1 Advanced methods of identification of organic compounds ...

1

Advanced methods of identification of organic compounds ...................................................... 3

Analytical Methods in Drug Design and Technology ................................................................ 7

Biocatalysis in organic synthesis .............................................................................................. 12

Catalytical applications of coordination compounds in organic synthesis .............................. 15

Chemistry and application of metals ........................................................................................ 20

Chemistry and ecology ............................................................................................................. 25

Chemistry and technology of f-electron elements .................................................................... 28

Chemistry and Technology of Nuclear Materials .................................................................... 31

Combinatorial chemistry .......................................................................................................... 36

Crystallography ........................................................................................................................ 40

Electrochemistry ....................................................................................................................... 46

Electrometallurgy ..................................................................................................................... 50

Graduate laboratory I ............................................................................................................... 54

Graduate laboratory II .............................................................................................................. 57

Graduation seminar and thesis preparation .............................................................................. 60

Hydrogen storage and combustion of fuels .............................................................................. 63

Hydrometallurgy ...................................................................................................................... 67

Inorganic drugs ......................................................................................................................... 72

Instrumental Analysis ............................................................................................................... 76

Instrumental drug analysis ....................................................................................................... 81

Introduction to the practice of statistics ................................................................................... 85

Medicinal Natural Products ...................................................................................................... 90

Metal matrix composites and powder metallurgy .................................................................... 96

Metallurgy of non-ferrous metals ............................................................................................. 99

Metals and Environment ........................................................................................................ 102

Mineral processing ................................................................................................................. 106

Modern tendencies in management ........................................................................................ 110

Molecular modeling ............................................................................................................... 114

Multistep Organic Synthesis .................................................................................................. 119

Organic synthesis design: strategies and tactics ..................................................................... 122

Phase Equilibria ...................................................................................................................... 126

Philosophy of science and technology ................................................................................... 130

Physical organic chemistry ..................................................................................................... 134

Principles of Physiological Chemistry ................................................................................... 138

Polymers in medicine ............................................................................................................. 141

Pyrometallurgy ....................................................................................................................... 147

Rational drug design ............................................................................................................... 152

2

Retrieval of scientific and technical information ................................................................... 156

Selected reactions in organic chemistry ................................................................................. 160

Speciation and fractionation analysis of elements in the environment .................................. 164

Spectroscopy .......................................................................................................................... 168

Synthetic Organic Drugs ........................................................................................................ 173

Techniques of organic syntheses – basic operations .............................................................. 178

Techniques of solid supported reactions and combinatorial synthesis .................................. 183

Theoretical Chemistry ............................................................................................................ 186

Thermal analysis and calorimetry .......................................................................................... 199

Waste materials in metallurgy ................................................................................................ 203

3

Zał. nr 4 do ZW 64/2012

Wrocław University of Technology

FACULTY OF CHEMISTRY

SUBJECT CARD

Name in Polish Zaawansowane metody identyfikacji związków

organicznych

Name in English Advanced methods of identification of

organic compounds Main field of study (if applicable) Chemistry

Specialization (if applicable) Organic and Polymer Chemistry

Level and form of studies: 2nd level, full-time

Kind of subject obligatory

Subject code CHC024048

Group of courses NO *delete as applicable

Lecture Classes Laboratory Project Seminar

Number of hours of

organized classes in

University (ZZU) 15 30

Number of hours of total

student workload (CNPS) 30 60

Form of crediting Examination Crediting

with grade

For group of courses mark

(X) final course

Number of ECTS points 2 2 including number of ECTS

points for practical (P) classes 1

including number of ECTS

points for direct teacher-

student contact (BK) classes 1 1

*delete as applicable

PREREQUISITES RELATING TO KNOWLEDGE, SKILLS AND OTHER

COMPETENCES

1. Knowledge of mathematics on university level

2. Knowledge of general chemistry on university level

3. Knowledge of organic chemistry on university 1st level

SUBJECT OBJECTIVES

C1 Recognition of basic and advanced terminology of spectroscopy by students

C2 Recognition of theory of chemical bonds

C3 Obtaining of advanced knowledge of NMR, MS and FTIR spectroscopy

C4 Teaching of interpretation and identification of spectroscopic spectra (NMR, MS,

IR) of organic compounds.

4

SUBJECT EDUCATIONAL EFFECTS

Relating to knowledge:

PEK_W01 – Theoretical and practical bases of application for determination of structures of

organic compounds

PEK_W02 – Properly classification and interpretation of basic spectroscopic spectra of

organic compounds

PEK_W03 – Possession of advanced knowledge of FTIR spectra

PEK_W04 – Possession of advanced knowledge of FTMS spectra

PEK_W05 – Possession of advanced knowledge of NMR spectra

PEK_W06 – Skillful analysis of basic MS, NMR and IR spectra of organic compounds

PEK_W07 – Skillful determination of structure of organic compound on the basis of

spectroscopic spectra.

Relating to skills:

PEK_U01 – Ability to interpretation of basic spectroscopy spectra of organic compounds

PEK_U02 – Ability to determine the structure of compound and connect data from spectra

to the structure of organic compound.

PEK_U03 – Ability to perform basic calculations on the scope of spectroscopy methods

PROGRAMME CONTENT

Form of classes - lecture Number of hours

Lec 1 Introduction to spectrometry of organic compounds. Physical bases

of nuclear magnetic resonance. 2

Lec 2 Spectroscopy of proton nuclear magnetic resonance (1H NMR).

Chemical shift. Simple spin coupling. Overhauser effect. Coupling of

protons to other nuclei.

2

Lec 3 Spectroscopy of 13

C NMR. Registration of 13

C NMR. Chemical

shifts. Decoupling of 13

C-1H spins.

13C NMR. DEPT methods.

2

Lec 4 Spectroscopy of 31

P NMR. Registration of 31

P NMR. Chemical

shifts. NMR of nuclei: 19

F, 15

N, 14

N. 2

Lec 5 Correlation NMR spectrometry. Spectra 1H-

1H COSY. Spectra

1H-

13C COSY.

2

Lec 6 IR spectroscopy. FTIR technics. Application of UV-Vis

spectroscopy. Identification of compounds, analysis of spectra. 2

Lec 7 Mass spectrometry MS.Apparatus, method of ionization. Mass

spectra EI, CI selected organic compounds. Determination of

molecular mass of compounds.

2

Lec 8 Fragmentation. Interpretation of mass spectrum and application to

identification of compounds. 1

Total hours 15

Form of classes - class Number of hours

Cl 1 Interpretation and analysis of the proton nuclear magnetic resonance (1H

NMR) spectra. 2

5

Cl 2 Interpretation and analysis of the proton nuclear magnetic resonance (1H

NMR) spectra. 2

Cl 3 Interpretation and analysis of the carbon nuclear magnetic resonance (13

C

NMR) spectra. Cont. 2

Cl 4 DEPT methods in interpretation of the 13

CNMR spectra 2

Cl 5 Application of the 1HNMR and

13CNMR/DEPT spectra in structure

analysis. 2

Cl 6 Test I 2

Cl 7 Two dimensional spectroscopy (2D NMR). 1H-

1H and

1H-

13C

correlation (COSY and HMQC spectra). 2

Cl 8 Two dimensional spectroscopy (2D NMR). Other two dimensional

techniques (INADEQUATE, TOCSY, HMBC and ROESY spectra). 2

Cl 9 Application of the two dimensional spectroscopy in structure

analysis. 2

Cl 10 Spectroscopy of other nuclei with spin ½. (31

P NMR, 15

N MMR, 19

F

NMR spectroscopy) 2

Cl 11 Application of the IR spectroscopy in structure analysis. 2

Cl 12 Application of the mass spectrometry in structure analysis. 2

Cl 13 Application of the 1D,2D NMR, IR and MS techniques in structure

analysis. 2

Cl 14 Test II 2

Cl 15 Correction of the I or II test 2

Total hours 30

TEACHING TOOLS USED

N1 Lecture with multi medial presentation.

N2 Solution of problems and interpretation of spectroscopy spectra.

N3 Interactive system of electronic lessons.

EVALUATION OF SUBJECT EDUCATIONAL EFFECTS ACHIEVEMENT

Evaluation

F – forming (during

semester),

C – concluding (at

semester end)

Educational effect

number Way of evaluating educational effect

achievement

F1 (lecture) PEK_W01-

PEK_W07

Examination

F2 (classes) PEK_U01 First test

F3 (classes) PEK_U01-

PEK_U03

Final test

C – final examination

6

PRIMARY AND SECONDARY LITERATURE

PRIMARY LITERATURE:

[1] R. M. Silverstein, F. X. Webster, D. J. Kiemle “Spektroskopowe Metody Identyfikacji

Związków Organicznych” PWN, Warszawa 2007

SECONDARY LITERATURE:

[1] Praca zbiorowa: R. Mazurkiewicz, A. Rajca, E. Kalwińska, A. Skibiński, J. Suwiński,

W. Zieliński „ Metody Spektroskopowe i ich zastosowanie do identyfikacji związków

organicznych” W N-T, Warszawa 1995

SUBJECT SUPERVISOR

(NAME AND SURNAME, E-MAIL ADDRESS)

Prof. Dr hab. eng. Bogdan Boduszek, [email protected]

MATRIX OF CORRELATION BETWEEN EDUCATIONAL EFFECTS

FOR SUBJECT

AND EDUCATIONAL EFFECTS FOR MAIN FIELD OF STUDY

Subject

educational

effect

Correlation between subject

educational effect and educational

effects defined for main field of study

and specialization (if applicable)**

Subject

objectives*** Programme

content*** Teaching tool

number***

(knowledge)

PEK_W01 K2Ach_W03 C1 Lec 1 N1

PEK_W02 K2Ach_W03 C1 Lec2-Lec3 N1

PEK_W03 K2Ach_W03 C1, C2

Lec 2,

K2Ach_W03Le

c3

N1


PEK_W05 K2Ach_W03 C3 Lec 5 N1, N3

PEK_W06 K2Ach_W03 C3, C4 Lec 6 N1, N3

PEK_W07 K2Ach_W03, K2Ach_W04 C4 Lec 6, Lec 7 N1, N3

(skills)

PEK_U01 K2Ach_W03

Cl1-Cl4, Cl7-8,

Cl10 N2

PEK_U02 K2Ach_W03 Cl5-Cl6,

Cl9, Cl11-Cl15 N2

PEK_U03 K2Ach_W03, K2Ach_W04 Cl1-Cl2,

Cl6, Cl12

N2

K2Ach_W03

** - enter symbols for main-field-of-study/specialization educational effects

*** - from table above

7

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish Zastosowanie Metod Analitycznych w

Projektowaniu i Technologii Wytwarzania Leków

Name in English Analytical Methods in Drug Design and

Technology Main field of study (if applicable) Chemistry

Specialization (if applicable) Medicinal Chemistry




Group of courses YES *delete as applicable


Number of hours of




student workload (CNPS)

Form of crediting Crediting

with grade Crediting

with grade


(X) final course








COMPETENCES

4. Principles of organic chemistry, theoretical and practical.

5. Basic knowledge on chromatographic and spectroscopic methods.

6. Knowledge in the field of basis of analytical chemistry is recommended.

SUBJECT OBJECTIVES

C1 Application of Good Laboratory Practice and validation procedures in analytical

methods.

C2 Gaining of the knowledge on the modern chromatographic techniques and their

applications in drug design and technological process of drugs production.

C3 Acquaintance with the different technological concepts of application of

spectroscopic methods in drugs design and quality control in the production system.

C4 Expanding the knowledge in the field of electrochemical methods applications in the

design of biologically active compounds and the production procedures of them.

C5 Acquaintance with the different concepts in the field of mixed analytical methods

8

useful in drugs design and quality control.



Student, who has completed the course:

PEK_W01 – has knowledge on the Good Laboratory Practice rules and validation

procedures necessary to be used in analytical methods,

PEK_W02 – has knowledge on the modern chromatographic, spectroscopic, electrochemical

and mixed analytical techniques and their applications in drug design and

technological process of drugs production,

PEK_W03 – can define the advantages and disadvantages of the analytical techniques, the

sensitivity level of each of them.

Relating to skills:


PEK_U01 – has skills of use liquid chromatography technique and thin layer

chromatography method for separation of a mixture of different compounds, to

detect them, do interpretation of the results and prepare the report according to

GLP,

PEK_U02 – has knowledge how to use HPLC system, how to prepare the sample, and how

to do the analysis of a mixture of compounds, how to do qualitative and

quantitative analysis of them, do interpretation of the results and prepare the

report according to GLP,

PEK_U03 – has knowledge about using different types of mass spectrometry instruments,

and about the parameters of the sample ready to analyze,

PEK_U04 – has skills to do the analysis of a mixture compounds using gas chromatography

system, to do interpretation of the results and to prepare the report according to

GLP,

PEK_U05 – has skills to do the analysis of the biologically active compounds using

electrochemical methods, do interpretation of the results and prepare the report

according to GLP,

PEK_U06 – has skills to detect the biologically active compounds in a drug formulation

using UV-Vis methodology, to prepare a sample, also to control their synthesis

following by the kinetic parameters of the reaction,

PEK_U07 – has knowledge how to estimate the rheological parameters of the drug

formulation using viscosimetric technique, to prepare the sample,

PEK_U08 – has skills to use multiplates reader for turbidimetric measurements, do

interpretation of the results and prepare the report according to GLP.

PROGRAMME CONTENT


Lec 1 Introduction to analytical techniques as tools for drug design and

production. Good Laboratory Practice rules in analytical chemistry.

Pharmacopoeias. Drugs production normalization rules.

2

Lec 2 Error estimation in analytical methods used in drugs design and

technology. Validation techniques. 2

9

Lec 3 Chromatographic techniques in drugs design and control of

production process. 2

Lec 4 Mixed advanced analytical techniques as a tool in drugs design and

control of their activity. 2

Lec 5 Immunoenzymatic assays in design and technology of drugs. 1

Lec 6 Mass spectrometry - principles of the method, types of ionization,

comparison of used types of analyzers. Principles of fragmentation,

application of the method in the investigation of macromolecules

structure.

2

Lec 7 Potentiometry and conductometry as modern analytical methods. 2

Lec 8 Voltamperometry and other electrochemical methods in drug design

and technology. 2

Total hours 15

Form of classes - laboratory Number of hours

Lab 1 Safety rules in the laboratory of organic chemistry, good laboratory

practice and the rules of the reports preparation. 4

Lab 2 Liquid chromatography – the separation technique useful in

pigments separation. TLC method as a tool of quality control

procedure.

4

Lab 3 HPLC technique – a scheme of the procedure of a sample

preparation. Gripex – isolation of three biologically active

compounds – preparation of a sample to HPLC analysis.

4

Lab 4 HPLC – the equipment scheme. The analysis of Gripex biologically

active components. 4

Lab 5 Scheme of mass spectrometer, types of ionization sources and

analyzers. Training in principles of fragmentation. 4

Lab 6 Possible applications of MS in medicine and pharmacy. Application

of ESI in searching of impurities in drugs. 4

Lab 7 GC equipment and the procedure of analysis. Application of MS as

the detection technique. Separation and identification of the

perfume mixture components.

4

Lab 8 Potentiometry – the method used for potentiometric titration of the

biologically active molecules possessing positive or negative

charge. Application of potentiometric titration to pH-metric

analysis.

4

Lab 9 Conductometry – principles of the analytical method based on the

Ohm’s law. The presentation of the application of this technique in

the biologically active compounds design.

4

Lab 10 Voltamperometry – the application of the method to analyze the

compounds with the electric charge. Presentation of the procedure

of analysis and results interpretation.

4

Lab 11 Viscosimetry – presentation of the method and application

possibilities. Preparation of the emulsion and measurement of its

reological parameters.

4

Lab 12 Spectrophotometry UV-Vis – principles of the method and

procedure of measurement. The quality analysis of an emulsion

containing sun protection factors.

4

10

Lab 13 UV-Vis method as the tool to control of kinetic of a reaction.

Control technique of synthesis of the biologically active compound. 4

Lab 14 Turbidimetry – the analytical method useful to drug design and

quality control of it. Control of silver salts formation using

microplates reader.

4

Lab 15 Repeating of the not successful realized experiments. Consultation of the

reports results. 4

Total hours 60

TEACHING TOOLS USED

N1 Lecture with multimedial presentation.

N2 Experiment realizing.

N3 Report preparation.


Evaluation


semester),

P – concluding (at

semester end)

Educational effect


achievement

P1 PEK_W01– W04 Average note of 11 grades of 11 short tests

verifying student’s knowledge.

P2 (laboratory) PEK_U01 – U05 Average note of 10 grades of 10 completed

reports, containing result, calculations and

conclusions, prepared according to good

laboratory practice rules.


PRIMARY LITERATURE:

[2] J. Ermer, J.H.McB. Miller, Method Validation in Pharmaceutical Analysis. A Guide to

Best Practice. Wiley-VCH, Weincheim. 2005.

