Vice Chair for Research and Faculty Development in the Department and Division of Cancer & Developmental Biology.

FACULTY AND STAFF

Recruitment and Onboarding: We have successfully recruited six new faculty members to meet the increasing demands of clinical service, since July 1, 2020. At least fi ve more AP faculty will be needed to accomplish the departmental mission in the next two years. Additional administrative staff have also been hired, and reorganizations implemented to adequately support the growing needs of the department.dep

Faculty Promotions: Six of our faculty were promoted since July 1, 2020, with four receiving full professorship..

LABORATORY SPACE EXPANSION

Major renovation for hemato-pathology and cytopathology reading rooms, pathologist offi ces, and the slide storage room has been completed.

Funding was allocated to hire a consulting fi rm to assist with space planning and design of the lab’s current space. The goal is to understand current usage and determine needed support

for future growth. The tentative timeline is to begin meetings with a consulting fi rm in Mid-August, interviews with department leaders in September/October and fi nalize data and have a business plan developed by Mid-November 2021. In the meantime, negotiation is ongoing with the University of Kansas Health System to allocate funds for establishment of the Mass Spectrometry and Human Leukocyte Antigen (HLA) and antibody testing laboratories.

Providing better patient care, education, and research:

PATIENT CARE

Clinical productivity continues to grow. Our focus has been on increasing both faculty and staff members and building a stronger CP program, as these are unmet needs for better patient care, education, and research at KUMC. Additionally, there has been rapid growth and expansion in our department with the creation of four distinct academic divisions: Anatomic Pathology, Laboratory Medicine, Genomic Diagnostics, and Cancer & Developmental Biology.

ANATOMIC PATHOLOGYAn astonishing number of cases have been signed out (over 41,000) with very few faculty

THIS IS THE OFFICIAL PUBLICATION OF THE DEPARTMENT OF PATHOLOGY & LABORATORY MEDICINE AT THE

UNIVERSITY OF KANSAS MEDICAL CENTER, 3901 RAINBOW BLVD., 3019 DELP, KANSAS CITY, KANSAS 66160

PHONE: (913) 588-7070 | FAX: (913) 588-7073. EMAIL: STHIGPEN2@KUMC.EDU

FOLLOW US ON TWITTER @ KUPATHOLOGY

IN THIS ISSUE:• UPDATE FROM THE CHAIR.................1

• COVID-19 RESPONSE.....................3

• FACULTY NEWS..............................4

• DEPARTMENT NEWS........................6

• ALUMNI NEWS...............................7

• CURRENT TRAINEES.........................8

• RESEARCH &SCHOLARLY ACTIVITIES...................10

• DEPARTMENT HIGHLIGHTS...............14

• UPCOMING EVENTS........................15

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members, less than 17.5 clinical full-time equivalents (cFTE). Thank you for what you do.

LABORATORY MEDICINEThis group has done an extraordinary job of overseeing over 4,000,000 billable tests, transfusion service, and apheresis with just 2.75 (cFTE) laboratory medicine faculty and very limited number of staff and nurses. They also established an in-house SARS-CoV-2 testing program, which has completed over 219, 000 COVID PCR tests alone. Going forward, we will increase the number of laboratory medicine faculty and medical technologists and establish the Transfusion Medicine fellowship in 2022 within the Division of Laboratory Medicine to meet our patient care and education needs.

GENOMIC DIAGNOSTICSCreation of the Division of Genomic Diagnostics, a rapidly expanding fi eld in molecular pathology, is led by a world-renowned scientist Andy Godwin, Ph.D. The clinical laboratories within the division provide over 4,000 molecular oncology tests and 9,000 cytogenetic tests annually. Support for this clinical

testing includes personnel within the Clinical Molecular Oncology Laboratory (led by Drs. Stephen Hyter and Godwin) and the Cytogenetics Laboratory (led by Drs. Patrick Gonzales and Shivani Golem).

CANCER & DEVELOPMENTAL BIOLOGYResearch funding topped $11,024,183 in NIH funding; the department was ranked #22 in 2020 on Blue Ridge Institute for Medical Research, up from #24, among all public and private universities. This also represents a ranking of #11 among state medical schools, up from #13. The division has many world-renowned investigators and scientists who conduct cutting-edge research to fi nd the cure for cancer, neurodegenerative diseases, abnormal pregnancies, kidney diseases, and thrombosis.

EDUCATION

RESIDENCY/FELLOWSHIP PROGRAMS We successfully trained and graduated fi ve Anatomic and Clinical Pathology (AP/CP) residents who also passed their boards. We matched four new residents in Anatomic and Clinical Pathology and welcomed four new fellows: two Cytopathology; one Hematopathology; and one Selective (Surgical) Pathology.

UNDERGRADUATE PROGRAM Post Sophomore Fellows: Two graduates.

GRADUATE PROGRAMM The program has been successfully growing with fi ve new graduate students joining the program.

RESEARCH

As illustrated in the discussion under the Division of Cancer and Developmental Biology, our research faculty are extremely dedicated and successful. The department has contributed only 5% of our clinical revenue to support the education and research within the department. Additionally, the department has created the Pathology Research and Grants Offi ce to support the Pathology Basic Science faculty and their labs with all administrative tasks, including HR, Visas, Salary Funding Changes, Pre-Award Grant Assistance, Post-Award Monthly Grant Reporting, Ordering, Eff ort Certifi cation, Timekeeping/Absence Reporting, Seminar Series, and Promotion & Tenure, etc. For pre-award grant support email pathpreaward@kumc.edu. Email Stacy for additional information at soxley@kumc.edu.

