Curriculum Vitae

Huan-Xiang Zhou

February 15, 2017

General Information

University address: Physics

College of Arts and Sciences

Kasha Building 419

Florida State University

Tallahassee, Florida 32306-4380

E-mail address: hzhou4@fsu.edu

Web site: http://web2.physics.fsu.edu/~zhou

Professional Preparation

1988 Ph.D., Drexel University. Major: Physics.

1984 B.S., Wuhan University, China. Major: Physics.

Professional Experience

2005–present Professor, Physics, Florida State University.

2002–2005 Associate Professor, Physics, Florida State University.

1998–2002 Associate Professor, Physics, Drexel University.

1995–1998 Assistant Professor, Biochemistry, Hong Kong University of Science and

Technology.

1990–1995 Visiting Associate, Laboratory of Chemical Physics, National Institutes of

Health.

1988–1990 Visiting Fellow, Laboratory of Chemical Physics, National Institutes of

Health.

Honors, Awards, and Prizes

PAI Award for Excellence in Teaching and Research, Department of Physics, Florida State

Vita for Huan-Xiang Zhou

Page 2

University (2016).

Distinguished Research Professor Award, Florida State University (2011).

Elected Fellow Status

Elected as a Fellow of American Physical Society (2010).

Elected as a Fellow of American Association for the Advancement of Science (2008).

Fellowship(s)

Emerson Fellowship, Emory University (1997).

CUSPEA Graduate Fellowship, Drexel University (1984–1988).

Teaching

Courses Taught

Biophysics I (PHZ5715)

Directed Individual Study (MOB5905)

Directed Individual Study (PHY5909)

Thermal and Statistical Physics (PHY4513)

Thermal and Statistical Physics (PHY5515)

Honors Work (PHY4970)

DIS-COMPUT STRUC BIOL (MOB5905)

Directed Individual Study (PHY5904)

DIS-Biophysics Research (MOB5905)

PROTEIN CROWDERS (BSC4900)

Biophysics (PHY5909)

Directed Individual Study (PHY4905)

College Physics A (PHY2053)

College Physics A (PHY2053C)

General Physics A (PHY2048C)

General Physics A (PHY2048)

Intermediate Mechanics (PHY3221)

Special Topics in Physics (PHY6938)

General Physics Lab (PHY2048)

General Physics Lab (PHY2048L)

Doctoral Committee Chair

Batra, J., graduate. (2009).

Tjong, H., graduate. (2008).

Vita for Huan-Xiang Zhou

Page 3

Yi, M., graduate. (2008).

Alsallaq, R. A., graduate. (2007).

Nguemaha, V. M., doctoral candidate.

Banks, A. J., doctoral student.

Ghosh, A., doctoral student.

Hicks, A., doctoral student.

Mazarakos, K., doctoral student.

Doctoral Committee Cochair

Noble, A. J., graduate. (2016).

Daneshparvar, N., doctoral student.

Doctoral Committee Member

Lowry, T. W., graduate. (2016).

Bingol, A. K., graduate. (2013).

Ruben, E. A., graduate. (2007).

Aitchison, E. W., doctoral candidate.

Amouzandeh, G., doctoral candidate.

Doctoral Committee University Representative

Sharma, M., graduate. (2010).

Bhattacharya, N., graduate. (2007).

Master's Committee Member

Groat, B. B. R., graduate. (2016).

Bachelor's Committee Chair

Megan, M., graduate. (2015).

Sumpter, M., graduate. (2013).

Research and Original Creative Work

Program of Research and/or Focus of Original Creative Work

Quantitative understanding of biological processes in the cellular context, based on physical

Vita for Huan-Xiang Zhou

Page 4

principles. (1) Kinetics and mechanism of protein association; (3) Crowding and confinement

effects in cellular environments; (3) Structure and function of ion channels and other membrane

proteins; and (4) Structures and mechanisms of peptide self-assembly.

Publications

Refereed Journal Articles

Pang, X., & Zhou, H. X. (in press). Rate constants and mechanisms of protein-ligand binding.

Annu. Rev. Biophys.

Zhou, H. X. (in press). Gating motions and stationary gating properties of ionotropic glutamate

receptors: computation meets electrophysiology. Acc. Chem. Res.

Zhou, H. X., & Wollmuth, L. P. (in press). Advancing NMDA receptor physiology by

integrating multiple approaches. Trends Neurosci.

Qin, S., & Zhou, H. X. (2017). Protein folding, binding, and droplet formation in cell-like

conditions. Curr. Opin. Struct. Biol, 43, 28-37. doi:10.1016/j.sbi.2016.10.006

Batra, J., Tjong, H., & Zhou, H. X. (2016). Electrostatic effects on the folding stability of

FKBP12. Protein Eng Des Sel, 29(8), 301-8. Retrieved from

http://www.ncbi.nlm.nih.gov/pubmed/27381026 doi:10.1093/protein/gzw014

Dai, J., & Zhou, H. X. (2016). Semiclosed conformations of the ligand-binding domains of

NMDA receptors during stationary gating. Biophys. J, in press.

Gan, Q., Dai, J., Zhou, H. X., & Wollmuth, L. P. (2016). The Transmembrane Domain Mediates

Tetramerization of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid

(AMPA) Receptors. J Biol Chem, 291(12), 6595-606. Retrieved from

http://www.ncbi.nlm.nih.gov/pubmed/26839312 doi:10.1074/jbc.M115.686246

Guo, C., & Zhou, H. X. (2016). Unidirectional allostery in the regulatory subunit RIα facilitates

efficient deactivation of protein kinase A. Proc Natl Acad Sci U S A, in press.

Guo, J., & Zhou, H. X. (2016). Allosteric activation of SENP1 by SUMO1 beta-grasp domain

involves a dock-and-coalesce mechanism. Elife, 5, e18249. Retrieved from

http://www.ncbi.nlm.nih.gov/pubmed/27576863 doi:10.7554/eLife.18249

Guo, J., & Zhou, H. X. (2016). Protein Allostery and Conformational Dynamics. Chem Rev,

116(11), 6503-15. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/26876046

doi:10.1021/acs.chemrev.5b00590

Vita for Huan-Xiang Zhou

Page 5

Im, W., Liang, J., Olson, A., Zhou, H. X., Vajda, S., & Vakser, I. A. (2016). Challenges in

structural approaches to cell modeling. J Mol Biol, 428(15), 2943-64. Retrieved from

http://www.ncbi.nlm.nih.gov/pubmed/27255863 doi:10.1016/j.jmb.2016.05.024

Lensink, M. F., Velankar, S., Kryshtafovych, A., Huang, S. Y., Schneidman-Duhovny, D., Sali,

A., Segura, J., Fernandez-Fuentes, N., Viswanath, S., Elber, R., Grudinin, S., Popov, P.,

Neveu, E., Lee, H., Baek, M., Park, S., Heo, L., Rie Lee, G., Seok, C., Qin, S., Zhou, H.

X., Ritchie, D. W., Maigret, B., Devignes, M. D., Ghoorah, A., Torchala, M., Chaleil, R.

A., Bates, P. A., Ben-Zeev, E., Eisenstein, M., Negi, S. S., Weng, Z., Vreven, T., Pierce,

B. G., Borrman, T. M., Yu, J., Ochsenbein, F., Guerois, R., Vangone, A., Rodrigues, J.

P., van Zundert, G., Nellen, M., Xue, L., Karaca, E., Melquiond, A. S., Visscher, K.,

Kastritis, P. L., Bonvin, A. M., Xu, X., Qiu, L., Yan, C., Li, J., Ma, Z., Cheng, J., Zou,

X., Shen, Y., Peterson, L. X., Kim, H. R., Roy, A., Han, X., Esquivel-Rodriguez, J.,

Kihara, D., Yu, X., Bruce, N. J., Fuller, J. C., et. al. (2016). Prediction of homoprotein

and heteroprotein complexes by protein docking and template-based modeling: A

CASP-CAPRI experiment. Proteins, 84 Suppl 1, 323-48. Retrieved from

http://www.ncbi.nlm.nih.gov/pubmed/27122118 doi:10.1002/prot.25007

Pang, X., & Zhou, H. X. (2016). Mechanism and rate constants of the Cdc42 GTPase binding

with intrinsically disordered effectors. Proteins, 84(5), 674-85. Retrieved from

http://www.ncbi.nlm.nih.gov/pubmed/26879470 doi:10.1002/prot.25018

Qin, S., & Zhou, H. X. (2016). Fast Method for Computing Chemical Potentials and

Liquid-Liquid Phase Equilibria of Macromolecular Solutions. J Phys Chem B, 120(33),

8164-74. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/27327881

doi:10.1021/acs.jpcb.6b01607

Wright, A. K., Batsomboon, P., Dai, J., Hung, I., Zhou, H. X., Dudley, G. B., & Cross, T. A.

(2016). Differential Binding of Rimantadine Enantiomers to Influenza A M2 Proton

Channel. J Am Chem Soc, 138(5), 1506-9. Retrieved from

http://www.ncbi.nlm.nih.gov/pubmed/26804976 doi:10.1021/jacs.5b13129

Dai, J., Wollmuth, L. P., & Zhou, H. X. (2015). Mechanism-Based Mathematical Model for

Gating of Ionotropic Glutamate Receptors. J Phys Chem B, 119(34), 10934-40. Retrieved

from http://www.ncbi.nlm.nih.gov/pubmed/25793415 doi:10.1021/acs.jpcb.5b00521

Dai, J., & Zhou, H. X. (2015). Reduced curvature of ligand-binding domain free-energy surface

underlies partial agonism at NMDA receptors. Structure, 23(1), 228-36.

doi:10.1016/j.str.2014.11.012

Das, N., Dai, J., Hung, I., Rajagopalan, M. R., Zhou, H. X., & Cross, T. A. (2015). Structure of

CrgA, a cell division structural and regulatory protein from Mycobacterium tuberculosis,

in lipid bilayers. Proc Natl Acad Sci U S A, 112(2), E119-26.

doi:10.1073/pnas.1415908112

Vita for Huan-Xiang Zhou

Page 6

Guo, J., Pang, X., & Zhou, H. X. (2015). Two pathways mediate interdomain allosteric

regulation in pin1. Structure, 23(1), 237-47. doi:10.1016/j.str.2014.11.009

Guo, J., & Zhou, H. X. (2015). Dynamically Driven Protein Allostery Exhibits Disparate

Responses for Fast and Slow Motions. Biophys J, 108(12), 2771-4.