[3] Farmakopea Polska V, Urząd Rejestracji Leków, Wyrobów Medycznych I Produktów

Biobójczych, Warszawa, 1990.

[4] W. Jennings, E. Mittlefehldt, P. Stremple, Analytical Gas Chromatography. 2nd

Ed.

Academic Press, 1997.

[5] R.P.W. Scott, Tandem Techniques. John Wiley & Sons, 1997.

[6] M.S. Lee, Integrated Strategies in Drug Discovery Using Mass Spectrometry. John

Wiley & Sons, 2005.

[7] A.J. Bard, R.L. Faulkner, Electrochemical Methods. Fundamental and Applications.

John Wiley & Sons, 2001.


11

[1] D.M. Bliesner, Validating Chromatographic Methods. A Practical Guide. John Wiley

& Sons, 2006.

[2] P.A. Christensenand A. Hamnett, Techniques and Mechanisms in Electrochemistry.

Kluver Academic Press, 1994.

[3] AC Moffat, MD Osselton, B Widdop, Clarke's analysis of drugs and poisons.

Pharmaceutical Press, 2005.

[4] F.A. Settle, Handbook of Instrumental Techniques for Analytical Chemistry. Prentice-

Hall Inc., 1997.

SUBJECT SUPERVISOR


Izabela Pawlaczyk, [email protected]


FOR SUBJECT

Analytical Methods in Drug Design and Technology


Medicinal Chemistry

Subject

educational

effect





Subject



number***

PEK_W01 S2Ach4_W08 C1 Lec1 Lec8 N1

PEK_W02 S2Ach4_W08 C1, C2, C3, C4,

C5 Lec3 – Lec8 N1

PEK_W03 S2Ach4_W08 C1, C2, C3, C4,

C5 Lec2 – Lec8 N1

PEK_U01 S2Ach4_U07 C1, C2 Lab1, Lab2,

Lab15 N2, N3

PEK_U02 S2Ach4_U07 C1, C2, C3, C5 Lab1, Lab3,

Lab4, Lab15 N2, N3

PEK_U03 S2Ach4_U07 C1, C3

Lab1, Lab5,

Lab6, Lab7,

Lab15

N1, N2, N3

PEK_U04 S2Ach4_U07 C1, C2, C3, C5 Lab1, Lab5,

Lab7, Lab15 N2, N3

PEK_U05 S2Ach4_U07 C1, C4

Lab1, Lab8,

Lab9, Lab10,

Lab15

N2, N3


Lab13, Lab15 N2, N3


Lab15 N2, N3

PEK_U08 S2Ach4_U07 C1, C3, C5 Lab1, Lab12,

Lab14, Lab15 N2, N3



12

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish Biokatalizatory w syntezie organicznej

Name in English Biocatalysis in organic synthesis Main field of study (if applicable) Chemistry

Specialization (if applicable) Organic and polymer chemistry






Number of hours of


University (ZZU)

15


student workload (CNPS) 30

Form of crediting essay

Examination

/ crediting

with grade*

Examination

/ crediting

with grade*

Examination

/ crediting

with grade*

Examination

/ crediting

with grade*


(X) final course

Number of ECTS points 1 including number of ECTS

points for practical (P) classes



student contact (BK) classes 0,5



COMPETENCES

7. Knowledge of the basic organic chemistry

SUBJECT OBJECTIVES

C1 Presentation of possible applications of biocatalysis in organic synthesis

C2 Guiding how to choose proper biocatalyst

C3 Acknowledging adventeges and limitations of application of chemoenzymatic

reactions in multistep synthesis

13



After the course student:

PEK_W01 – understands how to design chemoenzymatic reactions

PEK_W02 – acknowledge advantages and limitations of biocatalysis

PEK_W03 – understands ecologic and economic consequences of application of biocatalysis

in organic chemistry

PEK_W04 – is able to manage process of chemoenzymatic preparation of certain compound

PROGRAMME CONTENT


Lec 1

Lec 2

Introduction. Biocatalysis as an element of Green Chemistry and

axiom of Sustainable Development. Biotransformation versus

biodegradation, types of xenobiotics transformations and their

importance for biocatalytic processes.

2

Lec 3

Lec 4

Applications of biotransformations. Methods and goals of

biocatalyst selection for chemoenzymatic processes (retrosynthesis).

Biocatalysis with the use of whole cells versus enzymes.

2

Lec5

Lec6

Application of biotransformations. Advantages and limitations of

catalytic biotransformations. The choice of biocatalyst. 2

Lec7

Lec8

Application of biotransformations. (i) synthesis of useful building

blocks; (ii) biocatalysis as a mean of selective modifications of

complex organic molecules; (iii) extraordinary chemical reactions

catalyzed by microorganisms; (iv) biotransfromations as a source of

chiral compounds; (v) preparation of biodegradable polymers,

including the use of renewable substrates.

2

Lec9

Lec10

Review of most popular biocatalysts. Red-ox reactions as the

method for the preparation of useful synthons. Lipases and lipolytic

microorganisms as the most popular biocatalysts. Biocatalytic

hydrolysis of nitriles, amides and amino acids derivatives as an

element of technological platforms for drug production.

2

Lec11

Lec12

Solvent and substrate engineering. Dependence of the course of

biocatalysis on substrate structure. Domino reactions. Reactions in

organic solvents. Application of ionic liquids and supercritical gases.

2

Lec13

Lec14

Immobilization of enzymes and microorganisms. Methods and

types of immobilization. Application of nanoparticles. 2

Lec15 Discussion of prepares essays

Total hours

14

TEACHING TOOLS USED

N1 Monographic lecture with multimedia presentation


Evaluation


semester),


semester end)

Educational effect

number

Way of evaluating educational effect

achievement

P (lecture) PEK_W01 –

PEK_W15

essay – presentation of chosen

chemoenzymatic process


PRIMARY LITERATURE:

[1] P. Drauz & H. Waldmann Eds, Enzyme Catalysis in Organic Synthesis, Weinheim 2002

[2] K. Faber, Biotransformations in Organic Chemistry, Springer Verlag, 2011


[1] H. Griengl, Biocatalysis, Springer-Verlag, 2000

[2] K. Drauz, H. Groeger, O. May, enzyme Catalysis In Organic Synthesis, Wiley VCH Verlag, 2012

[3] Multistep Enzyme Catalysis: Biotransformations and Chemoenzymatic Synthesis , ed. E. Garcia-

Junceda, wiley VCH Verlag, 2008

SUBJECT SUPERVISOR


Prof.dr hab. inż. Piaweł Kafarski, [email protected]


FOR SUBJECT

Biocatalysis in organic synthesis


Chemistry

Subject

educational

effect





Subject

objectives***

Programme

content***

Teaching tool

number***

(knowledge)

PEK_W01 S2Ach3_W08 C1,C2 Lec1-Lec14 N1, N2

PEK_W02 S2Ach3_W03, S2Ach3_W08 C3 Lec3, Lec4 N1, N2


15

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish : Katalityczne zastosowania związków

koordynacyjnych w syntezie organicznej

Name in English:

Catalytical applications of coordination

compounds in organic synthesis Main field of study (if applicable)

Chemistry

Specialization (if applicable) Chemistry of organic compounds and polymers

Level and form of studies: 2nd* level, full-time





Number of hours of


University (ZZU) 30



Form of crediting Examination For group of courses mark

(X) final course





student contact (BK) classes 1



COMPETENCES

8. Organic , inorganic and physical chemistry on the level of the 1-st level

9. Elementary mathematics

SUBJECT OBJECTIVES

C1 Familiarization of students with the basic terminology governing in coordination

chemistry with a particular consideration of Werner, organometallic,

inorganometallic and cluster compounds

C2 To get a fundamental knowledge in the scope of thermodynamics and kinetics of

metal complexes

C3 Get to know various kinds of bonding in coordination compounds

C4 Get to know isomerism of coordinationj compounds

C5 Get to know the most important methods in preparative chemistry including these

exhibiting catalytic properties

16

C6 Learning on application of coordination compounds

C7 Acquaint student with fundamental knowledge of homogenic catalysis

C8 Get to know student with basic reactions creating catalytical cycles

C9 Get to know classical organic reactions using catalytical properties of transition

metal complexes



PEK_W01 – knows fundamental concepts and can name the complex

PEK_W02 – become acquainted with the problems related to stability of metal coordination

compounds

PEK_W03- knows the interactions which determine the strengths of the chemical bonding in

complexes

PEK_W04- become aquainted with the problems of isomerism of coordination compounds

PEK_W05- knows the methods of preparations and analysis of coordination compounds

PEK_W06- knows the role of coordination compounds in biology and medicine

PEK_W07- knows the examples from other fields of complex compound applications

PEK_W08- knows the basic concepts of reaction kinetics and knows how to measure

catalytical properties of complexes

PEK_W09-knows the important chemical reactions using catalytical properties of

organometallic compounds

PEK_W10-knows the main mechanisms of the reactions in organometallic chemistry

PEK_W11- knows the methods of reaction conducting to obtain non-racemical products.

PROGRAMME CONTENT


Lec 1 Basic concepts. Historic outline. Complex definition. Nomenclature.

Coordination number. Examples of complex forms of various

coordination numbers.

2

Lec 2 Thermodynamics and kinetics of complexation.

Fundamental definitions. Stability constant. Equilibria of

complexation processes. Factor influencing the stability of

complexation. Chelate and macrocyclic effects. Hard and Soft Lewis.

acids and bases. The importance of stability constants. Fundamental

concepts of chemical kinetics. Kinetic classification of complexation

reactions. Experimental methods in kinetics.

2

Lec 3 Bonding in metal complexes. Classification. 2

Lec 4 Isomerism in complexes. Classification. Constitutional and

stereoisomerism. Examples.Spin, conformation and supramolecular

isomerism. .

2

Lec 5 Preparation of metal complexes. Complexes in solution and the

solid state. Organometallic, inorganometallic and cluster

compounds. Solvents. Nucleophilic addition and redox reactions.

Insertion and elimination in ligands. More important types of

2

17

chemical reactions in the preparative chemistry. Synthesis of

optically active compounds, Physicochemical methods applied in

synthesis of complex compounds.

Lec 6 Application of metal complexes. Outline. Synthetic oxygen

carriers. Sensors. Fuel cells. Solar batteries. Nanotechnology.

Environmental protection.

2

Lec 7 Applications. Metal complexes in biological systems. Bertrand

curve. Examples of coordination forms in biology. Macromolecules

as a fundamental form of metals in biology. The main functions of

metals in the nature: charge supplying, structure stabilization,

electron carries, transport, catalytical functions. 2

Lec 8 Application of metal complexes. Inorganic drugs. Diagnosis and

therapy. Active metals and ligands. 2

Lec 9 Introduction to catalysis. Kinetics and mechanisms. Basic

concepts in chemical kinetics. Classification of complexation

reactions. Exchange reactions. Classification of reactions according

to Gray-Langford classes, metal ion configuration, symmetry of the

central ion environment.

2

Lec

10 Introduction to catalysis. Kinetics and mechanisms of

complexation. Reactions with solvent. Trans-effect, Redox

reactions. Inner and outersphere mechanisms. Kinetics of

isomerization reactions. Experimental and theoretical methods in

kinetical analysis.

2

Lec

11

Fundamental concepts in catalysis. Recall the key problems

related to kinetics of catalyzed reactions , RDS and activation

methods in organic chemistry. Introduction of the catalytical

turnover (TON, TOF) concepts to the description of catalyst activity

and lifetime.

1

Lec

12

Mechanisms of organometallic reactions. Description of the key

elements in organometallic catalysis: oxidative addition-reductive

elimination, migration addition and beta-elimination, nucleophillic

and electrophilic attack on carbon atoms bound to the central metal,

transmetallic processes. Conditions for mutual ligand orientation and

the proper ligand selection.

3

Lec

13

Classical hydrogenation reactions. Homogenic hydrogenation and

hydroformylation reactions with rhodium and ruthenium complexes

as catalysts. Examples for enantioselective reactions. 1

Lec

14 Classical reactions catalyzed with palladium complexes.

Mechanisms. General principles governing reactivity of the

systems. Application for the following classical reactions with

square planar palladium and copper complexes: Suzuki-Miaura,

Negishi, Stille, Truji-Trost, Heck, Buchwakd-Hartwig, Ullman (Cu),

Sonogashira. Some examples of asymmetrical applications will be

presented.

4

Lec

15

Metathesis reactions. Mechanisms and examples of applications of

methatesie reactions with carbonic ruthenium (Grubbs) and

molybdenum (Schrock)m reactions. 1

Total 30

18

TEACHING TOOLS USED

N1 Lecture with multimedial presentation

N2 Problem (critique ) study

…


Evaluation


semester),


semester end)

Educational effect

numer Way of evaluating educational effect

achievement

F1

F2

…

C (lecture)

PEK_W01-PEK_W11 S2Ach3 Final examination


PRIMARY LITERATURE:

[8] J. Ribas Gispert, Coordination Chemistry, Wiley-VCH, 2008

[9] W. Kaim, B. Schwederski, Bioinorganic Chemistry: inorganic elements in

the chemistry of life. An Introduction and Guide, Wiley (1994)

[10] Hegedus, L. S.; Söderberg, B. C. G.: Transition Metals in the Synthesis of Complex

Organic Molecules, 3rd

Ed. University Science Books, Sausalito CA (2010).

IN POLISH:

[11] A. Bielański, Podstawy chemii nieorganicznej, PWN, Warszawa, 2010

[12] M. Cieślak-Golonka, J. Starosta, M. Wasielewski, Wstęp do chemii koordynacyjnej,

PWN, Warszawa, 2010

[13] A. Bartecki, Chemia pierwiastków przejściowych, OW PWr, Wrocław (1996)

SECONDARY LITERATURE

[2] G.A. Lawrence, Introduction To Coordination Chemistry, Wiley, 2010

[3] R.M. Roat-Malone, Chemia bionieorganiczna, PWN, 2010,

[4] M.J. Kendrick, M.T. May, M.J. Plishka, K.D. Robinson, Metals in Biological

Systems, E.Horwood (1992)

[5] Comprehensive Coordination Chemistry, Elsevier (2004)

[6] Pruchnik, F.: Kataliza homogeniczna, PWN (1993)

19

SUBJECT SUPERVISOR


Maria Cieślak-Golonka, [email protected]


FOR SUBJECT

Catalytical Applications of coordination compounds

in organic synthesis


Chemistry

SuMarbject

educational

effect





Subject



number***

(knowledge)

PEK_W01 S2Ach3_W06 C1 W1 N1,N2

PEK_W02 S2Ach3_W06 C2 W2, W9, W10 N1,N2




PEK_W06 S2Ach3_W06 C6 W7, W8 N1,N2


PEK_W08 S2Ach3_W06 C2 W9, W10 N1,N2

PEK_W09 S2Ach3_W06 C7, C9 W13, W14,

W15 N1,N2

PEK_W10 S2Ach3_W06 C7, C8 W11, W12 N1,N2

PEK_W11 S2Ach3_W06 C6, C7, C9 W13, W14,

W15 N1,N2

…



20

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish: Chemia i zastosowanie metali

Name in English: Chemistry and application of metals Main field of study (if applicable): Chemistry

Specialization (if applicable) Chemical Metallurgy

Level and form of studies: 2nd

level, full-time





Number of hours of





Form of crediting Examination crediting

with grade


(X) final course





student contact (BK) classes 0.5 2



COMPETENCES

10. Knowledge of general chemistry (range of knowledge covering lecture General

Chemistry).

11. Knowledge of the basis of inorganic chemistry (range of knowledge covering lecture

Basis of Inorganic Chemistry).

SUBJECT OBJECTIVES

C1 Reminder and establishment of knowledge concerning the construction of periodic

table and resulting physicochemical properties of elements.

C2 Acquainting students with systematics s- and p-electron metallic elements.

C3 Acquainting of systematics of d- and f-electron elements.

C4 Familiarization of students with basic physicochemical properties of lanthanides and

actinides.

C5 Obtaining of basic knowledge about production and application of metals

C6 Familiarization with division of cations into analytical groups.

C7 Acquainting students with characteristic reactions for identification of cations of

21

particular analytical groups.

C8 Acquainting with methods of separation and identification of cations in mixtures

containing cations of different analytical groups.

C9 Acquainting with methods of qualitative analysis of alloys.

C10 Acquainting with safety rules in chemical laboratory and with practical approach to

laboratory exercises.



PEK_W01 – knows basic concepts and chemical laws,

PEK_W02 – knows periodic table,

PEK_W03 –can correctly specify basic properties of metallic elements on the basis of their

location in periodic table of elements,

PEK_W04 – knows physicochemical properties of metallic elements of particular groups of

periodic table,

PEK_W05 – knows the most important applications of particular metallic elements and

their alloys

PEK_W06 – has basic knowledge about modern metallurgical processes.