Looking ahead, the department is gaining recognition and reputation at national and international levels. The continuing collaboration between basic science faculty and clinical faculty is the key for our success in innovation and discovery, which will in turn improve our patient care and education at KUMC. I want to thank you for what you do. You have made this department a much better place to work, grow, and enjoy.

Read the chair’s message online: kumc.edu/school-of-medicine/pathology

COVID-19 RESPONSE

In December 2019, as news of an emerging novel coronavirus spread from China, it was readily apparent that we would need to perform molecular diagnostic testing to identify infections in our community. On March 23, ~60 hours after receiving reagents and 15 days after the first COVID-19 positive patient was admitted to the University of Kansas Hospital (TUKSH), our laboratory began testing TUKHS patients for SARS-CoV-2. Our laboratory was the first hospital-based laboratory in the Kansas City metro region to perform SARS-CoV-2 testing and we were rapidly contacted by local hospitals and health departments to assist in testing their patients. To date, we have performed outreach testing for 10 Kansas or Missouri county health departments and seven non-KUH hospitals. In November 2020, we were awarded a contract with the State of Kansas to perform testing for long-term care facilities in nine counties in Western Kansas. Our outreach testing continues to date, and these e�orts are critical to the state and community COVID-19 response.

The COVID laboratory testing team was instrumental in setting up the TUKHS swab clinics at Indian Creek, Battenfeld, and Watkins,

and individuals in nearly every laboratory section, in one way or another, have been involved in the COVID-19 laboratory response.

Notably critical to these e�orts have been the phlebotomy team members at Indian Creek and the Medical O�ce Pavilion, who receive and process outpatient and outreach specimens, the CDA team, who receive and process both outpatient and inpatient specimens, the send outs team, who managed many specimen testing requests prior to go-live, the LIS team, who were essential in specimen tracking and reporting design, and volunteers from throughout the department who helped assemble collection kits, aliquot and label specimens, and perform both COVID and non-COVID testing in the beginning months of the pandemic.

Over the course of the pandemic, technologists in the Microbiology and Special Chemistry laboratory sections performed SARS-CoV-2 testing on five di�erent platforms using 13 independent instruments, 10 of which were purchased (or borrowed) after the initial go-live. Two laboratory renovations were required to support instrumentation and testing volume. To date, we have

performed >230,000 SARS-CoV-2 tests, in addition to supporting increased volumes of existing tests. Nine new technologists were hired and trained into the Special Chemistry section during the first year of the pandemic. Our highest single day positivity rate was 20.06% (November 26, 2020); the largest number of SARS-CoV-2 tests performed in a single day was 1,415 tests (November 20, 2020). Our overall positivity rate to-date is 7.07% and >95% of all tests performed have been reported within 36 hours of collection.

With the increase in testing volume, instrumentation, and expertise, a new laboratory section, Molecular Microbiology, was created, with Marissa Larson as supervisor. This group continues to perform SARS-CoV-2 testing and, as the delta variant becomes the predominant circulating strain in the region, test positivity rate has increased from 2% in the month of June to 9% in the most recent 2-week period. Our testing volume has decreased from the peak in the Fall 2020 but remains significant at ~300-400 tests performed per day. We hope everyone stays safe and gets vaccinated as we continue through this most recent wave of transmission and prepare for the upcoming respiratory viral season.

Rachael Liesman, Ph.D. Clinical Assistant Professor; Director, Clinical Microbiology Laboratory; Director, Molecular Microbiology Laboratory

COVID-19 SAMPLES RECEIVED SINCE MARCH 2020

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EXCELLENCE IN MENTORING AWARD – CONGRATULATIONS, DOCTOR GODWIN!

ANDREW K. GODWIN, PH.D.Chancellors Distinguished Chair in Biomedical Sciences and Endowed ProfessorDivision Director, Genomic Diagnostics, Pathology & Laboratory MedicineProfessor and Director of Molecular Oncology, Pathology & Laboratory MedicineDeputy Director, The University of Kansas Cancer CenterDirector, Biospecimen Repository Core Facility Kansas Bioscience Authority Eminent Scholar

FACULTY NEWS

FACULTY & STAFF ACCOLADES

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This award is given to an associate or full professor in the KU School of Medicine for fi ve or more years, with a current appoint-ment in good standing; who has mentored fi ve or more junior faculty members; with evidence of superb performance in mentoring junior faculty. The presentation of the award will be on Friday, August 20, 2021 at the Virtual School of Medicine Faculty Retreat from 1:00p-3:15p.

“It was my distinct pleasure and honor to nominate Doctor Godwin for this award as evidence of his commitment to mentorship”, Doctor Zheng said. He went on: In all respects, Doctor Godwin exemplifi es the enduring career achievements associated with this award. He is internationally recognized for the impact of his research in molecular biology and genetics of cancer and its direct implications on innovative approaches towards early detection and treatment, for which he has received NIH-supported grant funding consistently since

1993. Doctor Godwin is prolifi cally published and highly cited, is actively involved in national and international editorial boards and has successfully mentored both basic and translational scientists at all levels throughout his illustrious scientifi c career.