doi:10.1016/j.bpj.2015.04.035

Miao, Y., Fu, R., Zhou, H. X., & Cross, T. A. (2015). Dynamic Short Hydrogen Bonds in

Histidine Tetrad of Full-Length M2 Proton Channel Reveal Tetrameric Structural

Heterogeneity and Functional Mechanism. Structure, 23(12), 2300-8. Retrieved from

http://www.ncbi.nlm.nih.gov/pubmed/26526851 doi:10.1016/j.str.2015.09.011

Pang, X., & Zhou, H. X. (2015). Disorder-to-Order Transition of an Active-Site Loop Mediates

the Allosteric Activation of Sortase A. Biophys J, 109(8), 1706-15. Retrieved from

http://www.ncbi.nlm.nih.gov/pubmed/26488662 doi:10.1016/j.bpj.2015.08.039

Berezhkovskii, A. M., Szabo, A., Greives, N., & Zhou, H. X. (2014). Multidimensional reaction

rate theory with anisotropic diffusion. J Chem Phys, 141(20), 204106.

doi:10.1063/1.4902243

Dai, J., & Zhou, H. X. (2014). General rules for the arrangements and gating motions of

pore-lining helices in homomeric ion channels. Nat Commun, 5, 4641.

doi:10.1038/ncomms5641

Greives, N., & Zhou, H. X. (2014). Both protein dynamics and ligand concentration can shift the

binding mechanism between conformational selection and induced fit. Proc Natl Acad

Sci U S A, 111(28), 10197-202. doi:10.1073/pnas.1407545111

Jean-Francois, F. L., Dai, J., Yu, L., Myrick, A., Rubin, E., Fajer, P. G., Song, L., Zhou, H. X., &

Cross, T. A. (2014). Binding of MgtR, a Salmonella transmembrane regulatory peptide,

to MgtC, a Mycobacterium tuberculosis virulence factor: a structural study. J Mol Biol,

426(2), 436-46. doi:10.1016/j.jmb.2013.10.014

Kazi, R., Dai, J., Sweeney, C., Zhou, H. X., & Wollmuth, L. P. (2014). Mechanical coupling

maintains the fidelity of NMDA receptor-mediated currents. Nat Neurosci, 17(7), 914-22.

doi:10.1038/nn.3724

Lensink, M. F., Moal, I. H., Bates, P. A., Kastritis, P. L., Melquiond, A. S., Karaca, E., Schmitz,

C., van Dijk, M., Bonvin, A. M., Eisenstein, M., Jimenez-Garcia, B., Grosdidier, S.,

Solernou, A., Perez-Cano, L., Pallara, C., Fernandez-Recio, J., Xu, J., Muthu, P.,

Praneeth Kilambi, K., Gray, J. J., Grudinin, S., Derevyanko, G., Mitchell, J. C., Wieting,

J., Kanamori, E., Tsuchiya, Y., Murakami, Y., Sarmiento, J., Standley, D. M., Shirota,

M., Kinoshita, K., Nakamura, H., Chavent, M., Ritchie, D. W., Park, H., Ko, J., Lee, H.,

Seok, C., Shen, Y., Kozakov, D., Vajda, S., Kundrotas, P. J., Vakser, I. A., Pierce, B. G.,

Hwang, H., Vreven, T., Weng, Z., Buch, I., Farkash, E., Wolfson, H. J., Zacharias, M.,

Qin, S., Zhou, H. X., Huang, S. Y., Zou, X., Wojdyla, J. A., Kleanthous, C., & Wodak, S.

Vita for Huan-Xiang Zhou

Page 7

J. (2014). Blind prediction of interfacial water positions in CAPRI. Proteins, 82(4),

620-32. doi:10.1002/prot.24439

Pang, X., & Zhou, H. X. (2014). Design rules for selective binding of nuclear localization signals

to minor site of importin alpha. PLoS One, 9(3), e91025.

doi:10.1371/journal.pone.0091025

Pang, X., & Zhou, H. X. (2014). Distinct mechanisms of a phosphotyrosyl peptide binding to

two SH2 domains. J Theor Comput Chem, 13(3), 1440003. doi:PMC4230710

Qin, S., & Zhou, H. X. (2014). Further Development of the FFT-based Method for Atomistic

Modeling of Protein Folding and Binding under Crowding: Optimization of Accuracy

and Speed. J Chem Theory Comput, 10(7), 2824-2835. doi:10.1021/ct5001878

Zhou, H. X. (2014). Theoretical frameworks for multiscale modeling and simulation. Curr Opin

Struct Biol, 25, 67-76. doi:10.1016/j.sbi.2014.01.004

Zhou, H. X., & Bilsel, O. (2014). SAXS/SANS probe of intermolecular interactions in

concentrated protein solutions. Biophys J, 106(4), 771-3. doi:10.1016/j.bpj.2014.01.019

Cormier, A. R., Pang, X., Zimmerman, M. I., Zhou, H. X., & Paravastu, A. K. (2013). Molecular

structure of RADA16-I designer self-assembling peptide nanofibers. ACS Nano, 7(9),

7562-72. doi:10.1021/nn401562f

Dai, J., & Zhou, Huan-Xiang. (2013). An NMDA Receptor Gating Mechanism Developed from

MD Simulations Reveals Molecular Details Underlying Subunit-Specific Contributions.

BIOPHYSICAL JOURNAL, 104(10), 2170-2181. doi:10.1016/j.bpj.2013.04.013

Dong, H., Yi, M., Cross, T. A., & Zhou, H. X. (2013). Ab initio calculations and validation of

the pH-dependent structures of the His37-Trp41 quartet, the heart of acid activation and

proton conductance in the M2 protein of Influenza A virus. Chem Sci, 4(7), 2776-2787.

doi:10.1039/c3sc50293g

Heymann, G., Dai, J., Li, M., Silberberg, S. D., Zhou, H. X., & Swartz, K. J. (2013). Inter- and

intrasubunit interactions between transmembrane helices in the open state of P2X

receptor channels. Proc Natl Acad Sci U S A, 110(42), E4045-54.

doi:10.1073/pnas.1311071110

Leonard, S. R., Cormier, A. R., Pang, X., Zimmerman, M. I., Zhou, H. X., & Paravastu, A. K.

(2013). Solid-state NMR evidence for beta-hairpin structure within MAX8 designer

peptide nanofibers. Biophys J, 105(1), 222-30. doi:10.1016/j.bpj.2013.05.047

Miklos, A. C., Sumpter, M., & Zhou, H. X. (2013). Competitive interactions of ligands and

macromolecular crowders with maltose binding protein. PLoS One, 8(10), e74969.

doi:10.1371/journal.pone.0074969

Vita for Huan-Xiang Zhou

Page 8

Moretti, R., Fleishman, S. J., Agius, R., Torchala, M., Bates, P. A., Kastritis, P. L., Rodrigues, J.

P., Trellet, M., Bonvin, A. M., Cui, M., Rooman, M., Gillis, D., Dehouck, Y., Moal, I.,

Romero-Durana, M., Perez-Cano, L., Pallara, C., Jimenez, B., Fernandez-Recio, J.,

Flores, S., Pacella, M., Praneeth Kilambi, K., Gray, J. J., Popov, P., Grudinin, S.,

Esquivel-Rodriguez, J., Kihara, D., Zhao, N., Korkin, D., Zhu, X., Demerdash, O. N.,

Mitchell, J. C., Kanamori, E., Tsuchiya, Y., Nakamura, H., Lee, H., Park, H., Seok, C.,

Sarmiento, J., Liang, S., Teraguchi, S., Standley, D. M., Shimoyama, H., Terashi, G.,

Takeda-Shitaka, M., Iwadate, M., Umeyama, H., Beglov, D., Hall, D. R., Kozakov, D.,

Vajda, S., Pierce, B. G., Hwang, H., Vreven, T., Weng, Z., Huang, Y., Li, H., Yang, X.,

Ji, X., Liu, S., Xiao, Y., Zacharias, M., Qin, S., Zhou, H. X., et. al. (2013).

Community-wide evaluation of methods for predicting the effect of mutations on

protein-protein interactions. Proteins, 81(11), 1980-7. doi:10.1002/prot.24356

Pang, X., & Zhou, Huan-Xiang. (2013). Activation of signaling receptors: do ligands bind to

receptor monomer, dimer, or both? BMC BIOPHYSICS, 6, 1-3.

doi:10.1186/2046-1682-6-7

Pang, X., & Zhou, Huan-Xiang. (2013). Poisson-Boltzmann Calculations: van der Waals or

Molecular Surface? COMMUNICATIONS IN COMPUTATIONAL PHYSICS, 13(1), 1-12.

doi:10.4208/cicp.270711.140911s

Qin, S., Mittal, J., & Zhou, H. X. (2013). Folding free energy surfaces of three small proteins

under crowding: validation of the postprocessing method by direct simulation. Phys Biol,

10(4), 045001. doi:10.1088/1478-3975/10/4/045001

Qin, S., & Zhou, H. X. (2013). Effects of Macromolecular Crowding on the Conformational

Ensembles of Disordered Proteins. J Phys Chem Lett, 4(20), 3429-3434.

doi:10.1021/jz401817x

Qin, S., & Zhou, H. X. (2013). FFT-based method for modeling protein folding and binding

under crowding: benchmarking on ellipsoidal and all-atom crowders. J Chem Theory

Comput, 9(10), 4633-4643. doi:10.1021/ct4005195

Qin, S., & Zhou, H. X. (2013). PI2PE: A Suite of Web Servers for Predictions Ranging From

Protein Structure to Binding Kinetics. Biophys Rev, 5(1), 41-46.

doi:10.1007/s12551-012-0086-7

Qin, S., & Zhou, H. X. (2013). Using the concept of transient complex for affinity predictions in

CAPRI rounds 20-27 and beyond. Proteins, 81(12), 2229-36. doi:10.1002/prot.24366

Zhou, H. X., & Bates, P. A. (2013). Modeling protein association mechanisms and kinetics. Curr

Opin Struct Biol, 23(6), 887-93. doi:10.1016/j.sbi.2013.06.014

Vita for Huan-Xiang Zhou

Page 9

Zhou, H. X., & Cross, T. A. (2013). Influences of membrane mimetic environments on

membrane protein structures. Annu Rev Biophys, 42, 361-92.

doi:10.1146/annurev-biophys-083012-130326

Zhou, H. X., & Qin, S. (2013). Simulation and Modeling of Crowding Effects on the

Thermodynamic and Kinetic Properties of Proteins with Atomic Details. Biophys Rev,

5(2), 207-215. doi:10.1007/s12551-013-0101-7

Zhou, Huan -Xiang. (2013). Influence of crowded cellular environments on protein folding,

binding, and oligomerization: Biological consequences and potentials of atomistic

modeling. FEBS LETTERS, 587(8), 1053-1061. doi:10.1016/j.febslet.2013.01.064

Zhou, Huan-Xiang. (2013). Polymer crowders and protein crowders act similarly on protein

folding stability. FEBS LETTERS, 587(5), 394-397. doi:10.1016/j.febslet.2013.01.030

Zhou, Huan-Xiang, & Cross, T. A. (2013). Modeling the membrane environment has

implications for membrane protein structure and function: Influenza A M2 protein.