Relating to skills:

PEK_U01 – knows how to make division of cations into particular analytical groups,

PEK_U02 – is capable to perform practically and write characteristic reactions of cations of

particular analytical groups,

PEK_U03 – can perform analysis of of cations mixture in the range of particular group,

PEK_U04 – is capable to perform analysis of unknown mixture of cations coming from

different analytical groups,

PEK_U05 – knows how to make identification of main components of unknown alloy,

PEK_U06 – knows how to perform laboratory exercises in accordance with safety rules of

laboratory.

PROGRAMME CONTENT


Lec1

Periodic Table of Elements. Correlation between periodic table of

elements and quantum model of atom. Periods and groups of s-, p-,

d- and f-electron elements. Periodicity of atomic volumes and radii,

energy of ionization and electron affinity. Division of elements into

metals, matalloids and nonmetals. Acidic, amphoteric and basic

properties of elements and their oxides. Anticipation of some

properties of elements on the basis of their location in periodic table.

2

Lec2 General description of metallurgical processes – unit operations of

hydro- and pyrometallurgy 3

Lec2 Alkali metals and alkaline earth metals – general properties,

abundance, minerals, production and application of metals 2

Lec3 Metallic elements of group 13-16 – general properties and 2

22

production, allotropy,, aluminum, oxide and hydroxide of aluminum,

amphoteric properties of aluminum and gallium, indium and

thallium.

Lec4 Selected topics concerning d-electron elements- electronic structure,

degrees of oxidation, abundance, metals production and application 2

Lec5

Lanthanides– general properties, abundance, production and

application, electronic structure and degree of oxidation, lanthanide

contraction, the most important compounds, luminescence, lasers.

2

Lec6 Actinides – general properties, abundance, production and

application. 2

Total hours 15


Lab 1 Organizational exercises. Safety and laboratory rules, principles of

assessment, program of exercises. Demonstration of laboratory glass

and equipment. Practical remarks concerning laboratory work.

4

Lab 2 Characteristic reactions of I group cations: Ag+, Pb

2+, Hg2

2+. 4

Lab 3 Characteristic reactions of II group cations: Ba2+

, Ca2+

, Sr2+

. 4

Lab 4 Analysis I.

Separation and identification of I and II group cations

Small written exam I.

4

Lab5 Characteristic reactions of III group cations: Hg2+

, Cu2+

, Cd2+

, Bi3+

,

As5+

, As3+

, Sb5+

, Sb3+

.

6

Lab6 Analysis II.

Separation and identification of III group cations.

Small written exam II.

4

Lab7 Characteristic reactions of IV group cations: Ni2+

, Co2+

, Fe3+

, Cr3+

,

Mn2+

, Zn2+

, Al3+

.

6

Lab8 Analysis III.

Separation and identification of IV group cations

6

Lab9 Analysis IV.

Separation and identification of mixture of I, III and IV group

cations

Small written exam III.

6

Lab10 Characteristic reactions of V group cations: K+, Na

+, NH

4+, Mg

2+ 2

Lab11 Analysis V.

Qualitative analysis of main components of unknown alloy

Small written exam IV.

8

Lab12 Quantitative analysis of lanthanide halide 2

Lab13 Completing arrears 4

Total hours 60

TEACHING TOOLS USED

N1 Lecture with multimedia presentation.

23

N2 Theoretical introduction.

N3 Executive instructions for laboratory exercises.

N4 Realization of exercises.


Evaluation


semester),


semester end)

Educational effect number Way of evaluating educational effect

achievement

C1 (lecture) PEK_W01 – PEK_W06 Written exam

F1(laboratory) PEK_U01 – PEK_U06 4 small written exams (max. 4 x 50

points.)

Recalculation of points from small written exams into marks:

3.0 if (F1) = 100-120 points

3.5 if (F1) = 121-140 points

4.0 if (F1) = 141-160 points

4.5 if (F1) = 161-180 points

5.0 if (F1) = 181-200 points

F2 (laboratory) PEK_U01 –PEK_U07 5 analyses (max. 5 x 5 points)

Recalculation of points for analysis into marks:

3.0 if (F2) = 4.0-8.0 points

3.5 if (F2) = 8.5-12.5 points

4.0 if (F2) = 13.0-17.0 points

4.5 if (F2) = 17.5-21.5 points

5.0 if (F2) = 22.0-250 points

C2 (laboratory) = 0,5*((F1) +(F2))


PRIMARY LITERATURE:

[1]. C.E. Hauscroft, A.G. Sharpe, Inorganic Chemistry, Pearson

Educational Limited, Harlow (England), 2005.

[2] Chiranjib Kumar Gupta, Chemical Metallurgy: Principles and Practice, 2003 WILEY-

VCH Verlag GmbH & Co. KGaA, Weinheim

[3]. P.A. Cox, Chemia nieorganiczna – krótkie wykłady, Wyd. Naukowe

PWN, Warszawa, 2003.

[4]. F.A. Cotton, G. Wilkinson, P.L. Gaus, Chemia nieorganiczna –

podstawy, Wyd. Naukowe PWN, Warszawa, 1995.

[5]. T. Lipiec,, Z.S. Szmal, „Chemia analityczna z elementami analizy

instrumentalnej”. PZWL, Warszawa 1997 – instructions in English will be prepared for

students

[6]. J. Minczewski, Z. Marczenko, Chemia Analityczna 1. Podstawy teoretyczne i

analiza jakościowa , PWN. - – instructions in English will be prepared for students


24

[1] Fathi Habashi, Principles of extractive metallurgy, vol.2, Hydrometallurgyy, Gordon

and Breach Science Publishers, S.A. 1985

[2] Fathi Habashi, Principles of extractive metallurgy, vol.3,Pyrometallurgy, Gordon and

Breach Science Publishers, S.A. 1985

SUBJECT SUPERVISOR


D Sc. Leszek Rycerz, prof.; [email protected]


FOR SUBJECT

Inorganic Chemistry


Chemistry

Subject

educational

effect





Subject



number***

(knowledge)

PEK_W01 S2Ach5_W01 C1 Lec1 N1


PEK_W03 S2Ach5_W01 C2-C4 Lec2-Lec6 N1


PEK_W05 S2Ach5_W01 C5 Lec2-Lec6 N1

PEK_W06 S2Ach5_W01 C5 Lec2-Lec-6 N1

(skills)

PEK_U01 S2Ach5_U01 C6

Lab1-Lab10

N2-N4

PEK_U02 S2Ach5_U01 C7 Lab2-Lab10 N2-N4


PEK_U04 S2Ach5_U01 C8 Lab2-Lab10 N3, N4

PEK_U05 S2Ach5_U01 C9 Lab11 N3, N4

PEK_U06 S2Ach5_U01 C10 Lab1 N2-N4



25

Zał. nr 4 do ZW 64/2012

Wroclaw University of Technology


SUBJECT CARD

Name in Polish Chemia a ekologia

Name in English Chemistry and ecology

Main field of study Chemistry Specialization - Level and form of studies 2nd level, full-time Kind of subject Optional course


Group of courses No


Number of hours of organized classes in

university (ZZU) 30

Number of hours of total student

workload (CNPS) 60

Form of crediting crediting

with grade

For group of courses mark (X) final

course

Number of ECTS points 2

including number of ECTS points for

practical (P) classes 0

including number of ECTS points for

direct teacher-student contact (BK)

classes

1

PREREQUISITES RELATING TO KNOWLEDGE, SKILLS AND OTHER COMPETENCES:

1. Knowledge of chemistry and physics at the high school level.

SUBJECT OBJECTIVES

C1 Getting basic knowledge of the ecological chemistry.

C2 Gaining basic knowledge of the anthropogenic changes in the atmospheric, water and soil environment.

C3 Getting basic knowledge of the environmental factors and biogeochemical cycles influencing on the

environment.

C4 Obtaining basic knowledge on organic farming, healthy food and GMO.

C5 Gaining basic knowledge on renewable energy in Poland and in the world.


relating to knowledge:

PEK_W01 – has knowledge of the ecological chemistry.

PEK_W02 – has knowledge of the environmental factors and biogeochemical cycles in the environment.

PEK_W03 – recognizes the issues of healthy foods, food additives and its harmfulness.

PEK_W04 – knows the problems of municipal and industrial wastes and methods of their disposal and recycling.

PEK_W05 – knows and understands the problems of global warming and knows how to prevent this

26

phenomenon.

PEK_W06 – have knowledge of the type of renewable energy in Poland and in the world.

PROGRAMME CONTENT

Form of classes - lecture Number

of hours

Lec1

Fundamentals of ecology - the basic concepts and characteristics of issues: the biosphere,

atmosphere, hydrosphere and lithosphere. 2

Lec2 The origin and distribution of chemical elements on Earth and in the Universe. 2

Lec3 Ecological factors - Liebig’s and Shelford’s law. Abiotic and biotic environmental factors. 2

Lec4 The main biogeochemical cycles in the environment. Human impact on biochemical cycles. 2

Lec5 Ecological classification of organisms. 3

Lec6 Organic farming. Healthy food and dietary supplements. 2

Lec7 GMO - genetically modified organisms. 3

Lec8 Written test no. 1 1

Lec9 Waste: types, waste management, recycling. 2

Lec10 Production, recovery and recycling of metals.

Lec11 Climate changes and their reasons. 3

Lec12 Renewable energy. 2

Lec13 Clean transportation. 1

Lec14 Environmental disasters: natural and anthropogenic. 2

Lec15 Written test no. 2. 2

Total hours 30

TEACHING TOOLS USED


N2 Homework related with the chosen lecture.

EVALUATION OF SUBJECT EDUCATIONAL EFFECTS ACHIEVEMENT- lecture Evaluation

(F– forming (during

semester),

C– concluding (at semester

end)

Educational effect

number

Way of evaluating educational effect achievement

F1 PEK_W01, PEK_W02,

PEK_W03

Written test no. 1, for each effect 2 topics with max. 5

points, total 30 pts.

F2 PEK_W04, PEK_W05,

PEK_W06,

Written test no. 2, for each effect 2 topics with max. 5

points, total 30 pts.

F3 PEK_W01 - PEK_W06 Written homework on the chosen topic included in the

program of lectures – The total points - 40 points.

C PEK_W01 – PEK_W06 C = 3.0 if (F1 + F2 + F3) = 50 – 59.5 pts.

3.5 if (F1 + F2 + F3) = 60 – 69.5 pts.

4.0 if (F1 + F2 + F3) = 70 – 79.5 pts.

4.5 if (F1 + F2 + F3) = 80 – 89.5 pts.

5.0 if (F1 + F2 + F3) = 90 – 94.5 pts.

27

5.5 if (F1 + F2 + F3) > 94.5 pts.


PRIMARY LITERATURE:

[1] C. J. Krebs, Ekologia, Wydawnictwo Naukowe PWN, 2011.

[2] A. Mackenzie, A. S. Ball, S. R. Virdee, Ekologia – krótkie wykłady, Wydawnictwo Naukowe PWN,

Warszawa 2005.

[3] J. B. Harborne, Ecological biochemistry, Wyd. Naukowe PWN, Warszawa 1997.

[4] S. Więckowski, General ecology, Oficyna Wydawnicza Branta, Bydgoszcz 1999.


[1] Strona internetowa dotycząca środowiska w Unii Europejskiej: www.eea.eu.int/.

[2] Strona internetowa Ministerstwa Ochrony Środowiska: www.mos.gov.pl/

[3] Strona internetowa Polskiej Agencji Informacji i Inwestycji: www.paiz.gov.pl

SUBJECT SUPERVISOR (NAME AND SURNAME, E-MAIL ADDRESS)

dr Katarzyna Sobianowska, mail: [email protected]

MATRIX OF CORRELATION BETWEEN EDUCATIONAL EFFECTS FOR SUBJECT Ecological chemistry.


Chemistry

Subject

educational

effect



effects defined for

main field of study/ specialization

Subject

objectives

Programme

content

Teaching tool

number

PEK_W01 Optional course C1

Lec1-Lec5,

Lec11 N1, N2

PEK_W02

C1, C2,

C3 Lec2-Lec5

N1, N2

PEK_W03

C1, C2,

C4 Lec6, Lec7

N1, N2

PEK_W04 C1, C2 Lec9, Lec10 N1, N2 PEK_W05 C1, C2 Lec11 N1, N2 PEK_W06 C1,C5 Lec13-Lec15 N1, N2

http://www.eea.eu.int/

http://www.mos.gov.pl/

28

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish: Chemia i technologia pierwiastków f-elektronowych

Name in English: Chemistry and technology of f-electron elements Main field of study (if applicable): Chemistry



level, full-time

Kind of subject optional




Number of hours of


University (ZZU) 30




with grade


(X) final course




points for direct teacher-student

contact (BK) classes 1


PREREQUISITES RELATING TO KNOWLEDGE, SKILLS AND OTHER COMPETENCES

1. Knowledge of the basis of inorganic and physical chemistry

SUBJECT OBJECTIVES

C1 Familiarization students with physicochemical properties of lanthanides and acinides

C2 Acquainting students with minerals of lanthanides and actinides

C3 Familiarization students with methods of leaching and separation of lanthanides and

actinides

C4 Familiarization students with technology of lanthanides and actinides

C5 Acquainting students with different areas of lanthanides and actinides application

C6 Familiarization students with nuclear energy

29



PEK_W01 – knows basic chemistry of lanthanides and actinides (electronic structure,

oxidation states, general characteristics of compounds),

PEK_W02 – knows basic minerals of lanthanides and actinides,

PEK_W03 – knows the methods of mineral leaching and methods that are used for separation

of lanthanides and actinides,

PEK_W04 – knows technological methods that are used for production of lanthanides and

actinides,

PEK_W05 – knows main areas where lanthanides and actinides are applied,

PEK_W06 – has basic knowledge concerning nuclear energy (main reactions, fuel cycle,

types of nuclear reactors, reprocessing of spent nuclear fuel)

PROGRAMME CONTENT


Lec1 Lanthanides – history, abundance, electronic structure, oxidation

states 2

Lec2 Lanthanides – chemistry of water solutions, electronic spectroscopy,

general characteristic of compounds 2

Lec3 Lanthanides – minerals, ores, their benefication and leaching

processes 2

Lec4 Lanthanides – methods of separation 2

Lec5 Lanthanides – oxides, chlorides and fluorides as substrates for metals

production 2

Lec6 Lanthanides – molten salt electrolysis and metallothermy 2

Lec7 Lanthanides – technological methods of metals and alloys production 4

Lec8 Lanthanides - application 2

Lec9 Actinides – history abundance, electronic structure, oxidation states 2

Lec10 Actinides – chemistry of water solutions, electronic spectroscopy,

general characteristic of compounds 2

Lec11 Actinides – minerals, ores, their benefication and leaching processes 2

Lec12 Actinides – technological methods of metals and alloys production 2

Lec13 Nuclear energy 4

Total hours 30

TEACHING TOOLS USED



Evaluation


semester),


achievement

30


semester end)

C1 (lecture) PEK_W01 – PEK_W06 written exam


PRIMARY LITERATURE:

[1]. S. Cotton, „Lanthanides and Actinides”, Macmillan Education Ltd., 1991

[2]. C. Keller, “The Chemistry of Transuranium Elements”, Weinhein, Verlag Chemie 1971

[3]. http://www.chem.ox.ac.uk/icl/heyes/LanthAct/lanthact.html

[4].J. Katz, G.T. Seaborg & L.R. Morss, “The Chemistry of the Actinides”, 2nd

ed., Chapman

& Hall, London, 1986


[1]. „Pierwiastki ziem rzadkich, surowce, technologie, zastosowania”, Ed. W. Charewicz,

WNT, Warszawa 1990

SUBJECT SUPERVISOR


D. Sc. Leszek Rycerz, prof.; [email protected]


FOR SUBJECT

Inorganic Chemistry


Chemistry

Subject

educational effect Correlation between subject




Subject



number***

(knowledge)

PEK_W01

Optional

C1 Lec1-Lec2,

Lec9-Lec10 N1

PEK_W02 C2 Lec3, Lec11 N1

PEK_W03 C3 Lec3-Lec4,

Lec11 N1


Lec12 N1


Lec8 N1

PEK_W06 C6 Lec13 N1



31

Zał. nr 4 do ZW 64/2012

Wroclaw University of Technology


SUBJECT CARD Name in Polish Chemistry and Technology of Nuclear

Materials

Name in English Chemistry and Technology of Nuclear

Materials Main field of study (if applicable) Chemistry





Group of courses YES


Number of hours of






with grade crediting

with grade


(X) final course





student contact (BK) classes 0.5 0.5


COMPETENCES

1. Knowledge of chemistry and physics at the high school level.

2. Knowledge of elementary mathematics.

SUBJECT OBJECTIVES

C1 Teaching students with knowledge about ionizing radiation and protection against

radiation.

C2 Teaching students about nuclear materials used in nuclear energy.

C3 Familiarize students with the chemistry of actinides.

C4 Ability to measure radioactivity in a Geiger-Müller, probe oscillation and a gamma

spectrometer.

