2009 Surveys & Anatomic Pathology Education Programs

1 Surveys & Anatomic Pathology EducationPrograms New Developments . . . . . . . . . . . . . . . . .1–6New Developments . . . . . . . . . . . . . . . . . . . . . . . . . .1Product Fulfillment Groups . . . . . . . . . . . . . . . . . . . . .4Icon Legend . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .6

2 Customer Support and Ordering Information . . . .7–18Customer Support . . . . . . . . . . . . . . . . . . . . . . . . . . .7Ordering Instructions, Terms and Conditions . . . . . . . 8Non-Continental US and International Customers . . .11Surveys Programs Cosponsors . . . . . . . . . . . . . . . . .17

3 Continuing Education . . . . . . . . . . . . . . . . . . . .19–21Continuing Education Opportunities . . . . . . . . . . . . .19Competency Assessment Program . . . . . . . . . . . . . .22

4 Quality Management Tools . . . . . . . . . . . . . . . .25–42Q-TRACKS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .27Q-PROBES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .34LMIP . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .38CAP LINKS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .40Quality Management Tools Overview . . . . . . . . . . . .42

5 Point of Care Testing . . . . . . . . . . . . . . . . . . . . .43–46Point of Care Programs . . . . . . . . . . . . . . . . . . . . . .43

6 General Chemistry and Therapeutic DrugMonitoring . . . . . . . . . . . . . . . . . . . . . . . . . . . .47–66General Chemistry and Therapeutic DrugMonitoring . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .47General Chemistry–Related Surveys . . . . . . . . . . . . .51Urine Chemistry . . . . . . . . . . . . . . . . . . . . . . . . . . .58Special Chemistry . . . . . . . . . . . . . . . . . . . . . . . . . .60

7 Endocrinology . . . . . . . . . . . . . . . . . . . . . . . . . 67–72

8 Blood Gas, Critical Care, and Oximetry . . . . . . .73–74

9 Toxicology . . . . . . . . . . . . . . . . . . . . . . . . . . . .75–84

10 Accuracy Based Surveys . . . . . . . . . . . . . . . . . .85–88

11 Calibration Verification/Linearity andInstrumentation . . . . . . . . . . . . . . . . . . . . . . . .89–106

12 Hematology and Clinical Microscopy . . . . . . .107–120Hematology . . . . . . . . . . . . . . . . . . . . . . . . . . . . .107Clinical Microscopy . . . . . . . . . . . . . . . . . . . . . . .115

13 Reproductive Medicine . . . . . . . . . . . . . . . . .121–122

14 Coagulation . . . . . . . . . . . . . . . . . . . . . . . . .123–128

15 Microbiology . . . . . . . . . . . . . . . . . . . . . . . .129–150Bacteriology . . . . . . . . . . . . . . . . . . . . . . . . . . . . .129Mycobacteriology . . . . . . . . . . . . . . . . . . . . . . . . .137Mycology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .138Parasitology . . . . . . . . . . . . . . . . . . . . . . . . . . . . .140Virology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .143Molecular Microbiology . . . . . . . . . . . . . . . . . . . .147

16 Immunology and Flow Cytometry . . . . . . . . . .151–162Immunology . . . . . . . . . . . . . . . . . . . . . . . . . . . . .151Flow Cytometry . . . . . . . . . . . . . . . . . . . . . . . . . .159

17 Transfusion Medicine, Transfusion-TransmittedViruses, and Parentage/Relationship Testing . .163–176Transfusion Medicine . . . . . . . . . . . . . . . . . . . . . . .163Transfusion-Transmitted Viruses . . . . . . . . . . . . . . .172Parentage/Relationship Testing . . . . . . . . . . . . . . .176

18 Histocompatibility . . . . . . . . . . . . . . . . . . . . .177–182

19 Genetics and Molecular Pathology . . . . . . . . .183–192Cytogenetics . . . . . . . . . . . . . . . . . . . . . . . . . . . . .183Biochemical and Molecular Genetics . . . . . . . . . . .187Molecular Pathology . . . . . . . . . . . . . . . . . . . . . . .189

20 Anatomic Pathology . . . . . . . . . . . . . . . . . . .193–212Surgical Pathology . . . . . . . . . . . . . . . . . . . . . . . .193General Immunohistochemistry . . . . . . . . . . . . . . .197Predictive Markers . . . . . . . . . . . . . . . . . . . . . .198Cytopathology . . . . . . . . . . . . . . . . . . . . . . . . . . .200Specialty Anatomic Pathology . . . . . . . . . . . . . . . .205Cytogenetics and Molecular Pathology . . . . . . . . . .207

21 Forensic Sciences . . . . . . . . . . . . . . . . . . . . .213–216

22 Analyte Index . . . . . . . . . . . . . . . . . . . . . . . . . . .217

23 Surveys Product Shipping and Pricing . . . . . . . . . .243

24 Order Forms . . . . . . . . . . . . . . . . . . . . . . . . . . . .259

TABLE OF CONTENTS2009 Surveys & Anatomic Pathology Education Programs

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1SURVEYS &

ANATOMIC PATHOLOGYEDUCATION PROGRAMS

NEW DEVELOPMENTS

Visit the CAP Web site to access the latest news and information about proficiency testing (PT) at

www.cap.org. Click on the Accreditation and Laboratory

Improvement tab and choose the2009 Surveys catalog. The new

online version of the catalogallows you to search by analyte,survey name, or program code.

Now you can print the page,chapter, or whole catalog!

Visit the CAP Web site to stay informed of future updates and

new product additions!

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2009 Surveys & Anatomic Pathology Education Programs

www.cap.org

Surveys & Anatomic Pathology Education ProgramsNew DevelopmentsDISCIPLINE SURVEY/PROGRAM PAGE(S)

The following Q-Tracks/QProbes are new for 2009:

Utilization of STAT Test Priority QP091 35

Monitoring of Outpatient Orders Requiring Clarification QP092 36

Quality of Transfusion Documentation QP093 37

Mislabeling Rate of Specimens, Blocks, and Slides in Surgical Pathology QP094 37

CHEMISTRY

General, Urine, and Special Chemistry

Lipoprotein-associated phospholipase A2 Survey is now available PLA 53

Neonatal Bilirubin, 2 challenges, is now available NB2 63

Urine Bence Jones Proteins is now available UBJP 56

TOXICOLOGY

Acetaminophen is now available UDS, UDS6, UDSM 79

Buprenorphine is now available UDS, UDS6, UDSM 79

Methadone metabolite (EDPP) is now available UDS, UDS6, UDSM 79

COAGULATION

Heparin Induced Thrombocytopenia Survey is now available CGS5 125

MICROBIOLOGY

Stool Pathogens Survey is now available SP 136

Rapid Norovirus Survey is now available SP1 136

Molecular Microbiology

Methicillin Resistant Staphylococcus aureus screen,5 challenges, is now availiable MRS5 133

Nucleic Acid Amplification, Organisms Survey is now available IDO 149

Nucleic Acid Amplification, Viruses Survey is now available ID1, ID1T 149

Nucleic Acid Amplification, Respiratory Survey is now available ID2 150

S H I P P I N G C A L E N D A RDownload and customize your 2009 Surveys & Anatomic Pathology Education Programs Shipping Calendar by using the Microsoft®

Excel spreadsheet format on the CAP Web site at www.cap.org/apps/docs/proficiency_testing/shipping.html

2 New Developments

College of American Pathologists

800-323-4040 Option 1 for Customer Contact Center

DISCIPLINE SURVEY/PROGRAM PAGE(S)

TRANSFUSION MEDICINE

Transfusion Medicine

Bacterial Detection in Platelets Survey is now available BDP 171

Transfusion-Transmitted Viruses

Viral Markers, Series 5 – Anti-HAV, IgM and Anti-HBc, IgM Surveyis now available VM5 174

IMMUNOLOGY

Total Hemolytic Complement is now available CH50 152

Flow Cytometry, Interpretation only FL5 160

ANATOMIC PATHOLOGY

Online Digital Slide Program in Dermatopathologyis now available DPATH, DPATH1 195

Progesterone Receptor (PR) Tissue Microarray Survey is now available PM2 199

New Developments 3


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2008 Survey Code 2008 Survey(s) Name Suggested 2009 Survey(s) Page(s)

VM1 AABB/CAP Viral Markers, Series 1 VM1, VM5 172, 174

ID Nucleic Acid Amplification IDO, ID1, ID1T, ID2 149, 150

IDV Nucleic Acid Amplification ID1, ID1T, ID2 149, 150

RAP Renin, Aldosterone, and PTH Assays ING, RAP 71

2009 Surveys Reconfigured

Former Survey Code Former Product/Survey Suggested 2009 Survey(s) Page(s)A1 Basic Combination CGL, CM/CMP, C3 123, 115, 47

A1N Basic Combination, SI Unit Reporting CGL, CM/CMP, C3 123, 115, 47

CGW Chemistry General, Waived C3 47

CN3 General Chemistry, SI Unit Reporting C3 47

KN Ligand Assay (General), SI Unit Reporting K 67

MK1 Immunohistochemistry, Addl Pathologist Not Applicable

WP5 Whole Blood Coagulation Not Applicable

2008 Discontinued Products

Survey Analyte(s)N Albumin, beta 2-microglobulin, catecholamines, oxalate, porphobilinogen

CARMI, CRTI LD1, isoenzymes, immunochemical; CK-MB, immunochemical (U/L); CK-MB, qualitative

GH2 Glycohemoglobin (GHb)

HBF F cell value

Q Creatinine, Lactate

Analytes Not Offered for 2009

4 Product Fulfillment Groups



Name Code Surveys IncludedAntibody Titer ABT ABT, ABT1, ABT2Critical Care Aqueous Blood Gas AQ AQ, AQ2Autopsy Pathology AU AU, AU1Autopsy Pathology CD-ROM AUCD AUCD, AUCD1Chemistry C C1, C3, C3X, C7, CZ, CZX, CZ2, CZ2XCardiac CAR CARM, CRT, TRPCardiac Markers with Isoenzymes CARI CARMI, CRTIBasic Coagulation CGL CGL, CGDFClinical Microscopy CM CM, CMP, CMM, CMMP, DSC, GOCB, OCBCardiac Risk CR HMS, hsCRPCrystals CRS BFC, URCImmunosuppressive Drugs CSM CS, MPAFISH for Paraffin-Embedded Tissue CYP CYJ, CYK, CYLOnline Digital Slide Program in Dermatopathology DPATH DPATH, DPATH1Electrophoresis ELP LPE, SPE, UBJPHematology Automated Differentials FH1-4, 6, 8-10 Series FHX FHX, FHXK, FHXPForensic Identity FID FID, FIDMFlow Cytometry FL FL, FL1, FL2Online Digital Slide Program in Fine Needle Aspiration FNA FNA, FNA1FBR/CAP Maternal Screening FP FP, FPXForensic Pathology FR FR, FR1Gastrointestinal and Hepatic Disease Serologies GIH APC, H, LKMHepatitis Viral Load HVL HCVN, HCV2, HBVLBasic Hematology HE HE, HEK, HEPHIV Viral Load HIV HIV, HV2HLA Serologic Typing HL ABO, HLAS, HLAS1Human Papillomavirus (High Risk) CHPV CHPVD, CHPVJ, CHPVK, CHPVMIn Situ Hybridization ISH ISH, ISH2Transfusion Medicine J J, JE1Ligands K K, KK, FOLBlood Cell Identification KP BCK, BCPBlood Gas/Critical Care Calibration Verification/Linearity LN13 LN13, LN13CLung Maturity LM LM, LM1

Multiple Product PFGs

Product Fulfillment Groups (PFGs)The following product fulfillment table identifies Surveys specific to a particular discipline or subdiscipline, which havebeen grouped into the same shipping configuration. As a result, you will receive fewer result forms, evaluations, andparticipant summary reports to complete and review. Your shipments will include specimens only for the products youhave ordered.

continued on next page

Product Fulfillment Groups 5


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Name Code Surveys IncludedNucleic Acid Amplification, Viruses ID1 ID1, ID1TMolecular Genetics MGL MGL1, MGL2, MGL3, MGL4, MGL5Molecular Oncology MO MO, MO2, MO3HLA Crossmatching, Antibody MX1 MX1B, MX1C, MX1EScreen, and Antibody Identification (Class I)HLA Crossmatching, Antibody MX2 MX2B, MX2C, MX2EScreen, and Antibody Identification (Class II)Interlab Comparison Program in NGC NGC, NGC1Non-Gynecologic CytopathNeuropathology NP NP, NP1Blood Gas OQ O, QParasitology P P, P3, P4, P5Interlab Comparison Program in PAPCED1 PAPCE1, APAPCE1Gynecologic Cytopath, ConventionalInterlab Comparison Program in Gynecologic PAPJED1 PAPJE1, APAPJE1Cytopath, Conventional, SurePath™ and ThinPrep® slidesInterlab Comparison Program in Gynecologic PAPKED1 PAPKE1, APAPKE1Cytopath and SurePath™ slidesInterlab Comparison Program in Gynecologic PAPMED1 PAPME1, APAPME1Cytopath and ThinPrep® slidesPlatelet Aggregation Study PF PF, PF1Paroxysmal Nocturnal Hemoglobinuria PNH PNH, PNHWPerformance Improvement Program PIP PIP, PIP1in Surgical PathologyRheumatic Disease Special Serologies RDS CCP, RDSDiagnostic Immunology S ANA, ASO, CRP, HCG, IG, IGX, IL,

IM, RF, RFX, RUB, RUBXImmunology (Special) S2 S2, S4, S5Special Clinical Microscopy SCM SCM1, SCM2Semen Analysis SEM ASA, SC, SC1, SM, SVSperm Morphology and Motility on CD-ROM SPCD SMCD, SM1CDStool Pathogens SP SP, SP1Sweat Analysis SW SW1, SW2, SW3, SW4Tumor Markers TM TM, TMXOnline Virtual Biopsy Program VBP VBP, VBP1Viral Markers VM VM1, VM2, VM3, VM4, VM5Virology Antibody Detection VR3 VR3, VR3MVaginal Screen Antigen Detection VS VS, VS1Ligands—Special Y BGS, BU, DY, EPO, ING, RAP, Y, YYTherapeutic Drug Monitoring (Special) ZT ZT, ZZT

Multiple Product PFGs, continued

6 Icon Legend



Icon LegendIn addition to information noted in the Product Information section of each product description, the CAP is also usingicons to highlight new products or analytes, changes to current products, and related products. The following is anexplanation of the icons used throughout the catalog.

New ProgramThe CAP continues to be on the forefront of emerging technologies by providing you with proficiency testingand educational programs for routine and esoteric analytes. The New Program icon indicates newlyintroduced programs.

New Analyte or ProcedureThe CAP continues to review all currently offered programs to provide the most appropriate analytes andprocedures available. As new analytes or methods are developed, they will be added to currently availableprograms. The NEW Analyte or Procedure icon indicates newly introduced analytes or methods withincurrently offered programs.

EducationThe CAP has taken education to the next dimension. The Education icons indicate programs that provideAMA PRA Category 1 Credits™ for Continuing Medical Education (CME) or continuing education (CE)credits for nonphysicians.

Etiologic IconAll bacterial and viral strains used in PT challenges have been classified by the Centers for Disease Controland Prevention (CDC) as not greater than a Biosafety Level 2.

Reconfigured

As laboratory testing patterns and services change, the CAP will continue to modify programs to best meetlaboratory needs. The Reconfigured icon indicates programs whose contents have been modified into newprogram offerings.

LN Express

LN Express allows you to access your time critical evaluation of Linearity Reports within four days of receipt ofyour input results on e-Lab Solutions. Look for the LN Express symbol next to those products supported by thiscomplimentary service.

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2CUSTOMER SUPPORT ANDORDERING INFORMATION

Customer Support ..................................................................7

Ordering Instructions, Terms and Conditions..............................8

Non-Continental US and International Customers ....................11

! Special Product Requirements ..........................................12

Surveys Programs Cosponsors ..............................................17

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Contact Center Hours(7:00 AM–5:30 PM CT Monday–Friday)Extended customer support hours ensure coverage for all time zones. Call 800-323-4040 option 1 to speak with aCustomer Contact Center Representative.

Message ServiceThe CAP’s voice mail system allows you to leave a message from 5:30 PM to 7:00 AM CT. Your message receives priorityattention, with a response guaranteed by the next business day.

Laboratory Accident Hotline(800-443-3244)Accidental exposures while processing specimens from the CAP, including cuts and contamination of mucous membranesor non-intact skin, should be reported to the CAP hotline for evaluation and questions regarding prophylaxis. Please haveavailable the identification number of the relevant specimen.

Contact the CAP via the Web SiteYou can conveniently submit your request or question online via the CAP Web page. Log on to www.cap.org and click on“Contact Us” at the top of the home page.

Program CertificatesAt the completion of the program year, participating laboratories will receive a program certificate that recognizes eachinstitution’s participation in CAP Surveys & Anatomic Pathology Education Programs and its commitment to patient care.Certificates are signed by the CAP President and are suitable for framing.

e-LAB SolutionsTM

"Join over 10,000 laboratories that are now using the CAP's online proficiency testing service. Using e-LAB Solutions,your laboratory can enter and view proficiency testing results online. You can also view or print prior copies of thefollowing documents: evaluations, kit instructions and result form pages. The site contains a User's Guide that will helpwalk you through the process. By opting in, your laboratory will also receive important e-mail notifications regardingproficiency testing events (ie, e-mail regarding non-receipt of result forms). Go ahead, give it a try!"

Customer SupportThe Customer Contact Center supports the mission of the College of American Pathologists; strives toprovide exceptional service to all customers; demonstrates courtesy, accuracy, and professionalism; andmakes a positive impact on health care.

Has your laboratory had a change in contact information such astelephone number, e-mail address, fax number, or address?

Please contact a CAP Customer Contact Center Representative at 800-323-4040 option 1to update your account information.

8 Ordering Instructions, Terms and Conditions



Order DeadlinePlease order early. Limited quantities are available for some products. To ensure full participation, please order byDecember 1, 2008. Orders received after this date will be processed by date of receipt and prorated per productavailability.

Renewal OrdersFor current customers, products ordered during the current subscription year are printed on your order renewal form.Please review all notes and refer to the catalog for product changes. Completed forms with payment information may befaxed to Customer Data Management at 847-832-8168. After your order is processed, an Order Confirmation will bemailed. This confirmation will reflect your order as processed and provides you the opportunity to make changes.

CAP Number and CLIA NumberPlease use your CAP number when making inquiries about your order. If you are a new customer, a CAP number will beassigned and will appear on your Order Confirmation report. US customers should confirm or provide the laboratory’sCLIA identification number, which is assigned by the Centers for Medicare & Medicaid Services (CMS) and can beobtained from your laboratory director. If you do not have a CLIA ID number, contact your CMS Regional Office. You maysubmit your order pending assignment of this number; forward the number to CAP once assigned. An order form isprovided in the back of the catalog for your convenience.

PricesPrices are in US dollars. Prices are exclusive of sales and value added taxes, duties, and other applicable charges. Pricesare subject to change without notice.

PaymentPlease fill out the payment section of the order form. To avoid delay in the processing of your order, one of the followingmethods of payment is REQUIRED:

! Check payable to the College of American Pathologists in US dollars

! Credit Card number, expiration date, cardholder’s name and authorized signature

! Purchase Order number—Please contact the CAP Customer Contact Center if your companyrequires a price quote prior to processing a purchase order.

! Letter of authorization—If your institution does not use a PO system, a signed letter ofauthorization on institutional letterhead will be accepted.

Orders that are processed by October 31, 2008, will have payment terms extended until December 1, 2008. For ordersprocessed after November 1, 2008, terms are net 30 from the date of the invoice.

Ordering Instructions, Terms and ConditionsTo ensure accurate and timely order placement, please:

! Return AALLLL pages of your renewal order form, including payment information.! Please print legibly and follow all instructions for adding or canceling products; the order

form is a scanned document.

Ordering Instructions, Terms and Conditions 9


www.cap.org

Wire Transfer InformationPlease include all bank fees in your payment, as the CAP is not responsible for bank fees incurred while remittingpayment. Wire information should include your CAP number, account number, invoice number, and/or order number.Remit payment by wire transfer to:

Harris Bank • 311 West Monroe Street • Chicago, Illinois 60606 USA

Phone: 1-312-461-2121

Account Number: 223-733-7

ABA Number: 071000288

SWIFT #: HATRUS44

Tax InformationIf your institution is subject to sales tax, the appropriate tax for your locale will be assessed and added to your invoice.Please include applicable tax with your prepaid order. If you are not subject to sales tax and have not notified theCAP, please enclose your tax-exempt certificate with your order form. The CAP Federal Tax Identification Number is36-2118323.

Additions, CancellationsThe CAP will make every attempt to accommodate orders received after December 1, depending upon the shippingschedule and specimen availability. Due to vendor commitments, cancellations must be received no later than sixweeks prior to the ship date to receive credit for canceled products. The CAP reserves the right to change thepublished prices and ship dates for products in this catalog.

Use of ProductsAll products are intended for proficiency testing (PT) use only. PT samples, their progeny, unmodified derivatives, ormodifications thereof may not be transferred or incorporated into a product intended for sale. PT samples, their progeny,unmodified derivatives, or modifications thereof, reagents, and disposable equipment used in proficiency testing, whendisposed of, should be autoclaved or incinerated and disposed of as hazardous waste. All directions concerning use ofthe product are intended as guidance only. No license is either granted or implied by the sale of any product.

Biohazard InformationAll bacterial and viral strains used in PT challenges have been classified by the Centers for Disease Control and Prevention(CDC) as not greater than a Biosafety Level 2. A full description of Biosafety Level 2 handling requirements, as defined bythe CDC Office of Health and Safety in Biosafety in Microbiological and Biomedical Laboratories, can be found at thefollowing Web site: www.cdc.gov/od/ohs/biosfty/bmbl5/bmbl5toc.htm.

If your laboratory is not Biosafety Level 2 compliant, please contact the CAP Customer Contact Center at800-323-4040 option 1 for further information regarding appropriate fulfillment of PT requirements.

Biohazard Warning StatementsAll Surveys include a biohazard warning statement appropriate for handling of the material included in the Surveys.Surveys that do not include etiologic agents are still expected to be handled in keeping with CDC universal precautionsand OSHA blood borne pathogen rules.

10 Ordering Instructions, Terms and Conditions



ShippingAll shipments are made Freight On Board (FOB), origin Delivered Duty Unpaid (DDU).The CAP is not liable for loss ordamage caused by force majeure. It is important that you provide a complete address, telephone number, fax number, e-mail address, and contact name on your order form. (Post Office box numbers are not an acceptable address for product shipments.)

Most proficiency testing program shipments will be sent via overnight, two-day, or International Priority Express service.

CAPTRAKer SM E-mailThe CAP has introduced a new service called CAPTRAKer, an electronic PT kit shipment-tracking program. We are nowproviding the ability for your lab to locate your PT kit in an instant! Watch your inbox for CAPTRAKer e-mails alerting youof product shipments. A link to the carrier tracking information will be embedded in the e-mail. To initiate the receipt ofthis notification, please send your name, account number, and e-mail address to [email protected].

Prelicensure/ Reinstatement Service The CAP provides proficiency testing (PT) samples to laboratories that may need to perform prelicensure testing beforebeginning patient testing and/or reinstatement testing due to PT failures.

PT samples with limited stability will not be available for prelicensure/reinstatement testing. Please call the CAPCustomer Contact Center for costs and availability.

A Reinstatement Evaluation will be provided upon submission of results to CAP.

CMS ReportingThe College of American Pathologists is required to submit proficiency-testing (PT) results to the Centers for Medicareand Medicaid Services (CMS) for all laboratories providing a CLIA identification number. Your reporting preferences areoutlined on the CMS Analyte Reportng Selections document. If a laboratory does not notify CAP in advance that theyhave discontinued testing of a regulated analyte, a score of zero will be given. In order to avoid any penalties, analyteslisted on this report for which you do not perform tesing must be noted to ensure appropriate reporting in the future.Contact our Customer Contact Center at 800-323-4040 option 1 or go to www.cap.org under the Accreditation andLaboratory Improvement tab for more information.

PT ReferralProficiency-testing referral has come under greater scrutiny from inspectors for the Centers for Medicare and MedicaidServices (CMS). The CAP’s Proficiency Testing Program reminds participants that per CLIA ‘88, laboratories must test thePT specimens it receives in the same manner as it tests patient specimens—the specimens must be tested with the laboratory’s regular workload, using the laboratory’s routine methods, and the same number of times itroutinely tests patient specimens. However, laboratories must not communicate results, share proficiency testing specimens, or refer proficiency testing specimens to a laboratory with a different CLIA numberfor tests not on the laboratory’s menu even if referral for testing is routinely performed for patient specimens.

PermitsMany countries require import permits or certificates of origin for customs clearance (regardless of hazard status of product).Please request information from local authorities to determine if any permits are required. Import permits are obtained byyou the customer and are forwarded to the CAP for inclusion with the product shipment. In addition, please provide thesedocuments to your broker or the local carrier broker. Products with hazardous/dangerous materials may be subject to specialpermits and additional charges. Please submit all permits a minimum of six weeks prior to the stated productship date to ensure on time shipment. Products will not ship without required documentation.

Current Canadian regulations require that Canadian laboratories obtain import permits to import animal and humanpathogens. This regulation applies to CAP Surveys. It is important that you obtain permits from the Public Health Agency ofCanada for all infectious Surveys and a second permit from the Canadian Food Inspection Agency.

Non-Continental US and International Customers 11


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Non-Continental US and International Customers

Product Code Product NameBAS Bacterial Antigen DetectionBDP Bacterial Detection in PlateletsBCS Blood CultureCBT Cord Blood TestingD BacteriologyD1 Throat CultureD2 Urine CultureD3 GC CultureD4 Bacteriology – LimitedD7 Throat/Urine CultureE MycobacteriologyE1 Mycobacteriology – LimitedF MycologyF1 YeastHPS Helicobacter pylori Antigen, stoolIDO Nucleic Acid Amplification, OrganismsID1, ID1T Nucleic Acid Amplification, VirusesID2 Nucleic Acid Amplification, RespiratoryLPX Laboratory Preparedness ExerciseMRS Methicillin Resistant Staphylococcus aureus ScreenMRS5 Methicillin Resistant Staphylococcus aureus Screen, 5 ChallengesSCP Stem Cell ProcessingSP Stool PathogenST Shiga ToxinVR1 Virology CultureVR4 Virology Antigen Detection (non-IFA)VS Vaginitis Screen – Affirm VP III

Products Requiring Canadian Import Permits

The state of Hawaii also requires import permits. You may obtain an import permit by contacting the Plant QuarantineBranch of the State of Hawaii Department of Agriculture. You will need to complete Form PQ-7 to obtain the import permit.

12 Non-Continental US and International Customers



Special Shipping and Handling ChargesAn additional fee in US dollars is charged for each product sent outside the United States to cover shipping costs andhandling requirements. All additional fees, duties, and taxes not reflected in CAP list prices may be imposed on orders;customers should check with the local customs office regarding these charges. Note: No refund is issued for this fee if any of the shipments have been mailed.

If a special or hazardous material (E, E1 products only) shipping and handling charge is required for your order, theadditional fee referenced above will be waived. The calculation of the hazardous material shipping and handling charge isbased upon the method of product delivery designated for your country. If the product is shipped via freight forwarder,the charge is $330 USD.** If the product is shipped airport-to-airport, the charge is $195 USD.** If the product isshipped door-to-door, the charge is $85 USD.**

Product Code Product NameBDP Bacterial Detection in PlateletsBCS Blood CultureCBT Cord Blood TestingD BacteriologyD1 Throat CultureD2 Urine CultureD3 GC CultureD4 Bacteriology – LimitedD7 Throat/Urine CultureE MycobacteriologyE1 Mycobacteriology – LimitedF MycologyF1 YeastHC4 Herpes CultureHC5 Chlamydia trachomatis/Neisseria gonorrhoeae by DNA ProbeHC6 Chlamydia trachomatis/Neisseria gonorrhoeae by Nucleic Acid Amplification (NAA)HPS Helicobacter pylori Antigen, stoolI Instrumentation*IDO Nucleic Acid Amplification, OrganismsLPX Laboratory Preparedness ExerciseMRS Methicillin Resistant Staphylococcus aureus ScreenMRS5 Methicillin Resistant Staphylococcus aureus Screen, 5 ChallengesSCP Stem Cell ProcessingSP Stool PathogenST Shiga ToxinVR1 Virology CultureVS/VS1 Vaginitis Screen Antigen Detection

Products With Hazardous Materials

The Surveys listed below contain hazardous materials and may require special permits and additional charges:

*WARNING: The Instrumentation (I) Survey samples contain substances which may be corrosive, toxic, environmental hazards, and irritants.

**per shipment



www.cap.org

The following paper/online products are NOT subject to shipping and handling charges:

Carrier InformationThe following shipments are sent via Federal Express:

CAP recommends you contact your in-country carrier’s site and discuss delivery. It may be necessary to complete a powerof attorney (POA) or identify your broker for customs clearance. Establishing an account with the appropriate carrier(s)will expedite delivery by allowing the carrier to charge duties and taxes direct to your account with them.

In some limited instances CAP must use a freight forwarder to ship products to your destination. Please respond promptlyto requests from freight forwarders to coordinate the in-country delivery of your package. If your organization is specifi-cally requesting shipment via a freight forwarder at your expense, be sure to provide CAP with both your final shipmentaddress and the freight forwarder’s US domestic address. When using a freight forwarder, permits must still be providedto the CAP.

CAP products are shipped door-to-door service whenever possible. In instances where your country doesnot allow delivery to your door, CAP can arrange shipment only to an airport. In these instances the carrier will notify you when a product has been cleared and is ready for pickup. You must take action atthat point to pick up your shipments or to receive them via an in-country courier if allowed.

Product Code Product NameAPAPCPT, APAPKPT, APAPMPT, APAPJPT Gynecologic Cytology Program, each additional pathologist or

cytotechnologistAPAPCE1, APAPKE1, APAPJE1, APAPME1 Interlaboratory Comparison Program in Gynecolgic Cytopathology, additional pathologist or cytotechnologistAU1, AUCD1 Autopsy Pathology, additional pathologistDPATH1 Online Digital Slide Program in Dermatopathology,

additional pathologistFNA1 Online Digital Slide Program in Fine-Needle Aspiration, additional

pathologist or cytotechnologistFR1 Forensic Pathology, additional pathologistNP1 Neuropathology, additional pathologistNGC1 Interlaboratory Comparison Program in Non-Gynecologic

Cytopathology, each additional pathologist or cytotechnologistPIP1 Performance Improvement Program, additional pathologistAll Q-Tracks, Q-Probes, and LMIPRRS, RRS2, RRS3, RRS4 Reference Range ServicesVBP, VBP1 Online Virtual Biopsy Program

No Shipping and Handling Charges

E MycobacteriologyE1 Mycobacteriology (Limited)JAT Transfusion Medicine Automated Testing

Shipment Via Federal Express




Special RequirementsDiscuss any special shipping requirements you have with the CAP Customer Contact Center staff. This may includerequests to receive an advance copy of your commercial invoice or a request to ship PT via a specific carrier using yourorganization’s account with that carrier. All requests for special shipping arrangements must be received at the CAP aminimum of six weeks prior to the stated product ship date.

Product Stability Some products have limited stability and may be difficult to transport to some locations. These products include thefollowing:

Please note that replacements will not be available for products with limited stability. Survey materials that areliquid are shipped with frozen cold packs or dry ice and need to be kept cold as much as possible. If transportation toyour location does not allow for these conditions to be met, replacements will not be available.

If the CAP accredits your international laboratory, please review options for addressing issues with material instabilitywith the CAP Laboratory Accreditation Program staff.

Customers shall be liable for all costs and expenses related to the return of shipments to the CAP or its designated packagers, if the reason for such return is late product cancellation, shipment refusal, or invalid ship-to address.

B27 HLA-B27 TypingCARM, CARMI, CRTI Cardiac Markers with IsoenzymesCBT Cord Blood TestingEPO ErythropoietinFL3 Flow Cytometry-ImmunophenotypicGH2 GlycohemoglobinJAT Transfusion Medicine-AutomatedHLAS HLA Serologic Typing (Class I and II)HLAS1 HLA Serologic Typing (Class I only)LN15 Glycohemoglobin Calibration V/LMX1B Crossmatching, Antibody screen and identification (Class I) basicMX1C Crossmatching, Antibody screen and identification (Class I) comprehensiveMX2B Crossmatching, Antibody screen and identification (Class II) basicMX2C Crossmatching, Antibody screen and identification (Class II) comprehensivePNHW Flow Cytometry-Immunophenotypic Characterization of Paroxysmal Nocturnal

HemoglobinuriaSCP Stem Cell Processing

Products With Less Than 10 Days Stability



www.cap.org

Dry IceSome shipments are packed on dry ice to maintain product stability. Dry ice shipments are shipped as UN1845 dangerousgoods shipments. There may not be any dry ice present when you open your kit due to sublimation. This is not an indica-tion that the product has spoiled. If your country does not allow dry ice shipments, your Surveys will be packaged withcool packs that may not be as effective in maintaining a cool environment. Follow the kit storage instructions as soon aspossible.

Duties and TaxesDuties and import taxes imposed by countries outside of the United States are the responsibility of the customer andcannot be waived by the CAP. Shipments are processed Delivered Duty Unpaid (DDU).

Commercial InvoiceCommercial invoices are placed on packages as required by international shipping conventions. The commercial invoiceis an official transaction record between an exporter and an importer. The commercial invoice is the form customs officials use to clear your shipment.

The invoice total listed on the commercial invoice is not the amount due to CAP or your country. The invoice total is listedfor the purpose of computing duties and taxes only.

Tax Identification NumberIf required by your country, please provide the CAP with your national tax identification number for inclusion on thecommercial invoice.

Product Code Product NameABL Accuracy Based Lipid SurveyBGL ACMG/CAP Biochemical GeneticsBNP B-type Natriutetic Peptides SurveyCFS Commutable Frozen SerumC1, C3, C3X, CZ, CZX, CZ2, CZ2X, CZVM, Z General Chemistry and Therapeutic Drug Monitoring CARM, CARMI, CRT, CRTI, TRP Cardiac MarkersHBVL, HCV2, HCVN Hepatitis Viral LoadHIV, HV2 HIV Viral LoadK, KK, Y, YY Ligand AssaysLN1, LN1ER Chemistry Calibration Verification/Linearity LN2, LN2ER, LN2VM, LN2ERVM Chemistry/Lipid/Enzyme Calibration Verification/LinearityLN25 Troponin I Calibration Verification/LinearityLN27 Troponin T Calibration Verification/LinearityLN30 B-type Natriuretic Peptides Calibration Verification/LinearityNB, NB2 Neonatal Bilirubin MO Molecular OncologyMRD Minimal Residual DiseaseSARC Sarcoma Translocation

Products Shipped on Dry Ice




CAPTRAKer SM E-mailThe CAP has introduced a new service called CAPTRAKer SM, an electronic PT kit shipment-tracking program. We are nowproviding the ability for your lab to locate your PT kit in an instant! Watch your inbox for CAPTRAKer SM e-mails alertingyou of product shipments. A link to the carrier tracking information will be embedded in the e-mail. To initiate thereceipt of this notification, please send your name, account number, and e-mail address to [email protected].

Carrier ContactCarriers or customs officials may attempt to contact you, if there are issues regarding clearing your shipment. Pleaserespond to these requests for additional information. Contact the CAP if you need additional product information to expedite clearance.

To submit permits Fax: 847-832-8168E-mail: [email protected]

To discuss special shipping needs Contact Center: 847-832-7000 option 1E-mail: [email protected]

To initiate CAPTRAKer SM e-mail Contact Center: 847-832-7000 option 1E-mail: [email protected]

To discuss stability issues with Laboratory Accreditation: 847-832-7000 option 2Laboratory Accreditation E-mail: [email protected]

To submit a PT order Fax: 847-832-8168

CAP Contact Information

Surveys Programs Cosponsors 17


www.cap.org

The CAP, together with five respected scientific organizations, is committed to the development of the highest qualitySurveys for specialty disciplines. The scientific expertise that results from the teaming of CAP pathologist experts and scientists from cosponsoring organizations is extraordinary and allows for the development of quality assurance tools that reflect newly emerging technology and state-of-the-art laboratory medicine.

Our Distinguished CosponsorsAABB AABBPAR, PARF AABB/CAP Parentage TestingVM1 AABB/CAP Viral Markers Series 1VM2 AABB/CAP Viral Markers Series 2VM3 AABB/CAP Viral Markers Series 3VM5 AABB/CAP Viral Markers Series 5

AACC American Association for Clinical ChemistryAL1 AACC/CAP Whole Blood Alcohol/VolatilesAL2 AACC/CAP Serum Alcohol/VolatilesBL AACC/CAP Blood LeadCS AACC/CAP Immunosuppressive DrugsUDC AACC/CAP Forensic Urine Drug Testing (Confirmatory)UDS AACC/CAP Urine Drug Testing (Screening)UDS6 AACC/CAP Urine Drug Testing Screen (six challenge)

ACMG American College of Medical Genetics BGL ACMG/CAP Biochemical GeneticsCY ACMG/CAP CytogeneticsCYCGH ACMG/CAP Microarray—Genomic Copy Number AssayCYF ACMG/CAP FISH for Constitutional and Hematologic DisordersCYH ACMG/CAP FISH for Paraffin-Embedded Tissue—Breast CancerCYI ACMG/CAP FISH for Urothelial Carcinoma CYJ ACMG/CAP FISH for Paraffin-Embedded Tissue—GliomaCYK ACMG/CAP FISH for Paraffin-Embedded Tissue—Sarcoma CYL ACMG/CAP FISH for Paraffin-Embedded Tissue—Lymphoma MGL1 ACMG/CAP Molecular GeneticsMGL2 ACMG/CAP Molecular GeneticsMGL3 ACMG/CAP Molecular GeneticsMGL4 ACMG/CAP Molecular GeneticsMGL5 ACMG/CAP Molecular Genetics

FBR Foundation for Blood ResearchFP, FPX FBR/CAP Maternal Screening

NSH National Society for HistotechnologyHQIP NSH/CAP HistoQIP

Surveys Programs Cosponsors



Survey Binder InformationTo provide you with an easy way by which to store yourprogram materials, for every seven (7) Survey Programsyou order, one three-ring binder will be sent to you at nocharge. There is no need to order the binders as they willbe shipped automatically upon placement of your order.

Additional binders may be purchased for $10 each usingthe 2009 order form; see Survey Binder-product code“CAPBIND.”

If you have questions regarding the binders or any otherinquiry, please e-mail CAP at [email protected] orcall a Customer Contact Center Representative at 800-323-4040 option 1.

17 Survey Programs

Free three-ring binder

Order

Receive

3CONTINUING EDUCATION

Cont

inui

ngEd

ucat

ion

CAP Continuing EducationOnline, slide-based, and paper-based education activities make it easyfor you and your staff to earn continuing education credits withoutleaving your laboratory, saving time and money.

These educational activities allow you to:

! Keep your knowledge and skills up-to-date

! Earn CME/CE credits

! Learn without leaving your lab

! Track CME/CE credits easily with the CAP’s free online transcript

CAP education is developed by a team of renowned pathologists and contentexperts who work with the CAP’s professional learning specialists to give you clear,relevant, and high-quality education.

CME/CE

www.cap.org

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Continuing Education Opportunities 19


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Continuing Education Opportunities

Surveys Education ProgramsWhen your lab participates in Surveys, every member of your team can enroll in education activities and earn CE at noadditional charge. Each staff member simply establishes a free Web account, completes a reading provided in theParticipant Summary or Final Critique, and answers online learning assessment questions. Surveys education activities areavailable for six months. For information on upcoming topics, visit www.cap.org, click the Education Programs tab, andthen click Surveys.

Quality Management ProgramsContinuing education credit is available with select quality management tools. Continuing education credit will be appliedtoward the year in which the activity is completed. For more information on available continuing education credit forLMIP, Q-PROBES, and Q-TRACKS, call the CAP Customer Contact Center at 800-323-4040 option 1.

For LMIP, each quarter one individual at each participating institution can earn education credit upon completion ofthe paper-based education activity. New for Q-PROBES and Q-TRACKS, multiple laboratory staff can earn continuingeducation credit (CME/CE) by reading the Final Critique and answering the online learning assessment questions. Formore information, visit www.cap.org, click on the Accreditation and Laboratory Improvement tab, and then click AboutQ-TRACKS, About Q-PROBES, or About LMIP under Quality Assurance Programs.

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Product Maximum AMA PRA CME Maximum CEProgram Name Code Category 1 Credits™ Credits/Hours Pages

LMIP® LMB 12 12 38–39Q-PROBES™ QP091, 92, 93, 94 4 4 34–37Q-TRACKS® QT1-5, QT7-10, QT15-17 48 48 27–33

Quality Management Programs

20 Continuing Education Opportunities



Anatomic Pathology Education ProgramsMany of the CAP’s Anatomic Pathology Education Programs include CME/CE credit. These case-based programs mayinclude glass slides, photomicrographs, and/or CD-ROMs. Participants review the slides, images, clinical background orreference information, then select an appropriate diagnosis and answer learning assessment questions. Target responsesare included in the original mailing.

* The NGC and PAP programs contain online components using virtual microscopy. Two of the possible CME/CEcredits in each program relate to the online components.

Maximum Maximum CEProduct AMA PRA CME Credits/

Program Name Code Category 1 Credits™ Hours PageAutopsy Pathology AU, AUCD, AU1, AUCD1 12 NA 206Forensic Pathology FR, FR1 12 NA 215Interlaboratory Comparison Program NGC, NGC1 18 18 202

in Non-Gynecologic Cytopathology*Neuropathology Program NP, NP1 8 NA 205Interlaboratory Comparison Program in PAPCE1, PAPJE1, 10 10 201

Gynecologic Cytopathology* PAPKE1, PAPME1Gynecologic Cytology PT Program PAPCPT, PAPJPT, 10 10 200

(including educational component) PAPKPT, PAPMPTPerformance Improvement Program in PIP, PIP1 40 NA 193

Surgical Pathology

Anatomic Pathology Education Programs

Cytotechnologists may apply credits/hours from the NGC Program toward required educational activities for the AmericanSociety of Cytopathology (ASC) Continuing Education Credit Program (CECC).

Cytotechnologists may apply credits/hours from the PAP Education Program toward required educational activities for theAmerican Society of Cytopathology (ASC) Continuing Education Credit Program (CECC) and the International Academy ofCytology.

Additionally, cytotechnologists may apply credits/hours from the PAP Education component of PAP PT toward requirededucational activities for the American Society of Cytopathology (ASC) Continuing Education Credit Program (CECC) andthe International Academy of Cytology.

MaximumProduct AMA PRA CME

Program Name Code Category 1 Credits™ PageOnline Virtual Biopsy Program VBP, VBP1 10 194Online Digital Slide Program in Fine-Needle Aspiration FNA, FNA1 5 203Online Digital Slide Program in Dermatopathology DPATH, DPATH1 5 195

Online Virtual Microscopy Education Programs

Continuing Education Opportunities 21


www.cap.org

Online Virtual Microscopy Education ProgramsThe CAP now offers new online education programs that use advanced imaging technology to present images from actualglass slides for a variety of sites and specimen types. This technology simulates a microscope, allowing you to scan theimage and use multiple magnifications to view the material. From the images and clinical information provided, youselect a diagnosis, answer learning assessment questions, and receive immediate feedback online.

The CAP’s online virtual microscopy education activities, which are compatible with both Windows and Macintoshoperating systems, require Internet access. The download speed and the appearance of the activity will vary depending onthe type and speed of your Internet connection, computer’s power, and browser. Higher speed connections will loadpages and images at a faster rate, and newer browser versions will enhance how the pages look on screen.

For optimal operation, the CAP recommends:

! CPU: Pentium II class or better

! Screen resolution of 1024 x 768

! Ethernet, ISDN, DSL, cable modem, or other high-speed digital connection

! Internet Explorer 5.0 or Firefox 2.0 and higher (other browsers may also work)

In addition, to use the virtual slide’s microscopy display in the VBP, NGC, DPATH, and PAP programs, you must have JavaVirtual Machine (JVM) software on your computer. If you do not already have a JVM on your computer, you can down-load and install a free JVM from the following site: java.com/en/download/manual.jsp.

If you don’t have administrator rights to install software on your computer, or cannot determine if your computer alreadyhas JVM software, please contact your technical support team for assistance.

AccreditationThe College of American Pathologists (CAP) is accredited by the Accreditation Council for Continuing Medical Education(ACCME) to provide continuing medical education for physicians.

CME Category 1The College of American Pathologists designates these educational activities for a maximum of the stated number of AMAPRA Category 1 Credits™. Physicians should claim only credit commensurate with the extent of their participation in theactivity.

CE (Continuing Education for nonphysicians)The College of American Pathologists designates these educational activities for a maximum of the stated number ofcredits/hours of continuing education. Each participant should claim only those credits/hours he/she spent in the activity.

These activities are acceptable to meet the continuing education requirements for the ASCP Board of Registry CertificationMaintenance Program.

These activities are approved for continuing education credit in the states of California and Florida.

Cytotechnologists may apply the credits from the PAPCE1/PAPJE1/PAPKE1/PAPME1, PAP PT and NGC programs toward therequired educational activities for the American Society for Cytopathology (ASC) Continuing Education Credit Program(CECC).

22 Competency Assessment Program



Competency Assessment ProgramCompetency Assessment Program is a systematic, online answer to competency assessment in yourlaboratory. With its comprehensive suite of powerful tools, the Competency Assessment Program isdesigned to help you meet CLIA-mandated competency assessment regulations.

Competency Assessment Program includes:

" Competency assessment courses with customized training and CE credit (See page 23)

" Reassessment courses

" A library of educational training courses (Pro Courses) with CE credit (See page 23)

" Instrument-specific observation checklists

" Course building and modifying tools

" Extensive management tracking and reporting

" Individual transcripts

How to Order Competency Assessment ProgramCompetency Assessment Program is designed for use by all personnel who, according to CLIA regulations, must havetheir competency assessed. This may include medical technologists, medical laboratory technicians, physicians, nurses,respiratory therapists, those performing point of care testing, and others. Your fee is based on the number of individualswho will be using Competency Assessment Program—that is, the number of people for whom you will be assessingcompetency, not the number of employees in your laboratory.

Your order is processed based on your CAP number. However, if your institution includes several small labs with separateCAP numbers, you may choose to enroll all users under one CAP number.

If you are renewing your Competency Assessment Program order, please note:The Order Codes for numbers of users per laboratory have changed. Order codes now allow a greater number ofemployees to be enrolled under one license.

More than 1,000 users: call 800-323-4040 option 1

Use the New Products page of the order form to enroll in Competency Assessment Program for your laboratory.

CE

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Number of Users Order Code Price1–50 CA0050 $59551–250 CA0250 $1,295251–1,000 CA1000 $1,995

Competency Assessment Program Order Breakdown

Competency Assessment Program 23


www.cap.org

Discipline January–June 2009 July–December 2009

Blood Banking/ Blood component preparation, storage, Pediatric and perinatal transfusionTransfusion Medicine and selection, part 2Chemistry Cardiac biomarkers Therapeutic drug monitoringHematology and Common coagulation tests Platelet counts, morphology,Coagulation and disordersImmunology Viral antigen and antibody detection Autoimmune disordersMicrobiology Fastidious and miscellaneous gram-negative bacilli Facultative and obligate anaerobic

bacteriaPhlebotomy/Specimen Pediatric collection, alternative sites, and Specimen collection for forensicProcessing difficult draws toxicology and workplace testing with

emphasis on urine drug collection andblood alcohol collection

Point of Care Testing Prothrombin time and ACT Point of care cardiac biomarkersSafety Emergency management: fire and electrical safety ErgonomicsUrinalysis Spinal fluid Semen analysis

Competency Assessment Program - Assessment Course Schedule

If you have questions or would like a brochure mailed to you, please contact the CAP at:[email protected]

800-323-4040 option 1

Discipline January–December 2009 July 2009–June 2010

Blood Banking/ Transfusion reactions Red blood cell components-Transfusion Medicine composition, storage, processing, and

selectionChemistry Lipids Endocrine functionHematology and Erythrocyte morphology White blood cell inclusionsCoagulationImmunology HIV Molecular methods for detection of

Neisseria gonorrhoeae and Chlamydiatrachomatis

Microbiology Enterobacteriaceae Non-fermentative gram-negative bacilliPhlebotomy/Specimen Collection and transport of specimens Routine venipuncture performanceProcessing for microbiologyPoint of Care Testing Provider performed microscopy and testing Point of care urine reagent strip testingSafety Hazardous chemicals Laboratory waste and spill managementUrinalysis Microscopic urinalysis, part 2 Body fluids, part 1–serous and synovial

fluids

Competency Assessment Program - Pro Course Schedule

It’s easy to administer and loaded with extra features—the most convenient and comprehensive laboratory competency assessment program available.

Customized training and CE credit through dozens of world-class courses

developed by the manufacturers

Course-building tools to modify and create your own courses and observation checklists

reporting to assign and track competency assessments

Get the detailsLearn more about Competency Assessment Program at 800-323-4040 option 1 or at our Web site cap.org. Click on the tab for Education Programs and then click on Competency Assessment Program.

As quality standards go up and your resources go down, how do you manage?

CAP 2009 Competency Assessment Program

CAP Competency Assessment Program— Your state-of-the-art approach to meeting CLIA mandates for the laboratory

4QUALITY MANAGEMENT TOOLS

New for 2009! Utilization of STAT Test Priority QP091

! Monitoring of Outpatient Orders Requiring Clarification QP092

! Quality of Transfusion Documentation QP093

! Mislabeling Rate of Specimens, Blocks, and Slides inSurgical Pathology QP094

Q-TRACKS® ........................................................................27! Clinical Pathology Monitors ........................................28

! Anatomic Pathology Monitor ........................................33

Q-PROBES™ ........................................................................34

LMIP® ................................................................................38

CAP LINKS™........................................................................40

Quality Management Tools Overview ....................................42

Quali ty Management Tools

Qua

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ualityManagementTools

The CAP’s comprehensive collection of QualityManagement Tools (QMT) strengthens yourknowledge of key laboratory processes, identifiesquality improvement opportunities, and provides theinformation you need for effective laboratory management:

! Q-TRACKS® Continuous Quality Monitors Program

! Q-PROBES™ In-Depth Quality Assurance Program

! LMIP® Laboratory Management Index Program

! CAP LINKS™ The Laboratory Integrated Knowledge Source

The CAP’s Quality Management Tools help you:

! Identify quality improvement opportunities and monitor progress over time

! Establish realistic goals for your laboratory using a set of customizedexternal benchmarks

! Demonstrate the ability to meet accreditation requirements

Integrate QMT into your daily activities to support your quality improvement initiatives!

www.cap.org

Quality Management Tools 25


26 Quality Management Tools



Q-PROBESUtilization of STAT Test Priority (QP091) ! ! ! !

Monitoring of Outpatient Orders RequiringClarification (QP092) ! ! ! ! ! !

Quality of Transfusion Documentation(QP093) ! ! !

Mislabeling Rate of Specimens, Blocks,and Slides in Surgical Pathology (QP094) ! ! !

Q-TRACKSPatient Identification Accuracy (QT1) ! ! ! !

Blood Culture Contamination (QT2) ! ! ! !

Laboratory Specimen Acceptability (QT3) ! ! !

In-Date Blood Product Wastage (QT4) ! ! !

Gynecologic Cytology Outcomes:Biopsy Correlation Performance (QT5) ! ! ! ! !

Satisfaction with Outpatient SpecimenCollection (QT7) ! ! !

Stat Test Turnaround Time Outliers (QT8) ! ! ! ! ! ! !

Inpatient Test Availability (QT9) ! ! ! ! ! !

Critical Values Reporting (QT10) ! ! ! !

Turnaround Time of Troponin (QT15) ! ! ! ! ! ! ! !

Corrected Results (QT16) ! ! ! ! ! !

Outpatient Order Entry Errors (QT17) ! ! ! !

Pre-

anal

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Ana

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Post-

anal

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Clin

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Turn

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Select the Q-PROBES andQ-TRACKS studies to support

your quality improvementinitiatives.

*CAP requires accredited laboratories to have a quality management plan that covers all areas of the laboratory and includesbenchmarking key measures of laboratory performance (GEN.13806-20364). The Joint Commission requires accredited hospitals toregularly collect and analyze performance data (PI.1.10, PI.2.10). CLIA requires laboratories to monitor, assess, and correctproblems identified in preanalytic, analytic, and postanalytic systems (§493.1249, §493.1289 §493.1299).

Q-PROBES and Q-TRACKSoffers a comprehensive collection of tools

to complement yourquality management program needs.*

Q-TRACKS 27


www.cap.org

A Program of Continuous Quality Measurement

Q-TRACKS

Q-TRACKS offers CME/CE credit for all laboratory staff each quarter to help youbuild a solid foundation of education and knowledge within your organization.

Observe performance trends over time to identify and monitor opportunities for quality improvement through quantitativequality measures. Q-TRACKS offers continuous quality monitoring with longitudinal tracking of performance and keyindicators for clinical and anatomic pathology.

Step 1:Establish realistic benchmarks by comparing yourlaboratory to others like you.

Step 2:Identify improvement opportunities.

Step 3:Monitor improvement over time toensure accurate diagnosis, patientsafety, and patient care.

Q-TRACKS 2007: QT3 - Laboratory Specimen AcceptabilityTrend Analysis Report: January-March

Q-TRACKS 2007: QT3 - Laboratory Specimen AcceptabilityExternal Comparison Report: January-March

(most like you)

28 Q-TRACKS



Blood Culture Contamination QT2

Patient Identification Accuracy QT1

Q-TRACKS Clinical Pathology Monitors

Monitor ObjectiveAssess the incidence of wristband errors within individual institutions, compare performance betweenparticipating institutions, and identify improvement opportunities.

Data CollectionOn six predetermined days per month, participants will monitor patient wristband identification for all phlebotomiesperformed at their institution. Phlebotomists will tally the total number of wristbands checked, the number of errorsfound, and the types of wristband error. This monitor includes all routinely wristbanded patients. (EmergencyDepartment patients are included only if the emergency department routinely applies wristbands to these patients.)

Performance Indicators Performance Breakdown• Wristband Error Rate (%) • Breakdown of Wristband Error Types (%)

Monitor ObjectiveDetermine the rate of blood culture contamination using standardized criteria for classifying contaminants.

Data CollectionOn a monthly basis, participants will tabulate the total number of blood cultures processed and the total numberof contaminated blood cultures. For the purposes of this study, participants will consider a blood culture to becontaminated if one or more of the following organisms are found in only one of a series of blood culture specimens:Coagulase-negative Staphylococcus; Micrococcus; Alpha-hemolytic (viridans) Streptococci; Propionibacteriumacnes; Corynebacterium sp. (diptheroids); or Bacillus sp. Optional institution-specific subgroups may be used totrack parameters that may affect contamination rates. Additionally, neonatal totals can be tabulated separately fromother blood cultures.

Performance Indicators• Total Contamination Rate (%) • Neonatal Contamination Rate (%) • Other Contamination Rate (%)

Despite advancements in blood culture practices and technology, false-positive blood culture results due to contaminantscontinue to be a critical problem. Blood culture contamination rate is associated with increased length of hospital stay,additional expense, and the administration of unnecessary antibiotics and is the primary indicator of preanalyticalperformance in microbiology. The CAP and other accrediting organizations require you to monitor and evaluate keyindicators of quality for improvement opportunities. Use this monitor to help you meet this requirement.

The proper identification of a patient is vital to reporting accurate laboratory results and meeting the Joint CommissionNational Patient Safety Goal #1: “Improve the accuracy of patient identification.” Since the majority of testing is performedaway from the patient, patient identification, labeling of specimens, and coordination with test requisitions must beconducted accurately and completely. By continuously monitoring for wristband errors, participants can promptly identifyand correct problems that may interfere with patient care services.CME/CE

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Input forms for quarterly data collection will be sent to participants approximately three weeks prior to the quarter.