PROTEIN SCIENCE, 22(4), 381-394. doi:10.1002/pro.2232

Cross, T. A., Dong, H., Sharma, M., Busath, D. D., & Zhou, Huan-Xiang. (2012). M2 protein

from Influenza A: from multiple structures to biophysical and functional insights.

CURRENT OPINION IN VIROLOGY, 2(2), 128-133. doi:10.1016/j.coviro.2012.01.005

Dong, H., Sharma, M., Zhou, Huan-Xiang, & Cross, T. A. (2012). Glycines: Role in

alpha-Helical Membrane Protein Structures and a Potential Indicator of Native

Conformation. BIOCHEMISTRY, 51(24), 4779-4789. doi:10.1021/bi300090x

Du, J., Cross, T. A., & Zhou, Huan-Xiang. (2012). Recent progress in structure-based

anti-influenza drug design. DRUG DISCOVERY TODAY, 17(19-20), 1111-1120.

doi:10.1016/j.drudis.2012.06.002

Du, J., Dong, H., & Zhou, Huan-Xiang. (2012). Gating mechanism of a P2X4 receptor

developed from normal mode analysis and molecular dynamics simulations.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED

STATES OF AMERICA, 109(11), 4140-4145. doi:10.1073/pnas.1119546109

Du, J., Dong, H., & Zhou, Huan-Xiang. (2012). Size matters in activation/inhibition of

ligand-gated ion channels. TRENDS IN PHARMACOLOGICAL SCIENCES, 33(9),

482-493. doi:10.1016/j.tips.2012.06.005

Greives, N., & Zhou, Huan-Xiang. (2012). BDflex: A method for efficient treatment of

molecular flexibility in calculating protein-ligand binding rate constants from Brownian

dynamics simulations. JOURNAL OF CHEMICAL PHYSICS, 137(13), 135105.

doi:10.1063/1.4756913

Vita for Huan-Xiang Zhou

Page 10

Loong, C. K. P., Zhou, Huan-Xiang, & Chase, P. B. (2012). Familial hypertrophic

cardiomyopathy related E180G mutation increases flexibility of human cardiac

alpha-tropomyosin. FEBS LETTERS, 586(19), 3503-3507.

doi:10.1016/j.febslet.2012.08.005

Loong, C. K. P., Zhou, Huan-Xiang, & Chase, P. B. (2012). Persistence Length of Human

Cardiac alpha-Tropomyosin Measured by Single Molecule Direct Probe Microscopy.

PLOS ONE, 7(6), e39676. doi:10.1371/journal.pone.0039676

Pang, X., & Zhou, Huan-Xiang. (2012). A Common Model for Cytokine Receptor Activation:

Combined Scissor-Like Rotation and Self-Rotation of Receptor Dimer Induced by Class I

Cytokine. PLOS COMPUTATIONAL BIOLOGY, 8(3), e1002427.

doi:10.1371/journal.pcbi.1002427

Pang, X., Zhou, K. H., Qin, S., & Zhou, Huan-Xiang. (2012). Prediction and Dissection of

Widely-Varying Association Rate Constants of Actin-Binding Proteins. PLOS

COMPUTATIONAL BIOLOGY, 8(10), e1002696. doi:10.1371/journal.pcbi.1002696

Phillip, Y., Harel, M., Khait, R., Qin, S., Zhou, Huan-Xiang, & Schreiber, G. (2012). Contrasting

Factors on the Kinetic Path to Protein Complex Formation Diminish the Effects of

Crowding Agents. BIOPHYSICAL JOURNAL, 103(5), 1011-1019.

doi:10.1016/j.bpj.2012.08.009

Qin, S., Cai, L., & Zhou, Huan-Xiang. (2012). A method for computing association rate

constants of atomistically represented proteins under macromolecular crowding.

PHYSICAL BIOLOGY, 9(6), 066008. doi:10.1088/1478-3975/9/6/066008

Szabo, A., & Zhou, Huan-Xiang. (2012). Role of Diffusion in the Kinetics of Reversible

Enzyme-catalyzed Reactions. BULLETIN OF THE KOREAN CHEMICAL SOCIETY,

33(3), 925-928. doi:10.5012/bkcs.2012.33.3.925

Zhou, Huan-Xiang. (2012). Intrinsic disorder: signaling via highly specific but short-lived

association. TRENDS IN BIOCHEMICAL SCIENCES, 37(2), 43-48.

doi:10.1016/j.tibs.2011.11.002

Zhou, Huan-Xiang, Pang, X., & Lu, C. (2012). Rate constants and mechanisms of intrinsically

disordered proteins binding to structured targets. PHYSICAL CHEMISTRY CHEMICAL

PHYSICS, 14(30), 10466-10476. doi:10.1039/c2cp41196b

Barreda, J. L., & Zhou, Huan-Xiang. (2011). A solvable model for the diffusion and reaction of

neurotransmitters in a synaptic junction. BMC BIOPHYSICS, 4, 5.

doi:10.1186/2046-1682-4-5

Vita for Huan-Xiang Zhou

Page 11

Barreda, J. L., & Zhou, Huan-Xiang. (2011). Theory and simulation of diffusion-influenced,

stochastically gated ligand binding to buried sites. JOURNAL OF CHEMICAL PHYSICS,

135(14), 145101. doi:10.1063/1.3645000

Berezhkovskii, A. M., Szabo, A., & Zhou, Huan-Xiang. (2011). Diffusion-influenced ligand

binding to buried sites in macromolecules and transmembrane channels. JOURNAL OF

CHEMICAL PHYSICS, 135(7), 075103. doi:10.1063/1.3609973

Cai, L., & Zhou, Huan-Xiang. (2011). Theory and simulation on the kinetics of protein-ligand

binding coupled to conformational change. JOURNAL OF CHEMICAL PHYSICS,

134(10), 105101. doi:10.1063/1.3561694

Cross, T. A., Sharma, M., Yi, M., & Zhou, Huan-Xiang. (2011). Influence of solubilizing

environments on membrane protein structures. TRENDS IN BIOCHEMICAL SCIENCES,

36(2), 117-125. doi:10.1016/j.tibs.2010.07.005

Dong, H., & Zhou, Huan-Xiang. (2011). Atomistic mechanism for the activation and

desensitization of an AMPA-subtype glutamate receptor. NATURE

COMMUNICATIONS, 2, 354. doi:10.1038/ncomms1362

Fleishman, S. J., Whitehead, T. A., Strauch, Eva-Maria, Corn, J. E., Qin, S., Zhou, Huan-Xiang,

Mitchell, J. C., Demerdash, O. N. A., Takeda-Shitaka, M., Terashi, G., Moal, I. H., Li,

X., Bates, P. A., Zacharias, M., Park, H., Ko, Jun-su, Lee, H., Seok, C., Bourquard, T.,

Bernauer, J., Poupon, A., Aze, J., Soner, S., Ovali, S. K., Ozbek, P., & Ben T. (2011).

Community-Wide Assessment of Protein-Interface Modeling Suggests Improvements to

Design Methodology. JOURNAL OF MOLECULAR BIOLOGY, 414(2), 289-302.

doi:10.1016/j.jmb.2011.09.031

Pang, X., Qin, S., & Zhou, Huan-Xiang. (2011). Rationalizing 5000-Fold Differences in

Receptor-Binding Rate Constants of Four Cytokines. BIOPHYSICAL JOURNAL, 101(5),

1175-1183. doi:10.1016/j.bpj.2011.06.056

Qin, S., Pang, X., & Zhou, Huan-Xiang. (2011). Automated Prediction of Protein Association

Rate Constants. STRUCTURE, 19(12), 1744-1751. doi:10.1016/j.str.2011.10.015

Qin, S., & Zhou, Huan-Xiang. (2011). Structural Models of Protein-DNA Complexes Based on

Interface Prediction and Docking. CURRENT PROTEIN & PEPTIDE SCIENCE, 12(6),

531-539.

Sharma, M., Li, C., Busath, D. D., Zhou, Huan-Xiang, & Cross, T. A. (2011). Drug sensitivity,

drug-resistant mutations, and structures of three conductance domains of viral porins.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1808(2, SI), 538-546.

doi:10.1016/j.bbamem.2010.07.015

Vita for Huan-Xiang Zhou

Page 12

Zhou, Huan-Xiang. (2011). A Theory for the Proton Transport of the Influenza Virus M2

Protein: Extensive Test against Conductance Data. BIOPHYSICAL JOURNAL, 100(4),

912-921. doi:10.1016/j.bpj.2011.01.002

Zhou, Huan-Xiang. (2011). Equivalence of two approaches for modeling ion permeation through

a transmembrane channel with an internal binding site. JOURNAL OF CHEMICAL

PHYSICS, 134(13), 135101. doi:10.1063/1.3575585

Zhou, Huan-Xiang. (2011). Mechanistic Insight into the H2O/D2O Isotope Effect in the Proton

Transport of the Influenza Virus M2 Protein. JOURNAL OF MEMBRANE BIOLOGY,

244(2), 93-96. doi:10.1007/s00232-011-9402-6

Zhou, Huan-Xiang. (2011). Q&A: What is biophysics? BMC BIOLOGY, 9, 13.

doi:10.1186/1741-7007-9

Zhou, Huan-Xiang. (2011). Rapid search for specific sites on DNA through conformational

switch of nonspecifically bound proteins. Proc. Natl. Acad. Sci. USA, 108, 8651-8656.