C5 Gaining knowledge of hydrometallurgy and uranium and thorium row materials.

C6 Obtain basic knowledge of the nuclear fuel reprocessing.

32



PEK_W01 – knows the basic nuclear law in Poland,

PEK_W02 – be familiar with principles of radiation protection,

PEK_W03 - knows the chemistry of actinides, including uranium and thorium,

PEK_W04 – knows the hydrometallurgy of uranium,

PEK_W05 - has knowledge of the methods for reduction of uranium(VI) to uranium metal,

PEK_W06 - knows chemical metallurgy of thorium,

PEK_W07 - has knowledge in the field of nuclear fuel reprocessing.

Relating to skills:

PEK_U01 – know the basic safety rules in the laboratory radionuclide of open sources,

PEK_U02 – use a Geiger counter, the probe oscillation and gamma-ray spectrometer and

perform basic measurements of quantitative and qualitative uranium and

thorium raw materials,

PEK_U03 – carry out the process of uranium ore leaching,

PEK_U04 – know the basic principles of the solvent extraction of aqueous solutions

containing uranium(VI),

PEK_U05 – has knowledge of separation methods for uranium(VI) using ion ion-exchange

processes,

PEK_U06 – has the ability to reduce uranium(VI) from uranium raw materials using

reduction methods reduction method,

PEK_U07 – knows ways of processing of spent nuclear fuel.

PROGRAMME CONTENT

Form of classes - lecture Number of

hours

Lec 1 Definition of ionizing radiation. Dose and dosage strengths of

ionizing radiation and their SI units and units outside the

arrangement.

1

Lec 2 Exposure to ionizing radiation of alpha, beta, gamma and neutron

type with matter. Types of ionizing radiation shields. 1

Lec 3 Calculations of the thickness of the ionizing radiation shields for

alpha, beta, gamma and neutron type of radiation. 1

Lec 4 Principles and methods of measurements of ionizing radiation:

ionizing, scintillation, semiconductor, chemical and photographic. 1

Lec 5 Radioisotope laboratories: classification and requirements. The

organization of the radiological workshop, controlled and

supervised area.

1

Lec 6 Nuclear law in the European Union and Poland - laws and

executive acts. 1

Lec 7 Nuclear materials used in nuclear powers - nuclear fuel,

moderators, absorbents of neutrons and shielding materials. 2

Lec 8 Actinides chemistry. 2

33

Lec 9 Hydrometallurgy of uranium and thorium. 2

Lec 10 Processing of nuclear fuel. 2

Lec 11 Final test 1

Total hours 15

Form of classes - laboratory Number of

hours

Lab 1 Rules for working in the isotopic laboratory. Safety rules and basics

techniques for working with radioactive substances. 2

Lab 2 Radioactive measurements of uranium and thorium raw materials with

multichannel gamma spectrometer. 2

Lab 3 Leaching of uranium raw materials 2

Lab 4 Solvent extraction of uranium (VI) from aqueous solutions. 2

Lab 5 Leaching of thorium from from thorium raw materials. 2

Lab 6 The receiving of uranium from aqueous solutions by reduction processes. 2

Lab 7 Calculation and construction of shields against ionizing radiation. 2

Lab 8 Final test 1

Total hours 15

TEACHING TOOLS USED


N2 The use of radionuclide laboratory in practice.

N3 The use of hydrometallurgical methods for uranium and thorium raw materials.

N4 A problem solution for ionizing radiation and radiation protection.


LECTURE

Evaluation


semester),

C – concluding

(at semester end)

Educational

effect number Way of evaluating educational

effect achievement

F1 PEK_W01 -

PEK_W07

Written test, from each effect for 1 topic

with maximum 7 points. Total – 49 points.

F2 PEK_W01 -

PEK_W07

Written report for one chosen topic of

lecture program. Maximum - 51 points

C PEK_W01 –

PEK_W07

C = 3.0 if (F1 + F2) = 50 – 59.5 pts.

3.5 if (F1 + F2) = 60 – 69.5 pts.

4.0 if (F1 + F2) = 70 – 79.5 pts.

4.5 if (F1 + F2) = 80 – 89.5 pts.

5.0 if (F1 + F2) = 90 – 94.5 pts.

34

5.5 if (F1 + F2) > 94.5 pts.


LABORATORY

Evaluation

F – forming

(during semester),

C – concluding

(at semester end)

Educational effect

number

Way of evaluating educational effect achievement

F1 PEK_U01 Written raport from Lab 1, max. 5 pts.







F8 PEK_U01 Written test from Lab 1, max. 5 pts.







F15 PEK_U01 – PEK_U07 Final test - 30 pts.

P PEK_U01 –PEK_U07 P = 3.0 if (F1 + F2 + .. + F14 + F15) = 50 – 595 pts.

P = 3.5 if (F1 + F2 + .. + F14 + F15) = 60 – 69.5 pts.

P = 4.0 if (F1 + F2 + ...+ F14 + F15) = 70 – 79.5 pts.

P = 4,5 if (F1 + F2 + ...+ F14 + F15) = 80 – 89.5 pts.

P = 5.0 if (F1 + F2 + .. + F14 + F15) = 90 – 94.5 pts.

P = 5.5 if (F1 + F2 + .... + F14 + F15) > 94.5 pts.


PRIMARY LITERATURE:

1. F. Habashi, A Textbook of Hydrometallurgy, Metallurgie Extractive Quebec,

Quebec, 1993.

2. L.R. Morss, N.M. Edelsteln, J. Fuger, The chemistry of actinides and transactinides

elements, Springer, 2010.

3. W. Szymański, Nuclear chemistry (in Polish), PWN, Warszawa, 2006.

4. Instructions for laboratory exercises „Chemistry and Technology of Nuclear

Materials”, Wroclaw University of Technology, 2012.


1. Agency of Polish Atomic Energy: www.paa.gov.pl.

2. Portal of Atomic Energy in Poland: www.nuclear.pl.

3. Law Portal: www.lex.com.pl.

http://www.paa.gov.pl/

http://www.nuclear.pl/

http://www.lex.com.pl/

35

SUBJECT SUPERVISOR


Prof. Wladyslaw Walkowiak, [email protected]

MATRIX OF CORRELATION BETWEEN EDUCATIONAL EFFECTS FOR SUBJECT

Chemistry and technology of nuclear materials AND EDUCATIONAL EFFECTS FOR MAIN FIELD OF STUDY

Chemistry – Chemical Metallurgy Subject

educational

effect

Correlation between subject educational

effect and educational effects defined for

main field of study and specialization

Subject

objectives

Programme

content

Teaching tool

number

PEK_W01 S2Ach5_W08, X2A_W01, X2A_W03,

X2A_W05, X2A_W07, InzA_W01 C1

Lec1, Lec3,

Lec5 N1, N4


X2A_W05, X2A_W07, InzA_W01 C4

Lec2, Lec4,

Lec6 N1, N4


X2A_W05, X2A_W07, InzA_W01 C2, C3 Lec7, Lec8 N1


X2A_W05, X2A_W07, InzA_W01 C5 Lec9 N1, N3


X2A_W05, X2A_W07, InzA_W01 C5 Lec9 N1


X2A_W05, X2A_W07, InzA_W01 C5 Lec8 N1, N3


X2A_W05, X2A_W07, InzA_W01 C6 Lec10 N1

PEK_U01 S2Ach5_U08, X2A_U01, X2A_U02,

InzA_U01 C1 Lab1, Lab7

N1


InzA_U01 C1, C2 Lab2

N1, N2


InzA_U01 C1, C2 Lab3 N1, N2




InzA_U01 C2, C3 Lab5

N1, N2




InzA_U01 C2, C3 Lab7, Lec7 N1, N2

36

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish Chemia kombinatoryczna

Name in English Combinatorial chemistry Main field of study (if applicable) Chemistry







Number of hours of


University (ZZU) 30




with grade


(X) final course





student contact (BK) classes 0.5



COMPETENCES

2. Knowledge of chemistry corresponding to the BSc degree at the Faculty of

Chemistry.

SUBJECT OBJECTIVES

C1 Knowledge of modern techniques and methods of synthesis of organic compounds

libraries in solution and on a solid support.

C2 Examples of their application in the development of compounds of the targeted

biological activity or physicochemical properties

C3 Presentation of combinatorial synthetic methodologies leading to low molecular

weight compounds and natural oligomers.

37



The person who completed the course:

PEK_W01 – knows the basic theory on the construction and the use of solid polymer

supports, understands the role and advantages of immobilization,

PEK_W02 – knows methodologies of obtaining and deconvolution of chemical libraries in

solution and on a solid support,

PEK_W03 – got to known examples of combinatorial chemistry application in the

development of a product of targeted physicochemical properties,

PEK_W04 – understands the role of combinatorial synthesis in the development of new

drugs,

PEK_W05 – is familiar with traditional and combinatorial synthesis of peptides,

oligonucleotides, and oligosaccharides,

PEK_W06 – got to known instrumental techniques of combinatorial chemistry used in the

synthesis and analysis of the products.

PROGRAMME CONTENT


Lec 1 Introduction to combinatorial chemistry. Basic concepts. Traditional

chemistry versus parallel and combinatorial synthesis. 2

Lec 2 Combinatorial libraries in solution. Indexed libraries. Scaffolds. 2

Lec 3 Structure and examples of solid supports. Polymer resins.

Merrifield, Wang, Mitchell and Rink resin. Structure and function of

linkers and spacers.

2

Lec 4 Strategies for the synthesis of peptides on a solid support. Protecting

groups, coupling agents. Advantages of immobilization.

Instrumentation and apparatus.

2

Lec 5 Peptide libraries. Preparation by coupling of isokinetic mixtures and

"mix and split" method. Examples of application. 2

Lec 6 Libraries of oligonucleotides. Flow synthesis. Microarrays. Phage

display. 2

Lec 7 Classical and combinatorial synthesis of oligosaccharides on a solid

support. Sugar units as a "scaffold". Soluble solid support. 2

Lec 8 Methods of deconvolution of combinatorial libraries. Isolation of the

active component. 2

Lec 9 Determining the structure of the active compound. Instrumental

techniques. Tags. Encoded libraries. 2

Lec 10 Organic synthesis on a solid support. Immobilized reagents.

Examples of low molecular weight compound libraries. 2

Lec 11 Multicomponent reactions. Isonitriles. Passerini and Ugi

condensations. 2

Lec 12 Combinatorial chemistry in drug design. 2

Lec 13 Other applications: catalysis, materials science. 2

Lec 14 Instrumentation of combinatorial chemistry. Automated synthesis. 2

Lec 15 Analytical techniques in the characterization of combinatorial 2

38

libraries.

Total hours 30

TEACHING TOOLS USED

N1 lecture with multimedia presentation


Evaluation


semester),


semester end)


achievement

C PEK_W01 – PEK_W06 multimedia presentation


PRIMARY LITERATURE:

[14] Molecular Diversity and Combinatorial Chemistry: Principle and Applications (M. C.

Pirrung Ed.); Elesevier, 2004.

[15] Combinatorial Chemistry and Technologies: Methods and Applications (G. Fassina, S.

Miertus Eds); Taylor and Francis, 2005.

[16] A. Furka. Combinatorial Chemistry. Principles and Techniques,

http://members.iif.hu/furka.arpad/BookPDF.pdf


[7] Combinatorial Chemistry: Synthesis, Analysis, Screening (G. Jung Ed.); Wiley, 2001.

[8] Combinatorial Chemistry: From Theory to Application (W. Bannwarth, B. Hinzen

Eds.); Wiley, 2005.

SUBJECT SUPERVISOR


Artur Mucha, [email protected]


FOR SUBJECT

Combinatorial Chemistry


all fields of Faculty of Chemistry

39

Subject

educational

effect





Subject



number***

(knowledge)

PEK_W01 elective C1 Lec 1, Lec 3 N1

PEK_W02 C1 Lec 2, Lec 4 –

Lec 11 N1

PEK_W03 C2, C3 Lec 5 – Lec 7,

Lec 12, Lec 13 N1

PEK_W04 C2, C3 Lec 12 N1

PEK_W05 C2, C3 Lec 4 – Lec 7 N1

PEK_W06 C1

Lec 5, Lec 6,

Lec 9, Lec 14,

Wy15

N1



40

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish Krystalografia

Name in English Crystallography Main field of study (if applicable) Chemistry

Specialization (if applicable) Medicinal chemistry, Chemical metallurgy,

Organic and polymer chemistry






Number of hours of






with grade* Examination

/ crediting

with grade*

Examination

/ crediting

with grade*

Examination

/ crediting

with grade* For group of courses mark

(X) final course





student contact (BK) classes 1 0.5



COMPETENCES

3. Knowledge of 1st level degree inorganic and organic chemistry.

4. Knowledge of analytical geometry and group theory at a basic level.

SUBJECT OBJECTIVES

C1 To provide the students with a basic knowledge of Crystallography.

C2 To make the students understand the intermolecular interactions in the context of

solid state molecular organization.

C3 To make the students familiar with the crystal systems, symmetry operations as well

as with the crystallographic point and space groups.

C4 To make the students familiar with some basic inorganic crystal structures.

C5 To make the student s familiar with the basis of the X-ray diffraction measurements

and analysis.

C6 To make the students familiar with Cambridge Structural Data Bases (CSD) and

their importance for structural studies..

41



PEK_W01 – The student knows the basic conception of a crystal and a crystal lattice.

PEK_W02 – The student knows the basic intermolecular interactions and understands their

character.

PEK_W03 – The student knows the macroscopic and structural symmetry elements and

operations in the crystal and understands their combinations.

PEK_W04 – The student knows the 32 crystal point groups and understands the crystal

space groups.

PEK_W05 – The student knows the basic metallic, covalent and ionic structures.

PEK_W06 – The student knows the X-ray diffraction theory and the basic diffraction

equations

PEK_W07 – The student has some knowledge about crystal diffraction measurements and

structure solutions.

PEK_W08 – The student has some knowledge about Crystallographic Data Bases.

Relating to skills:

PEK_U01 – The student knows how to use the resources of the Cambridge Structural

Database.

PEK_U02 – The student is able to define the Miller indices.

PEK_U03 – The student is able to read the information inhibited in the space group symbol.

PEK_U04 – The student is able to distinguish centrosymmetric, noncenrosymmetric and

chiral space groups.

PEK_U05 – The student is able to use the International Tables for Crystallography.

…

Relating to social competences: PEK_K01

PEK_K02

…

PROGRAMME CONTENT


Lec 1 Introduction to the course of crystallography. Vectors and matrices

in crystallography. Coordinate systems in crystallography and

crystallographic calculations.

2

Lec 2 The symmetry: Symmetry elements and symmetry operations. The

symmetry of the finite sets. 2

Lec 3 The crystal lattice theory: primitive and complex networks. Lattice

planes and crystal directions: Miller indices and zone axis symbols.

The unit cell and the crystal systems. Indexing in trigonal and

hexagonal systems.

2

Lec 4 Two- and three-dimensional lattices and symmetry. The five plane

lattices; the seventeen plane groups. One-dimensional symmetry: 2

42

border or frieze patterns. The fourteen Bravais lattices and the

crystal systems. The reciprocal lattice.

Lec 5 Crystal symmetry. Stereographic projections. Lattice and crystal

point symmetry and symmetry elements. The 32 crystallographic

point groups. The symmetry classifications of crystal systems.

2

Lec 6 Crystal morphology and geometrical crystal shapes : open and

closed crystal shapes. Symmetry of the crystal polyhedrons and

symbols of the polyhedron walls.

2

Lec 7 Crystal space symmetry: Translational symmetry; screw rotations

and glide planes. International symbols. 2

Lec 8 The 17 crystallographic space groups of two-dimensional lattices.

Ortogonal projections. General and special positions. 2

Lec 9 The tree-dimensional space groups. International symbols.

Interpretation the information from the International

Crystallographic Tables.

2

Lec 10 Crystal organization and lattice energy. Chemical bonding and

intermolecular interactions. 2

Lec 11 Classification of solid state structures: hexagonal layer and close

packed crystal structures: hcp, ccp, bcc structures. Octahedral and

tetrahedral interstices and their positions in closed packed structures.

Atomic radius. Basic metallic structures.

2

Lec 12 Some important ionic structures and covalent structures. 2

Lec 13 Crystal diffraction: X-ray diffraction. The Laue equations. The

Bragg’s equation; higher order of diffraction; the quadratic form of

Bragg equation. The Ewald reflecting sphere construction.

2

Lec 14 Crystal diffraction: Atom displacement factors. Structure factors.