Doctor Godwin received the KU School of Medicine’s Achievement Award for mentoring post doctorate students in 2014. Of his awards, he is most proud of being acknowledged for his many years of mentoring. He has mentored well over 100 trainees, including high school students, undergraduates, graduate students, postdoctoral associates/fellows, medical students/fellows, visiting scientists, and junior faculty during his academic career, including supporting fi ve junior faculty through his KIPM COBRE award. His extensive curriculum vitae, mentoring philosophy statement, and letters of support from trainees, demonstrated his worthiness of this award.

CONGR ATUL ATIONS ON BEING NAMED TO THE PATHOLOGIST MAGA ZINE 202 1 POWER LIST!

RACHAEL LIESMAN, PH.D.Clinical Assistant Professor; Director, Clinical Microbiology Laboratory; Director, Molecular Microbiology LaboratoryDoctor Liesman was recognized in the “Front(line) and Center” category, which celebrates those who have been instrumental during the COVID-19 pandemic. The goal of the Power List is to feature the most inspiring people in the various fields o f pathology & laboratory medicine.

thepathologist.com/power-list/2021/frontline-and-center/rachael-liesman

2020-2021 GRADUATION STAR AWARDSThe STAR Teaching Awards are presented as part of our annual graduation ceremony. The awards are presented in two categories, faculty and non-faculty, and are chosen annually by current Pathology residents. The award is given for excellence in teaching.

RESIDENCY PROGRAM LEADERSHIP CHANGESAfter 15 years of service, Doctor Sharad Mathur stepped down as the Associate Program Director for the Residency Program to concentrate on his numerous responsibilities and administrative functions at the KCVA. We welcomed Doctor Nelli Lakis as the new Associate Program Director on June 1st.

KAT PASCHAL, M.S.Assistant Pathologist 2021 STAR Sta� Teaching Award

NELLI LAKIS, M.D., MS.C.Clinical Assistant Professor, Associate Program Director

SHARAD MATHUR, M.D.Volunteer Professor, Chief Pathology & Laboratory Medicine Service, VA Medical Center, Kansas City, MO

STEPHANIE WOOD, M.D. Assistant Professor 2021 STAR Faculty Teaching Award

WELCOME NEW FACULTY

DAFFOLYN RACHAEL FELS-ELLIOTT, M.D., PH.D. – GI-LIVER/THORACICAssistant Professor, July 2021 Doctor Fels-Elliott, completed her residency in Anatomic Pathology at the University of California, San Francisco, CA where she also completed her Surgical Pathology and Gastrointestinal/Liver Fellowships. She joins us from the University of Michigan, where she just finished up a Thoracic Pathology Fellowship.

DANIEL FARRELL, M.D . – HEMATOLOGY/MOLECULAR GENETICSAssistant Professor, August 16, 2021 Doctor Farrell completed his residency in Clinical Pathology at UCI Health, Orange, California. He also completed fellowship trainings in Hematopathology, University of Southern California, and Molecular Genetic Pathology from University of Utah Health, Salt Lake County, UT.

JASMEET S. ASSI, M.D. – BREAST/CYTOPATHOLOGYAssistant Professor, August 16, 2021 Doctor Assi completed his residency training in AP/CP at Baylor College of Medicine, Houston, TX. He also completed fellowship trainings in Breast Pathology at the University of Pennsylvania, and Cytopathology Fellowship at MD Anderson Cancer Center, Houston, TX.

DEVIN SHROCK, M.D. – GYNECOLOGIC CYTOLOGYAssistant Professor, July 2021 Doctor Shrock completed her medical school training here at the University of Kansas School of Medicine. She went on to complete a fellowship in Anatomic Pathology Surgical Pathology, at the University of Iowa Hospitals and Clinics, where she also completed her Surgical Pathology Fellowship and subspecialty in Cytopathology.

MIMI PRECIT, PH.D., M(ASCP) CM – CLINICAL MICROBIOLOGYAssistant Professor, August 2, 2021Doctor Precit joins us from Children’s Hospital of Los Angeles, University of Southern California, where she was a CPEP Postdoctoral Clinical and Public Health Microbiology Fellow. She will be working closely with Dr. Rachel Liesman, the Director of Clinical Microbiology to provide service in her area of expertise.

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DEPARTMENT NEWS

We are excited to share the success and growth of the Graduate Studies program in the department. Currently, we have 13 Ph.D. students in the program. Last year two of our students, Mitch Braun and Diana Acevado, successfully defended their thesis and obtained their Ph.D. degree. Mitch Braun, Ph.D., completed his training under Doctor Godwin’s mentorship and is enrolled in KUMC’s MD-PHD Scientist Training Program. Also, five new graduate students joined the Pathology graduate program. Our students also obtained significant success in getting their own funding. A Ph.D.

student, Regan Scott received a NIH F32 grant. Another student Ananya Ghosh received the Predoctoral Fellowship from the KUMC Biomedical Research Training Program. Ananya also received a President’s award at the 2021 annual meeting of the Society of Reproductive Investigation for her research presentation. All other students are making great contribution to the pathology research program and their contributions lead to strong publications and securing NIH grants in the department. We predict to continue this success in the future.

Rachael Liesman, Ph.D., heads a new clinical laboratory section, Molecular Microbiology. This section, previously within the Special Chemistry section, performs high complexity molecular testing (eg, viral load testing, esoteric molecular microbiology).