CME/CE

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Q-TRACKS 29


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In-Date Blood Product Wastage QT4

Monitor ObjectiveIdentify and characterize unacceptable blood specimens that are submitted to the chemistry and hematology sectionsof the clinical laboratory for testing.

Data CollectionThis monitor includes all blood specimens submitted for testing to the chemistry and hematology departments of theclinical laboratory. Weekly tallies of the total number of specimens received, the number of rejected specimens, andthe primary reason each specimen was rejected will be recorded.

Performance Indicators Performance Breakdown• Specimen Rejection Rate (%) • Breakdown of Rejection Reasons (%)

Laboratory Specimen Acceptability QT3A substantial amount of rework, diagnostic and therapeutic delay, and patient inconvenience can result from specimenrejection. Patient redraws may be due to issues including unlabeled, mislabeled, and incompletely labeled specimens;clotted and/or hemolyzed specimens; and insufficient specimen quantity. By continuously monitoring specimenacceptability, collection, and transport, problems can be promptly identified and corrected, leading to improvedpatient care. Participation in this monitor can help satisfy the CAP’s checklist question GEN. 20348, “Are preanalyticprocesses monitored?”

Monitor ObjectiveCompare the rates of blood product wastage (i.e., units discarded in-date) in participating hospitals and track ratesof improvement over time.

Data CollectionOn a monthly basis, participants will use blood bank records to obtain information on the total number of unitstransfused for each type of blood component. Participants will track the number and type of blood units that arewasted in-date and the circumstances of wastage. The following types of blood components will be included: wholeblood (allogeneic); red blood cells (allogeneic); fresh frozen plasma; platelet concentrates; single donor platelets;and cryoprecipitate.

Performance Indicators Performance Breakdown• Overall Wastage Rate (%) • Breakdown of Wastage Reasons (%)• Wastage Rates by Blood Component Type(%)

Blood for transfusion is a precious resource. At a minimum, wastage of blood that is not out-of-date represents afinancial loss to the health care system. More ominously, systemic wastage of blood may reflect an environment of carethat is out of control and could pose risks to patient safety.


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30 Q-TRACKS



Monitor ObjectiveAssess patient satisfaction with outpatient phlebotomy services by measuring patients’ assessment of waiting time,discomfort level, courteous treatment, and overall satisfaction.

Data CollectionOn a monthly basis, participants will distribute copies of a questionnaire to a minimum of 25 outpatients (maximumof 99 outpatients), using predetermined data collection criteria. This monitor includes any outpatient undergoingvenipuncture or for whom assistance was required in specimen collection by your laboratory staff. This monitorexcludes patients seen in the emergency department, ambulatory surgery area, urgent care facility, chest pain center,23-hour short-stay facility, employee health department, outpatient health screening fair/promotion, dialysis center,nursing home, or extended care facility.

Performance Indicators• Patient Satisfaction Score • Patients “More Than Satisfied” (%)

Satisfaction with Outpatient Specimen Collection QT7Specimen collection is one of the few areas of laboratory medicine that involves direct outpatient contact. As a result,patient satisfaction with this service is a vital indicator of quality laboratory performance. By participating in this monitor,you can help ensure that patient satisfaction with laboratory services is being measured as required by accreditingagencies such as the Joint Commission and CAP (GEN.20316, 20348).

Stat Test Turnaround Time Outliers QT8Measuring laboratory stat test turnaround time (TAT) is useful to the laboratory in evaluating the service delivery process.The stat test TAT outlier rate, expressed as a percent of tests missing target reporting times, is a measure of outcomesthat evaluates how well the laboratory meets patient and clinician needs. This monitor helps meet CAP checklist questionGEN.20316, “Does the QM program include monitoring key indicators of quality?”

Monitor ObjectiveMonitor the frequency with which stat test TAT intervals exceed institutional stat test TAT expectations.

Data CollectionBefore beginning data collection, participants will establish a specimen receipt-to-report deadline for EmergencyDepartment (ED) stat potassium tests. On six predetermined days per month, participants will monitor the TAT of upto 10 randomly selected ED stat potassium tests on each of three eight-hour shifts (up to 180 tests per month) andtrack the number of ED stat potassium determinations reported later than the established reporting deadline. Thismonitor includes stat potassium tests ordered as part of a panel and excludes stat potassium levels that are requestedon body fluids other than blood, as part of timed or protocol studies, or after the specimen arrives in the laboratory.

Performance Indicators Performance Breakdown• Stat TAT Outlier Rate (%) • Breakdown of Outliers by Shift (%)

• Breakdown of Outliers by Day of Week (%)


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Monitor ObjectiveEstablish the compliance rate at which laboratories meet morning test reporting deadlines.

Data CollectionParticipants will choose one or more nonintensive patient care areas and/or laboratory sections to monitor. Theywill select one morning reporting deadline in conjunction with health care staff who use the laboratory. On sixpredetermined days per month, participants will record the total number of tests monitored and the total numberof specific tests reported by the designated deadline. Tests originating from intensive care units and the emergencydepartment, as well as stat requests, are excluded from this monitor.

Performance Indicator• Reporting Compliance Rate (%)

Inpatient Test Availability QT9When laboratory results are not available for a physician’s morning rounds, there may be a delay in the treatment,diagnosis, and discharge of a patient. In turn, this delay may prolong a patient’s hospital stay and cause physicians torepeat patient visits. By monitoring the frequency of test reporting times that exceed expectations, you can determineareas that require improvement, implement changes, and increase physician and patient satisfaction. Monitor thispost-analytic performance indicator to measure and address your long-term performance.

Monitor ObjectiveEvaluate the documentation of successful critical values reporting in the general laboratory for both inpatients andoutpatients according to the laboratory’s policy.

Data CollectionOn a monthly basis, participants will evaluate 120 inpatient and 120 outpatient critical values for the designatedsections. Data collection will include general chemistry, hematology, and coagulation analytes on the critical valueslist. Retrospectively, participants will record the total number of critical values monitored and if there wasdocumentation of notification. This monitor will exclude critical values for microbiology, cardiac markers, drugs ofabuse, therapeutic drug levels, urinalysis, blood gases, point-of-care tests, tests performed at reference laboratories,and critical values on discharged patients.

Performance Indicators• Total Critical Values Reporting Rate (%)• Inpatient Critical Values Reporting Rate (%)• Outpatient Critical Values Reporting Rate (%)

Critical Values Reporting QT10Critical values in the laboratory are defined as results requiring immediate notification to the physician or caregiver fornecessary patient evaluation or treatment. While critical value notification has been a routine practice in laboratorymedicine for many years, recent regulations from agencies and accreditors such as CMS, the Joint Commission, and CAP(GEN.20365, 20316, 41320) have mandated that laboratories develop and implement an alert system for critical values.Use this monitor to document compliance with your laboratory’s alert plan.


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32 Q-TRACKS



Monitor ObjectiveMonitor the number of corrected test results within individual institutions and compare performance with that of allinstitutions and those institutions similar to yours.

Data CollectionOn a monthly basis participants will monitor the number of corrected test results and the total number of billabletests for that month. Test results for all patients in all care settings will be included, with the following exclusions:anatomic pathology tests and narrative physician-interpreted tests (i.e., bone marrow biopsies and peripheral smearreports).

Performance Indicator• Test Result Correction Rate (per 10,000 billable tests)

Monitor ObjectiveDetermine the median order-to-report turnaround time (TAT) of troponin (I or T) and the percent of troponinresults reported by each institution’s established deadline.

Data CollectionParticipants will record the TATs (in minutes) for three randomly selected troponin specimens obtained from patientsseen in EDs on each of three traditional shifts (total of nine measurements) on six pre-determined days per month.TATs will be measured from the times the tests are ordered to the times that results are made available to EDpersonnel. Participants will also have the option of monitoring collection-to-receipt intervals.

Performance Indicators• Median Troponin Order-to-Report TAT (minutes)• Troponin TAT Compliance Rate (%)

Corrected Results QT16This Q-TRACKS monitor was developed in recognition of the importance of timely detection and correction of erroneouslaboratory results. Accuracy in laboratory results is critical to the effectiveness of a physician’s plan of care for a patient.An erroneous result can delay or alter patient treatment, therefore detection of erroneous results should be a priority inevery laboratory and should be monitored as a key quality indicator. Help measure your compliance with CLIA 493.1299,Postanalytic Systems Quality Assessment, with this monitor.

The swiftness with which physicians establish diagnoses of acute myocardial infarction (AMI) in patients presenting to theemergency department (ED) with chest pain may determine the type and predict the outcomes of therapy those patientswill receive. Included in the total time consumed in establishing diagnoses of AMI are the component intervals requiredto measure biochemical markers of myocardial injury, one of the most critical of which is troponin. Help meet CAPchecklist question GEN.20364 with this monitor.

Turnaround Time of Troponin QT15


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Monitor ObjectiveMeasure the incidence of incorrectly interpreted and entered outpatient physician test orders into the laboratorycomputer, compare performance across institutions, and track performance over time.

Data CollectionOn six pre-selected weekdays per month, eight outpatient requisitions or order sheets will be compared to the ordersentered into the laboratory’s information system to determine if any order entry errors occurred. Order entry errorcategories include requesting physician error, incorrect, missing, and extra test errors, test priority errors, andnon-routine routing request errors. Tests performed in transfusion medicine/blood bank or anatomic pathology areexcluded.

Performance Indicators Performance Breakdown• Outpatient Order Entry Error Rate (%) • Breakdown of Error Types (%)• Order Entry Error Rates by Type (%)

Order accuracy bears an obvious relationship to the quality of laboratory testing. When the laboratory fails to complete arequested test, the diagnostic evaluation is delayed, potentially extending a patient’s hospital stay and prolonging therapy.When the laboratory completes a test that was not requested, the cost of care increases, patients may be subjected tounnecessary phlebotomy, and laboratory efficiency declines.

Outpatient Order Entry Errors QT17

Monitor ObjectiveQuantify the correlation between the findings of cervicovaginal cytology and corresponding histologic material.

Data CollectionOn a monthly basis, participants are asked to record information on true-positive, false-positive, and false-negativecytology-biopsy correlations. False-negative correlations will be separated into four error categories. Participants willrecord the biopsy diagnoses for Pap tests with an interpretation of atypical squamous cells (ASC-US and ASC-H) oratypical glandular cells (AGC). This monitor includes patients for whom a cervical biopsy specimen is submitted tothe laboratory and for whom a satisfactory or satisfactory but limited Pap test has been submitted within threemonths previous to the biopsy or at the time of the biopsy.

Performance Indicators• Predictive Value of Positive Cytology (%) • Sensitivity (%)• Screening/Interpretation Sensitivity (%) • Sampling Sensitivity (%)• Percent Positive for ASC-US Interpretations • Percent Positive for AGC Interpretations• Percent Positive for ASC-H Interpretations

The correlation of cervicovaginal cytology (Pap test) findings with cervical biopsy results has been a staple in thecytopathology laboratory’s quality assurance program. By monitoring this correlation, the laboratory can identify potentialproblems requiring improvement, thereby ensuring better patient results.

Gynecologic Cytology Outcomes: Biopsy Correlation Performance QT5

Q-TRACKS Anatomic Pathology Monitor


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34 Q-PROBES



Evaluate quality improvements in your lab – With today’s focus on reducing medical errors,achieving and maintaining excellence is key to success. Using short-term studies, Q-PROBES provides a one-timecomprehensive assessment of key processes in your laboratory.

Structure your data collection and analysis for success – Use Q-PROBES to help buildand improve data collection and analysis processes that contribute to quality of care, patient safety, and outcomes.

Establish realistic laboratory benchmarks and performance goals – Q-PROBESis an external peer-comparison program that addresses process-, outcome-, and structure-oriented qualityassurance issues. Establish benchmarks through external database comparisons and compare your performanceto that of peer organizations to establish laboratory goals and improve performance.

A Program for an In-depth Comprehensive Assessment

Q-PROBES

Examine the effectiveness of key processes with Q-PROBES.Examine the effectiveness of key processes with Q-PROBES.

Q-PROBES offers CME/CE credit to all laboratory staff to help you build a solidfoundation of education and knowledge within your organization.

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Study ObjectiveDetermine the rate of STAT testing, expressed as the percentage of chemistry, hematology, and coagulation testing,and compare rates among institutions.

Data CollectionParticipants will prospectively determine the number of tests performed STAT and the total number of tests per-formed in the disciplines of chemistry, hematology, and coagulation from inpatients and Emergency Department (ED)patients over the course of seven days, by providing billable test counts as defined by each laboratory. Participantswill record the number of test priorities defined (eg routine, STAT, ASAP, etc.) and the expected TAT for each testpriority, expressed as (1) the time between laboratory specimen receipt and time of result verification, (2) the timebetween test order and result verification, and (3) the time between test specimen collection and result verification.(If laboratories do not publish expected TATs for all three of these intervals, “no formal expectation” for that timeinterval would be reported.) The number of orderable tests and the test name for each test offered on a STAT basiswill also be reported.

Performance Indicators• Rate of STAT testing• Percent of orderable tests offered on a STAT basis

*Shipping Begins December 8, 2008 Order Deadline February 5, 2009

Gain control over your most valuable resources by understanding the variables affecting your laboratory’s STAT testing.Of the two turnaround time (TAT) priority levels that the laboratory generally offers, STAT testing usually requires greaterresource expenditure per test result than routine testing. An excessive proportion of STAT testing may overly stresslaboratory resources. Underutilization of STAT testing may hinder safe and efficient patient management. This Q-PROBESstudy is designed to establish prevailing rates of STAT testing and to see what practice and demographic variables mayinfluence those rates.

*Orders must be received by the order deadline.

Utilization of STAT Test Priority QP091New

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36 Q-PROBES



Study ObjectiveDetermine the percentages of outpatient test orders that need clarification, are delayed, or are abandoned becauseclarifying information cannot be obtained.

Compare these percentages among institutions based on different communication media (written vs. electronic)through which orders are received, whether the orders are for locally performed or sent out tests, and whichnecessary order elements tend to be missing.

Data CollectionProspectively review outpatient test orders for three weeks or until 30 orders are found that need clarification,keeping track of the total number of order events in that period. For each test order requiring clarification, recordwhether the time needed to clarify the order was less than or greater than 30 minutes, whether the order waseventually filled or abandoned, as well as the following: electronic versus paper test order format, for whichlaboratory section the test order was intended, and whether the test would be performed locally or sent-out.

Performance Indicators• Percent of outpatient orders that require clarification• Percent of outpatient orders delayed due to need for clarification

*Shipping Begins March 23, 2009 Order Deadline April 16, 2009

Monitoring of Outpatient Orders Requiring Clarification QP092To improve patient safety, reduce laboratory waste, and increase customer satisfaction, study your institution’s outpatientorders that require clarification. Many test orders do not contain the four elements required to complete a laboratoryorder: 1) adequate patient identification, 2) a recognized ordering provider, 3) an appropriate clinical diagnosis, and 4)sufficient test information. Many outpatient orders do not contain these required elements, are illegible or garbled, arenon-specific, do not match the laboratory test menu, or are otherwise unclear. These orders must be clarified beforetesting is performed. This process always requires re-work, often causes delay, and sometimes leads to orders beingabandoned. This Q-PROBES study is designed to identify your laboratory’s clarification needs to determine processimprovement steps.


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Study ObjectiveDetermine the rates of mislabeled specimens, blocks, and slides and compare performance to other institutions.

Data CollectionProspectively track each time a specimen container, slide or block is relabeled or renumbered due to anidentification error, and indicate whether a corrected report was issued or the problem was discovered beforerelease of results. Data will be collected for eight weeks or until 30 cases are collected with at least one error.Participants will also report the number of cases, blocks, and slides (including special stains) that are processedduring the same time period.

This Q-PROBES study will be limited to routine histology processing.

Performance Indicators• Percent of mislabeled specimens• Percent of mislabeled blocks• Percent of mislabeled slides

*Shipping Begins September 21, 2009 Order Deadline October 15, 2009

Study ObjectiveDetermine institution adherence to externally mandated requirements (eg, CAP, AABB) and internally mandatedrequirements for transfusion practices and compare performance to other institutions.

Data CollectionFor 20 transfusions spaced over ten weeks, participants will review transfusion documentation one day after thetransfusion to determine the institution’s adherence to externally and internally mandated requirements.Documentation will include a transfusion order, name of each component transfused, the donor unit or pool identifi-cation number for each unit, the date and time of transfusion of each unit, pre- and post-transfusion vital signs foreach unit, the volume of each component transfused, name of all transfusing personnel, documentation of transfu-sion-related adverse events, and any additional locally required documentation. Only non-emergent transfusions areincluded in the study. Transfusions performed in the emergency department and operating rooms are excluded.

Performance Indicators• Percent of transfusions adhering to external documentation requirements (%)• Percent of transfusions adhering to additional internal documentation requirements (%), if applicable

*Shipping Begins June 22, 2009 Order Deadline July 16, 2009

Ensure patient safety by measuring your compliance with CAP, AABB, and other requirements for transfusiondocumentation.

Mislabeling Rate of Specimens, Blocks, and Slides inSurgical Pathology QP094

Mislabeling of surgical pathology specimens has high risk and high impact with respect to patient safety. This Q-PROBESstudy is designed to increase your understanding and track the variables that can lead to incorrect diagnosis andunnecessary life-altering therapy.

Quality of Transfusion Documentation QP093


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38 LMIP



Manage your laboratory more effectively with LMIP – The Laboratory ManagementIndex Program (LMIP) is an effective fiscal management tool that provides you with a valuable peercomparison of your laboratory’s performance. LMIP can assist you with the annual budget process, contractnegotiations, and daily operations management while you earn valuable CME and CE credit.

With over 10 years of experience and the largest laboratory participant database, LMIP is the best managementresource for health care professionals charged with decision-making responsibilities. Using management ratiosas performance indicators, LMIP extends beyond traditional analysis of productivity and staffing to focus on themost important factors affecting laboratory performance:

! Productivity – How effectively are you using your laboratory personnel?

! Utilization – How do your test-ordering patterns compare to those of your peers?

! Cost-effectiveness – How efficiently are you using your supplies, equipment, and labor?

With LMIP’s statistically valid method of peer grouping (fingerprint clustering), you receive the mostmeaningful comparisons. These comparisons allow you, your colleagues, and your administration to makeinformed and realistic decisions about staffing, budgets, and other performance targets.

Achieving quality test results involves more than just ensuring that tests are conducted properly. Understandingfinancial factors that drive laboratory processes enhances your confidence in the management decisions youmake. Ultimately, these decisions will guide your organization to deliver superior patient care.

Laboratory Management Index Program

LMIP

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LMIPLMIP input items are collected and analyzed quarterly to provide a report of your laboratory’s overall operations. Thedata collected is used to generate relevant management ratios that provide analysis of the productivity of personnel,laboratory policies and procedures, salary and other expenses, physician test utilization, and organizational benefits.The input items you will collect include:

! Blood Expense

! Consumable Expense

! Equipment Depreciation Expense

! Equipment Maintenance and Repair Expense

! Hospital Inpatient Days

! Hospital Inpatient Discharges

! Inpatient SBTs

! Nonpatient SBTs

! On-Site SBTs

! Outpatient SBTs

! Outpatient Visits

! Referred SBTs

! Referred SBT Expense

! Testing Labor Expense

! Testing Paid Hours

! Total Labor Expense

! Total Laboratory Paid Hours

! Total Laboratory Worked Hours

! Total SBTs

The Standardized Billable Test (SBT) is the primary unit of measure for LMIP. The SBT is a method of standardizing testcounts and eliminates billing, accounting, and interpretation variations to ensure valid comparisons are created.

Upon completing the program and education activity, you will have learned how to:" Consistently and accurately calculate Standardized Billable Tests

" Categorize and calculate laboratory expenses to be used in establishing laboratory specific LMIP performanceratios

" Apply LMIP definitions for consistent reporting between institutions and articulate the procedure for interpretingor evaluating laboratory performance

" Categorize and calculate laboratory staffing levels and types as they relate to the LMIP program

LMIP offers CME/CE credit to one individual each quarter to help you builda solid foundation of education and knowledge within your organization.

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40 CAP LINKS



The Integrated Knowledge Source

CAP LINKS

Consolidate proficiency testing, accreditation, and QI data for your entireorganization into concise and actionable reports.

CAP LINKS is designed for multihospital systems, academic medical centers with numerous testing locations,and national commercial reference laboratories. CAP LINKS provides a high level overview useful in identifyingimprovement opportunities and demonstrating good QI performance. CAP LINKS data are accessed directlyfrom the CAP Laboratory Improvement Database. Therefore, no additional data submission is required.CAP LINKS is available for all of your CAP laboratory improvement programs, including:

! Surveys & Anatomic Pathology Education Programs and EXCEL®

! Laboratory Accreditation Program

! Q-TRACKS Program

! LMIP - Laboratory Management Index Program

CAP LINKS has been enhanced to provide you the ability to:

! Download data and manipulate reports to accommodate your specificinstitution’s needs

! Use e-mail to forward one or all reports to appropriate individuals for viewing

! Designate viewing options to select individuals via the CAP Web site directly

! Receive CAP LINKS reports more promptly via the Web—your printed reports willcontinue to be forwarded via regular mail

! Respond to exceptions in a more timely manner

The report package allows you to quickly see good performance and identify sites that may require specialattention, both at the laboratory level and at the system or corporate level.

Reports are generated on a quarterly basis and distributed by mail and via the Internet to an individual whomyou designate as your system’s primary contact. Annually, your primary contact will receive an overview ofthe system’s full-year performance for proficiency testing. Online reports are secure and viewable by thoseindividuals with granted viewing privileges.

AccessCAP LINKS

ReportsOnline

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Accreditation reports recap inspection findings for each laboratory.

Quarterly reports summarize PT system-wide average results by discipline toallow for interlaboratory comparisons.

Inspection Performance Overview by LaboratoryLaboratory Accreditation Program

Northwest Hospital System

Note: Includes inspection deficiency information used in the most recent accreditation decision

College of American Pathologists325 Waukegan Road, Northfield, Illinois 60093-2750800-323-4040 ! www.cap.org

23451-01 05/25/2001 Laboratory 1

Cambridge, MA

23455-01 05/25/2001Laboratory 2

Johnston, RI

23478-01 08/16/2001 Laboratory 3 Pittsburg, PA

42 Quality Management Tools



Combination Program OptionsProduct Surveys/

LAP Q-TRACKS LMIP PriceCode EXCEL®

Option 1 IMR1 ! ! ! ! $2,800Option 2 IMR2 ! ! $2,000Option 3 IMR3 ! ! ! $2,200Option 4 IMR4 ! ! ! $1,500Individual Program OptionsSurveys/EXCEL Program IMRPT ! $1,500Laboratory Accreditation Program IMRLP ! $800Q-TRACKS IMRQT ! $500LMIP IMRLM ! $500

QUALITY MANAGEMENT TOOLS PRICING OVERVIEW

Modules/Package Product Codes Price

Individual Clinical Pathology (CP) MonitorsQT1, QT2, QT3, QT4, QT7, QT8, $940 eachQT9, QT10, QT15, QT16, QT17

Individual Anatomic Pathology (AP) Monitor QT5 $940 eachCombined CP/AP Module–

Includes all 12 QT Monitors QTP $9,700Clinical Pathology Module–

Includes all 11 CP Monitors QTC $9,380Patient Safety Module

Includes QT1, QT2, QT10, QT15, QT16, QT17 QTS $4,988

2009 Q-TRACKS

Modules/Package Product Codes PriceIndividual QP Studies QP091, QP092, QP093, QP094 $395 eachAll Four QP Studies PRO $1,424

Module Product Code Price

LMIP LMB $820

2009 Q-PROBES

2009 LMIP

2009 CAP LINKS

5POINT OF CARE TESTING

This chapter provides a single-source referencefor all point of care testing.

Poin

tofC

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Point of Care ProgramsIn many hospitals today, laboratory testing has shifted from the central main laboratory to inpatient rooms, emergencydepartments, and intensive care units. With this shift and the increased use of point of care instruments within thehospital setting, we have developed this chapter to focus on point of care testing. This chapter is specificallydesigned to assist you in selecting the most appropriate proficiency testing products for individuals performing nearpatient and bedside testing in the hospital setting. For additional information about selecting the right products foryour institution, contact the CAP at 800-323-4040 option 1.

Please reference the following charts for the most appropriate proficiency testing module to meet your testing needs.

Page Number(s)Critical Care Aqueous Blood Gas (AQ, AQ2) 73Blood Oximetry (SO) 74

Blood Gas, Critical Care and Oximetry

Page Number(s)B-type Natiuretic Peptides (BNP) 55Glycohemoglobin (GH2) 60Limited Chemistry, Waived (LCW) 52Neonatal Bilirubin (NB, NB2) 63Plasma Cardiac Markers (PCARM) 53Whole Blood Glucose (WBG, WB2) 65

Chemistry

Page Number(s)Activated Clotting Time (CT, CT1, CT2, CT3) 128Platelet Function (PF1) 127Thromboelastogram (TEG) 127Whole Blood D-dimer (WBDD) 127Whole Blood Prothrombin Time/INR (WP3, WP4, WP6, WP7, WP8, WP9) 126

Coagulation

44 Point of Care Programs



Page Number(s)Amniotic Fluid Leakage (Nitrazine Test) (AFL) 113Blood Cell Counts (HE, HEK, HEP, FH Series) 107, 108Erythrocyte Sedimentation Rate (ESR, ESR1) 111Gastric Occult Blood (GOCB) 119Occult Blood (OCB) 118Reticulocytes (RT, RT2, RT3, RT4) 110Rupture of Fetal Membranes (ROM) 113Urinalysis/Urine hCG, qualitative/Clinical Microscopy (CM, CMP, CMM, CMMP) 115, 117Waived Combination (HCC) 112

Hematology and Clinical Microscopy

Page Number(s)Rapid A Strep Antigen Detection (D6 and D9) 132, 134

Microbiology

Page Number(s)Urine Drug Screen, Limited (UDS6) 79

Toxicology

Page Number(s)Anti-HIV-1, waived (RHIVW) 174Anti-HIV-1/2, waived (AHIVW) 174Infectious mononucleosis (IMW) 151

Immunology

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The following listing has been created to assist you in selecting the most appropriate CAP Survey products to meet yourtesting needs. It is not intended to be construed as approval or disapproval of any product or instrument. Please contact aCAP Customer Contact Representative at 800-323-4040 option 1 or your instrument manufacturer for other compatibilityquestions. Select the compatible Survey for your instrument and cartridge from the charts.

Recommended CAP Surveyi-STAT Cartridge Survey Code Survey Name Page Number(s)

G3+ AQ 73CG4+ AQ 73EG6+ AQ 73EG7+ AQ 73CG8+ AQ2 73G AQ2 73Crea AQ2 73E3+ AQ2 73EC4+ AQ2 736+ AQ2 73EC8+ AQ2 73CHEM8+ AQ2 73CeliteACT CT1 Activated Clotting Time 128KaolinACT CT1 Activated Clotting Time 128PT/INR WP3 Whole Blood Coagulation 126

Cardiac Markers CKMB PCARM Plasma Cardiac Markers 53BNP PCARM Plasma Cardiac Markers 53cTnl PCARM Plasma Cardiac Markers 53

Abbott Point of Care – i-STAT®

Critical Care Aqueous Blood Gas

Critical Care Aqueous Blood Gas

Blood Gas+

Chemistry+

Coagulation

Recommended CAP SurveyBiosite Instrument Survey Name Survey Code Page Number(s)Triage® Cardiac Panel Plasma Cardiac Markers PCARM 53Triage® BNP B-type Natriuretic Peptides BNP 55Triage® CardioProfilER Plasma Cardiac Markers PCARM, BNP 53, 55Triage® Profiler Plasma Cardiac Markers, BNP PCARM, BNPShortness of Breath 53, 55Triage® Tox Drug Screen Urine Drug Screen UDS, UDS6 79Triage® Drugs of Abuse Panel Urine Drug Screen UDS, UDS6 79

Biosite®, Inc.

6GENERAL CHEMISTRY AND

THERAPEUTIC DRUG MONITORING

New for 2009! Lipoprotein-Associated Phospholipase (Lp-PLA2) (PLA)

! Neonatal Bilirubin Survey, 2 challenges (NB2)

! Urine Bence Jones Proteins (UBJP)

Gene

ral

Chem

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erap

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onito

ring

General Chemistry and Therapeutic Drug Monitoring ..............47

General Chemistry–Related Surveys ......................................51

Urine Chemistry ..................................................................58

Special Chemistry ................................................................60

Subdisc ip l ines

General Chemistry and Therapeutic Drug Monitoring 47


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General Chemistry and Therapeutic Drug MonitoringAnalytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS).

ChallengesAnalytes C1 C3 CZ CZ2 Z per ShipmentAlanine aminotransferase (ALT/SGPT) ! ! ! ! 5Albumin ! ! ! ! 5Alkaline phosphatase ! ! ! ! 5Amylase ! ! ! ! 5Aspartate aminotransferase (AST/SGOT) ! ! ! ! 5Bilirubin, direct ! ! ! ! 5Bilirubin, total ! ! ! ! 5Calcium ! ! ! ! 5Chloride ! ! ! ! 5Cholesterol ! ! ! ! 5Cortisol ! ! ! ! 5Creatine kinase (CK) ! ! ! ! 5Creatinine ! ! ! ! 5Glucose ! ! ! ! 5HDL cholesterol ! ! ! ! 5Human chorionic gonadotropin

(hCG, quantitative) ! ! ! ! 5Iron ! ! ! ! 5Lactate dehydrogenase (LD) ! ! ! ! 5LDL cholesterol ! ! ! ! 5Lipoprotein (a) ! ! ! ! 5Magnesium ! ! ! ! 5Potassium ! ! ! ! 5Protein, total ! ! ! ! 5Sodium ! ! ! ! 5T3 free ! ! ! ! 5T3, total ! ! ! ! 5T3 uptake ! ! ! ! 5T4, free (Thyroxine, free) ! ! ! ! 5T4, total (Thyroxine, total) ! ! ! ! 5Thyroid-stimulating hormone (TSH) ! ! ! ! 5Triglycerides ! ! ! ! 5Urea (BUN) ! ! ! ! 5Uric Acid ! ! ! ! 5


General Chemistry and Therapeutic Drugs(C1, C3, C3X, CZ, CZX, CZ2, CZ2X, Z)

48 General Chemistry and Therapeutic Drug Monitoring



General Chemistry and Therapeutic Drugs, continuedChallenges

Analytes C1 C3 CZ CZ2 Z per ShipmentAcid phosphatase ! ! ! 2Ammonia ! ! ! 2Apolipoprotein A1 ! ! ! 2Apolipoprotein B ! ! ! 2Calcium, ionized ! ! ! 2Carbon dioxide ! ! ! 2Ferritin ! ! ! 2Gamma glutamyl transferase (GGT) ! ! ! 2Lactate ! ! ! 2Lipase ! ! ! 2Osmolality ! ! ! 2Pancreatic amylase ! ! ! 2Phosphorus (inorganic) ! ! ! 2Prealbumin ! ! ! 2Total iron binding capacity (measured) and % saturation ! ! ! 5Transferrin ! ! ! 5Unsaturated iron binding capacity,(measured) ! ! ! 5Lithium ! ! ! ! ! 5Acetaminophen ! ! ! 2Carbamazepine ! ! ! 5Digoxin ! ! ! 5Ethosuximide ! ! ! 5Gentamicin ! ! ! 5N-acetylprocainamide (NAPA) ! ! ! 5Phenobarbital ! ! ! 5Phenytoin ! ! ! 5Primidone ! ! ! 5Procainamide ! ! ! 5Quinidine ! ! ! 5Salicylate ! ! ! 2Theophylline ! ! ! 5Tobramycin ! ! ! 5Valproic acid ! ! ! 5Vancomycin ! ! ! 5Amikacin ! ! ! 2Caffeine ! ! ! 2Carbamazepine, free ! ! ! 2


General Chemistry and Therapeutic Drug Monitoring 49


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Product InformationEach C1, C3, CZ, and Z shipment will contain five 5.0-mL liquid serum specimens. See above for additional volumeoptions. Customers may elect to report in conventional or International System of Units (SI).

Each shipment of CZVM ordered will consist of five 5.0-mL serum specimens

Note: The General Chemistry and Therapeutic Drug Surveys do not fulfill the requirements for NeonatalBilirubin proficiency testing. For laboratories performing Neonatal Bilirubin analysis, please refer to the NB orNB2 Survey found on page 63.

An education activity is planned that includes reading material found in the Participant Summary and online learningassessment questions. All laboratory staff can participate individually and earn free CE credit without leaving thelaboratory.

Product Fulfillment Group C and Z

General Chemistry and Therapeutic Drugs, continued

GENERAL CHEMISTRYC3X (Comprehensive Chemistry with two sets of vials and single reporting)CZX (Comprehensive Chemistry and TDM with two sets of vials and single reporting)CZ2 (Comprehensive Chemistry and TDM with two sets of vials and double reporting)CZ2X (Comprehensive Chemistry and TDM with three sets of vials and double reporting)CHEMISTRY AND THERAPEUTIC DRUG MONITORING VALIDATED MATERIAL (CZVM)

ChallengesAnalytes C1 C3 CZ CZ2 Z per ShipmentDigoxin, free ! ! ! 2Disopyramide ! ! ! 2Flecainide ! ! ! 2Lidocaine ! ! ! 2Methotrexate ! ! ! 2Phenytoin, free ! ! ! 2Valproic acid, free ! ! ! 2

CE

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50 General Chemistry and Therapeutic Drug Monitoring



Analyte CS Challenges per ShipmentCyclosporine ! 3Sirolimus (Rapamycin) ! 3Tacrolimus ! 3

Product InformationSurvey CS is designed for laboratories monitoring cyclosporine, sirolimus, and tacrolimus in transplant patients. Eachshipment will include three 5.0-mL whole blood specimens.

Product Fulfillment Group CSM

AACC/CAP Immunosuppressive Drugs CS

Analyte ZT Challenges per ShipmentAmitriptyline ! 1Desipramine ! 1Imipramine ! 1Nortriptyline ! 1Tricyclics, total (qualitative & quantitative) ! 2

Therapeutic Drug Monitoring (TDM) (Special) ZT (ZZT)

Product InformationLaboratories enrolled in Survey ZT that require additional material should order Survey ZZT. Each shipment of SurveyZT will include two 5.0-mL lyophilized serum specimens.

Product Fulfillment Group ZT

TDM (SPECIAL)ZZT (ZT, with a duplicate set of vials)

Analyte MPA Challenges per ShipmentMycophenolic acid ! 3

Product InformationEach shipment will include three 5.0-mL lyophilized serum specimens.

Product Fulfillment Group CSM

Mycophenolic Acid MPA

General Chemistry—Related Surveys 51


www.cap.org

Analyte CFS Challenges per ShipmentAlbumin ! 1Bilirubin ! 1Chloride ! 1Cortisol ! 1Creatinine ! 1Glucose ! 1Iron ! 1Magnesium ! 1Phosphorus ! 1Potassium ! 1Protein, total ! 1Sodium ! 1Thyroxine (T4), total ! 1Urea nitrogen (BUN) ! 1Uric acid ! 1

General Chemistry–Related SurveysAnalytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS).

Commutable Frozen Serum CFS

Note: No claims can be made for the stability of the sample if thawed and refrozen.

Product InformationThis product will provide laboratories the opportunity to purchase commutable frozen serum material for use inestablishing traceability of their analytical measurement systems. Data need not be returned to the CAP.

Each shipment includes one 10.0-mL frozen neat serum sample. Laboratories will also receive a table of thereference measurement procedures and assigned values. Note: Quantities are limited. Order early toensure enrollment. Product can be ordered anytime during the year.

52 General Chemistry—Related Surveys



Analyte LCW Challenges per ShipmentAlanine aminotranferase (ALT) ! 3Aspartate aminotransferase (AST) ! 3Cholesterol ! 3Glucose ! 3HDL cholesterol ! 3LDL cholesterol ! 3Triglycerides ! 3

Limited Chemistry, Waived LCW

Product InformationLCW is designed specifically for users of the Cholestech L•D•X and other waived cholesterol methods. Theglucose specimens are not compatible with other whole blood glucose meters. AST testing is available for theCholestech L•D•X.

Analyte ABL Challenges per ShipmentApolipoprotein A1 ! 3Apolipoprotein B ! 3Cholesterol* ! 3HDL cholesterol* ! 3LDL cholesterol* ! 3Lipoprotein (a) NEW ! 3Triglycerides* ! 3

Accuracy Based Lipid Survey ABL

Product InformationEach shipment of Survey ABL will contain three 2.0-mL serum specimens for quantitative determination ofapolipoproteins A1 and B, cholesterol, HDL and LDL cholesterol, Lp(a), and triglycerides.

*Accuracy based grading will use the target values that are based upon the Centers for Disease Control andPrevention (CDC) reference method by the Lipid Reference Laboratory, Clinical Chemistry Branch, CDC, Atlanta,Georgia.



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Analyte PCARM Challenges per ShipmentCK-MB ! 5Myoglobin ! 2Troponin I ! 2BNP ! 2

Plasma Cardiac Markers PCARM

Product InformationSurvey PCARM is designed for use with the BioSite Triage®, i-STAT®, and Response Biomedical RAMP® CardiacMarkers System only.

Each shipment of PCARM includes five 1.0-mL liquid EDTA plasma specimens.

Analyte PLA Challenges per ShipmentLipoprotein-associated phospholipase (Lp–PLA2) ! 2

Lipoprotein-Associated Phospholipase PLA

Product InformationEach shipment of PLA will include two liquid specimens for the quantitation of Lp–PLA2.




Analyte CARM TRP CRT CARMI CRTI Challenges per ShipmentCreatine Kinase (CK) ! ! ! ! 5CK-MB, immunochemical ! ! ! ! 5CK isoenzymes (CK-BB, CK-MB, CK-MM),electrophoretic ! ! 5

Lactate Dehydrogenase (LD) ! ! ! ! 5LD1, LD2, LD3, LD4, LD5, electrophoretic ! ! 5LD1/LD2 ratio, calculation and interpretation ! ! 5Myoglobin ! ! ! 2Troponin I ! ! ! 2Troponin T ! ! ! 2

Cardiac Markers CARM, TRP, CRT, CARMI, CRTI

Product InformationSurveys CARM and CRT are designed for laboratories performing cardiac marker testing using immunochemicalmethods. Survey TRP allows for qualitative and quantitative reporting and is designed for laboratories performingcardiac marker testing for Troponin I and Troponin T. Specimens must be tested immediately upon receipt.

Surveys CARMI and CRTI are designed for laboratories performing cardiac marker testing using electrophoreticmethods.

Each shipment of Surveys CARM, CRT, CARMI, and CRTI will include five 2.0-mL serum specimens. Survey CRTI willinclude two additional 2.0-mL serum specimens for myoglobin and troponin testing. Survey TRP will include two2.0-mL serum specimens.

Product Fulfillment Group CAR (CARM, CRT, TRP)

Product Fulfillment Group CARI (CARMI, CRTI)



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Analyte BNP Challenges per ShipmentBNP ! 2NT-pro BNP ! 2

Product InformationSurvey BNP will include two 1.0-mL liquid plasma specimens.

B-type Natriuretic Peptides Survey BNP

Analyte HCC Challenges per ShipmentHemoglobin ! 2Glucose ! 2

Product InformationSurvey HCC is designed for participants using the HemoCue® and the Stanbio HemoPoint® H2 instruments. Eachmailing will include two 1.0-mL whole blood specimens.

Waived Combination HCC

Analyte ADL Challenges per ShipmentAldolase ! 2

Product InformationEach shipment of ADL will include two 1.5-mL liquid specimens for quantitative determination of aldolase.

Aldolase ADL




Analyte V Challenges per ShipmentViscosity ! 2

Product InformationEach shipment will include two 10.0-mL serum specimens.

Viscosity V

Analyte/Procedure LPE SPE UBJP Challenges per ShipmentLipoprotein electrophoresis ! 2IgA, quantitation ! 2IgG, quantitation ! 2IgM, quantitation ! 2M-Protein (Paraprotein) identification ! 2Protein, total ! 2Protein electrophoresis ! 2Protein electrophoresis pattern interpretation ! 2Urine Bence Jones Proteins ! 2

Product InformationEach shipment of Surveys LPE and SPE will contain two 1.0-mL lyophilized specimens. Each shipment of Survey UBJPwill contain two 10.0-mL urine specimens.

Product Fulfillment Group ELP

Lipoprotein and Protein Electrophoresis LPE, SPE, UBJP

Analyte C7 Challenges per ShipmentPseudocholinesterase ! 1

Product InformationEach shipment will include one 2.0-mL lyophilized serum specimen.

Product Fulfillment Group C

Pseudocholinesterase C7



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Analyte KET Challenges per ShipmentBeta-hydroxybutyrate ! 2Total ketones ! 2

Analyte hsCRP Challenges per ShipmentHigh-sensitivity C-reactive protein ! 3

Product InformationEach shipment will include two 2.0-mL serum specimens. Survey KET is designed for the measurement of ketonesusing Acetest or other qualitative or semi-quantitative methods using the nitroprusside reaction. This Survey is alsodesigned for quantitative analysis of beta-hydroxybutyrate to assess diabetic ketoacidosis or to monitor patients onketogenic diets.

Ketones KET

Analyte HMS Challenges per ShipmentHomocysteine** ! 3

Product InformationEach shipment will include three 1.0-mL serum specimens.

Product Fulfillment Group CR

Homocysteine HMS

Product InformationEach shipment will include three 0.5-mL liquid serum specimens for high-sensitivity or cardiac C-reactive proteinanalysis. For laboratories performing routine C-reactive protein analysis, please refer to the CRP Survey inChapter 15.


High-Sensitivity C-reactive Protein hsCRP

** “Confirmatory results,” based upon the reference method performed by the Clinical Chemistry Branch, Centersfor Disease Control and Prevention, Atlanta, Georgia, are provided.

58 Urine Chemistry



Urine Chemistry

Analyte U Challenges per ShipmentAmylase ! 3Calcium ! 3Chloride ! 3Creatinine ! 3Glucose ! 3Magnesium ! 3Nitrogen, total ! 3Osmolality ! 3Phosphorus ! 3Potassium ! 3Protein, total ! 3Sodium ! 3Urea ! 3Uric acid ! 3Urine albumin (quantitative) ! 3Urine albumin/creatinine ratio ! 3

Product InformationEach shipment will include six 15.0-mL urine specimens.

Each set of UVM ordered will consist of six 15.0-mL urine specimens.

Analytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS).

Urine Chemistry (General) U

URINE CHEMISTRY (GENERAL)VALIDATED MATERIAL (UVM)

Urine Chemistry 59


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Analyte N Challenges per Shipment3-Methoxytyramines ! 35-Hydroxyindoleacetic acid ! 317-Hydroxycorticosteroids ! 317-Ketosteroids ! 3Aldosterone ! 3Coproporphyrins ! 3Cortisol, urinary free ! 3Dopamine ! 3Epinephrine ! 3Homovanillic acid ! 3Metanephrine ! 3Norepinephrine ! 3Normetanephrine ! 3Uroporphyrin ! 3Vanillylmandelic acid ! 3

Urine Chemistry (Special) N

URINE CHEMISTRY (SPECIAL)VALIDATED MATERIAL (NVM)

Analyte MYG Challenges per ShipmentMyoglobin, urine ! 2

Product InformationEach shipment includes two 1.0-mL urine samples for the qualitative and quantitative determination of myoglobin.

Myoglobin, Urine MYG

Note: Albumin, beta-2-microglobulin, catecholamines (free), oxalate, and porphobilinogen will no longer beavailable in the N Survey.

Product InformationEach shipment of Survey N and NVM will include six 10.0-mL vials of lyophilized urine specimens.

60 Special Chemistry



Analyte GH2 Challenges per ShipmentGlycohemoglobin (HbA1c) ! 3

Special Chemistry

Analyte CD Challenges per ShipmentBeta-2-microglobulin, urine ! 3Cadmium, urine ! 3Cadmium, whole blood ! 3Creatinine, urine ! 3

Product InformationEach shipment will include three 5.0-mL whole blood specimens and three 15.0-mL liquid urine specimens.


Product InformationEach shipment will include three 0.7-mL liquid human whole blood specimens. Survey GH2 results will be gradedagainst the reference method used in the National Glycohemoglobin Standardization Program.

Cadmium CD

Glycohemoglobin GH2

Note: Glycohemoglobin (GHb) will no longer be available in the GH2 Survey.

Special Chemistry 61


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Analyte/Procedure LM LM1 Challenges per ShipmentBilirubin (!OD450) ! 1Fluorescent polarization assay ! ! 3Lecithin:sphingomyelin (L:S) ratio ! ! 3Phosphatidylglycerol (PG) ! ! 3

Product InformationSurvey LM is compatible with the Irvine Scientific AmnioStat-FLM, Abbott FLM II, and Helena L/S ratio methodologies.Survey LM1 is designed for laboratories that also perform bilirubin testing on amniotic fluid.

Each shipment of Survey LM will include three 5.0-mL liquid simulated amniotic fluid specimens. Each shipment ofLM1 will include three 5.0-mL liquid simulated amniotic fluid specimens and one 5.0-mL liquid simulated amnioticfluid specimen for bilirubin testing.

Lung Maturity LM, LM1

Analyte FT Challenges per ShipmentFructosamine ! 2


Fructosamine FT

!

Analyte G6PDS Challenges per ShipmentG6PD ! 2

Product InformationEach shipment includes two 0.5-mL lyophilized hemolysate samples for the quantitative and qualitative determinationof glucose-6-phosphate dehydrogenase.

Glucose-6-phosphate Dehydrogenase G6PDS




Product InformationEach shipment will include three 3.0-mL liquid simulated body fluid specimens for chemistry analysis.

Analyte FLD Challenges per ShipmentAlbumin ! 3Amylase ! 3Cholesterol ! 3Creatinine ! 3Glucose ! 3Lactate ! 3Lactate dehydrogenase (LD) ! 3pH ! 3Protein, total ! 3Triglycerides ! 3

Body Fluid FLD

Analyte M Challenges per ShipmentElectrophoresis (albumin and gamma globulin) ! 3Albumin, quantitative ! 3Glucose ! 3IgG, quantitative ! 3Lactate ! 3Lactate dehydrogenase (LD) ! 3Oligoclonal bands ! 3Protein, total ! 3

Product InformationEach shipment will include three 5.0-mL liquid simulated spinal fluid specimens for chemistry analysis. Each set ofMVM ordered will include three simulated spinal fluid specimens.

CEREBROSPINAL FLUID VALIDATED MATERIAL (MVM)

Cerebrospinal Fluid Chemistry M



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Analyte R Challenges per ShipmentAluminum ! 3Chromium ! 3Copper ! 3Manganese ! 3Selenium ! 3Zinc ! 3

Product InformationSurvey R meets the proficiency testing needs of laboratories that quantify trace metals in human health and disease.Each shipment will include three 5.0-mL serum specimens.

Trace Metals R

Analyte NB NB2 Challenges per ShipmentBilirubin, direct ! ! 2Bilirubin, total ! ! 5/2

Product InformationSurveys NB and NB2 includes decision points for use in phototherapy and/or exchange transfusion and is designed torepresent clinical conditions observed in neonates.

Each shipment of Survey NB will include five 2.0-mL serum specimens.

Each shipment of Survey NB2 will include two 2.0-mL serum specimens.

One specimen in each mailing of NB and NB2 will be human-based serum. A second set of grading criteria, ie,comparison to the value assigned using the reference method procedure (Clin Chem. 1985;31:1779-1789), will beapplied to this specimen for educational purposes only.

Neonatal Bilirubin NB, NB2

Analyte ACE Challenges per ShipmentAngiotensin converting enzyme ! 2

Product InformationEach shipment includes two 2.0-mL serum samples for the quantitative determination of ACE.

Angiotensin Converting Enzyme ACE

*Note: Survey NB2 must be ordered in conjunction with a 5 challenge total bilirubin proficiency testing product inorder to meet CMS requirements.

New




Analyte SW1 SW2 SW3 SW4 Challenges per ShipmentChloride ! ! ! ! 3Conductivity ! ! ! ! 3Osmolality ! ! ! ! 3Sodium ! ! ! ! 3

Analyte SW1 SW2 SW3 SW4 Materials IncludedOrion Direct Electrode ! Precut 2-cm–diameter

Whatman filter papersWescor Macroduct & Nanoduct ! 22-gauge blunt-tipped needlesCF Indicator System ! Polystyrene boats and

chloride-free spongesAll other methodologies ! No additional materials provided

Product InformationThe Sweat Analysis Series is designed for use with specific collection devices. Appropriate supplies for each collectionmethod are provided along with the specimens. Each shipment will include three 5.0-mL aqueous specimens thathave been formulated to resemble human sweat.

Product Fulfillment Group SW

Compatibility Matrix for Sweat Analysis Series

Sweat Analysis Series SW1, SW2, SW3, SW4

Analyte FCFS Challenges per ShipmentFecal fat ! 2

Product InformationEach shipment includes two simulated fecal fat samples for qualitative testing.

Qualitative testing is intended for microscopic analysis and determination of neutral and/or split fats.

Fecal Fat FCFS



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Challenges per ShipmentAnalyte WBG WB2Glucose 5 3

Product InformationWith Surveys WBG and WB2, you can report results from 20 different ancillary testing sites or instruments. If yourinstitution performs testing for more than 20 sites or instruments, multiple kits may be purchased to meet yourindividual needs. Survey WBG shipments will include five 2.5-mL whole blood specimens. Survey WB2 shipmentswill include three 2.5-mL whole blood specimens and will be shipped twice per year.

Whole Blood Glucose WBG, WB2

Analyte CYS Challenges per ShipmentCystatin C ! 2

Product InformationEach shipment will include two 1.0-mL liquid serum specimens.

Cystatin C CYS

Analyte PHG Challenges per ShipmentPlasma hemoglobin ! 2

Product InformationEach shipment will include two 2.0-mL liquid specimens.

Plasma Hemoglobin PHG

LNLNExpress CAPHas

CreatedTools to

HelpYou

ManageYour

Workload

Alerts you that your PT products have shipped, resulting in less worries.

Designed to assist laboratories establish and/or verify reference intervals.Data collection and analysis follows recommendations specified in CLSI’sdocument, Defining, Establishing, and Verifying Reference Intervals in theClinical Laboratory; Proposed Guideline—Third Edition (C28-P3).

! Saves valuable time, getting results up to 10 days sooner! Minimizes PT failure with pre-populated electrnic forms and drop

down menus! Eliminates clerical errors due to scanning or faxing! Manages your workload with timely e-mail reminders for data

submission and result reporting

Within four days of input, you can access your time critical evaluation ofLinearity Reports, utilizing e-LAB SolutionsTM.

Designed to provide ongoing information about Proficiency Testing (PT),the Laboratory Accreditation Program (LAP), and the education divisions ofthe College of American Pathologists. The newsletter will be available forreview on the CAP Web site by selecting the Accreditation and LaboratoryImprovement tab.

A tool designed to provide regulatory and other important informationrelative to CAP products and services that contain time-sensitive implicationsfor laboratories.

SM

Reference Range Service

7ENDOCRINOLOGY

Endo

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olog

y

Endocrinology ....................................................................67

Therapeutic Drug Monitoring ..............See page 47 in Chapter 6

Subdisc ip l ines

Endocrinology 67


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Product InformationEach shipment will include two 5.0-mL lyophilized specimens for PSA, cPSA, and free PSA testing, and five 10.0-mLliquid serum specimens for all other Survey K analytes. Customers may report in conventional or International Systemof Units (SI).Each set of KVM ordered will consist of two 5.0-mL lyophilized specimens for PSA, complex PSA, and free PSA, andfive 10.0-mL liquid serum specimens for all other Survey K analytes.

Product Fulfillment Group K

Analyte K Challenges per ShipmentAlpha-fetoprotein (AFP) ! 5CEA ! 3Cortisol ! 5Ferritin ! 3Folate, serum ! 3hCG, quantitative ! 5IgE ! 5Prostate-specific antigen (PSA) ! 2Prostate-specific antigen, complex (cPSA) ! 2Prostate-specific antigen, free (PSA) ! 2PSA ratio ! 1Prostatic acid phosphatase (PAP) ! 3T3, free ! 3T3, total (Triiodothyronine) ! 5T3 uptake and related tests ! 5T4, free (Thyroxine) ! 5T4, total (Thyroxine) ! 5Thyroid-stimulating hormone (TSH) ! 5Vitamin B12 ! 3

Ligand Assay (General) K (KK)


Endocrinology

LIGAND ASSAY (GENERAL)KK (K, with a duplicate set of vials)LIGAND ASSAY (GENERAL) VALIDATED MATERIAL (KVM)

68 Endocrinology



Analyte TM TMX Challenges per ShipmentAdrenocorticotropic hormone (ACTH) ! ! 3Beta-2-microglobulin ! ! 3CA 15-3 ! ! 3CA 19-9 ! ! 3CA 27.29 ! ! 3CA 72-4 ! ! 3CA 125 ! ! 3Calcitonin ! ! 3Interleukin-2 receptor (Soluble IL-2) ! ! 3Thyroglobulin ! ! 3

Tumor Markers TM, TMX

Product InformationSurvey TM will include three 3.0-mL liquid serum specimens. Survey TMX will consist of two duplicate sets.

Product Fulfillment Group TM

Analyte FOL Challenges per ShipmentRBC folate ! 2

Product InformationEach shipment will include two 2.0-mL whole blood specimens.

Product Fulfillment Group K

RBC Folate FOL

Analyte BNP Challenges per ShipmentBNP ! 2NT-pro BNP ! 2

Product InformationSurvey BNP will include two 1.0-mL liquid plasma specimens.

B-type Natriuretic Peptides Survey BNP

Endocrinology 69


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Analyte Y DY Challenges per Shipment11-Deoxycortisol ! 317-Hydroxyprogesterone ! 3Androstenedione ! 3DHEA sulfate ! 3Estradiol ! 3Estriol, unconjugated (uE3) ! 3Follicle-stimulating hormone (FSH) ! 3Growth hormone ! 3IGF-1 (Somatomedin C) ! 3Luteinizing hormone (LH) ! 3Progesterone ! 3Prolactin ! 3Testosterone ! 3Testosterone, bioavailable ! 3Testosterone, free ! 3Sex hormone-binding globulin (SHBG) ! 3

Product InformationSurvey DY allows participants to report testosterone (free), testosterone (bioavailable), and sex hormone-bindingglobulin with Survey Y or YY. Survey DY must be purchased in conjunction with Survey Y or YY. Each shipment ofSurvey Y will include six 5.0-mL liquid serum specimens, consisting of two duplicate sets. Each shipment of SurveyYY will include nine 5.0-mL liquid serum specimens, consisting of three duplicate sets.

Each set of YVM ordered will consist of six 5.0-mL liquid serum specimens, consisting of two duplicate sets.

Product Fulfillment Group Y

Ligand Assay (Special) Y (YY), DY

Module DY (data processing for testosterone [free and bioavailable] and sex hormone-binding globulin[SHBG] reporting)YY (additional vials of Survey Y)

LIGAND ASSAY (SPECIAL) VALIDATED MATERIAL (YVM)

70 Endocrinology



Analyte BU Challenges per ShipmentC-Telopeptide (CTX) ! 2Creatinine ! 2Deoxypyridinoline (DPD) ! 2N-Telopeptide (NTX) ! 2Pyridinoline (PYD) ! 2

Bone and Mineral Metabolism, Urine BU

Product InformationEach shipment will include two 2.0-mL lyophilized human urine specimens.


Analyte BGS Challenges per Shipment25-OH Vitamin D ! 2IGF-1 ! 2Osteocalcin ! 2

Product InformationEach shipment will contain two 5.0-mL vials of liquid serum.


Bone and Growth BGS

Analyte/Procedure PGx Challenges per ShipmentAllele detection ! 2

Product InformationSurvey PGx is designed for laboratories performing genetic testing for predicting drug response. Each sample willinclude 25µg of extracted DNA. Interpretive challenges will also be included in the context of the clinical casescenario. Participants may perform testing for CYP2C19, CYP2C9, CYP2D6, UGT1A1, and VKORC1 on each sample.