Symmetry of the diffraction patterns – the Laue groups, systematic

absences

2

Lec 15 Cambridge Crystallographic Data Base. Analysis of crystal

structures 2

Total hours 30


Cl 1 Vectors in crystallography: bases vectors and coordinates; the scalar and

the vector product. Matrices in crystallography: matrix operations; matrix

transformation; determinant; the inverse of a matrix. 1

Cl 2 Coordinate systems in crystallography. Change of bases. Unit cell basis

and orthonormal basis. Identity of vector triple product and scalar triple

product. 1

Cl 3 Symmetry operations: Stereographic projections; matrix representation;

combined and coupled symmetry operations. 1

Cl 4 Defining the Miller indices of axes and planes. The zone axes symbol. 1

Cl 5 Geometrical calculations. Determining distances and angles in the unit

cell. Determining the cell volume. 1

Cl 6 Symmetry classification of crystal systems. The Miller-Bravais symbons

in hexagonal system. 1

Cl 7 Combination of symmetry elements. Crystallographic point groups . Point

group stereograms. Stereographic projections of the crystal polyhedrons. 1

43

Cl 8 Symmetry of the plane lattices. Two-dimensional space groups. Preparing

the orthogonal projections of the 17 plane groups. 1

Cl 9 Symmetry of the three-dimensional lattices. Three-dimensional space

groups. Interpretation information of the space group symbol. 1

Cl 10 Close packed structures. Atomic packing factor, volume of the interstices:

calculations 1

Cl 11 Two-component structures - calculations 1

Cl 12 Bragg equation. Calculations 1

Cl 13 Systematic absence of reflections. Laue groups. 1

Cl 14 -

Cl 15

Crystallographic Data Base Cambridge 2

15

…

Total hours

TEACHING TOOLS USED

N1 Lectures in the Internet.

N2 Multimedia presentations

N3 The use of specialized software.

N4 Troubleshooting tasks

N5 Consultation

…


Evaluation


semester),


semester end)

Educational effect


achievement

F1 (lectures) PEK_W01

PEK_W08

exam

F1 (exercise) PEK_U02-

PEK_U05

colloquium

F2 (activity) PEK_U02-

PEK_U05

C(exercise) = 0.8F1 + 0.2F2

44


PRIMARY LITERATURE:

[9] Dennis W. Bennett, Understanding Single-Crystal X-Ray Crystallography, Wiley-

VCH, 2010.

[10] Christopher Hammond, The Basics of Crystallograaphy and Diffraction, 3rd

Eddition, IUCr, Oxford University Press, 2011.

[11] Werner Massa, Crystal Structure Determination, Springer, Berlin, 2004.

[12] J. Glusker and K. Trueblood, Crystal Structure Analysis, Oxford Science

Publication, 2010 .


[13] Zygmunt Trzaska Durski i Hanna Trzaska Durska, Podstawy Krystalografii,

PANalytical, Warszawa 2003.

[14] Zygmunt Trzaska Durski i Hanna Trzaska Durska, Podstawy Krystalografii

strukturalnej i rentgenografii, PWN, Warszawa, 1994.

[15] Z. Bojarski, M Gigla, K. Stróż, M. Surowiec, Krystalografia, PWN,

Warszawa 1996.

[16] Z. Bojarski, M Gigla, K. Stróż, M. Surowiec, Krystalografia, PWN,

Warszawa 2007.

SUBJECT SUPERVISOR


Prof. dr hab. Veneta Videnova-Adrabińska, [email protected]


FOR SUBJECT

Crystallography


Chemistry

Subject

educational

effect





Subject



number***

(knowledge)


PEK_W02 K2Ach_W04 C2 Lec 10 - Lec 12 N1, N2

PEK_W03 K2Ach_W04 C3 Lec 2, Lec 7 N1, N2

PEK_W04 K2Ach_W04 C3 Lec 4, Lec 5, Lec

8 N1, N2

PEK_W05 K2Ach_W04 C2, C4 Lec 11, Lec 12 N1, N2

PEK_W06 K2Ach_W04 C5 Lec 13, N1, N2

45



(skills)

PEK_U01 K2Ach_U04 C6 Cl 1-Cl 15 N3

PEK_U02 K2Ach_U04 C3 Cl 3- Cl 5 N2, N4

PEK_U03 K2Ach_U04 C3 Cl 2- Cl 9 N2, N4

PEK_U04 K2Ach_U04 C3, C4 Cl 2- Cl 9 N2, N4

PEK_U05 K2Ach_U04 C1, C3, C5 Cl 9 N2, N4

(competences)

PEK_K01

PEK_K02

PEK_K03

…



46

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish: Elektrochemia

Name in English: Electrochemistry Main field of study (if applicable): Chemistry



level, full-time





Number of hours of






with grade crediting with

grade


(X) final course





contact (BK) classes 0.5 0.5




SUBJECT OBJECTIVES

C1 Familiarization students with general knowledge concerning electrochemistry

C2 Acquainting students with properties of electrolytes

C3 Familiarization of students with electrode potentials and galvanic cells

C4 Familiarization of students with phenomenon of corrosion and protection against

corrosion

C5 Acquainting students with industrial electrochemical processes

C6 Teaching students a practical performing of electrochemistry experiments.

C7 Familiarization of students with principles of selection of parameters of selected

electrochemical processes

47

C8 Familiarization students with ways of experimental results interpretation.

C9 Acquainting students with safety and laboratory rules.



PEK_W01 – knows basic definitions, principles and concepts of electrochemistry,

PEK_W02 – has basic knowledge about electrical conductivity of electrolytes, interionic

interactions and structure of phase boundaries,

PEK_W03 – has a general knowledge about electrode potentials and galvanic cells

PEK_W04 – knows reasons for electrochemical corrosion, types of corrosion cells and

possibilities of protection against corrosion,

PEK_W05 – knows most important industrial electrochemical processes

Relating to skills:

PEK_U01 – is capable to perform practically laboratory experiment

PEK_U02 – knows how to perform chemical analysis of selected products of process under

investigation

PEK_U03 – can operate basic equipment used in laboratory

PEK_U04 – can make interpretation and discuss obtained experimental results and find

conclusion

PEK_U05 – follows safety and laboratory rules

PROGRAMME CONTENT


Lec1 Electrochemistry – foundation, definitions and concepts 2

Lec2 Electrical conductivity and interionic interactions 2

Lec3 Electrode potentials and double layer structure on phase boundaries 2

Lec4 Electrical potentials and electric current 2

Lec5 Galvanic cells – properties, function and construction 2

Lec6 Corrosion 2

Lec7 Industrial electrochemical processes 3

Total hours 15

Form of classes - laboratory Number

of hours

Lab 1 Safety and laboratory rules. General description of laboratory exercises to

be done – practical and theoretical remarks.

3

Lab 2 Activity series of metals 3

Lab 3 Determination of the electrical conductivity of electrolyte 3

Lab 4 Measurement of electromotive force 3

Lab5 Corrosion tests of metallic materials 3

Total hours 15

48

TEACHING TOOLS USED


N2 Performing of experiments

N3 Preparation of report


Evaluation


semester),


semester end)


achievement

C1 (lecture) PEK_W01 – PEK_W05 written test

F1 (laboratory) PEK_U01 – PEK_U05 Small written exams

F2 (laboratory) PEK_U01 – PEK_U05 Reports

C2 (laboratory) = (F1+F2)/2


PRIMARY LITERATURE:

[1]. C.H. Hamman, A. Hamnett, W. Vielstich, Electrochemistry. Second, Completely Revised

and Updated Edition., Wiley-VCH 2007

[2]. H.H. Girault, Analytical and Physical Electrochemistry, Marcel Dekker Ltd, 2004

[3]. A.J. Bard and L.R. Faulkner, Electrochemical Methods: Fundametals and Applications,

2nd Edition, Wiley, 2001.


[1]. P.W. Atkins and J. de Paula, Physical Chemistry, 7th Edition, Oxford 2002

other handbooks and Internet sources

SUBJECT SUPERVISOR




FOR SUBJECT

Electrochemistry


Chemistry

49

Subject





Subject



number***

(knowledge)






(skis)


PEK_U02 S2Ach5_U06 C6-C7 Lab1-Lab5 N2-N3



PEK_U05 S2Ach5_U06 C9 Lab1 N2



50

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish: Elektrometalurgia

Name in English: Electrometallurgy Main field of study (if applicable): Chemistry



level, full-time





Number of hours of






with grade crediting with

grade


(X) final course





contact (BK) classes 1 1




SUBJECT OBJECTIVES

C1 Familiarization students with general knowledge concerning electrometallurgy

C2 Acquainting students with properties surface morflorogy of electrodeposits and

current distribution in electrochemical cells

C3 Familiarization of students with theoretical aspects and technological schemes of

electrowinning and electrorefining

C4 Familiarization of students with processes of electroplating and deposition of metals

without current

C5 Acquainting students with electrometallurgical processes in molten salts and

environmental issues of electrometallurgy

51

C6 Teaching students a practical performing of unit processes of electrometallurgy in

laboratory scale together with chemical analysis of selected products of process.


electrometallurgical processes

C8 Teaching of way of results presentation and discussion




PEK_W01 – knows basic definitions, principles and concepts of electrometallurgy,

PEK_W02 – has basic knowledge about surface morflorogy of electrodeposits and current

distribution in electrochemical cells,

PEK_W03 – has a general knowledge concerning electrowinning and electrorefinning

PEK_W04 – knows technological aspects of electroplating and deposition of metals without

current,

PEK_W05 – knows electrometallurgical processes in molten salts and environmental issues

of electrometallurgy

Relating to skills:



investigation

PEK_U03 – can operate basic equipment used in laboratory


conclusion


PEK_U06 –is capable to present experimental results as multimedia presentation

PROGRAMME CONTENT


Lec1 Electrometallurgy – definitions, principles and concepts 2

Lec2 Surface morfology of metal electrodeposits 4

Lec3 The current distribution in electrochemical cells 4

Lec4 Electrodeposition at a periodically changing rate 2

Lec5 Electrowinning – theoretical aspects and technological scheme of zinc

electrowinning 4

Lec6 Electrorefining – theoretical aspects and technological scheme of

copper refining 4

Lec7 Electroplating and surface finishing 2

Lec8 Metal deposition without external current 2

Lec9 Electrodeposition of metals from molten salts 4

Lec10 Environmental issues of electrometallurgy 2

Total hours 30

52

Number of hours

Form of classes - laboratory Number

of hours

Lab 1 Safety and laboratory rules. General description of laboratory exercises to

be done – practical and theoretical remarks.

3

Lab 2 Electrolysis of copper solutions 6

Lab 3 Electrorefining of copper 6

Lab 4 Electroplating with silver 6

Lab5 Molten salt electrolysis – production of cerium 6

Lab6 Multimedia presentation (presentation of experimental results) 3

Total hours 30

TEACHING TOOLS USED


N2 Solving of computational problems



N5 Multimedia presentation


Evaluation


semester),


semester end)


achievement


F1 (laboratory) PEK_U01 – PEK_U05 Small written exams

F2 (laboratory) PEK_U01 – PEK_U05 Reports

F3 (laboratory) PEK_U06 Multimedia presentation

C2 (laboratory) = (F1+F2+F3)/3


PRIMARY LITERATURE:

[1]. K.I. Popov, S.S. Djokic, B.N.Grgur, Fundamental Aspects of Electrometallurgy, Kluver

Academic/Plenum Publishers 2002



53

SUBJECT SUPERVISOR




FOR SUBJECT

Inorganic Chemistry


Chemistry

Subject





Subject



number***

(knowledge)






(competences)P

PEK_U01 S2Ach5_W04 C6 Lab2-Lab5 N2-N4





PEK_U06 S2Ach5_W04 C8 Lab6 N5



54

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish Praca dyplomowa I

Name in English Graduate laboratory I Main field of study (if applicable) all fields of study at Faculty of Chemistry

Specialization (if applicable)






Number of hours of


University (ZZU) 60




with grade


(X) final course








COMPETENCES

5. Theoretical and practical knowledge required for the degree program being studied

6.

SUBJECT OBJECTIVES

C1 Get to know the basic methodology of scientific work

C2 Acquisition of the ability to use the scientific literature and other sources of

knowledge.

C3 Increasing knowledge in a specialized field being studied

55



Student:

PEK_W01 – knows the types of sources of scientific knowledge and expertise,

PEK_W02 - has in-depth knowledge in the area of the thesis topics.

Student:

Relating to skills:

PEK_U01 – able to collect and verify the information useful to know a particular issue,

PEK_U02 – can combine and generalize information from different sources,

PEK_U03 – able in a concise and critical to develop the information collected,

PROGRAMME CONTENT


La 1-

15 Individual student's work according to the schedule agreed with the

thesis supervisor. 60

Total hours 60

TEACHING TOOLS USED

N1 consultations


Evaluation


semester),


semester end)

Educational effect


achievement

C PEK_W01

PEK_W02

PEK_U01 –

PEK_U03

evaluation of the quantity and quality of

student work


[17] The scientific and professional literature designated by the Supervisor and / or found

by the student.

SUBJECT SUPERVISOR


Card preparation: Piotr Drożdżewski, [email protected]

56


FOR SUBJECT

Graduate laboratory I


(all fields of study)

Subject

educational

effect





Subject



number***

(knowledge)

PEK_W01

K2Abt_U02, K2Ach_U05,

K2Aic_U02, K2Aim_U06, K2Atc_U09 C2 La1-La15 N1

PEK_W02 K2Abt_U02, K2Ach_U05,


(skills)

PEK_U01


K2Aic_U02, K2Aim_U06, K2Atc_U09 C1, C2 La1-La15 N1

PEK_U02 K2Abt_U02, K2Ach_U05,






57

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish Praca dyplomowa II

Name in English Graduate laboratory II Main field of study (if applicable) all fields of study at Faculty of Chemistry







Number of hours of


University (ZZU) 225




with grade


(X) final course








COMPETENCES


8.

SUBJECT OBJECTIVES

C1 Get to know the basic methodology of scientific work

C2 Gaining the skills of planning, carrying out and analyzing the results of scientific

experiments

C3 Increasing knowledge in a specialized field being studied

C4 Inspiring students to their further development and continuous self-education.

C5 Deepening the ability to create a written document presenting the current state of

knowledge and their own achievements in the field of thesis topic.

58



Students:

PEK_W01 – knows the types of sources of scientific knowledge and expertise,

PEK_W02 - has theoretical and practical knowledge necessary to perform the thesis

Students:

Relating to skills:

PEK_U01 – able to carry out experiments / perform project / build software and develop the

results and draw conclusions from their achievements,

PEK_U02 – able to prepare a written paper on a selected scientific topic in and their

contribution to this issue

PEK_U03 –can find new and develop their existing interests and skills.

PROGRAMME CONTENT


La 1-

15 Individual student's work according to the schedule agreed with the

thesis supervisor. 60

Total hours 60

TEACHING TOOLS USED

N1 consultations


Evaluation


semester),


semester end)

Educational effect


achievement

C PEK_W01

PEK_W02

PEK_U01 –

PEK_U03

evaluation of the quantity and quality of

student supervisor after submission of the

final written version of the study entitled:

Diploma Thesis


[18] The scientific and professional literature designated by the Supervisor and / or found

by the student.

SUBJECT SUPERVISOR



59


FOR SUBJECT

Graduate laboratory II



Subject

educational

effect





Subject



number***

(knowledge)

PEK_W01



PEK_W02 K2Abt_U03, K2Ach_U06,


(skills)

PEK_U01









60

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish Seminarium dyplomowe (+ praca dyplomowa +

przygotowanie do egzaminu dyplomowego)

Name in English Graduation seminar and thesis preparation Main field of study (if applicable)







Number of hours of


University (ZZU) 15




with grade For group of courses mark

(X) final course








COMPETENCES


10.

SUBJECT OBJECTIVES

C1 Skills of oral presentation of own work results

C2 Skills of written presentation own research results.

C3 Get to know the form of a public discussion with regard to defend own views and

ideas.

C4

61



Student:

PEK_W01 – has in-depth knowledge of the thesis topic.

Student:

Relating to skills:

PEK_U01 – can use specific computer tools to prepare a multimedia presentation

PEK_U02 – can submit their prepared multimedia presentations to the public.

PEK_U03 – able to publicly present the results of own achievements, and to defend them

during the public discussion.

PROGRAMME CONTENT

Form of classes - seminar Number of hours

Sem

1-15 Presentation of multimedia presentation and participate in the

discussion 15

Total hours 15

TEACHING TOOLS USED

N1 consultations

N2 multimedia presentation

N3 oral presentation


Evaluation


semester),


semester end)

Educational effect


achievement

C PEK_W01

PEK_U01 –

PEK_U03

evaluation of oral presentation and

activities in the discussions


PRIMARY LITERATURE:

[17] none


[19] none

[20]

62

SUBJECT SUPERVISOR




FOR SUBJECT

Graduate seminar.