GRADUATE STUDIES PROGRAM

NEWLY CREATED MOLECULAR MICROBIOLOGY SECTION

ARDA PETERSON, MBA, MT(ASCP), CLS, LABORATORY DIRECTORThe KU laboratories have been proud to support the region and the state in their COVID-91 testing needs. We have helped long term care facilities, other hospitals, county departments of health, cities and businesses ensure that their patients and sta� were safe during the pandemic. Overall, we tested well over 200,000 patients and provided results in less than 48 hours 99.9% of the time.

The pandemic has provided new opportunities for growth. More ambulatory patients being seen via telemedicine and in clinics results in more laboratory testing being ordered. This ambulatory growth contributed significantly to our growth this past year (10%). We experienced 5% growth in inpatient lab testing. We became a designated laboratory provider for State Employees which accounted for 1% growth; and our COVID testing helped us grow an additional 4%. This totals a 20% billed test volume increase for the fiscal year.

Since FY2018, the lab has grown at an average year-over-year (YOY) rate of 10%. Likewise, outpatient testing has increased at an even greater rate, YOY.

WELCOME NEW STAFFTamara Osborn, Fellowship and Graduate Studies Coordinator, will support the Cytopathology, Hematopathology and Selective (Surgical) Fellowship programs and the graduate student and undergraduate programs of the department. Tamara worked for several years in KUMC’s GME o�ce where she helped launch the residency management software, MedHub.

Ashley Nichols, O�ce Coordinator, will provide administrative support for faculty recruitment and support the Vice Chair of Research and Faculty Development. She will also be the liaison for UKP HR, University HR, Medical Sta� A�airs and University and Health System IT. Ashley joins us from Children’s Mercy Hospital.

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Soumen Paul, Ph.D. Professor with TenureDirector, Pathology Graduate Studies ProgramDirector, Center for Perinatal Research

NEWEST ALUMNI: 2021 GRADUATES

The 2021 PGY4 Resident and Fellows Graduation and Awards took place via Zoom on Sunday, May 23, 2021. Congratulations, graduates!

AP/CP RESIDENCYKATIE DENNIS, M.D., PROGRAM DIRECTOR SHARAD MATHUR, M.D., ASSOCIATE PROGRAM DIRECTORJAIME PORTER, M.D., ASSOCIATE PROGRAM DIRECTOR

Keenan Hogan, M.D.Cytopathology Fellowship University of Kansas Medical Center, Kansas City, KS

Irfan Khan, M.D.Oncologic Surgical Pathology Fellowship Memorial Sloan Kettering New York, NY

Raquele Laury, M.D.Cytopathology Fellowship University of Kansas Medical Center Kansas City, KS

Azhar Saeed, M.D.Molecular Pathology Fellowship University of MinnesotaMinneapolis, MN

Rakesh Sethapati, MBBSHematopathology Fellowship City of Hope, Los Angeles, CA 

CYTOPATHOLOGY FELLOWSHIPKATIE DENNIS, M.D., PROGRAM DIRECTOR SARAH KELTING, M.D., ASSOCIATE PROGRAM DIRECTOR

Karsten Evans, M.D.Hematopathology Fellowship University of Kansas Medical Center Kansas City, KS

Shane Weindel, M.D.Hematopathology Fellowship University of Arkansas Little Rock, AR

HEMATOPATHOLOGY FELLOWSHIPDA ZHANG, M.D., M.S., PROGRAM DIRECTOR

Regina Plummer, D.O.Methodist Pathology Center

Omaha, NE

SURGICAL PATHOLOGY FELLOWSHIPRASHNA MADAN, MBBS, PROGRAM DIRECTOR

Ethar Al-Husseinawi, MBChB, Ph.D. LabCorp-Kansas City Overland Park, KS

POST-SOPHOMORE FELLOWSHIPRASHNA MADAN, MBBS, PROGRAM DIRECTOR

Daniel Kong Kansas City University of Medicine and Biosciences Kansas City, MO

Payal Patel Kansas City University of Medicine and Biosciences Kansas City, MO

Read more at: kumc.edu/school-of-medicine/pathology/news.html

ALUMNI NEWS

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CURRENT TRAINEES

PATHOLOGY AND LABORATORY MEDICINE RESIDENTS, FELLOWS AND PSFS, 2021-2022

Welcome PGY1s and PSFs!Maryam Abdo, MBChB PGY1

George Kostanian, M.D. PGY2

Issa Al-kharouf, M.D. PGY1

Priscilla Quach, D.O. PGY2

Sarah Cain, D.O. PGY1

Hanan Elsarraj, MBBCh PGY2

Angela France, D.O. PGY3

Janna Shold, D.O. PGY3

Molly Walkenhorst, D.O. PGY1

Robert Hoyt, M.D. PGY2

Chris Jurief, D.O. PGY3

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For more information on current residents, fellows, and post-sophomore fellows visit: kumc.edu/school-of-medicine/pathology.html

Josh Smith, D.O. PGY3

Keenan Hogan, M.D. PGY5CYTOPATHOLOGY FELLOW

Linlin Gao, MBBS PGY4

Raquele Laury, M.D. PGY5CYTOPATHOLOGY FELLOW

Michaela O’Connor POST-SOPHOMORE FELLOW

Natalie Tupper POST-SOPHOMORE FELLOW

Brent Harbaugh, D.O. PGY4

Andrew Ly, D.O. PGY4

Paul McGowan, D.O. PGY4

Anna Heimes Dillon, M.D. PGY4

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Clay Jarrell, M.D. PGY5SURGICAL PATHOLOGY FELLOW