Pharmacogenetics PGx

Endocrinology 71


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Analyte ING Challenges per ShipmentC-Peptide ! 3Gastrin ! 3Insulin ! 3Parathyroid Hormone (PTH) ! 3

Product InformationEach shipment includes three 5.0-mL vials of lyophilized specimens.


Insulin, Gastrin, C-Peptide, PTH Assays ING

Analyte EPO Challenges per ShipmentErythropoietin ! 2



Erythropoietin EPO

Analyte RAP Challenges per ShipmentAldosterone ! 3Renin ! 3

Product InformationSurvey RAP is designed for participants performing aldosterone and renin testing. Each shipment of RAP will includethree 2.0-mL vials of lyophilized specimens.


Renin and Aldosterone RAP

72 Endocrinology



Analyte FP FPX Challenges per ShipmentAlpha-fetoprotein (AFP), serum ! ! 5Alpha-fetoprotein (AFP), amniotic fluid ! ! 2Dimeric inhibin A (DIA) ! ! 5Estriol, unconjugated (uE3) ! ! 5Human chorionic gonadotropin (hCG), quantitative ! ! 5

Product InformationSurvey FP is designed for laboratories that use AFP to screen for neural tube defects and for fetal Down Syndromeusing multiple marker combinations. Laboratories that require additional serum should order Survey FPX.

" AFP, uE3, and hCG " AFP, uE3, hCG, and DIA

To be in compliance with federal proficiency testing requirements, laboratories that use AFP or hCG for applicationsother than prenatal screening (tumor marker or pregnancy testing) should refer to the Ligand Assay Surveys K or KKon page 61.

Each shipment will include five 1.0-mL liquid serum specimens consisting of normal, borderline-abnormal, andelevated levels for AFP, uE3, inhibin, and hCG analysis; and two 1.0-mL simulated amniotic fluid specimens for AFPanalysis. Each shipment of FPX will include ten 1.0-mL liquid serum specimens and two 1.0-mL simulated amnioticfluid specimens.


Product Fulfillment Group FP

FBR/CAP Maternal Screening FP, FPX

Analyte FF Challenges per ShipmentFetal fibronectin ! 2

Product InformationEach shipment of Survey FF will include two 1.2-mL specimens.

Fetal Fibronectin FF

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8BLOOD GAS, CRIT ICAL CARE,

AND OXIMETRY

Toxi

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CAP Forensic Drug Testing (FDT) Laboratory Accreditation ProgramThe core of the CAP Laboratory Accreditation Program is built on inspections thatare designed and maintained by experts in the field of forensic laboratory science.This type of process provides you with the opportunity to be inspected byexperienced and knowledgeable laboratory professionals who are in tune withthe changing needs of the forensic community.

The College of American Pathologists (CAP), together with the American Associationfor Clinical Chemistry (AACC), identified the need for an accreditation programdesigned specifically for laboratories engaged in drug testing. In response, the CAPdeveloped the Forensic Drug Testing (FDT) Laboratory Accreditation Program forlaboratories performing nonmedical drug testing. Participation in the CAP FDTLaboratory Accreditation Program requires that forensic laboratories successfullycomplete the challenges in three consecutive shipments of the AACC/CAP ForensicUrine Drug Testing (UDC) Survey or a CAP-approved proficiency program andprovide evidence of on-site, confirmatory testing for the following substances:amphetamine, methamphetamine, codeine, total morphine, benzoylecgonine,phencyclidine, and delta-9-THC-COOH.

The College encourages all forensic laboratories to participate in the FDTaccreditation program to raise the bar of excellence in the industry and to providethe highest quality laboratory results possible.

Blood Gas, Critical Care, and Oximetry 73


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Blood Gas, Critical Care, and OximetryAnalytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS).

Analyte AQ AQ2 O Q Challenges per ShipmentCalcium, ionized ! ! ! 2Chloride ! ! ! 5Hematocrit ! ! 5Hemoglobin, estimated ! ! 5Lactate ! ! 2Magnesium, ionized ! ! 2PCO22 ! ! ! ! 5pH ! ! ! ! 5PO22 ! ! ! ! 5Potassium ! ! ! 5Sodium ! ! ! 5tCO2 ! ! 5Creatinine ! 5Glucose ! ! 5Urea ! 5

Critical Care Aqueous and Fluorocarbon Blood Gas AQ, AQ2, O, Q

Product InformationFor clarification of the proficiency testing material type required by your instrument, please contact your instrumentmanufacturer.

Surveys AQ and AQ2 are designed for electrolyte and blood gas analyzers that perform chemistry analysis and hematocrit by conductivity requiring aqueous materials.

Survey O is designed for laboratories performing blood gas analysis with instruments requiring fluorocarbon specimens.

Each shipment of Surveys AQ and AQ2 will include ten (five in duplicate) 2.5-mL ampules of aqueous specimens andten (five in duplicate) 2.5-mL ampules for hematocrit testing.

Each shipment of Survey O will include ten (five in duplicate) 2.0-mL fluorocarbon specimens.

Survey Q will include ten (five in duplicate) 2.0-mL fluorocarbon specimens for blood gas analysis and five 5.0-mLserum specimens for chemistry analysis.

Note: Two sets of data can be reported in each of these Surveys. For laboratories reporting two sets of data, the first set of results will be used to meet federal regulatory requirements.

Product Fulfillment Group AQ (AQ, AQ2) Product Fulfillment Group OQ (O, Q)

Note: Lactate and Creatinine are no longer offered in Survey Q.

74 Blood Gas, Critical Care, and Oximetry



Analyte SO Challenges per ShipmentCarboxyhemoglobin ! 5Hematocrit, estimated ! 5Hemoglobin, total ! 5Methemoglobin ! 5Oxyhemoglobin ! 5

Blood Oximetry SO

Product InformationThese specimens are not compatible with the Oxicom-2000, -2100, or -3000 whole blood oximeters. Two sets of datacan be reported in Survey SO. For laboratories reporting two sets of data, the first set of results will be used to meetfederal regulatory requirements. Each shipment will include five 1.7-mL ampules of stabilized human hemoglobinsolution.

9TOXICOLOGY

Toxi

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CAP Forensic Drug Testing (FDT) Laboratory Accreditation ProgramThe core of the CAP Laboratory Accreditation Program is built on inspections thatare designed and maintained by experts in the field of forensic laboratory science.This type of process provides you with the opportunity to be inspected byexperienced and knowledgeable laboratory professionals who are in tune withthe changing needs of the forensic community.

The College of American Pathologists (CAP), together with the American Associationfor Clinical Chemistry (AACC), identified the need for an accreditation programdesigned specifically for laboratories engaged in drug testing. In response, the CAPdeveloped the Forensic Drug Testing (FDT) Laboratory Accreditation Program forlaboratories performing nonmedical drug testing. Participation in the CAP FDTLaboratory Accreditation Program requires that forensic laboratories successfullycomplete the challenges in three consecutive shipments of the AACC/CAP ForensicUrine Drug Testing (UDC) Survey or a CAP-approved proficiency program andprovide evidence of on-site, confirmatory testing for the following substances:amphetamine, methamphetamine, codeine, total morphine, benzoylecgonine,phencyclidine, and delta-9-THC-COOH.

The College encourages all forensic laboratories to participate in the FDTaccreditation program to raise the bar of excellence in the industry and to providethe highest quality laboratory results possible.

Analyte* UT Challenges per ShipmentGroup I Drugs ! **Group II Drugs ! **Group III Drugs ! **Group IV Drugs ! **Group V Drugs ! **Group VI Drugs ! **Group VII Drugs ! **Group VIII Drugs ! **

Toxicology 75


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Urine Toxicology UT

*See next page for a listing of analytes included in each Drug Group.

**Each mailing of Survey UT will include challenges with analytes from Drug Group I, as well as from one ormore of Drug Groups II-VIII.

Product InformationSurvey UT is designed for laboratories performing qualitative urine drug analysis with confirmation testing.Laboratories performing only immunoassay screening techniques should consider enrolling in the AACC/CAP UrineDrug Testing (Screening) Survey UDS featured on page 79. Each shipment will include five 50.0-mL liquid urinespecimens.

ToxicologyAnalytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS).

76 Toxicology



Urine Toxicology UT Drug Group ListingGroup IAcetaminophenAminesAmphetamineAmphetamine GroupBenzoylecgonineCannabinoidsCocaethyleneCocaineCodeine*Delta-9-THC-COOHEthanolLysergic acid diethylamide (LSD)MethamphetamineMorphineOpiate GroupPhencyclidineSalicylates

Group II6-MonoacetylmorphineBrompheniramineBuprenorphineChlorpheniramineDextromethorphanDiphenhydramineFentanyl*HydrocodoneHydromorphoneLevorphanolMeperidine*Methadone*NorcodeineNormeperidineNorpropoxypheneOpiate GroupOxycodoneOxymorphonePentazocinePropoxypheneQuinine/QuinidineTramadol

Group IIIAmitriptylineAmoxapineChlorpromazine

Clomipramine*ClozapineCyclobenzaprineDesipramineDoxepin*Fluoxetine*HaloperidolImipramineLoxapineMaprotilineNorcyclobenzaprineNordoxepinNorfluoxetineNorsertralineNortriptylineSertraline*Trazodone

Group IVAlprazolam*Benzodiazepine GroupCarbamazepine*Carbamazepine epoxideChlordiazepoxide*Clonazepam*DiazepamFlurazepam*LorazepamNordiazepamOxazepamTemazepam

Group VAmobarbitalBarbiturate GroupButalbitalCarbamazepineCarisoprodolDoxylamineGamma hydroxybutyrate (GHB)KetamineMeprobamatePentobarbitalPhenobarbitalPhenytoinSecobarbital

Group VIAmphetamine GroupBrompheniramineChlorpheniramineCotinineDiphenhydramineEcgonine methyl esterEphedrineMethylenedioxyamphetamine (MDA)Methylenedioxymethamphetamine

(MDMA)Nicotine*PhenethylaminePheniraminesPhenterminePhenylpropanolaminePseudoephedrineStrychnine

Group VIICimetidineCyclobenzaprineHydroxyzineIbuprofenLidocaineN-acetylprocainamideNaproxenProcainamideRanitidineTheophyllineTrazodoneVerapamil*

Group VIIIAcetoneEthanolEthylene glycolIsopropanolMethanol

*and/or metabolite(s)

Analyte T Challenges per ShipmentDrugs* ! 5

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* See next page for a listing of possible analytes.

Toxicology T

Product InformationSurvey T is designed for laboratories performing qualitative and quantitative analysis of drugs on serum andqualitative analysis on urine specimens, with confirmation testing. Laboratories performing only immunoassayscreening techniques for serum should consider enrolling in the Serum Drug Screening Survey SDS featured onpage 81. Each shipment of Survey T will include a total of five specimens, consisting of 20.0-mL lyophilized serumand 50.0-mL liquid urine specimens. Challenges will include a mix of analytes from the list of drugs on the next page.

Urine Toxicology Carry Over SurveyUTCO Survey participants:

! Will be able to evaluate instrument sample probe carry over

! Receive instuctions to calculate carry over without waiting for returned results

! Can purchase multiple kits to use anytime to ensure quality results

Please refer to page 105 in Chapter 11.

78 Toxicology



6-MonoacetylmorphineAcetaminophenAcetoneAlpha hydroxyalprazolamAlprazolam*AmobarbitalAmoxapine*AmphetamineAmphetamine GroupAmitriptylineAtenololAtropineBarbiturate GroupBenzodiazepine GroupBenzoylecgonineBrompheramineBuprenorphine*BupropionCannabinoidsCarbamazepine*CarisoprodolChlorpheniramineCimetidineCitalopramClomipramineClonazepam*CocaethyleneCocaineCodeine*Cotinine*CyclobenzaprineDelta-9-THCDelta-9-THC-COOHDesipramineDextromethorphanDiazepamDigoxinDihydrocodeineDiltiazemDiphenhydramineDoxepin*Ecgonine methyl esterEphedrine

Ephedrine/PseudoephedrineEthanolEthylene glycolFamotidineFentanyl*Fluoxetine*Flunitrazepam*Flurazepam*HydrocodoneHydromorphoneHydroxyzineIbuprofenImipramineIsopropanolKetamine*LamotrigineLidocaineLithiumLorazepamLoxapineMaprotilineMeprobamateMeperidine*MesoridazineMethadone*Methadone metabolite (EDDP)MethanolMethamphetamineMethylenedioxyamphetamine (MDA)Methylenedioxymethamphetamine

(MDMA)MirtazapineMorphine*N-acetylprocainamide (NAPA)NaproxenNefazodoneNicotineNorchlordiazepoxideNorcodeineNordiazepamNordoxepinNorfentanylNorfluoxetine

NormeperidineNorpropoxypheneNorsertralineNortriptylineNorverapamilOlanzapineOpiate GroupOxaprozinOxazepamOxycodoneOxymorphonePentazocinePentobarbitalPhencyclidinePheniraminePhenobarbitalPhenothiazinePhenterminePhenylpropanolaminePhenytoinProcainamidePropoxyphene*PseudoephedrinePyrilamineQuetiapineQuinidineQuinineRanitidineSalicylatesSecobarbitalSertraline*StrychnineTemazepamTheophyllineThioridazineTramadol*TrazodoneTrichloroethanolTricyclic GroupTrimipramineTripelennamineValproic acidVerapamil*

Toxicology T Drug Listing

*and/or metabolite(s)

Challenges per ShipmentAnalyte UDS UDS6Acetaminophen NEW 5 3Amphetamine Group 5 3Barbiturate Group 5 3Benzodiazepine Group 5 3Benzoylecgonine/cocaine metabolites 5 3Buprenorphine NEW 5 3Delta-9-THC-COOH 5 3Ethanol 5 3Lysergic acid diethylamide (LSD) 5 3Methadone 5 3Methadone metabolite (EDDP) NEW 5 3Methaqualone 5 3Methylenedioxymethamphetamine (MDMA) 5 3Opiate Group 5 3Oxycodone 5 3Phencyclidine 5 3Propoxyphene 5 3Tricyclic Group 5 3Total Challenges per year 15 6

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AACC/CAP Urine Drug Testing (Screening) UDS, UDS6

Product InformationSurveys UDS and UDS6 are designed for laboratories performing drugs-of-abuse testing on urine specimens, usingimmunoassay or other screening (non-confirmation) techniques only. Laboratories using other techniques shouldconsider enrolling in the Urine Toxicology Survey UT featured on page 75. Each shipment of UDS will include five10.0-mL liquid urine specimens, for a total of 15 challenges per year. Each shipment of UDS6 will include three10.0-mL liquid urine specimens in two shipments, for a total of six challenges per year. Subscribers will also receivethe Clinical & Forensic Toxicology News quarterly newsletter produced by the AACC.

Each set of UDSM ordered will consist of five 10.0-mL liquid urine specimens.

Together, the CAP and the American Association for Clinical Chemistry (AACC) provide proficiency testing programs toenhance the quality of services provided by specialized chemistry laboratories. CAP committees provide the forum for theexchange of scientific expertise that supports the AACC/CAP programs. Programs are offered for alcohol/volatiles, bloodlead, and urine drug testing for drugs of abuse.

URINE DRUG TESTING (UDS, UDS6)VALIDATED MATERIAL (UDSM)

80 Toxicology


Analyte UDC Challenges per Shipment6-Monoacetylmorphine ! 10Alpha-hydroxyalprazolam ! 10Amphetamine ! 10Benzoylecgonine ! 10Buprenorphine ! 10Butalbital ! 10Codeine ! 10Creatinine ! 10Delta-9-THC-COOH ! 10Hydrocodone ! 10Hydromorphone ! 10Lorazepam ! 10Methadone ! 10Methadone metabolite (EDDP) NEW ! 10Methamphetamine ! 10Methaqualone ! 10Methylenedioxyamphetamine (MDA) ! 10Methylenedioxymethamphetamine (MDMA) ! 10Morphine ! 10Norcodeine ! 10Nordiazepam ! 10Norpropoxyphene ! 10Oxazepam ! 10Oxycodone ! 10Oxymorphone ! 10pH ! 10Phencyclidine ! 10Phenobarbital ! 10Propoxyphene ! 10Secobarbital ! 10Specific Gravity ! 10Temazepam ! 10

AACC/CAP Forensic Urine Drug Testing(Confirmatory) UDC

Product InformationSurvey UDC is designed for laboratories that perform both screening and confirmatory testing, including quantitation,for drugs of abuse in urine specimens. Laboratories are asked to report creatinine, pH, and specific gravity for eachspecimen to ensure specimen adulteration has not occurred. Participants successfully passing three consecutivequarterly UDC Surveys are eligible to apply for the CAP Forensic Drug Testing Accreditation Program. Each shipmentwill include ten 50.0-mL liquid urine specimens. Subscribers to Survey UDC will receive the Clinical & ForensicToxicology News quarterly newsletter from the AACC.


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Analyte SDS Challenges per ShipmentAcetaminophen (quantitative and qualitative) ! 3Acetone (qualitative and semiquantitative) ! 3Barbiturate Group (qualitative) ! 3Benzodiazepine Group (qualitative) ! 3Salicylate (quantitative and qualitative) ! 3Total tricyclic antidepressants (qualitative) ! 3

Serum Drug Screening SDS

Product InformationSurvey SDS is designed for laboratories performing qualitative drugs-of-abuse testing on serum specimens, usingimmunoassay or other screening techniques. Laboratories performing total tricyclic antidepressant testing byquantitative methods should enroll in TDM (Special) Survey ZT, found on page 50. Quantitative drugs-of-abuse testingfor acetaminophen and salicylates may also be reported. Each shipment will include three 2.0-mL serum specimens.

82 Toxicology



AL1 AL2Analyte Whole Blood Serum Challenges per ShipmentAcetone ! ! 5Ethanol ! ! 5Isopropanol ! ! 5Methanol ! ! 5SERUM ALCOHOL/VOLATILESVALIDATED MATERIAL (AL2M)

Product InformationSurveys AL1 and AL2 are intended for quantitative methods only. Laboratories performing serum acetone byqualitative and semiquantitative methods should consider enrolling in the Serum Drug Screening Survey SDS, or theKetones Survey KET, featured on page 57. Each AL1 shipment will include five 5.0-mL liquid whole blood specimens.Each AL2 shipment will include five 5.0-mL liquid serum specimens. The Whole Blood Alcohol/Volatiles Survey AL1is approved by the American Society of Crime Laboratory Directors/Laboratory Accreditation Board/ProficiencyReview Committee (ASCLD/LAB/PRC).

Each set of AL2M ordered will consist of five 5.0-mL liquid serum specimens.

AACC/CAP Alcohol/Volatiles AL1, AL2

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Analyte CD Challenges per ShipmentBeta-2-microglobulin, urine ! 3Cadmium, urine ! 3Cadmium, whole blood ! 3Creatinine, urine ! 3

Cadmium CD

Product InformationEach shipment will include three 5.0-mL whole blood specimens and three 15.0-mL liquid urine specimens.

Analyte BL Challenges per ShipmentLead ! 5BLOOD LEAD

VALIDATED MATERIAL (BLM)

Product InformationThis Survey meets the Occupational Safety and Health Administration (OSHA) requirements for proficiency testing forlaboratories performing employee blood lead testing for occupational hazards [OSHA lead standards-29 CFR1910.1025(j)(C)(iii)]. Participants may request that their results be sent to OSHA for approval as a blood leadtesting site by contacting a CAP Customer Contact Center Representative at 800-323-4040 option 1. Each shipmentwill include five 6.0-mL liquid nonhuman whole blood specimens.

Each set of BLM ordered will consist of five 6.0-mL liquid nonhuman whole blood specimens.

AACC/CAP Blood Lead BL

84 Toxicology



Analyte FTC Challenges per ShipmentDrugs* ! 4

Product InformationThis program is designed for crime laboratories and hospital laboratories that have forensic toxicology divisions thatperform qualitative and quantitative analysis of drugs in whole blood specimens. The Whole Blood ForensicToxicology Program is approved by the American Society of Crime Laboratory Directors/LaboratoryAccreditation Board/Proficiency Review Committee (ASCLD/LAB/PRC).

Each shipment will include three 20.0-mL lyophilized human whole blood specimens and one 50.0-mL lyophilizedurine specimen. Challenges will include a mix of analytes from the list of drugs below.

* See below for a listing of possible analytes.

* and/or metabolite(s)

Whole Blood Forensic Toxicology FTC

Whole Blood Forensic Toxicology FTC Drug Listing

6-Monoacetylmorphine (6-MAM)7-AminoflunitrazepamAcetaminophenAlprazolamAmitriptylineAmphetamineBenzoylecgonineButalbitalCarisoprodolCocaethyleneCocaineCodeineCyclobenzaprineDelta-9-THCDelta-9-THC-COOHDesipramineDiazepam

DiphenhydramineDiphenylhydantoin

(phenytoin)DoxepinEcgonine methyl esterEphedrineFentanylFluoxetineFlurazepam*Gamma-hydroxybutyrate

(GHB)HydrocodoneHydromorphoneImipramineKetamineLorazepam

Lysergic acid diethylamide(LSD)

Meperidine*MeprobamateMethadoneMethadone metabolite

(EDDP)MethamphetamineMethylenedioxyampheta-

mine (MDA)Methylenedioxymetham-

phetamine (MDMA)Morphine*NordiazepamNordoxepineNorfluoxetine

NorpropoxypheneNortriptylineOxazepamOxycodoneOxymorphoneParoxetinePhencyclidinePhenobarbitalPhenterminePropoxyphenePseudoephedrineSecobarbitalSertralineTemazepamTramadolTrazodoneZolpidem

10ACCURACY BASED SURVEYS

The Surveys in this chapter use materials prepared frompooled native clinical samples that have had minimalalteration during preparation. The materials have hadtarget values assigned using high-level referencemethods. These Surveys are expected to be commutablewith native clinical samples, and the results can be usedto verify the accuracy of routine methods.

Accu

racy

Base

dSu

rvey

s

Accuracy Based SurveysSeveral Surveys have been developed by the College of American Pathologiststo help your laboratory measure the accuracy of your assays. These accuracy-based Surveys use challenge specimens that are free from matrix effects andhave target values traceable to certified reference material.

A high level of testing accuracy is clinically important, especially for analytessuch as serum creatinine, lipids, glycohemoglobin, and bilirubin in neonates.This testing accuracy is especially important to patients who are managed usingnational guidelines. These guidelines require laboratory testing that demonstrateclose comparisons with results obtained using the reference methods that wereused to develop the national guidelines.

By participating successfully in a CAP accuracy-based Survey, a laboratory caneasily determine how well its assay results compare with national referencemethod results.

Proficiency testing (PT) and accuracy-based Surveys are designed for differentpurposes. PT measures the proficiency with which a laboratory uses its testsystems and enables the laboratory to satisfy regulatory and accreditationrequirements. On the other hand, accuracy-based Surveys enable a laboratoryto measure the “trueness” of critical assays in situations where a high level oftesting accuracy makes a clinical difference.

As PT challenge specimens are not tested using these reference methods andmay contain stabilizers that can impact instrument performance, PT Surveyscannot be used for the purpose of measuring critical assay accuracy. PT Surveysshould, in fact, be used in conjunction with accuracy-based Surveys to ensurethe highest level of accuracy.

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Accuracy Based Surveys

Analyte LN24Creatinine !

Creatinine Accuracy Calibration Verification/Linearity LN24

Product InformationThe LN24 Survey focuses on values for creatinine at the range from 0.5-4.0 mg/dL. Each shipment of LN24 willconsist of six 1.0-mL liquid fresh frozen serum specimens.

Product will ship within two days of the specified ship date.

The College of American Pathologists and the National Kidney Disease Education Program have an initiative to producea gold standard to harmonize clinically reported creatinine values. This initiative is analogous to what the federal healthagencies and the clinical laboratory community did to improve the accuracy of cholesterol and glycohemoglobintesting.

86 Accuracy Based Surveys



Analyte CFS Challenges per ShipmentAlbumin ! 1Bilirubin ! 1Chloride ! 1Cortisol ! 1Creatinine ! 1Glucose ! 1Iron ! 1Magnesium ! 1Phosphorus ! 1Potassium ! 1Protein, total ! 1Sodium ! 1Thyroxine (T4), total ! 1Urea Nitrogen (BUN) ! 1Uric acid ! 1

Commutable Frozen Serum CFS

Note: No claims can be made for the stability of the sample if thawed and refrozen.

Product InformationThis product will provide laboratories the opportunity to purchase commutable frozen serum material for use inestablishing traceability of their analytical measurement systems. Data need not be returned to the CAP.

Each shipment includes one 10.0-mL frozen neat serum sample. Laboratories will also receive a table of thereference measurement procedures and values. Note: Product can be ordered at any time during the year.

Survey CFS ships the first Monday of each month.

continued on page 87

The Commutable Frozen Serum (CFS) product will provide laboratories the opportunity to purchase material for use inestablishing traceability of their analytical measurement systems.

This material was prepared using a slightly modified CLSI C37-A preparation protocol and was included as specimenC-02 in the 2003 Comprehensive Chemistry Survey, in the C-C (third) mailing. Values for 15 measurements have beenassigned using reference measurement procedures.

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RMP Method RMP Target RMP TargetAnalyte (number of labs)"" N Value Value SEM##

Albumin Bromcresol green (2) 9 4.12 g/dL 0.011 g/dL

Bilirubin Jendrassik-Grof (5) 14 0.36 mg/dL 0.015 mg/dL

Chloride Mass spectrometry (1); 12 104.7 mmol/L 0.27 mmol/Lamperometric (3)

Cortisol Mass spectrometry (2) 20 13.55 µg/dL 0.067 µg/dL

Creatinine Mass spectrometry (2) 12 0.90 mg/dL 0.003 mg/dL

Glucose Mass spectrometry (1); 14 98.5 mg/dL 0.20 mg/dLHexokinase (3)

Iron Ferrozine (3) 8 65.4 µg/dL 0.90 µg/dL

Magnesium Atomic absorption (2) 6 1.94 mg/dL 0.016 mg/dL

Phosphorus Molybdate (3) 8 3.25 mg/dL 0.016 mg/dL

Potassium Flame photometry (3) 9 4.38 mmol/L 0.008 mmol/L

Protein, total Biuret (3) 9 7.16 g/dL 0.007 g/dL

Sodium Flame photometry (3); 12 140.7 mmol/L 0.16 mmol/Lgravimetry (1)

Thyroxine (T4), total Mass spectrometry (2) 15 6.39 µg/dL 0.038 µg/dL

Urea Nitrogen (BUN) Mass spectrometry (1); 11 12.18 mg/dL 0.036 mg/dLurease (2)

Uric acid Mass spectrometry (2); 29 5.38 mg/dL 0.010 mg/dLuricase (4)

Commutable Frozen Serum, continued

"Mass spectrometry is the primary RMP for chloride, glucose, urea, and uric acid, and gravimetry for sodium; but for these analytes other accepted RMPs were also used to determine a target value. An outlier test was performed to determine that results were not different when two RMPs were used to determine a target value.#SEM is standard error of the mean.

The following table of reference measurement procedures (RMP) and target values will be sent with each order.

88 Accuracy Based Surveys



Analyte ABL Challenges per ShipmentApolipoprotein A1 ! 3Apolipoprotein B ! 3Cholesterol* ! 3HDL Cholesterol* ! 3LDL Cholesterol* ! 3Lipoprotein (a) NEW ! 3Triglyceride* ! 3

Product InformationEach shipment of Survey ABL will contain three 2.0-mL serum specimens. *Accuracy based grading will use the target values that are based upon the Centers for Disease Control andPrevention (CDC) reference method by the Lipid Reference Laboratory, Clinical Chemistry Branch, CDC, Atlanta,Georgia. Product will ship within two days of the specified ship date.

Accuracy Based Lipid Survey ABL

Analyte GH2 Challenges per ShipmentGlycohemoglobin (HbA1c) ! 3

Product InformationEach shipment will include three 0.7-mL liquid human whole blood specimens. Survey GH2 results will be gradedagainst the reference method used in the National Glycohemoglobin Standardization Program.

Glycohemoglobin GH2

Analyte NB NB2* Challenges per ShipmentBilirubin, direct ! ! 2Bilirubin, total ! ! 5/2

Product InformationSurveys NB and NB2 includes decision points for use in phototherapy and/or exchange transfusion and is designed torepresent clinical conditions observed in neonates.

Each shipment of Survey NB will include five 2.0-mL serum specimens. Each shipment of Survey NB2 will include two2.0-mL serum specimens.

One specimen in each mailing of NB and NB2 will be human-based serum. A second set of grading criteria, ie,comparison to the value assigned using the reference method procedure (Clin Chem. 1985;31:1779-1789), will beapplied to this specimen for educational purposes only.

Neonatal Bilirubin NB, NB2

*Note: Survey NB2 must be ordered in conjunction with a 5 challenge total bilirubin proficiency testing product in order tomeet CMS requirements

11CALIBRATION

VERIFICATION/LINEARITY ANDINSTRUMENTATION

New for 2009! The Hematology (LN9/LN9ER), Ammonia (LN32), and Serum

Myoglobin (LN33) Calibration Verification/Linearity Surveys have beenadded to the LN ExpressSM menu.

! Turnaround time for Surveys offered on the LN ExpressSM menu hasbeen reduced from four to two days.

Hem

atol

ogy

and

Clin

ical

Mic

rosc

opy

Hematology ......................................................................107

Clinical Microscopy ..........................................................115

Subdisc ip l ines

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Calibration Verification/Linearity Survey Corresponding Survey Survey Validated MaterialLN1-Chemistry CVL C1, C3, C3X, CZ, CZX, CZ2, CZ2X LN2ERVMLN1ER-Chemistry Extended Range CVL C1, C3, C3X, CZ, CZX, CZ2, CZ2X LN2ERVMLN2-Chemistry/Lipid/Enzyme CVL C1, C3, C3X, CZ, CZX, CZ2, CZ2X LN2ERVMLN2ER-Chemistry/Lipid/Enzyme/Extended Range CVL C1, C3, C3X, CZ, CZX, CZ2, CZ2X LN2ERVMLN3-TDM CVL CZ, CZX, CZ2, CZ2X, Z CZVMLN5-Ligand Assay CVL K, KK LLMLN6-Urine Chemistry CVL U LUMLN7-Immunology CVL IG -LN8-Reproductive Endocrinology CVL Y, YY -LN9-Hematology CVL FH Series, HE Series -LN9ER-Hematology Extended Range CVL FH Series, HE Series -LN11-Serum Ethanol CVL AL2 -LN11ER-Serum Ethanol Extended Range CVL AL2 -LN12-C-Reactive Protein CVL CRP -LN13, LN13C-Blood Gas/Critical Care CVL AQ, AQ2 -LN14-Whole Blood Ethanol CVL AL1 -LN15-Glycohemoglobin CVL GH2 -LN16-Homocysteine CVL HMS -LN17-Whole Blood Glucose CVL WBG, WB2 -LN18-Reticuloctye CVL RT, RT2, RT4 -LN19-Reticulocyte CVL RT3 (Coulter GenS and

LH700 series only)LN20-Urine albumin CVL U (Urine albumin and Creatinine) -LN21-High-Sensitivity C-reactive Protein CVL hsCRP -LN22-Flow Cytometry CVL FL -LN23-Prostate-Specific Antigen CVL K (PSA) -LN24-Creatinine Accuracy CVL C1, C3, C3X, CZ, CZX,CZ2, CZ2X -LN25-Troponin I CVL TRP, CRT, CRTI -LN27-Troponin T CVL TRP, CRT, CRTI -LN30-B-type Natriuretic Peptides CVL BNP -LN31-Immunosuppressive Drugs CVL CS -LN32-Ammonia CVL C3, C3X, CZ, CZX, CZ2, CZ2X -LN33-Serum Myoglobin CVL CARM, CRT, CRTI -LN34-CA-125 CVL TM (CA-125) -

Your Total Calibration Verification/Linearity (CVL) Solution

Calibration Verification/Linearity and InstrumentationAnalytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services

Provides individual evaluation reports by analyte, executive summary report, and graphical plots for linearity and calibration verification.

90 Calibration Verification/Linearity and Instrumentation



Calibration Verification/Linearity Surveys advantages:

! Now receive your Linearity results in two days (business days) with LN Expresssm

! Receive human serum-based liquid specimens that cover broad analyte ranges to challenge assays from near zero

to the top of the analytical measurement range for most analytes and methods

! Access a comprehensive selection of analytes and programs to encompass a broad testing menu

! Satisfy the requirements for scheduled verification of the analytical measurement range of the CAP Laboratory

Accreditation Program and the CLIA calibration verification under 42 CFR493.1255(b)(3) for most analytes

! Use a consistent analytical approach for the assessment of the method linearity and calibration agreement with

your peer group

! Get a custom report with an Executive Summary for a quick overview of the performance, a comprehensive

evaluation report with specific analyte information, and calibration verification and linearity graphs

! Receive a complimentary CVL User’s Guide to assist and educate you on how to interpret your results

! Get a customized report that provides a summary of laboratory performance that includes peer group statistics and

enhanced diagnostic information for early insight into potential problems.

Note: The College of American Pathologists Laboratory Accreditation Program requires an additional calibrationverification process for methods calibrated less frequently than once every six months. Please review the inspectionchecklist for information about suitable verification material for any method that is calibrated less often than atsix-month intervals. The Calibration Verification/Linearity Surveys are designed to assess agreement of a laboratorywith the method manufacturer’s calibration settings, but do not validate accuracy traceable to reference methods.

Please see the CAP Instrumentation Resource Committee Web site at www.cap.org or contact a CAP Customer ContactCenter Representative at 800-323-4040 option 1 for additional information and a listing of the specific analyte rangestargeted in these Surveys.

Improve the reliability of your patient results with CAP Survey ValidatedMaterials

Use the same material that is sent in the Surveys Program to:

! Identify and troubleshoot instrument/method problems

! Correlate results with other laboratories or instruments

! Document correction of problems identified in Surveys

! Utilize as an alternative external quality control material with confirmed results

! Identify potential proficiency testing failures

Results are readily available in the Survey Participant Summary that is included with each Survey Evaluation Report.



www.cap.org

Analyte LN1 LN1ER LN2 LN2ERAlbumin ! ! ! !

Bilirubin, direct* ! ! ! !

Bilirubin, total* ! ! ! !

Calcium* ! ! ! !

Chloride ! ! ! !

CO2* ! ! ! !

Creatinine ! ! ! !

Glucose ! ! ! !

Iron ! ! ! !

Magnesium ! ! ! !

Osmolality* ! ! ! !

Phosphorus ! ! ! !

Potassium ! ! ! !

Protein, total ! ! ! !

Sodium ! ! ! !

Urea ! ! ! !

Uric Acid ! ! ! !

Alanine aminotransferase (ALT/SGPT) ! !

Alkaline phosphatase (ALP) ! !

Amylase ! !

Aspartate aminotransferase (AST/SGOT) ! !

Cholesterol* ! !

CK2 (MB) ! !

Creatine kinase (CK) ! !

Gamma glutamyl transferase (GGT) ! !

HDL cholesterol* ! !

Lactate dehydrogenase (LD) ! !

Lipase ! !

Triglycerides* ! !

Chemistry/Lipid/EnzymeCalibration Verification/Linearity

LN1**, LN1ER, LN2**, LN2ER

Product InformationLN1 and LN2 participants mayreport diluted specimen results.

Surveys LN1 and LN2 correspondto CAP Chemistry Surveys C1, C3,C3X, CZ, CZX, CZ2, and CZ2X.Each shipment of Surveys LN1and LN2 will contain six 10.0-mLliquid serum specimens and six3.0-mL liquid serum specimensfor evaluation of direct and totalbilirubin. Each shipment ofSurvey LN2 will also contain one20.0-mL and two 10.0-mL liquidlipid serum specimens fromwhich additional admixtures willbe prepared. Survey LN1ER willinclude all specimens in LN1 andan additional high vial forparticipants that need higheranalyte ranges than currentlyavailable in Survey LN1. SurveyLN2ER will include all specimensin LN2 and an additional highvial for participants that needhigher analyte ranges thancurrently available in Survey LN2.

Each set of LN2ERVM orderedwill contain all the specimensincluded in LN2ER.

CVL CHEMISTRY/LIPID/ENZYMEVALIDATED MATERIAL (LN2ERVM)

*These analytes are not available for extended range reporting.** LN Express is available for only LN1 and LN2 at this time.

E




CVL LIGAND ASSAY VALIDATED MATERIAL (LLM)

Analyte LN5CEA !

Cortisol !

Ferritin !

Folate !

Human chorionic gonadotropin (hCG) !

T3, total (Triiodothyronine) !

T4, total (Thyroxine) !

Thyroid-stimulating hormone (TSH) !

Vitamin B12 !

Ligand Assay CalibrationVerification/Linearity LN5

CVL TDM VALIDATED MATERIAL (LDM)

Analyte LN3Acetaminophen !

Amikacin !

Carbamazepine !

Digoxin !

Gentamicin !

Lidocaine !

Lithium !

N-acetylprocainamide (NAPA) !

Phenobarbital !

Phenytoin !

Primidone !

Procainamide !

Quinidine !

Salicylate !

Theophylline !

Tobramycin !

Valproic acid !

Vancomycin !

TDM Calibration Verification/Linearity LN3

Product InformationLN5 participants may reportdiluted specimen results. SurveyLN5 corresponds to CAP LigandAssay (General) Surveys K andKK. Each shipment of SurveyLN5 will include five4.0-mL liquid serum specimens.

Each set of LLM ordered willconsist of five 4.0-mL liquidserum specimens.

Product InformationLN3 participants may reportdiluted specimen results. SurveyLN3 corresponds to CAP GeneralChemistry and Therapeutic DrugMonitoring Surveys CZ, CZX,CZ2, CZ2X, and Z. Each ship-ment of Survey LN3 will includesix 4.0-mL liquid serum speci-mens.

Each set of LDM ordered willconsist of six 4.0-mL liquidserum specimens.

E

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CVL URINE CHEMISTRY VALIDATED MATERIAL (LUM)

Analyte LN6Amylase !

Calcium !

Chloride !

Creatinine !

Glucose !

Osmolality !

Phosphorus !

Potassium !

Protein, total !

Sodium !

Urea !

Uric acid !

Urine Chemistry CalibrationVerification/Linearity LN6

Product InformationLN6 participants may reportdiluted specimen results.Survey LN6 corresponds to CAPUrine Chemistry (General)Survey U. Each shipment ofSurvey LN6 will include 154.0-mL liquid urine specimens.

Each set of LUM ordered willconsist of 15 4.0-mL liquidurine specimens.

Analyte LN7Alpha-1-antitrypsin !

Complement C3 !

Complement C4 !

IgA !

IgG !

IgM !

Transferrin !

Immunology CalibrationVerification/Linearity LN7

Product InformationLN7 participants may reportdiluted specimen results.

Survey LN7 corresponds to CAPImmunology (General) SurveyIG. Each shipment of Survey LN7will include five 2.0-mL liquidserum specimens.

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Product InformationLN9 and LN9ER participants may report diluted specimen results.

Surveys LN9 and LN9ER correspond to the CAP Basic Hematology and Hematology Automated Differentials Surveys HEand FH series. Surveys LN9 and LN9ER are compatible with all instruments. The Surveys provide an indicator ofplatelet accuracy at clinical decision levels. The specimens are designed to span the linear range of most automatedhematology instruments. Each shipment of LN9 will include 18 3.0-mL specimens. Survey LN9ER will include allspecimens in LN9 and four additional high vials for participants that need higher platelet and WBC ranges thancurrently available in Survey LN9. All vials have pierceable caps.

Analyte LN9 LN9ERHemoglobin !

Platelet count ! !

RBC count !

WBC count ! !

Hematology Calibration Verification/Linearity LN9, LN9ER

Analyte LN8Estradiol !

Follicle-stimulating hormone (FSH) !

Human chorionic gonadotropin (hCG) !

Luteinizing hormone (LH) !

Progesterone !

Prolactin !

Testosterone !

Reproductive Endocrinology CalibrationVerification/Linearity LN8

Product InformationLN8 participants may report diluted specimen results.

Survey LN8 corresponds to CAP Ligand Assay (Special) Surveys Y and YY. Each shipment of Survey LN8 will includefive 4.0-mL liquid serum specimens.

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Product InformationLN11 and LN11ER participants may report diluted specimen results.

Surveys LN11 and LN11ER correspond to the AACC/CAP Serum Alcohol/Volatiles Survey (AL2). Each shipment willcontain six 3.0-mL liquid serum specimens. Survey LN11ER will include all specimens in LN11 and one additionalhigh vial for participants that need higher analyte ranges than currently available in Survey LN11.

Analyte LN11 LN11ERSerum Ethanol ! !

Serum Ethanol Calibration Verification/Linearity LN11*, LN11ER


Each shipment of Survey LN12 will include six 1.0-mL liquid serum specimens. LN12 participants may report dilutedspecimen results. Note: This Survey is not designed for reporting high-sensitivity C-reactive protein.

Analyte LN12C-reactive protein !

C-reactive Protein Calibration Verification/Linearity LN12

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Analyte LN13 LN13CPCO2 ! !

pH ! !

PO2 ! !

Calcium, ionized !

Chloride !

Glucose !

Lactate !

Magnesium, ionized !

Potassium !

Sodium !

Product InformationSurvey LN13 corresponds to the blood gas component of the CAP Critical Care Aqueous Blood Gas AQ/AQ2 Surveys.Survey LN13C corresponds to the electrolyte and blood gas components of the AQ/AQ2 Surveys. Each shipment ofSurvey LN13 and LN13C will include ten 2.5-mL ampules of aqueous specimens (five in duplicate) for singleinstrument reporting.

Blood Gas/Critical Care Calibration Verification/LinearityLN13, LN13C

Analyte LN14Ethanol !

Product InformationSurvey LN14 corresponds to the AACC/CAP Alcohol/Volatiles Survey (AL1) for whole blood analysis of ethanol. Eachshipment of Survey LN14 will include six 3.0-mL liquid whole blood specimens.

Whole Blood Ethanol Calibration Verification/Linearity LN14E



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Product InformationSurvey LN15 corresponds to the CAP GH2 Survey for glycohemoglobin.

Each shipment of Survey LN15 will include six 0.7-mL liquid human whole blood specimens.

Analyte LN15Glycohemoglobin (HbA1c) !

Glycohemoglobin Calibration Verification/Linearity LN15


Survey LN16 corresponds to the CAP HMS Survey for homocysteine. Each shipment of Survey LN16 will include six1.0-mL liquid serum specimens.

Analyte LN16Homocysteine !

Homocysteine Calibration Verification/Linearity LN16

Product InformationSurvey LN17 corresponds to the CAP WBG/WB2 Surveys for whole blood glucose. With each kit, you may report fromten different ancillary testing sites or instruments. Each shipment of Survey LN17 will include five 2.0-mL liquid wholeblood specimens.

Analyte LN17Whole blood glucose !

Whole Blood Glucose Calibration/Verification Linearity LN17

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Analyte LN20Urine albumin !

Creatinine !




Product InformationSurvey LN18 corresponds to the CAP RT, RT2, RT3, and RT4 Surveys for all instruments except the Coulter GenS andLH700 series. Survey LN19 corresponds to the RT3 Survey for Coulter GenS and LH700 series users only. Eachshipment of Surveys LN18 and LN19 will include five 1.0-mL red blood cell specimens.

Instrument LN18 LN19All instruments except Coulter GenS and LH700 series !

Coulter GenS and LH700 series !

Pierceable caps !

Reticulocyte Calibration Verification/Linearity LN18, LN19


Survey LN20 corresponds to CAP Urine Chemistry Survey U. Each shipment of Survey LN20 will include five5.0-mL liquid urine specimens.

Urine Albumin Calibration Verification/Linearity LN20


Survey LN21 corresponds to the CAP High-Sensitivity C-reactive Protein Survey hsCRP. Each shipment of Survey LN21will include six liquid serum specimens. Survey LN21 is for high sensitivity methods only.

Analyte LN21High-sensitivity C-reactive protein !

High-Sensitivity C-reactive Protein CalibrationVerification/Linearity LN21

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Analyte LN22CD3+ !

CD3+/CD4+ !

CD3+/CD8+ !

Flow Cytometry Calibration Verification/Linearity LN22

Product InformationSurvey LN22 corresponds to the CAP Flow Cytometry Survey FL. Each shipment of LN22 will include seven 1.0-mLliquid whole blood specimens.

Analyte LN23Prostate-Specific Antigen !

Prostate-Specific Antigen Calibration Verification/Linearity LN23


Survey LN23 corresponds to the CAP Ligand Assay Survey K. Each shipment of LN23 will include twelve 1.0-mL liquidserum specimens. The first seven vials will consist of values specified at a range from 0.1-4.0 ng/mL. Vials eightthrough twelve will consist of values specified at a range from 8.0-90.0 ng/mL.

Analyte LN24Creatinine !

Creatinine Accuracy Calibration Verification/Linearity LN24

Product InformationThe LN24 Survey focuses on values for creatinine at the range from 0.5-4.0 mg/dL. Each shipment of LN24 willconsist of six 1.0-mL liquid fresh frozen serum specimens.

Product will ship within two days of the specified ship date.




Analyte LN25Troponin I !

Troponin I Calibration Verification/Linearity LN25


Surveys LN25 corresponds to the CAP Troponins I and T Survey TRP. Each shipment of LN25 will consist of six 2.0-mLliquid serum specimens.

Analyte LN27Troponin T !

Troponin T Calibration Verification/Linearity LN27


Survey LN27 corresponds to the CAP Troponins I and T Survey TRP. Each shipment of LN27 will consist of six2.0-mL liquid serum specimens.



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Analyte LN30BNP !

NT-pro BNP !

B-type Natriuretic Peptides Calibration Verification/LinearityLN30


Survey LN30 corresponds to the CAP B-type Natriuretic Peptides Survey BNP. Each shipment of LN30 will include six1.0-mL liquid plasma specimens for BNP and NT-pro BNP. A seventh 1.0-mL liquid plasma specimen will be includedto test only for NT-pro BNP. Note: Linearity Surveys have linearity targets based on clinical relevance and generalcharacteristics of currently available methods. These criteria may not be reflective of the specific characteris-tics of the currently available single dose unit technology methods. For customers using single dose unit tech-nology, it is the laboratory's discretion to assess the appropriateness of the linearity targets when applied tothis technology and to the clinical needs of their patients.

Analyte LN31Cyclosporine !

Tacrolimus !

Immunosuppressive Drugs Calibration Verification/LinearityLN31


Survey LN31 corresponds to the CAP Immunosuppressive Drugs CS Survey. Each shipment of LN31 will include seven2.0-mL liquid whole blood hemolysate.

Analyte LN32Ammonia !

Ammonia Calibration Verification/Linearity LN32


Each shipment of LN32 will include seven 2.0-mL liquid serum specimens.

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Analyte LN33Myoglobin !

Serum Myoglobin Calibration Verification/Linearity LN33


Survey LN33 corresponds to the CAP Cardiac Markers CARM, CRT, and CRTI Surveys for quantitativemyoglobin. Each shipment of LN33 will include seven 1.0-mL liquid serum specimens.

Analyte LN34CA-125 !

CA-125 Calibration Verification/Linearity LN34

Product InformationLN34 participants may report diluted specimen results. Each shipment of LN34 will include seven 3.0-mL liquidserum specimens.

RRS RRS2Analyte RRS Analyte RRS2Alanine aminotransferase ! B-type Natriuretic Peptides (BNP) !

Albumin ! Pro B-type Natriuretic Peptides (NT-pro BNP) !

Amylase ! Chloride !

Aspartate aminotransferase ! CO2 !

Bilirubin, total ! C-reactive Protein (CRP) !

Calcium ! Folate !

CK-MB ! Gamma Glutamyl Transferase (GGT) !

Creatinine ! Potassium !

Ferritin ! Sodium !

Iron ! Testosterone !

Lactate dehydrogenase ! Thrombin Time (TT) !

Magnesium ! Uric Acid !

Protein, total ! Urea !

T4 (thyroxine) ! Vitamin B-12 !

T4, free (thyroxine, free) !

Total iron binding capacity !

Thyroid stimulating hormone (TSH) !

Reference Range Service RRS, RRS2

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Product InformationThe Reference Range Service (RRS, RRS2, RRS3, RRS4) is designed to assist laboratories to establish and/or verifyreference intervals. Data collection and analysis follows recommendations specified in the Clinical and LaboratoryStandard Insitute (CLSI) document, Defining, Establishing, and Verifying Reference Intervals in the ClinicalLaboratory; Proposed Guideline—Third Edition (C28-P3).

Laboratories will be required to submit 20 results from “normal/healthy” individuals for each analyte withinformation on the sex, age, and race/ethnic background of each donor. Exclusionary criteria will be provided tofacilitate identification of appropriate donors. Submission of donor data will begin in May. All donor results shouldbe returned to the CAP for analysis, including those that may be outside of your laboratory’s established referenceinterval.

Reference intervals from pooled data will be will be provided by platform. Because participants contribute to thedata pool, the CAP cannot guarantee that all platforms will have sufficient donor data to permit the estimation ofreference intervals for every platform/analyte combination. Participants will be notified of platforms with anticipatedreference intervals in February 2008. For analytes without complete platform data, participants will have the optionof submitting donor results and current reference interval information for verification according to the CLSI C28-P3.

Note: The College had determined that Institutional Review Board (IRB) review is not routinely required toparticipate in this reference interval service. However, if the laboratory is in an institution that requiresIRB review to conduct reference interval studies, be advised that the deadline to return donor results tothe CAP will be May.

Analyte RRS3 RRS4Alkaline Phosphatase �

Immunoglobulin A �

Immunoglobulin G �

Immunoglobulin M �

Lipase, serum �

Prostate-specific Antigen (PSA) �

Troponin I �

Hemoglobin �

Hematocrit �

Platelet count �

Red blood cell count �

White blood cell count �

Reference Range Service RRS3, RRS4




Survey ShipmentChallenges A B CSpectrophotometer Linearity (stray light check) ! !

pH Meter check !

Wavelength and Photometric Calibration: !

Acid potassium dichromate solutions—absorbance check, autodilutor check !

Holmium oxide—peak absorbance measurementsThomson’s solutions—wavelength and photometric calibration

Analytical balance check ! !

Fluorescent microscopes — fluorescent intensity check !

Microtiter plate reader linearity ! !

Ocular micrometer calibration !

Osmometer study !

Gravimetric pipette calibration study ! !

Adjustable micropipette calibration verification/linearity ! !

Refractometer calibration ! !

Product InformationSurvey I is designed as an assessment tool for instruments not routinely challenged during the proficiency testingprocess. Linearity results (forward and reverse) for the spectrophotometer and microtiter plate reader are evaluatedby linear regression methods. Appropriate material will be provided to assess important functional parameters,including accuracy and linearity.

Instrumentation I

WARNING: The Instrumentation (I) Survey samples contain substances which may be corrosive, toxic,environmental hazards and irritants.



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Analyte UTCOBenzoylecgonine !

Delta-9-THC-COOH !

Opiates !

Propoxyphene !

Urine Toxicology Carry Over Survey UTCO

Product InformationThe Survey UTCO is designed to help participants evaluate instrument sample probe carry over. Multiple kits may bepurchased. Each shipment of UTCO will consist of a 40.0-mL liquid urine specimen low vial and a 40.0-mL liquidurine high vial. The expiration date of this material is May 31, 2010. A calculation is provided in the kit instruc-tions to assist the participants in determining their instrument sample probe carry over; therefore, data need not bereturned to the CAP.

Analyte SCOCreatinine !

hCG !

Lactate dehydrogenase (LD) !

Phenytoin !

Serum Carry Over Survey SCO

Product InformationThe Survey SCO is designed to help participants prove or disprove instrument sample probe carry over. Multiple kitsmay be purchased. Each shipment of SCO will consist of a 10.0-mL liquid serum specimen low vial and a 5.0-mLliquid serum high vial. The expiration date of this material is May 31, 2010. A calculation is provided in the kitinstructions to assist the participants in determining their instrument sample probe carry over; therefore, data neednot be returned to the CAP.




Bilirubin HemoglobinAnalyte Interferent InterferentAlanine aminotransferase (ALT/SGPT) ! !

Albumin ! !

Alkaline phosphatase (ALP) ! !

Amylase ! !

Aspartate aminotransferase (AST/SGOT) ! !

Bilirubin, total !

Calcium ! !

Chloride ! !

CK2 (MB) ! !

CO2 ! !

Creatine Kinase (CK) ! !

Creatinine ! !

Gamma glutamyl transferase (GGT) ! !

Glucose ! !

Iron ! !

Lactate dehydrogenase (LD) ! !

Lipase ! !

Magnesium ! !

Osmolality ! !

Phosphorus ! !

Potassium ! !

Protein, total ! !

Sodium ! !

Urea ! !

Uric Acid ! !

Interfering Substance Survey IFSProduct InformationSurvey IFS is designed to assistparticipants in verifying manu-facturing interferencespecifications and to investigatediscrepant results caused byinterfering substances such asbilirubin and hemoglobin.Multiple kits may be purchased.

Each shipment of IFS willconsist of twelve 10.0-mL liquidserum specimens. The expira-tion date of this material isJune 30, 2010. Participants willreceive their evaluations oneweek after the results have beenreceived by the CAP.

12HEMATOLOGY AND

CLINICAL MICROSCOPY

Hem

atol

ogy

and

Clin

ical

Mic

rosc

opy

Hematology ......................................................................107

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Product InformationSurveys HE, HEK, and HEP are designed for use with all hematology analyzers. For instruments that provide anautomated differential, refer to Surveys FH1-FH10, FH1K-FH10K, and FH1P-FH10P on page 108. Participants orderingSurveys HE, HEK, or HEP may report two sets of data, but only the first set of results will be used to meet federalregulatory requirements. The first five photomicrographs/color photographs will be evaluated to meet regulatoryrequirements, and the additional five are designed as an educational ungraded component.

The types of cells that participants will be asked to identify in the color photographs and photomicrographs will bemorphological examples of both normal and immature cell lines. If your institution does not identifyabnormal or immature cells, the CAP recommends that you enroll in the XHP module of the EXCEL program. Pleasecontact a CAP Customer Contact Center Representative at 800-323-4040 option 1 for additional information.

Each shipment of Survey HE will contain five whole blood specimens.Each shipment of Survey HEK will contain five whole blood specimens and ten photomicrographs.Each shipment of Survey HEP will contain five whole blood specimens, ten color photographs, and one supplementalCD-ROM containing digital images of the ten blood cell identification challenges.


Product Fulfillment Group HE

Analyte/Procedure HE HEK HEP Challenges per ShipmentBlood cell identificationPhotomicrographs (35mm slide)** ! 10

Color photographs ! 10Supplemental CD-ROM* ! 1 CD with 10 digital images

Hematocrit ! ! ! 5Hemoglobin ! ! ! 5Platelet count ! ! ! 5Red blood cell count ! ! ! 5White blood cell count ! ! ! 5

Basic Hematology HE, HEK, HEP

HematologyAnalytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS).

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*For HEP only the color photographs are to be used for reporting challenges. The CD-ROM has been provided toallow your laboratory to project and view the images in greater detail.

**Beginning in 2010, Survey HEK, Photomicrographs (35mm slide) will no longer be available. Please considerenrolling in Survey HEP, Color Photographs w/ CD-ROM.