Bazavov, A., Berg, B. A., & Zhou, Huan-Xiang. (2010). Application of Biased Metropolis

Algorithms: From protons to proteins. MATHEMATICS AND COMPUTERS IN

SIMULATION, 80(6, SI), 1056-1067. doi:10.1016/j.matcom.2009.05.005

Dong, H., Qin, S., & Zhou, Huan-Xiang. (2010). Effects of Macromolecular Crowding on

Protein Conformational Changes. PLOS COMPUTATIONAL BIOLOGY, 6(7), e1000833.

doi:10.1371/journal.pcbi.1000833

Lee, W., Zeng, X., Zhou, Huan-Xiang, Bennett, V., Yang, W., & Marszalek, P. E. (2010). Full

Reconstruction of a Vectorial Protein Folding Pathway by Atomic Force Microscopy and

Molecular Dynamics Simulations. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(49),

38167-38172. doi:10.1074/jbc.M110.179697

Qin, S., Minh, D. D. L., McCammon, J. A., & Zhou, Huan-Xiang. (2010). Method to Predict

Crowding Effects by Postprocessing Molecular Dynamics Trajectories: Application to

the Flap Dynamics of HIV-1 Protease. JOURNAL OF PHYSICAL CHEMISTRY

LETTERS, 1(1), 107-110. doi:10.1021/jz900023w

Qin, S., & Zhou, Huan-Xiang. (2010). Generalized fundamental measure theory for atomistic

modeling of macromolecular crowding. PHYSICAL REVIEW E, 81(3, 1), 031919.

doi:10.1103/PhysRevE.81.031919

Qin, S., & Zhou, Huan-Xiang. (2010). Selection of near-native poses in CAPRI rounds 13-19.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 78(15, SI), 3166-3173.

doi:10.1002/prot.22772

Sharma, M., Yi, M., Dong, H., Qin, H., Peterson, E., Busath, D. D., Zhou, Huan-Xiang, & Cross,

T. A. (2010). Insight into the Mechanism of the Influenza A Proton Channel from a

Vita for Huan-Xiang Zhou

Page 13

Structure in a Lipid Bilayer. SCIENCE, 330(6003), 509-512.

doi:10.1126/science.1191750

Tjong, H., & Zhou, Huan-Xiang. (2010). The Folding Transition-State Ensemble of a Four-Helix

Bundle Protein: Helix Propensity as a Determinant and Macromolecular Crowding as a

Probe. BIOPHYSICAL JOURNAL, 98(10), 2273-2280. doi:10.1016/j.bpj.2010.01.052

Zeng, X., Hu, H., Zhou, Huan-Xiang, Marszalek, P. E., & Yang, W. (2010). Equilibrium

Sampling for Biomolecules under Mechanical Tension. BIOPHYSICAL JOURNAL,

98(4), 733-740. doi:10.1016/j.bpj.2009.11.004

Zhou, Huan-Xiang. (2010). Diffusion-Influenced Transport of Ions across a Transmembrane

Channel with an Internal Binding Site. JOURNAL OF PHYSICAL CHEMISTRY

LETTERS, 1(13), 1973-1976. doi:10.1021/jz1006831

Zhou, Huan-Xiang. (2010). From Induced Fit to Conformational Selection: A Continuum of

Binding Mechanism Controlled by the Timescale of Conformational Transitions.

BIOPHYSICAL JOURNAL, 98(6), L15-L17. doi:10.1016/j.bpj.2009.11.029

Zhou, Huan-Xiang. (2010). Rate theories for biologists. QUARTERLY REVIEWS OF

BIOPHYSICS, 43(2), 219-293. doi:10.1017/S0033583510000120

Zhou, Huan-Xiang. (2010). Speeding up in a crowd. Physics, 3, 77.

Zhou, Huan-Xiang, & McCammon, J. A. (2010). The gates of ion channels and enzymes.

TRENDS IN BIOCHEMICAL SCIENCES, 35(3), 179-185. doi:10.1016/j.tibs.2009.10.007

Batra, J., Xu, K., Qin, S., & Zhou, Huan-Xiang. (2009). Effect of Macromolecular Crowding on

Protein Binding Stability: Modest Stabilization and Significant Biological Consequences.

BIOPHYSICAL JOURNAL, 97(3), 906-911. doi:10.1016/j.bpj.2009.05.032

Batra, J., Xu, K., & Zhou, Huan-Xiang. (2009). Nonadditive effects of mixed crowding on

protein stability. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS,

77(1), 133-138. doi:10.1002/prot.22425

Dong, Guo-Chung, Chuang, Ping-Hsien, Chang, Kai-chun, Jan, Pey-shynan, Hwang, Pei-Ing,

Wu, Huan-Bin, Yi, M., Zhou, Huan-Xiang, & Chen, H. M. (2009). Blocking Effect of an

Immuno-Suppressive Agent, Cynarin, on CD28 of T-Cell Receptor.

PHARMACEUTICAL RESEARCH, 26(2), 375-381. doi:10.1007/s11095-008-9754-5

Maniccia, A. W., Yang, W., Johnson, J. A., Li, S., Tjong, H., Zhou, Huan-Xiang, Shaket, L. A.,

& Yang, J. J. (2009). Inverse tuning of metal binding affinity and protein stability by

altering charged coordination residues in designed calcium binding proteins. PMC

Biophysics, 2, 11.

Vita for Huan-Xiang Zhou

Page 14

Qin, S., & Zhou, Huan-Xiang. (2009). Dissection of the high rate constant for the binding of a

ribotoxin to the ribosome. Proc. Natl. Acad. Sci. USA, 106, 6974-7979.

Qin, S., & Zhou, Huan-Xiang. (2009). Atomistic Modeling of Macromolecular Crowding

Predicts Modest Increases in Protein Folding and Binding Stability. BIOPHYSICAL

JOURNAL, 97(1), 12-19. doi:10.1016/j.bpj.2009.03.066

Schreiber, G., Haran, G., & Zhou, H.-X. (2009). Fundamental Aspects of Protein-Protein

Association Kinetics. CHEMICAL REVIEWS, 109(3), 839-860. doi:10.1021/cr800373w

Yi, M., Cross, T. A., & Zhou, Huan-Xiang. (2009). Conformational heterogeneity of the M2

proton channel and a structural model for channel activation. Proc. Natl. Acad. Sci. USA,

106, 13311 - 13316.

Zhou, Huan-Xiang. (2009). Crowding Effects of Membrane Proteins. JOURNAL OF PHYSICAL

CHEMISTRY B, 113(23), 7995-8005. doi:10.1021/jp8107446

Zhou, Huan-Xiang, & Gilson, M. K. (2009). Theory of Free Energy and Entropy in Noncovalent

Binding. CHEMICAL REVIEWS, 109(9), 4092-4107. doi:10.1021/cr800551w

Alsallaq, R., & Zhou, Huan-Xiang. (2008). Electrostatic rate enhancement and transient complex

of protein-protein association. PROTEINS-STRUCTURE FUNCTION AND

BIOINFORMATICS, 71(1), 320-335. doi:10.1002/prot.21679

Alsallaq, R., & Zhou, Huan-Xiang. (2008). Protein association with circular DNA: Rate

enhancement by nonspecific binding. JOURNAL OF CHEMICAL PHYSICS, 128(11),

115108. doi:10.1063/1.2888996

Li, C., Yi, M., Hu, J., Zhou, Huan-Xiang, & Cross, T. A. (2008). Solid-state NMR and MD

simulations of the antiviral drug amantadine solubilized in DMPC bilayers.

BIOPHYSICAL JOURNAL, 94(4), 1295-1302. doi:10.1529/biophysj.107.112482

Li, S., Yang, W., Maniccia, A. W., Barrow, Jr., Doyle, Tjong, H., Zhou, Huan-Xiang, & Yang, J.

J. (2008). Rational design of a conformation-switchable Ca2+ and Tb3+ binding protein

without the use of multiple coupled metal-binding sites. FEBS JOURNAL, 275(20),

5048-5061. doi:10.1111/j.1742-4658.2008.06638.x

Nymeyer, H., & Zhou, Huan-Xiang. (2008). A method to determine dielectric constants in

nonhomogeneous systems: Application to biological membranes. BIOPHYSICAL

JOURNAL, 94(4), 1185-1193. doi:10.1529/biophysj.107.117770

Qin, S., & Zhou, Huan-Xiang. (2008). Prediction of salt and mutational effects on the association

rate of U1A protein and U1 small nuclear RNA stem/loop II. JOURNAL OF PHYSICAL

CHEMISTRY B, 112(19), 5955-5960. doi:10.1021/jp075919k

Vita for Huan-Xiang Zhou

Page 15

Tjong, H., & Zhou, Huan-Xiang. (2008). Accurate Calculations of Binding, Folding, and

Transfer Free Energies by a Scaled Generalized Born Method. JOURNAL OF

CHEMICAL THEORY AND COMPUTATION, 4(10), 1733-1744. doi:10.1021/ct8001656

Tjong, H., & Zhou, Huan-Xiang. (2008). On the dielectric boundary in Poisson-Boltzmann

calculations. JOURNAL OF CHEMICAL THEORY AND COMPUTATION, 4(3),

507-514. doi:10.1021/ct700319x

Tjong, H., & Zhou, Huan-Xiang. (2008). Prediction of protein solubility from calculation of

transfer free energy. BIOPHYSICAL JOURNAL, 95(6), 2601-2609.

doi:10.1529/biophysj.107.127746

Yang, W., Nymeyer, H., Zhou, Huan-Xiang, Berg, B., & Bruschweiler, R. (2008). Quantitative

computer Simulations of biomolecules: A snapshot. JOURNAL OF COMPUTATIONAL

CHEMISTRY, 29(4), 668-672. doi:10.1002/jcc.20819

Yi, M., Cross, T. A., & Zhou, Huan-Xiang. (2008). A secondary gate as a mechanism for

inhibition of the M2 proton channel by amantadine. JOURNAL OF PHYSICAL

CHEMISTRY B, 112(27), 7977-7979. doi:10.1021/jp800171m

Yi, M., Nymeyer, H., & Zhou, Huan-Xiang. (2008). Test of the Gouy-Chapman theory for a

charged lipid membrane against explicit-solvent molecular dynamics simulations.

PHYSICAL REVIEW LETTERS, 101(3), 038103. doi:10.1103/PhysRevLett.101.038103

Yi, M., Tjing, H., & Zhou, Huan-Xiang. (2008). Spontaneous conformational change and toxin

binding in α7 acetylcholine receptor: insight into channel activation and inhibition. Proc.

Natl. Acad. Sci. USA, 105, 8280-8285.