Karsten Evans, M.D. PGY6HEMEPATHOLOGY FELLOW

RESEARCH & SCHOLARLY ACTIVITIES

RECENT GRANTS

KHURSHEED IQBAL, PH.D., MICHAEL SOARES, PH.D & JAY L. VIVIAN, PH.D.A New Animal Model For Investigating the Invasive Trophoblast LineageNIH; $438,874 annually; 7/1/21–6/30/23

SOUMEN PAUL, PH.D.Histone Demethylases and Trophoblast Di�erentiationNIH; Eunice Kennedy Shriver National Institute of Child Health & Human Development; $231,000 annually; 7/1/21–6/30/23

Modeling Human Placentation via Single Cell RNA-Sequencing NIH; Eunice Kennedy Shriver National Institute of Child Health & Human Development; $428,156 annually; 8/1/21–7/31/26

M.A. KARIM RUMI, MBBS, PH.D.Oocyte Stage-Specific Role of Erβ In Primordial Follicle ActivationNIH; $425,005 annually; 9/1/21–8/31/23

REGAN SCOTT, M.S. & MICHAEL SOARES, PH.D.Establishment of the Uterine-Placental Interface NIH; $173,191 annually; 7/1/21–6/30/26

KEY PRESENTATIONS

ANDREW K. GODWIN, PH.D.Romidepsin (HDACi) Plus Cisplatin and Nivolumab Triplet Combination In Patients with Metastatic Triple Negative Breast Cancer mTNBC) Sharma P, et al. Abstract-ASCO Session Breast Cancer–Metastatic, June 4th – 8th, 2021. Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021) 1076-1076. (Virtual)

FRED V. PLAPP, M.D., PH.D.SARS-CoV-2 and the COVID-19 Pandemic: An overviewKeynote Presentation. Disease Control and Prevention Summit - America. July 20, 2021 (Virtual)

X. LONG ZHENG, M.D., PH.D.AJMC Insights: Management of Acquired Thrombotic Thrombocytopenic Purpura Interview with AJMC Managed Markets Network aired, July 22, 2021 - 2:00-3:00pm ET. Recorded video interview that was broken into small pieces and edited for airing. Target Audience: Hospital physicians and administrators, and health care policy makers. ajmc.com/view/diagnostic-approach-to-acquired-ttp

Melanoma Triggers Severe Thrombotic Thrombocytopenic Purpura and Results in a High Mortality Rate in adamt13-/- ZebrafishZheng L. Cao L. Zheng XL. Abstract Number: PB0836. Res Pract Thromb Haemost. 2021; 5 (Suppl 1). ISTH 2021 Congress. July 17-21, 2021. (Virtual)

Low Plasma ADAMTS13 Activity Contributes to Increased Mortality Rate in Hospitalized Patients with Suspected Heparin-induced ThrombocytopeniaChan M. Zheng XL. Abstract Number: PB0839. Res Pract Thromb Haemost. 2021; 5 (Suppl 1) ISTH 2021 Congress. July 17-21, 2021. (Virtual)

GME RESEARCH FORUM 2021

KEENAN HOGAN, M.D.- 1ST PLACE RESIDENT POSTERCompliance With STARD 2015 Recommendations in PathologyPoster with Voiceover. KU Medical Center, Kansas City, KS. May 2021 (Virtual)

KARSTEN EVANS, M.D. - 2ND PLACE FELLOW POSTERComparison of Endoscopic Ultrasound-Guided Fine Needle Sampling Methods for Obtaining Adequate Material for Diagnosis and Mismatch Repair Protein Testing of Pancreatic Adenocarcinoma Poster with Voiceover. KU Medical Center, Kansas City, KS. May 2021 (Virtual)

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RECENT PUBLICATIONS

TODD BRADLEY, M.D.Humoral Immune Responses During SARS-CoV-2 mRNA Vaccine Administration in Seropositive and Seronegative IndividualsFraley E, et al. BMC Med. 2021 Jul 26;19(1):169. doi: 10.1186/s12916-021-02055-9. PMID: 34304742; PMCID: PMC8310732.

Immune Cell Residency in the Nasal Mucosa May Partially Explain Respiratory Disease Severity Across the Age RangeWinkley K, et al. Sci Rep. 2021 Aug 5;11(1):15927. doi: 10.1038/s41598-021-95532-3. PMID: 34354210; PMCID: PMC8342554.

Cross-Reactive Antibody Immunity Against SARS-CoV-2 in Children and AdultsFraley E, et al. Cell Mol Immunol. 2021 Jul;18(7):1826-1828. doi: 10.1038/s41423-021-00700-0. Epub 2021 May 31. PMID: 34059791; PMCID: PMC8165340.

NIKKI CHENG, PH.D.Self-Assembling Peptide Solution Accelerates HemostasisCarter T, et al. Adv Wound Care (New Rochelle). 2021 Apr;10(4):191-203. doi: 10.1089/wound.2019.1109. Epub 2020 Sep 10. PMID: 32716728; PMCID: PMC7906870.