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Analyte/Procedure FH1–FH10 FH1K–FH10K FH1P–FH10P Challenges per ShipmentBlood cell identification

Photomicrographs (35mm slide)** ! 10Color photographs ! 10Supplemental CD-ROM* ! 1 CD with

10 digital imagesHematocrit ! ! ! 5Hemoglobin ! ! ! 5Immature granulocyte parameter ! ! ! 5 (FH9 only)Nucleated red blood cell count (nRBC) ! ! ! 5 (FH3 and FH9)Platelet count ! ! ! 5Red blood cell count ! ! ! 5White blood cell count ! ! ! 5WBC differential ! ! ! 5

Product InformationThe FH Hematology Series is designed for use with automated differential hematology analyzers and consists ofinstrument-specific modules. Participants ordering an FH Hematology Series Survey may report two sets of data, butonly the first set of results will be used to meet federal regulatory requirements. The first five photomicrographs/color photographs will be evaluated to meet regulatory requirements, and the additional five are designed as aneducational ungraded component. Note: To receive 35mm photomicrographs for blood cell identification, pleaseorder the appropriate instrument-specific module FH1K-FH10K. To receive color photographs for blood cellidentification, please order the appropriate instrument-specific module FH1P-FH10P.

The types of cells that participants will be asked to identify in the color photographs and photomicrographs will bemorphological examples of both normal and immature cell lines. If your institution does not identifyabnormal or immature cells, the College recommends that you enroll in the XHP module of the EXCEL program.Please contact a CAP Customer Contact Center Representative at 800-323-4040 option 1 for additionalinformation.

Each shipment of Surveys FH1-FH10 will contain five whole blood specimens with pierceable caps.Each shipment of Surveys FH1K-FH10K will contain five whole blood specimens with pierceable caps and tenphotomicrographs.Each shipment of Surveys FH1P-FH10P will contain five whole blood specimens with pierceable caps, ten colorphotographs, and one supplemental CD-ROM containing digital images of the ten blood cell identification challenges.


For your shipping and analysis convenience, the instrument-specific modules are contained in their own unique ProductFulfillment Group.

Hematology Automated Differentials FH Series

*For FH1P-FH10P only the color photographs are to be used for reporting challenges. The CD-ROM has beenprovided to allow your laboratory to project and view the images in greater detail.

**Beginning in 2010, Surveys FH1K-FH10K, Photomicrographs (35mm slide) will no longer be available.Please consider enrolling in Surveys FH1P-FH10P, Color Photographs w/ CD-ROM.

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Instrument FH1, FH2, FH3, FH4, FH6, FH8, FH9, FH10,FH1K, FH2K, FH3K, FH4K, FH6K, FH8K, FH9K, FH10K,FH1P FH2P FH3P FH4P FH6P FH8P FH9P FH10P

Horiba ABX 9000+, 9018+, 9020+, !

Sysmex K-series, KCP-1, KX-21/21N, poc H-100i !

Abbott Cell-Dyn 1200, 1600, 1700, 1800 !

Horiba ABX Micros !

Siemens ADVIA 60 !

Coulter AcT, MD, Onyx, ST, STKR, T-series !

Danam DC-18, I-1800, EXCELL 10/16/18 !

Abbott Cell-Dyn 3000, 3200, 3500, 3700, 4000,Sapphire, Ruby !

Siemens ADVIA 70 !

Danam EXCELL 22 !

Siemens ADVIA 120, 2120 !

Coulter Gen-S, HmX, LH500, LH700 series,MaxM, STKS, VCS !

Sysmex SE-9000, 9500, 9500R, SF-3000 !

Sysmex XE-2100, XE-2100D, XE-2100L, XE-5000,XT-1800i, XT-2000i, XS-800i, XS-1000i, XS-1000iAL !

ABX Pentra 60, 80, 120 !

Coulter AcT 5 diff !

Pierceable caps ! ! ! ! ! ! ! !

Hematology Automated Differentials, continued

The CAP Surveys Hematology, Clinical Microscopy, and Body FluidsGlossaryThe CAP Surveys Hematology, Clinical Microscopy, and Body Fluids Glossary “provides a wealth of information” for everyhematology laboratory to help assure accurate patient results. This outstanding resource is available online at www.cap.org,and provides practical definitions for:

• Blood identification • Nasal smears for eosinophils • Urine sediment• Skin and hair KOH preparations • Body fluids • Stool examinations• Vaginal wet preparations • Pinworm preparations • Fecal leukocytes• Arthropods

This resource is comprehensive, concise, organized for ease of use, and available online for immediate reference.

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Analyte/Procedure BCK BCP Challenges per ShipmentBlood cell identification

Photomicrographs (35mm slides)** ! 10Color photographs ! 10Supplemental CD-ROM* ! 1 CD with 10 digital images

Product InformationFor additional sets of photomicrographs (35mm slides) or to purchase only photomicrographs without liquidhematology specimens, please order Survey BCK (photomicrographs). For additional sets of color photographs or topurchase only color photographs without liquid hematology specimens, please order Survey BCP (colorphotographs). Each shipment of Survey BCK contains ten photomicrographs. Each shipment of Survey BCP containsten color photographs and one supplemental CD-ROM containing digital images of the ten blood cell identificationchanges.

The types of cells that participants will be asked to identify in the color photographs (BCP) and photomicrographs(BCK) will be morphological examples of both normal and immature cell lines. If your institution does not identifyabnormal or immature cells, the College recommends that you enroll in the XHP module of the EXCEL program.Please contact a CAP Customer Contact Center Representative at 800-323-4040 option 1 for additional information.


Product Fulfillment Group KP

Blood Cell Identification BCK, BCP

Instrument/Method RT* RT2 RT3 RT4 Challenges per ShipmentAbbott Cell-Dyn 3200, 3500, 3700, Ruby ! 3All other manual & automated methods ! 3Coulter STKS, MaxM, GenS, HmX,LH500, LH700 series ! 3Sysmex XE-2100, XE-5000, and XT2000i ! 3Pierceable caps ! 3

Product InformationEach shipment will include three 1.0-mL liquid stabilized red blood cell specimens.

Reticulocyte RT, RT2, RT3, RT4

*For BCP only the color photographs are to be used for reporting challenges. The CD-ROM has been provided to allow yourlaboratory to project and view the images in greater detail.**Beginning in 2010, Survey BCK, Photomicrographs (35mm slide) will no longer be available. Please consider

enrolling in Survey BCP, Color Photographs w/CD-ROM

*Survey RT is designed for all other manual and automated methods NOT listed above

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Product InformationSurvey ESR is designed for all automated and manual erythrocyte sedimentation rate methods, except for theSedimat® 15. Survey ESR1 is designed for the Sedimat® 15. Each shipment will include three 6.0-mL whole bloodspecimens.

Procedure ESR ESR1 Challenges per ShipmentAll methods except the Sedimat® 15 ! 3Sedimat® 15 ! 3

Erythrocyte Sedimentation Rate ESR, ESR1

Procedure TRC Challenges per ShipmentPlatelet count (Platelet-Rich Plasma) ! 5WBC count (Leukocyte-Reduced Platelet Suspension) ! 2WBC count (Leukocyte-Reduced Red Blood Cell Suspension) ! 2

Transfusion-Related Cell Count TRC

Product InformationSurvey TRC provides hematology and/or transfusion medicine laboratories with proficiency testing material forvarious cell count procedures. The Platelet-Rich Plasma material can be utilized for both manual and automatedplatelet count methods. The Leukocyte-Reduced Red Blood Cell suspensions and Leukocyte-Reduced Plateletsuspensions provide laboratories with an opportunity to assess their ability to perform low white blood cell (WBC)counts. Note: The Leukocyte-Reduced Red Blood Cell and Leukocyte-Reduced Platelet materialsmust be used with a Nageotte chamber or flow cytometry.

Each shipment will include five 1.5-mL suspensions of stabilized mammalian platelets (Platelet-Rich Plasma),two 1.0-mL vials containing a leukocyte-reduced red blood cell material, and two 1.0-mL vials containing aleukocyte-reduced platelet material.

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Procedure SCS Challenges per ShipmentSickling test ! 3

Procedure HCC Challenges per ShipmentHemoglobin ! 2Glucose ! 2

Procedure HG Challenges per ShipmentAbnormal hemoglobin(s) identification ! 4“Dry lab” educational challenges ! 1Hemoglobin A2 quantitation ! 4Hemoglobin F quantitation ! 1Sickling test ! 4

Hemoglobinopathy HG

Product InformationSurvey HG is designed for laboratories performing comprehensive and extensive hemoglobinopathy identificationprocedures. Laboratories performing only sickling tests should consider Survey SCS above. Each shipment willcontain four 0.5-mL stabilized red blood cell specimens. In addition, one “dry lab” challenge (electrophoresispattern diagrams) will be provided.

Sickle Cell Screening SCS

Product InformationEach shipment will contain three 0.6-mL stabilized human erythrocyte specimens.

Waived Combination HCC

Product InformationSurvey HCC is designed for participants using the HemoCue® and Stanbio HemoPoint® H2 instruments. Each shipmentwill include two 1.0 mL whole blood specimens.

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Analyte APT Challenges per ShipmentFetal hemoglobin ! 2

Analyte AFL Challenges per ShipmentpH interpretation ! 2

Analyte/Procedure HBF Challenges per ShipmentFetal RBCs, qualitative (Rosette fetal screen) ! 2Fetal RBCs, quantitative (Kleihauer-Batke, Flow Cytometry) ! 2

Fetal Red Cell Determination HBF

Product InformationSurvey HBF is designed for the detection of fetal red blood cells in maternal blood using qualitative (Rosette) and/orquantitative (Kleihauer-Betke or flow cytometry) methods. Each shipment will include two 1.2-mL liquid stabilizedred blood cell specimens. HBF is not designed for F cell quantitation.

For competency assessment of technologists’ ability to perform fetal red blood cell quantitation, refer to SurveyTMCAF – Transfusion Medicine Competency Assessment – Fetal Red Blood Cell Quantitation in Chapter 17.

Fetal Hemoglobin APT

Product InformationEach shipment of Survey APT will include two vials of simulated gastric fluid.

Amniotic Fluid Leakage (Nitrazine) AFL

Product InformationSurvey AFL is designed for laboratories performing pH using Nitrazine paper and is compatible with Amniotest™.Each shipment will contain two 2.0-mL liquid specimens.

Analyte ROM Challenges per ShipmentPlacental Alpha Microglobulin-1 (PAMG-1) ! 2

Rupture of Fetal Membranes Testing ROM

Product InformationEach shipment of Survey ROM will contain two simulated vaginal specimens for assessment of rupture of fetalmembranes.

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Procedure G6PDS Challenges per ShipmentG6PD ! 2

Procedure V Challenges per ShipmentViscosity ! 2

Viscosity V


Glucose-6-phosphate Dehydrogenase G6PDS

Product InformationEach shipment includes two lyophilized hemolysate samples for the quantitative and qualitative determination ofglucose-6-phosphate dehydrogenase.

Procedure BP Challenges per ShipmentThin/Thick* blood film sets, Giemsa-stained ! 5

Product InformationSurvey BP meets regulatory requirements for laboratories performing only blood parasite testing. Survey BP willconsist of five thin blood films and corresponding thick films (*when available) and/ or color photographchallenges per shipment. The samples will include a variety of blood parasites, including Plasmodium, Babesia,Trypanosoma, and a variety of filarial worms. Thick film examination is the gold standard for detection of bloodparasites, and this Survey will allow participants to periodically compare the thick and thin film appearance of avariety of blood parasites.

Blood Parasite BP

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Analyte/Procedure CM CMP Challenges per ShipmentBilirubin ! ! 3Glucose ! ! 3hCG (qualitative) ! ! 3Blood or hemoglobin ! ! 3Ketones ! ! 3Leukocyte esterase ! ! 3Nitrite ! ! 3Osmolality ! ! 3pH ! ! 3Protein (qualitative) ! ! 3Reducing substances ! ! 3Specific gravity ! ! 3Urobilinogen ! ! 3Urine sediment photomicrographs (35mm slide)** ! 4Body fluid photomicrographs (35mm slide)** ! 6Urine sediment color photographs ! 4Body fluid color photographs ! 6Supplemental CD-ROM* ! 1 CD with 10 images

Clinical Microscopy

Clinical Microscopy CM, CMP

Product InformationSurvey CM is designed for laboratories that perform routine urinalysis and body fluid testing. Each shipment of SurveyCM will include three 10.0-mL liquid urine specimens, four urine sediment photomicrographs, and six body fluidphotomicrographs.

Survey CMP will include three 10.0 mL liquid urine specimens, four urine sediment color photographs, six body fluidcolor photographs, and a supplemental CD-ROM containing digital images.


Product Fulfillment Group CM


*For CMP only the color photographs are to be used for reporting challenges. The supplemental CD-ROM has beenprovided to allow your laboratory to project and view the images in greater detail.

**Beginning in 2010, Survey CM, Photomicrographs (35mm slide) will no longer be available. Please considerenrolling in Survey CMP, Color Photographs w/CD-ROM.

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Analyte/Procedure UMC Challenges per ShipmentUrine albumin, semi-quantitative ! 2Creatinine ! 2Albumin: Creatinine ratio ! 2

Product InformationSurvey UMC is designed for dipstick or semi-quantitative methods. It is not appropriate for quantitative methods. Forquantitiative reporting, refer to Survey U, page 58.

Urine Albumin/Creatinine UMC

Challenges per ShipmentAnalyte UAA UAA1RBC, quantitative 2 2WBC, quantitative 2 2Crystals, semi-quantitative 2Epithelial cells, semi-quantitative 2Bacteria, semi-quantitative 2 2Casts, semi-quantitative 2 2

Product InformationSurvey UAA is designed for participants using Iris instruments. Survey UAA1 is designed for participants using theSysmex series instruments. Each shipment will include two liquid urine samples.

Automated Urinalysis UAA, UAA1

Analyte/Procedure DSC Challenges per ShipmentBilirubin ! 2Sulfosalicylic acid (SSA) ! 2

Dipstick Confirmatory Testing DSC

Product InformationSurvey DSC is designed for laboratories performing confirmatory testing for bilirubin and protein urine dipstickresults. Each shipment will include two 12.0-mL liquid urine specimens.




www.cap.org

Specimen Type CMM CMMP Challenges per ShipmentFern Test ! ! 1KOH Preparations ! ! 1Nasal Smears ! ! 1Pinworm Preps ! ! 1Stool for Leukocytes ! ! 1Vaginal Wet Preparations ! ! 1Photomicrographs (35mm slide)** ! Total of 6Color Photographs ! Total of 6Supplemental CD-ROM* ! 1 containing 6 images

Product InformationSurveys CMM and CMMP are designed for laboratories performing provider-performed microscopy and will includeimages from the specimen types listed above. Each shipment of Survey CMM will include six photomicrographs. Eachshipment of Survey CMMP will include six color photographs and a supplemental CD-ROM containing images.


Clinical Microscopy Miscellaneous CMM, CMMP

Procedure BFC URC Challenges per ShipmentBody Fluid Crystals ! 2Red Blood Cells ! 2White Blood Cells ! 2Urine Crystals ! 2

Crystals BFC, URC

Product InformationEach shipment of BFC will include two simulated body fluid specimens for identification of red blood cells, whiteblood cells, and crystals found in body fluid specimens (eg, synovial fluid).

Each shipment of URC will include two urine specimens for identification of crystals found in urine.

Product Fulfillment Group CRS

*For CMMP only the color photographs are to be used for reporting challenges. The CD-ROM has beenprovided to allow your laboratory to project and view the images in greater detail.

**Beginning in 2010, Survey CMM, Photomicrographs (35mm slide) will no longer be available. Pleaseconsider enrolling in Survey CMMP, Color Photographs w/CD-ROM




Analyte OCB Challenges per ShipmentOccult blood ! 3

Occult Blood OCB

Product InformationEach shipment will include three vials of a simulated fecal material.


Product InformationEach shipment of Survey SCM1 will include a color photograph with two images for evaluation of the presence orabsence of urine hemosiderin. Each shipment of SCM2 will include a color photograph with two images for theevaluation of the presence or absence of urine eosinophils.

Product Fulfillment Group SCM

Procedure SCM1 SCM2 Challenges per ShipmentUrine Hemosiderin, Prussian blue ! 2Urine Eosinophils, Wright stain ! 2

Special Clinical Microscopy SCM1, SCM2

Analyte FCFS Challenges per ShipmentFecal fat ! 2

Product InformationEach shipment includes two simulated fecal fat samples for qualitative testing.

Qualitative testing is intended for microscopic analysis and determination of neutral and/or split fats.

Fecal Fat FCFS



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Procedure HFC Challenges per ShipmentRed blood cell count ! 3White blood cell count ! 3Cytopreparation differential ! 3

Hemocytometer Fluid Count HFC

Product InformationSurvey HFC is designed to assess accuracy when performing manual cell counts on body fluids or cerebrospinal fluid.Each shipment will include three vials of a simulated body fluid material. Red blood cells and white blood cells canbe readily identified and counted using a hemocytometer. Cell counts will be comparable to those of body fluids andcerebrospinal fluid. The material can also be used for cytopreparation differentials.

Product InformationEach shipment will include three vials of a simulated gastric material.


Analyte GOCB Challenges per ShipmentGastric occult blood ! 3Gastric pH ! 3

Gastric Occult Blood GOCB




Analyte ABF1 ABF2 ABF3 Challenges per ShipmentRed blood cell count ! ! ! 2White blood cell count ! ! ! 2

Automated Body Fluid – ABF Series

Product InformationEach shipment of Survey ABF1, ABF2, and ABF3 will include two vials of simulated body fluid.

Instrument ABF1 ABF2 ABF3Siemens ADVIA 120/2120 !

Beckman Coulter LH 700 Series !

Sysmex XE 2100, XT-1800i, XT-2000i !

Iris iQ 200 !

Iris Diagnostics 500 !

Automated Body Fluid, Method Matrix

13REPRODUCTIVE MEDICINE

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Embryology ......................................................................122

Reproductive Endocrinology ................................................122

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Procedure SC SC1 SM SV ASA Challenges per ShipmentSperm count & presence/absence*(all manual methods and CASA systems) ! 2Sperm count & presence/absence*(Automated Methods) ! 2Sperm morphology ! 2Sperm viability ! 2Antisperm antibody IgG ! 2

Product InformationProcedures can be combined to meet your laboratory’s individual testing requirements.

Survey SC is designed for laboratories that report qualitative and quantitative sperm counts. Each challenge willinclude two 0.3 mL stabilized human sperm specimens.

Survey SC1 is specifically designed for laboratories using automated sperm count methods. Each challenge willinclude two 1.0 mL stabilized human sperm specimens.

Each shipment of Survey SM will include two prepared slides for staining.Each shipment of Survey SV will include two eosin-negrosin-stained slides.Each shipment of Survey ASA will include two serum specimens.


Product Fulfillment Group SEM

Semen Analysis SC, SC1, SM, SV, ASA

*The SC Survey is appropriate for participants that test post-vasectomy specimens.

Product InformationEach shipment of SMCD will include a CD with video clips for sperm motility and sperm count.Each shipment of SM1CD will include a CD with images for sperm morphology analysis.

Product Fulfillment Group SPCD

Procedure SMCD SM1CD Challenges per ShipmentSperm count ! 2Sperm motility ! 2Sperm morphology ! 2

Sperm Motility & Morphology SMCD, SM1CD

Reproductive Medicine - Andrology and EmbryologyAnalytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS).

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Analyte EMB Challenges per ShipmentEmbryo Transfer � 4

Embryology EMB

Product InformationEach shipment of Survey EMB will include a CD with video clips of embryos, three and five days post-fertilization.

Product InformationSurvey DY allows participants to report testosterone (free), testosterone (bioavailable), and sex hormone-bindingglobulin with Survey Y or YY. Survey DY must be purchased in conjunction with Survey Y or YY. Each shipment ofSurvey Y will include six 5.0-mL liquid serum specimens, consisting of two duplicate sets. Each shipment of SurveyYY will include nine 5.0-mL liquid serum specimens, consisting of three duplicate sets.

Each set of YVM ordered will consist of six 5.0-mL liquid serum specimens, consisting of two duplicate sets.


Module DY (data processing for testosterone [free and bioavailable] and sex hormone-binding globulin [SHBG] reporting)YY(additional vials of Surveys Y)

LIGAND ASSAY (SPECIAL) VALIDATED MATERIAL (YVM)

Procedure Y DY Challenges per Shipment11-Deoxycortisol � 317-Hydroxyprogesterone � 3Androstenedione � 3DHEA sulfate � 3Estradiol � 3Estriol, unconjugated (uE3) � 3Follicle-stimulating hormone (FSH) � 3Growth hormone � 3IGF-1 (Somatomedin C) � 3Luteinizing hormone (LH) � 3Progesterone � 3Prolactin � 3Testosterone � 3Testosterone, bioavailable � 3Testosterone, free � 3Sex hormone-binding globulin (SHBG) � 3

Ligand Assay (Special) Y (YY), DY

14COAGULATION

New for 2009! Heparin Induced Thrombocytopenia (CGS5)

Quality Management in Clinical Laboratories: Promoting PatientSafety Through Risk Reduction and Continuous ImprovementPaul Valenstein, MD, FCAP, editor

Quality Management in Clinical Laboratories: Promoting PatientSafety Through Risk Reduction and Continuous Improvement is apractical “how-to” manual written for the laboratory director,supervisor, and practicing pathologist. Sponsored by the Collegeof American Pathologists Quality Practices Committee and PatientSafety and Performance Measures Committee, the manual isdesigned to help readers manage quality and patient safety inclinical laboratories; comply with quality and patient safetyregulations and accreditation requirements; and develop andadminister a quality management plan.

Quality Management in Clinical Laboratories covers the most important standardsand areas that have proven to be particularly problematic in the management ofclinical laboratories. Patient safety issues—an essential and inseparable componentof laboratory quality—are discussed throughout the text.

Contents include:

! Case studies based on knowledge of actual events

! Approaches to managing quality and patient safety

! Regulation and accreditation

! Specific quality and patient safety risks and control measures for preanalytic,analytic, postanalytic, and general laboratory operations

! The laboratory quality management plan, with sample plans

! Extensive glossary and up-to-date references

For more information, please visit our Web site at www.cap.org where you will find detailsunder the Publications tab or call 800-323-4040 option 1.

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Coagulation Limited Validated Material (CGM)

Analyte CGL CGDF Challenges per ShipmentActivated partial thromboplastin time ! 5Fibrinogen ! 5International Normalized Ratio (INR) ! 5Prothrombin time ! 5D-dimer ! ! 2 per yearFibrin(ogen) degradation products, plasma ! ! 2 per yearFibrin(ogen) degradation products, serum ! ! 2 per year

Product InformationEach shipment includes:! Survey CGL will contain six 1.0-mL lyophilized plasma specimens and one 1.0-mL serum specimen for FDP

analysis.! Survey CGDF will contain one 1.0-mL lyophilized plasma specimen and one 1.0-mL serum specimen for FDP

analysis.! Survey CGM will contain six 1.0-mL lyophilized plasma specimens and one 1.0-mL serum specimen for FDP

analysis.An education activity is planned that includes reading material found in the Participant Summary and onlinelearning assessment questions. All laboratory staff can participate individually and earn free CE credit withoutleaving the laboratory.

Product Fulfillment Group CGL

Coagulation Limited CGL, CGDF

CoagulationAnalytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Serviced (CMS).

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Analyte CGE CGEX Challenges per ShipmentSee below* ! ! 2

Coagulation Extended CGE, CGEX

Product InformationSurveys CGE/CGEX are designed to provide participating laboratories with plasma challenges to meet regulatoryrequirements for factor assays and other related coagulation assays, including, but not limited to:

Survey CGE will contain three 1.0-mL lyophilized plasma specimens.

Survey CGEX will contain five 1.0-mL lyophilized plasma specimens.

A four-week turnaround time is allowed for submitting results.

• 50:50 Mixing Study, PT and APTT

• Activated Protein C Resistance

• Alpha-2–Antiplasmin

• Anti-beta-2–Glycoprotein

• Antiphospholipid Antibody

• Antithrombin III

• Collagen Binding

• Dilute Prothrombin Time

• Dilute Russell’s Viper VenomTime

• Euglobulin Test

• Factors II, V, VII, VIII, IX, X, XI,XII, and XIII

• Factor VIII Inhibitor

• Fibrin Monomer

• Fibrinogen Antigen

• Glycoprotein I Binding

• High Molecular Weight Kininogen

• Kaolin-Activated APTT

• Kaolin Activated Clotting Time

• Lupus Anticoagulant

• Plasminogen Antigen

• Plasminogen Activator Inhibitor

• Prekallikrein

• Protein C

• Protein S

• Prothrombin Fragment 1.2

• Reptilase Time

• Ristocetin Cofactor

• Thrombin – Antithrombin

• Thrombin Time

• Tissue Plasminogen Activator

• von Willebrand FactorActivity/Multimer Analysis

• von Willebrand Factor Antigen

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Module/Analyte CGS1* CGS2 CGS3* CGS4* CGS5 Challenges per ShipmentActivated Partial Thromboplastin Time ! ! ! 2/3 (CGS4)International Normalized Ratio (INR) ! ! 2/3 (CGS4)Prothrombin Time ! ! 2/3 (CGS4)Lupus Anticoagulant Module

Lupus Anticoagulant (Confirmation and Screen) ! 2International Normalized Ratio (INR) ! 2Mixing Studies, APTT ! 2Thrombophilia ModuleActivated Protein C Resistance ! 2Antithrombin (Activity, Antigen) ! 2Protein C (Activity, Antigen) ! 2Protein S (Activity, Free Antigen, Total Antigen) ! 2

von Willebrand Factor Antigen ModuleFactor VIII, Activity ! 2von Willebrand Factor (Antigen, Activity,Multimers) ! 2Heparin ModuleHeparin Activity (Unfractionated and LowMolecular Weight) ! 3Thrombin Time ! 3Heparin Induced Thrombocytopenia Module ! 2

**PF4 Enchanced® assay ! 2

Coagulation Special Testing CGS Series

Product InformationThe CGS series is designed for laboratories that perform special panel coagulation testing for the diagnosis ofcoagulation disorders as well as heparin assays.

*APTT, INR and PT challenges in these Surveys are not appropriate for meeting regulatory requirements, pleaserefer to Survey CGL (page 123).

**Product CGS5 is only appropriate for use with the GTI Diagnostics PF4 Enhanced® assay.

New

126 Coagulation



Product InformationSurvey WP8 is designed for laboratories performing waived PT testing on the CoaguChek® and CoaguChek S.

Analyte WP8 Challenges per ShipmentProthrombin time ! 3International Normalized Ratio (INR) ! 3

Whole Blood Prothrombin Time/INR – CoaguChek Waived WP8

Analyte WP4 WP6 WP7 WP9 Challenges per ShipmentProthrombin time ! ! ! ! 5International Normalized Ratio (INR) ! ! ! ! 5Activated partial thromboplastin time 5

Product InformationSurvey WP4 is compatible with the Hemochron/IL GEM® (citrated), Jr. Signature/Signature+, Signature Elite, and Jr. IISurvey WP6 is compatible with the Hemochron/IL GEM® (non-citrated).Survey WP7 is compatible with the CoaguChek® (CoaguChek S).Survey WP9 is compatible with the Roche CoaguChek® XS Plus.

Whole Blood Coagulation WP4, WP6, WP7, WP9

Product InformationSurvey WP3 is compatible with the i-STAT PT/INR instrument. Each shipment will contain five lyophilized plasmaspecimens.

Analyte WP3 Challenges per ShipmentProthrombin time ! 5International Normalized Ratio (INR) ! 5

Whole Blood Prothrombin Time WP3

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Product InformationSurvey PF will contain four 3.2% sodium citrate vacuum tubes, two 10.0-mL plastic tubes, and two vials ofspecified agonists. Survey PF/PF1 allows for single instrument/method reporting only. For second instrument/methodreporting, the purchase of an additional kit is required.

The PF1 Survey will contain two 3.2% sodium citrate vacuum tubes and two 10 x 75 plastic tubes.

Product Fulfillment Group PF

Method PF PF1 Challenges per ShipmentPlatelet Aggregation ! 2PFA-100 ! 2Plateletworks ! 2

Platelet Function PF, PF1

Product InformationSurvey WBDD is compatible with whole blood qualitative D-dimer methods, such as the SimpliRED™ D-dimer and theClearview Simplify D-dimer. Each shipment will contain two specimens.

Analyte WBDD Challenges per ShipmentD-dimer ! 2

Whole Blood D-dimer WBDD

Note: For Surveys PF and PF1, a normal donor sample is collected and tested for platelet functionaccording to your laboratory procedure.

Product InformationEach shipment will include two specimens and all materials to complete two challenges.

Instrument/Method TEG Challenges per ShipmentThromboelastogram ! 2

Thromboelastogram TEG

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Instrument/Cartridge CT CT1 CT2 CT3 Challenges per ShipmentHelena Actalyke ! 3IL GEM® PCL ACT ! 3IL GEM® PCL ACT-LR ! 3ITC HEMOCHRON CA 510/FTCA510 ! 3ITC HEMOCHRON P214/P215 ! 3ITC HEMOCHRON FTK-ACT ! 3ITC HEMOCHRON® Jr. ACT+ ! 3ITC HEMOCHRON® Jr. ACT-LR ! 3Medtronic HemoTec ACT/ACT II/ACT Plus HR ACT ! 3Medtronic HemoTec ACT/ACT II/ACT Plus LR ACT ! 3Medtronic HemoTec Hepcon HMS, HMS Plus ! 3Medtronic HemoTec ACT/ACT II/ACT Plus R ACT ! 3Sienco Sonoclot ! 3CVDI TAS HMT/Bayer ! 3i-STAT Celite and Kaolin ACT* ! 3

Product InformationThe Activated Clotting Time CT Survey Series has been created to meet the specific needs of a variety of coagulationinstruments currently on the market. Select the compatible module for your instrument and cartridge from the chartabove. For Surveys CT, CT1, CT2, and CT3, each shipment will contain three whole blood specimens withcorresponding diluent vials.

Activated Clotting Time Series CT, CT1, CT2, CT3

* i-STAT users will need 0.025M CaCl2 (Trinity Biotech #50355 or equivalent) available for testing since CaCl2 is notprovided in the CT1 kit.

15MICROBIOLOGY

New for 2009! Nucleic Acid Amplification, Organisms (IDO)

! Nucleic Acid Amplification, Viruses (ID1, ID1T)

! Nucleic Acid Amplification, Respiratory (ID2)

! Methicillin Resistant Staphylococcus aureus (MRS5)

! Stool Pathogen (SP, SP1)

Bacteriology ......................................................................129

Mycobacteriology ..............................................................137

Mycology..........................................................................138

Parasitology ......................................................................140

Virology............................................................................142

Molecular Microbiology......................................................147

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Procedure D D4 D2 D7 D3 D1Bacterial Identification ! ! ! ! ! !Gram Stain ! ! ! ! !Antimicrobial susceptibility testing ! ! ! !Bacterial Antigen detection ! !

Guide for Ordering the Appropriate Bacteriology Survey

BacteriologyAnalytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS).

Product InformationThe table above is provided as a guide for ordering the appropriate Bacteriology Surveys for your laboratory’s testingmenu. See the following pages for a more detailed description of each Survey. In order to meet CLIA requirementsfor the subspecialty of bacteriology, five specimens must be reported for each mailing. If you have any questions,please contact the CAP Customer Contact Center at 800-323-4040 option 1.

130 Bacteriology



Handle with CareSpecimens included in the Bacteriology Surveys may contain pathogens and must be handledwith extreme care. These specimens must be dealt with and disposed of only by trainedlaboratory personnel.

Product InformationSurvey D is designed for laboratories performing extensive microbiology procedures (bacterial identification ofaerobes and anaerobes by conventional or molecular methods, isolation from multiple sites, antimicrobialsusceptibility testing, Gram stain, and antigen detection). Laboratories offering a more limited range of testing shouldconsider enrolling in Bacteriology (Limited) Survey D4 or individual Surveys D1, D2, D3, D5, D6, D7, D8, and D9.

Each shipment will include five specimens, in duplicate, and two specimens for antigen detection. Antigen detectionchallenges will be offered in the following shipments:

• A - Clostridium difficile toxin/antigen and Spinal Fluid Meningitis Panel• B - Clostridium difficile toxin/antigen and Group A Streptococcus• C - Group A Streptococcus and Spinal Fluid Meningitis Panel

An education activity is planned that includes reading material found in the Final Critique and online learning assess-ment questions. All laboratory staff can participate individually and earn free CE credit without leaving the laboratory.

Procedure D Challenges per ShipmentAntimicrobial susceptibility testing ! 1-graded, 1-ungradedBacterial antigen detection ! 2Bacterial identification ! 5Gram stain ! 1

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Procedure BCS Challenges per ShipmentBlood culture bacterial detection ! 2

Product InformationSurvey BCS is designed for laboratories performing microbiology procedures for the detection of organisms in bloodcultures. Each shipment will contain two challenges for inoculation of blood culture bottles.Note: Since 5 specimens must be reported for each mailing for the subspecialty of bacteriology, participation inthis Survey only will not meet CLIA regulatory requirements.

Blood Culture BCS

Procedure D1 D2 D3 D7 Challenges per ShipmentAntimicrobialsusceptibility testing ! ! 1Bacterial identification ! ! ! ! 5Gram stain ! ! ! 1Culture source: Throat Urine Various sources Throat/urineMicrobiologic level: Presence or Pathogens Presence or Combination

absence of and/or absence of of two throatGroup A contaminants Neisseria and three

Streptococcus identified to the gonorrhoeae urine culturedetermination extent of your determination specimens

laboratory’sprotocol

Throat, Urine, GC Cultures D1, D2, D3, D7

Product InformationSurveys D1, D2, D3, and D7 are designed for the laboratory performing a limited menu of microbiology procedures.Each shipment of Surveys D1, D2, D3, and D7 will contain five specimens in duplicate. Survey D7 will contain twothroat and three urine culture specimens.

132 Bacteriology



Procedure D4 Challenges per ShipmentAntimicrobial susceptibility testing ! 1Bacterial antigen detection ! 1Bacterial identification ! 5Gram stain ! 1Culture types: Microbiologic level:

Throat culture Presence or absence of Group AStreptococcus determined

Urine culture Pathogens and/or contaminantsidentified to the extent

of your laboratory’s protocolGC culture Presence or absence of

Neisseria gonorrhoeae determined

Bacteriology (Limited) D4

Product InformationSurvey D4 is designed for the laboratory performing moderately comprehensive microbiology procedures. Eachshipment of Survey D4 will contain five inoculated loop specimens, in duplicate, and one swab specimen forGroup A Streptococcus antigen detection.

Procedure D5 Challenges per ShipmentGram stain ! 5

Product InformationEach shipment will contain five air-dried, methanol-fixed, unstained glass slides.

Gram Stain D5

Procedure D6 Challenges per ShipmentGroup A Streptococcus antigen detection ! 5

Product InformationEach shipment will contain five swab specimens.

Rapid Strep Antigen Detection D6

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Procedure D8 Challenges per ShipmentGroup B Streptococcus detection ! 5

Product InformationEach shipment will contain five swab specimens. Survey D8 is compatible with antigen and molecular methods.

Group B Strep Detection D8

Analyte ST Challenges per ShipmentShiga toxin ! 2

Product InformationEach shipment will include two liquid simulated stool specimens for direct shiga toxin testing.

Shiga Toxin ST

Procedure MRS Challenges per ShipmentMRSA detection ! 2

Product InformationSurvey MRS is designed for laboratories performing screening testing for the detection of Methicillin ResistantStaphylococcus aureus. Each shipment will contain two swab specimens. Survey MRS is compatible with molecularand culture based testing.

Methicillin Resistant Staphylococcus aureus Screen MRS

Procedure MRS5 Challenges per ShipmentMRSA detection ! 5

Product InformationSurvey MRSA is designed for laboratories performing screening testing for the detection of Methicillin ResistantStaphylococcus aureus from a swab. Survey MRS5 is compatible with moleccular and culture based testing.Participation in this Survey will meet CLIA requirements.

Methicillin Resistant Staphylococcus aureus Screen MRS5 New

134 Bacteriology



Procedure D9 Challenges per ShipmentGroup A Streptococcus antigen detection � 2

Product InformationSurvey D9 is designed for laboratories performing testing for the detection of Group A Streptococcus antigen using awaived method. Each shipment will include two swab specimens.

Rapid Strep A Antigen Detection, Waived D9

Challenges per ShipmentAnalyte BAS A BLegionella – bronchoalveolar lavage � 1Bordetella pertussis/parapertussis – nasal wash � 1 1Streptococcus pneumoniae – urine � 1

Product InformationSurvey BAS shipments will include lyophilized, liquid, or simulated clinical specimens for bacterial antigen detectionby the methods commonly used for testing (eg, direct fluorescent antibody [DFA], enzyme immunoassay [EIA], latexagglutination, optical immunoassay [OIA]).

Analyte LAS Challenges per ShipmentLegionella pneumophila � 2

Product InformationEach shipment will include two 0.5-mL liquid urine specimens to be used for detection of Legionella pneumophilaantigen by enzyme immunoassay (EIA) or immuno-chromatographic methods.

Legionella Antigen Detection (Urine) LAS

Bacterial Antigen Detection BAS

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Analyte VS VS1 Challenges per ShipmentGardnerella vaginalis ! 5Candida sp. ! 5Trichomonas vaginalis ! ! 5

Product InformationEach shipment will include five swabs to be used for identification by DNA probe technology.Survey VS is intended for testing using the BD Affirm VP III antigen detection method.Survey VS1 is intended for testing using the Genzyme OSOM Trichomonas Rapid Test method.

Product Fulfillment Group VS

Vaginitis Screen Antigen Detection VS, VS1

Procedure HPS Challenges per ShipmentHelicobacter pylori antigen detection ! 2

Product InformationSurvey HPS is designed for laboratories performing enzyme immunoassay (EIA) testing for Helicobacter pyloriantigen in stool. Each shipment will include two 0.5-mL fecal suspensions.

Helicobacter pylori Antigen, stool HPS

Analyte RUR Challenges per ShipmentUrease ! 2

Rapid Urease RUR

Product InformationEach shipment of Survey RUR will include two simulated gastric biopsy specimens. Survey RUR is compatible withmethods such as CLOTEST®.

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Analyte/Procedure LPX Challenges per ShipmentLive organisms ! 4

Product InformationThe Laboratory Preparedness Exercise was developed as a collaborative effort between the College of AmericanPathologists, the Center for Disease Control and Prevention (CDC), and the Association of Public Health Laboratories.The purpose of LPX is to provide laboratories with an educational exercise that can be used to help prepare for thelaboratory detection of pathogens of epidemiologic importance, including pathogens that can be used as biothreatagents. Laboratories will be sent live organisms that either exhibit characteristics of bioterrorism agents ordemonstrate epidemiologic importance and will be expected to respond following Laboratory Response Networkprotocols if a bioterrorism agent is suspected. All agents provided are excluded from the CDC’s select agent list.These may include strains of Bacillus anthracis, Yersinia pestis, Francisella tularensis, and Brucella abortus thathave been modified and are safe for testing in a laboratory that contains a certified Class II Biological Safety Cabinetand is capable of handling Category A and B agents.

Laboratory Preparedness Exercise LPX

Analyte SP SP1 Challenges per ShipmentAdenovirus 40/41 ! 2Shiga Toxin ! 2Rotavirus ! 2C.difficile ! 2Norovirus ! 1

Product InformationSurvey SP is designed for laboratories performing stool pathogen testing by rapid or molecular testing methods. Eachshipment will contain two specimens. Module SP1 is for laboratories performing Norovirus testing by rapid or molec-ular testing methods. Each shipment will contain one specimen.

Stool Pathogen Survey SP, SP1 New

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Procedure E Challenges per ShipmentAcid-fast smear ! 1Antimycobacterial susceptibility testing ! 1Mycobacterial identification ! 5

Product InformationSurvey E is designed for laboratories performing comprehensive mycobacteriology procedures. Each shipment willinclude five simulated clinical isolates for mycobacterial identification by culture or molecular methods (one ofwhich is to be used for antimycobacterial susceptibility testing), plus one specimen for performing an acid-fastbacillus (AFB) smear.

Mycobacteriology E

MycobacteriologyAnalytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS).

Procedure E1 Challenges per ShipmentAcid-fast smear ! 5Mycobacterial culture ! 5

Product InformationSurvey E1 is designed for laboratories performing concentration for acid-fast bacillus (AFB) smears and/or isolatingmycobacteria to be referred to another laboratory for identification. Each shipment will include five simulatedspecimens for acid-fast smears and/or for the determination of the presence or absence of AFB by culture.

Mycobacteriology (Limited) E1

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Procedure F Challenges per ShipmentAntifungal susceptibility testing ! 1Cryptococcal antigen detection ! 2 per yearMold and yeast identification ! 5

Product InformationSurvey F is designed for laboratories performing mold and yeast identification by culture or molecular methods, withchallenges provided for yeast, dermatophytes, actinomycetes, and other molds. Laboratories offering a more limitedrange of testing should consider Survey F1. Note: Concurrent enrollment in Survey F and Survey F1 is notrecommended due to duplication of some organisms.

Each shipment will include five challenges, in duplicate, along with one antifungal susceptibility challenge. Twosimulated cerebrospinal fluid (CSF) specimens will be provided per year for cryptococcal antigen detection.Challenges for cryptococcal antigen detection will be included in the A and B shipments. Note: Thoselaboratories performing India Ink preparations may now order the CAP’s India Ink Survey IND, found onpage 139.


Mycology F

MycologyAnalytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS).

Procedure F1 Challenges per ShipmentAntifungal susceptibility testing ! 1Cryptococcal antigen detection ! 2 per yearYeast identification ! 5

Product InformationSurvey F1 is designed for laboratories performing only yeast identification by culture or molecular methods and/orcryptococcal antigen detection.

Each shipment will include five challenges, in duplicate, along with one antifungal susceptibility challenge. Twosimulated cerebrospinal fluid (CSF) specimens will be provided per year for cryptococcal antigen detection.Challenges for cryptococcal antigen detection will be included in the A and B shipments. Note: Thoselaboratories performing India Ink preparations may now order the CAP’s India Ink Survey IND, found onpage 139.

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Procedure IND Challenges per ShipmentIndia Ink ! 2

Product InformationEach shipment will include two specimens to be used for detection of capsule production. Note: Please see MycologySurveys F and F1 described on page 138, which include challenges for cryptococcal antigen detection.

India Ink IND

Receive PT results faster with e-LAB Solutions™!Improve confidence in your laboratory’s quality by accessing evaluations sooner online.Visit www.cap.org for more information.

140 Parasitology



Procedure P P3 P4 P5Fecal suspension (wet mount) ! ! !Fecal suspension (Giardia and/or ! ! ! !Cryptosporidium immunoassayand modified acid fast stain)Giemsa-stained blood smear !Preserved slide (for permanent stain) ! !Color photograph challenges ! ! !

Product InformationParasitology Survey options have been designed to allow laboratories to choose the option that most closely matchestheir test menu and ensure compliance with CLIA requirements. To meet CLIA requirements for the subspecialty ofparasitology, you must test five specimens per mailing.

Each shipment will include:! Survey P may include thin and thick film for blood or tissue parasite identification, preserved slides for

permanent stain, 0.75 fecal suspensions for direct wet mount examination or color photopages, andtwo 0.75-mL fecal suspensions for Giardia and/or Cryptosporidium immunoassay testing and modifiedacid fast stain.

! Survey P3 may include 0.75 mL fecal suspensions for direct wet mount examination or color photopages andone fecal suspension for Giardia and/or Cryptosporidium immunoassay testing and modified acid fast stain.

! Survey P4 may include 0.75 mL fecal suspensions for direct wet mount examination, preserved slides forpermanent stain, or color photopages and one 0.75 mL fecal suspension for Giardia and/or Cryptosporidiumimmunoassay testing and modified acid fast stain.

! Survey P5 will include five 0.75 mL fecal suspensions for Giardia and/or Cryptosporidium immunoassay testingand modified acid fast stain.

Note:: Laboratories that perform only Giemsa-stained blood smear should enroll in Survey BP found on page 141.

Note: Modified acid fast stain results do not meet CLIA requirements for Parasite identification.

Product Fulfillment Group P

Parasitology P, P3, P4, P5

ParasitologyAnalytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS).

Note: The proficiency materials used for Parasitology Survey contain formalin as a preservative. Check yourmethodology prior to ordering this Survey.

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Procedure BP Challenges per ShipmentThin/Thick* blood film sets, Giemsa-stained ! 5

Product InformationSurvey BP meets regulatory requirements for laboratories performing only blood parasite testing. Survey BP willconsist of five thin blood films and corresponding thick films (*when available) and/ or color photographchallenges per shipment. The samples will include a variety of blood parasites, including Plasmodium, Babesia,Trypanosoma, and a variety of filarial worms. Thick film examination is the gold standard for detection of bloodparasites, and this Survey will allow participants to periodically compare the thick and thin film appearance of avariety of blood parasites.

Blood Parasite BP

142 Virology and Molecular Microbiology Testing



Virology and Molecular Microbiology Testing

Do youperformmoleculartesting onChlamydiaor GC only

Do youperformnucleic acidamplificationother thanGC?

Do youperformviral loadtestingonly?

Do you perform any of the followingVirology testing:" Virology Culture

" Virology Antigen Testing

" Virology Antibody Testing

Select fromthefollowingSurveys:

" HC5Chlamydia/GCDNA Probeor

" HC6Chlamydia/GCNucleic AcidAmplification

Select IDO,ID1, ID1T,ID2Nucleic AcidAmplificationSurveys

Select fromthefollowingSurveys:" HIV,

HV2HIV ViralLoad

" HCVN,HCV2,HBVLHepatitisViral Load

" VLS,CMV, BK,and EBVViral LoadSurvey

Select

VR1

Select

VR2

Select

VR3

Select

VR4

Select

HC2

Select

HC4

For Comprehensive VirologyCulture Testing

For Virology AntigenTesting byImmunofluorescence

For Comprehensive VirologyAntibody Testing

For Virology Antigen by EIA orLatex Agglutination

For Herpes Simplex VirusAntigen Detection by DFA

For Herpes Simplex VirusCulture Testing

Yes

Yes Yes Yes

This flowchart is provided as a guide for ordering the appropriate Virology and Molecular Microbiology Surveys for yourlaboratory’s testing menu. In order to meet CLIA requirements for the subspecialty of virology, you must test fivespecimens per mailing. If you have any questions, please contact the CAP Customer Contact Center at 800-323-4040option 1.

Virology Molecular Microbiology

Select

VR3MFor Viral Antibody Testingfor Mumps, lgG

Virology 143


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Procedure VR1 Challenges per ShipmentChlamydia trachomatis culture ! 1Viral isolation/identification ! 5Educational challenge ! 1/per year

Virology Culture VR1

Product InformationSurvey VR1 may include the following viral cultures: adenoviruses, influenza viruses, parainfluenza viruses,respiratory syncytial virus (RSV), cytomegalovirus (CMV), herpes simplex viruses (HSV), enteroviruses,varicella-zoster virus (VZV), and Chlamydia trachomatis. Each shipment will contain five specimensfor viral isolation and identification, and one specimen for Chlamydia trachomatis culture.

Challenges per ShipmentAnalyte VR2 VR2-A VR2-B VR2-CAdenovirus antigen ! 1 1Cytomegalovirus antigen ! 1 1Herpes simplex virus (HSV) antigen ! 1 1Influenza A antigen ! 1 1Influenza B antigen ! 1Parainfluenza antigen ! 1 1Respiratory syncytial virus (RSV) antigen ! 1 1Varicella-zoster antigen ! 1 1Educational challenge 1

Product InformationSurvey VR2 is designed for participants using direct immunofluorescence (DFA) methods for viral antigen detection.Challenges are distributed in shipments as indicated above. Each shipment will contain five 5-well slides.

Virology Antigen Detection (DFA) VR2

Handle with CareSpecimens included in the Virology Surveys may contain pathogens and must be handled with extreme care.These specimens must be dealt with and disposed of only by trained laboratory personnel.

VirologyAnalytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS).

144 Virology



Analyte VR3 VR3M Challenges per ShipmentCytomegalovirus (CMV) – IgG, IgM, and total antibodies ! 1Epstein-Barr virus (EBV) – ! 1VCA: IgG, IgMEBNA: IgG, IgM, and total antibodiesEA-IgGHelicobacter pylori – IgG, IgA, and total antibodies ! 1Herpes simplex virus (HSV) – IgG antibody ! 1Mycoplasma pneumoniae – IgG, IgM, and total antibodies ! 1Mumps – IgG ! 1Rubeola virus – IgG antibody ! 1Toxoplasma gondii – IgG, IgM, and total antibodies ! 1Varicella-zoster virus – IgG and total antibodies ! 1

Product InformationVR3 will contain eight 0.5-mL lyophilized plasma specimens. VR3M will contain one 0.5-mL lyophilized plasmaspecimen.

Product Fulfillment Group VR3

Virology Antibody Detection VR3, VR3M

Analyte VR4 Challenges per ShipmentAdenovirus (Not 40/41) antigen ! 5Influenza A antigen ! 5Influenza B antigen ! 5Respiratory syncytial virus (RSV) antigen ! 5Rotavirus antigen ! 5

Product InformationSurvey VR4 is designed for participants using enzyme immunoassay and/or latex agglutination methods for viralantigen detection. Challenges may be tested for any or all of the listed viruses. Each shipment will contain fivespecimens. Participants are instructed to test for all viruses tested in their laboratories.

Virology Antigen Detection VR4

Virology 145


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Analyte TTD Challenges per ShipmentAntibody to tick-transmitted disease organisms ! 3

Tick-Transmitted Diseases TTD

Product InformationSurvey TTD includes three liquid specimens for the detection of antibodies to Borrelia burgdorferi,Babesia microti, and Anaplasma phagocytophilum.

Want to stay tuned to the latest developments inlaboratory medicine?Be sure to read CAP TODAY®!

This monthly publication, recognized as the premier publication for laboratory information,is filled with important and relevant articles on a myriad of topics, ranging from newtechnological developments to health care market dynamics, and many other topics. Freeto all qualified laboratorians.

146 Virology



Procedure HC1 HC2 HC3 HC4* HC5* HC6* HC6X* Challenges per ShipmentChlamydia trachomatis

Antigen detection (DFA) ! 5Enzyme immunoassay (EIA) ! 5DNA probe ! 5Nucleic acid amplification (NAA) ! ! 5

Herpes simplex virus (HSV)Antigen detection (DFA) ! 5Culture ! 5

Neisseria gonorrhoeaeDNA probe ! 5Nucleic acid amplification (NAA) ! ! 5

Product InformationConcurrent enrollment in Surveys HC2 and HC4 is not recommended. (Laboratories confirming HSV cultures bydirect immunofluorescent methods should enroll in Survey HC4 only.) Survey HC5 cannot be used for nucleic acidamplification (NAA) methods; laboratories using NAA technology for C. trachomatis and N. gonorrhoeae shouldorder Survey HC6. Laboratories using DNA probe methods for C. trachomatis and N. gonorrhoeae should orderSurvey HC5.

HC1 C. trachomatis antigen detection (DFA) Five 5-well slidesHC2 Herpes simplex virus antigen detection (DFA) Five 5-well slidesHC3 C. trachomatis antigen detection (EIA) Five 2.0-mL liquid specimensHC4 Herpes simplex virus culture Five 2.0-mL viral suspensionsHC5 C. trachomatis and N. gonorrhoeae Five swab specimens**

by DNA probeHC6 C. trachomatis and N. gonorrhoeae Three swab specimens** and two simulated

by nucleic acid amplification urine specimens

HC6X C. trachomatis and N. gonorrhoeae Three swab specimens** and two simulated urineby nucleic acid amplification specimens (each sent in duplicate) for those methods

that require additional volume.** For Surveys HC5, HC6, and HC6X, each swab is used to perform both C. trachomatis and N. gonorrhoeae testing.

C. trachomatis, Herpes, N. gonorrhoeae HC1-HC6, HC6X

*Biohazard warning refers to Surveys HC4, HC5, HC6, and HC6X.

Molecular Microbiology 147


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Procedure HIV HV2 Challenges per ShipmentHIV-RNA viral load ! ! 5HIV genotyping ! ! 1

Product InformationSurvey HIV is designed for laboratories performing analysis of human immunodeficiency virus (HIV) by nucleic acidamplification and will include quantitative challenges. Survey HV2 is an available option with additional material forusers of methods requiring a testing volume greater than 0.5-mL. Surveys HIV and HV2 are also available forlaboratories performing genotyping. Each shipment of Survey HIV will contain five 0.5-mL specimens. Each shipmentof Survey HV2 will contain five 2.5-mL specimens.

Product Fulfillment Group HIV

HIV Viral Load HIV, HV2

Molecular MicrobiologyAnalytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS).

Procedure HCVN HCV2 HBVL Challenges per ShipmentHCV viral load ! ! 5HCV genotyping ! ! 1HCV, qualitative ! ! 1HBV viral load ! 1

Hepatitis Viral Load HCVN, HCV2, HBVL

Product InformationSurvey HCVN is designed for laboratories performing analysis of hepatitis virus by nucleic acid amplification and willinclude quantitative challenges. Survey HCV2 is an available option with additional material for users of methodsrequiring a testing volume greater than 0.5-mL. Surveys HCVN and HCV2 may also be used by laboratories performingqualitative analysis and genotyping.

Each shipment of Survey HCVN will contain five 0.5-mL liquid specimens. Each shipment of Survey HCV2 will containfive 1.5-mL liquid simulated plasma specimens.

Survey HBVL allows laboratories to perform quantitative testing for Hepatitis B virus by nucleic acid amplification.Each shipment of HBVL will contain one plasma specimen.

Product Fulfillment Group HVL

148 Molecular Microbiology



Procedure VLS Challenges per ShipmentCMV viral load ! 2EBV viral load ! 2BK viral load ! 2

Viral Load Survey VLS

Product InformationSurvey VLS is designed for laboratories performing analysis of viral load by nucleic acid amplification and willinclude quantitative challenges. Each shipment will include six 1.0-mL EDTA plasma specimens.

Molecular Microbiology 149


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Analyte/Procedure IDO Challenges per ShipmentMolecular Typing (bacterial isolates) ! 1Vancomycin resistant Enterococcus ! 1Mycobacterium tuberculosis ! 1Bordetella pertussis/parapertussis ! 1Methicillin resistant Staphylococcus aureus ! 1Mycoplasma pneumoniae ! 1Legionella pneumophila /Chlamydiophila pneumoniae ! 1

Product InformationSurvey IDO is intended for advanced clinical microbiology or special-function laboratories performing nucleic acidamplification techniques (ie, PCR, LCR, bDNA, NASBA). This Survey is not intended to meet requirements forprocedures regulated for proficiency testing. Each shipment will contain serum, plasma, or simulated clinicalisolate specimens.

Nucleic Acid Amplification, Organisms IDO

Analyte ID1 1D1T Challenges per ShipmentEnterovirus ! 1Epstein-Barr virus ! 1Cytomegalovirus ! 1Herpes simplex virus ! 1Human herpesvirus 6 ! 1Human herpesvirus 8 ! 1Parvovirus B19 ! 1Varicella-zoster virus ! 1BK virus ! 1JC virus ! 1

Product InformationSurveys ID1 and ID1T are intended for advanced clinical microbiology or special-function laboratories performingnucleic acid amplification techniques (ie, PCR, LCR, bDNA, NASBA). These Surveys are not intended to meetrequirements for procedures regulated for proficiency testing. Each shipment will contain serum, plasma, orsimulated clinical isolate specimens.

Nucleic Acid Amplification, Viruses ID1 and ID1T

New

New

150 Molecular Microbiology



Analyte HPV Challenges per ShipmentHuman papillomavirus ! 2

Human papillomavirus HPV

Product InformationSurvey HPV is for laboratories performing nucleic acid amplification techniques for HPV. Each shipment will includesimulated cervical specimens contained in Digene transport media. Note: This Survey is not intended to meetrequirements for procedures regulated for proficiency testing. This material is not compatible with Third Wavetechnology. The CAP recommends that Third Wave users enroll in the one of the CHPV Surveys on page 204.

Analyte ID2 Challenges per ShipmentInfluenza virus ! 1Parainfluenza virus ! 1Respiratory syncytial virus ! 1Adenovirus ! 1Human metapneumovirus ! 1Coronavirus/Rhinovirus ! 1

Product InformationSurvey ID2 is intended for advanced clinical microbiology or special-function laboratories performing nucleic acidamplification techniques (ie, PCR, LCR, bDNA, NASBA). This Survey is not intended to meet requirements forprocedures regulated for proficiency testing. Each shipment will contain serum, plasma, or simulated clinical isolatespecimens.