Yuan, Jian-Min, Chyan, Chia-Lin, Zhou, Huan-Xiang, Chung, Tse-Yu, Peng, H., Ping, G., &

Yang, G. (2008). The effects of macromolecular crowding on the mechanical stability of

protein molecules. PROTEIN SCIENCE, 17(12), 2156-2166. doi:10.1110/ps.037325.108

Zhou, Huan-Xiang. (2008). A minimum-reaction-flux solution to master-equation models of

protein folding. JOURNAL OF CHEMICAL PHYSICS, 128(19), 195104.

doi:10.1063/1.2929824

Zhou, Huan-Xiang. (2008). Calculation of free-energy differences and potentials of mean force

by a multi-energy gap method. JOURNAL OF CHEMICAL PHYSICS, 128(11), 11404.

doi:10.1063/1.2841942

Zhou, Huan-Xiang. (2008). Effect of mixed macromolecular crowding agents on protein folding.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 72(4), 1109-1113.

doi:10.1002/prot.22111

Zhou, Huan-Xiang. (2008). The debut of PMC Biophysics. PMC Biophysics, 1, 1.

Vita for Huan-Xiang Zhou

Page 16

Zhou, Huan-Xiang, Qin, S., & Tjong, H. (2008). Modeling protein-protein and protein-nucleic

acid interactions: structure, thermodynamics, and kinetics. Annu. Report Comput. Chem,

4, 67-87. doi:10.1016/S1574-1400(08)00004-2

Zhou, Huan-Xiang, Rivas, G., & Minton, A. P. (2008). Macromolecular crowding and

confinement: Biochemical, biophysical, and potential physiological consequences.

ANNUAL REVIEW OF BIOPHYSICS, 37, 375-397.

doi:10.1146/annurev.biophys.37.032807.125817

Zhou, Huari-Xiang. (2008). Protein folding in confined and crowded environments. ARCHIVES

OF BIOCHEMISTRY AND BIOPHYSICS, 469(1), 76-82. doi:10.1016/j.abb.2007.07.013

Alsallaq, R., & Zhou, Huan-Xiang. (2007). Energy landscape and transition state of

protein-protein association. BIOPHYSICAL JOURNAL, 92(5), 1486-1502.

doi:10.1529/biophysj.106.096024

Alsallaq, R., & Zhou, Huan-Xiang. (2007). Prediction of protein-protein association rates from a

transition-state theory. STRUCTURE, 15(2), 215-224. doi:10.1016/j.str.2007.01.005

Bhattacharya, N., Yi, M., Zhou, Huan-Xiang, & Logan, T. M. (2007). Backbone dynamics in an

intramolecular prolyipeptide-SH3 complex from the diphtheria toxin repressor, DtxR.

JOURNAL OF MOLECULAR BIOLOGY, 374(4), 977-992.

doi:10.1016/j.jmb.2007.09.063

Gilson, M. K., & Zhou, Huan-Xiang. (2007). Calculation of protein-ligand binding affinities.

ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 36, 21-42.

doi:10.1146/annurev.biophys.36.040306.132550

Qin, S., & Zhou, Huan-Xiang. (2007). A holistic approach to protein docking.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 69(4), 743-749.

doi:10.1002/prot.21752

Qin, S., & Zhou, Huan-Xiang. (2007). Do electrostatic interactions destabilize protein-nucleic

acid binding? BIOPOLYMERS, 86(2), 112-118. doi:10.1002/bip.20708

Qin, S., & Zhou, Huan-Xiang. (2007). meta-PPISP: a meta web server for protein-protein

interaction site prediction. BIOINFORMATICS, 23(24), 3386-3387.

doi:10.1093/bioinformatics/btm434

Tjong, H., Qin, S., & Zhou, Huan-Xiang. (2007). PI2PE: protein interface/interior prediction

engine. NUCLEIC ACIDS RESEARCH, 35(S), W357-W362. doi:10.1093/nar/gkm231

Tjong, H., & Zhou, Huan-Xiang. (2007). DISPLAR: an accurate method for predicting

DNA-binding sites on protein surfaces. NUCLEIC ACIDS RESEARCH, 35(5),

1465-1477. doi:10.1093/nar/gkm008

Vita for Huan-Xiang Zhou

Page 17

Tjong, H., & Zhou, Huan-Xiang. (2007). GBr6: A parameterization-free, accurate, analytical

generalized born method. JOURNAL OF PHYSICAL CHEMISTRY B, 111(11),

3055-3061. doi:10.1021/jp066284c

Tjong, H., & Zhou, Huan-Xiang. (2007). GBr6NL: A generalized Born method for accurately

reproducing solvation energy of the nonlinear Poisson-Boltzmann equation. JOURNAL

OF CHEMICAL PHYSICS, 126(19), 195102. doi:10.1063/1.2735322

Zhou, Huan-Xiang. (2007). Helix formation inside a nanotube: Possible influence of

backbone-water hydrogen bonding by the confining surface through modulation of water

activity. JOURNAL OF CHEMICAL PHYSICS, 127(24), 245101. doi:10.1063/1.2812282

Zhou, Huan-Xiang, & Qin, S. (2007). Interaction-site prediction for protein complexes: a critical

assessment. BIOINFORMATICS, 23(17), 2203-2209. doi:10.1093/bioinformatics/btm323

Dong, F., & Zhou, Huan-Xiang. (2006). Electrostatic contribution to the binding stability of

protein-protein complexes. PROTEINS-STRUCTURE FUNCTION AND

BIOINFORMATICS, 65(1), 87-102. doi:10.1002/prot.21070

Hu, J., Fu, R., Nishimura, K., Zhang, L., Zhou, Huan-Xiang, Busath, D., Vijayvergiya, V., &

Cross, T. (2006). Histidines, heart of the hydrogen ion channel from influenza A virus:

Toward an understanding of conductance and proton selectivity. PROCEEDINGS OF

THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,

103(18), 6865-6870. doi:10.1073/pnas.0601944103

Huang, X., & Zhou, Huan-Xiang. (2006). Similarity and difference in the unfolding of

thermophilic and mesophilic cold shock proteins studied by molecular dynamics.

BIOPHYSICAL JOURNAL, 91(7), 2451-2463. doi:10.1529/biophysj.106.082891

Tjong, H., & Zhou, Huang-Xiang. (2006). The dependence of electrostatic solvation energy on

dielectric constants in Poisson-Boltzmann calculations. JOURNAL OF CHEMICAL

PHYSICS, 125(20), 206101. doi:10.1063/1.2393243

Zhou, Huan-Xiang. (2006). Quantitative relation between intermolecular and intramolecular

binding of pro-rich peptides to SH3 domains. BIOPHYSICAL JOURNAL, 91(9),

3170-3181. doi:10.1529/biophysj.106.090258

Berg, B. A., & Zhou, H.-X. (2005). Rugged Metropolis sampling with simultaneous updating of

two dynamical variables. PHYSICAL REVIEW E, 72(1, 2), 016712.

doi:10.1103/PhysRevE.72.016712

Chen, H. L., & Zhou, H.-X. (2005). Prediction of solvent accessibility and sites of deleterious

mutations from protein sequence. NUCLEIC ACIDS RESEARCH, 33(10), 3193-3199.

doi:10.1093/nar/gki633

Vita for Huan-Xiang Zhou

Page 18

Chen, H., & Zhou, Huan-Xiang. (2005). Prediction of interface residues in protein-protein

complexes by a consensus neural network method: Test against NMR data.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 61(1), 21-35.

doi:10.1002/prot.20514

Huang, X. Q., Dong, F., & Zhou, H.-X. (2005). Electrostatic recognition and induced fit in the

k-PVIIA toxin binding to Shaker potassium channel. JOURNAL OF THE AMERICAN

CHEMICAL SOCIETY, 127(18), 6836-6849. doi:10.1021/ja042641q

Spencer, D. S., Xu, K., Logan, T. M., & Zhou, H.-X. (2005). Effects of pH, salt, and

macromolecular crowding on the stability of FK506-binding protein: An integrated

experimental and theoretical study. JOURNAL OF MOLECULAR BIOLOGY, 351(1),

219-232. doi:10.1016/j.jmb.2005.05.029

van Dijk, A. D. J., de Vries, S. J., Dominguez, C., Chen, H., Zhou, H.-X., & Bonvin, A. M. J. J.

(2005). Data-driven docking: HADDOCK's adventures in CAPRI.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 60(2), 232-238.

doi:10.1002/prot.20563

Zhou, H.-X. (2005). A model for the mediation of processivity of DNA-targeting proteins by

nonspecific binding: Dependence on DNA length and presence of obstacles.

BIOPHYSICAL JOURNAL, 88(3), 1608-1615. doi:10.1529/biophysj.104.052688

Zhou, Huan-Xiang. (2005). How do biomolecular systems speed up and regulate rates?

PHYSICAL BIOLOGY, 2(3), R1-R25. doi:10.1088/1478-3975/2/3/R01

Zhou, Huan-Xiang. (2005). Interactions of macromolecules with salt ions: An electrostatic

theory for the Hofmeister effect. PROTEINS-STRUCTURE FUNCTION AND

BIOINFORMATICS, 61(1), 69-78. doi:10.1002/prot.20500

Zhou, H.-X. (2004). Improving the understanding of human genetic diseases through predictions

of protein structures and protein-protein interaction sites. CURRENT MEDICINAL

CHEMISTRY, 11(5), 539-549. doi:10.2174/0929867043455800

Zhou, H.-X. (2004). Loops, linkages, rings, catenanes, cages, and crowders: Entropy-based

strategies for stabilizing proteins. ACCOUNTS OF CHEMICAL RESEARCH, 37(2),

123-130. doi:10.1021/ar0302282

Zhou, H.-X. (2004). Polymer models of protein stability, folding, and interactions.

BIOCHEMISTRY, 43(8), 2141-2154. doi:10.1021/bi036269n

Zhou, H.-X. (2004). Protein folding and binding in confined spaces and in crowded solutions.

JOURNAL OF MOLECULAR RECOGNITION, 17(5), 368-375. doi:10.1002/jmr.711

Vita for Huan-Xiang Zhou

Page 19

Zhou, H.-X., & Szabo, A. (2004). Enhancement of association rates by nonspecific binding to

DNA and cell membranes. PHYSICAL REVIEW LETTERS, 93(17), 178101.

doi:10.1103/PhysRevLett.93.178101

Dong, F., Vijayakumar, M., & Zhou, H.-X. (2003). Comparison of calculation and experiment

implicates significant electrostatic contributions to the binding stability of barnase and

barstar. BIOPHYSICAL JOURNAL, 85(1), 49-60.