WEI CUI, M.D. & FRED V. PLAPP, M.D., PH.D.Flow Cytometric, Morphologic, and Laboratory Comparative Study In Patients with leukocytosis and Cytopenia Estafani R, Cui W, Plapp F. Int Clin Cyto Soc. 2021. Vol XII, No. 2

MARK CUNNINGHAM, M.D. & FRED V. PLAPP, M.D., PH.D.Acquired Factor V Inhibitor in the Setting of Coronavirus Disease 2019 Infection

Bennett J, et al. Blood Coagul Fibrinolysis. 2021 Jun 1;32(4):294-297. doi: 10.1097/MBC.0000000000001009. PMID: 33443928.

IVAN DAMJANOV, M.D., PH.D. Testicular Germ Cell Tumors: Serological and Immunohistochemical DiagnosisDamjanov I. Acta Med Acad. 2021 Apr;50(1):58-70. doi: 10.5644/ama2006-124.326. PMID: 34075764.

Advances in Diagnostic and Molecular PathologyVranić S, Damjanov I. Acta Med Acad. 2021 Apr;50(1):1-3. doi: 10.5644/ama2006-124.321. PMID: 34075759

KATIE L. DENNIS, M.D. IFT-A Deficiency in Juvenile Mice Impairs Biliary Development and Exacerbates ADPKD Liver DiseaseWang W, et al. J Pathol. 2021 Jul;254(3):289-302. doi: 10.1002/path.5685. Epub 2021 May 21. PMID: 33900625.

PATRICK E. FIELDS, PH.D. The Role of O-GlcNAcylation in Immune Cell Activation

Qiang A, Slawson C, Fields PE. Front Endocrinol (Lausanne). 2021 Apr 27;12:596617. doi: 10.3389/fendo.2021.596617. PMID: 33986724; PMCID: PMC8112354.

TIMOTHY FIELDS,M.D., PH.D. & DA ZHANG, M.D., MS.C.Posttransplant Proteinuria Due to Apolipoprotein E2 Deposition in a Kidney AllograftRamakrishnan M, et al. Am J Transplant. 2021 Jul 30. doi: 10.1111/ajt.16774. Epub ahead of print. PMID: 34327815.

GARTH R. FRAGA, M.D.Giant Congenital Blue Nevus Presenting as Cutis Verticis Gyrata: A Case Report and Review of the Literature

Cullom ME, et al. Ann Otol Rhinol Laryngol. 2021 Apr 3:34894211007236. doi: 10.1177/00034894211007236. Epub ahead of print. PMID: 33813872.

GARTH R. FRAGA, M.D. & HONGYAN DAI, M.D.Trichilemmal Cysts with Divergent Ductal Differentiation: A Series of 4 CasesKhan I, Fraga GR, Dai H, et al. Am J Dermatopathol. 2021 Jul 1;43(7):493-496. doi: 10.1097/DAD.0000000000001839. PMID: 33201018.

GARTH R. FRAGA, M.D., FARIBA BEHBOD, PHARM.D., PH.D. & NIKKI CHENG, PH.D.Expression of CCL2/CCR2 Signaling Proteins in Breast Carcinoma Cells Is Associated with Invasive ProgressionFang WB, et al. Sci Rep. 2021 Apr 22;11(1):8708. doi: 10.1038/s41598-021-88229-0. PMID: 33888841; PMCID: PMC8062684.

ELIZABETH J. FRIEDMAN, M.D.Microsurgical Management of Early Onset Alveolar Soft Part Sarcoma of the Oral Tongue: Case Report and Review of the LiteratureLucas JC, et al. Ann Otol Rhinol Laryngol. 2021 May 28:34894211021261. doi: 10.1177/00034894211021261. Epub ahead of print. PMID: 34044611.

ANDREW K. GODWIN, PH.D. Breast and Prostate Cancer Risks For Male BRCA1 and BRCA2 Pathogenic Variant Carriers Using Polygenic Risk Scores

Barnes DR, et al. J Natl Cancer Inst. 2021 Jul 28:djab147. doi: 10.1093/jnci/djab147. Epub ahead of print. PMID: 34320204.

Entinostat, a Selective HDAC1/2 Inhibitor, Potentiates the Effects of Olaparib In Homologous Recombination Proficient Ovarian Cancer

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Gupta VG, et al. Gynecol Oncol. 2021 Jul;162(1):163-172. doi: 10.1016/j.ygyno.2021.04.015. Epub 2021 Apr 16. PMID: 33867143.

A Framework for Personalized Mammogram ScreeningPal Mudaranthakam D, et al. Prev Med Rep. 2021 Jun 10;23:101446. doi: 10.1016/j.pmedr.2021.101446. PMID: 34168953; PMCID: PMC8209666.

The Predictive Ability of the 313 Variant-Based Polygenic Risk Score for Contralateral Breast Cancer Risk Prediction in Women of European Ancestry with a Heterozygous BRCA1 or BRCA2 Pathogenic VariantLakeman, IMM et al. Genet Med. 2021 Jun 10. doi: 10.1038/s41436-021-01198-7. Epub ahead of print. PMID: 34113011

Author Correction: A Case-Only Study to Identify Genetic Modifiers of Breast Cancer Risk for BRCA1/BRCA2 Mutation CarriersCoignard, J et al. Nat Commun. 2021 May 14;12(1):2986. doi: 10.1038/s41467-021-23162-4. Erratum for: Nat Commun. 2021 Feb 17;12(1):1078. PMID: 33990587; PMCID: PMC8121813.