Nucleic Acid Amplification, Respiratory ID2 New

16IMMUNOLOGY

AND FLOW CYTOMETRY

New for 2009! Total Hemolytic Complement (CH50)

! Flow Cytometry, Interpretation Only (FL5)

Immunology ......................................................................151

Flow Cytometry ................................................................159

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Immunology 151


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Analyte ANA ASO CRP HCG IM IMW RF RFX RUB RUBX IL Challengesper Shipment

Antinuclear antibody(ANA)* ! ! 5Anti-streptolysin O(ASO)** ! ! 5C-reactive protein(qualitative andquantitative) ! ! 2hCG, serum (qualitativeand quantitative) ! ! 5Infectiousmononucleosis ! ! 5Infectious mononucleosis,waived ! 3Rheumatoid factor** ! ! ! 5Rubella** ! ! ! 5

Product InformationEach of the seven analytes listed in the above Immunology Surveys are designed to be ordered separately and can becombined as needed to meet your laboratory’s individual testing requirements. The CRP Survey is not designed forhigh-sensitivity CRP methods. See page 152 for the High-Sensitivity C-reactive Protein Survey (hsCRP).Note: Survey IL is also available for laboratories requiring proficiency testing for all seven analytes.

Each shipment of Surveys ANA and RUB will include five 0.5-mL serum specimens. Survey CRP will include two0.5-mL serum specimens. For Surveys ASO, hCG, and RF each shipment will include five 1.0-mL serumspecimens. Survey IM will include five 0.6-mL serum specimens. Survey IMW will include three 0.6-mL serumspecimens.

Survey IL will contain all the specimens with the exception of IMW.Survey RFX will include ten 1.0-mL serum specimens.Survey RUBX will include ten 0.5-mL serum specimens.


Product Fulfillment Groups S and IMW (infectious mononucleosis, waived)

Analytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services

Immunology

* Antinuclear antibody (ANA) is regulated and graded for qualitative methods. The quantitative methods are graded but do not meetregulatory requirements. Titer results will be ungraded/educational in this Survey and do not meet regulatory requirements.

**Anti-streptolysin O (ASO), Rheumatoid factor, and Rubella are regulated analytes and graded for both qualitative and quantitative methods.Semi-quantitative and/or titer results for these analytes are ungraded/educational in this Survey and do not meet regulatory requirements.

ImmunologyCE

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152 Immunology



Analyte CH50 Challenges per ShipmentTotal Hemolytic Complement ! 2

Product InformationSurvey CH50 is designed to test the functional activity of the classical complement pathway.

Each shipment will contain two lyophilized serum specimens.

Analyte IG IGX Challenges per ShipmentAlpha-1-antitrypsin ! ! 5Complement C3 ! ! 5Complement C4 ! ! 5Haptoglobin ! ! 5IgA ! ! 5IgE ! ! 5IgG ! ! 5IgM ! ! 5Kappa/Lambda ratio ! ! 5

Product InformationWith each shipment of Survey IG, participants will receive five 1.0-mL serum specimens for quantitation ofimmunoglobulins, haptoglobin, kappa/lambda ratios, and alpha-1-antitrypsin; and five 1.0-mL lyophilized serumspecimens for complement C3 and C4. Survey IGX will include ten 1.0-mL liquid serum specimens and ten 1.0-mLlyophilized serum specimens.

Immunology (General) IG, IGX

Total Hemolytic Complement CH50

Analyte hsCRP Challenges per ShipmentHigh-sensitivity C-reactive protein ! 3

Product InformationSurvey hsCRP is designed for participants performing high-sensitivity C-reactive protein testing, ie, less than50 mg/L. Each shipment will include three 0.5-mL serum specimens.


High-Sensitivity C-reactive Protein hsCRP

Immunology 153


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Challenges per ShipmentAnalyte S2 S4 S5 A B CAnti-DNA antibody (ds) ! ! 1 1 1Anti-glomerular basement membrane antibody ! 1 1Antimitochondrial antibody ! 1 1 1Antineutrophil cytoplasmic antibody(ANCA, anti-MPO, anti-PR3) ! 1 1Anti-RNP antibody ! 1 1 1Anti-Sm antibody ! 1 1 1Anti-Sm/RNP antibody ! 1 1 1Anti-smooth muscle antibody ! 1 1 1Anti-SSA antibody ! 1 1Anti-SSB antibody ! 1 1Anti-SSA/SSB antibody ! 1 1Antithyroglobulin antibody ! ! 1 1 1Antithyroid microsomal antibody ! ! 1 1 1Antithyroid peroxidase antibody ! ! 1 1 1Ceruloplasmin ! ! 1 1Haptoglobin ! ! 1 1Helicobacter pylori, IgG antibody ! ! 1 1

! 2 2IgD ! ! 1 1 1IgG ! ! 1 1IgG subclass proteins ! ! 1 1Kappa/lambda ratio ! ! 1 1Prealbumin (transthyretin) ! ! 1 1Transferrin ! ! 1 1

Product InformationThe S4 and S5 Survey options are provided for laboratories that peform limited special immunology testing.

Each shipment of Survey S2 will include a minimum of five (0.5-to 1.0-mL per vial) serum specimens and two (0.5-to 1.0-mL per vial) lyophilized serum specimens. Each shipment of Survey S4 will include a minimum of three (0.5-to 1.0-mL per vial) serum specimens. Each shipment of Survey S5 will include two 1.0-mL serum specimens.

Product Fulfillment Group S2

Immunology (Special), Immunology (Special, Limited),H. Pylori IgG Antibody S2, S4, S5

154 Immunology



Analyte H Challenges per ShipmentAntimitochondrial M2 antibody (AMA-M2) ! 2


Product Fulfillment Group GIH

Analyte APC Challenges per ShipmentAnti-parietal cell antibody ! 2



Analyte V Challenges per ShipmentViscosity ! 2


Antimitochondrial M2 Antibody H

Anti-Parietal Cell Antibody APC

Viscosity V

Immunology 155


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Analyte ASC Challenges per ShipmentAnti-Saccharomyces cerevisiae antibody ! 2


Analyte LKM Challenges per ShipmentLiver-kidney microsomal antibody (Anti-LKM) ! 2



Anti-Saccharomyces cerevisiae Antibody ASC

Liver-Kidney Microsomal Antibody (Anti-LKM) LKM

156 Immunology



Analyte CCP Challenges per ShipmentAnti-CCP ! 2

Product InformationEach shipment contains two 1.0-mL serum specimens.

Product Fulfillment Group RDS

Cyclic Citrullinated Peptide Antibody (Anti-CCP) CCP

Analyte RDS Challenges per ShipmentAnti-Jo-1 (anti-histidyl t-RNA synthetase) ! 1Anti-Scl-70 (anti-DNA topoisomerase) ! 1


Product Fulfillment Group RDS

Rheumatic Disease Special Serologies RDS

Immunology 157


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Analyte ACL Challenges per ShipmentAnticardiolipin antibody ! 3Beta-2-glycoprotein I ! 3

Challenges per ShipmentAnalyte CES A BAnti-endomysial (IgA) ! 2 3Anti-endomysial (IgG) ! 2 3Anti-gliadin (IgA) ! 2 3Anti-gliadin (IgG) ! 2 3Anti-deamidated gliadin peptide (IgA) ! 2 3Anti-deamidated gliadin peptide (IgG) ! 2 3Anti-deamidated gliadin peptide screen (IgA, IgG) ! 2 3Anti-tissue transglutaminase (IgA) ! 2 3Anti-tissue transglutaminase (IgG) ! 2 3Anti-deamidated gliadin peptide (IgA, IgG) and ! 2 3Anti-tissue-transglutaminase (IgA, IgG) screen

Product InformationEach shipment will include the appropriate number of 0.3-mL serum specimens.

Product InformationEach shipment will include three 0.5-mL lyophilized serum specimens.

Antiphospholipid Antibody ACL

Celiac Serology CES

158 Immunology



Analyte/Procedure SE Challenges per ShipmentIgE, total ! 5IgE multi-allergen screen (qualitative) ! 5Specific allergens ! 25Educational challenges ! 2 per year

Product InformationSurvey SE is designed to provide the allergy laboratory with allergen-specific IgE and total serum IgE. Commonallergens are selected from North America, as well as less frequently tested allergens.

Survey specimens are prepared from individual allergic sera that have been based on a clinical history and/or skintest reactivity of the donors. Each shipment will contain five 2.0-mL serum specimens, each to be tested for fivespecific IgE antibodies and total IgE. Twice a year, an additional educational allergen challenge will be included.

Analyte G Challenges per ShipmentSyphilis ! 5

Product InformationSurvey G can be used for VDRL, RPR, MHA-TP/TP-PA/PK-TP, EIA, CMIA, multiplex flow immunoassay, FTA-ABS, andUSR methods. Laboratories performing syphilis serology testing on cerebrospinal fluid only may also use this Survey.Each shipment will include five 1.5-mL serum specimens.

Diagnostic Allergy SE

Syphilis Serology G

Flow Cytometry 159


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Procedure FL FL1 FL2 Challenges per ShipmentDNA content and cell cycle analysis ! ! 3Lymphocyte immunophenotyping ! ! 3

Product InformationSurveys FL, FL1, and FL2 are designed to test the ability of participating laboratories to correctly identify andenumerate subpopulations of lymphocytes and/or perform DNA content and cell cycle analysis. Survey FL1 shipmentswill include three whole blood specimens for lymphocyte immunophenotyping and enumeration of lymphocytesubsets. Survey FL2 shipments will contain two fixed cell-line specimens and one calibrator for DNA content and cellcycle analysis. Survey FL shipments will include specimens from both Surveys FL1 and FL2.

Product Fulfillment Group FL


Flow Cytometry

Analyte FL3 FL3CD Challenges per ShipmentLeukemia/lymphoma ! 2Leukemia/lymphoma list-mode challenge (CD-ROM) ! 2

Product InformationSurvey FL3 allows participants to evaluate their performance by comparing their results with those laboratories usingsimilar instruments and reagents. Survey FL3 contains two whole blood specimens and/or cell lines simulatingleukemia/lymphoma. Photopages of tissue sections or bone marrow smears and clinical histories are also provided.

Survey FL3CD is a CD-ROM-based educational module. This CD-ROM contains list mode files from cases of leukemiaand lymphoma and allows the user to examine gating strategies and interpretation of antibody staining patterns. Thefiles are in standard FCS 2.0 format and work well with CellQuest, System II, Expo 32, and other software capable ofreading the FCS 2.0 files. Survey FL3CD is provided on a single CD-ROM disk per shipment and includes two cases,each with clinical histories, photomicrographs, and ungated list mode files.

An education activity is planned for the FL3CD Survey that includes reading material found in the ParticipantSummary and online learning assessment questions. All laboratory staff can participate individually and earn free CEcredit without leaving the laboratory.

Flow Cytometry FL, FL1, FL2

Flow Cytometry—Immunophenotypic FL3, FL3CDCE

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160 Flow Cytometry



Analyte FL4 Challenges per ShipmentAnalyte FL4 Challenges per ShipmentCD34+ ! 2

Product InformationThis Survey is designed to test the ability of participating laboratories to correctly enumerate CD34+ cells. Survey FL4will include two shipments per year, each containing two stabilized human CD34+ specimens.

Analyte PNH PNHW Challenges per ShipmentPNH RBC analysis (CD55/CD59) ! 2PNH WBC analysis (CD55/CD59, FLAER) ! 2

Product InformationSurvey PNH is designed for laboratories performing PNH testing by flow cytometry using CD55 and CD59 on redblood cell populations. Survey PNHW is intended for PNH testing by flow cytometry using white blood cells (WBC).Each shipment of PNH will contain two 1.0-mL red blood cell specimens.Each shipment of PNHW will contain two 3.5-mL cell line specimens.

Product Fulfillment Group PNH

Flow Cytometry—CD34+ FL4

Flow Cytometry—Immunophenotypic Characterization ofParoxysmal Nocturnal Hemoglobinuria PNH, PNHW

Analyte FL5 Challenges per ShipmentFlow cytometry, interpretation only ! 2

Product InformationSurvey FL5 is a proficiency testing program for laboratories that interpret and report the results of flow cytometryanalyses performed in another laboratory. Survey FL5 is designed to allow laboratories to evaluate their performancewith other laboratories performing only the interpretation of flow cytometry. Survey FL5 will contain 2 cases consist-ing of gated dot plots, clinical histories, pertinent laboratory data, and may include images of tissue sections, bonemarrow, and peripheral blood smears.


Flow Cytometry—Interpretation Only FL5CE

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Flow Cytometry 161


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Analyte FL4 Challenges per ShipmentAnalyte QF Challenges per ShipmentM. tuberculosis infection detection ! 2

Product InformationSurvey QF is designed for laboratories detecting M. tuberculosis using the QuantiFERON®TB method. Eachshipment will include two 1.0 mL specimens for the qualitative detection of cell mediated immune responsethrough release of gamma interferon to M. tuberculosis.

M. tuberculosis Stimulated Infection Detection QF

Analyte/Procedure HBF Challenges per ShipmentFetal RBCs, qualitative (Rosette fetal screen) ! 2Fetal RBCs, quantitative (Kleihauer-Batke, Flow Cytometry) ! 2




17TRANSFUSION MEDICINE,

TRANSFUSION-TRANSMITTED VIRUSES,AND PARENTAGE/RELATIONSHIP TESTING

New for 2009! Bacterial Detection in Platelets (BDP)! Viral Markers Series 5 (VM5)

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Transfusion Medicine..........................................................163

Transfusion-Transmitted Viruses ............................................172

Parentage/Relationship Testing ............................................176

Subdisc ip l ines

Transfusion Medicine 163


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Procedure J J1 Challenges per ShipmentABO grouping ! ! 5Rh typing ! ! 5Antibody detection ! 5Antibody identification ! 5Compatibility testing ! 5Red blood cell antigen detection ! 1


Transfusion Medicine

Product InformationSurveys J and J1 are designed for pretransfusion testing by manual techniques. See the Transfusion MedicineAutomated Testing Survey (JAT) for automated instruments on page 165. For additional educational challenges tocomplement your proficiency testing, refer to Survey JE1 (see page 166).

For competency assessment of technologists’ ability to perform comprehensive pretransfusion testing, pleaserefer to Survey TMCA, Transfusion Medicine Competency Assessment–Comprehensive Transfusion Medicine.

Each shipment will include five 2.0-mL specimens of a 3% red blood cell suspension and five 3.0-mL correspondingserum specimens. Survey J shipments will also include one 2.0-mL donor red blood cell suspension.


CE

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Transfusion Medicine (Comprehensive, Limited) J, J1

164 Transfusion Medicine



Analyte CBT Challenges per ShipmentAbsolute CD3 ! 2Absolute CD34 ! 2Absolute CD45 ! 2Bacterial culture ! 2% CD3+ ! 2% CD34+ ! 2% CD45+ ! 2BFU-E ! 2CFU-E ! 2CFU-GEMM ! 2CFU-GM ! 2Total CFC ! 2Fungal culture ! 2Hematocrit ! 2Hemoglobin ! 2Mononuclear cell count ! 2Total nucleated cells ! 2Total nucleated red cells ! 2Viability ! 2WBC count ! 2

Cord Blood CBT

Product InformationEach shipment will include two specimens for the proficiency testing of assays required for the production ofumbilical cord blood stem cell products.

Due to the unique nature of these materials that are human donor based, the shipping date is subject to change. Ifthis should occur, a notification will be provided prior to the originally scheduled date. In some instances, theproduct may ship in two installments.

Due to material stability, no replacements will be available.



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Procedure JAT Challenges per ShipmentABO grouping ! 5Antibody detection ! 5Rh typing ! 5Antibody detection ! 5

Product InformationSurvey JAT is designed for automated blood banking instruments. For antibody identification and compatibility testingby manual techniques, refer to Survey J (see page 163).

For competency assessment of technologists’ ability to perform comprehensive pretransfusion testing, pleaserefer to Survey TMCA, Transfusion Medicine Competency Assessment–Comprehensive Transfusion Medicine.

Each shipment will include five specimens.

Transfusion Medicine Automated Testing JAT

Procedure DAT Challenges per ShipmentDirect antiglobulin testing ! 3

Product InformationSurvey DAT is designed for laboratories performing direct antiglobulin testing as a stand-alone test or as part of anyof the following work-ups: pretransfusion compatibility testing, transfusion reaction, autoimmune hemolytic anemia,and/or hemolytic disease of the newborn. Each shipment will include three 2.0-mL specimens of a 3-4% red bloodcell suspension.

For competency assessment of technologists’ ability to perform direct antiglobulin testing, please refer toSurvey TMCAD, Transfusion Medicine Competency Assessment–Direct Antiglobulin Test.

Direct Antiglobulin Testing DAT




Procedure TMCA Challenges per ShipmentABO grouping ! 2Antibody detection ! 2Antibody identification ! 2Compatibility testing ! 2Rh typing ! 2

Product InformationSurvey TMCA is designed for laboratory directors and managers to assess the competency of their technical staff inperforming routine pretransfusion testing. Shipments may be ordered individually or for an entire year. Intendedresponses will be mailed to participants approximately four weeks after receipt, enabling laboratory managers ordirectors to perform an evaluation of technologist performance.

Each shipment of Survey TMCA will contain two 2.0-mL specimens of a 3% red blood cell suspension and two 3.0-mLcorresponding serum specimens, along with one donor 3.0-mL 3% red blood cell suspension.

Transfusion Medicine Competency Assessment—Comprehensive Transfusion Medicine TMCA

Note: Shipments may be ordered individually.

Analyte/Program JE1 Challenges per ShipmentEducational challenge ! 1

Product InformationSurvey JE1 provides maximum educational benefits for laboratories performing comprehensive Transfusion Medicinetesting. A variety of Transfusion Medicine challenges comprise Survey JE1. These may include, but are not limited to,paper challenges, serum specimens for antibody detection and identification, red blood cell suspensions for ABOgrouping, Rh typing, and direct antiglobulin testing, and/or 35mm slide challenges. Survey JEI must be purchasedin conjunction with Survey J.

An education activity is planned that includes reading material found in the Final Critique and online learningassessment questions. All laboratory staff can participate individually and earn free CE credit without leaving thelaboratory.

Product Fulfillment Group J

Transfusion Medicine—Educational Challenges JE1

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Procedure TMCAD Challenges per ShipmentDirect antiglobulin testing ! 2

Product InformationSurvey TMCAD is designed for laboratory directors and managers to assess the competency of their technical staffin performing direct antiglobulin testing. Shipments may be ordered individually or for an entire year. Intendedresponses will be mailed to participants approximately four weeks after receipt, enabling laboratory managers ordirectors to perform an evaluation of technologist performance. Each shipment of Survey TMCAD will contain two2.0-mL specimens of a 3-4% red blood cell suspension.


Transfusion Medicine Competency Assessment–Direct Antiglobulin Test TMCAD

Analyte/Procedure HBF Challenges per ShipmentFetal RBCs, qualitative (Rosette fetal screen) ! 2Fetal RBCs, quantitative (Kleihauer-Betke, Flow Cytomety) ! 2







Procedure PS Challenges per ShipmentAntibody detection ! 3Platelet crossmatch ! 3

Product InformationSurvey PS participants will crossmatch each plasma specimen provided with ten units of platelets from theirinstitution and report the percentage of units that are serologically incompatible. Participants will also report resultsof an antibody screen. Note: A low concentration of sodium azide may be present in the specimens and mayaffect lymphocytotoxicity methods. Each shipment will include three 3.0-mL plasma specimens. This material iscompatible with solid-phase red cell adherence, flow cytometry, EIA/ELISA, and RIA methods.

Platelet Serology PS

Analyte/Procedure TMCAF Challenges per ShipmentFetal RBCs, qualitative (Rosette fetal screen) ! 2Fetal RBCs, quantitative (Kleihauer-Betke, Flow Cytomety) ! 2

Product InformationSurvey TMCAF is designed for laboratory directors and managers to assess the competency of their technical staff inperforming qualitative (Rosette) and/or quantitative (Kleihauer-Betke or flow cytometry) tests for fetal red blood cellsin maternal blood. Survey TMCAF is not compatible with quantitation of (adult) F cells by flow cytometry. Shipmentsmay be ordered individually or for an entire year. Intended responses will be mailed to participants approximatelyfour to six weeks after kit receipt, enabling laboratory managers or directors to perform a self-evaluation of technol-ogist performance. Each shipment of Survey TMCAF will contain two 1.2-mL specimens of stabilized red blood cells.


Transfusion Medicine Competency Assessment–Fetal Red Cell Quantitation TMCAF



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Procedure SCP Challenges per ShipmentAbsolute CD3 ! 2Absolute CD34 ! 2Bacterial culture ! 2% CD3 ! 2% CD34+ ! 2% CD45+ ! 2BFU-E ! 2CFU-E ! 2CFU-GEMM ! 2CFU-GM ! 2Total CFC ! 2Fungal culture ! 2Hematocrit ! 2Hemoglobin ! 2Mononuclear cell count ! 2Total nucleated cells ! 2Total nucleated red cells ! 2Viability ! 2WBC count ! 2

Product InformationSurvey SCP is designed for laboratories processing and handling stem cells. The Survey will assess each laboratory’sability to determine if a stem cell product is suitable for use based on the results of the above analytes. The Surveywill contain two specimens of peripheral blood for laboratory analysis. Due to the unique nature of these materialsthat are human donor based, the shipping date is subject to change. If this should occur, a notification will be provid-ed prior to the originally scheduled date. In some instances, the product may ship in two installments.

Stem Cell Processing SCP

Analyte VMC Challenges per ShipmentAlanine aminotransferase (ALT/SGPT) ! 5Cholesterol ! 5Protein, total ! 5

Product InformationSurvey VMC is designed for laboratories performing viral markers testing and alanine aminotransferase,cholesterol, or total protein testing. Each shipment will include five 5.0-mL liquid plasma specimens.

Viral Marker Chemistry VMC




Procedure ELU Challenges per ShipmentAntibody elution ! 2

Product InformationSurvey ELU is designed for laboratories performing antibody elutions (for non-ABO antibodies) as a part of anantibody identification workup or direct antiglobulin test. Each shipment will include two 2.0-mL 50% red blood cellsuspension specimens for use in performing antibody elutions.

Eluate Survey ELU

Procedure TRC Challenges per ShipmentPlatelet count (Platelet-Rich Plasma) ! 5WBC count (Leukocyte-Reduced Platelet Suspension) ! 2WBC count (Leukocyte-Reduced Red Blood Cell Suspension) ! 2

Product InformationSurvey TRC provides Hematology and/or Transfusion Medicine laboratories with proficiency testing material forvarious cell count procedures. The Platelet-Rich Plasma material can be utilized for both manual and automatedplatelet count methods. The Leukocyte-Reduced Red Blood Cell suspensions and Leukocyte-Reduced Plateletsuspensions provide laboratories with an opportunity to assess their ability to perform low white blood cell (WBC)counts. Note: The Leukocyte-Reduced Red Blood Cell and the Leukocyte-Reduced Platelet materialsmust be used with a Nageotte chamber or flow cytometry.

Each shipment will include five 1.2-mL suspensions of stabilized mammalian Platelets (Platelet-Rich Plasma),two 1.0-mL suspensions of a Leukocyte-Reduced Red Blood Cell material, and two 1.0-mL suspensions of aLeukocyte-Reduced Platelet material.

Transfusion-Related Cell Count TRC



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Analyte/Procedure ABT ABT1 ABT2 Challenges per ShipmentAnti-A Titer ! ! 1Anti-D Titer ! ! 1

Product InformationSurvey ABT is designed for laboratories performing red cell antibody titers as a part of any of the following workups:a prenatal antibody quantification workup; the management of recipients of ABO incompatible bone marrowtransplants; to determine eligibility of O or B kidney transplant recipient candidates for receiving an A2 kidney;and/or to assess the need and monitor the effect of plasma exchange in transplant recipients who are ABOincompatible with their donors.

Survey ABT1 is designed for laboratories performing titers for Anti-A.

Survey ABT2 is designed for laboratories performing titers for Anti-D.

Laboratories ordering Surveys ABT, ABT1, or ABT2 will be able to report using a variety of techniques.

Each shipment of Survey ABT will include one plasma specimen for anti-D titer with one corresponding titer cell (3%red blood cell suspension) and one plasma specimen for anti-A titer with one corresponding titer cell (3% red bloodcell suspension). Each shipment of Survey ABT1 will include one plasma specimen for anti-A titer with onecorresponding titer cell (3% red blood cell suspension). Each shipment of Survey ABT2 will include one plasmaspecimen for anti-D titer, with one corresponding titer cell (3% red blood cell suspension).

Antibody Titer ABT, ABT1, ABT2

Procedure BDP Challenges per ShipmentBacterial culture and detection systems ! 2Glucose ! 2Gram Stain ! 2pH ! 2Rapid Immunoassay (Verax Bioscience) ! 2

Product InformationEach shipment will include two challenges for bacterial detection in platelets. Each challenge will consist oflyophilized and liquid specimens to simulate a platelet sample.

Bacterial Detection in Platelets BDP

172 Transfusion-Transmitted Viruses



Analyte VM1 Challenges per ShipmentAnti-HAV, total ! 5Anti-HBc, total ! 5Anti-HBs ! 5Anti-HCV ! 5Anti-HIV-1 ! 5Anti-HIV-1/2 ! 5Anti-HIV-2 ! 5HBsAg ! 5

Transfusion-Transmitted Viruses

Product InformationSurvey VM1 is designed for laboratories performing general viral marker testing. Reporting areas for HIV-1 and HIV-2Western Blot testing will be provided. Each shipment will include five 3.5-mL liquid serum specimens.

Note: Survey VM1 material is not compatible with rapid anti-HIV-1 or anti-HIV1/2 kits. Please enroll in SurveysRHIV, RHIVW, AHIV, or AHIVW (page 174) if using a rapid kit.

Product Fulfillment Group VM


The CAP and AABB provide jointly sponsored proficiency testing programs for laboratories involved in testing donor bloodand diagnostic clinical patient samples for serologic markers of hepatitis and other transfusion-related diseases, as well asfor parentage testing. These programs include Viral Marker Series 1, Series 2, Series 3, and Series 5 (Surveys VM1, VM2,VM3, and VM5), and the Parentage Testing Programs (PAR, PARF). For assistance in determining which Viral Marker Seriesis appropriate for your laboratory’s needs, contact a CAP Customer Contact Center Representative at 800-323-4040 option 1.

AABB/CAP Viral Markers—Series 1 VM1

Handle with CareSpecimens included in this section may contain pathogens and must be handled withextreme care. These specimens must be dealt with and disposed of only by trained laboratorypersonnel. Treat specimens as though they are capable of transmitting hepatitis and/orother blood-borne diseases.

Transfusion-Transmitted Viruses 173


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Analyte VM2 Challenges per ShipmentAnti-HBe ! 5HBeAg ! 5

Product InformationEach shipment will include five 3.5-mL liquid serum specimens.


Analyte VM3 Challenges per ShipmentAnti-CMV ! 3Anti-HTLV-I/II ! 3HIV-1 p24 antigen ! 3

Product InformationReporting areas for HTLV-I Western Blot testing will be provided. Each shipment will include three 3.5-mL liquidserum specimens.




Analyte VM4 Challenges per ShipmentAnti-Trypanosoma cruzi (Chagas Disease) ! 2

Product InformationEach shipment will include two 1.0 mL specimens for the qualitative detection of antibodies to T. cruzi.


Viral Markers—Series 4 VM4

174 Transfusion-Transmitted Viruses



Analyte AHIV AHIVW Challenges per ShipmentAnti-HIV-1/2 ! 5Anti-HIV-1/2, waived ! 2

Product InformationSurvey AHIV is designed for laboratories performing anti-HIV-1/2 testing using a rapid method. Second methodreporting is now available with Survey AHIV. Survey AHIVW is designed for laboratories performing anti-HIV-1/2testing using a waived method; space will be provided for reporting anti-HIV-1/2 for up to five different locationswithin your institution.

Anti-HIV-1/2 AHIV, AHIVW

Analyte RHIV RHIVW Challenges per ShipmentAnti-HIV-1 ! 5Anti-HIV-1, waived ! 2

Product InformationSurvey RHIV is designed for laboratories performing anti-HIV-1 testing using a rapid method. Survey RHIVW isdesigned for laboratories performing anti-HIV-1 using a waived method; space is provided for reporting anti-HIV-1results for up to five different locations within your institution.

Note: Both Survey RHIV and RHIVW are compatible with the OraQuick® Rapid HIV-1 Antibody Test kit byOraSure Technologies and the Uni-Gold™ Recombigen® HIV kit by Trinity Biotech. Survey RHIV is compatiblewith the MedMira Reveal™ HIV-1 Antibody Test kit.

Anti-HIV-1 RHIV, RHIVW

Analyte VM5 Challenges per ShipmentAnti-HAV, IgM ! 5Anti-HBc, IgM ! 5

Product InformationEach shipment will include five liquid serum specimens.


Viral Markers – Series 5 VM5

Transfusion-Transmitted Viruses 175


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Procedure NAT Challenges per ShipmentNucleic acid testing for HBV ! 5Nucleic acid testing for HIV ! 5Nucleic acid testing for HCV ! 5Nucleic acid testing for West Nile Virus ! 5

Product InformationSurvey NAT is designed for blood donor centers currently performing HBV, HCV, WNV, and/or HIV nucleic acid testingon donor units. Results will be reported qualitatively.

Each shipment will include five 6.0-mL plasma specimens.

Nucleic Acid Testing NAT

176 Parentage/Relationship Testing



Analyte/Procedure PAR PARF Challenges per ShipmentCalculation challenge ! ! 1DNA testing (PCR) ! ! 4

Product InformationEach shipment of Survey PAR will include three liquid whole blood paternity trio specimens. Survey PARF will includethree blood-stained filter paper paternity trio specimens. A buccal swab will be provided for a second alleged fatherchallenge in Surveys PAR and PARF. Participants may report results for short tandem repeats (STRs), Y-STRs, as wellas the conclusions. Note: The calculation exercise is a paper challenge.

Parentage/Relationship TestingAnalytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS).

AABB/CAP Parentage/Relationship Testing PAR, PARF

18HISTOCOMPATIBIL ITY

His

toco

mpa

tibili

ty

CAP Accreditation Receives UNOS ApprovalThe United Network for Organ Sharing (UNOS) has recognized the CAP LaboratoryAccreditation Program as an approved accreditor for UNOS laboratories. Considerusing the CAP to meet all of your UNOS accreditation requirements.

Histocompatibility 177


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Procedure ABO HLAS HLAS1 Challenges per ShipmentABO grouping (includes A subtyping) ! 5HLA serologic typing (Class I and Class II) ! 3HLA serologic typing (Class I only) ! 3

Product InformationSurveys HLAS and HLAS1 are designed for laboratories performing HLA typing by serologic methods. Laboratoriesordering Survey HLAS will be able to report both Class I and Class II serologic results. Those laboratories that reportonly Class I types should order Survey HLAS1. Survey ABO may be ordered only in conjunction with either SurveyHLAS or HLAS1. Each shipment of Survey ABO will include five 2.0-mL specimens of 3% red blood cell suspensionand five 3.0-mL corresponding serum specimens. Each Survey HLAS shipment and each Survey HLAS1 shipment willcontain three suspensions of purified peripheral blood lymphocytes.

Product Fulfillment Group HL


Histocompatibility

HLA Serologic Typing (Class I/II) ABO, HLAS, HLAS1

178 Histocompatibility



Analyte/Procedure ABT ABT1 ABT2 Challenges per ShipmentAnti-A Titer ! ! 1Anti-D Titer ! ! 1

Product InformationSurvey ABT is designed for laboratories performing red cell antibody titers as a part of any of the following workups:a prenatal antibody quantification workup; the management of recipients of ABO incompatible bone marrowtransplants; determination of eligibility of O or B kidney transplant recipient candidates for receiving an A2 kidney;and/or assessment of the need and monitor the effect of plasma exchange in transplant recipients who are ABOincompatible with their donors.

Survey ABT1 is designed for laboratories performing titers for Anti-A.

Survey ABT2 is designed for laboratories performing titers for Anti-D.

Laboratories ordering Surveys ABT, ABT1, or ABT2 will be able to report using a variety of techniques.

Each shipment of Survey ABT will include one plasma specimen for anti-D titer, with one corresponding titer cell (3%red blood cell suspension) and one plasma specimen for anti-A titer with one corresponding titer cell (3% red bloodcell suspension). Each shipment of Survey ABT1 will include one plasma specimen for anti-A titer with onecorresponding titer cell (3% red blood cell suspension). Each shipment of Survey ABT2 will include one plasmaspecimen for anti-D titer, with one corresponding titer cell (3% red blood cell suspension).

Antibody Titer ABT, ABT1, ABT2



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Procedure B27 Challenges per ShipmentHLA-B27 typing ! 5

Product InformationSurvey B27 is designed for laboratories performing HLA-B27 typing by a variety of methods. Each shipment willinclude five whole blood specimens.

Procedure ML DL DML Challenges per ShipmentMolecular HLA-A, B, and C typing (Class I) ! ! 5Molecular HLA-DR, DQ, and DP typing (Class II) ! ! 5

Product InformationSurveys ML and DL are designed for laboratories performing HLA typing by molecular methods, such as clinicaltransplant laboratories and laboratories performing HLA disease-association tests. Note: Serological equivalentsmay also be reported.

Survey DML provides a convenient and cost-effective ordering option for laboratories conducting both Class I andClass II molecular typing. Each shipment will include five whole blood specimens in CPD or CPD-A.

HLA-B27 Typing B27

HLA Molecular Typing ML, DL, DML




Procedure MX1B MX1C MX1E Challenges per ShipmentCrossmatching ! ! 8Antibody screen ! ! ! 4Antibody identification ! ! ! 4

Product InformationThese Surveys are designed for laboratories performing HLA Class I crossmatching and/or antibody screening andspecificity identification. Specimen volumes in each of the Surveys vary, and participants should enroll in the Surveythat contains the volume that meets their testing requirements. For example, laboratories that perform testing only byserologic methods may want to order Survey MX1B. Laboratories that perform testing by flow cytometry, ELISA,or multiple methods may require larger volumes and may need to order Survey MX1C. Laboratories that requireadditional plasma for antibody screening/antibody specificity identification may want to subscribe to Survey MX1E.Note: Survey MX1E provides extra plasma only and must be ordered in conjunction with Survey MX1B or MX1C.Laboratories will be able to report results of multiple testing methods.

Each shipment of Survey MX1B will contain four 0.25-mL plasma specimens and two purified peripheral bloodlymphocyte specimens. Each Survey MX1C shipment will contain four 0.50-mL plasma specimens and twopurified peripheral blood lymphocyte specimens. Each Survey MX1E shipment will contain four 0.3-mL plasmaspecimens.

Product Fulfillment Group MX1

For laboratories conducting BOTH Class I and Class II HLA crossmatching,antibody screening, and antibody identification testing, refer to page 182 forSurveys MXB and MXC.

HLA Crossmatching, Antibody Screen, and AntibodyIdentification (Class I) MX1B, MX1C, MX1E



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For laboratories conducting BOTH Class I and Class II HLA crossmatching,antibody screening, and antibody identification testing, refer to page 182 forSurveys MXB and MXC.

Procedure MX2B MX2C MX2E Challenges per ShipmentCrossmatching ! ! 4Antibody screen ! ! ! 2Antibody identification ! ! ! 2

Product InformationSurveys MX2B, MX2C, and MX2E are designed for laboratories performing HLA Class II crossmatching and/orantibody screening and specificity identification. Specimen volumes in each of the Surveys vary, and participantsshould enroll in the Survey that contains the volume that meets their testing requirements. For example, laboratoriesthat perform testing only by serologic methods may want to order Survey MX2B. Laboratories that perform testing byflow cytometry, ELISA, or multiple methods may require larger volumes and may need to order Survey MX2C.Laboratories that require additional plasma for antibody screening/antibody specificity identification may want tosubscribe to Survey MX2E. Note: Survey MX2E provides extra plasma only and must be ordered in conjunctionwith Survey MX2B or MX2C. Laboratories will be able to report results of multiple testing methods.

Each shipment of Survey MX2B will contain two 0.25-mL plasma specimens and two purified peripheral bloodlymphocyte specimens. Each Survey MX2C shipment will contain two 0.5-mL plasma specimens and two purifiedperipheral blood lymphocyte specimens. Each Survey MX2E shipment will contain two 0.3-mL plasma specimens.

Product Fulfillment Group MX2

HLA Crossmatching, Antibody Screen, and AntibodyIdentification (Class II) MX2B, MX2C, MX2E




Procedure ME Challenges per ShipmentStem cell monitoring engraftment ! 3

Product InformationSurvey ME is designed for laboratories supporting stem cell transplant programs and laboratories monitoringchimerism after organ transplantation. This Survey will test the laboratory’s ability to effectively monitor allogeneicdonor cell engraftment or chimerism. Each shipment will include two whole blood specimens labeled “A” and “B”and three specimen mixtures of “A” and “B.”

Procedure Survey Code MXB MXCCrossmatching, antibody screen*, and antibody identification, Class I MX1B !

Crossmatching, antibody screen*, and antibody identification, Class II MX2B !

Crossmatching, antibody screen*, and antibody identification, Class I MX1C !

Crossmatching, antibody screen*, and antibody identification, Class II MX2C !

Product InformationCombination Surveys MXB and MXC allow your laboratory to receive Surveys MX1B/MX2B or MX1C/MX2C in oneorderable product. Surveys MX1E (Class I) and MX2E (Class II) provide extra plasma only and can be ordered withcombination Surveys MXB and MXC. Refer to pages 180 and 181 for more information on the specific Crossmatching,Antibody Screen, and Antibody Identification Surveys.

Specimen InformationRefer to the specific Surveys on pages 180 and 181 for specimen and analyte information.

*The analyte/challenge antibody screen is ungraded/educational in this Survey.

Monitoring Engraftment ME

HLA Crossmatching, Antibody Screen, and Antibody IdentificationClass I and Class II Combinations MXB, MXC

19GENETICS AND

MOLECULAR PATHOLOGY

Subdisc ip l ines

Cytogenetics......................................................................183

Biochemical and Molecular Genetics....................................187

Molecular Pathology ..........................................................189

Gene

tics

and

Mol

ecul

arPa

thol

ogy

Cytogenetics 183


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Analyte CY Challenges per ShipmentChromosome abnormality ! 5Karyotype ! 5Educational challenge, ungraded ! 1 per year

ACMG/CAP Cytogenetics CY

Product InformationSurvey CY is designed to provide educational opportunities for clinical cytogenetics laboratories. Participants arechallenged to identify and denote chromosomal abnormalities in G-banded chromosome preparations, using thecurrent International System for Human Cytogenetics Nomenclature (ISCN).

Survey challenges will include prints and digital images of metaphase cells. A total of five challenges will be includedwith each shipment. For each challenge, two copies each of at least three metaphase cells that are representative ofeach case will be included in the printed challenge. A brief case history will be included with each challenge.Challenges will vary with each Survey as follows:

• Two or three challenges will represent a constitutional chromosome disorder.

• Two or three challenges will illustrate a neoplastic disorder.

• CY-B will include an image of G-banded partial karyotypes from different cases. Participants are challenged toidentify whether the partial karyotypes are normal or abnormal and to identify the abnormalities noted.

• One shipment per year will include an educational challenge.

Each set of CYM ordered will consist of the same prints used in the Cytogenetics Survey CY.

For 2009, the CY Survey will continue to offer the traditional paper challenges to assist laboratories that have nottransitioned to online digital images.


Cytogenetics

CYTOGENETICS VALIDATED MATERIAL (CYM)

Beginning in 2009, CY grading will be modified to assess only chromosome abnormality and karyotype.Assessment of the modal chromosome number, sex chromosome designation, and karyotype nomenclature will beincorporated in the grade given for karyotype.

184 Cytogenetics



Product InformationSurvey CYF is designed for clinical laboratories that perform fluorescence in situ hybridization (FISH) using chromo-some-specific DNA probes for cell suspension samples (for FISH in paraffin-embedded tissue, see CYP). Participantswill use their own chromosome-specific DNA probes and FISH methodology to process and score a series ofmetaphase spreads and/or interphase nuclei for each specimen.

The first mailing will include one neoplastic disorder challenge (with two slides) for detection of chromosome 7monosomy or 7q deletion, one constitutional abnormality challenge (with two slides) for detection of a possiblecongenital abnormality involving the 22q11.2 critical region, and a photopage challenge representing a constitutionalabnormality.

The second mailing will consist of one challenge (with two slides) for detection of an MLL locus abnormality, onechallenge (with two slides) for detection of a congenital chromosome abnormality using probes that test foraneuploidy, and a color photograph challenge representing a neoplastic disorder.

Challenges per ShipmentProcedure CYF A BFISH for neoplastic disorder ! 1 2FISH for constitutional abnormality ! 2 1

ACMG/CAP Fluorescence In Situ Hybridization – Constitutionaland Hematologic Disorders CYF

Product InformationSurvey CYI will consist of two shipments of two cell samples suspended in ethanol from two different specimens.Participants are to use FISH to detect chromosomal abnormalities associated with urothelial carcinoma using probesfor the centromeres for chromosomes 3, 7, 17, and a locus-specific probe for 9p21.

Procedure CYI Challenges per ShipmentFISH for urothelial carcinoma ! 2

ACMG/CAP Fluorescence In Situ Hybridization –Urothelial Carcinoma CYI

Cytogenetics 185


www.cap.org

Product InformationSurvey CYH is designed for clinical laboratories that perform fluorescence in situ hybridization (FISH) usingchromosome-specific HER2 DNA probes. Participants will use their own chromosome-specific DNA probes andFISH methodology to process and score a series of interphase nuclei for each specimen.

Each mailing will consist of two five-core tissue microarray slides that offer a combined total of ten paraffin-embed-ded breast tissues specimens. A duplicate set of H&E stained tissue microarray slides will be provided with theshipment.

Procedure CYH Challenges per ShipmentHER2 gene amplification for breast cancer ! 10

ACMG/CAP Fluorescence In Situ Hybridization – Breast Cancer(HER2 Gene Amplification) CYH

Product InformationSurvey CYCGH is designed for clinical laboratories that perform genomic copy number assay by microarray analysisfor constitutional copy number changes. Extracted DNA will be provided for analysis using the same array platformand software analysis system used for clinical testing.

DNA will be obtained from individuals tested for a constitutional abnormality. Laboratories will assay specimens andinterpret results for potential abnormalities of copy number. Participants will be asked to identify and characterizegains or losses and the cytogenetic location of any abnormalities detected.

Procedure CYCGH Challenges per ShipmentMicroarray-genomic copy number assay for constitutional abnormality ! 2

ACMG/CAP Microarray-Genomic Copy Number Assay CYCGH(formerly Comparative Genomic Hybridization Microarray)

186 Cytogenetics



Challengesper Shipment

Gene/Region of Interest CYJ CYK CYL(Glioma tissue) (Sarcoma tissue or (Lymphoma tissue) A B

pediatric neoplasm)1p/19q ! 1 1EWSR1 ! 1IGH/BCL2 ! 1SS18 (SYT) ! 1CCDN1/IGH ! 1

Product InformationThese Surveys are designed for clinical laboratories that perform fluorescence in situ hybridization (FISH) usingchromosome-specific DNA probes in paraffin-embedded tissue (see CYF for FISH in cell suspension specimens).Participants will use their own chromosome-specific DNA probes and FISH methodology to process and score aseries of interphase nuclei for each specimen. All specimens will be 4-micron tissue sections mounted on positivelycharged glass slides. One hematoxylin-eosin stained slide will also be provided with each challenge for reference.

The first mailing (CYP-A) will include one challenge each for CYJ, CYK, and CYL. CYJ-A will consist of four unstainedslides from paraffin-embedded tissue representing a neurological cancer specimen (glioma). Participants are to useFISH probes for detection of deletions within 1p36 and 19q13 band regions. CYK-A will consist of two unstainedslides from paraffin-embedded tissue representing a pediatric neoplasm. Participants are to use FISH probes to detectaberrations of the EWSR1 gene (22q12). CYL-A will consist of two unstained slides from paraffin-embedded tissuerepresenting a lymphoma specimen. Participants are to use FISH probes to detect rearrangement of the IGH/BCL2genes (14q32/18q21).

The second mailing (CYP-B) will include one challenge each for CYJ, CYK and CYL. CYJ-B will consist of fourunstained slides from paraffin-embedded tissue representing a neurological cancer specimen (glioma). Participantsare to use FISH probes for detection of deletions within 1p36 and 19q13 band regions. CYK-B will consist of twounstained slides from paraffin-embedded tissue representing a sarcoma tissue. Participants are to use FISH probes todetect aberrations of the SS18 (SYT) gene (18q11.2). CYL-B will consist of two unstained slides from paraffin-embedded tissue representing a lymphoma specimen. Participants are to use FISH probes to detect rearrangement ofthe CCDN1/IGH genes (11q13/14q32).

Product Fulfillment Group CYP

ACMG/CAP FISH For Paraffin-Embedded Tissue – CYJ, CYK, CYL

Biochemical and Molecular Genetics 187


www.cap.org

Analyte/Procedure BGL Challenges per ShipmentAcylcarnitine (qualitative and quantitative) ! 1Amino acids (qualitative and quantitative) ! 1Mucopolysaccharides (qualitative) ! 1Organic acids (qualitative and quantitative) ! 1Educational specified metabolic disorder ! 1

Product InformationSurvey BGL is designed for laboratories specializing in the biochemical testing of metabolic diseases. Foracylcarnitine testing, a plasma specimen (approximately 100 lambda) will be provided. A 5.0 to 10.0-mL urinespecimen will be provided for mucopolysaccharides and organic acids testing. For amino acid testing, either aplasma (up to 1.0-mL) or urine specimen (5.0 to 10.0-mL) will be provided. The last specimen will be provided fora specified group of metabolic disorders and will include plasma, urine, or other appropriate material.

Biochemical and Molecular GeneticsAnalytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS).

ACMG/CAP Biochemical Genetics BGL

Product InformationSurvey PGx is designed for laboratories performing genetic testing for predicting drug response. Each sample willinclude 25µg of extracted DNA. Interpretive challenges will also be included in the context of the clinical casescenario. Participants may perform testing for CYP2C19, CYP2C9, CYP2D6, UGT1A1, and VKORC1 on each sample.

Analyte/Procedure PGx Challenges per ShipmentAllele detection ! 2

Pharmacogenetics PGx

188 Biochemical and Molecular Genetics



Disease/Gene MGL1 MGL2 MGL3 MGL4 MGL5BRCA1/2 !

Canavan !

Connexin-26 !

Cystic fibrosis ! !

DMD/Becker !

Factor V Leiden !

Familial dysautonomia !

Fragile X !

Friedreich ataxia !

Hemochromatosis !

Hemoglobin S/C !

Huntington disease !

Methylenetetrahydrofolate reductase (MTHFR) !

Multiple endocrine neoplasia type 2 (MEN2) !

Myotonic dystrophy !

Prader-Willi/Angelman Syndrome !

Prothrombin !

RhD !

Spinal muscular atrophy !

Spinocerebellar ataxia !

Tay Sachs !

Product InformationSurveys MGL1, MGL2, MGL3, MGL4, and MGL5 are designed for laboratories specializing in molecular testingfor genetic disease. Each disease/gene will have three challenges per shipment with the exception of MGL5, whichwill have two challenges per shipment. Each shipment will include approximately 50 µg of extracted DNA.

Product Fulfillment Group MGL

ACMG/CAP Molecular GeneticsMGL1, MGL2, MGL3, MGL4, MGL5

Molecular Pathology 189


www.cap.org

Molecular PathologyAnalytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS).

Procedure MO MO2 MO3 Challenges per ShipmentMolecular analysis (cells, frozen tissue, or DNA) ! 2Molecular analysis, double volume(cells, frozen tissue, or DNA) ! 2Molecular analysis (paraffin sections) ! 2

Product InformationSurvey MO is designed for laboratories performing molecular analysis of leukemias and lymphomas. Survey MO2contains additional sample vials to accommodate laboratories performing RNA testing in addition to DNA testing.Survey MO3 is for laboratories performing molecular analysis of leukemias and lymphomas on paraffin sections.Note: Laboratories performing immunophenotyping on patients with leukemia and/or lymphoma should referto Survey FL3 on page 159 and Survey MK on page 197.

Each shipment of Survey MO will include two sample vials containing a snap frozen cell pellet, frozen tissuespecimen, or DNA. From each pellet or frozen tissue specimen, at least 100 µg of DNA can be extracted forSouthern blot analysis and/or amplification of antigen receptor (B- and T-cell) gene arrangement or selected(B- and T-cell) translocations (eg, bcr). Survey MO2 will contain four sample vials (two per specimen). Eachshipment of Survey MO3 will contain four 10-micron paraffin sections per specimen.

Product Fulfillment Group MO

Molecular Oncology MO, MO2, MO3

190 Molecular Pathology



Procedure ISH Challenges per ShipmentEpstein-Barr virus ! 1Human papillomavirus ! 1Kappa lambda ! 1

Product InformationSurvey ISH offers laboratories performing clinical in situ hybridization tests the opportunity to objectively evaluatetheir performance for targets including human papillomavirus (HPV), Epstein-Barr virus (EBV), and Kappa lambda.Information including the conditions of slide pretreatment, probe type, hybridization conditions, and detectionsystems will be used to facilitate interlaboratory comparison of methods and standardization. Laboratoriesperforming FISH for interphase chromosomal targets in paraffin sections should refer to CY Surveys.

Each shipment for in situ hybridization analysis will include tissue microarray sides for each HPV, EBV, and Kappalambda.

Product Fulfillment Group ISH

In Situ Hybridization ISH

Note: Brightfield in situ hybridization for HER2 is now offered in ISH2.

Product InformationSurvey ISH2 is designed for clinical laboratories that perform brightfield in situ hybridization (ISH) for HER2.

Each mailing will consist of two sets of five-core tissue microarray slides that offer a combined total of ten uniqueparaffin-embedded breast tissue specimens. Laboratories performing FISH for interphase chromosomal targets inparaffin sections should refer to CY Surveys.


Procedure ISH2 Challenges per ShipmentHER2 gene amplification for breast cancer ! 10

In Situ Hybridization, HER2 ISH2

Molecular Pathology 191


www.cap.org800-323-4040 Option 1 for Customer Contact Center

Product InformationSurvey SARC is designed for laboratories performing molecular analysis of sarcoma translocations by RT-PCR. Theparticipants may perform testing on the sample for any sarcoma translocation, including EWS/EGR, t(21;22);EWS/FL11, t(11;22); EWS/WT1, t(11;22); FUS/CHOP, t(12;16); PAX3/FKHR, t(2,13); PAX7/FKHR, t(1;13);PDGFB/COL1A1, t(17;22); SYT/SSX1, t(X;18); SYT/SSX2, t(X;18); and SYT/SSX, NOS.

Each shipment of Survey SARC will include one snap frozen cell pellet or extracted RNA from which the participantwill be able to extract approximately 5 to 10 micrograms of RNA.

Analyte SARC Challenges per ShipmentSarcoma translocation ! 1

Product InformationSurvey MSI is designed for laboratories performing microsatellite analysis of paraffin-embedded colorectal carcinoma(or other HNPCC-related tumors) by DNA amplification.

Each shipment will include one H&E slide and two or more 10-micron unstained sections on glass slides to be usedto isolate DNA from tumor and normal tissue for microsatellite instability analysis.

Analyte MSI Challenges per ShipmentMicrosatellite instability (paraffin sections) ! 1

Sarcoma Translocation SARC

Microsatellite Instability MSI

Product InformationSurvey MRD is designed for laboratories that perform minimal residual disease testing in cancer patients. The Surveyis specifically designed for laboratories monitoring chronic myelogenous leukemia by measuring the quantity ofBCR/ABL1 transcripts at diagnosis and during or after therapy.

Each shipment of Survey MRD will arrive packed in dry ice and include three sample vials each holding RNA inethanol.

Analyte MRD Challenges per ShipmentMinimal residual disease ! 3

Minimal Residual Disease MRD

20ANATOMIC PATHOLOGY

New for 2009! Progesterone Receptor (PR) Tissue Microarray Survey (PM2)

! Online Digital Slide Program in Dermatopathology (DPATH, DPATH1)

Anat

omic

Path

olog

y

Subdisc ip l ines

Surgical Pathology ............................................................193

General Immunohistochemistry ............................................197

Predictive Markers..............................................................198

Cytopathology ..................................................................200

Specialty Anatomic Pathology..............................................205

Cytogenetics and Molecular Pathology ................................207

Surgical Pathology 193


www.cap.org

Program PIP Challenges per ShipmentSurgical pathology case review for one pathologist ! 10

Product InformationThe Performance Improvement Program in Surgical Pathology (PIP) is designed by pathologists for the education ofpathologists in general surgical pathology. This program provides a practical approach to continuing education insurgical pathology and gives pathologists a method to assess their diagnostic skills and compare their performancewith that of their peers.

Each quarterly shipment will contain ten unknown cases with patient histories. PIP case selections represent a varietyof neoplastic and non-neoplastic lesions, including inflammatory and infectious diseases, and will be made fromvarious sites, encompassing essentially all organ sites.

The participant selects the appropriate diagnosis from a master list provided with each case. Also included in eachmailing is a review of the case features with diagnostic highlights and educational questions. Participants are asked toreturn to the CAP the completed questionnaire with their diagnoses and answers to the educational questions. Inreturn a certificate for CME credit is mailed to the pathologist, and a report tabulated with peer group responses willfollow. The slides become the property of the PIP subscribers.

PIP is designed for educational purposes only. The program is unsuitable for proficiency testing or grading becauseof the large number of blocks used for each case and their inherent variability and because rare or newly describedlesions are often included.

Pathologists can earn a maximum of 40 CME credits (AMA PRA Category 1 Credits™) per pathologist for completionof an entire year (see Chapter 3, Continuing Education). For those institutions with multiple pathologists interested inparticipating in PIP and obtaining their own CME credits, the PIP1 option is available.

Product Fulfillment Group PIP

Surgical Pathology

CME

www.cap.org

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Earn

Note: The PIP1 Program must be ordered only in conjunction with PIP.


Performance Improvement Programin Surgical Pathology PIP (PIP1)

Surgical Pathology Option: PIP1 (For each additional pathologist within the same institution)

194 Surgical Pathology



Program VBP Challenges per ShipmentOnline virtual biopsy case review ! 5

Product InformationThe Online Virtual Biopsy Program (VBP) is designed as an educational program for participants to assess andimprove their diagnostic skills in surgical pathology. Using digital image technology to simulate the use of a micro-scope in evaluating slides enables the use of a wide variety of case materials and provides all participants with identi-cal diagnostic challenges. This VBP is designed as an educational activity and is not designed for proficiency testing.

Four online activities will be available in 2009, each containing five diagnostic challenges. Each challenge willconsist of one or more digital images derived from a single case, plus clinical history and other pertinentinformation. Participants will be able to manipulate the digital slide images by scanning throughout the slide fieldand changing the magnification. Some cases may also include gross, radiographic, or endoscopic images.Participants will receive immediate feedback as they select diagnoses and answer educational questions.

Case selections will be made from selected organ systems and may include a variety of specimen types (eg, corebiopsies, endoscopic biopsies, curettings, aspirate smears). The 2009 online VBP activities will focus on thefollowing organ sites:

Activity Course2009-A Lung biopsy2009-B Gastrointestinal biopsy2009-C Breast biopsy2009-D Surgical pathology biopsy

Pathologists can earn a maximum of 10 CME credits (AMA PRA Category 1 Credits™) for completion of an entireyear. For those institutions with multiple pathologists interested in participating and obtaining their own CME credits,the VBP1 option is available.

For information on computer requirements and continuing medical education, please see Chapter 3, ContinuingEducation.

Participants will be notified by mail when each online activity is available.