Subject

educational

effect





Subject



number***

(knowledge)

PEK_W01


K2Aic_U27, K2Aim_U34, K2Atc_U36 C3 Se1-Se15 N1

(skills)

PEK_U01






K2Aic_U27, K2Aim_U34, K2Atc_U36 C2, C3 Se1-Se15 N1



63

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish:

Name in English: Hydrogen storage and combustion of fuels Main field of study (if applicable): Chemistry



level, full-time





Number of hours of


University (ZZU) 30




with grade


(X) final course









SUBJECT OBJECTIVES

C1 Familiarization students with hydrogen as a source of energy

C2 Acquainting students with possible ways of hydrogen distribution

C3 Familiarization students with knowledge concerning fuel cells

C4 Acquainting students with possible ways of hydrogen storage

C5 Familiarization students with basics for understanding of combustion of typical fuels

and waste as CHO transformation process.

64

C6 Familiarization students with pyrolysis, gasification and incineration processes.

C7 Acquainting students with technologies such as grate incineration, bed processing,

sequence process: pyrolysis – gasification – oxidation or construction and use of

small, residential appliances.



PEK_W01 – knows physical and chemical properties of hydrogen,

PEK_W02 – knows basic solutions for hydrogen distribution,

PEK_W03 – has knowledge concerning fuel cells and their possible application,

PEK_W04 – knows possible methods of hydrogen storage,

PEK_W05 – has basic knowledge concerning combustion of typical fuels and waste as CHO

transformation process,

PEK_W06 – has knowledge about pyrolysis, gasification and incineration processes,

PEK_W07 – knows technolgies used in combustion of fuels and wastes

PROGRAMME CONTENT


Lec1 Hydrogen production technologies 2

Lec2 Infrastructure for hydrogen distribution and refueling 2

Lec3 Fuel cells: fundamentals and engineering considerations 4

Lec4 Hydrogen storage: fundamentals and engineering considerations 4

Lec5 Life-cycle and Well-to-Wheels analyses of fuel cell vehicles 2

Lec6 Hydrogen safety 1

Lec7 CHO system – understanding of fuel as carbon/hydrogen/oxygen

system. 2

Lec8 Nitrogen, sulfur, chlorine and bromine equilibria at high

temperatures. 2

Lec9 Combustion, gasification, pyrolysis. 2

Lec10 Gasification of biomass and waste. Steam reforming. 2

Lec11 Residential combustion. 2

Lec12 Waste incineration. 2

Lec13 Fractioning of elements. 2

Lec14 Slag, fly ashes and flue gases. 1

Total hours 30

65

TEACHING TOOLS USED



Evaluation


semester),


semester end)


achievement



PRIMARY LITERATURE:

1. Lennie Klebanoff (ed.), Hydrogen Storage Technology: Materials and Applications, CRC

Press 2013 2. W.Wielstich, A. Lamm, H.A. Gasteiger, H. Yokokase, Handbook of Fuel

Cells, Willey 2013 3 S. Sarkar, Fuels and Combustion



SUBJECT SUPERVISOR


prof. Wlodzimierz Szczepaniak; [email protected]

D. Sc. Leszek Rycerz; [email protected]


FOR SUBJECT

Inorganic Chemistry


Chemistry

Subject





Subject



number***

(knowledge)

PEK_W01 Optional C1 Lec1 N1

PEK_W02 C2 Lec2 N1

mailto:[email protected]

66

PEK_W03 C3 Lec3, Lec5 N1

PEK_W04 C4 Lec4-Lec6 N1

PEK_W05 C5 Lec7 N1





67

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish: Hydrometalurgia

Name in English: Hydrometallurgy Main field of study (if applicable): Chemistry



level, full-time





Number of hours of





Form of crediting Examination crediting with

grade


(X) final course





contact (BK) classes 1 1.5



5. Knowledge of the basis of physical chemistry (Lecture Physical Chemistry I)

SUBJECT OBJECTIVES

C1 Familiarization students with theory of chemical equilibrium.

C2 Acquainting students with thermodynamics related to the hydrometallurgical

processes.

C3 Familiarization students with reaction kinetics, process rate, transport phenomena in

hydrometallurgy.

C4 Familiarization students with unit operations of hydrometallurgical processes

C5 Acquainting students with theory of metallurgical processes

C6 Familiarization students with technological processes that are use for production of

Cu, Co, Ni, Au, PGM

C7 Familiarization students with environmental aspects of hydrometallurgy

C8 Teaching students a practical performing of unit processes of hydrometallurgy in

68


C9 Acquainting students with software used for calculation and modeling of

thermodynamic equilibria of chemical reactions from area of hydrometallurgical

processes


hydrometallurgical processes





PEK_W01 – knows basic thermodynamics related to phase equilibria,

PEK_W02 – knows theory of hydrometallurgical processes,

PEK_W03 – knows basis of reaction kinetics, process rate, transport phenomena in

metallurgy ,

PEK_W04 – knows unit operations that are used in hydometallurgy,

PEK_W05 – knows theoretical background of hydometallurgical processes,

PEK_W06 – has basic knowledge concerning metallurgical processes for production Cu, Co,

Ni, Au, PGM Zn,

PEK_W07 – knows environmental aspects of hydrometallurgy.

Relating to skills: PEK_U01 – can prepare alone equipment necessary for laboratory exercise,

PEK_U02 – is capable to run experiment and to take care of its correctness,

PEK_U03 – is able to make interpretation of obtained results and find the conclusion

PEK_U04 – can work in accordance with safety and high-temperature laboratory rules

PEK_U05 – is able to present results of experiments as multimedia presentation

PROGRAMME CONTENT


Lec1 Role of hydrometallurgy in base and precious metals production -

general scope 2

Lec2 Processing and beneficiation of ores and by-products for

hydrometallurgical treatment 2

Lec3 Thermodynamics, equilibria and chemistry in leaching of base and

precious metals 2

Lec4 Electrochemical aspects of leaching of metals and sulphides 2

Lec5 Leaching processes and leaching systems (stirred tanks leaching,

pressure leaching, heap leaching) 2

Lec6 Leaching reactions rates, kinetic models of leaching 2

Lec7 Purification and separation processes for leaching liquors (SX, IX),

Recovering of metals and metal compounds from solutions 2

69

Lec8 Hydrometallurgy of Cu (oxide and sulphide ores and concentrates)

3

Lec9 Hydrometallurgy of Ni and Co – sulphidic and lateritic ores 2

Lec10 Hydrometallurgy of gold (cyanide CIP and CIL leaching, refractory

ores)

2

Lec11 Hydrometallurgy of PGM 2

Lec12 Bioleaching – biometallurgy (Cu, Au) 2

Lec13 Pressure leaching (Cu, Zn, Ni) and pressure precipitation of metals

(Cu, Ni) 2

Lec14 Fe and As control in leaching circuits,

1

Lec15 Economical aspects of application of hydrometallurgy 2

Total hours 30

PROGRAMME CONTENT


Lab1

Materials characterization in hydrometallurgy – leaching feed and

residue (chemical and mineralogical analysis, particle size

distribution, specific acid consumption determination, etc)

6

Lab2

Elemental measurements in extractive metallurgy (thermodynamic

and electrochemical evaluation of the process, microscopy

examination, density, Eh and pH determination, conductivity

measurements, hydrophobicity

6

Lab3

Non-oxidative acidic leaching of copper concentrate (effect of

solid/liquid ratio and carbonates decomposition grade on kinetics of

non-oxidative leaching) 6

Lab4

Atmospheric leaching of copper sulphide concentrates (effect of basic

parameters on kinetics of atmospheric leaching of copper concentrate

by means of acidified iron(III) solution)

6

Lab5

Pressure leaching of copper sulphide concentrates (effect of

temperature and oxygen partial pressure on kinetics of pressure

leaching of copper concentrate by means of acidified iron(III)

solution)

6

Lab6 Solution purification and metals separation by solvent extraction and

ionic exchange 6

Lab7

Electrochemical aspects of sulphide minerals leaching under non-

oxidative and oxidative conditions (woltammetric measurements on

sulphide electrodes, potentiometric measurements of sulphide

electrode in non-oxidative and oxidative conditions),

6

Lab8 Oral presentation (with discussion) of the consolidated report from

tests 3

Total hours 45

70

TEACHING TOOLS USED




N4 Software utilization


N6 Multimedia presentation (presentation of experimental results)


Evaluation


semester),


semester end)


achievement


F1(laboratory) PEK_U01 – PEK_U05 mean value from 7 small written exams

F2 (laboratory) PEK_U01 – PEK_U05 Mean value from 7 lab reports

F3 (laboratory) PEK_U01 – PEK_U05 Multimedia presentation of lab. results

C2(laboratory) PEK_U01 – PEK_U05 (F1+F3+F3)/3


PRIMARY LITERATURE:

1. Hydrometallurgy – Principles and Applications, CRC-CISP-WP 2008,

2. Jackson E. Hydrometallurgical Extraction and Reclamation,

3. Havlik T., Hydrometallurgy – Principles and applications

4. Habashi F. A Textbook of Hydrometallurgy, Gupta C.K.,

5. Mukherjee T.K., Hydrometallurgy in Extraction Processes Vol.1+2,

6. Han K.N., Aqueous Metallurgy, SME 2002,

7. Burkin A.R., Chemical Hydrometallurgy, Imperial College Press, 2001,


1. Marsden J.O., House C.I., The Chemistry of Gold Extraction SME 2006,

2. Yannopoulos J.C. The Extractive Metallurgy of Gold,

3. Rawlings D.E., Johnson D.B. (eds.), Biominig, Springer 2007,

4. Drzymala J., Mineral Processing – Foundations of theory and practice of

minerallurgy, Wroclaw Univ. of Techn., 2007.

Biswas A.K & Davenport W.G. Extractive Metallurgy of Copper

71

SUBJECT SUPERVISOR


Dr Tomasz Chmielewski; [email protected]


FOR SUBJECT

Inorganic Chemistry


Chemistry

Subject





Subject



number***

(knowledge)

PEK_W01 S2Ach5_W06 C1 Lec1, Lec3 N1



PEK_W04 S2Ach5_W06 C4 Lec, Lec5,Lec7 N1




(skills)

PEK_U01 S2Ach5_W06 C8

Lab1-Lab7

N2-N5

PEK_U02 S2Ach5_W06 C8-C9 Lab1-Lab7 N2-N5



PEK_U05 S2Ach5_W06 C11 Lab8 N6



72

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish: Leki Nieorganiczne

Name in English: Inorganic drugs Main field of study (if applicable): Chemistry

Specialization (if applicable): Medicinal Chemistry


Kind of subject: obligatory


Group of courses NO


Number of hours of organized

classes in University (ZZU) 30



Form of crediting credit


(X) final course






contact (BK) classes

1



1. Completed courses in Inorganic Chemistry and Organic Chemistry, 1-st level

SUBJECT OBJECTIVES C1 Learning the fundamental topics and techniques in medicinal chemistry.

C2 Gaining a knowledge about the modern methods in medical diagnostics (PET, MRI, MRA,

SPECT) employing metal compounds and radioisotopes.

C3 Learning the chemical structures, methods of syntheses ad the mechanisms of action of

the inorganic drugs.

C4 Learning the current trends in the development of inorganic drugs.



PEK_W01 Student gains a general knowledge about the contemporary diagnostic techniques used

in medicine: magnetic resonances (MRI and MRA), positron emission tomography (PET),

Single Photon Emission Computed Tomography (SPECT). Knows the metal compounds

and radiopharmaceuticals used in these diagnostic techniques.

PEK_W02 Knows the application of inorganic drugs in the medical therapy.

73

Form of classes – lecture Number of hours

Lec 1 Classification of drugs. Drug targets. Drug discovery, design and

development (clinical trials).

2

Lec 2 Development of Inorganic Drugs. The dose-response relationship.

Bertrand diagram.

2

Lec 3 Inorga Inorganic diagnostic contrast agents. Barium sulfate and iodine

compounds as X-ray contrasts. Instrumentation and the basic

mechanism of Magnetic Resonance Imaging (MRI). Gadolinium(III)

chelates, nanomolecules and iron oxides nanoparticles as T1 and T2

contrast agents in magnetic resonances (MRI and MRA).

2

Lec 4 PET, Positron Emission Tomography. Instrumentation and the basic

mechanism. Radiopharmaceuticals containing F-18, O-15, N-13 and

C-11 as diagnostic agents. Metal-based PET radiotracers: Cu-64,

Rb-82 and Ga-68 labeled compounds. Portable generator for

obtaining the positron emitters (instant kit). Application of PET method.

2

Lec 5 Nuclear medicine and the use of radio-nuclides (gamma - emission).

Scintigraphy and Single Photon Emission Computerized Tomography

(SPECT) in tumor diagnostics. Radionuclide production. Technetium

(Tc-99m), gallium (Ga-67) and indium (In-111) - labeled compounds.

2

Lec 6 Therapeutic radiopharmaceuticals: therapy of cancer with radioisotopes.

The use of the monoclonal antibodies with gamma-emitters. Samarium

(Sm-153) and tin (Sn-117) complexes in bone-pain palliation. Boron-

Neutron Capture (BNC) therapy. Structure and functions of DNA –

an overview.

2

Lec 7 The origin of cancer. The chemical and physical mutagens. Anti-

oncogens, protein p-53, cell apoptosis. Various types of chemotherapy.

Drugs acting directly on DNA: alkylating agents (chlormethine);

intercalators and chain cutters. Bleomycin and the role of a metal ion.

2

Lec 8 Discovery of Cisplatin. Hydrolysis and kinetics of binding to DNA.

Structures of DNA adducts produced by cisplatin. The mechanism of

anticancer activity of cisplatin.

2

Lec 9 II-nd and III-rd generation of cisplatin analogs. Structures of

Carboplatin, Oxaliplatin, Nedaplatin and Picoplatin. Search for an orally

active drug. Pt(II) and Pt(IV) complexes. Syntheses of platinum

complexes.

2

Lec 10 Search for non-platinum antitumor metal complexes. Palladium, titanium

and group 14 metal compounds. Drugs containing arsenic ion. Anticancer

activity of arsenic trioxide (Trisenox) and gallium complexes.

2

Lec 11 Ruthenium complexes for selective treatment of solid tumor metastases.

Syntheses and structures of ruthenium complexes. The mechanisms of

transport and antitumor action of Ru(III) and Ru(II) complexes.

2

Lec 12 Bismuth in medicine, antiulcer and antibacterial properties.

Helicobacter pylori. Mechanism of action of bismuth against H.pylori .

Drugs containing sulphur: sulfonamides, penicillins, cephalosporins.

2

Lec 13 Vanadium complexes for diabetes treatment (replacement of insulin

injections, insulin mimetics). Inorganic vanadium salts (vanadyl sulfate).

Chelated oxovanadium complexes. V-O, V-N and V-S coordination

2

74

vanadyl complexes. Peroxovanadates.

Lec 14 Chrysotherapy. Gold – drug metabolism and immunochemistry. Possible

mechanism of chrysotherapy in rheumatoid arthritis. Use of gold for

other diseases (antitumor activity).

2

Lec 15 Perspectives in medicinal inorganic chemistry 2

Total hours 30

TEACHING TOOLS USED

N1. Lectures with multimedia presentations (slides)


Evaluation (F –

forming (during

semester), P –

concluding (at

semester end)

Educational effect number Way of evaluating educational effect achievement

P PEK_W01- PEK_W02 Final Examination


PRIMARY LITERATURE:

[1] G.L. Patrick, An Introduction to Medicinal Chemistry III ed. Oxford Univ. Press, 2005.

[2] Metallopharmaceuticals I, DNA Interactions Eds. M.J. Clarke, P.J. Sadler (1999).

[3] Metallopharmaceuticals II, Diagnosis and Therapy. Eds. M.J. Clarke, P.J. Sadler (1999).

[4] H.B. Kraatz, N. Metzler-Nolte (Eds.), Concepts and Models in Bioinorganic Chemistry,

2006, Part 2. Medicinal Inorganic Chemistry, pages 25 – 46.

[5] E. Alessio (Ed.) Bioinorganic Medicinal Chemistry, Wiley-VCH, 2011


[1] J.C. Dabrowiak Metals in Medicine. Wiley, 2009 (an electronic version available)

[2] J.L.Sessler, S.R.Doctrow, T.J.McMurry, S.J.Lippard, Medicinal Inorganic Chemistry 2005


prof. zw. dr hab. inż. Danuta Michalska, [email protected]


75

MATRIX OF CORRELATION BETWEEN EDUCATIONAL EFFECTS FOR

A SUBJECT

Inorganic drugs AND EDUCATIONAL EFFECTS FOR MAIN FIELD OF

STUDY Chemistry

AND SPECIALIZATION Medicinal Chemistry Subject educational effect Correlation between subject


effects defined for main field of

study and specialization (if

applicable)**

Subject



number***

Relating to knowledge

PEK_W01 X2A_W06 C2 Lec 3 – Lec 5,

Lec 15

N1

PEK_W02 X2A_W06 C1, C3, C4 Lec1 –Lec2,

Lec 6-15

N1



76

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish Analiza instrumentalna

Name in English Instrumental Analysis Main field of study (if applicable) Chemistry







Number of hours of







with grade


(X) final course





student contact (BK) classes 0,5 2



COMPETENCES

1. Knowledge of inorganic chemistry

2. Knowledge of mathematical analysis and algebra

3. Knowledge of physics

4. Knowledge of physical chemistry

SUBJECT OBJECTIVES

C1 Basic terminology of analytical chemistry

C2 Knowledge of measurement techniques

C3 Obtaining knowledge about instrumentation

C4 Making the right choice of measurement method

77



PEK_W01 - knows the basic concepts of analytical chemistry,

PEK_W02 - can choose the appropriate analytical technique,

PEK_W03 - can assess the scope of applicability of the measurement method,

PEK_W04 - has a basic knowledge of optics, spectroscopy and electrochemistry,

PEK_W05 - can describe and quantify physical and chemical processes,

Relating to skills:

PEK_U01 - can practically use measuring instruments,

PEK_U02 - can prepare standard solutions within the required range of concentrations,

PEK_U03 - can independently perform the measurement,

PEK_U04 - can perform calculations, graphs and analyze errors

PEK_U05 - can make a report of the performed experiments,

PROGRAMME CONTENT


Lec 1 Introduction. Requirements for completion of the course.