ANDREW K. GODWIN, PH.D. & HARSH B. PATHAK, PH.D.Exploration of Biomarkers from a Pilot Weight Management Study for Men Undergoing Radical ProstatectomyDimachkie MD, et al. Urol Oncol. 2021 Aug;39(8):495.e7-495.e15. doi: 10.1016/j.urolonc.2021.01.010. Epub 2021 Feb 7. PMID: 33563536.

AMEER HAMZA, M.D.Metastasis from Tongue Squamous Cell Carcinoma to the KidneyElsarraj HS, Khawar S, Hamza A. Autops Case Rep. 2021 Mar12;11:e2021257. doi: 10.4322/acr.2021.257. PMID: 34307220;PMCID: PMC8214874.

New Certification Requirement For Autopsies: Few Things to ConsiderHamza A. Autops Case Rep. 2021 Jan 28;11:e2020229. doi: 10.4322/acr.2020.229. PMID: 33968817; PMCID: PMC8020584.

KHURSHEED IQBAL, PH.D. & MICHAEL J. SOARES, PH.D.The Aryl Hydrocarbon Receptor Mediates Reproductive Toxicity of Polychlorinated Biphenyl Congener 126 in RatsKlenov V, et al. Toxicol Appl Pharmacol. 2021 Sep 1;426:115639. doi: 10.1016/j.taap.2021.115639. Epub 2021 Jul 10. PMID: 34256052.

SUV39H2 Controls Trophoblast Stem Cell FateWang L, et al. Biochim Biophys Acta Gen Subj. 2021 Jun;1865(6):129867. doi: 10.1016/j.bbagen.2021.129867. Epub 2021 Feb 5. PMID: 33556426; PMCID: PMC8052280.

ROY A. JENSEN, M.D.Precision Therapy with Anaplastic Lymphoma Kinase Inhibitor Ceritinib in ALK-Rearranged Anaplastic Large Cell LymphomaSubbiah V et al. ESMO Open. 2021 Jul 6;6(4):100172. doi: 10.1016/j.esmoop.2021.100172. Epub ahead of print. PMID: 34242968; PMCID: PMC8271116.

Honokiol A�ects Stem Cell Viability By Suppressing Oncogenic YAP1 Function to Inhibit Colon TumorigenesisSubramaniam D, et al. Cells. 2021 Jun 26;10(7):1607. doi: 10.3390/cells10071607. PMID: 34206989; PMCID: PMC8303768.

The Trans-Ancestral Genomic Architecture of Glycemic TraitsChen J, et al. Nat Genet. 2021 Jun;53(6):840-860. doi: 10.1038/s41588-021-00852-9. Epub 2021 May 31. PMID: 34059833; PMCID: PMC7610958.

Fosciclopirox Suppresses Growth of High-Grade Urothelial Cancer by Targeting the γ-secretase ComplexWeir SJ, et al. Cell Death Dis. 2021 May 31;12(6):562. doi: 10.1038/s41419-021-03836-z. PMID: 34059639; PMCID: PMC8166826

Preclinical Evaluation of Gilteritinib on NPM1-ALK-Driven Anaplastic Large Cell Lymphoma CellsKuravi S, et al. Mol Cancer Res. 2021 May;19(5):913-920. doi: 10.1158/1541-7786.MCR-20-0738. Epub 2021 Jan 29. PMID: 33514657.

Celastrol and Triptolide Suppress Stemness in Triple Negative Breast Cancer: Notch as a Therapeutic Target for Stem CellsRamamoorthy P, et al. Biomedicines. 2021 Apr 28;9(5):482. doi: 10.3390/biomedicines9050482. PMID: 33924995; PMCID: PMC8146582.

SHARAD C. MATHUR, M.D.Forkhead Box F1 Induces Columnar Phenotype and Epithelial-to-Mesenchymal Transition in Esophageal Squamous Cells to Initiate Barrett’s Like MetaplasiaDe A, et al. Lab Invest. 2021 Jun;101(6):745-759. doi: 10.1038/s41374-021-00534-4. Epub 2021 Jan 25. PMID: 33495575.

JAY E. MENITOVE, M.D., PH.D.Needed Resiliency Improvements for the National Blood SupplyMenitove J, et al. Transfusion. 2021 Jul 30. doi: 10.1111/trf.16611. Epub ahead of print. PMID: 34331331

A Survey of US Hospitals on Platelet Inventory Management, Transfusion Practice, and Platelet AvailabilityPandey S, et al. Transfusion. 2021 Jul 19. doi: 10.1111/trf.16561. Epub ahead of print. PMID: 34287930.

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ANDERS MEYER, M.D.Gene Fusion Identification Using Anchor-Based Multiplex PCR and Next-Generation SequencingCheng YW, et al. J Appl Lab Med. 2021 Jul 7;6(4):917-930. doi: 10.1093/jalm/jfaa230. PMID: 33537766.

Diagnostic Utility of a Custom 34-Gene Anchored MultiplexPCR-Based Next-GenerationSequencing Fusion Panel forthe Diagnosis of Bone andSoft Tissue Neoplasms withIdentification of Novel USP6Fusion Partners in AneurysmalBone CystsDermawan JK, et al. Arch Pathol Lab Med. 2021 Jul 1;145(7):851-863. doi: 10.5858/arpa.2020-0336-OA. PMID: 33147323.