Product Fulfillment Group VBP

CME

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Online Virtual Biopsy Program VBP, VBP1

Online Virtual Biopsy Program Option: VBP1 (For each additional pathologist within the same institution)Note: The VBP1 must be ordered only in conjunction with VBP.

Surgical Pathology 195


www.cap.org

Product InformationThe Online Digital Slide Program in Dermatopathology Program (DPATH) is designed as an educational program forpathologists and dermatologists to assess and improve their diagnostic skills in Dermatopathology. Using onlinewhole slide imaging (WSI) technology to simulate the use of a microscope in evaluating slides enables the use of awide variety of case materials and provides all participants with identical diagnostic challenges. This program isdesigned as an educational program and not designed for proficiency testing.

Two online activities will be available in 2009 containing five diagnostic challenges. Each challenge will consist ofclinical information along with one or more whole slide images (WSI) derived from a single case. Participants will beable to manipulate the WSI by scanning throughout the field and changing magnification. Some cases may alsoinclude additional clinical or microscopic images.

This program is designed for individual pathologists and dermatologists who can earn a maximum of 5.0 CMEcredits (AMA PRA Category 1 Credits ™) for the completion of an entire year. For those institutions with multiplepathologists and/or dermatologists interested in participating and obtaining their own CME credits, the DPATH1option is available.



Product Fulfillment Group DPATH

Program DPATH Challenges per ShipmentOnline digital slide dermatopathology case review ! 5

CME

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Online Digital Slide Program in DermatopathologyDPATH (DPATH1)

Online Digital Slide Program in DPATH Option: DPATH1(For each additional pathologist within the same institution)

Note: The DPATH1 Program may be ordered only in conjunction with DPATH.

196 Surgical Pathology



Challenges per ShipmentStain/Tissue HQIP A BH&E – Prostate needle biopsy ! 1H&E – Brain (Cerebellum) ! 1Gram Stain (positive and negative on slide) ! 1Luxol fast-blue (Cerebellum) ! 1P63 – Prostate needle biopsy ! 1H&E – Skin (Punch biopsy) ! 1H&E – Lung (wedge or resection specimen) ! 1PAS – Liver core biopsy ! 1PAS-D – Liver core biopsy ! 1TTF1 – Lung adenocarcinoma ! 1

Product InformationThe HistoQIP Program is designed as an educational program to improve the preparation of histologic slides.Participants will receive an evaluation specific to their laboratory, an educational critique, and a participant summaryreport that includes peer comparison data, evaluators’ comments, and performance benchmarking data.

Twice each year, participating laboratories will submit one stained and coverslipped glass slide from five differentcases (two H&E-stained slides, two special stains, and one immunohistochemical stain). All submitted slides will berecuts of specific surgical tissue types or positive control tissue that will vary from one challenge to the next.Submitted slides will be evaluated for histologic technique by an expert panel of histotechnologists, histotechnicians,and pathologists, using uniform grading criteria. The following areas will be evaluated: fixation, tissue processing andembedding, microtomy, staining, and coverslipping.

This Survey provides an education activity that includes reading material found in the Final Critique and onlinelearning assessment questions. All laboratory staff can participate individually and earn free CE credit without leavingthe laboratory.

CE

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NSH/CAP HistoQIP HQIP

General Immunohistochemistry 197


www.cap.org

Procedure MK Challenges per ShipmentImmunohistochemistry ! 4

Product InformationSurvey MK is designed as a proficiency testing program for laboratories performing immunohistochemistry proce-dures. Each shipment contains glass slides with unstained tissue sections from four separate cases. Participants areinstructed to stain the slides for specified antigens and report the results; additional slides are provided for an H&Estain and negative controls.

Product Fulfillment Group MK

General ImmunohistochemistryAnalytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS).

Immunohistochemistry MK

Note: MK1 is no longer offered.

198 Predictive Markers



Predictive MarkersAnalytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS).

Product InformationSurvey HER2 is a proficiency testing program for laboratories that interpret and report the results of HER2 byimmunohistochemistry. The program is designed to fulfill the proficiency testing requirement in the CAP/ASCO HER2Testing Guidelines. Each shipment contains 10-core tissue microarray slides and image challenges. Participants areinstructed to stain the slide using their routine HER2 procedures and report the results of each core.

Due to the unique nature of these materials that are human donor based, the shipping date is subject to change. Ifthis should occur, a notification will be provided prior to the originally scheduled date.

Analyte HER2 Challenges per ShipmentHER2 ! Variable

HER2 Immunohistochemistry HER2

Predictive Markers 199


www.cap.org

Product InformationSurveys PM1, PM2, PM3, and PM4 are designed for laboratories performing immunohistochemistry procedures forpredictive markers. Participants are asked to stain one ten-core tissue microarray slide for the assigned “marker”using immunohistochemistry procedures and provide interpretation. There will be two annual shipments for PM2.Each PM2 shipment will contain two 10-core microarray slides, one for ER and one for PR.

Analyte PM1 PM2 PM3 PM4 Challenges per ShipmentCD117 ! 10Estrogen Receptor (ER) ! 10Progesterone Receptor (PR) ! 10CD20 ! 10Epidermal Growth Factor Receptor (EGFR) ! 10

CD117, ER, CD20, EGFR Immunohistochemistry, Tissue MicroarrayPM1, PM2, PM3, PM4

200 Cytopathology



CytopathologyAnalytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS).

Product InformationPAP PT includes two components: a CMS-approved Cytology Proficiency Testing (PT) Program and an educationalInterlaboratory Comparison Program in Gynecologic Cytopathology (PAP Education).

The PAP PT Program mailing will occur on one of 23 test sessions based on participant preference and slidesetavailability. Successful completion of the Program satisfies an individual’s 2009 cytology PT requirement per CLIA.

Participation in the two education mailings (PAP Education) meets the CAP Laboratory Accreditation Programrequirement for participation in a peer educational program. Each of the two education mailings will include fiveglass slides. Reference interpretations and laboratory performance profiles for the five glass slides are availablewithin 20 minutes by fax, providing rapid educational feedback, peer comparison, and time to further reviewthe material before returning the slides to the CAP. Laboratories may choose either Education Series 1 or EducationSeries 2 ship dates.

Each education mailing will also contain instructions to access two online virtual microscopy cases (four per year),which use digital image technology to simulate the use of a microscope. Online images will consist of diagnosticchallenges incorporating Bethesda terminology. Participants will be able to manipulate the images by scanning acrossthe slide, changing the magnification, and focusing on areas of interest. Participants will receive immediate feedbackas they select interpretations, make recommendations for follow-up, and answer case-related educational questions.

Pathologists can earn a maximum of 10 CME credits (AMA PRA Category 1 Credits™) and cytotechnologists can earna maximum of 10 CE credits/hours for completion of an entire year: eight credits for PAP Education glass slide reviewand two credits for online case review (see Chapter 3).

Slidesets must be returned by a trackable method within the time period stated in the kit instructions.Laboratories not returning their slides on time will forfeit subsequent shipments and may be ineligible to enroll infuture cytopathology programs.

PT Event Date Choices: see shipping calendar at the end of catalog.

CMS APPROVED CYTOLOGY PROFICIENCY TESTING PROGRAM

Challenges per ShipmentProficiency Education Education

Procedure PAPCPT PAPKPT* PAPMPT* PAPJPT PPTENR Testing A BConventional ! ! 5 slides + 2 onlineThinPrep® ! ! 5 slides + 2 onlineSurePath™ ! !

PAP PT Laboratory Enrollment !

* The PAPKPT and PAPMPT slidesets will contain ten liquid-based slides only.The PAP PT Laboratory Enrollment Only is designed for laboratories that possess a CLIA license to perform gynecologic cytologybut have personnel that are testing at another location. The laboratory must be enrolled in a PT program in order to becompliant with CLIA ’88, even though personnel are not testing at that location.

10 slides5 slides +2 online

cases

5 slides +2 online

cases

CME/CE

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Gynecologic Cytology PT Program (with PAP Education) PAP PT

Order APAPCPT, APAPKPT, APAPMPT, or APAPJPT for each pathologist/cytotechnologist on the same testing date within a facility.

Cytopathology 201


www.cap.org

Product InformationThe Interlaboratory Comparison Program in Gynecologic Cytopathology (PAP Education) is designed as a peereducational opportunity for participants to assess their screening and interpretive skills. Each semi-annual shipmentwill include five ungraded specimens on glass slides with patient histories. For PAPCE1, the ungraded slides will beconventional preparations. PAPKE1 will be all SurePath™ preparations and PAPME1 will be all ThinPrep® prepara-tions. For PAPJE1, the slidesets will be a combination of conventional, ThinPrep®, and SurePath™ slides. Referenceinterpretations and laboratory performance profiles are available within 20 minutes by fax, providing rapideducational feedback, peer comparison, and time to further review the material before returning the slides to theCAP.

Each shipment will also contain instructions to access two online virtual microscopy cases (four per year), which usedigital image technology to simulate the use of a microscope. Online images will present diagnostic challengesincorporating Bethesda terminology. Participants will be able to manipulate the images by scanning across the slide,changing the magnification and focusing on areas of interest. Participants will receive immediate feedback as theyselect interpretations, make recommendations for follow-up, and answer case-related educational questions.

Pathologists can earn a maximum of 10 CME credits (AMA PRA Category 1 Credits™) and cytotechnologists can earna maximum of 10 CE credits/hours for completion of an entire year: eight credits for glass slide review and twocredits for online case review (see Chapter 3).

The PAP Education base program includes one laboratory response form. For each pathologist or cytotechnologist toparticipate in the 10-case glass slide portion of the PAP Education Program and obtain his/her own credits/hours, anAPAP option (APAPCE1/APAPKE1/APAPME1/APAPJE1) should be ordered. The four online cases may be accessed andcompleted for two CME/CE credits by all staff in a participating institution independent of the number of APAP optionsordered.


Product Fulfillment Group PAPC/J/K/MED1

Procedure PAPCE1 PAPKE1PAPME1 PAPJE1 Challenges per ShipmentEach module includes the following slide types:

Conventional ! ! 5 slides + 2 online casesThinPrep® ! ! 5 slides + 2 online casesSurePath™ ! ! 5 slides + 2 online cases

CME/CE

www.cap.org

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The PAP Education program meets the CAP Laboratory Accreditation Program requirements for participation in a peereducational program for international laboratories, non-CLIA laboratories, and laboratories that are not participating in CAPPAP PT. CLIA laboratories should enroll in one of the PAP PT programs, which include PAP Education (see page 200).

PAP Education-Interlaboratory Comparison Program inGynecologic Cytopathology PAPCE1, PAPKE1, PAPME1, PAPJE1

Order APAPCE1, APAPKE1, APAPME1, or APAPJE1 for each pathologist/cytotechnologist within the same facility.

202 Cytopathology



Product InformationThe Interlaboratory Comparison Program in Non-Gynecologic Cytopathology (NGC) is designed as an educationalopportunity for participants to assess their screening and interpretive skills. Because NGC cases are chosen for theireducational value, the NGC Program is unsuitable for proficiency testing.

Each quarterly shipment will include five specimens on glass slides with patient histories. Cases include fine needleaspirations and exfoliative specimens representing a variety of conditions, both benign and malignant. Referenceinterpretations and laboratory peer performance, along with concise cytologic features and pertinent references, areavailable within 20 minutes by fax, providing rapid educational feedback, peer comparison, and time to furtherreview the material before returning the slides to the CAP.

NGC Shipments will contain instructions for accessing online two virtual microscopy cases (four per year), which usedigital image technology to simulate the use of a microscope. Online images will consist of rare and unusual non-gynecologic cases with ancillary information when case appropriate. Participants will be able to manipulate theimages by scanning across the slide, changing the magnification and focusing where appropriate. Participants willreceive immediate feedback as they select interpretations from a master list and answer educational questions.

Pathologists can earn a maximum of 18 CME credits (AMA PRA Category 1 Credits™) and cytotechnologists can earna maximum of 18 CE credits/hours for completion of an entire year: 16 credits for glass slide review and two creditsfor online case review (see Chapter 3, Continuing Education).

The NGC Program includes a laboratory response and two individual response forms. For institutions with multiplepathologists or cytotechnologists interested in participating in the glass slide portion of the NGC Program andobtaining his/her own credits/hours, the NGC1 option is available. The four online cases may be accessed andcompleted for two CME/CE credits by all staff in a participating institution independent of the number of NGC1options ordered.


Product Fulfillment Group NGC

Program NGC Challenges per ShipmentNon-gynecologic cytopathology case review—glass slides ! 5Non-gynecologic cytopathology case review—online ! 4 per year

CME/CE

www.cap.org

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Earn

Note: The NGC1 Program may be ordered only in conjunction with NGC.

Interlaboratory Comparison Program inNon-Gynecologic Cytopathology NGC (NGC1)

CNGC includes one Laboratory response and two additional individual participants – pathologists or cytotechnologistsCytopathology Options: NGC1 (For each additional pathologist or cytotechnologist within the same institution)

Cytopathology 203


www.cap.org

Product InformationThe Online Digital Slide Program in Fine-Needle Aspiration (FNA) is an educational program for pathologists, resi-dents, and experienced cytotechnologists to assess and improve their diagnostic skills in non-gynecologic fine needleaspirations. Using digital image technology to simulate the use of a microscope in evaluating slides enables the use ofa wide variety of case materials and provides all participants with identical diagnostic challenges. This FNA programwill focus on diagnostic dilemmas encountered by pathologists in practice and is designed as an educational activity.It is not suitable for proficiency testing.

Two online activities will be available, each activity containing five diagnostic challenges. Each challenge will consistof one or more digital images derived from a single case, plus clinical history and other pertinent information.Participants will be able to manipulate the digital slide images and will receive immediate feedback as they selectinterpretations from a master list and answer educational questions. Selections of ancillary studies such as immuno-histochemical stains, molecular tests, and/or flow cytometry will be available as case appropriate. Topics for 2009will include thyroid and pancreas body sites.

Pathologists can earn a maximum of 5 CME credits (AMA PRA Category 1 Credits™) and cytotechnologists can earn amaximum of 5 CE credits/hours for completion of an entire year. For those institutions with multiple pathologistsand/or cytotechnologists interested in participating and obtaining their own CME/CE credits, the FNA1 option isavailable.



Product Fulfillment Group FNA

Program FNA Challenges per ShipmentOnline digital slide fine-needle aspiration case review ! 5

Online Digital Slide Program in Fine-Needle AspirationFNA (FNA1)

Online Digital Slide Program in FNA Option: FNA1 (For each additional pathologist within the same institution)Note: The FNA1 Program may be ordered only in conjunction with FNA.

CME/CE

www.cap.org

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204 Cytopathology



Product InformationSurveys CHPVD, CHPVM, CHPVK, and CHPVJ are designed for laboratories performing nucleic acid amplification forhigh risk HPV. Each shipment includes simulated cervical specimens.

The laboratory should choose the module that best reflects the transport medium(s) in its facility. Over the course ofthree shipments, subscribers to the CHPVJ will receive five specimens of all three medium types.

Survey CHPVD Digene® Specimen Transport Medium™ (STM)Survey CHPVM ThinPrep® PreservCyt® transport MediumSurvey CHPVK SurePath™ Preservative Fluid transport mediumSurvey CHPVJ Combination pack includes Digene®, ThinPrep® PreservCyt®, and SurePath™ transport medium

Product Fulfillment Group CHPV

Analyte CHPVD CHPVM CHPVK CHPVJ Challenges per ShipmentHPV ! ! ! ! 5

Human Papillomavirus (High Risk) for CytologyCHPVD, CHPVM, CHPVK, CHPVJ

Note: These Surveys are intended for laboratories that test material from PAP vials for HPV. Each product will meet regulatoryrequirements for viral identification.

Specialty Anatomic Pathology 205


www.cap.org

Program NP Challenges per ShipmentNeuropathology case review ! 8

Product InformationThe Neuropathology Program is designed as an educational program for anatomic pathologists, neuropathologists,and trainees to assess and improve their diagnostic skills and to learn of new developments in neuropathology.

Each shipment contains a CD-ROM with eight cases that cover the spectrum of neoplastic and non-neoplasticdisorders affecting the central and peripheral nervous systems, including infectious, degenerative, developmental,demyelinating, traumatic, toxic-metabolic, vascular, and neuromuscular diseases. Four of the eight cases in eachshipment comprise a mini-symposium focused on a specific problem area in neuropathology. The other four casescover a variety of nervous system diseases.

For each case, pertinent clinical and laboratory information and several microscopic images are provided. Somecases also include radiographic and/or gross images. Following review of the case materials, participants answer aseries of questions directed at diagnosis, interpretation, and pathophysiology.

All participants receive on the CD-ROM a critique including diagnosis, focused discussion and review, and selectedreferences for each case. Participants can also download case materials from the CD-ROM for educational purposes.The NP cases are selected for their educational value; the case selection and evaluation process make the programunsuitable for proficiency testing or grading.

Pathologists can earn a maximum of eight CME credits (AMA PRA Category 1 Credits™) for completion of an entireyear (see Chapter 3, Continuing Education). For those institutions with multiple pathologists interested in participat-ing and obtaining their own CME credits, the NP1 option is available. Survey NP1 will include only a result form andCME form for an additional pathologist within the same institution.

Product Fulfillment Group NP

Specialty Anatomic Pathology

CME

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Note: The NP1 Program may be ordered only in conjunction with NP.


Neuropathology Option: NP1 (For each additional pathologist within the same institution)

Neuropathology Program NP (NP1)

206 Specialty Anatomic Pathology



Product InformationParticipants in the program will receive detailed discussions of challenging autopsy cases. Each shipment of SurveyAU will include six cases, each consisting of a case description and illustrative 35mm gross and/or microscopicslides, with questions directed at aspects of interpretive analysis, differential diagnosis, pathophysiology, cause ofdeath, and quality assurance. In addition, each case will include a PowerPoint summary slide highlighting the keyteaching points of each case. Survey AU1 will include only a Result Form and CME form for an additional pathologistwithin the same institution. To provide participants with immediate feedback, detailed discussions with currentreferences will be included in the original mailing.

Each shipment of Survey AUCD will include the same six cases as above, but instead of 35mm slides, the images willbe provided on a CD-ROM. Survey AUCD1 will include only a Result Form and CME form for an additional pathologistwithin the same institution. To provide participants with immediate feedback, detailed discussions with current refer-ences will be included in the original mailing.

Pathologists can earn a maximum of 12 CME credits (AMA PRA Category 1 Credits™) for completion of an entireyear (see Chapter 3, Continuing Education). For those institutions with multiple pathologists interested in participat-ing and obtaining CME credit, the AU1 and AUCD1 options are available. Surveys AU and AUCD are designed foreducational purposes and are not suitable for proficiency testing.

Program AU AUCD Challenges per ShipmentAutopsy case analysis ! 6Autopsy case analysis (CD-ROM) ! 6

CME

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Earn

Note: The AU1 Program may be ordered only in conjunction with Survey AU. The AUCD1 Program may be orderedonly in conjunction with Survey AUCD.

Discover This Unique PublicationAn Introduction to Autopsy Technique, 2nd EditionKim A. Collins, MD, and Grover M. Hutchins, MD, editors

The 2nd edition of this “how-to” manual depicts both general and specialized techniques forperforming autopsies in postmortem examinations in a hospital setting. Two-volume set, softcoverplus laminated diagrams.

Autopsy Pathology AU (AU1), AUCD (AUCD1)

Autopsy Pathology Option:AU1 (For each additional pathologist within the same institution)

Autopsy Pathology CD-ROM Option:AUCD1 (For each additional pathologist within the same institution)

Cytogenetics and Molecular Pathology 207


www.cap.org

Product InformationSurvey CYH is designed for clinical laboratories that perform fluorescence in situ hybridization (FISH) usingchromosome-specific HER2 DNA probes. Participants will use their own chromosome-specific DNA probes andFISH methodology to process and score a series of interphase nuclei for each specimen.

Each mailing will consist of two five-core tissue microarray slides that offer a combined total of ten paraffin-embed-ded breast tissues specimens. A duplicate set of H&E stained tissue microarray slides will be provided with theshipment.

Procedure CYH Challenges per ShipmentHER2 gene amplification for breast cancer ! 10

Cytogenetics and Molecular PathologyAnalytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS).

ACMG/CAP Fluorescence In Situ Hybridization – Breast Cancer(HER2 Gene Amplification) CYH

208 Cytogenetics and Molecular Pathology



Challengesper Shipment

Gene/Region of Interest CYJ CYK CYL(Glioma tissue) (Sarcoma tissue or (Lymphoma tissue) A B

pediatric neoplasm)1p/19q ! 1 1EWSR1 ! 1IGH/BCL2 ! 1SS18 (SYT) ! 1CCDN1/IGH ! 1

Product InformationThese Surveys are designed for clinical laboratories that perform fluorescence in situ hybridization (FISH) usingchromosome-specific DNA probes in paraffin-embedded tissue (see CYF for FISH in cell suspension specimens).Participants will use their own chromosome-specific DNA probes and FISH methodology to process and score aseries of interphase nuclei for each specimen. All specimens will be 4-micron tissue sections mounted on positivelycharged glass slides. One hematoxylin-eosin stained slide will also be provided with each challenge for reference.

The first mailing (CYP-A) will include one challenge each for CYJ, CYK, and CYL. CYJ-A will consist of four unstainedslides from paraffin-embedded tissue representing a neurological cancer specimen (glioma). Participants are to useFISH probes for detection of deletions within 1p36 and 19q13 band regions. CYK-A will consist of two unstainedslides from paraffin-embedded tissue representing a pediatric neoplasm. Participants are to use FISH probes to detectaberrations of the EWSR1 gene (22q12). CYL-A will consist of two unstained slides from paraffin-embedded tissuerepresenting a lymphoma specimen. Participants are to use FISH probes to detect rearrangement of the IGH/BCL2genes (14q32/18q21).

The second mailing (CYP-B) will include one challenge each for CYJ, CYK and CYL. CYJ-B will consist of fourunstained slides from paraffin-embedded tissue representing a neurological cancer specimen (glioma). Participantsare to use FISH probes for detection of deletions within 1p36 and 19q13 band regions. CYK-B will consist of twounstained slides from paraffin-embedded tissue representing a sarcoma tissue. Participants are to use FISH probes todetect aberrations of the SS18 (SYT) gene (18q11.2). CYL-B will consist of two unstained slides from paraffin-embedded tissue representing a lymphoma specimen. Participants are to use FISH probes to detect rearrangement ofthe CCDN1/IGH genes (11q13/14q32).

Product Fulfillment Group CYP

ACMG/CAP FISH For Paraffin-Embedded Tissue – CYJ, CYK, CYL



www.cap.org

Procedure ISH Challenges per ShipmentEpstein-Barr virus ! 1Human papillomavirus ! 1Kappa lambda ! 1

Product InformationSurvey ISH offers laboratories performing clinical in situ hybridization tests the opportunity to objectively evaluatetheir performance for targets including human papillomavirus (HPV), Epstein-Barr virus (EBV), and Kappa lambda.Information including the conditions of slide pretreatment, probe type, hybridization conditions, and detectionsystems will be used to facilitate interlaboratory comparison of methods and standardization. Laboratoriesperforming FISH for interphase chromosomal targets in paraffin sections should refer to CY Surveys.

Each shipment for in situ hybridization analysis will include tissue microarray slides, for each HPV, EBV, and Kappalambda.


In Situ Hybridization ISH

Note: Brightfield in situ hybridization for HER2 is now offered in ISH2.

Product InformationSurvey ISH2 is designed for clinical laboratories that perform brightfield in situ hybridization (ISH) for HER2.

Each mailing will consist of two duplicate sets of five-core tissue microarray slides that offer a combined total of tenunique paraffin-embedded breast tissue specimens. Laboratories performing FISH for interphase chromosomaltargets in paraffin sections should refer to CY Surveys.


Procedure ISH2 Challenges per ShipmentHER2 gene amplification for breast cancer ! 10

In Situ Hybridization, HER2 ISH2

210 Cytogenetics and Molecular Pathology



Procedure MO MO2 MO3 Challenges per ShipmentMolecular analysis (cells, frozen tissue, or DNA) ! 2Molecular analysis, double volume(cells, frozen tissue, or DNA) ! 2Molecular analysis (paraffin sections) ! 2

Product InformationSurvey MO is designed for laboratories performing molecular analysis of leukemias and lymphomas. Survey MO2contains additional sample vials to accommodate laboratories performing RNA testing in addition to DNA testing.Survey MO3 is for laboratories performing molecular analysis of leukemias and lymphomas on paraffin sections.Note: Laboratories performing immunophenotyping on patients with leukemia and/or lymphoma should referto Survey FL3 on page 159 and Survey MK on page 197.

Each shipment of Survey MO will include two sample vials containing a snap frozen cell pellet, frozen tissue speci-men, or DNA. From each pellet or frozen tissue specimen, at least 100 µg of DNA can be extracted for Southern blotanalysis and/or amplification of antigen receptor (B- and T-cell) gene arrangement or selected (B- and T-cell)translocations (eg, bcr). Survey MO2 will contain four sample vials (two per specimen). Each shipment of SurveyMO3 will contain four 10-micron paraffin sections per specimen.

Product Fulfillment Group MO

Product InformationSurvey MRD is designed for laboratories that perform minimal residual disease testing in cancer patients. The Surveyis specifically designed for laboratories monitoring chronic myelogenous leukemia by measuring the quantity ofBCR/ABL1 transcripts at diagnosis and during or after therapy.

Each shipment of Survey MRD will arrive packed in dry ice and include three sample vials, each holding RNA inethanol.

Analyte MRD Challenges per ShipmentMinimal residual disease ! 3

Molecular Oncology MO, MO2, MO3

Minimal Residual Disease MRD



www.cap.org

Product InformationSurvey SARC is designed for laboratories performing molecular analysis of sarcoma translocations by RT-PCR. Theparticipants may perform testing on the sample for any sarcoma translocation, including EWS/EGR, t(21;22);EWS/FL11, t(11;22); EWS/WT1, t(11;22); FUS/CHOP, t(12;16); PAX3/FKHR, t(2,13); PAX7/FKHR, t(1;13);PDGFB/COL1A1, t(17;22); SYT/SSX1, t(X;18); SYT/SSX2, t(X;18); and SYT/SSX, NOS.

Each shipment of Survey SARC will include one snap frozen cell pellet or extracted RNA from which the participantwill be able to extract approximately 5 to 10 micrograms of RNA.

Analyte SARC Challenges per ShipmentSarcoma translocation ! 1

Product InformationSurvey MSI is designed for laboratories performing microsatellite analysis of paraffin-embedded colorectal carcinoma(or other HNPCC-related tumors) by DNA amplification.

Each shipment will include one H&E slide and two or more 10-micron unstained sections on glass slides to be usedto isolate DNA from tumor and normal tissue for microsatellite instability analysis.

Analyte MSI Challenges per ShipmentMicrosatellite instability (paraffin sections) ! 1

Sarcoma Translocation SARC

Microsatellite Instability MSI

21FORENSIC SCIENCES

Fore

nsic

Scie

nces

Basic Competencies in Forensic Pathology: A ForensicPathology PrimerJoseph A. Prahlow, MD, FCAP, editor

Basic Competencies in Forensic Pathology outlines the concepts andtechniques used in forensic pathology. Prepared by the Forensic PathologyCommittee of the College of American Pathologists in conjunction with theNational Association of Medical Examiners, the primer is intended to be aquick reference for pathologists in training and those who do occasionalforensic autopsies.

Basic Competencies in Forensic Pathology is based on the recommendedguidelines endorsed by the National Association of Medical Examiners forforensic pathology training in anatomic pathology residency programs. Themanual provides aminimum working knowledge of forensic pathology; addresses the differencesbetween a hospital autopsy and a forensic (medicolegal) autopsy; explains the“whats and whys” of forensic autopsies and aids pathologists in recognizingimportant forensic issues; and helps pathologists determine when a particularcase might require more forensic expertise than they are able to provide.

Softcover; 225 pages; 2006

CAP Members: $35

Non-Member Price: $45

Item Number: PUB120

Visit www.cap.org, click on Reference Resources and Publications todownload a sample chapter.

Procedure DNA DNAF Challenges per ShipmentDatabase analysis (whole blood) ! 3Database analysis (filter paper) ! 3Mitochondrial DNA database analysis ! ! 3

Forensic Sciences 213


www.cap.org

Product InformationThis program is designed for DNA analysts performing forensic and mitochondrial DNA testing for the purpose ofcreating and maintaining databases of convicted offenders and missing persons. As an important quality assurancetool, the program allows analysts to comply with proficiency testing requirements of the Quality Assurance Standardsfor Convicted Offender DNA Databasing Laboratories and Quality Assurance Standards for Forensic DNA TestingLaboratories, as well as to compare their results with those of other DNA-testing laboratories. The DNA DatabaseProgram is approved by the American Society of Crime Laboratory Directors/Laboratory Accreditation BoardProficiency Review Committee (ASCLD/LAB PRC).

Participants may report results for short tandem repeats (au-STR and Y-STR), mitochondrial DNA results (mtDNA),and other loci.

Each shipment of Survey DNA will include three tubes, each containing approximately 500 microliters ofanti-coagulated whole blood. Each shipment of Survey DNAF will include three blood-stained filter paper challenges.

Forensic SciencesAnalytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS).

Investigate Other ASCLD/LAB/PRC-approvedPrograms…

! AACC/CAP Alcohol/Volatiles (AL1)! Whole Blood Forensic Toxicology (FTC)! Forensic Identity—Nuclear and Mitochondrial DNA Analysis (FID, FIDM)

DNA Database DNA, DNAF

Analyte FTC Challenges per ShipmentDrugs* ! 4

214 Forensic Sciences



Product InformationThis program is designed for crime laboratories and hospital laboratories that have forensic toxicology divisions thatperform qualitative and quantitative analysis of drugs in whole blood specimens. The Whole Blood ForensicToxicology Program is approved by the American Society of Crime Laboratory Directors/LaboratoryAccreditation Board/Proficiency Review Committee (ASCLD/LAB/PRC).

Each shipment will include three 20.0-mL lyophilized human whole blood specimens and one 50.0-mL lyophilizedurine specimen. Challenges will include a mix of analytes from the list of drugs below.

* See below for a listing of possible analytes.

* and/or metabolite(s)

Whole Blood Forensic Toxicology FTC Drug Listing6-Monoacetylmorphine (6-MAM)7-AminoflunitrazepamAcetaminophenAlprazolamAmitriptylineAmphetamineBenzoylecgonineButalbitalCarisoprodolCocaethyleneCocaineCodeineCyclobenzaprineDelta-9-THCDelta-9-THC-COOHDesipramineDiazepam

DiphenhydramineDiphenylhydantoin

(phenytoin)DoxepinEcgonine methyl esterEphedrineFentanylFluoxetineFlurazepam*Gamma-hydroxybutyrate

(GHB)HydrocodoneHydromorphoneImipramineKetamineLorazepam

Lysergic acid diethylamide(LSD)

Meperidine*MeprobamateMethadoneMethadone metabolite

(EDDP)MethamphetamineMethylenedioxyampheta-

mine (MDA)Methylenedioxymetham-

phetamine (MDMA)Morphine*NordiazepamNordoxepineNorfluoxetine

NorpropoxypheneNortriptylineOxazepamOxycodoneOxymorphoneParoxetinePhencyclidinePhenobarbitalPhenterminePropoxyphenePseudoephedrineSecobarbitalSertralineTemazepamTramadolTrazodoneZolpidem

Whole Blood Forensic Toxicology FTC

Program FR Challenges per ShipmentForensic pathology cases ! 6

Forensic Sciences 215


www.cap.org

Product InformationThis program is designed for hospital-based pathologists, forensic pathologists, residents, fellows, and medical exam-iners/coroners, the Forensic Pathology Program provides the opportunity to develop and refine forensic decision-making skills. The focus of the program is on practical forensic pathology. Each shipment of Survey FR will include aCD-ROM with six case studies illustrating gross and/or microscopic slides and questions related to medicolegaldecision-making materials. Cases may include or reflect anthropologic materials, ballistics, dental identification, DNAidentification, environmental pathology, forensic evidence, injury pattern interpretation, medicolegal issues, toxicolo-gy, natural death, and trace evidence.

Participants in the program will also receive on the CD-ROM detailed discussions of challenging forensic cases whichare downloadable for educational purposes. A list of references is included in the discussion material.

Pathologists can earn a maximum of 12 CME credits (AMA PRA Category 1 Credits™) for completion of an entireyear (see Chapter 3, Continuing Education). For those institutions with multiple pathologists interested in participat-ing and obtaining their own CME credit, the FR1 option is available. Survey FR1 will include only a result form andCME form for an additional pathologist within the same institution.

Product Fulfillment Group FR

Check Out CAP’s Autopsy Pathology ProgramsThe Autopsy Pathology Programs (AU, AUCD) focus on challenging autopsy cases withquestions directed at aspects of interpretive analysis, differential diagnosis, pathophysiology,cause of death, and quality assurance. See page 206 for more information.

Note: The FR1 Program may be ordered only in conjunction with FR.

CME

www.cap.org

ReadLearn

Earn

Forensic Pathology Option: FR1 (For each additional pathologist within the same institution)

Forensic Pathology FR (FR1)

216 Forensic Sciences



Procedure FID FIDM Challenges per ShipmentCalculation challenge ! 1Forensic nuclear DNA analysis ! 3Forensic mitochondrial DNA analysis ! 2

Product InformationThis program is designed for analysts performing forensic casework studies with DNA technology, the ForensicIdentity Program offers an opportunity for comparison to other DNA-testing forensic laboratories. As an importantquality assurance tool, the program allows analysts to comply with proficiency testing requirements of the QualityAssurance Standards for Convicted Offender DNA Databasing Laboratories and Quality Assurance Standards forForensic DNA Testing Laboratories. Participants may report results for short tandem repeats (STR) and other loci.The FID Program is approved by the American Society of Crime Laboratory Directors/Laboratory AccreditationBoard Proficiency Review Committee (ASCLD/LAB PRC).

Each shipment of Survey FID will include simulated forensic casework that includes reference standards for allsuspects and victims, along with other evidentiary material such as vaginal swabs, semen stains, and crime sceneblood stains. Note: The calculation exercise is a paper challenge.

Each shipment of Survey FIDM will contain one reference challenge (blood stain) and one challenge formitochondrial DNA analysis. Specimens for mtDNA analysis may be hair or nails.

Product Fulfillment Group FID

Forensic Identity–Nuclear and MitochondrialDNA Analysis FID, FIDM

22ANALYTE INDEX

Anal

yte

Inde

x

MICROBIOLOGYBacteriology

! Aerobic/Anaerobic Culture andIdentification

! Antibiotic Susceptibility Testing! Direct Bacterial Antigen Detection! Gram Stain

Mycobacteriology! Acid Fast Stain! Mycobacteriology Identification! Mycobacteriology Susceptibility

TestingMycology

! Culture and IdentificationParasitology

! Presence or Absence of Parasites! Identification of Parasites

Virology! Viral Isolation and Identification! Direct Viral Antigen Detection

DIAGNOSTIC IMMUNOLOGYSyphilis SerologyGeneral Immunology

! Alpha-1 Antitrypsin! Alpha-1-Fetoprotein (tumor marker)! Antinuclear Antibody! Anti-Streptolysin O! Anti-Human Immunodeficiency Virus

(Anti HIV)! Complement C3! Complement C4! Hepatitis B Surface Antigen (HBsAg)! Hepatitis B Core Antibody (Anti HBc)! Hepatitis Be Antigen (HBeAg)! Immunoglobulins, total:

IgAIgGIgMIgE

! Infections Mononucleosis! Rheumatoid Factor! Rubella

CHEMISTRYRoutine Chemistry

! Alanine Aminotransferase(ALT or SGPT)

! Albumin! Alkaline Phosphatase! Amylase! Aspartate Aminotransferase

(AST or SGOT)! Biliribin, total! Blood Gases

pHPCO2

PO2

! Calcium, total! Chloride! Cholesterol, total! Cholesterol (HDL)! Creatine Kinase, total! Creatine Kinase, Isoenzyme (CK-MB)! Creatinine! Glucose! Iron, total! Lactate Dehydrogenase (LDH), total! LDH Isoenzymes (LD1/LD2)! Magnesium! Potassium! Sodium! Total Protein! Triglyceride! Urea Nitrogen! Uric Acid

Endocrinology! Cortisol! Free Thyroxine! Human Chorionic Gonadotropin! T3 Uptake! Triiodothyronine! Thyroid Stimulating Hormone! Thyroxine, total

Toxicology! Blood Alcohol! Blood Lead! Carbamazepine! Digoxin! Ethosuximide! Gentamicin! Lithium

Toxicology continued! Phenobarbital! Phenytoin! Primidone! Procainamide and Metabolite! Quinidine! Theophylline! Tobramycin! Valproic acid

HEMATOLOGY! Cell Identification! Erythrocyte Count! Fibrinogen! Hematocrit! Hemoglobin! Leukocyte Count! Platelet Count! Partial Thromboplastin Time! Prothrombin Time! WBC Differential

IMMUNOHEMATOLOGY! ABO Group! D (Rho) Type! Unexpected Antibody Detection! Compatibility Testing! Antibody Identification

GYNECOLOGIC CYTOLOGY! PAP

Approved Proficiency Testing Programs for CLIA

3-Methoxytyramines N Urine Chemistry, Special 595-Hydroxyindoleacetic acid N Urine Chemistry, Special 596-Monoacetylmorphine FTC Whole Blood Forensic Tox 84

T Toxicology 77UDC Forensic Urine Drug

Testing, Confirmatory 80UT Urine Toxicology 75

7-Aminoflunitrazepam FTC Whole BloodForensic Tox 84

11-Deoxycortisol Y, YY Ligand Assay, Special 6917-Hydroxycorticosteroids N Urine Chemistry, Special 5917-Hydroxyprogesterone Y, YY Ligand Assay, Special 6917-Ketosteroids N Urine Chemistry, Special 5925-OH Vitamin D BGS Bone and Growth 7050:50 Mixing Study, APTT CGE, CGEX Coagulation, Extended 124

CGS1 Coag Special, Series 1 12550:50 Mixing Study, PT CGE, CGEX Coagulation, Extended 124Abnormal hemoglobinidentification HBF Fetal Red Cell 113

HG Hemoglobinopathy 112ABO grouping ABO HLA Serologic Typing 177

J, J1 Transfusion Medicine 163JAT Transfusion Medicine,

Automated 165TMCA Transfusion Medicine,

Competency Assessment 166Acetaminophen CZ, CZ2,

CZ2X, CZX,Z Chemistry and TDM 47FTC Whole Blood Forensic

Tox 84LN3 TDM Cal Ver/Lin 92SDS Serum Drug Screen 81T Toxicology 77UDS6, UDS6 Urine Drug Screen 79UT Urine Toxicology 75

Acetone AL1 Whole Blood Alcohol/Volatiles 82

AL2 Serum Alcohol/Volatiles 82SDS Serum Drug Screen 81T Toxicology 77UT Urine Toxicology 75

Acid-fast smear E Mycobacteriology 137E1 Mycobacteriology, Ltd 137

Acid phosphatase C3, C3X, CZ, Chemistry and TDM 47CZ2, CZ2X,CZX

Activated clotting time CT, CT1,CT2, CT3 ACT 128

Activated partial thrombo-plastin time CGL Coagulation, Ltd 123

CGS1 Coag Special, Series 1 125CGS3 Coag Special, Series 3 125CGS4 Coag Special, Series 4 125

Activated protein C resistance CGE, CGEX Coagulation, Extended 124CGS2 Coag Special, Series 2 125

Acylcarnitine BGL Biochemical Genetics 187Adenovirus ID2 Nucleic Acid Amp, Resp 150

VR1 Virology Culture 143VR2 Virology by DFA 143VR4 Virology Ag 144

Adenovirus 40/41 SP Stool Pathogens 136Adjustable micropipette Cal V/L I Instrumentation 104Adrenocorticotropic hormone TM, TMX Tumor Markers 68(ACTH)Alanine aminotransferase C1, C3, C3X Chemistry and TDM 47(ALT/SGPT) CZ, CZ2,

CZ2X, CZXIFS Interfering Substances 106LCW Ltd Chem, Waived 52LN2 Chemistry/Lipid/

Enzyme, Cal Ver/Lin 91LN2ER Chemistry/Lipid/Enzyme,

Cal Ver/Lin Ext Range 91RRS Reference Range Service 102VMC Viral Marker Chemistry 169

Albumin C1, C3, C3X, Chemistry and TDM 47CZ, CZ2,CZ2X, CZXCFS Commutable Frozen

Serum 86FLD Body Fluid 62IFS Interfering Substances 106LN1 Chemistry Cal Ver/Lin

Cal Ver/Lin 91LN1ER Chemistry Cal Ver/Lin

Ext Range 91

Analyte Index 217


www.cap.org

Analyte/Procedure, Program Code, Description, and PageAnalytes/procedures in bboolldd type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS).

Analyte/Procedure Program Description Page Analyte/Procedure Program Description PageCode Code

Albumin (cont.) LN2 Chemistry/Lipid/Enzyme Cal Ver/Lin 91

LN2ER Chemistry/Lipid/EnzymeCal Ver/Lin Ext Range 91

M CSF Chemistry 62RRS Reference Range Service 102

Albumin:creatinine ratio UMC Urine Albumin/Creatinine 116

Alcohol, serum AL2 Serum Alcohol/Volatiles 82LN11 Serum Ethanol Cal

Ver/Lin 95Alcohol, whole blood AL1 Whole Blood Alcohol/

Volatiles 82LN14 Whole Blood Ethanol

Cal Ver/Lin 96Aldolase ADL Aldolase 55Aldosterone, serum RAP Renin and Aldosterone 71Aldosterone, urine N Urine Chemistry, Special 59Alkaline phosphatase (ALP) C1, C3, C3X, Chemistry and TDM 47

CZ, CZ2, CZ2X, CZXIFS Interfering Substances 106LN2 Chemistry/Lipid/Enzyme

Cal Ver/Lin 91LN2ER Chemistry/Lipid/Enzyme

Cal Ver/Lin Ext Range 91RRS3 Reference Range Service 103

Allergens (specific) SE Diagnostic Allergy 158Alpha-1-antitrypsin IG, IGX Immunology, General 151

LN7 Immunology Cal Ver/Lin 93Alpha-fetoprotein (AFP), FP, FPX Maternal Screen 72amniotic fluidAlpha-fetoprotein (AFP), serum FP, FPX Maternal Screen 72

K, KK Ligand Assay, General 67Alpha-hydroxyalprazolam T Toxicology 77

UDC Forensic Urine Drug Testing, Confirmatory 80

Alprazolam FTC Whole Blood Forensic Tox 84T Toxicology 77UT Urine Toxicology 75

Aluminum R Trace Metals 63Amikacin CZ, CZ2, Chemistry and TDM 47

CZ2X, CZX, ZLN3 TDM Cal Ver/Lin 92

Amines UT Urine Toxicology 75Amino acids BGL Biochemical Genetics 187Amitriptyline FTC Whole Blood Forensic Tox 84

Amitriptyline (cont.) T Toxicology 77UT Urine Toxicology 75ZT, ZZT TDM, Special 50

Ammonia C3, C3X, CZ, Chemistry and TDM 47CZ2, CZ2X, CZXLN32 Ammonia Cal Ver/Lin 101

Amniotic Fluid Leakage AFL Amniotic Fluid Leakage 113 (Nitrazine)Amobarbital T Toxicology 77

UT Urine Toxicology 75Amoxapine T Toxicology 77

UT Urine Toxicology 75Amphetamine FTC Whole Blood Forensic Tox 84



Amphetamine group T Toxicology 77UDS, UDS6 Urine Drug Screen 79UT Urine Toxicology 75

Amylase C1, C3, C3X, Chemistry and TDM 47CZ, CZ2, CZ2X, CZXFLD Body Fluid 62IFS Interfering Substances 106LN2 Chemistry/Lipid/Enzyme


Cal Ver/Lin Ext Range 91LN6 Urine Chemistry Cal

Ver/Lin 93RRS Reference Range Service 102U Urine Chemistry, General 58

Analytical balance I Instrumentation 104Anaplasma phagocytophilum TTD Tick-Transmitted Disease 145Androstenedione Y, YY Ligand Assay, Special 69Angiotensin Converting Enzyme ACE Angiotensin Converting

Enzyme 63Anti-A Titer ABT, ABT1 Antibody Titer 171Antibody detection J Transfusion Medicine 163

JAT Transfusion Medicine, Automated 165

PS Platelet Serology 168TMCA Transfusion Medicine,

Competency Assessment 166Antibody detection/ MX1B, HLA Analysis, Class I 180identification (HLA) MX1C

MX1E

218 Analyte Index




Antibody detection/ MX2B, HLA Analysis, Class II 181identification (HLA) (cont.) MX2C,

MX2EAntibody identification J Transfusion Medicine 163

TMCA Transfusion Medicine, Competency Assessment 166

Antibody screen (HLA) MX1B, HLA Analysis, Class I 180MX1C, MX1EMX2B, HLA Analysis, Class II 181 MX2C, MX2E

Anticardiolipin antibody ACL Antiphospholipid Antibody 157Anti-CCP CCP Cyclic Citrullinated

Peptide Ab 156Anti-CMV VM3 Viral Markers - Series 3 173Anti-D Titer ABT, ABT2 Antibody Titer 171Anti-DNA (ds) antibody S2, S4 Immunology, Special 153Anti-DNA topoisomerase (Scl-70) RDS Rheumatic Disease

Special 156Antiendomysial antibody (IgA, IgG) CES Celiac Serology 157Antifungal susceptibility testing F Mycology 138

F1 Yeast 138Antigen detection BAS Bacterial Antigen Detection 134

BCS Blood Culture 131D Bacteriology 130D4 Bacteriology, Ltd 132D6 Rapid Group A Strep 132D8 Group B Strep 133D9 Rapid Group A Strep,

Waived 134HC1 C. trachomatis by DFA 146HC2 HSV by DFA 146HC3 C. trachomatis by EIA 146HC5 C. trachomatis/GC by

DNA Probe 146VR2 Virology by DFA 143VR4 Virology Ag 144

Antigliadin antibody (IgA, IgG) CES Celiac Serology 157Antigliadin deaminated peptide antibody (IgA, IgG) CES Celiac Serology 157Anti-glomerular basement membrane S2 Immunology, Special 153Anti-HAV, IgM VM5 Viral Markers - Series 5 174Anti-HAV, total VM1 Viral Markers - Series 1 172Anti-HBc, IgM VM5 Viral Markers - Series 5 174Anti-HBc, total VM1 Viral Markers - Series 1 172Anti-HBe VM2 Viral Markers - Series 2 173Anti-HBs VM1 Viral Markers - Series 1 172

Anti-HCV VM1 Viral Markers - Series 1 172Anti-histidyl t-RNA synthetase RDS Rheumatic Disease (Jo-1) Special 156Anti-HIV-1 RHIV Anti-HIV-1 174

RHIVW Anti-HIV-1, Waived 174VM1 Viral Markers - Series 1 172

Anti-HIV-2 VM1 Viral Markers - Series 1 172Anti-HIV-1/2 VM1 Viral Markers - Series 1 172

AHIV Anti-HIV-1/2 174AHIVW Anti-HIV-1/2, Waived 174

Anti-HTLV-I/II VM3 Viral Markers - Series 3 173Anti-Jo-1(anti-histidyl t-RNA RDS Rheumatic Disease synthetase) Special 156Anti-LKM LKM Liver-Kidney

Microsomal Ab 155Antimicrobial susceptibility D Bacteriology 130testing

D2 Throat, Urine, GC Cultures 131

D4 Bacteriology, Ltd 132D7 Throat, Urine,

GC Cultures 131Antimitochondrial antibody S2 Immunology, Special 153Antimitochondrial M2 antibody H Antimitochondrial

M2 Ab 154Anti-MPO S2 Immunology, Special 153Antimycobacterial E Mycobacteriology 137susceptibility testingAntineutrophil cytoplasmic S2 Immunology, Special 153 antibody (ANCA) Antinuclear antibody (ANA) ANA, IL Immunology 151APC APC Anti-Parietal Cell Ab 154Antiphospholipid antibody ACL Antiphospholipid Ab 157Anti-PR3 S2 Immunology, Special 153Anti-RNP antibody S2 Immunology, Special 153Anti-Saccharomyces cerevisiae ASC Anti-Saccharomycesantibody cerevisiae Ab 155Anti-Scl-70 (anti-DNA RDS Rheumatic Disease topoisomerase) Special 156Anti-Sm antibody S2 Immunology, Special 153Anti-Sm/RNP antibody S2 Immunology, Special 153Anti-smooth muscle antibody S2 Immunology, Special 153Antisperm antibody IgG ASA Semen Analysis 121Anti-SSA antibody S2 Immunology, Special 153Anti-SSB antibody S2 Immunology, Special 153Anti-SSA/SSB antibody S2 Immunology, Special 153Anti-streptolysin O (ASO) ASO, IL Immunology 151Antithrombin (Activity, Ag) CGE, CGEX Coagulation, Extended 124

CGS2 Coag Special, Series 2 125

Analyte Index 219


www.cap.org


Antithyroglobulin antibody S2, S4 Immunology, Special 153Antithyroid peroxidase (thyroid microsomal Ab) S2, S4 Immunology, Special 153Antitissue transglutaminase antibody (IgA, IgG) CES Celiac Serology 157Anti-Trypanosoma cruzi VM4 Viral Markers - Series 4 173Apolipoprotein A1 ABL Accuracy Based Lipid 52

C3, C3X, CZ, Chemistry and TDM 47 CZ2, CZ2X,CZX

Apolipoprotein B ABL Accuracy Based Lipid 52C3, C3X, CZ, Chemistry and TDM 47 CZ2, CZ2X, CZX

Aspartate aminotransferase C1, C3, C3X, Chemistry and TDM 47(AST/SGOT) CZ, CZ2,

CZ2X, CZXIFS Interfering Substances 106LCW Ltd Chem, Waived 52LN2 Chemistry/Lipid/

Enzyme Cal Ver/Lin 91LN2ER Chemistry/Lipid/

Enzyme Cal Ver/Lin Ext Range 91

RRS Reference Range Service 102

Atenolol T Toxicology 77Atropine T Toxicology 77Automated differential FH1-FH4, Hematology, Auto Diff 108

FH6, FH8-FH10, FH1K-FH4K, FH6K,FH8K-FH10K,FH1P-FH4P, FH6P, FH8P-FH10P

Autopsy pathology AU, AU1 Autopsy Pathology 206AUCD, Autopsy Pathology,AUCD1 CD-ROM 206

B-type natriuretic peptides BNP B-type natriuretic peptides 55LN30 B-type natriuretic peptides

Cal Ver/Lin 101PCARM Plasma Cardiac Markers 53RRS2 Reference Range Service 102

Babesia microti antibody TTD Tick-Transmitted Disease 145 detectionBacteria UAA, UAA1 Automated Urinalysis 116Bacterial detection in platelets BDP Bacterial detection,

platelets 171

Bacterial antigen detection BAS Bacterial Antigen Detection 134

D Bacteriology 130D4 Bacteriology, Ltd 132D6 Rapid Group A Strep 132HC1 C. trachomatisby DFA 146HC3 C. trachomatisby EIA 146HC5 C. trachomatis/GC by

DNA Probe 146Bacterial identification D Bacteriology 130

D1, D2, D3, Throat, Urine, GC D7 Cultures 131D4 Bacteriology, Ltd 132

Bacterial isolate/DNA IDO Nucelic Acid Amp,fingerprinting Organisms 149Barbital T Toxicology 77

UT Urine Toxicology 75Barbiturate group SDS Serum Drug Screen 81

T Toxicology 77UDS, UDS6 Urine Drug Screen 79UT Urine Toxicology 75

Bence Jones proteins UBJP Urine Bence Jones Proteins 56Benzodiazepine group SDS Serum Drug Screen 81

T Toxicology 77UDS, UDS6 Urine Drug Screen 79UT Urine Toxicology 75UTCO Urine Toxicology Carry Over 105

Benzoylecgonine FTC Whole Blood Forensic Tox 84T Toxicology 77UDC Forensic Urine Drug Testing,

Confirmatory 80UDS, UDS6 Urine Drug Screen 79UT Urine Toxicology 75UTCO Urine Toxicology Carry Over 105

Beta-2-glycoprotein I ACL Antiphospholipid Antibody 157Beta-2-microglobulin, serum TM, TMX Tumor Markers 68Beta-2-microglobulin, urine CD Cadmium 83Beta-hydroxybutyrate KET Ketones 57Bilirubin, confirmatory urine DSC Dipstick Confirmatory 116Bilirubin, direct C3, C3X, CZ, Chemistry and TDM 47

CZ2, CZ2X, CZX

LN1 Chemistry Cal Ver/Lin 91LN1ER Chemistry Cal Ver/Lin

Ext Range 91

220 Analyte Index




Bilirubin, direct (cont.) LN2 Chemistry/Lipid/Enzyme Cal Ver/Lin 91

LN2ER Chemistry/Lipid/Enzyme Cal Ver/Lin Ext Range 91

NB, NB2 Neonatal Bilirubin 63Bilirubin, total C1, C3, C3X, Chemistry and TDM 47

CZ, CZ2, CZ2X, CZXCFS Commutable Frozen

Serum 86CM, CMP Clinical Microscopy 115DSC Dipstick Confirmatory 116IFS Interfering Substances 106LM1 Lung Maturity 61LN1 Chemistry Cal Ver/Lin 91LN1ER Chemistry Cal Ver/Lin

Ext Range 91LN2 Chemistry/Lipid/Enzyme


Cal Ver/Lin Ext Range 91NB, NB2 Neonatal Bilirubin 63RRS Reference Range Service 102

Bioavailable testosterone DY Ligand Assay, Special 69Biochemical genetics BGL Biochemical Genetics 187BK viral ID1T Nucleic Acid Amp,

JC and BK 149BK viral load VLS Viral Load 148Blood cell identification BCK, BCP Blood Cell Identification 110

FH1K-FH4K, Hematology, Auto Diff 108FH6K, FH8K-FH10K, FH1P-FH4P, FH6P, FH8P-FH10P

HEK, HEP Basic Hematology 107Blood Culture BCS Blood Culture 131Blood parasite BP Blood Parasite 114

P Parasitology 140Body fluid (cell count) HFC Hemocytometer Fluid

Count 119Body fluid (chemistry) FLD Body Fluid 62Body fluid (crystals) BFC Crystals 117Body fluid (photomicrographs) CM Clinical Microscopy 115Body fluid color photographs CMP Clinical Microscopy 115Bordetella parapertussis BAS Bacterial Antigen Detection 134

IDO Nucleic Acid Amp, Organisms 149

Bordetella pertussis BAS Bacterial Antigen Detection 134

IDO Nucleic Acid Amp, Organisms 149

Borrelia burgdorferi TTD Tick-Transmitted Disease 145

BRCA1/2 MGL3 Molecular Genetics 188Brightfield in situ hybridization ISH In situ hybridization 190Brompheniramine FTC Whole Blood Forensic Tox 84

T Toxicology 77UT Urine Toxicology 75

Buprenorphine T Toxicology 77UT Urine Toxicology 75UDC Forensic Urine Drug

Testing, Confirmatory 80UDS, UDS6 Urine Drug Screen 79

Bupropion T Toxicology 77Butalbital FTC Whole Blood Forensic Tox 84



C. difficile toxin/antigen D Bacteriology 130C. pneumoniae IDO Nucleic Acid Amp,

Organisms 149C. trachomatis(EIA) antigendetection HC3 C. trachomatis by EIA 146C. trachomatis (IF) antigen detection HC1 C. trachomatis by DFA 146C. trachomatis culture VR1 Virology Culture 143C. trachomatis/DNA probe HC5 C. trachomatis/GC by

DNA Probe 146C. trachomatis/NAA HC6, HC6X C. trachomatis/GC by

Nucleic Acid Amp 146CA 15-3 TM, TMX Tumor Markers 68CA 19-9 TM, TMX Tumor Markers 68CA 27.29 TM, TMX Tumor Markers 68CA 72-4 TM, TMX Tumor Markers 68CA 125 LN34 CA-125 Cal Ver/Lin 102