Zhou, H.-X. (2003). Association and dissociation kinetics of colicin E3 and immunity protein 3:

Convergence of theory and experiment. PROTEIN SCIENCE, 12(10), 2379-2382.

doi:10.1110/ps.03216203

Zhou, H.-X. (2003). Direct test of the Gaussian-chain model for treating residual charge-charge

interactions in the unfolded state of proteins. JOURNAL OF THE AMERICAN

CHEMICAL SOCIETY, 125(8), 2060-2061. doi:10.1021/ja0298491

Zhou, H.-X. (2003). Effect of backbone cyclization on protein folding stability: Chain entropies

of both the unfolded and the folded states are restricted. JOURNAL OF MOLECULAR

BIOLOGY, 332(1), 257-264. doi:10.1016/S0022-2836(03)00886-6

Zhou, H.-X. (2003). Effect of catenation on protein folding stability. JOURNAL OF THE

AMERICAN CHEMICAL SOCIETY, 125(31), 9280-9281. doi:10.1021/ja0355978

Zhou, H.-X. (2003). How often does the myristoylated N-terminal latch of c-Abl come off?

FEBS Lett, 552, 160-162.

Zhou, H.-X. (2003). Quantitative account of the enhanced affinity of two linked scFvs specific

for different epitopes on the same antigen. JOURNAL OF MOLECULAR BIOLOGY,

329(1), 1-8. doi:10.1016/S0022-2836(03)00372-3

Zhou, H.-X. (2003). Theory for the rate of contact formation in a polymer chain with local

conformational transitions. JOURNAL OF CHEMICAL PHYSICS, 118(4), 2010-2015.

doi:10.1063/1.1531588

Zhou, H.-X., & Dong, F. (2003). Electrostatic contributions to the stability of a thermophilic cold

shock protein. BIOPHYSICAL JOURNAL, 84(4), 2216-2222.

doi:10.1016/S0006-3495(03)75027-9

Boschitsch, A. H., Fenley, M. O., & Zhou, H.-X. (2002). Fast boundary element method for the

linear Poisson-Boltzmann equation. JOURNAL OF PHYSICAL CHEMISTRY B, 106(10),

2741-2754. doi:10.1021/jp013607q

Dong, F., & Zhou, H.-X. (2002). Electrostatic contributions to T4 lysozyme stability:

Solvent-exposed charges versus semi-buried salt bridges. BIOPHYSICAL JOURNAL,

83(3), 1341-1347.

Vita for Huan-Xiang Zhou

Page 20

Zhou, H.-X. (2002). A Gaussian-chain model for treating residual charge-charge interactions in

the unfolded state of proteins. PROCEEDINGS OF THE NATIONAL ACADEMY OF

SCIENCES OF THE UNITED STATES OF AMERICA, 99(6), 3569-3574.

doi:10.1073/pnas.052030599

Zhou, H.-X. (2002). Dimensions of denatured protein chains from hydrodynamic data.

JOURNAL OF PHYSICAL CHEMISTRY B, 106(22), 5769-5775. doi:10.1021/jp013403+

Zhou, H.-X. (2002). Model for the binding of the inactivation N-terminal to the ion pore of

shaker potassium channel: Both electrostatic attraction and covalent linkage are required

for rapid inactivation. JOURNAL OF PHYSICAL CHEMISTRY B, 106(9), 2393-2397.

doi:10.1021/jp013859r

Zhou, H.-X. (2002). Residual charge interactions in unfolded staphylococcal nuclease can be

explained by the Gaussian-chain model. BIOPHYSICAL JOURNAL, 83(6), 2981-2986.

Zhou, H.-X. (2002). Residual electrostatic effects in the unfolded state of the N-terminal domain

of L9 can be attributed to nonspecific nonlocal charge-charge interactions.

BIOCHEMISTRY, 41(20), 6533-6538. doi:10.1021/bi025580m

Zhou, H.-X. (2002). Toward the physical basis of thermophilic proteins: Linking of enriched

polar interactions and reduced heat capacity of unfolding. BIOPHYSICAL JOURNAL,

83(6), 3126-3133.

Zhou, H.-X., & Zwanzig, R. (2002). Barrier crossing coupled to a small set of oscillators.

JOURNAL OF PHYSICAL CHEMISTRY A, 106(33), 7562-7564. doi:10.1021/jp013707w

Shan, Y. B., Wang, G. L., & Zhou, H.-X. (2001). Fold recognition and accurate query-template

alignment by a combination of PSI-BLAST and threading. PROTEINS-STRUCTURE

FUNCTION AND GENETICS, 42(1), 23-37.

doi:10.1002/1097-0134(20010101)42:1[23::AID-

Vijayakumar, M., & Zhou, H.-X. (2001). Salt bridges stabilize the folded structure of barnase.

JOURNAL OF PHYSICAL CHEMISTRY B, 105(30), 7334-7340. doi:10.1021/jp011214l

Zhou, H.-X. (2001). A unified picture of protein hydration: prediction of hydrodynamic

properties from known structures. BIOPHYSICAL CHEMISTRY, 93(2-3, SI), 171-179.

doi:10.1016/S0301-4622(01)00219-8

Zhou, H.-X. (2001). Disparate ionic-strength dependencies of on and off rates in protein-protein

association. BIOPOLYMERS, 59(6), 427-433.

doi:10.1002/1097-0282(200111)59:6[427::AID-B

Zhou, H.-X. (2001). Loops in proteins can be modeled as worm-like chains. JOURNAL OF

PHYSICAL CHEMISTRY B, 105(29), 6763-6766. doi:10.1021/jp011355n

Vita for Huan-Xiang Zhou

Page 21

Zhou, H.-X. (2001). Single-chain versus dimeric protein folding: Thermodynamic and kinetic

consequences of covalent linkage. JOURNAL OF THE AMERICAN CHEMICAL

SOCIETY, 123(27), 6730-6731. doi:10.1021/ja015990i

Zhou, H.-X. (2001). The affinity-enhancing roles of flexible linkers in two-domain

DNA-Binding proteins. BIOCHEMISTRY, 40(50), 15069-15073. doi:10.1021/bi015795g

Zhou, H.-X., & Dill, K. A. (2001). Stabilization of proteins in confined spaces.

BIOCHEMISTRY, 40(38), 11289-11293. doi:10.1021/bi0155504

Zhou, H.-X., & Shan, Y. B. (2001). Prediction of protein interaction sites from sequence profile

and residue neighbor list. PROTEINS-STRUCTURE FUNCTION AND GENETICS,

44(3), 336-343. doi:10.1002/prot.1099

Zhou, H.-X., & Wang, G. (2001). Predicted structures of two proteins involved in human

diseases. CELL BIOCHEMISTRY AND BIOPHYSICS, 35(1), 35-47.

doi:10.1385/CBB:35:1:35

Shan, Y. B., & Zhou, H.-X. (2000). Correspondence of potentials of mean force in proteins and

in liquids. JOURNAL OF CHEMICAL PHYSICS, 113(11), 4794-4798.

doi:10.1063/1.1288920

Vijayakumar, M., & Zhou, H.-X. (2000). Prediction of residue-residue pair frequencies in

proteins. JOURNAL OF PHYSICAL CHEMISTRY B, 104(41), 9755-9764.

doi:10.1021/jp001757f

Berezhkovskii, A. M., Szabo, A., Weiss, G., & Zhou, H.-X. (1999). Reaction dynamics on a

thermally fluctuating potential. JOURNAL OF CHEMICAL PHYSICS, 111(22),

9952-9957. doi:10.1063/1.480348

Vijayakumar, M., Qian, H., & Zhou, H.-X. (1999). Hydrogen bonds between short polar side

chains and peptide backbone: Prevalence in proteins and effects on helix-forming

propensities. PROTEINS-STRUCTURE FUNCTION AND GENETICS, 34(4), 497-507.

doi:10.1002/(SICI)1097-0134(19990301)34:4[49

Vijayakumar, M., Wong, K.-Y., Schreiber, G., Fersht, A. R., Szabo, A., & Zhou, H.-X. (1998).

Electrostatic enhancement of diffusion-controlled protein-protein association:

Comparison of theory and experiment on barnase and barstar. JOURNAL OF

MOLECULAR BIOLOGY, 278(5), 1015-1024. doi:10.1006/jmbi.1998.1747

Zhou, H.-X. (1998). Comparison of three Brownian-dynamics algorithms for calculating rate

constants of diffusion-influenced reactions. JOURNAL OF CHEMICAL PHYSICS,

108(19), 8139-8145. doi:10.1063/1.476254

Vita for Huan-Xiang Zhou

Page 22

Zhou, H.-X. (1998). Theory of the diffusion-influenced substrate binding rate to a buried and

gated active site. JOURNAL OF CHEMICAL PHYSICS, 108(19), 8146-8154.

doi:10.1063/1.476255

Zhou, H.-X., Briggs, J. M., Tara, S., & McCammon, J. A. (1998). Correlation between rate of

enzyme-substrate diffusional encounter and average boltzmann factor around active site.

BIOPOLYMERS, 45(5), 355-360. doi:10.1002/(SICI)1097-0282(19980415)45:5[35

Zhou, H.-X., Wlodek, S. T., & McCammon, J. A. (1998). Conformation gating as a mechanism

for enzyme specificity. PROCEEDINGS OF THE NATIONAL ACADEMY OF

SCIENCES OF THE UNITED STATES OF AMERICA, 95(16), 9280-9283.

doi:10.1073/pnas.95.16.9280

Zhou, H.-X. (1997). Control of reduction potential by protein matrix: Lesson from a spherical

protein model. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2(1), 109-113.

doi:10.1007/s007750050113

Zhou, H.-X. (1997). Enhancement of protein-protein association rate by interaction potential:

Accuracy of prediction based on local Boltzmann factor. BIOPHYSICAL JOURNAL,

73(5), 2441-2445.

Zhou, H.-X. (1997). Theory and simulation of the influence of diffusion in enzyme-catalyzed

reactions. JOURNAL OF PHYSICAL CHEMISTRY B, 101(33), 6642-6651.

doi:10.1021/jp971208i

Zhou, H.-X., & Vijayakumar, M. (1997). Modeling of protein conformational fluctuations in

pK(a) predictions. JOURNAL OF MOLECULAR BIOLOGY, 267(4), 1002-1011.

doi:10.1006/jmbi.1997.0895

Zhou, H.-X., Wong, K.-Y., & Vijayakumar, M. (1997). Design of fast enzymes by optimizing

interaction potential in active site. PROCEEDINGS OF THE NATIONAL ACADEMY OF

SCIENCES OF THE UNITED STATES OF AMERICA, 94(23), 12372-12377.

doi:10.1073/pnas.94.23.12372

Potter, M. J., Luty, B., Zhou, H.-X., & McCammon, J. A. (1996). Time-dependent rate

coefficients from Brownian dynamics simulations. JOURNAL OF PHYSICAL

CHEMISTRY, 100(12), 5149-5154. doi:10.1021/jp953229n

Zhou, H.-X. (1996). Dielectric continuum model for calculating reorganization free energies of

electron transfer in proteins. JOURNAL OF CHEMICAL PHYSICS, 105(9), 3726-3733.

doi:10.1063/1.472192

Zhou, H.-X. (1996). Effect of interaction potentials in diffusion-influenced reactions with small

reactive regions. JOURNAL OF CHEMICAL PHYSICS, 105(16), 7235-7237.

doi:10.1063/1.472530

Vita for Huan-Xiang Zhou

Page 23

Zhou, H.-X., Briggs, J. M., & McCammon, J. A. (1996). A 240-fold electrostatic

rate-enhancement for acetylcholinesterase-substrate binding can be predicted by the

potential within the active site. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,

118(51), 13069-13070. doi:10.1021/ja963134e

Zhou, H.-X., & Chen, Y. D. (1996). Chemically driven motility of Brownian particles.