CHRISTOPHE P. NICOT, PH.D.Germinal Epimutation of Fragile Histidine Triad (FHIT) Gene is Associated with Progression to Acute and Chronic Adult T-Cell Leukemia DiseasesBellon M, et al. Mol Cancer. 2021 Jun 6;20(1):86. doi: 10.1186/s12943-021-01370-2. PMID: 34092254; PMCID: PMC8183032.

HARSH B. PATHAK, PH.D. & ANDREW K. GODWIN, PH.D.Clinical and Biomarker Results from Phase I/II Study of PI3K Inhibitor Alpelisib Plus Nab-Paclitaxel in HER2-Negative Metastatic Breast CancerSharma P, et al. Clin Cancer Res. 2021 Jul 15;27(14):3896-3904. doi: 10.1158/1078-0432.CCR-20-4879. Epub 2021 Feb 18. PMID: 33602685; PMCID: PMC8282704.

REGINA PLUMMER, M.D., SARAH KELTING, M.D., RASHNA MADAN, MBBS, MAURA O’NEIL, M.D. & KATIE DENNIS, M.D.Cervical Papanicolaou Tests in the Female-to-Male Transgender Population: Should the Adequacy Criteria Be Revised in This Population? An Institutional ExperiencePlummer RM, et al. J Am Soc Cytopathol. 2021 May-Jun;10(3):255-260. doi: 10.1016/j.jasc.2021.01.004. Epub 2021 Jan 29. PMID: 33736951.

MICHAEL J. SOARES, PH.D.Paradigms for Investigating Invasive Trophoblast Cell Development and Contributions to Uterine Spiral Artery RemodelingVarberg K, Soares MJ. Placenta. 2021 May 3:S0143-4004(21)00130-2. doi: 10.1016/j.placenta.2021.04.012. Epub ahead of print. PMID: 33985793.

MICHAEL P. WASHBURN, PH.D.K63-linked Ubiquitination of DYRK1A by TRAF2 Alleviates Sprouty 2-Mediated Degradation of EGFRZhang P, et al. Cell Death Dis. 2021 Jun 11;12(6):608. doi: 10.1038/s41419-021-03887-2. PMID: 34117217; PMCID:PMC8196033.

JANET WOODROOF, PH.D.Colorectal Adenocarcinoma Presenting with Isolated Metastasis to the Cortical Bone and Bone Marrow: A Case Report and Review of the Literature

Ripp J, Diab O, Woodroof J, Sun W. Clin Colorectal Cancer. 2021 Jun;20(2):e150-e154. doi: 10.1016/j.clcc.2020.12.004. Epub 2021 Jan 5. PMID: 33436305.

X. LONG ZHENG, M.D., PH.D.A Human Monoclonal Antibody Against the Distal Carboxyl Terminus of ADAMTS-13 Modulates Its Susceptibility to an Inhibitor in Thrombotic Thrombocytopenic PurpuraHalkidis K, Siegel DL, Zheng XL. J Thromb Haemost. 2021Aug;19(8):1888-1895. doi: 10.1111/jth.15332. Epub 2021 May 11.PMID: 33834592; PMCID:PMC8324539.

The Standard of Care for Immune Thrombotic Thrombocytopenic Purpura Today Zheng XL. J Thromb Haemost. 2021 Aug;19(8):1864-1871. doi: 10.1111/jth.15406. Epub 2021 Jun 30. PMID: 34060225; PMCID:PMC8324529.

Plasma Levels of Big Endothelin-1 Are Associated with Renal Insu§ciency and In-Hospital Mortality of Immune Thrombotic Thrombocytopenic PurpuraLu R, Zheng XL. Thromb Haemost. 2021 May 13. doi: 10.1055/a-1508-8347. Epub ahead of print. PMID: 33984867.

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DEPARTMENT HIGHLIGHTS

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AUGUST 26, 2021 | TIME 12:00-1:00 PM | ZOOM

Mechanisms of transgenerational inheritance of obesity epiphenotypesVictor G. Corces, PhD, Professor, Department of Human Genetics, Emory University School of Medicine. Atlanta, Georgia

SEPTEMBER 2, 2021 | TIME 12:00-1:00 PM | ZOOM

From Glowing Penis to Oocyte-Producing Testis: Power of Mouse Genetics on Reproductive Biology ResearchHumphrey Yao, PhD, NIH/NIEHS

OCTOBER 21, 2021 | TIME 12:00-1:00 PM | ZOOMMana Parast, MD, PhD, University of California, San Diego

OCTOBER 28, 2021 | TIME 8:30-9:30 AM | WAHL HALL WESTUnderstanding the Impacts of NF1 Loss in breast cancerEric Chang, PhD, Baylor University

NOVEMBER 18, 2021 | TIME 12:00-1:00 PM | ZOOMMortimer Poncz, MD, Children’s Hospital of Philadelphia

DECEMBER 9, 2021 | TIME TBA | ZOOMIVAN DAMJANOV LECTURE IN STEM CELL RESEARCHGenome-Wide Dynamics of Chromatin ModifiersTerry Magnuson, PhD, University of North Carolina

For more information visit: kumc.edu/school-of-medicine/irpr/events/seminar-series

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