TM, TMX Tumor Markers 68Cadmium, urine CD Cadmium 83Cadmium, whole blood CD Cadmium 83Caffeine C3, CZ2, Chemistry and TDM 47

CZ2X, CZX, ZCalcitonin TM, TMX Tumor Markers 68Calcium C1, C3, C3X, Chemistry and TDM 47

CZ, CZ2, CZ2X, CZX

Analyte Index 221


www.cap.org


Calcium (cont.) IFS Interfering Substances 106LN1 Chemistry Cal Ver/Lin 91LN1ER Chemistry Cal Ver/Lin



Cal Ver/Lin Ext Range 91LN6 Urine Chemistry Cal Ver/Lin 93RRS Reference Range Service 102U Urine Chemistry, General 58

Calcium, ionized AQ, AQ2 Aqueous Blood Gas 73C3, C3X, CZ, Chemistry and TDM 47 CZ2, CZ2X, CZXLN13C Blood Gas Cal Ver/Lin 96Q Fluorocarbon Blood Gas 73

Canavan MGL4 Molecular Genetics 188Candida sp. VS Vaginitis Screen Ag 135Cannabinoids see Delta-9-THC-COOH


Carbamazepine CZ, CZ2, Chemistry and TDM 47CZ2X, CZX, ZLN3 TDM Cal Ver/Lin 92T Toxicology 77UT Urine Toxicology 75

Carbamazepine epoxide T Toxicology 77UT Urine Toxicology 75

Carbamazepine, free CZ, CZ2, Chemistry and TDM 47CZ2X, CZX, Z

Carboxyhemoglobin SO Blood Oximetry 74Carisoprodol FTC Whole Blood Forensic Tox 84


Casts UAA, UAA1 Automated Urinalysis 116CD3 CBT Cord Blood Testing 164

FL, FL1 Flow Cytometry 159LN22 Flow Cytometry Cal Ver/Lin 99SCP Stem Cell Processing 169

CD4 FL, FL1 Flow Cytometry 159LN22 Flow Cytometry Cal Ver/Lin 99

CD8 FL, FL1 Flow Cytometry 159LN22 Flow Cytometry Cal Ver/Lin 99

CD20 PM3 Immunohistochemistry 199CD34 CBT Cord Blood Testing 164

FL4 Flow Cytometry 160SCP Stem Cell Processing 169

CD45 CBT Cord Blood Testing 164SCP Stem Cell Processing 169

CD117 (c-kit) PM1 Immunohistochemistry 199CEA K, KK Ligand Assay, General 67

LN5 Ligand Assay Cal Ver/Lin 92Ceruloplasmin S2, S4 Immunology, Special 153CFU-GM SCP Stem Cell Processing 169Chlordiazepoxide T Toxicology 77

UT Urine Toxicology 75Chloride AQ, AQ2 Aqueous Blood Gas 73

C1, C3, C3X, Chemistry and TDM 47CZ, CZ2, CZ2X, CZXCFS Commutable Frozen

Serum 86IFS Interfering Substances 106LN1 Chemistry Cal Ver/Lin 91LN1ER Chemistry Cal Ver/Lin



Cal Ver/Lin Ext Range 91LN6 Urine Chemistry Cal Ver/Lin 93LN13C Blood Gas Cal Ver/Lin 96Q Fluorocarbon Blood Gas 73RRS2 Reference Range Service 102SW1, SW2, Sweat Analysis Series 64SW3, SW4U Urine Chemistry, General 58

Chlorpheniramine FTC Whole Blood Forensic Tox 84T Toxicology 77UT Urine Toxicology 75

Chlorpromazine UT Urine Toxicology 75Cholesterol ABL Accuracy Based Lipid 88

C1, C3, C3X, Chemistry and TDM 47CZ, CZ2, CZ2X, CZXFLD Body Fluid 62LCW Ltd Chem, Waived 52LN2 Chemistry/Lipid/Enzyme


Cal Ver/Lin Ext Range 91VMC Viral Marker Chemistry 169

Chromium R Trace Metals 63Chromosomal abnormalities CY Cytogenetics 183Cimetidine T Toxicology 77

UT Urine Toxicology 75

222 Analyte Index




Citalopram T Toxicology 77CK isoenzymes CARMI, CRTI Cardiac Markers 54CK-MB (immunochemical) CARM, CRT, Cardiac Markers 54

CRTI, CARMIIFS Interfering Substances 106LN2 Chemistry/Lipid/Enzyme


Cal Ver/Lin Ext Range 91PCARM Plasma Cardiac Markers 53RRS Reference Range Service 102

CK2 (MB) IFS Interfering Substances 106LN2 Chemistry/Lipid/Enzyme


Cal Ver/Lin Ext Range 91Clomipramine T Toxicology 77

UT Urine Toxicology 75Clonazepam UT Urine Toxicology 75

T Toxicology 77Clozapine UT Urine Toxicology 75CO2 C3, C3X, CZ, Chemistry and TDM 47

CZ2, CZ2X,CZXIFS Interfering Substances 106LN1 Chemistry Cal Ver/Lin 91LN2 Chemistry/Lipid/Enzyme



Cocaethylene FTC Whole Blood Forensic Tox 84T Toxicology 77UT Urine Toxicology 75

Cocaine FTC Whole Blood Forensic Tox 84T Toxicology 77UDS, UDS6 Urine Drug Screen 79UT Urine Toxicology 75

Codeine FTC Whole Blood Forensic Tox 84T Toxicology 77UT Urine Toxicology 75UDC Forensic Urine Drug

Testing, Confirmatory 80Comparative genomic CYCGH CYCGH Microarray 185hybridizationCompatibility testing J Transfusion Medicine 163


Complement C3 IG, IGX Immunology, General 151LN7 Immunology Cal Ver/Lin 93

Complement C4 IG, IGX Immunology, General 151LN7 Immunology Cal Ver/Lin 93

Complex PSA K, KK Ligands Assay, General 67Conductivity SW1, SW2, Sweat Analysis Series 64

SW3, SW4Connexin-26 MGL3 Molecular Genetics 188Copper R Trace Metals 63Coproporphyrins N Urine Chemistry, Special 59Coronavirus ID2 Nucleic Acid Amp, Resp 150Cortisol C1, C3, C3X, Chemistry and TDM 47

CZ, CZ2, CZ2X, CZXCFS Commutable Frozen

Serum 86LN5 Ligand Assay Cal Ver/Lin 92K, KK Ligands Assay, General 67

Cortisol, urinary free N Urine Chemistry, Special 59Cotinine T Toxicology 77

UT Urine Toxicology 75C-peptide ING Insulin, Gastrin, C-Peptide,

PTH 71C-reactive protein (CRP) CRP, IL Immunology 151

LN12 C-Reactive Protein Cal Ver/Lin 95RRS2 Reference Range Service 102

C-reactive protein, high-sensitivity hsCRP High Sensitivity C-reactive(hsCRP) Protein 57

LN21 High Sensitivity C-ReactiveProtein Cal Ver/Lin 98

C-telopeptide (CTX) BU Bone and Mineral, Urine 70Creatine kinase (CK) C1, C3, C3X, Chemistry and TDM 47

CZ, CZ2X, CZ2, CZXCARM, CARM, Cardiac Markers 54CRT, CRTIIFS Interfering Substances 106LN2 Chemistry/Lipid/Enzyme


Cal Ver/Lin Ext Range 91Creatinine AQ2 Aqueous Blood Gas 73

BU Bone and Mineral, Urine 70C1, C3, C3X, Chemistry and TDM 47CZ, CZ2, CZ2X, CZXCD Cadmium 83CFS Commutable Frozen

Serum 86

Analyte Index 223


www.cap.org


Creatinine (cont.) FLD Body Fluid 62IFS Interfering Substances 106LN1 Chemistry Cal Ver/Lin 91LN1ER Chemistry Cal Ver/Lin



Cal Ver/Lin Ext Range 91LN6 Urine Chemistry Cal Ver/Lin 93LN20 Urine Albumin Cal Ver/Lin 98LN24 Creatinine Cal Ver/Lin 99RRS Reference Range Service 102SCO Serum Carry Over 105U Urine Chemistry, General 58UDC Forensic Urine Drug

Testing, Confirmatory 80UMC Urine Albumin/Creatinine 116

Crossmatching J Transfusion Medicine 163MX1B, MX1C HLA Analysis, Class I 180MX2B, MX2C HLA Analysis Class II 181TMCA Transfusion Medicine,

Competency Assessment 166Cryptococcal antigen detection F Mycology 138

F1 Yeast 138Cryptosporidium immunoassay P, P3, P4, P5 Parasitology 140Crystals BFC Body Fluid Crystals 117

UAA Automated Urinalysis 116URC Urine Crystals 117

Cyclic citrullinated peptide CCP Anti-Cyclic citrullinatedantibody peptide ab 156Cyclobenzaprine FTC Whole Blood Forensic Tox 84


Cyclosporine CS Immunosuppressive Drugs 50LN31 Immunosuppressive Drugs

Cal Ver/Lin 101CYP2C9 PGX Pharmacogenetics 187CYP2C19 PGX Pharmacogenetics 187CYP2D6 PGX Pharmacogenetics 187Cystatin C CYS Cystatin C 65Cystic fibrosis MGL2, MGL5 Molecular Genetics 188Cytology PT PAPCPT PAP PT, Conventional 200

PAPJPT PAP PT, All technologies 200PAPKPT PAP PT, SurePath 200PAPMPT PAP PT, ThinPrep 200

Cytomegalovirus (CMV) ID1 Nucleic Acid Amp, Viruses 149VR1 Virology Culture 143

Cytomegalovirus (CMV)(cont.) VR2 Virology by DFA 143VR3 Virology 144

Cytomegalovirus viral load VLS Viral Load 148Cytopathology, gynecologic PAPCE1 PAP Ed, Conventional 201

PAPJE1 PAP Ed, All technologies 201PAPKE1 PAP Ed, SurePath 201PAPME1 PAP Ed, ThinPrep 201

Cytopathology, non-gynecologic NGC, NGC1 Interlab Comparison Prgm 202Cytopreparation differential HFC Hemocytometer Fluid

Count 119D-dimer CGDF Coagulation, D-dimer/FDP 123

CGL Coagulation, Ltd 123WBDD Whole Blood D-dimer 127

Delta-9-THC FTC Whole Blood Forensic Tox 84T Toxicology 77

Delta-9-THC-COOH FTC Whole Blood Forensic Tox 84T Toxicology 77UDC Forensic Urine Drug

Testing, Confirmatory 80UDS, UDS6 Urine Drug Screen 79UT Urine Toxicology 75UTCO Urine Toxicology Carry Over 105

Deoxypyridinoline (DPD) BU Bone and Mineral, Urine 70Dermatopathology DPATH, Online Digital Slide Program 195

DPATH1Dermatophyte identification F Mycology 138Desipramine FTC Whole Blood Forensic Tox 84

T Toxicology 77UT Urine Toxicology 75ZT, ZZT TDM, Special 50

Dextromethorphan T Toxicology 77UT Urine Toxicology 75

DHEA sulfate Y, YY Ligand Assay, Special 69DIA (Dimeric inhibin A) FP Maternal Screen 72Diazepam FTC Whole Blood Forensic Tox 84


Differential, automated FH1-4, FH6, Hematology, Auto Diff 108FH8-FH10

Digital slide program in fine- FNA, FNA1 Online Digital Slide needle aspiration, online Program 203Digoxin CZ, CZ2, Chemistry and TDM 47

CZ2X, CZX, ZLN3 TDM Cal Ver/Lin 92T Toxicology 77

Digoxin, free CZ, CZ2, Chemistry and TDM 47CZ2X, CZX, Z

224 Analyte Index




Dihydrocodone T Toxicology 77Diltiazem T Toxicology 77Dimeric inhibin A (DIA) FP, FPX Maternal Screen 72Diphenhydramine FT Fructosamine 61


Diphenylhydantoin FTC Whole Blood Forensic Tox 84Direct antiglobulin testing DAT Direct antiglobulin testing 165

TMCAD Transfusion Medicine, Competency Assessment 167

Direct bilirubin C1, C3, C3X, Chemistry and TDM 47CZ, CZ2, CZ2X, CZXLN1 Chemistry Cal Ver/Lin 91LN1ER Chemistry Cal Ver/Lin Ext

Range 91LN2 Chemistry/Lipid/Enzyme


Cal Ver/Lin Ext Range 91NB, NB2 Neonatal Bilirubin 63

Disopyramide CZ, CZ2, Chemistry and TDM 47CZ2X, CZX, Z

DMD/Becker MGL2 Molecular Genetics 188DNA analysis DL, DML HLA Molecular Typing 179

DNA, DNAF DNA Database 213FID, FIDM Forensic Identity 216ML HLA Molecular Typing 179MO Molecular Oncology 189PAR, PARF Parentage/Relationship 176

DNA content/cell cycle analysis FL, FL2 Flow Cytometry 159DNA database DNA, DNAF DNA Database 213Dopamine N Urine Chemistry, Special 59Doxepin FTC Whole Blood Forensic Tox 84


Doxylamine UT Urine Toxicology 75Ecgonine methyl ester FTC Whole Blood Forensic Tox 84


Electrophoresis HG Hemoglobinopathy 112LPE Lipoprotein Electrophoresis 56M CSF Chemistry 62SPE Protein Electrophoresis 56UBJP Urine Bence Jones

Proteins 56

Eluate elution ELU Eluate 170Embryology EMB Embryology 122Enterovirus ID1 Nucleic Acid Amp, Viruses 149

VR1 Virology Culture 143Eosinophils, urine SCM2 Special Clinical Microscopy 118Ephedrine FTC Whole Blood Forensic Tox 84


Ephedrine/Pseudoephedrine T Toxicology 77Epidermal Growth Factor PM4 EGFR by Immunohisto-Receptor (EGFR) chemistry 199Epinephrine N Urine Chemistry, Special 59

T Toxicology 77Epithelial cells UAA1 Automated Urinalysis 116Epstein-Barr virus (EBV) VR3 Virology 144

ID1 Nucleic Acid Amp, Viruses 149ISH In situ hybridization 190

Epstein-Barr virus viral load VLS Viral Load 148Erythrocyte sedimentation rate ESR, ESR1 ESR 111Erythropoietin EPO Erythropoietin 71Estradiol LN8 Reproductive Endocrin-

ology Cal Ver/Lin 94Y, YY Ligand Assay, Special 69

Estriol, unconjugated (uE3) FP, FPX Maternal Screen 72Y, YY Ligand Assay, Special 69

Estrogen receptors PM2 ER, PR by Immunohisto-chemistry 199

Ethanol AL1 Alcohol/Volatiles 82AL2 Serum Alcohol/Volatiles 82LN11 Serum Ethanol Cal Ver/Lin 95LN11ER Serum Ethanol Cal Ver/Lin

Ext Range 95LN14 Whole Blood Ethanol Cal

Ver/Lin 96T Toxicology 77UDS, UDS6 Urine Drug Screen 79UT Urine Toxicology 75

Ethosuximide CZ, CZ2, CZ2X, CZX, Z Chemistry and TDM 47

Ethylene glycol T Toxicology 77UT Urine Toxicology 75

Factor V Leiden MGL1 Molecular Genetics 188Factor VIII CGE Coagulation, Extended 124

CGEX Coagulation, Extended 124CGS3 Coag Special, Series 3 125

Factor VIII Inhibitor CGE Coagulation, Extended 124CGEX Coagulation, Extended 124

Analyte Index 225


www.cap.org


Familial dysautonomia MGL4 Molecular Genetics 188Famotidine T Toxicology 77Fecal Fat FCFS Fecal Fat 64Fecal suspension (immunoassay) P, P3, P4, P5 Parasitology 140Fecal suspension (modified P, P3, P4, P5 Parasitology 140acid fast stain)Fecal suspension (wet mount) P, P3, P4 Parasitology 140Fentanyl T Toxicology 77

UT Urine Toxicology 75Fern test CMM, CMMP Clinical Microscopy 117Ferritin C3, C3X, CZ, Chemistry and TDM 47

CZ2, CZ2X, CZXK, KK Ligand Assay, General 67LN5 Ligand Assay Cal Ver/Lin 92RRS Reference Range Service 102

Fetal fibronectin FF Fetal Fibronectin 72Fetal hemoglobin (APT) APT Fetal Hemoglobin 113Fetal hemoglobin detection HBF Fetal Red Cell 113Fetal membrane rupture ROM Rupture of Fetal Membrane 113Fetal red cell quantitation HBF Fetal Red Cell 113

TMCAF Transfusion Medicine, Competency Assessment 168

Fetal screen (Rosette testing) HBF Fetal Red Cell 113TMCAF Transfusion Medicine,

Competency Assessment 168Fibrinogen CGL Coagulation, Ltd 123Fibrinogen antigen CGE, CGEX Coagulation, Extended 124Fibrinogen degradation products, CGDF Coagulation, D-dimer/FDP 123 plasma

CGL Coagulation, Ltd 123Fibrinogen degradation products, CGDF Coagulation, D-dimer/FDP 123serum

CGL Coagulation, Ltd 123FISH for breast carcinoma CYH Fluorescence In situ (HER2 gene amplification) hybridization - Breast

Cancer 185FISH for constitutional and CYF Fluorescence In situhematologic disorders hybridization 184FISH for paraffin-embedded tissue CYH Fluorescence In situ

hybridization - Breast Cancer 185

CYJ Fluorescence In situ hybridization, Glioma 186

CYK Fluorescence In situ hybridization, Sarcoma tissue or Pediatric neoplasm 186

CYL Fluorescence In situ hybridization, Lymphoma 186

FISH for urothelial carcinoma CYI Fluorescence In situ hybridization - Urothelial Carcinoma 184

Flecainide CZ, CZ2, CZ2X, CZX, Z Chemistry and TDM 47

Fluorescent microscope check I Instrumentation 104Fluorescent polarization assay LM, LM1 Lung Maturity 61Fluoxetine FTC Whole Blood Forensic Tox 84


Flurazepam FTC Whole Blood Forensic Tox 84T Toxicology 77UT Urine Toxicology 75

Folate, RBC FOL RBC Folate 68Folate, serum K, KK Ligand Assay, General 67

LN5 Ligand Assay Cal Ver/Lin 92RRS2 Reference Range Service 102

Follicle-stimulating hormone LN8 Reproductive Endocrinology (FSH) Cal Ver/Lin 94

Y, YY Ligand Assay, Special 69Forensic identity (DNA) FID, FIDM Forensic Identity 216Forensic pathology FR, FR1 Forensic Pathology 215Forensic toxicology FTC Whole Blood Forensic Tox 84Fragile X MGL1 Molecular Genetics 188Free testosterone DY Ligand Assay, Special 69Friedreich ataxia MGL2 Molecular Genetics 188Fructosamine FT Fructosamine 61Fungal culture CBT Cord Blood Testing 164

SCP Stem Cell Processing 169Fungus identification F Mycology 138

F1 Yeast 138Gamma globulin M CSF Chemistry 62Gamma glutamyl transferase (GGT) C3, C3X, CZ, Chemistry and TDM 47

CZ2, CZ2X, CZXIFS Interfering Substances 106LN2 Chemistry/Lipid/Enzyme



Gamma hydroxybutyrate FTC Whole Blood Forensic Tox 84UT Urine Toxicology 75

Gardnerella vaginalis VS Vaginitis Screen Ag 135Gastric occult blood GOCB Gastric Occult Blood 119Gastric pH GOCB Gastric Occult Blood 119Gastrin ING Insulin, Gastrin, C-Peptide,

PTH 71

226 Analyte Index




Genomic copy number array CYCGH CYCGH Microarray 185Gentamicin CZ, CZ2,

CZ2X, CZX, Z Chemistry and TDM 47

LN3 TDM Cal Ver/Lin 92Giardia immunoassay P, P3, P4, P5 Parasitology 140Giemsa stain BP Blood Parasite 114

P Parasitology 140Glioma by FISH CYJ Fluorescence In situ

hybridization 186Glucose AQ2 Aqueous Blood Gas 73

C1, C3, C3X, Chemistry and TDM 47CZ, CZ2, CZ2X, CZXCFS Commutable Frozen Serum 86CM, CMP Clinical Microscopy 115FLD Body Fluid 62HCC Waived Combination 112IFS Interfering Substances 106LCW Ltd Chem, Waived 52LN1 Chemistry Cal Ver/Lin 91LN1ER Chemistry Cal Ver/Lin



Cal Ver/Lin Ext Range 91LN6 Urine Chemistry Cal Ver/Lin 93LN13C Blood Gas Cal Ver/Lin 96LN17 Whole Blood Glucose

Cal Ver/Lin 97M CSF Chemistry 62Q Fluorocarbon Blood Gas 73RRS2 Reference Range Service 102U Urine Chemistry, General 58WB2 Whole Blood Glucose,

Waived 65WBG Whole Blood Glucose 65

Glucose-6-phosphate G6PDS Glucose-6-phosphatedehydrogenase dehydrogenase 61Glycohemoglobin GH2 Glycohemoglobin 60

LN15 Glycohemoglobin Cal Ver/Lin 97

Gram stain D Bacteriology 130D2, D3, D7 Throat, Urine, GC Cultures 131D4 Bacteriology, Ltd 132D5 Gram Stain 132

Group A strep antigen detection D Bacteriology 130

Group A strep antigen detection D4 Bacteriology, Ltd 132D6 Rapid Group A Strep 132D9 Rapid Group A Strep,

Waived 134Group B Strep D8 Group B Strep 133Growth hormone Y, YY Ligand Assay, Special 69Gyn cytology PAPCPT PAP PT, Conventional 200

PAPJPT PAP PT, All technologies 200PAPKPT PAP PT, SurePath 200PAPMPT PAP PT, ThinPrep 200

Gyn cytopathology PAPCE1 PAP Ed, Conventional 201PAPJE1 PAP Ed, All technologies 201PAPKE1 PAP Ed, SurePath 201PAPME1 PAP Ed, ThinPrep 201

Haloperidol UT Urine Toxicology 75Haptoglobin IG, IGX Immunology, General 151

S2, S4 Immunology, Special 153HBeAg VM2 Viral Markers - Series 2 173HBsAg VM1 Viral Markers - Series 1 172HBV HBVL Hepatitis Viral Load 147

NAT Nucleic Acid Testing 175HCV NAT Nucleic Acid Testing 175HCV genotyping/qualitative HCVN, HCV2 Hepatitis Viral Load 147HCV viral load HCVN, HCV2 Hepatitis Viral Load 147HDL cholesterol ABL Accuracy Based Lipid 88

C1, C3, C3X, Chemistry and TDM 47CZ, CZ2, CZ3X, CZXLCW Ltd Chem, Waived 52LN2 Chemistry/Lipid/Enzyme


Cal Ver/Lin Ext Range 91Helicobacter pylori antibody S2, S4 Immunology, Special 153

S5 H. pylori IgG Antibody 153VR3 Virology 144

Helicobacter pylori antigen HPS H. pylori Antigen, stool 135Hematocrit AQ, AQ2 Aqueous Blood Gas 73

CBT Cord Blood Testing 164FH1-FH4, Hematology, Auto Diff 108FH6, FH8-FH10, FH1K-FH4K, FH6K, FH8K-FH10K, FH1P-FH4P, FH6P, FH8P-FH10PHE, HEK, Basic Hematology 107HEP

Analyte Index 227


www.cap.org


Hematocrit (cont.) RRS4 Reference Range Service 103SCP Stem Cell Processing 169SO Blood Oximetry 74

Hemochromatosis MGL1 Molecular Genetics 188Hemocytometer fluid count HFC Hemocytometer Fluid

Count 119Hemoglobin CBT Cord Blood Testing 164

CM, CMP Clinical Microscopy 115FH1-FH4, Hematology, Auto Diff 108FH6, FH8-FH10, FH1K-FH4K, FH6K, FH8K-FH10K, FH1P-FH4P, FH6P, FH8P-FH10PHCC Waived Combination 112HE, HEK, Basic Hematology 107HEPLN9 Hematology Cal Ver/Lin 94RRS4 Reference Range Service 103SO Blood Oximetry 74

Hemoglobin, estimated AQ, AQ2 Aqueous Blood Gas 73Hemoglobin, plasma PHG Plasma Hemoglobin 65Hemoglobin A1C GH2 Glycohemoglobin 60

LN15 Glycohemoglobin Cal Ver/Lin 97Hemoglobin A2 HG Hemoglobinopathy 112Hemoglobin F HBF Fetal Red Cell 113

HG Hemoglobinopathy 112Hemoglobin S HG Hemoglobinopathy 112

SCS Sickle Cell Screen 112Hemoglobin S/C MGL2 Molecular Genetics 188Hemolytic Complement, Total CH50 Total Complement 152Hemosiderin, urine SCM1 Special Clinical Microscopy 118Heparin Assay CGS4 Coag Special, Series 4 125Heparin induced thrombcytopenia CGS5 Coag, Special, HIT 125

CGE, CGEX Coagulation, Extended 124Hepatitis B viral load HBVL Hepatitis Viral Load 147Hepatitis C viral load HCVN, HCV2 Hepatitis Viral Load 147HER2 gene amplification by ISH ISH2 In situ hybridization 190HER2 gene amplification by FISH CYH Fluorescence In situ

hybridization - Breast Cancer 185HER2 by immunohistochemistry HER2 HER2 by immunohisto-

chemistry 198Herpes simplex virus antibody VR3 Virology 144 detectionHerpes simplex virus antigen HC2 HSV by DFA 146detection

VR2 Virology by DFA 143

Herpes simplex virus culture HC4 HSV Culture 146VR1 Virology Culture 143

Herpes simplex virus/NAA ID1 Nucleic Acid Amp, Viruses 149

HHV6 ID1 Nucleic Acid Amp, Viruses 149HHV8 ID1 Nucleic Acid Amp, Viruses 149High-sensitivity C-reactive protein hsCRP hsCRP 57

LN21 High Sensitivity C-Reactive Protein Cal Ver/Lin 98

Histotechnology quality HQIP HistoQIP 196 improvementHIV NAT Nucleic Acid Testing 175HIV-1 genotyping HIV HIV Viral Load 147

HV2 HIV Viral Load 147HIV-1 p24 antigen VM3 Viral Markers - Series 3 173HIV-RNA viral load HIV, HV2 HIV Viral Load 147HLA-A,B,C antibody identification MX1B, MX1C,

MX1E HLA Analysis, Class I 180MX2B, MX2C, MX2E HLA Analysis, Class II 181

HLA-(Class I/II) crossmatching MX1B, MX1C,MX1E HLA Analysis, Class I 180MX2B, MX2C,MX2E HLA Analysis, Class II 181

HLA-A,B,C typing (serologic) HLAS, HLAS1 HLA Serologic Typing 177HLA-B27 typing B27 HLA-B27 Typing 179HLA-DR, DQ typing (serologic) HLAS HLA Serologic Typing 177HLA molecular typing DL, DML, ML HLA Molecular Typing 179Homocysteine HMS Homocysteine 57

LN16 Homocysteine Cal Ver/Lin 97Homovanillic acid N Urine Chemistry, Special 59Human chorionic C1, C3, C3X,gonadotropin (hCG), serum CZ, CZ2,

CZ2X, CZX Chemistry and TDM 47FP, FPX Maternal Screen 72HCG, IL Immunology 151K, KK Ligand Assay, General 67

Human chorionic gonadotropin LN5 Ligand Assay Cal Ver/Lin 92 (hCG), serum

LN8 Reproductive Endo-crinology Cal Ver/Lin 94

SCO Serum Carry Over 105Human chorionic gonadotropin CM, CMP Clinical Microscopy 115 (hCG), urineHuman metapneumovirus ID2 Nucleic Acid Amp, Resp 150Human papillomavirus HPV Molecular Microbiology 150

ISH In situ hybridization 190Human papillomavirus-Digene CHPVD Cytology, Nucleic Acid Amp 204Human papillomavirus-ThinPrep CHPVM Cytology, Nucleic Acid Amp 204

228 Analyte Index




Human papillomavirus-SurePath CHPVK Cytology, Nucleic Acid Amp 204Human papillomavirus-Mixed CHPVJ Cytology, Nucleic Acid Amp 204Huntington Disease MGL2 Molecular Genetics 188Hydrocodone FTC Whole Blood Forensic Tox 84



Hydromorphone FTC Whole Blood Forensic Tox 84T Toxicology 77UDC Forensic Urine Drug


Hydroxyzine T Toxicology 77UT Urine Toxicology 75

Ibuprofen T Toxicology 77UT Urine Toxicology 75

IgA IG, IGX Immunology, General 151LN7 Immunology Cal Ver/Lin 93RRS3 Reference Range Service 103SPE Protein Electrophoresis 56

IgD S2, S4 Immunology, Special 153IgE IG, IGX Immunology, General 151

K, KK Ligand Assay, General 67SE Diagnostic Allergy 158

IgE multi-allergen screen SE Diagnostic Allergy 158IGF-1 (somatomedin C) BGS Bone and Growth 70

Y, YY Ligand Assay, Special 69IgG IG, IGX Immunology, General 151

LN7 Immunology Cal Ver/Lin 93M CSF Chemistry 62RRS3 Reference Range Service 103S2, S4 Immunology, Special 153SCO Serum Carry Over 105SPE Protein Electrophoresis 56

IgG subclass proteins S2, S4 Immunology, Special 153IgM IG, IGX Immunology, General 151

LN7 Immunology Cal Ver/Lin 93RRS3 Reference Range Service 103SPE Protein Electrophoresis 56

Imipramine FTC Whole Blood Forensic Tox 84T Toxicology 77UT Urine Toxicology 75ZT, ZZT TDM, Special 50

Immature granulocyte parameter FH9, FH9K, Hematology, Auto Diff 108 FH9P

Immunohistochemistry HER2 HER2 by Immunohisto-chemistry 198

MK Immunohistochemistry 197PM1 CD117 by Immunohisto-

chemistry 199PM2 ER, PR by Immunohisto-

chemistry 199PM3 CD20 by Immunohisto-

chemistry 199PM4 EGFR by Immunohisto-

chemistry 199India ink IND India Ink 139Infectious mononucleosis IL, IM Immunology 151

IMW Infectious Mononucleosis, Waived 151

Influenza viruses ID2 Nucleic Acid Amp, Resp 150VR1 Virology Culture 143VR2 Virology by DFA 143VR4 Virology Ag 144

In situ hybridization ISH In situ hybridization 190ISH2 In situ hybridization HER2 190

Instrument function I Instrumentation 104Instrument linearity I Instrumentation 104

LN1 Chemistry Cal Ver/Lin 91LN1ER Chemistry Cal Ver/Lin



Cal Ver/Lin Ext Range 91LN3 TDM Cal Ver/Lin 92LN5 Ligand Assay Cal Ver/Lin 92LN6 Urine Chemistry Cal Ver/Lin 93LN7 Immunology Cal Ver/Lin 93LN8 Reproductive Endocrinology

Cal Ver/Lin 94LN9 Hematology Cal Ver/Lin 94LN9ER Hematology Cal Ver/Lin

Ext Range 94LN11 Serum Ethanol Cal Ver/Lin 95LN11ER Serum Ethanol Cal Ver/Lin

Ext Range 95LN12 C-Reactive Protein Cal

Ver/Lin 95LN13 Blood Gas Cal Ver/Lin 96LN13C Blood Gas Cal Ver/Lin 96LN14 Whole Blood Ethanol Cal

Ver/Lin 96LN15 Glycohemoglobin Cal Ver/Lin 97

Analyte Index 229


www.cap.org


Instrument linearity (cont.) LN16 Homocysteine Cal Ver/Lin 97LN17 Whole Blood Glucose Cal

Ver/Lin 97LN18 Reticulocyte Cal Ver/Lin 98LN19 Reticulocyte Cal Ver/Lin 98LN20 Urine Albumin Cal Ver/Lin 98LN21 High Sensitivity C-Reactive

Protein Cal Ver/Lin 98LN22 Flow Cytometry Cal Ver/Lin 99LN23 PSA Cal Ver/Lin 99LN24 Creatinine Cal Ver/Lin 99LN25 Troponin I Cal Ver/Lin 100LN27 Troponin T Cal Ver/Lin 100LN30 BNP Cal Ver/Lin 101LN31 Immunosuppressive Drugs

Cal Ver/Lin 101LN32 Ammonia Cal Ver/Lin 101LN33 Serum Myoglobin Cal

Ver/Lin 102LN34 CA-125 Cal Ver/Lin 102

Insulin ING Insulin, Gastrin, C-Peptide, PTH 71

Interleukin-2 receptor TM, TMX Tumor Markers 68(soluble IL-2)International Normalized Ratio CGL Coagulation, Ltd 123 (INR)

CGS1 Coag Special, Series 1 125CGS4 Coag Special, Series 4 125WP3, WP4, Whole Blood Coagulation 126 WP6, WP7,WP9WP8 Coagulation, Waived 126

Ionized calcium AQ, AQ2 Aqueous Blood Gas 73C3, CZ, CZ2, CZX Chemistry and TDM 47LN13C Blood Gas Cal Ver/Lin 96Q Fluorocarbon Blood Gas 73

Iron C1, C3, C3X, Chemistry and TDM 47 CZ, CZ2, CZ2X, CZXIFS Interfering Substances 106LN1 Chemistry Cal Ver/Lin 91LN1ER Chemistry Cal Ver/Lin



Cal Ver/Lin Ext Range 91RRS Reference Range Service 102

Isopropanol AL1 Alcohol/Volatiles 82AL2 Serum Alcohol/Volatiles 82T Toxicology 77UT Urine Toxicology 75

JC virus detection ID1T Nucleic Acid Amp, JC and BK 149

Jo-1 (anti-histidyl t-RNA RDS Rheumatic Disease Special 156synthetase)Kappa/lambda ISH In situ hybridization 190Kappa/lambda ratio IG, IGX Immunology, General 151

S2, S4 Immunology, Special 153Karyotype nomenclature CY Cytogenetics 183Ketamine FTC Whole Blood Forensic Tox 84


Ketones CM, CMP Clinical Microscopy 115KET Ketones 57

KOH prep CMM, CMMP Clinical Microscopy 117Laboratory Preparedness LPX Laboratory Preparedness Exercise Exercise 136Laboratory Management Index LMIP Quality Management Tools 38 ProgramLactate AQ, AQ2 Aqueous Blood Gas 73

C3, C3X, CZ, Chemistry and TDM 47CZ2, CZ2X, CZXFLD Body Fluid 62LN13C Blood Gas Cal Ver/Lin 96M CSF Chemistry 62

Lactate dehydrogenase (LD) C1, C3, C3X, Chemistry and TDM 47 CZ, CZ2, CZ2X, CZXCARM, Cardiac Markers 54CARMI, CRTI,CRTFLD Body Fluid 62IFS Interfering Substances 106LN2 Chemistry/Lipid/Enzyme


Cal Ver/Lin Ext Range 91M CSF Chemistry 62RRS Reference Range Service 102SCO Serum Carry Over 105

LD isoenzymes CARMI, CRTI Cardiac Markers 54LD1/LD2 ratio CARMI, CRTI Cardiac Markers 54LDL cholesterol ABL Accuracy Based Lipid 88

C1, C3, C3X, Chemistry and TDM 47 CZ, CZ2, CZ2X, CZX

230 Analyte Index




LDL cholesterol (cont.) LCW Ltd Chem, Waived 52Lamotrigine T Toxicology 77Lead (blood) BL Blood Lead 83Lecithin:sphingomyelin (L:S) ratio LM, LM1 Lung Maturity 61Legionella pneumophila IDO Nucleic Acid Amp,

Organisms 149Legionella pneumophila BAS Bacterial Antigen Detection 134antigen detection

LAS Legionella Ag, Urine 134Leukemia/lymphoma immuno-phenotype FL3, FL3CD Flow Cytometry 159Leukocyte esterase CM, CMP Clinical Microscopy 115Leukocyte-reduced platelets TRC Transfusion-Related

Cell Count 170Leukocyte-reduced RBC TRC Transfusion-Related

Cell Count 170Leukocyte, stool CMM, CMMP Clinical Microscopy 117Levorphanol UT Urine Toxicology 75Lidocaine CZ, CZ2, Chemistry and TDM 47

CZ2X, CZX, ZLN3 TDM Cal Ver/Lin 92T Toxicology 77UT Urine Toxicology 75

Lipase CZ, CZ2, Chemistry and TDM 47CZ2X, CZXIFS Interfering Substances 106LN2 Chemistry/Lipid/Enzyme



Lipids ABL Accuracy Based Lipid 88C1, C3, C3X, CZ, CZ2, CZ2X, CZX Chemistry and TDM 47LN2 Chemistry/Lipid/Enzyme

Cal Ver/Lin 91Lipoprotein (a) ABL Accuracy Based Lipid 88

C1,C3, C3X, Chemistry and TDM 47 CZ, CZ2, CZ2X, CZX

Lipoprotein-associated PLA Lp-PLA2 53phospholipaseLipoprotein electrophoresis LPE Lipoprotein

Electrophoresis 56Lithium C1, C3, C3X, Chemistry and TDM 47

CZ, CZ2, CZ2X, CZX, ZLN3 TDM Cal Ver/Lin 92T Toxicology 77

Liver-kidney microsomal antibody LKM Liver-Kidney Microsomal Ab 155

Lorazepam FTC Whole Blood Forensic Tox 84T Toxicology 77UDC Forensic Urine Drug


Loxapine T Toxicology 77UT Urine Toxicology 75

Lupus anticoagulant (scrn, conf) CGE, CGEX Coagulation, Extended 124CGS1 Coag Special, Series 1 125

Luteinizing hormone (LH) LN8 Reproductive Endocrino-logy Cal Ver/Lin 94

Y, YY Ligands Assay, Special 69Lyme disease TTD Tick-Transmitted Disease 145Lymphocyte immunophenotyping FL, FL1 Flow Cytometry 159Lymphoma by FISH CYL Fluorescence In situ

hybridization 186Lysergic acid diethylamide (LSD) FTC Whole Blood Forensic Tox 84

UDS, UDS6 Urine Drug Screen 79UT Urine Toxicology 75

Magnesium C1, C3, C3X, Chemistry and TDM 47CZ, CZ2, CZ2X, CZXIFS Interfering Substances 106LN1 Chemistry Cal Ver/Lin 91LN1ER Chemistry Cal Ver/Lin



Cal Ver/Lin Ext Range 91U Urine Chemistry, General 58

Magnesium, ionized AQ, AQ2 Aqueous Blood Gas 73LN13C Blood Gas Cal Ver/Lin 96RRS Reference Range Service 102

Manganese R Trace Metals 63Maprotiline T Toxicology 77

UT Urine Toxicology 75MEN2 MGL3 Molecular Genetics 188Meperidine FTC Whole Blood Forensic Tox 84


Meprobamate FTC Whole Blood Forensic Tox 84T Toxicology 77UT Urine Toxicology 75

Metabolic disease testing BGL Biochemical Genetics 187

Analyte Index 231


www.cap.org


Metabolites FTC Whole Blood Forensic Tox 84T Toxicology 77UT Urine Toxicology 75

Metanephrine N Urine Chemistry, Special 59Methadone FTC Whole Blood Forensic Tox 84

T Toxicology 77UDC Forensic Urine Drug Testing,

Confirmatory 80UDS, UDS6 Urine Drug Screen 79UT Urine Toxicology 75UTCO Urine Toxicology Carry

Over 105Methadone metabolite (EDDP) FTC Whole Blood Forensic Tox 84

T Toxicology 77UDS, UDS6 Urine Drug Screen 79UT Urine Toxicology 75

Methamphetamine FTC Whole Blood Forensic Tox 84T Toxicology 77UDC Forensic Urine Drug Testing,

Confirmatory 80UDS, UDS6 Urine Drug Screen 79UT Urine Toxicology 75

Methanol AL1 Alcohol/Volatiles 82AL2 Serum Alcohol/Volatiles 82T Toxicology 77UT Urine Toxicology 75

Methaqualone UDC Forensic Urine Drug Testing, Confirmatory 80

UDS, UDS6 Urine Drug Screen 79Methemoglobin SO Blood Oximetry 74Methotrexate CZ, CZ2, Chemistry and TDM 47

CZ2X, CZX, ZMethylenedioxyamphetamine FTC Whole Blood Forensic Tox 84


Confirmatory 80UT Urine Toxicology 75

Methylenedioxymethamphetamine FTC Whole Blood Forensic Tox 84T Toxicology 77UDC Forensic Urine Drug Testing,


Methylenetetrahydrofolate MGL1 Molecular Genetics 188 reductase (MTHFR)Microsatellite instability MSI Microsatellite Instability 191Microtiter plate reader linearity I Instrumentation 104

Minimal residual disease MRD Minimal Residual Disease 191Mirtazapine T Toxicology 77Mitochondrial DNA, forensic DNA, DNAF DNA Database 213

FIDM Forensic Identity 216Mixing Studies, PT CGE, CGEX Coagulation, Extended 124Mixing Studies, APTT CGE, CGEX Coagulation, Extended 124

CGS1 Coag Special, Series 1 125Modified acid fast stain P, P3, P4, P5 Parasitology 140Mold identification F Mycology 138Molecular genetics MGL1, MGL2, Molecular Genetics 188

MGL3, MGL4,MGL5

Molecular HLA typing DL, DML, ML HLA Molecular Typing 179Molecular microbiology D8 Group B Strep 133

HBVL, HCVN, Hepatitis Viral Load 147HCV2HC6, HC6X C. trachomatis/GC

by Nucleic Acid Amp 146HIV, HV2 HIV Viral Load 147ID1, ID1T Nucleic Acid Amp, Viruses 149ID2 Nucleic Acid Amp,

Respiratory 150IDO Nucleic Acid Amp,

Organisms 149MRS, MRS5 Methicillin Resistant

S. aureus 133VLS Viral Load 148

Molecular oncology MO, MO2 Molecular Oncology 189Molecular oncology MO3 Molecular Oncology 189(paraffin sections)Monitoring engraftment ME Monitoring Engraftment 182Mononuclear cell count CBT Cord Blood Testing 164

SCP Stem Cell Processing 169Morphine FTC Whole Blood Forensic Tox 84



M-protein (paraprotein) SPE Protein Electrophoresis 56identificationMRSA MRS, MRS5 Methicillin Resistant

S. aureus 133IDO Nucleic Acid Amp,

Organisms 149Mucopolysaccharides BGL Biochemical Genetics 187Multiple endocrine neoplasia MGL3 Molecular Genetics 188 type 2 (MEN 2)Mumps - IgG VR3M Virology 144

232 Analyte Index




Mycobacterial culture E1 Mycobacteriology, Ltd 137Mycobacterial identification E Mycobacteriology 137Mycobacterium tuberculosis QF M. tuberculosis Infection 161 Ab detectionMycophenolic acid MPA Mycophenolic Acid 50Mycoplasma pneumoniae IDO Nucleic Acid Amp,

Organisms 149Mycoplasma pneumoniae VR3 Virology 144 antibody detectionMyoglobin CARM, CRT, Cardiac Markers 54

CRTIPCARM Plasma Cardiac Markers 53LN33 Serum Myoglobin

Cal Ver/Lin 102Myoglobin, urine MYG Myoglobin, Urine 59Myotonic dystrophy MGL2 Molecular Genetics 188N-acetylprocainamide (NAPA) CZ, CZ2, Chemistry and TDM 47

CZ2X, CZX, ZLN3 TDM Cal Ver/Lin 92T Toxicology 77UT Urine Toxicology 75

N. gonorrhoeae culture D3 Throat, Urine, GC Cultures 131D4 Bacteriology, Ltd 132

N. gonorrhoeae/DNA probe HC5 C. trachomatis/GC by DNA Probe 146

N. gonorrhoeae/NAA HC6, HC6X C. trachomatis/GC by Nucleic Acid Amp 146

Naproxen T Toxicology 77UT Urine Toxicology 75

Nasal smears CMM, CMMP Clinical Microscopy 117Nefazodone T Toxicology 77Neoplastic disorder by FISH CYF Fluorescence In situ

hybridization 184Neuropathology NP, NP1 Neuropathology Program 205Nicotine T Toxicology 77

UT Urine Toxicology 75Nitrite CM, CMP Clinical Microscopy 115Nitrogen, total U Urine Chemistry, General 58Non-gynecologic cytopathology NGC, NGC1 Interlab Comparison Prgm 202Norchlordiazepoxide T Toxicology 77

UT Urine Toxicology 75Norcyclobenzaprine T Toxicology 77

UT Urine Toxicology 75Norcodeine T Toxicology 77

UDC Forensic Urine Drug Testing,Confirmatory 80

UT Urine Toxicology 75

Nordiazepam FTC Whole Blood Forensic Tox 84T Toxicology 77UDC Forensic Urine Drug


Nordoxepin FTC Whole Blood Forensic Tox 84T Toxicology 77UT Urine Toxicology 75

Norepinephrine N Urine Chemistry, Special 59Norfentanyl T Toxicology 77Norfluoxetine FTC Whole Blood Forensic Tox 84Normeperidine T Toxicology 77

UT Urine Toxicology 75Norovirus SP1 Norovirus 136Norpropoxyphene FTC Whole Blood Forensic Tox 84



Norsertraline T Toxicology 77UT Urine Toxicology 75

Nortriptyline FTC Whole Blood Forensic Tox 84T Toxicology 77UT Urine Toxicology 75ZT, ZZT TDM, Special 50

Norverapamil T Toxicology 77nRBC FH3, FH3K, Hematology, Auto Diff 108

FH3P, FH9, FH9K, FH9P

NT-pro B-type natriuretic peptides BNP BNP 55LN30 BNP Cal Ver/Lin 101RRS2 Reference Range Service 102

N-telopeptide (NTX) BU Bone and Mineral, Urine 70Nucleated cells, total CBT Cord Blood Testing 164

SCP Stem Cell Processing 169Nucleated red cells, total CBT Cord Blood Testing 164

SCP Stem Cell Processing 169Nucleated red blood cell count FH3, FH3K, Hematology, Auto Diff 108

FH3P, FH9, FH9K, FH9P

Nucleic acid amplification HC6, HC6X C. trachomatis/GC by Nucleic Acid Amp 146

HBVL, HCVN, Hepatitis Viral Load 147HCV2HIV, HV2 HIV Viral Load 147IDO Nucleic Acid Amp,

Organisms 149

Analyte Index 233


www.cap.org


Nucleic acid amplification (cont.) ID1, ID1T Nucleic Acid Amp, Viruses 149ID2 Nucleic Acid Amp, Resp 150MRS, MRS5 Methicillin Resistant

S. aureus 133SP, SP1 Stool Pathogens 136VLS Viral Load 148

Nucleic acid testing NAT Nucleic Acid Testing 175Occult blood OCB Occult Blood 118Occult blood, gastric GOCB Gastric Occult Blood 119Ocular micrometer check I Instrumentation 104Olanzapine T Toxicology 77Oligoclonal bands M CSF Chemistry 62Opiate group T Toxicology 77

UDS, UDS6 Urine Drug Screen 79UT Urine Toxicology 75UTCO Urine Toxicology Carry

Over 105Organic acids BGL Biochemical Genetics 187Osmolality C3, C3X, CZ, Chemistry and TDM 47

CZ2, CZ2X, CZXCM, CMP Clinical Microscopy 115IFS Interfering Substances 106LN1 Chemistry Cal Ver/Lin 91LN1ER Chemistry Cal Ver/Lin Ext



Cal Ver/Lin Ext Range 91LN6 Urine Chemistry Cal Ver/Lin 93SW1, SW2, Sweat Analysis Series 64 SW3, SW4U Urine Chemistry, General 58

Osmometer check I Instrumentation 104Osteocalcin BGS Bone and Growth 70Oxaprozin T Toxicology 77Oxazepam FTC Whole Blood Forensic Tox 84



Oxycodone FTC Whole Blood Forensic Tox 84T Toxicology 77UDC Forensic Urine Drug Testing,


Oxyhemoglobin SO Blood Oximetry 74Oxymorphone T Toxicology 77

UDC Forensic Drug Testing 80UT Urine Toxicology 75

Pancreatic amylase C3, C3X, CZ, Chemistry and TDM 47CZ2, CZ2X, CZX

Parainfluenza antigen VR2 Virology by DFA 143Parainfluenza viruses VR1 Virology Culture 143

ID2 Nucleic Acid Amp, Resp 150Paraprotein identification SPE Protein Electrophoresis 56Parasite identification BP Blood Parasite 114

P, P3, P4, P5 Parasitology 140Parathyroid hormone (PTH) ING Insulin, Gastrin, C-Peptide,

PTH 71Parentage/relationship testing PAR, PARF Parentage/Relationship 176Paroxetine FTC Whole Blood Forensic Tox 84Parvovirus B19 ID1 Nucleic Acid Amp, Viruses 149PCO2 AQ, AQ2 Aqueous Blood Gas 73

LN13, LN13C Blood Gas Cal Ver/Lin 96O, Q Fluorocarbon Blood Gas 73

PCR (Polymerase chain reaction) D8 Group B Strep 133testing

HC6, HC6X C. trachomatis/GC by Nucleic Acid Amp 146

HCV2, HCVN Hepatitis Viral Load 147HIV, HV2 HIV Viral Load 147ID1 Nucleic Acid Amp, Viruses 149ID2 Nucleic Acid Amp, Resp 150HV2 HIV Viral Load 147ID1T Nucleic Acid Amp,

JC and BK 149IDO Nucleic Acid Amp,

Organisms 149MGL1, MGL2, Molecular Genetics 188MGL3, MGL4, MGL5MRS, MRS5 Methicillin Resistant

S. aureus 133PAR, PARF Parentage/Relationship 176SP, SP1 Stool Pathogens 136

Pentazocine T Toxicology 77UT Urine Toxicology 75

Pentobarbital T Toxicology 77UT Urine Toxicology 75

Performance Improvement PIP Performance ImprovementProgram in Surgical Pathology Program 193pH AFL Amniotic Fluid Leakage 113

234 Analyte Index




pH (cont.) AQ, AQ2 Aqueous Blood Gas 73CM, CMP Clinical Microscopy 115FLD Body Fluid 62LN13, LN13C Blood Gas Cal Ver/Lin 96O, Q Fluorocarbon Blood Gas 73UDC Forensic Urine Drug

Testing, Confirmatory 80pH meters I Instrumentation 104Phencyclidine FTC Whole Blood Forensic Tox 84


Testing, Confirmatory 80UDS, UDS6 Urine Drug Screen 79UT Urine Toxicology 75

Phenethylamine UT Urine Toxicology 75Pheniramines T Toxicology 77

UT Urine Toxicology 75Phenobarbital CZ, CZ2, Chemistry and TDM 47

CZ2X, CZX, ZFTC Whole Blood Forensic Tox 84LN3 TDM Cal Ver/Lin 92T Toxicology 77UDC Forensic Urine Drug


Phentermine FTC Whole Blood Forensic Tox 84T Toxicology 77UT Urine Toxicology 75

Phenylpropanolamine T Toxicology 77UT Urine Toxicology 75

Phenytoin CZ, CZ2, Chemistry and TDM 47CZ2X, CZX, ZFTC Whole Blood Forensic Tox 84LN3 TDM Cal Ver/Lin 92SCO Serum Carry Over 105T Toxicology 77UT Urine Toxicology 75

Phenytoin, free CZ, CZ2, Chemistry and TDM 47 CZ2X, CZX, Z

Phosphatidylglycerol (PG) LM, LM1 Lung Maturity 61Phosphorus C3, C3X, CZ, Chemistry and TDM 47

CZX, CZ2, CZ2XCFS Commutable Frozen Serum 86IFS Interfering Substances 106LN1 Chemistry Cal Ver/Lin 91

Phosphorus (cont.) LN1ER Chemistry Cal Ver/Lin Ext Range 91

LN2 Chemistry/Lipid/Enzyme Cal Ver/Lin 91

LN2ER Chemistry/Lipid/Enzyme Cal Ver/Lin Ext Range 91

LN6 Urine Chemistry Cal Ver/Lin 93RRS Reference Range Service 102U Urine Chemistry, General 58

Pinworm prep CMM, CMMP Clinical Microscopy 117Pipette calibration-gravimetric I Instrumentation 104Placental Alpha Microglobulin-1 ROM Rupture of Fetal Membranes 113(PAMG-1)Plasma hemogloblin PHG Plasma Hemoglobin 65Platelet aggregation PF Platelet Function 127Platelet antibody detection PS Platelet Serology 168Platelet count FH1-FH4, FH6, Hematology, Auto Diff 108

FH8-FH10, FH1K-FH4K, FH6K, FH8K-FH10K, FH1P-FH4P, FH6P, FH8P-FH10PHE, HEK, HEP Basic Hematology 107LN9 Hematology Cal Ver/Lin 94LN9ER Hematology Cal Ver/Lin,

Ext Range 94RRS4 Reference Range Service 103

Platelet count (Platelet-rich TRC Transfusion-Related Cell plasma) Count 170Platelet crossmatch PS Platelet Serology 168Platelet function PF1 Platelet Function 127PNH immunophenotype PNH Paroxysmal Nocturnal

Hemoglobinuria 160PNHW Paroxysmal Nocturnal

Hemoglobinuria 160PO2 AQ, AQ2 Aqueous Blood Gas 73

LN13, LN13C Blood Gas Cal Ver/Lin 96O, Q Fluorocarbon Blood Gas 73

Potassium AQ, AQ2 Aqueous Blood Gas 73C1, C3, C3X, Chemistry and TDM 47CZ, CZX, CZ2,CZ2XCFS Commutable Frozen Serum 86IFS Interfering Substances 106LN1 Chemistry Cal Ver/Lin 91LN1ER Chemistry Cal Ver/Lin Ext


Cal Ver/Lin 91

Analyte Index 235


www.cap.org


Potassium (cont.) LN2ER Chemistry/Lipid/Enzyme Cal Ver/Lin Ext Range 91

LN6 Urine Chemistry Cal Ver/Lin 93LN13C Blood Gas Cal Ver/Lin 96Q Fluorocarbon Blood Gas 73RRS2 Reference Range Service 102U Urine Chemistry, General 58

PRA MX1B, MX1C, HLA Analysis, Class I 180MX1EMX1B, MX1C, HLA Analysis, Class II 181MX1E

Prader-Willi/Angelman Syndrome MGL1 Molecular Genetics 188Prealbumin (transthyretin) C3, C3X, CZ, Chemistry and TDM 47

CZX, CZ2, CZ2XS2 Immunology, Special 153S4 Immunology, Special 153

Predictive markers by PM1 CD117 by Immunohisto-immunohistochemistry chemistry 199

PM2 ER, PR by Immunohisto-chemistry 199

PM3 CD20 by Immunohisto-chemistry 199

PM4 EGFR by Immunohisto-chemistry 199

Primidone CZ, CZX, CZ2, CZ2X, Z Chemistry and TDM 47LN3 TDM Cal Ver/Lin 92

Pro B-type natriuretic peptides RRS2 Reference Range Service 102Procainamide CZ, CZX, CZ2,

CZ2X, Z Chemistry and TDM 47LN3 TDM Cal Ver/Lin 92T Toxicology 77UT Urine Toxicology 75

Progesterone LN8 Reproductive EndocrinologyCal Ver/Lin 94

Y, YY Ligand Assay, Special 69Prolactin LN8 Reproductive Endocrinology

Cal Ver/Lin 94Y, YY Ligand Assay, Special 69

Propoxyphene FTC Whole Blood Forensic Tox 84T Toxicology 77UDC Forensic Urine Drug

Testing, Confirmatory 80UDS, UDS6 Urine Drug Screen 79UT Urine Toxicology 75UTCO Urine Toxicology Carry Over 105

Prostate-specific antigen (PSA) K, KK Ligand Assay, General 67LN23 PSA Cal Ver/Lin 99RRS3 Reference Range Service 103

Prostate-specific antigen, K, KK Ligand Assay, General 67 complex (cPSA)Prostate-specific antigen, free K, KK Ligand Assay, General 67(PSA, free)Prostate-specific antigen, ratio K, KK Ligand Assay, General 67Prostatic acid phosphatase (PAP) K, KK Ligand Assay, General 67Protein electrophoresis SPE Protein Electrophoresis 56Protein C CGE, CGEX Coagulation, Extended 124