PHYSICAL REVIEW LETTERS, 77(1), 194-197. doi:10.1103/PhysRevLett.77.194

Zhou, H.-X., & Szabo, A. (1996). Theory and simulation of stochastically-gated

diffusion-influenced reactions. JOURNAL OF PHYSICAL CHEMISTRY, 100(7),

2597-2604. doi:10.1021/jp952376i

Zhou, H.-X., & Szabo, A. (1996). Theory and simulation of the time-dependent rate coefficients

of diffusion-influenced reactions. BIOPHYSICAL JOURNAL, 71(5), 2440-2457.

Ernst, J. A., Clubb, R. T., Zhou, H.-X., Groenenborn, A. M., & Clore, C. M. (1995). Use of

NMR to detect water within nonpolar protein cavities. Science, 270, 1848-1849.

Ernst, J. A., Clubb, R. T., Zhou, H.-X., Gronenborn, A. M., & Clore, G. M. (1995).

Demonstration of positionally disordered water within a protein hydrophobic cavity by

NMR. SCIENCE, 267, 1813-1817.

Zhou, H.-X. (1995). Calculation of translational friction and intrinsic viscosity. I. General

formulation for arbitrarily shaped particles. BIOPHYSICAL JOURNAL, 69(6),

2286-2297. doi:10.1016/S0006-3495(95)80099-8

Zhou, H.-X. (1995). Calculation of translational friction and intrinsic viscosity. II. Application to

globular proteins. BIOPHYSICAL JOURNAL, 69(6), 2298-2303.

doi:10.1016/S0006-3495(95)80100-1

Zhou, H.-X., & Szabo, A. (1995). Microscopic formulation of Marcus' theory of electron

transfer. Journal of Chemical Physics, 103, 3481-3494.

Douglas, J. F., Zhou, H.-X., & Hubbard, J. B. (1994). Hydrodynamic friction and the

electrostatic capacitance of an arbitrarily-shaped objects. Physical Review E, 49,

5319-5331.

Zhou, H.-X. (1994). Effects of mutations and complex formation on the redox potentials of

cytochrome c and cytochrome c peroxidase. Journal of the American Chemical Society,

116, 10362-10375.

Zhou, H.-X. (1994). Macromolecular electrostatic energy within the nonlinear

Poisson-Boltzmann equation. Journal of Chemical Physics, 100, 3152-3162.

Vita for Huan-Xiang Zhou

Page 24

Zhou, H.-X., Szabo, A., Douglas, J. F., & Hubbard, J. B. (1994). A Brownian dynamics

algorithm for calculating the hydrodynamic friction and the electrostatic capacitance of

an arbitrarily-shaped object. Journal of Chemical Physics, 100, 3821-3826.

Schaad, O., Zhou, H.-X., Henry, E. R., Szabo, A., & Eaton, W. A. (1993). Simulation of the

kinetics of ligand binding to a protein by molecular dynamics: geminate rebinding of

nitric oxide to myoglobin. BIOPHYSICAL JOURNAL, 64(2, 2), A43.

Zhou, H. (1993). Dynamic spherical model for solvation in a dipolar lattice. Journal of Physical

Chemistry, 97, 4216-4223.

Zhou, H.-X. (1993). Boundary element solution of macromolecular electrostatics: interaction

energy between two proteins. Biophysical Journal, 65, 955-963.

Zhou, H.-X. (1993). Brownian dynamics study of the influences of electrostatic interaction and

diffusion on protein-protein association kinetics. BIOPHYSICAL JOURNAL, 64(2, 2),

1711-1726.

Luty, B. A., McCammon, J. A., & Zhou, H.-X. (1992). Diffusive reaction rates from Brownian

dynamics simulations: replacing the outer cut-off surface by an analytical treatment.

Journal of Chemical Physics, 97, 5682-5686.

Zhou, H.-X., & Bagchi, B. (1992). Dielectric and orientational relaxation in a Brownian dipolar

lattice. JOURNAL OF CHEMICAL PHYSICS, 97(5), 3610-3620. doi:10.1063/1.462944

Zhou, H.-X., Bagchi, B., Papazyan, A., & Maroncelli, M. (1992). Solvation dynamics in a

Brownian dipole lattice: a comparison between theory and computer simulation.

JOURNAL OF CHEMICAL PHYSICS, 97(12), 9311-9390. doi:10.1063/1.463307

Zhou, H. X., & Szabo, A. (1991). Comparison between molecular dynamics simulations and the

Smoluchowski theory of reactions in a hard sphere liquid. Journal of Chemical Physics,

95, 5948-5952.

Zhou, H. X., & Zwanzig, R. (1991). A rate process with an entropy barrier. JOURNAL OF

CHEMICAL PHYSICS, 94(9), 6147-6152. doi:10.1063/1.460427

Zhou, H. X., & Ferrone, F. A. (1990). Theoretical description of the spatial dependence of sickle

hemoglobin polymerization. BIOPHYSICAL JOURNAL, 58(3), 695-703.

Zhou, H.-X. (1990). Kinetics of diffusion-influenced reactions studied by Brownian dynamics.

Journal of Physical Chemistry, 94, 8794-8800.

Zhou, H.-X. (1990). On the calculation of diffusive reaction rates using Brownian dynamics

simulations. Journal of Chemical Physics, 92, 3092-3095.

Vita for Huan-Xiang Zhou

Page 25

Zhou, H.-X., & Szabo, A. (1990). Mean field theory of transient fluorescence quenching in the

frequency domain. Journal of Chemical Physics, 92, 3874-3880.

Zhou, H. X. (1989). The exponential nature of barrier crossings studied by Langevin dynamics.

Chemical Physics Letters, 164, 285-290.

Ferrone, F. A., Basak, S., Martino, A. J., Zhou, H. X., Qin, S., Tjong, H., & Zhou, H. (1987).

Polymer domains, gelation models and sickle cell crises. Prog Clin Biol Res, 240, 47-58.

Edited Books

Yuan, J. M., & Zhou, H. X. (Eds.). (in press). Biophysics and Biochemistry of Protein

Aggregation [Edited Book]. Singapore: World Scientific.

Refereed Book Chapters

Tjong, H., & Zhou, H. X. (2010). Modeling protein solubility in implicit solvent. In Michael

Feig (Ed.), Modeling Solvent Environments (pp. 191-207). Weinheim: Wiley-VCH.

Zhou, H.-X. (1995). Continuum-model studies of redox reactions, complex formation, and

electron transfer: the paradigm of cytochrome c and cytochrome c peroxidase. In J.

Jortner, & B. Pullman (Eds.), Modelling of Biomolecular Structures and Mechanisms (pp.

381-398). Dordrecht: Kluwer Academic Publishers.

Invited Encyclopedia Entries

Zhou, H. X. (2017). Biophysics: past, present, and future. In Huan-Xiang Zhou (Ed.), Reference

Module in Life Sciences. Elsevier. Retrieved from

http://dx.doi.org/10.1016/B978-0-12-809633-8.12385-4

Refereed Proceedings

Kazi, R., Dai, J., Jin, T., Zhou, Huan-Xiang, & Wollmuth, L. P. (2013). Biophysical Coupling

Mechanisms in NMDA Receptor Gating. In 57th Annual Meeting of the

Biophysical-Society, Philadelphia, PA (pp. 273A-274A). BIOPHYSICAL JOURNAL.

Yi, M., Dong, H., & Zhou, Huan-Xiang. (2013). Molecular Basis for the Ion Selectivity of Gap

Junction Channels Elucidated by Molecular Dynamics Simulations. In 57th Annual

Meeting of the Biophysical-Society, Philadelphia, PA (pp. 409A-410A). BIOPHYSICAL

JOURNAL.

Vita for Huan-Xiang Zhou

Page 26

Das, N., Dai, J., Hung, I., Tian, Y., Marassi, F. M., Opella, S. J., Zhou, H. X., Rajagopalan, M.,

& Cross, T. A. (2013). Structure-Function Studies of Mtb Membrane Protein CrgA in

Lipid Bilayer. In 57th Annual Meeting of the Biophysical-Society, Philadelphia, PA (pp.

219A-220A). BIOPHYSICAL JOURNAL.

Cross, T. A., Sharma, M., Yi, M., Dong, H., Qin, H., Peterson, E., Busath, D. D., & Zhou, H-X.

(2011). The native M2 proton channel structure from influenza A. In 8th EBSA European

Biophysics Congress, Budapest, HUNGARY (pp. 194). EUROPEAN BIOPHYSICS

JOURNAL WITH BIOPHYSICS LETTERS, 40(1).

Zhou, Huan-Xiang. (2011). Automated prediction of protein-protein binding rate constants. In

242nd National Meeting of the American-Chemical-Society (ACS), Denver, CO.

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.

Tjong, H., & Zhou, Huan-Xiang. (2008). Accurate calculations of binding and folding free

energies by a scaled generalized Born method. In 236th National Meeting of the

American-Chemical-Society, Philadelphia, PA. ABSTRACTS OF PAPERS OF THE

AMERICAN CHEMICAL SOCIETY, 236.

Zhou, Huan-Xiang, & Batra, J. (2008). Theoretical and experimental studies of macromolecular

crowding on protein folding. In 236th National Meeting of the

American-Chemical-Society, Philadelphia, PA. ABSTRACTS OF PAPERS OF THE

AMERICAN CHEMICAL SOCIETY, 236.