Signal and noise. Statistical methods in analytical chemistry: errors,

confidence intervals, variance, regression and correlation.

2

Lec 2 Introduction to measurement. Measuring equipment. Develop data:

record the results, charts and tables. Computer control.

Accuracy and review of measurement methods: the standard curve

method, the method of standard addition, the method using additives

extrapolation, the method of benchmarking, the method of internal

standard review of analytical techniques.

2

Lec 3 Fundamentals of optics and optical components. Basic optical laws.

Geometrical optics and wave. Optical instruments: light sources,

detectors, polarizers, mirrors, lenses. The construction of basic

optical devices: an interferometer, polarimeter, refractometer.

2

Lec 4 Optical methods. The principle of optical measurements. Interaction

of light with matter. Influence of the type and concentration of the

material on the state of the light wave. Interpretation of the

measurement results.

2

Lec 5 Absorptiometry and luminescence. Spectroscopy applications. Types

and construction of spectrophotometers. Methods of absorption and

emission. Flame photometry.

Introduction to electrochemistry. Model band. Ionic conductivity.

Electrolytes.

2

Lec 6 Electroanalysis (polarography, potentiometry, amperometry,

conductometry). Electrolysis. Faraday's Law. Electrochemical cells.

Construction of electrochemical setups. Description of measurement

techniques. Interpretation of results.

Introduction to some other analytical methods.

2

Lec 7 The repetition of the material and the first colloquium 2

Lec 8 Second colloquium 1

Total hours 15

78


Lab 1 Health and Safety Training. How to keep and pass the laboratory.

Knowing the distribution of posts in the IA lab. 4

Lab 2 Potentiometry, 4 Lab 3 Amperometry, 4 Lab 4 Conductometry, 4

Lab 5 Voltametry 4

Lab 6 Flame photometry, 4

Lab 7 Absorptiometry, 4

Lab 8 Refractometry, 4

Lab 9 Polarimetry, 4

Lab 10 Interferometry 4

Lab 11 Photometric titration, 4

Lab 12 Luminescence, 4

Lab 13 Trace analysis, 4

Lab 14 Repetition of material 4

Lab 15 Repetition of material knowledge test and completion of a course 4

Total hours 60

TEACHING TOOLS USED

N1 Lecture with a multimedia presentation

N2 Execution experience

N3 A report


Evaluation


semester),


semester end)

Educational effect


achievement

C (Lec) PEK_W01 –

PEK_W05

final test

F1 (Lab) PEK_W01 –

PEK_W05

small exam

F2 (Lab) PEK_U01 –

PEK_U05

laboratory report

C (Lab)) = (F1 + F2)/2

79


PRIMARY LITERATURE:

1. Cygański A., Metody spektroskopowe w chemii analitycznej, WNT 2002, Warszawa.

2. Cygański A., Metody elektroanalityczne, WNT 1995, Warszawa

3. Minczewski J., Marczenko Z., Chemia analityczna, tom 3, Analiza instrumentalna, PWN

1985, Warszawa

4. Szczepaniak W., Metody instrumentalne w analizie chemicznej, PWN 2004, Warszawa


1. Szmal Z., Lipiec T., Chemia analityczna z elementami analizy instrumentalnej, PZWL

1997, Warszawa

SUBJECT SUPERVISOR


dr hab. inż. Stanisław Bartkiewicz, [email protected]

80


FOR SUBJECT

Instrumental Analysis


Chemistry

Subject

educational

effect





Subject



number***

(knowledge)

PEK_W01

S2Ach1_W08, S2Ach2_W07,

S2Ach3_W09

C1 Lec1 N1

PEK_W02 S2Ach1_W08, S2Ach2_W07,

S2Ach3_W09 C2, C3 Lec1-Lec7 N1


S2Ach3_W09 C4 Lec1, Lec2 N1


S2Ach3_W09 C4 Lec3-Wy6 N1


S2Ach3_W09 C3 Lec1-Wy8 N1

(skills)

PEK_U01

S2Ach1_U09, S2Ach2_U06,

S2Ach3_U07 C3 Lab1 – Lab15 N2, N3

PEK_U02 S2Ach1_U09, S2Ach2_U06,









*** - from table above(competences)

81

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish Instrumentalna analiza leków

Name in English Instrumental drug analysis Main field of study (if applicable)

Chemistry

Specialization (if applicable) Medicinal chemistry, Bioinformatics

Level and form of studies: 1st/ 2nd* level, full-time / part-time*

Kind of subject obligatory / optional / university-wide*


Group of courses YES / NO* *delete as applicable


Number of hours of







with grade


(X) final course








COMPETENCES

11. Has a general knowledge about fundamentals in analytical chemistry

SUBJECT OBJECTIVES

C1 Getting to know experimental techniques and procedures of the sample preparation

used in basic instrumental analytical techniques of drug analysis

C2 Acquainting with theoretical basis of working and mesurements of instruments for

the drug analysis

C3 Getting to know with methods of the sampling and the sample preparation of

pharmaceuticals

C4 Obtaining basic skills related to the use of instruments in drug nalysis

C5 Learning how to perform basic calculations necessary to develop results of analyzes

carried out

82



The person who passed the course

PEK_W01 – knows basic concepts related to the drug analysis, stages of the analytical

procedure, i.e., the preparation of samples and the analysis of active substances

PEK_W02 – knows parameters characterizing instrumental methods of the analysis and why

these methods should be validated

PEK_W03 – knows types of spectroscopic methods of the drug analysis, including atomic

and molecular spectrometries

PEK_W04 – knows instrumental methods applied for the assessment of the structure of

studied compounds, i.e., IR, NMR, XRD

PEK_W05 – knows methods applied for the chromatographic and electrophoretic

separations of compounds

PEK_W06 – knows basic methods of the sample preparation in the drug analysis

Relating to skills:


PEK_U01 – can select and apply the most suitable for the type of the sample and the aim of

the analysis the method of the sampling and the sample preparation of

pharmaceuticals

PEK_U02 – can choose the right for the type of the sample and the aim of the analysis the

measurement method

PEK_U03 – can perform the analysis using apparatus suitable for the type of the analysis

and the determined component

PEK_U04 – can perform calculations related to results of analyzes and determinations,

assess the accuracy of results and verify measurement errors

PROGRAMME CONTENT


Lec 1 Introduction to the drug analysis - basic definitions and concepts,

steps of the sample preparation and the analysis of active substances 2

Lec 2 Parameters characterizing instrumental methods of the analysis, the

validation of methods and procedures 2

Lec 3 Introduction to spectroscopic methods used in the drug analysis 2

Lec 4 Review of atomic and molecular spectroscopic methods of the

analysis of pharmaceuticals 2

Lec 5 Overview of methods used in the drug analysis to determine the

chemical structure of substances 2

Lec 6 Overview of chromatographic and electrophoretic separation

methods used in the drug analysis 2

Lec 7 Techniques used for the preparation of pharmaceuticals to

concentrate, separate and isolate substances 3

Total hours 15

83


Lab 1 Conditions for the completion of the course. The safety in the

laboratory 2

Lab 2 Testing properties of the formulation containing magnesium lactate 4

Lab 3 The determination of the active ingredients of the formulation 4

Lab 4 The determination of main metallic components of the formulation

and impurities 4

Lab 5 The statistical evaluation of results 4

Lab 6 The application of the powder X-ray diffraction analysis of

pharmacruticals 4

Lab 7 The determination of trace elements in Polish herbal

pharmaceuticals (1) – the preparation of samples 4

Lab 8 The determination of trace elements in Polish herbal

pharmaceuticals (2) the use of atomic absorption spectrometry 4

Total hours 30

TEACHING TOOLS USED

N1 Informative lectures

N2 Implementation of experiments

N3 Preparation of reports

N4 Consultations


Evaluation


semester),


semester end)

Educational effect


achievement

C (lecture) PEK_W01 –

PEK_W06

Final examination

C (laboratory) PEK_U01 –

PEK_U04

Arithmetic mean of all marks for reports

with results of all analyses and experiments

made

84


PRIMARY LITERATURE:

[1]. A. Kar, Pharmaceutical Drug Analysis, New Age Internation (P) Ltd. Publishers, New

Delhi, 2005

[2] D. G. Watson, Pharmaceutical Analysis, Churchill Livingstone, Edinburgh, 1999

[3] S. AHUJA, Stephen SCYPINSKI, Handbook of Modern Pharmaceutical Analysis,

Academic Press, San Diego, 2000


[1] R. Kellner, J.-M. Mermet, M. Otto, H. M. Widmer (editors), Analytical Chemistry,

Wiley-VCH, Weinheim, 1998

[2] Skoog D.A., West D.M., Holler F.J. (1996). Fundamentals of Analytical Chemistry,

Saunders College Publishing

[3] WHO (1991). Guidelines for assessment of herbal medicines. Publications of the World

Health Organisation, Geneva

SUBJECT SUPERVISOR


Dr hab. inż. Paweł Pohl, Prof. PWr, [email protected]


FOR SUBJECT

Instrumental drug analysis


Biotechnology, Chemistry

Subject

educational

effect





Subject



number***

(knowledge)

PEK_W01 –

PEK_W06

S2Ach4_W03, S2bt5_W06 C1, C2 Lec 1 – Lec 7 N1

(skills)

PEK_U01 S2Ach4_U03, S2bt5_U09 C3 – C5 Lab 2 – Lab 8 N2, N3, N4

* - enter symbols for main-field-of-study/specialization educational effects



85

Zał. nr 4 do ZW

Faculty of Chemistry

Course card

Course name in Polish Wstęp do statystyki praktycznej

Name in English Introduction to the practice of statistics Major (if applicable) Biotechnology

Specialization (if applicable): Bioinformatics

Level and form of studies: II level*, full-time / part time*

Kind of course: obligatory/ optional / university-wide*

Course code MAP003047

Group of courses YES / NO*


Number of hours of


University (ZZU)

15 15



60 30

Form of crediting Examinati

on /

crediting

with

grade*

Examination

/ crediting

with grade*

Examination /

crediting with

grade*

Examination

/ crediting

with grade*

Examination

/ crediting

with grade*


(X) final course

Number of ECTS points 2 1

including number of

ECTS points for practical

(P) classes

1

including number of

ECTS points for direct

teacher-student contact

(BK) classes

0,5 0,5

*delete if not applicable


1. Student has understands and applies basic notions of mathematical analysis..

2. Student knows probability theoryas required on matura at basic level.

COURSE OBJECTIVES C1 Learn descriptive statistics and visualization of data.

C2 Learn basic notions of probability and their applications in mathematical 85odeling.

C3 Learn to build statistical models and formulate necessary assumptions.

C4 Learn to select procedures to given statistical analyses.

*delete if not applicable

86

Course educational effects

Concerning knowledge, student knows:

PEK_W01 basic graphical methods of presenting data and procedures leading to them

PEK_W02 how to model random phenomena and apply probability models

PEK_W03 basic descriptive statistics and their numerical procedures

PEK_W04 methods of estimation for basic parametric models

PEK_W05 tests of significance for parameters in parametric models and basic non-

parametric models

Concerning skills, student can:

PEK_U01 apply basic graphical methods to present experimental data

PEK_U02 perform basic calculations related to probability models

PEK_U03 select and calculate descriptive statistics to experimental data and calculate them

PEK_U04 select statistical test to analyze typical experimental data

Concerning social skills, student:

PEK_K01 is able to find knowledge in the bibliography of the course

PEK_K02 is able to use software for basic analysis of statistical models

PEK_K03 understands the need for systematic own work to master the course’s material

COURSE CONTENT

Form of classes – lecture Number

of hours

Wy1

Visual and numerical description of data. Variables. Frequency

histogram. Typical statistics: mean, median, quantiles, variance,

standard deviation. Linear transformations of variables.

Densities. Skewness. Normal distribution: probabilities and quantiles.

Standardization. Normal probability plot.

2

Wy2

Explanatory and response variables. Scatterplot. Linear regression.

Correlation. Residuals. Causality.

Experimental and observational studies. Controls. Sampling and

randomization. Random numbers. Block designs. Statistical

significance. Parameters and statistics. Sampling distributions. Bias

and variability.

2

Wy3

Binomial distribution in sampling: probabilities and parameters.

Means and sums in the binomial setting. Central limit theorem for the

binomial distribution.

Sampling distribution of the sample mean: their expectation and

standard deviation. Independence. Central limit theorem for the sample

mean.

2

Wy4

Tests of significance. Tests for the mean based on the central limit

theorem. Hypotheses, P-value, significance level, directional and non-

directional tests. Statistical significance and practical importance.

Bonferroni correction.

2

Wy5

Significance tests and confidence intervals based on Student

distribution. One-sample and two-samples tests.

Significance tests and confidence intervals for proportions. Planning

the size of the experiment.

2

87

Wy6

Contingency tables. Joints, marginal and conditional distributions.

Chi-square test for independence. Simpson paradox.

Statistical models for linear regression. Confidence intervals for

parameters and prediction in regression.

2

Wy7 Analysis of variance. Structure of data. Hypotheses and test statistics.

Pairwise comparisons. 2

Wy8 Final 1

Total hours 15

Form of classes – recitation Number

of hours

Ćw1 Describing distributions. Calculating basic statistics. Calculations for

the normal distributions. 2

Ćw2 Planing and performing statistical studies. 2 Ćw3 Calculating sampling distributions and their parameters. Approximate

normal calculations. 2

Ćw4 Formulating hypotheses, calculating P-values, performing normal

tests. 2

Ćw5 Midterm 1

Ćw6 T-tests and confidence intervals for means. Tests and intervals for

proportions. Plan sufficient sample size. 2

Ćw7 Test for independence in contingency tables. 2

Ćw8 Perform statistical analysis of linear regression and one-factor

analysis of variance. 2

Total hours 15

TEACHING TOOLS USED

N1. Lecture – traditional method

N2. Classes – traditional method (exercises solving and discussion)

N3. Office hours

N4. Student’s own work – preparation for the classes

EVALUATION OFCOURSE’S EDUCATIONAL EFFECTS ACHIEVEMENT

Evaluation (F –

forming (during

semester), P –

concluding (at

semester end)

Educational effect

number Way of evaluating educational effect achievement

P-Wy PEK_W01-PEK_W05

PEK_K01-PEK_K03

test

P-Ćw PEK_U01-PEK_U04

PEK_K01-PEK_K03 oral presentations, quizzes, test

P=1/2*Wy+1/2Ćw

88


PRIMARY LITERATURE:

1. J. Koronacki, J. Mielniczuk, Statystyka dla studentów kierunków technicznych i

przyrodniczych, WNT, Warszawa 2004.

2. L. Gajek, M. Kałuszka, Wnioskowanie statystyczne. Modele i metody. WNT,

Warszawa 2004.

3. J. Greń, Statystyka matematyczna. Modele i zadania, PWN, Warszawa 1976.

4. W. Kordecki, Rachunek prawdopodobieństwa i statystyka matematyczna. Definicje,

twierdzenia, wzory, Oficyna Wydawnicza GiS, Wrocław 2002.

5. H. Jasiulewicz, W. Kordecki, Rachunek prawdopodobieństwa i statystyka

matematyczna. Przykłady i zadania. GiS, Wrocław 2001.


[1] T. Inglot, T. Ledwina, Z. Ławniczak, Materiały do ćwiczeń z rachunku

prawdopodobieństwa i statystyki matematycznej, Wydawnictwo Politechniki

Wrocławskiej, Wrocław 1984.

[2] W. Klonecki, Statystyka matematyczna, PWN, Warszawa 1999.

[3] W. Krysicki, J. Bartos, W. Dyczka, K. Królikowska, M. Wasilewski, Rachunek

prawdopodobieństwa i statystyka matematyczna w zadaniach, Cz. I-II, PWN,

Warszawa 2007.

[4] D. Moore, G. McCabe, Introduction to the Practice of Statistics, ed. IV, Freeman,

2003.