CGS2 Coag Special, Series 2 125Protein S CGE, CGEX Coagulation, Extended 124

CGEX Coagulation, Extended 124CGS2 Coag Special, Series 2 125

Protein, total C1, C3, C3X, Chemistry and TDM 47CZ, CZX, CZ2, CZ2XCFS Commutable Frozen Serum 86FLD Body Fluid 62IFS Interfering Substances 106LN1 Chemistry Cal Ver/Lin 91LN1ER Chemistry Cal Ver/Lin Ext



Cal Ver/Lin Ext Range 91LN6 Urine Chemistry Cal Ver/Lin 93M CSF Chemistry 62RRS Reference Range Service 102SPE Lipoprotein and Protein

Electrophoresis 56U Urine Chemistry, General 58VMC Viral Marker Chemistry 169

Protein, urine CM Clinical Microscopy 115CMP Clinical Microscopy 115U Urine Chemistry, General 58

Prothrombin MGL1 Molecular Genetics 188Prothrombin time CGL Coagulation, Ltd 123

CGS1 Coag Special, Series 1 125CGS4 Coag Special, Series 4 125WP3, WP4, Whole Blood, Coagulation 126WP6, WP7, WP9WP8 Whole Blood Coagulation,

Waived 126Provider-performed microscopy CMM, CMMP Clinical Microscopy 117Pseudocholinesterase C7 Pseudocholinesterase 56Pseudoephedrine FTC Whole Blood Forensic Tox 84

T Toxicology 77

236 Analyte Index




Pseudoephedrine (cont.) UT Urine Toxicology 75PVA slide P, P4 Parasitology 140Pyridinoline (PYD) BU Bone and Mineral, Urine 70Pyrilamine T Toxicology 77Q-PROBES QP091 Quality Management Tools 35

QP092 Quality Management Tools 36QP093 Quality Management Tools 37QP094 Quality Management Tools 37

Q-TRACKS QT1-4, 5 Quality Management Tools 28- 29, 33

QT7-10 Quality Management Tools 30- 31

QT15-17 Quality Management Tools 32- 33

Quetiapine T Toxicology 77Quinidine CZ, CZX, CZ2, Chemistry and TDM 47

CZ2X, ZLN3 TDM Cal Ver/Lin 92T Toxicology 77UT Urine Toxicology 75

Quinine T Toxicology 77UT Urine Toxicology 75

Ranitidine T Toxicology 77UT Urine Toxicology 75

Rapamycin (sirolimus) CS Immunosuppressive Drugs 50Rapid Group A Strep D Bacteriology 130

D4 Bacteriology, Ltd 132D6 Rapid Group A Strep 132D9 Rapid Group A Strep,

Waived 134RBC count ABF1, ABF2, Automated Body Fluid 120

ABF3FH1-FH4, FH6, Hematology, Auto Diff 108FH8-FH10, FH1K-FH4K, FH6K, FH8K-FH10K, FH1P-FH4P, FH6P, FH8P-FH10PHE, HEK, HEP Basic Hematology 107LN9 Hematology Cal Ver/Lin 94RRS4 Reference Range Service 103UAA, UAA1 Automated Urinalysis 116HFC Hemocytometer Fluid

Count 119RBC folate FOL RBC Folate 68Red blood cell antigen detection J, J1 Transfusion Medicine 163

PAR Parentage/Relationship 176

Reducing substance CM, CMP Clinical Microscopy 115Refractometer check I Instrumentation 104Renin RAP Renin and Aldosterone 71Reticulocyte count RT, RT2, RT3, Reticulocyte 110

RT4LN18 Reticulocyte Cal Ver/Lin 98LN19 Reticulocyte Cal Ver/Lin 98

RhD MGL2 Molecular Genetics 188RhD typing J, J1 Transfusion Medicine 163

JAT Transfusion Medicine, Automated 165


Rheumatoid factor IL, RF, RFX Immunology 151Rhinovirus ID2 Nucleic Acid Amp, Resp 150Rotavirus SP Stool Pathogens 136

VR4 Virology Ag 144RSV ID2 Nucleic Acid Amp, Resp 150

VR1 Virology Culture 143VR2 Virology by DFA 143VR4 Virology Ag 144

Rubella antibody IL, RUB, Immunology 151RUBX

Rubeola antibody VR3 Virology 144Salicylate CZ, CZX, CZ2, Chemistry and TDM 47

CZ2X, ZLN3 TDM Cal Ver/Lin 92SDS Serum Drug Screen 81T Toxicology 77UT Urine Toxicology 75

Sarcoma by FISH CYK Fluorescence in situ hybridization 186

Sarcoma translocation SARC Sarcoma Translocation 191Scl-70 (anti-DNA topoisomerase) RDS Rheumatic Disease Special 156Secobarbital FTC Whole Blood Forensic Tox 84



Selenium R Trace Metals 63Semen analysis ASA, SC, SC1, Semen Analysis 121

SM, SVSMCD, Semen Analysis, CD-ROM 121SM1CD

Sertraline FTC Whole Blood Forensic Tox 84T Toxicology 77UT Urine Toxicology 75

Analyte Index 237


www.cap.org


Sex hormone-binding globulin DY Ligand Assay, Special 69 (SHBG)Shiga Toxin ST Shiga Toxin 133Sickling test HG Hemoglobinopathy 112

SCS Sickle Cell Screen 112Sirolimus (Rapamycin) CS Immunosuppressive Drugs 50Sodium AQ, AQ2 Aqueous Blood Gas 73

C1, C3, C3X, Chemistry and TDM 47CZ, CZ2, CZ2X, CZXIFS Interfering Substances 106LN1 Chemistry Cal Ver/Lin 91LN1ER Chemistry Cal Ver/Lin Ext



Cal Ver/Lin Ext Range 91LN6 Urine Chemistry Cal Ver/Lin 93LN13C Blood Gas Cal Ver/Lin 96Q Fluorocarbon Blood Gas 73RRS2 Reference Range Service 102SW1, SW2, Sweat Analysis Series 64 SW3, SW4U Urine Chemistry, General 58

Somatomedin C (IGF-1) Y, YY Ligand Assay, Special 69Specific gravity CM Clinical Microscopy 115

CMP Clinical Microscopy 115UDC Forensic Urine Drug

Testing, Confirmatory 80Spectrophotometer linearity I Instrumentation 104Sperm count SC, SC1 Semen Analysis 121

SMCD Semen Analysis, CD-ROM 121Sperm morphology SM Semen Analysis 121

SM1CD Semen Analysis, CD-ROM 121Sperm motility SMCD Semen Analysis, CD-ROM 121Sperm viability SV Semen Analysis 121Spinal fluid meningitis panel D Bacteriology 130Spinal muscular atrophy MGL2 Molecular Genetics 188Spinocerebellar ataxia MGL2 Molecular Genetics 188Streptococcus pneumoniae BAS Bacterial Antigen Detection 134Strychnine UT Urine Toxicology 75

T Toxicology 77Sulfosalicylic acid (SSA) DSC Dipstick Confirmatory 116Surgical pathology PIP, PIP1 Performance Improvement

Program in Surgical Pathology 193

Surgical pathology (cont.) VBP, VBP1 Online Virtual Biopsies Program 194

DPATH, Online Digital SlideDPATH1 Program 195

Syphilis G Syphilis Serology 158T3, free C1, C3, C3X, Chemistry and TDM 47

CZ, CZX, CZ2, CZ2XK, KK Ligand Assay, General 67

T3, total (triiodothyronine) C1, C3, C3X, Chemistry and TDM 4CZ, CZX, CZ2, CZ2XK, KK Ligand Assay, General 67LN5 Ligand Assay Cal Ver/Lin 92

T3 uptake & related tests C1, C3, C3X, Chemistry and TDM 47CZ, CZX, CZ2, CZ2XK, KK Ligand Assay, General 67

T4, free (thyroxine, free) C1, C3, C3X, Chemistry and TDM 47CZ, CZX, CZ2, CZ2XK, KK Ligand Assay, General 67

T4, total (thyroxine, total) C1, C3, C3X, Chemistry and TDM 47CZ, CZX, CZ2, CZ2XCFS Commutable Frozen Serum 86K, KK Ligand Assay, General 67LN5 Ligand Assay Cal Ver/Lin 92RRS Reference Range Service 102

Tacrolimus CS Immunosuppressive Drugs 50LN31 Immunosuppressive Drugs

Cal Ver/Lin 101Tay Sachs MGL4 Molecular Genetics 188tCO2 AQ, AQ2 Aqueous Blood Gas 73Temazepam FTC Whole Blood Forensic Tox 84

UDC Forensic Urine Drug Testing, Confirmatory 80


Testosterone LN8 Reproductive Endocrino-logy Cal Ver/Lin 94

RRS2 Reference Range Service 102Y, YY Ligand Assay, Special 69

Testosterone, bioavailable DY Ligand Assay, Special 69Testosterone, free DY Ligand Assay, Special 69Theophylline CZ, CZX, CZ2, Chemistry and TDM 47

CZ2X, ZLN3 TDM Cal Ver/Lin 92T Toxicology 77UT Urine Toxicology 75

238 Analyte Index




Thioridazine T Toxicology 77Throat culture D1, D7 Throat, Urine, GC Cultures 131

D4 Bacteriology, Ltd 132Thrombin time CGE Coagulation, Extended 124

CGEX Coagulation, Extended 124CGS4 Coag Special, Series 4 125RRS2 Reference Range Service 102

Thromboelastogram TEG Thromboelastogram 127Thyroglobulin TM, TMX Tumor Markers 68Thyroid-stimulating hormone C1, C3, C3X, Chemistry and TDM 47(TSH) CZ, CZX, CZ2,

CZ2X K, KK Ligand Assay, General 67LN5 Ligand Assay Cal Ver/Lin 92RRS Reference Range Service 102

Tissue parasite identification BP Blood Parasite 114P Parasitology 140

Tobramycin CZ, CZX, CZ2, Chemistry and TDM 47CZ2X, ZLN3 TDM Cal Ver/Lin 92

Total bilirubin C1, C3, C3X, Chemistry and TDM 47CZ, CZX, CZ2, CZ2XCM, CMP Clinical Microscopy 115IFS Interfering Substances 106LM1 Lung Maturity 61LN1 Chemistry Cal Ver/Lin 91LN1ER Chemistry Cal Ver/Lin



Cal Ver/Lin Ext Range 91NB, NB2 Neonatal Bilirubin 63

Total Hemolytic Complement CH50 Total Hemolytic Complement 152

Total iron binding capacity and C3, C3X, CZ, Chemistry and TDM 47% saturation CZX, CZ2,

CZ2XRRS Reference Range Service 102

Total nitrogen U Urine Chemistry, General 58Total nucleated cells CBT Cord Blood Testing 164

SCP Stem Cell Processing 169Total nucleated red cells CBT Cord Blood Testing 164

SCP Stem Cell Processing 169Total protein C1, C3, C3X, Chemistry and TDM 47

CZ, CZX, CZ2, CZ2X

Total protein (cont.) CFS Commutable Frozen Serum 86FLD Body Fluid 62IFS Interfering Substances 106LN1 Chemistry Cal Ver/Lin 91LN1ER Chemistry Cal Ver/Lin



Cal Ver/Lin Ext Range 91LN6 Urine Chemistry Cal Ver/Lin 93M CSF Chemistry 62RRS Reference Range Service 102SPE Protein Electrophoresis 56U Urine Chemistry, General 58VMC Viral Marker Chemistry 169

Total tricyclics SDS Serum Drug Screen 81ZT TDM, Special 50ZZT TDM, Special 50

Toxoplasma gondii antibody VR3 Virology 144Tramadol FTC Whole Blood Forensic Tox 84


Transferrin C3, C3X, CZ, Chemistry and TDM 47CZX, CZ2, CZ2XLN7 Immunology Cal Ver/Lin 93S2, S4 Immunology, Special 153

Transfusion medicine J, J1 Transfusion Medicine 163JAT Transfusion Medicine,

Automated 165JE1 Transfusion Medicine,

Education 166TMCA Transfusion Medicine,

Competency Assessment 166TMCAD Transfusion Medicine,

Competency Assessment 167TMCAF Transfusion Medicine,

Competency Assessment 168TRC Transfusion-Related Cell

Count 170Trazodone FTC Whole Blood Forensic Tox 84


Trichloroethanol T Toxicology 77Trichomonas vaginalis VS VS1 Vaginitis Screen Ag 135Tricyclic group T Toxicology 77

UDS, UDS6 Urine Drug Screen 79

Analyte Index 239


www.cap.org


Tricyclics, total SDS Serum Drug Screen 81ZT, ZZT TDM, Special 50

Triglycerides ABL Accuracy Based Lipid 88C1, C3, C3X, Chemistry and TDM 47CZ, CZX, CZ2, CZ2XFLD Body Fluid 62LCW Ltd Chem, Waived 52LN2 Chemistry/Lipid/Enzyme


Cal Ver/Lin Ext Range 91Triiodothyronine (T3) C1, C3, C3X, Chemistry and TDM 47

CZ, CZX, CZ2, CZ2XK, KK Ligand Assay, General 67LN5 Ligand Assay Cal Ver/Lin 92

Trimipramine T Toxicology 77Tripelennamine T Toxicology 77

UT Urine Toxicology 75Troponin I PCARM Plasma Cardiac Markers 53

RRS3 Reference Range Service 103Troponins I and T CRT, CRTI Cardiac Markers 54

LN25 Troponin I Cal Ver/Lin 100LN27 Troponin T Cal Ver/Lin 100TRP Cardiac Markers 54

UGT1A1 PGX Pharmacogenetics 187Unsaturated Iron Binding Capacity C3, C3X, CZ, Chemistry and TDM 47

CZX, CZ2, CZ2X

Urea nitrogen AQ2 Aqueous Blood Gas 73C1, C3, C3X, Chemistry and TDM 47CZ, CZX, CZ2, CZ2XCFS Commutable Frozen Serum 86IFS Interfering Substances 106LN1 Chemistry Cal Ver/Lin 91LN1ER Chemistry Cal Ver/Lin



Cal Ver/Lin Ext Range 91LN6 Urine Chemistry Cal Ver/Lin 93RRS2 Reference Range Service 102U Urine Chemistry, General 58

Urease RUR Rapid Urease 135Uric acid C1, C3, C3X, Chemistry and TDM 47

CZ, CZX, CZ2, CZ2X

Uric acid (cont.) CFS Commutable Frozen Serum 86IFS Interfering Substances 106LN1 Chemistry Cal Ver/Lin 91LN1ER Chemistry Cal Ver/Lin Ext



Cal Ver/Lin Ext Range 91LN6 Urine Chemistry Cal Ver/Lin 93RRS2 Reference Range Service 102U Urine Chemistry, General 58

Urine albumin LN20 Urine albumin Cal Ver/Lin 98U Urine Chemistry, General 58UMC Urine albumin/Creatinine 116

Urine albumin/creatinine ratio U Urine Chemistry, General 58Urine crystals URC Crystals 117Urine culture D2, D7 Throat, Urine, GC Cultures 131

D4 Bacteriology, Ltd 132Urine sediment, photomicrographs CM Clinical Microscopy 115Urine sediment, color photographs CMP Clinical Microscopy 115Urobilinogen CM, CMP Clinical Microscopy 115Uroporphyrin N Urine Chemistry, Special 59Urothelial carcinoma surveillance CYI Fluorescence in situby FISH hybridization 184Vaginal wet preperations CMM, CMMP Clinical Microscopy 117Valproic acid CZ, CZX, CZ2, Chemistry and TDM 47

CZ2X, ZLN3 TDM Cal Ver/Lin 92T Toxicology 77

Valproic acid, free CZ, CZX, CZ2, Chemistry and TDM 47 CZ2X, Z

Vancomycin LN3 TDM Cal Ver/Lin 92CZ, CZX, CZ2, Chemistry and TDM 47CZ2X, Z

Vancomycin resistant IDO Nucleic Acid Amp,Enterococcus Organisms 149Vanillylmandelic acid N Urine Chemistry, Special 59Varicella-zoster virus VR1 Virology Culture 143

VR2 Virology by DFA 143VR3 Virology 144

Verapamil T Toxicology 77UT Urine Toxicology 75

Viability CBT Cord Blood Testing 164SCP Stem Cell Processing 169

Viral antibody detection VR3 Virology 144Viral antigen detection HC2 HSV by DFA 146

240 Analyte Index




Viral antigen detection (cont.) VR2 Virology by DFA 143VR4 Virology Ag 144

Viral isolation/identification HC4 HSV Culture 146VR1 Virology Culture 143

Virtual biopsy program, online VBP, VBP1 Online Virtual Biopsies Program 194

Viscosity V Viscosity 56Vitamin B12 K, KK Ligand Assay, General 67

LN5 Ligand Assay Cal Ver/Lin 92RRS2 Reference Range Service 102

VKORC1 PGX Pharmacogenetics 187Volatiles AL1 Alcohol/Volatiles 82

AL2 Serum Alcohol/Volatiles 82T Toxicology 77UDS, UDS6 Urine Drug Screen 79UT Urine Toxicology 75

von Willebrand factor CGE, CGEX Coagulation, Extended 124CGS3 Coag Special, Series 3 125

Wavelength and photometric I Instrumentation 104 calibrationWBC count ABF1, ABF2, Automated Body Fluid 120

ABF3CBT Cord Blood Testing 164FH1-FH4, Hematology, Auto Diff 108FH6, FH8-FH10, FH1K-FH4K, FH6K, FH8K-FH10K, FH1P-FH4P, FH6P, FH8P-FH10P

HE, HEK, HEP Basic Hematology 107LN9 Hematology Cal Ver/Lin 94LN9ER Hematology Cal Ver/Lin 94RRS4 Reference Range Service 103SCP Stem Cell Processing 169UAA, UAA1 Automated Urinalysis 116HFC Hemocytometer Fluid

Count 119WBC count (leukocyte-reduced TRC Transfusion-Related Cell platelets) Count 170WBC count (leukocyte-reduced TRC Transfusion-Related Cel RBCs) Count 170WBC differential FH1-FH4, FH6, Hematology, Auto Diff 108

FH8-FH10, FH1K-FH4K, FH6K, FH8K-FH10K, FH1P-FH4P, FH6P, FH8P-FH10P

West Nile virus antigen NAT Nucleic Acid Testing 175Yeast identification F Mycology 138

F1 Yeast 138Zinc R Trace Metals 63Zolpidem T Toxicology 77

Analyte Index 241


www.cap.org


LNLNExpress CAPHas

CreatedTools to

HelpYou

ManageYour

Workload

Alerts you that your PT products have shipped, resulting in less worries.

Designed to assist laboratories establish and/or verify reference intervals.Data collection and analysis follows recommendations specified in CLSI’sdocument, Defining, Establishing, and Verifying Reference Intervals in theClinical Laboratory; Proposed Guideline—Third Edition (C28-P3).

! Saves valuable time, getting results up to 10 days sooner! Minimizes PT failure with pre-populated electrnic forms and drop

down menus! Eliminates clerical errors due to scanning or faxing! Manages your workload with timely e-mail reminders for data

submission and result reporting

Within four days of input, you can access your time critical evaluation ofLinearity Reports, utilizing e-LAB SolutionsTM.

Designed to provide ongoing information about Proficiency Testing (PT),the Laboratory Accreditation Program (LAP), and the education divisions ofthe College of American Pathologists. The newsletter will be available forreview on the CAP Web site by selecting the Accreditation and LaboratoryImprovement tab.

A tool designed to provide regulatory and other important informationrelative to CAP products and services that contain time-sensitive implicationsfor laboratories.

SM

Reference Range Service

23SURVEYS PRODUCT SHIPPING AND PRICING

Surv

eys

Prod

uctS

hipp

ing

and

Pric

ing

We’ve made it better and moreconvenient to use!

! Alphabetized product codeswith description, page number,price, and shipping dates all onone line

! Easy to remove and use at yourdesk as a reference tool

! Complete virtual 2009 Surveyscatalog available on the CAPWeb site at www.cap.org

2009 Surveys &

Anatomic Pathology

Education Programs

Shipping Calendar

New and Improved

2009 SURVEY Product, Shipping, and Pricing 243


www.cap.org

ABF1 ABF1 Automated Body Fluid $274 120 A 9 B 17



ABL ABL Accuracy Based Lipid $412 88 A 16-17 B 20-21

ABO HL HLA Serologic Typing (Class I / II) $198 177 A 10 B 16 C 15

ABT ABT Antibody Titer $378 171 A 1 B 5

ABT1 ABT Antibody Titer $284 171 A 1 B 5

ABT2 ABT Antibody Titer $284 171 A 1 B 5

ACE ACE Angiotensin Converting Enzyme $276 63 A 30 B 21

ACL ACL Antiphospholipid Antibody $230 157 A 16 B 2

ADL ADL Aldolase $518 55 A 18 B 19

AFL AFL Amniotic Fluid Leakage (Nitrazine) $218 113 A 11 B 14

AHIV AHIV Anti-HIV-1/2 $396 174 A 30 B 10 C 30

AHIVW AHIVW Anti-HIV-1/2, Waived $214 174 A 10 B 30

AL1 AL1 AACC/CAP Alcohol/Volatiles $324 82 A 23 B 8 C 28

AL2 AL2 AACC/CAP Serum Alcohol/Volatiles $324 82 A 2 B 1 C 5

AL2M AL2M AACC/CAP Serum Alcohol/Volatiles VM $261 82 A 2 B 1 C 5

ANA S Immunology $150 151 A 23 B 17 C 30

APC GIH Anti-Parietal Cell Antibody $374 154 A 27 B 28

APT APT Fetal Hemoglobin $234 113 A 2 B 28

AQ AQ Critical Care Aqueous and Fluorocarbon

Blood Gas $462 73 A 9 B 8 C 12

AQ2 AQ Critical Care Aqueous and Fluorocarbon

Blood Gas $534 73 A 9 B 8 C 12

ASA SEM Semen Analysis $234 121 A 20 B 26

ASC ASC Anti-Saccharomyces cerevisiae Antibody $362 155 A 11 B 7

ASO S Immunology $150 151 A 23 B 17 C 30

AU AU Autopsy Pathology $406 206 A 5 B 20

AU1 AU Autopsy Pathology $54 206 A 5 B 20

AUCD AUCD Autopsy Pathology on CD-ROM $320 206 A 5 B 20

AUCD1 AUCD Autopsy Pathology on CD-ROM $54 206 A 5 B 20

B27 B27 HLA-B27 Typing $434 179 A 14 B 25

BAS BAS Bacterial Antigen Detection $154 134 A 2 B 9

BCK KP Blood Cell Identification $99 110 A 26 B 4 C 21

PROD PFG DESCRIPTION PRICE PAGE JAN FEB MAR APR MAY JUN JUL AUG SEP OCT NOV DECCODE CODE

Look for notification of kit shipment via CAP TRAKersm. If you do not receive your kit within 7–10 calendar days following theshipdate, or if you receive an incomplete or damaged shipment, please call the Customer Contact Center at 800-323-4040option 1. Requests for replacements after the 10th calendar day cannot be accepted.

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2009 SURVEYS Product Shipping and Pricing

244 2009 SURVEYS Product Shipping and Pricing



2009 SURVEYS Product Shipping and Pricing Continued

BCP KP Blood Cell Identification $33 110 A 26 B 4 C 21

BCS BCS Blood Culture $300 131 A 22 B 26

BDP BDP Bacterial Detection in Platelets $550 171 A 20 B 19

BFC CRS Body Fluid Crystals $340 117 A 8 B 12

BGL BGL ACMG/CAP Biochemical Genetics $650 187 A 10 B 18

BGS Y Bone and Growth $494 70 A 27 B 21

BL BL AACC/CAP Blood Lead $621 83 A 16 B 13 C 26

BLM BLM Blood Lead VM $498 83 A 16 B 13 C 26

BNP BNP B-type Natriuretic Peptides $210 55 A 9 B 29

BP BP Blood Parasite $459 114 A 26 B 18 C 21

BU Y Bone and Mineral Metabolism, Urine $470 70 A 27 B 21

C1 C General Chemistry and Therapeutic Drugs $330 47 A 2 B 1 C 5

C3 C General Chemistry and Therapeutic Drugs $381 47 A 2 B 1 C 5

C3X C General Chemistry and Therapeutic Drugs $438 47 A 2 B 1 C 5

C7 C Pseudocholinesterase $159 56 A 2 B 1 C 5

CARM CAR Cardiac Markers $213 54 A 3 B 2 C 6

CARMI CARI Cardiac Markers $318 54 A 3 B 2 C 6

CBT CBT Cord Blood Testing $650 164 A* B*CCP RDS Cyclic Citrullinated Peptide Antibody (Anti-CCP) $378 156 A 18 B 2

CD CD Cadmium $1,518 83 A 5 B 30 C 1 D 3 E 21 F 23

CES CES Celiac Serology $466 157 A 9 B 14

CFS CFS Commutable Frozen Serum $190 86

CGDF CGL Coagulation, Limited, D-dimer/FDP $148 123 A 26 C 14

CGE CGE Coagulation, Extended $452 124 A 30 B 14

CGEX CGE Coagulation, Extended $734 124 A 30 B 14

CGL CGL Coagulation, Limited $219 123 A 26 B 11 C 14

CGM CGM Coagulation VM (Comprehensive) $198 123 A 26 B 11 C 14

CGS1 CGS1 Coagulation Special Testing, Series 1 $376 125 A 30 B 14




CGS5 CGS5 Coagulation Special Testing, HIT $428 125 A 14 B 20

CH50 CH50 Total Hemolytic Complement $376 151 A 21 B 3

CHPVD CHPV Human Papillomavirus for Cytology $450 204 A 30 B 3 C 14


*Product ship date subject to change.


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2009 SURVEYS Product Shipping and Pricing 245


www.cap.org


CHPVJ CHPV Human Papillomavirus for Cytology $450 204 A 30 B 3 C 14

CHPVK CHPV Human Papillomavirus for Cytology $450 204 A 30 B 3 C 14

CHPVM CHPV Human Papillomavirus for Cytology $450 204 A 30 B 3 C 14

CM CM Clinical Microscopy $250 115 A 16 B 3

CMP CM Clinical Microscopy $180 115 A 16 B 3

CMM CM Clinical Microscopy $148 117 A 16 B 3

CMMP CM Clinical Microscopy $98 117 A 16 B 3

CRP S Immunology $150 151 A 23 B 17 C 30

CRT CAR Cardiac Markers $282 54 A 3 B 2 C 6

CRTI CARI Cardiac Markers $375 54 A 3 B 2 C 6

CS CSM AACC/CAP Immunosuppressive Drugs $316 50 A 16 B 23

CT CT Activated Clotting Time $294 128 A 19 B 4

CT1 CT1 Activated Clotting Time $302 128 A 19 B 4



CY CY ACMG/CAP Cytogenetics $582 183 A 30 B 13 C 2

CYCGH CYCGH ACMG/CAP Microarray– Genomic Copy Number $526 185 A 18 B 19

CYF CYF ACMG/CAP Fluorescence In Situ Hybridization–

Constitutional and Hematologic Disorders $466 184 A 13 B 2

CYH CYH ACMG/CAP Fluorescence In Situ Hybridization–

Breast Cancer (HER2 Gene Amplification) $526 185 A 1 B 23

CYI CYI ACMG/CAP Fluorescence In Situ Hybridization–

Urothelial Carcinoma $504 184 A 23 B 3

CYJ CYP ACMG/CAP FISH for Paraffin-Embedded Tissue $552 186 A 23 B 3

CYK CYP ACMG/CAP FISH for Paraffin-Embedded Tissue $606 186 A 23 B 3

CYL CYP ACMG/CAP FISH for Paraffin-Embedded Tissue $670 186 A 23 B 3

CYM CYM ACMG/CAP Cytogenetics VM $387 183 A 30 B 13 C 2

CYS CYS Cystatin C $332 65 A 30 B 8

CZ C General Chemistry and Therapeutic Drugs $510 47 A 2 B 1 C 5

CZ2 C General Chemistry and Therapeutic Drugs $588 47 A 2 B 1 C 5

CZ2X C General Chemistry and Therapeutic Drugs $660 47 A 2 B 1 C 5

CZVM CZVM Chemistry/TDM VM $411 49 A 2 B 1 C 5

CZX C General Chemistry and Therapeutic Drugs $579 47 A 2 B 1 C 5

D D Bacteriology $318 130 A 2 B 26 C 5



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D1 D1 Throat, Urine, GC Cultures $252 131 A 30 B 10 C 30



D4 D4 Bacteriology (Limited) $297 132 A 30 B 10 C 30

D5 D5 Gram Stain $204 132 A 23 B 6 C 19

D6 D6 Rapid Strep Antigen Detection $201 132 A 9 B 10 C 14


D8 D8 Group B Strep Antigen Detection $201 133 A 27 B 13 C 30

D9 D9 Rapid Strep Antigen Detection, Waived $138 134 A 30 B 3

DAT DAT Direct Antiglobulin Testing $186 165 A 2 B 12

DL DL HLA Molecular Typing $624 179 A 17 B 7 C 29

DML ML HLA Molecular Typing $1,008 179 A 17 B 7 C 29

DNA DNA DNA Database $888 213 A 6 B 14

DNAF DNAF DNA Database $838 213 A 6 B 14

DPATH DPATH Online Dermatopathology $402 195 A 15 B 14

DPATH1 DPATH Online Dermatopathology, Addl Path $98 195 A 15 B 14

DSC CM Dipstick Confirmatory Testing $186 116 A 16 B 3

DY Y Ligands Assay (Special) $66 69 A 27 B 21

E E Mycobacteriology $420 137 A 5 B 3

E1 E1 Mycobacteriology (Limited) $372 137 A 9 B 28

ELU ELU Eluate $946 170 A 23 B 20

EMB EMB Embryology $390 122 A 8 B 26

EPO Y Erythropoietin $314 71 A 27 B 21

ESR ESR Erythrocyte Sedimentation Rate $198 111 A 18 B 8

ESR1 ESR1 Erythrocyte Sedimentation Rate $198 111 A 18 B 8

F F Mycology $450 138 A 12 B 4 C 24

F1 F1 Yeast $348 138 A 2 B 26 C 14

FCFS FCFS Fecal Fat $256 64 A 2 B 14

FF FF Fetal Fibronectin $408 72 A 8 B 26

FH1 FH1 Hematology Automated Differentials FH1 Series $300 108 A 26 B 4 C 21

FH1K FH1 Hematology Automated Differentials FH1 Series $399 108 A 26 B 4 C 21

FH1P FH1 Hematology Automated Differentials FH1 Series $333 108 A 26 B 4 C 21









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FH10 FH10 Hematology Automated Differentials

FH10 Series $300 108 A 26 B 4 C 21

FH10K FH10 Hematology Automated Differentials

FH10 Series $399 108 A 26 B 4 C 21

FH10P FH10 Hematology Automated Differentials

FH10 Series $333 108 A 26 B 4 C 21

FID FID Forensic Identity - Nuclear and Mitochondrial

DNA Analysis $918 216 A 6 B 14

FIDM FID Forensic Identity - Nuclear and Mitochondrial

DNA Analysis $808 216 A 6 B 14

FL FL Flow Cytometry $1,440 159 A 9 B 15 C 12

FL1 FL Flow Cytometry $774 159 A 9 B 15 C 12

FL2 FL Flow Cytometry $822 159 A 9 B 15 C 12

FL3 FL3 Flow Cytometry - Immunophenotypic $648 159 A 3 B 15

FL3CD FL3CD Flow Cytometry - Immunophenotypic $250 159 A 9 B 17

FL4 FL4 Flow Cytometry - CD34+ $526 160 A 13 B 19

FL5 FL5 Flow Cytometry Interpretation $226 160 A 9 B 17

FLD FLD Body Fluid Chemistry $302 62 A 16 B 3




www.cap.org



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FNA FNA Online Digital Slide Program in Fine-

Needle Aspiration $298 203 A 20 B 8

FNA1 FNA Online Digital Slide Program in Fine-

Needle Aspiration $56 203 A 20 B 8

FOL K RBC Folate $222 68 A 6 B 20 C 9

FP FP FBR/CAP Maternal Screening $678 72 A 26 B 1 C 8

FPX FP FBR/CAP Maternal Screening $774 72 A 26 B 1 C 8

FR FR Forensic Pathology $402 215 A 18 B 23

FR1 FR Forensic Pathology $54 215 A 18 B 23

FT FT Fructosamine $140 61 A 4 B 9

FTC FTC Whole Blood Forensic Toxicology $1,060 84 A 9 B 14

G G Syphilis Serology $240 158 A 13 B 10 C 7

G6PDS G6PDS Glucose-6-phosphate Dehydrogenase $268 61 A 23 B 12

GH2 GH2 Glycohemoglobin $212 60 A 7 B 10

GOCB CM Gastric Occult Blood $252 119 A 16 B 3

H GIH Antimitochondrial M2 Antibody $382 154 A 27 B 28

HBF HBF Fetal Red Cell Determination $326 113 A 27 B 2

HBVL HVL Hepatitis Viral Load $456 147 A 3 B 26 C 29

HC1 HC1 C. trachomatis Antigen Detection (DFA) $333 146 A 9 B 6 C 26

HC2 HC2 Herpes Simplex Virus Antigen Detection (DFA) $342 146 A 9 B 6 C 26

HC3 HC3 C. trachomatis Enzyme Immunoassy $345 146 A 12 B 27 C 8

HC4 HC4 Herpes Simplex Virus Culture $369 146 A 23 B 8 C 21

HC5 HC5 C. trachomatis and N. gonorrhoeae by

DNA Probe $441 146 A 12 B 27 C 8

HC6 HC6 C. trachomatis and N. gonorrhoeae by NAA $405 146 A 19 B 18 C 14

HC6X HC6 C. trachomatis and N. gonorrhoeae by NAA $609 146 A 19 B 18 C 14

HCC HCC Waived Combination $154 112 A 9 B 21

HCG S Immunology $150 151 A 23 B 17 C 30

HCV2 HVL Hepatitis Viral Load $1,410 147 A 3 B 26 C 29

HCVN HVL Hepatitis Viral Load $927 147 A 3 B 26 C 29

HE HE Basic Hematology $219 107 A 26 B 4 C 21

HEK HE Basic Hematology $300 107 A 26 B 4 C 21

HEP HE Basic Hematology $240 107 A 26 B 4 C 21

HER2 HER2 HER2 Immunohistochemistry, Tissue Microarray $748 198 A* B*




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www.cap.org


HFC HFC Hemocytometer Fluid Count $260 119 A 3 B 30

HG HG Hemoglobinopathy $482 112 A 9 B 10

HIV HIV HIV Viral Load $606 147 A 3 B 26 C 29

HLAS HL HLA Serologic Typing (Class I) $750 177 A 10 B 16 C 15

HLAS1 HL HLA Serologic Typing (Class I / II) $672 177 A 10 B 16 C 15

HMS CR Homocysteine $266 57 A 23 B 2

HPS HPS H. pylori Antigen, stool $254 135 A 30 B 14

HPV HPV Human Papillomavirus $250 150 A 22 B 19

HQIP HQIP NSH/CAP HistoQIP $568 196 A 2 B 27

hsCRP CR High Sensitivity C-reactive Protein $270 57 A 23 B 2

HV2 HIV HIV Viral Load $705 147 A 3 B 26 C 29

I I Instrumentation $498 104 A 30 B 27 C 30

ID1 ID1 Nucleic Acid Amplification, Viruses $600 149 A 13 B 19

ID1T ID1 Nucleic Acid Amplification, JC and BK $300 149 A 13 B 19

ID2 ID2 Nucleic Acid Amplification, Respiratory $530 150 A 13 B 19

IDO IDO Nucleic Acid Amplification, Organisms $500 149 A 13 B 19

IFS IFS Interfering Substances $391 106 A 8

IG S Immunology (General) $261 151 A 23 B 17 C 30

IGX S Immunology (General) $390 151 A 23 B 17 C 30

IL S Immunology $933 151 A 23 B 17 C 30

IM S Immunology $150 151 A 23 B 17 C 30

IMW IMW Infectious Mononucleosis, Waived $98 151 A 30 B 10

IND IND India Ink $166 139 A 11 B 7

ING Y Insulin, Gastrin, C-Peptide and PTH $170 71 A 27 B 21

ISH ISH In Situ Hybridization $732 190 A 6 B 30

ISH2 ISH In Situ Hybridization, HER2 $736 190 A 6 B 30

J J Transfusion Medicine (Comprehensive, Limited) $369 163 A 9 B 15 C 8

J1 J1 Transfusion Medicine (Comprehensive, Limited) $300 163 A 9 B 15 C 8

JAT JAT Transfusion Medicine Automated Testing $561 165 A 26 B 15 C 21

JE1 J Transfusion Medicine - Educational Challenges $198 166 A 9 B 15 C 8

K K Ligands Assay (General) $465 67 A 6 B 20 C 9

KET KET Ketones $208 57 A 4 B 9

KK K Ligands Assay (General) $636 67 A 6 B 20 C 9

KVM KVM Ligands (General) VM $438 67 A 6 B 20 C 9



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LAS LAS Legionella Antigen Detection (Urine) $188 134 A 11 B 7

LCW LCW Limited Chemistry, Waived $186 52 A 2 B 12

LDM LDM TDM Calibration Verification/Linearity VM $250 92 A 18 B 16

LKM GIH Liver - Kidney Microsomal Antibody

(Anti - LKM) $344 155 A 27 B 28

LLM LLM Ligand Assay Calibration Verification/

Linearity VM $250 92 A 1 B 23

LM LM Lung Maturity $254 61 A 2 B 28

LM1 LM Lung Maturity $298 61 A 2 B 28

LMIP LMIP LMIP $820 38 A 5 B 1 C 1 D 30

LN1 LN1 Chemistry Calibration Verification/Linearity $634 91 A 15 B 7

LN1ER LN1ER Chemistry Calibration Verification/

Linearity Extended Range $730 91 A 15 B 7

LN2 LN2 Chemistry/Lipid/Enzyme Calibration

Verification/Linearity $780 91 A 15 B 7

LN2ER LN2ER Chemistry/Lipid/Enzyme Calibration

Verification/Linearity Extended Range $862 91 A 15 B 7

LN2ERVM LN2ERVM Chemistry/Lipid/Enzyme Calibration

Verification/Linearity Extended Range VM $650 91 A 15 B 7

LN3 LN3 TDM Calibration Verification/Linearity $334 92 A 18 B 16

LN5 LN5 Ligand Assay Calibration Verification/Linearity $318 92 A 1 B 23

LN6 LN6 Urine Chemistry Calibration Verification/

Linearity $378 93 A 18 B 16

LN7 LN7 Immunology Calibration Verification/Linearity $398 93 A 13 B 12

LN8 LN8 Reproductive Endocrinology Calibration


LN9 LN9 Hematology Calibration Verification/Linearity $614 94 A 6 B 28

LN9ER LN9ER Hematology Calibration Verification/Linearity $642 94 A 6 B 28

LN11 LN11 Serum Ethanol Calibration Verification/Linearity $356 95 A 26 B 3

LN11ER LN11ER Serum Ethanol Calibration Verification/Linearity $368 95 A 26 B 3

LN12 LN12 C-Reactive Protein Calibration Verification/


LN13 LN13 Blood Gas/Critical Care Calibration Verification/




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LN13C LN13 Blood Gas/Critical Care Calibration Verification/


LN14 LN14 Whole Blood Ethanol Calibration Verification/


LN15 LN15 Glycohemoglobin Calibration Verification/


LN16 LN16 Homocysteine Calibration Verification/Linearity $564 97 A 9 B 14

LN17 LN17 Whole Blood Glucose Calibration/Verification


LN18 LN18 Reticulocyte Calibration Verification/Linearity $434 98 A 9 B 5

LN19 LN19 Reticulocyte Calibration Verification/Linearity $434 98 A 9 B 5

LN20 LN20 Urine Albumin Calibration Verification/Linearity $330 98 A 13 B 12

LN21 LN21 High Sensitivity C-reactive Protein Calibration


LN22 LN22 Flow Cytometry Calibration Verification/


LN23 LN23 Prostate-Specific Antigen Calibration


LN24 LN24 Creatinine Accuracy Calibration Verification/

Linearity $400 99 A 18-19 B 23-24

LN25 LN25 Troponin I Calibration Verification/Linearity $676 100 A 24 B 22

LN27 LN27 Troponin T Calibration Verification/Linearity $676 100 A 23 B 21

LN30 LN30 B-type Natriuretic Peptides Calibration


LN31 LN31 Immunosuppressive Drugs Calibration


LN32 LN32 Ammonia Calibration Verification/Linearity $380 101 A 26 B 16

LN33 LN33 Serum Myoglobin Calibration Verification/

Linearity $490 102 A 18 B 16

LN34 LN34 CA-125 Calibration Verification/Linearity $552 102 A 20 B 19

LPE ELP Lipoprotein and Protein Electrophoresis $180 56 A 27 B 10

LPX LPX Laboratory Preparedness Exercise $300 136 A 18 B 12

LUM LUM Urine Chemistry Calibration Verification/

Linearity VM $298 93 A 18 B 16



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M M Cerebrospinal Fluid Chemistry $398 62 A 13 B 8

ME ME Monitoring Engraftment $543 182 A 24 B 28 C 11

MGL1 MGL ACMG/CAP Molecular Genetics $998 188 A 23 B 12

MGL2 MGL ACMG/CAP Molecular Genetics $1,230 188 A 23 B 12



MGL5 MGL ACMG/CAP Molecular Genetics $582 188 A 23 B 12

MK MK Immunohistochemistry $594 197 A 16 B 17

ML ML HLA Molecular Typing $666 179 A 17 B 7 C 29

MO MO Molecular Oncology $750 189 A 10 B 8

MO2 MO Molecular Oncology $934 189 A 10 B 8

MO3 MO Molecular Oncology $750 189 A 10 B 8

MPA CSM Mycophenolic Acid $548 50 A 16 B 23

MRD MRD Minimal Residual Disease $738 191 A 21 B 6

MRS MRS Methicillin Resistant S. aureus $196 133 A 2 B 5

MRS5 MRS5 Methicillin Resistant S. aureus, 5 Challenges $300 133 A 2 B 1 C 5

MSI MSI Microsatellite Instability $340 191 A 15 B 19

MVM MVM Cerebrospinal Fluid VM $318 62 A 13 B 8

MX1B MX1 HLA Crossmatching, Antibody Screen, and

Antibody Identification, Class I $642 180 A 27 B 19 C 13

MX1C MX1 HLA Crossmatching, Antibody Screen, and


MX1E MX1 HLA Crossmatching, Antibody Screen, and


MX2B MX2 HLA Crossmatching, Antibody Screen, and

Antibody Identification, Class II $645 181 A 31 B 28 C 3

MX2C MX2 HLA Crossmatching, Antibody Screen, and


MX2E MX2 HLA Crossmatching, Antibody Screen, and


MXB MX2 HLA Crossmatching, Antibody Screen, and

Antibody Identification, Class II $894 182 A 27 A 31 B 19 B 28 C 13 C 3

MXC MX2 HLA Crossmatching, Antibody Screen, and

Antibody Identification, Class I/II $1,452 182 A 27 A 31 B 19 B 28 C 13 C 3



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www.cap.org


MYG MYG Myoglobin, Urine $286 59 A 23 B 20

N N Urine Chemistry (Special) $560 59 A 23 B 6

NAT NAT Nucleic Acid Testing $2,298 175 A 16 B 6 C 19

NB NB Neonatal Bilirubin $204 63 A 6 B 3 C 9

NB2 NB Neonatal Bilirubin, 2 Challenges $154 63 A 6 C 9

NGC NGC Interlab Comparison Prgm in Non-Gynecologic

Cytopath $680 202 A 12 B 13 C 13 D 12

NGC1 NGC Interlab Comparison Prgm in Non-Gynecologic

Cytopath $100 202 A 12 B 13 C 13 D 12

NP NP Neuropathology Program $346 205 A 9 B 10

NP1 NP Neuropathology Program $54 205 A 9 B 10

NVM NVM Urine Chemistry (Special) VM $448 59 A 23 B 6

O OQ Critical Care Aqueous and Fluorocarbon

Blood Gas $411 73 A 2 B 8 C 12

OCB CM Occult Blood $130 118 A 16 B 3

P P Parasitology $348 140 A 19 B 4 C 21

P3 P Parasitology $348 140 A 19 B 4 C 21



PAPE PAP PAP Educational Series 1 for PAP PT and

Non-CLIA Laboratories $432 201 A 2-23 B 3-24

PAPE PAP PAP Educational Series 2 for PAP PT and

Non-CLIA Laboratories $432 201 A 4-25 B 2-23

PAPPT PAP PAP PT Events $$ 200 19 2, 16 9, 23 6, 20 4, 18 1,15,29 13, 27 10, 24 8, 21 5, 19 2, 16 7

PAR PAR AABB/CAP Parentage/Relationship Testing $1,053 176 A 17 B 23 C 22

PARF PARF AABB/CAP Parentage/Relationship Testing $972 176 A 17 B 23 C 22

PCARM PCARM Plasma Cardiac Markers $246 53 A 2 B 8 C 12

PF PF Platelet Function $252 127 A 9 B 12

PF1 PF Platelet Function $236 127 A 9 B 12

PGX PGX Pharmacogenetics $952 187 A 20 B 14

PHG PHG Plasma Hemoglobin $252 65 A 30 B 14

PIP PIP Performance Improvement Program in

Surgical Pathology $612 193 A 16 B 8 C 14 D 7


$$ Call a Customer Contact Center representative for pricing.


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PIP1 PIP Performance Improvement Program in

Surgical Pathology $100 193 A 16 B 8 C 14 D 7

PLA PLA Quantitation of Lp-PLA2 $428 53 A 30 B 28

PM1 PM1 CD117 Immunohistochemistry,

Tissue Microarray $480 199 A 30

PM2 PM2 ER, PR Immunohistochemistry,

Tissue Microarray $480 199 A 18 B 2

PM3 PM3 CD20 Immunohistochemistry, Tissue Microarray $480 199 A 31

PM4 PM4 EGFR Immunohistochemistry, Tissue Microarray $480 199 A 9

PNH PNH Flow Cytometry - Immunophenotypic

Characterization of Paroxysmal Nocturnal

Hemoglobinuria $472 160 A 28 B 27

PNHW PNH Flow Cytometry - Immunophenotypic

Characterization of Paroxysmal Nocturnal

Hemoglobinuria $518 160 A 28 B 27

PS PS Platelet Serology $490 168 A 16 B 19

Q OQ Critical Care Aqueous and Fluorocarbon

Blood Gas $555 73 A 2 B 8 C 12

QF QF M. tuberculosis Infection $330 161 A 18 B 19

Q-PROBES QPR Quality Management Tools $395 34 B 23 C 22 D 21 A 8

Q-TRACKS QTR Quality Management Tools $940 27 B 2 C 8 D 8 A 8

R R Trace Metals $322 63 A 5 B 26

RAP Y Renin, Aldosterone $200 71 A 27 B 21

RDS RDS Rheumatic Disease Special Serologies $328 156 A 18 B 2

RF S Immunology $150 151 A 23 B 17 C 30

RFX S Immunology $240 151 A 23 B 17 C 30

RHIV RHIV Anti-HIV-1 $381 174 A 30 B 10 C 30

RHIVW RHIVW Anti-HIV-1, Waived $150 174 A 30 B 10

ROM ROM Rupture of Fetal Membrane Testing $298 113 A 11 B 14

RRS RRS Reference Range Service $274 102 A 2 B 11

RRS2 RRS2 Reference Range Service $324 102 A 2 B 11



RT RT Reticulocyte $276 110 A 26 B 14



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RT2 RT2 Reticulocyte $276 110 A 26 B 14



RUB S Immunology $150 151 A 23 B 17 C 30

RUBX S Immunology $240 151 A 23 B 17 C 30

RUR RUR Rapid Urease $110 135 A 27 B 10

S2 S2 Immunology (Special), Immunology (Special,

Limited), H. pylori IgG Antibody $474 153 A 6 B 10 C 14

S4 S2 Immunology (Special), Immunology

(Special, Limited), H. pylori IgG Antibody $318 153 A 6 B 10 C 14

S5 S2 H. pylori IgG Antibody $150 153 A 6 B 10

SARC SARC Sarcoma Translocation $380 191 A 12 B 3

SC SEM Semen Analysis $250 121 A 20 B 26

SC1 SEM Semen Analysis $300 121 A 20 B 26

SCM1 SCM Special Clinical Microscopy $182 118 A 16 B 9

SCM2 SCM Special Clinical Microscopy $182 118 A 16 B 9

SCO SCO Serum Carry Over $361 105 A 11

SCP SCP Stem Cell Processing $1,428 169 A* B*SCS SCS Sickle Cell Screening $226 112 A 2 B 10

SDS SDS Serum Drug Screening $278 81 A 23 B 2

SE SE Diagnostic Allergy $549 158 A 30 B 10 C 30

SM SEM Semen Analysis $234 121 A 20 B 26

SM1CD SPCD Sperm Motility and Morphology $234 121 A 20 B 26

SMCD SPCD Sperm Motility and Morphology $336 121 A 20 B 26

SO SO Blood Oximetry $393 74 A 2 B 22 C 26

SP SP Stool Pathogens $326 136 A 18 B 2

SP1 SP Norovirus $300 136 A 18 B 2

SPE ELP Lipoprotein and Protein Electrophoresis $150 56 A 27 B 10

ST ST Shiga Toxin $312 133 A 16 B 10

SV SEM Semen Analysis $234 121 A 20 B 26

SW1 SW Sweat Analysis Series $290 64 A 19 B 6







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T T Toxicology $663 77 A 2 B 20 C 12

TEG TEG Thromboelastogram $198 127 A 13 B 24

TM TM Tumor Markers $508 68 A 19 B 20

TMCA TMCA Transfusion Medicine Competency Assessment -

Comprehensive Transfusion Medicine $396 166 A 26 B 15 C 8

TMCAD TMCAD Transfusion Medicine Competency Assessment -

Direct Antiglobulin Test $200 167 A 2 B 12

TMCAF TMCAF Transfusion Medicine Competency Assessment -

Fetal Red Cell Quantitation $324 168 A 27 B 2

TMX TM Tumor Markers $590 68 A 19 B 20

TRC TRC Transfusion-Related Cell Count $516 170 A 5 B 11 C 24

TRP CAR Cardiac Markers $234 54 A 3 B 2 C 6

TTD TTD Tick-Transmitted Disease $538 145 A 9 B 14

U U Urine Chemistry (General) $298 58 A 5 B 18

UAA UAA Automated Urinalysis $232 116 A 16 B 27

UAA1 UAA1 Automated Urinalysis $232 116 A 16 B 27

UBJP ELP Urine Bence Jones Proteins $250 56 A 27 B 10

UDC UDC AACC/CAP Forensic Urine Drug Testing

(Confirmatory) $1,192 80 A 5 B 27 C 27 D 2

UDS UDS AACC/CAP Urine Drug Testing (Screening) $387 79 A 9 B 15 C 5

UDS6 UDS6 AACC/CAP Urine Drug Testing (Screening),

Limited $270 79 A 9 B 5

UDSM UDSM Urine Drug Testing (Screening) VM $309 79 A 9 B 15 C 5

UMC UMC Urine Albumin/Creatinine $200 116 A 18 B 21

URC CRS Urine Crystals $298 117 A 8 B 12

UT UT Urine Toxicology $549 75 A 2 B 20 C 12

UTCO UTCO Urine Toxicology Carry Over $311 105 A 11

UVM UVM Urine Chemistry (General) VM $240 58 A 5 B 18

V V Viscosity $228 56 A 6 B 5

VBP VBP Online Virtual Biopsies Program $312 194 A 23 B 26 C 24 D 2

VBP1 VBP Online Virtual Biopsies Program $60 194 A 23 B 26 C 24 D 2

VLS VLS Viral Load $552 148 A 22 B 30

VM1 VM AABB/CAP Viral Markers - Series 1 $351 172 A 5 B 11 C 24




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www.cap.org


VM3 VM AABB/CAP Viral Markers - Series 3 $434 173 A 5 B 11

VM4 VM AABB/CAP Viral Markers - Series 4 $744 173 A 5 B 11


VMC VMC Viral Marker Chemistry $225 169 A 2 B 1 C 5

VR1 VR1 Virology Culture $672 143 A 26 B 18 C 21

VR2 VR2 Virology Antigen Detection (DFA) $495 143 A 16 B 13 C 2

VR3 VR3 Virology Antibody Detection $480 144 A 16 B 2

VR3M VR3 Virology Antibody Detection $214 144 A 16 B 2

VR4 VR4 Virology Antigen Detection $366 144 A 5 B 27 C 9

VS VS Vaginitis Screen Antigen Detection $354 135 A 30 B 27 C 26

VS1 VS Vaginitis Screen Antigen Detection $274 135 A 30 B 27

WB2 WB2 Whole Blood Glucose, Waived $192 65 A 9 B 12

WBDD WBDD Whole Blood D-dimer $248 127 A 26 B 8

WBG WBG Whole Blood Glucose $285 65 A 9 B 15 C 12

WP3 WP3 Whole Blood Prothrombin Time $231 126 A 9 B 4 C 21

WP4 WP4 Whole Blood Coagulation $276 126 A 9 B 4 C 21



WP8 WP8 Whole Blood Prothrombin Time/INR -

CoaguChek, Waived $214 126 A 9 B 21

WP9 WP9 Whole Blood Prothrombin Time -

CoaguChek XS Plus $363 126 A 26 B 18 C 8

Y Y Ligands Assay (Special) $386 69 A 27 B 21

YVM YVM Ligands (Special) VM $334 69 A 27 B 21

YY Y Ligands Assay (Special) $486 69 A 27 B 21

Z Z General Chemistry and Therapeutic Drugs $294 47 A 2 B 1 C 5

ZT ZT Therapeutic Drug Monitoring (TDM) (Special) $504 50 A 16 B 1 C 5

ZZT ZT Therapeutic Drug Monitoring (TDM) (Special) $699 50 A 16 B 1 C 5

CA0050 Competency Assessment, 1–50 users $595 22

CA0250 Competency Assessment, 51–250 users $1,295 22

CA1000 Competency Assessment, 251–1,000 users $1,995 22



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24ORDER FORMS

Ord

erFo

rms

New ProductsPRODUCT PRODUCT CODE PAGE

ANATOMIC PATHOLOGYOnline Digital Slide Program in DPATH, DPATH1 195

Dermatopathology

CHEMISTRYLipoprotein-associated phospholipase (Lp-PLA2) PLA 53Neonatal Bilirubin, 2 challenges NB 63Urine Bence Jones Proteins UBJP 56

COAGULATIONCoagulation Special Testing, Series 5— CGS5 125

Heparin Induced Thrombocytopenia

IMMUNOLOGYTotal Hemolytic Complement CH50 152Flow Cytometry, Interpretation only FL5 160

MICROBIOLOGYStool Pathogens SP 136Rapid Norovirus SP1 136

MOLECULAR MICROBIOLOGYMethicillin Resistant Staphylococcus aureus, MRS5 133

5 challengesNucleic Acid Amplification, Organisms IDO 149Nucleic Acid Amplification, Viruses ID1, ID1T 149Nucleic Acid Amplification, Respiratory ID2 150

TRANSFUSION MEDICINEBacterial Detection in Platelets BDP 171

TRANSFUSION-TRANSMITTED VIRUSESViral Markers Series 5— VM5 174

Anti-HAV, IgM and Anti-HBc, IgM

QUALITY MANAGEMENT TOOLSUtilization of STAT Test Priority QP091 35Monitoring of Outpatient Orders

Requiring Clarification QP092 36Quality of Transfusion Documentation QP093 37Mislabeling Rate of Specimens, Blocks,

and Slides in Surgical Pathology QP094 37

2009 Surveys & Anatomic Pathology Education Programs

Documents

Transcript of 2009 Surveys & Anatomic Pathology Education Programs