Presentations

Invited Papers at Conferences

Qin, S., & Zhou, H. X. (presented 2016, December). Liquid-Liquid Phase Separation of Proteins

and Regulation of Cellular Functions. Paper presented at Workshop on "Mathematics

Biophysics and Molecular Biosciences", Tsinghua Sanya International Mathematics

Forum. (International)

Qin, S., & Zhou, H. X. (presented 2016, October). Modeling Intermolecular Interactions and

Liquid-Liquid Phase Equilibria in Cell-Like Conditions. Paper presented at Conference

on "Modeling of Protein Interactions", University of Kansas, University of Kansas.

(International)

Qin, S., & Zhou, H. X. (presented 2016, August). Modeling Intermolecular Interactions and

Liquid-Liquid Phase Equilibria in Cell-Like Conditions. Paper presented at American

Chemical Society Fall National Meeting, American Chemical Society, Philadelphia.

(International)

Smith, P., Banks, A., & Zhou, H. X. (presented 2016, August). Conformations and Exchange

Dynamics of FlgM, an Intrinsically Disordered Protein, in Dilute and Crowded

Vita for Huan-Xiang Zhou

Page 27

Conditions. Paper presented at American Chemical Society Fall National Meeting,

American Chemical Society, Philadelphia. (International)

Zhou, H. X. (presented 2016, July). Protein Allostery and Conformational Dynamics. Paper

presented at Workshop on "Frontiers in Molecular Biophysics", New York University

Shanghai, Shanghai. (International)

Zhou, H. X. (presented 2016, June). Atomistic Modeling of Liquid-Liquid Phase Separation of

Protein Solutions. Paper presented at Telluride Workshop on "Protein and Peptide

Interactions in Cellular Environments", Telluride Science Research Center, Telluride,

CO. (International)

Zhou, H. X. (presented 2016, May). Protein Allostery and Conformational Dynamics. Paper

presented at Focused Program on "Molecular Machines of Life: Simulation Meets

Experiment", Hong Kong University of Science and Technology, Hong Kong.

(International)

Zhou, H. X. (presented 2016, April). Model Selection for Protein-Peptide and Protein-Protein

Complexes Using Consensus Residue Positions and Predicted Interface Residues. Paper

presented at Sixth CAPRI Evaluation Meeting, CAPRI Meeting Organizing Committee,

Tel Aviv. (International)

Zhou, H. X. (presented 2016, March). Protein Allostery and Conformational Dynamics. Paper

presented at American Chemical Society Spring National Meeting, American Chemical

Society, San Diego. (International)

Invited Lectures and Readings of Original Work

Zhou, H. X. (2017, January). Integrated Computational and Experimental Studies on the

Structure and Function of Ion Channels. Delivered at Department of Biochemistry and

Structural Biology, University of Texas Health Science Center at San Antonio. (Local)

Zhou, H. X. (2017, January). Integrated Computational and Experimental Studies on the

Structure and Function of Ion Channels. Delivered at Department of Chemistry,

University of Colorado Denver. (Local)

Zhou, H. X. (2016, November). Electrostatics in Protein Structure and Action. Delivered at

Michigan State University. (Local)

Zhou, H. X. (2016, October). Electrostatics in Protein Structure and Action. Delivered at

University of Houston. (Local)

Zhou, H. X. (2016, July). Electrostatics in protein Structure and Action. Delivered at New York

University Shanghai. (Local)

Vita for Huan-Xiang Zhou

Page 28

Zhou, H. X. (2016, July). Integrated Computational and Experimental Studies on the Structure

and Function of Ion Channels. Delivered at Fudan University, China. (Local)

Zhou, H. X. (2016, July). Integrated Computational and Experimental Studies on the Structure

and Function of Ion Channels. Delivered at Nanjing University, China. (Local)

Zhou, H. X. (2016, July). Protein Phase Transition and Regulation of Cellular Functions.

Delivered at Nanjing University, China. (Local)

Zhou, H. X. (2016, July). Toward Achieving Clarity in Scientific Communication. Delivered at

Nanjing University, China. (Local)

Zhou, H. X. (2016, May). Electrostatics in Protein Structure and Action. Delivered at Chinese

University of Hong Kong. (Local)

Zhou, H. X. (2016, April). Protein Allostery and Conformational Dynamics. Delivered at Indiana

University School of Medicine. (Local)

Zhou, H. X. (2016, March). Protein Allostery and Conformational Dynamics. Delivered at

University of South Florida. (Local)

Patented Inventions

Sharma, M., Yi, M., Dong, H., Qin, H., Busath, D. D., Zhou, H. -X., & Cross, T. A. (2013).

Membrane Proteins, Mechanisms of Action and Uses Thereof. US Patent 8,581,584.

Contracts and Grants

Contracts and Grants Funded

Zhou, Huan-Xiang (PI). (Sep 2016–Sep 2019). Computational and Experimental Studies on the

Complexity of Protein Complex Formation in the Cell Relative to the Test Tube. Funded

by United States-Israel Binational Science. (2015376). Total award $90,000.

Zhou, Huan-Xiang (PI). (May 2016–Apr 2017). Solid State NMR Structural Analysis Of

Oligomeric Alzheimer's Beta-Amyloid. Funded by Georgia Institute of Technology.

(RG680-G1). Total award $57,786.

Zhou, Huan-Xiang (PI), Li, Hong (Co-PI), Blaber, Michael (Co-PI), Zhu, Fanxiu (Co-PI), Stagg,

Scott (Co-PI), Stroupe, Margaret (Co-PI), Li, Yan (Co-PI), Pinto, Jose Renato Dias

Oliveira (Co-PI), Bleiholder, Christian (Co-PI), & Yin, Qian (Co-PI). (May 2016–May

2017). EIEG: Acquisition of a Microscale Thermophoresis Instrument for Binding

Affinity Measurements. Funded by FSU EIEG Award. Total award $60,000.

Vita for Huan-Xiang Zhou

Page 29

Zhou, Huan-Xiang (PI). (Apr 2016–Mar 2017). Quantitative, Mechanistic Studies of

Biomolecular Recognition. Funded by National Institute of General Medical Sciences.

(R35GM118091). Total award $199,229.

Zhou, Huan-Xiang (PI). (Jan 2016–Dec 2016). Theory of Protein-Protein Association. Funded

by National Institute of General Medical Sciences. (R01GM058187). Total award

$271,688.

Cross, Timothy A (PI), & Zhou, Huan-Xiang (Co-PI). (Apr 2015–Mar 2017). Membrane Protein

Structures and Interactions in the M. Tuberculosis Divisome. Funded by National

Institute of Allergy. (1R01AI119178). Total award $1,496,222.

Zhou, Huan-Xiang (PI). (Sep 2014–Jul 2017). Modeling Crowding and Confinement of Celluair

Environments. Funded by National Institute of General Medical Sciences.

(R01GM088187). Total award $997,995.

Zhou, Huan-Xiang (Co-PI), & Paravastu, Anant K (PI). (May 2014–Nov 2015). Solid State NMR

Structural Analysis of Oligomeric Alzheimer's Beta-Amyloid Peptide. Funded by National

Institute on Aging. (R01AG045703). Total award $671,309.

Zhou, Huan-Xiang (PI). (Jan 2013–Dec 2015). Theory of Protein-Protein Association. Funded

by National Institute of General Medical Sciences. (R01GM058187). Total award

$1,020,824.

Zhou, Huan-Xiang (Co-PI), & Miklos, Andrew C (PI). (Aug 2012–Aug 2014). Protien-Ligand

Binding Equilibrium and Mechanism Under Macromolecular Crowding. Funded by

National Institute of General Medical Sciences. (1F32GM103217). Total award

$101,404.

Cross, Timothy A (PI), Fu, Riqiang (Co-PI), & Zhou, Huan-Xiang (Co-PI). (Aug 2011–Jul

2015). Correlations: Structure-Dynamics-Function in Channels. Funded by National

Institute of Allergy. (R01AI023007). Total award $1,848,827.

Zhou, Huan-Xiang (PI). (Aug 2010–Jul 2014). Modeling Crowding and Confinement of Cellular

Environments. Funded by National Institute of General Medical Sciences.

(R01GM088187). Total award $994,634.

Zhou, Huan-Xiang (PI). (Sep 2009–Aug 2011). Theory of Protein-Protein Association. Funded

by National Institute of General Medical Sciences. (R01GM058187). Total award

$245,174.

Zhou, Huan-Xiang (PI). (Apr 2008–Jan 2013). Theory of Protein-Protein Association. Funded

by National Institute of General Medical Sciences. (R01GM058187). Total award

$1,100,475.

Vita for Huan-Xiang Zhou

Page 30

Zhou, Huan-Xiang (PI). (Apr 2005–Mar 2006). PG2_Folding & Binding of Fk506 Binding

Protein. Funded by FSU CRC. Total award $10,000.

Cross, Timothy A (PI), Fu, Riqiang (Co-PI), & Zhou, Huan-Xiang (Co-PI). (Mar 2005–Feb

2011). Correlations: Structure-Dynamics-Functions in Channels. Funded by National

Institute of Allergy. (R01AI023007). Total award $1,726,292.

Zhou, Huan-Xiang (PI). (Aug 2003–Mar 2008). Theory of Protein-Protein Association. Funded

by National Institute of General Medical Sciences. (RO1 GM058187). Total award

$933,833.

Postdoctoral Supervision

Che, X. (Oct 2016–present).

Smith, P. (Feb 2015–present).

Wu, D. (Dec 2014–present).

Guo, C. (Sep 2014–present).

Pang, X. (Oct 2010–present).

Qin, S. (Aug 2006–present).

Service

Florida State University

FSU Department Service

Member, Qualifying Exam Committee (2013–present).

Member, Planning Committee (2010–present).

Member, Graduate Affairs Committee (2010–2012).

The Profession

Editor for Refereed Journals

Editorial Board, Protein Engineering, Design and Selection (2014–present).

Vita for Huan-Xiang Zhou

Page 31

Editor-in-Chief; Section Editor, PMC Biophysics; BMC Biophysics (2008–present).

Associate Editor, Cell Biochemistry and Biophysics (1998–present).

Editor for Nonrefereed Journals

Biophysics Subject Editor, Elsevier's Life Science Reference Module (2016–present).

Reviewer or Panelist for Grant Applications

National Institutes of Health (2003–present).

Service to Professional Associations

Co-Chair, Biopolymers in Vivo Subgroup Symposium, Biophysical Society (2012).

Organizer, Telluride Workshop on Macromolecular Crowding (2011).

Co-Chair, IDP Subgroup Symposium, Biophysical Society (2010).

Organizer, Symposium on Protein Dynamics and Function, American Chemical Society (2009).

Organizer, Telluride Workshop on Macromolecular Crowding (2009).