Prof. dr hab. Krzysztof Bogdan ([email protected]) Komisja programowa Instytutu Matematyki i Informatyki

89

MATRIX OF CONNECTIONS BETWEEN EDUCATIONAL EFFECTS FOR SUBJECT

Introduction to the practice of statistics

AND EDUCATIONAL EFFECTS FOR MAIN FIELD OF STUDY ……

AND SPECIALIZATION …..

Subject

educational

effect

Correlation between subject educational

effect and educational effects defined for

main field of study and specialization (if

applicable)**

Subject



number***

PEK_W01

(knowledge) C1, C2 Wy1 1,3,4

PEK_W02 C1-C4 Wy1-Wy8 1,3,4

PEK_W03 C1 Wy4-Wy8 1,3,4

PEK_W04 C1, C3, C4 Wy4, Wy5 1,3,4

PEK_W05 C1, C3, C4 Wy6-Wy8 1,3,4

PEK_U01

(skills) C1 Ćw1, Ćw8 1,2,3,4

PEK_U02 C1-C4 Ćw1-Ćw4,

Ćw8

1,2,3,4

PEK_U03 C1 Ćw5, Ćw8 1,2,3,4

PEK_U04 C1, C3, C4 Ćw6-Ćw8 1,2,3,4

PEK_K01 (competences)

C1-C4 Wy1-Wy8

Ćw1-Ćw8

1,2,3,4

PEK_K02 C1-C4 Wy1-Wy8

Ćw1-Ćw8

1,2,3,4

PEK_K03

C1-C4 Wy1-Wy8

Ćw1-Ćw8

1,2,3,4



90

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish Naturalne Produkty Medyczne

Name in English Medicinal Natural Products Main field of study (if applicable) Chemistry, Biotechnology

Specialization (if applicable) Medicinal chemistry, Pharmaceutical

biotechnology






Number of hours of






with grade


(X) final course








COMPETENCES

12. General knowledge of organic chemistry

13.

SUBJECT OBJECTIVES

C1 General knowledge of herbal primary metabolic buildings blocks

C2 General knowledge of herbal secondary metabolic buildings blocks

C3 Knowledge of biological active herbal compounds

C4 Knowledge concerned the application of biological active compounds

C5 Knowledge of english terminology of natural medicinal compounds

C6 Knowledge of isolation methods and identification techniques of natural compounds

91



PEK_W01 – knowledge of basic definitions of phitochemistry, chemistry of natural products

PEK_W02 – classification of herbal building blocks

PEK_W03 – basic knowledge of herbal metabolic pathways

PEK_W04 – basic knowledge of coumarins

PEK_W05 - basic knowledge of flavonoids and stilbenes

PEK_W06 - basic knowledge of terpenoids and steroids

PEK_W07 - basic knowledge of alkaloids and glycosides

PEK_W08 - basic knowledge of natural anticancer compounds

PEK_W09 - basic knowledge of english terminology of medicinal natural products

.

Relating to skills:

PEK_U01 – knowledge of basic rules of work in laboratory of organic chemistry

PEK_U02 – practical knowledge of methods of isolation of natural product from herbal

material

PEK_U03 – practical knowledge of methods of distillation and extraction in processes of

isolation of natural product

PEK_U04 – practical knowledge of methods of chromatography in identification and

purification of natural product

PEK_U05 – practical knowledge of determining of acidic and ester number

Relating to social competences: PEK_K01

PEK_K02

…

PROGRAMME CONTENT


Lec 1 Development of phytochemistry and chemistry of natural

products. The lecture concerns the history of using of biological

active substances in curing different types of diseases.

1h/

Lec 2-

3

Herbal biological active compounds. Interest has revived recently

in the investigation of medicinal plants to identify novel active

phytochemicals that might lead to drug development. Nature has

generated such substances for millennia — before modern synthetic

chemistry. Because these substances arise from a more or less hostile

environment, the percentage of biologically active natural substances

is relatively high in comparison with substances from artificial

sources. Currently more than 50% of drugs in clinical use have a

natural-product origin.

2h

Lec 4-

5

Herbal building blocks. Metabolites are compounds synthesized by

plants for both essential functions, such as growth and development

(primary metabolites), and specific functions, such as pollinator

attraction or defense against herbivory (secondary metabolites).

Secondary metabolites are often colored, fragrant, or flavorful

compounds, and they typically mediate the interaction of plants with

2h

92

other organisms. Such interactions include those of plant-pollinator,

plant-pathogen, and plant-herbivore. Because of the importance of

these and other primary pathways in enabling a plant to synthesize,

assimilate, and degrade organic compounds, primary metabolites are

essential.

Lec 6-

7

Coumarins. They belong to the benzopyrones family and possess a

wide range of pharmaceutical applications including cytoprotective

and modulatory functions, which may be translated into therapeutic

potential for multiple diseases. Several natural and synthetic

coumarins and derivatives, such as coumarin glycosides, possess

potent biological activities. Coumarin derivatives are found in

antibiotic, antimitotic, immunomodulating, antiviral, anticancer, anti-

inflammatory, anticoagulant, antifungal, antioxidant, and cytotoxic

agents, as well as some biological assays.

2h

Lec 8-

9

Flavonoids and stilbenes. Polyphenolic compounds that are

ubiquitous in nature and are categorized, according to chemical

structure, into flavonols, flavones, flavanones, isoflavones, catechins,

anthocyanidins and chalcones. Over 4,000 flavonoids have been

identified, many of which occur in fruits, vegetables and beverages

(tea, coffee, beer, wine and fruit drinks). The flavonoids have

aroused considerable interest recently because of their potential

beneficial effects on human health-they have been reported to have

antiviral, anti-allergic, antiplatelet, anti-inflammatory, antitumor and

antioxidant activities. Stilbenes are a small family of plant secondary

metabolites derived from the phenylpropanoid pathway, and

produced in a number of unrelated plant species. These compounds

have numerous implications in plant disease resistance and human

health.

2h

Lec

10-13

Terpenoids and steroids. Terpenoids or isoprenoids, a subclass of

the prenyllipids (terpenes, prenylquinones, and sterols), represent the

oldest group of small molecular products synthesized by plants and

are probably the most widespread group of natural products.

Terpenoids can be described as modified terpenes, where methyl

groups are moved or removed, or oxygen atoms added. They are

universally present in small amounts in living organisms, where they

play numerous vital roles in plant physiology as well as important

functions in all cellular membranes. A steroid is a type of organic

compound that contains a characteristic arrangement of four

cycloalkane rings that are joined to each other. Examples of steroids

include the dietary fat cholesterol, the sex hormones estradiol and

testosterone and the anti-inflammatory drug dexamethasone.

4h

Lec

14-15

Alcaloids and glycosides. Alkaloids are compounds containing

nitrogen in a heterocyclic ring that are common to about 15 to 20%

of all vascular plants. They are synthesized by plants from amino

acids. Alkaloids are subclassified on the basis of the chemical type of

their nitrogen containing ring. Alkaloids are formed as metabolic by-

products. However, their characteristic bitter taste and accompanying

toxicity generally help to repel insects and herbivores. Glycosides

play numerous important roles in living organisms. Many plants store

2h

93

chemicals in the form of inactive glycosides. These can be activated

by enzyme hydrolysis, which causes the sugar part to be broken off,

making the chemical available for use. Many such plant glycosides

are used as medications. In animals and humans, poisons are often

bound to sugar molecules as part of their elimination from the body.

Total hours 15h


Lab 1 Organizatinal class and lab safety rules 2

Lab

2-3 Alkaloids of pepper. Isolation of piperidine from pepper. TLC as

identification method. 4

Lab

4-5 Herbal fats – isolation of trimyristin from nutmeg. Determination of ester

number. 4

Lab

6-7 Hydrolysis of trimyristin. Determination of acidic number. I Test

4

Lab

8-9 Steroids – cholesterol of hen egg.

4

Lab

10-11

Licopene and beta-carotene - isolation of products of tomato or carrot.

Column chromatography. 4

Lab

12-13

Triterpenes. Isolation of betulin from birch bark. Continuous extraction. 4

Lab

14-15

Isolation of eugenol of gloves. II Test. 4

Total hours 30

TEACHING TOOLS USED

N1 Lecture with multimedia presentation

N2 Laboratory – experimental work

N3 Laboratory - report


Evaluation


semester),


semester end)

Educational effect


achievement

F1 (lecture) PEK_W01 –

PEK_W09

exam

F2 (laboratory) PEK_U01 –

PEK_U03

Test I (max 8 points)


PEK_U05

Test II (max 8 points)


PEK_U05

Correctness of experimental work and

preparation of reports (max 8 points)

C (laboratory) = 3.0 when (F2 + F3 + F4) = 16.0 – 17.5 pkt.

3.5 when (F2 + F3 + F4) = 18.0 – 19.0 pkt.

4.0 when (F2 + F3 + F4) = 19.5 – 20.5 pkt.

4.5 when (F2 + F3 + F4) = 21.0 – 22.5 pkt.

94

5.0 when (F2 + F3 + F4) = 22.5 – 23.5 pkt.

5.5 when (F2 + F3 + F4) = 24.0 pkt.


PRIMARY LITERATURE:

[18] P.M. Dewick, Medicinal natural products, Wiley 2009

[19] J. Sołoducho, J. Cabaj, Medicinal natural products – lecture, PRINTPAP

Łódź, 2011

[20] J. Sołoducho, J. Cabaj, Medicinal natural products – laboratory, elektronic

materials


[21]

[22]

[23]

SUBJECT SUPERVISOR


Prof. dr hab. Jadwiga Sołoducho, [email protected]


FOR SUBJECT

Medicinal Natural Products


Chemistry/Biotechnology Subject

educational

effect





Subject



number***

(knowledge)

PEK_W01 S2Ach4_W02 C3-C5 L1-L2 N1

PEK_W02 S2Ach4_W02 C1-C2, C5 L 3-L4 N1

PEK_W03 S2Ach4_W02 C1-C2, C5 L5 N1

PEK_W04 S2Ach4_W02 C3, C5 L6–L7 N1

PEK_W05 S2Ach4_W02 C3, C5 L8-L9 N1

PEK_W06 S2Ach4_W02 C3, C5 L10-L13 N1

PEK_W07 S2Ach4_W02 C3, C5 L14-L15 N1

PEK_W08 S2Ach4_W02 C4, C5 L2 N1

PEK_W09 S2Ach4_W02 C5 L1-L15 N1

(skills)

PEK_U01 S2Ach4_W02 C5, C6 Lab1 N2, N3

PEK_U02 S2Ach4_W02 C5, C6 Lab2-15 N2, N3

PEK_U03 S2Ach4_W02 C5, C6 Lab2-15 N2, N3

PEK_U04 S2Ach4_W02 C5, C6 Lab2-3; Lab10-

11 N2, N3

95

PEK_U05 S2Ach4_W02 C5, C6 Lab4-7

(competences)

PEK_K01 S2Ach4_W02 C5 L1-L15 N1

PEK_K02 S2Ach4_U02 C5-C6 Lab1 N2, N3

PEK_K03 S2Ach4_U02 C5-C6 Lab2-Lab15 N2, N3

… S2Ach4_U02 C5-C6 Lab2-Lab15 N2, N3



96

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish:

Name in English: Metal matrix composites and powder metallurgy Main field of study (if applicable): Chemistry



level, full-time





Number of hours of


University (ZZU) 15




with grade


(X) final course





contact (BK) classes 0.5




SUBJECT OBJECTIVES

C1 Familiarization students with basics of metal matrix composites

C2 Acquainting students with properties, production and application of metal matrix

composites

C3 Familiarization of students with methods of powder metallurgy and consolidation of

powders

C4 Familiarization of students with powder metallurgy of refractory and reactive metals,

supper alloys and dispersion-strengthened materials

97



PEK_W01 – knows basic information concerning metal matrix composites,

PEK_W02 – knows properties, methods of production and applications of metal matrix

composites,

PEK_W03 – has a general knowledge concerning powder metallurgy

PEK_W04 – knows technological aspects of powder metallurgy of refractory and reactive

metals, supper alloys and dispersion-strengthened materials

PROGRAMME CONTENT


Lec1 Basics of metal matrix composites 2

Lec2 Particles, fibers and short fibers for the reinforcement of metal

materials 2

Lec3 Aluminum matrix composites in combustion engines 2

Lec4 Production of composites or bonding of material by thermal

coating processes 2

Lec5 Mechanical behavior and fatigue properties of metal matrix

composites 2

Lec6 Commercial methods for the production of metal powders 2

Lec7 Consolidation of metal powders 1

Lec8 Powder Metallurgy of Refractory and Reactive Metals, Powder

Metallurgy of Supper Alloys, Dispersion-Strengthened Materials 2

Total hours 15

TEACHING TOOLS USED



Evaluation


semester),


semester end)


achievement


98


PRIMARY LITERATURE:

[1]. K.U. Kainer (Ed.), Metal Matrix Composites, Willey-VCH 2003

[2]. P.C. Angelo, R. Subramanian, Powder Metallurgy: Science, Technology and

Applications, PHI Leaming Private Limited, New Delhi 2008



SUBJECT SUPERVISOR




FOR SUBJECT

Metal matrix composites and powder metallurgy


Chemistry

Subject





Subject



number***

(knowledge)







99

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish: Metalurgia metali niezelaznych

Name in English: Metallurgy of non-ferrous metals Main field of study (if applicable): Chemistry



level, full-time





Number of hours of


University (ZZU) 30




with grade


(X) final course









SUBJECT OBJECTIVES

C1 Familiarization students with sources of metals and metals application

C2 Acquainting students with thermochemistry and its significance in metallurgy

C3 Familiarization students with unit processes in metalurgy and alloying components

for improvement of alloys properties

C4 Familiarization students with technology Cu, Al, Zn, Pb and U

C5 Acquainting students with selected alloys technologies

C6 Familiarization students with today and future technologies using nonferrous metals

incl. “critical” metals.

100



PEK_W01 – knows sources of metals and has knowledge about significance of metals in

modern technologies,

PEK_W02 – knows basic termochemistry used in metallurgy,

PEK_W03 – knows unit processes used in metallrgy, knows role of alloying components in

improvement of alloys properties,

PEK_W04 – knows technological methodsthat are used in metallurgy of Cu, Al, Zn, Pb and

U,

PEK_W05 – knows technologies of selected alloys production,

PEK_W06 – has basic knowledge concerning today and future technologies based on

nonferrous and “critical” metals

PROGRAMME CONTENT


Lec1 Metals as materials – introduction 2

Lec2 Ores mining and metallurgy processes 2

Lec3 Thermochemistry, thermodynamic functions, equilibrium 2

Lec4 Unit processes in metallurgy - overview 2

Lec5 Role of alloying components for improvement of alloys properties 2

Lec6 Chemical aspects of Cu, Al, Zn, Pb metallurgy 2

Lec7 Re winning from copper industry wastes in KGHM 4

Lec8 Metal separation by gaseous transport processes 2

Lec9 Metallurgy of uranium 2

Lec10 Cu – based alloys, Ni – based alloys, Ti – based alloys, Al – based

alloys, Superalloys and refractory alloys 2

Lec11 Selected metal & alloys technologies: powder metallurgy, metal

glasses 2

Lec12 Composite materials containing metals, “Critical” metals in modern

technologies 2

Lec13 Metals world market: foresight until 2020, Environmental issues incl.

metal recycling 4

Total hours 30

TEACHING TOOLS USED



Evaluation


semester),



achievement

101

semester end)



PRIMARY LITERATURE:

[1]. L. Coudurier, D.W. Hopkins, I. Wilkomirsky, Fundamentals of metallurgical processes,

Pergamon Press, 1978

[2]. J. Antrekowitsch, Metallurgy I / Metallhuttenkunde I”, Univ. Leoben (Austria), 2002

[3]. C.K. Gupta, Chemical metallurgy. Principles and Practice, Wiley – VCH, 2003

[4]. Fathi Habashi, Principles of Extractive Metallurgy. Volume 3: Pyrometallurgy, second

ed., 1993, Gordon and Breach Science Publishers.

[5]. Fathi Habashi, Textbook of Pyrometallurgy, Quebec City, Laval Univ., 2002.


[1]. O. Kubaschewski, C.B. Alcock & P.J. Spencer, Materials Thermochemistry, 6th edition.

Pergamon, 1993.

[2]. N. Sano, W-K. Lu, P.V. Riboud and M. Maeda (eds.), Advanced physical chemistry for

process metallurgy, Academic Press, 1997.

SUBJECT SUPERVISOR




FOR SUBJECT

Metallurgy of non-ferrous metals


Chemistry

Subject





Subject



number***

(knowledge)

PEK_W01

Optional

C1 Lec1-Lec2 N1

PEK_W02 C2 Lec3 N1



PEK_W05 C5 Lec10 N1




102

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SUBJECT CARD

Name in Polish Metale a środowisko

Name in English Metals and Environment Main field of study (if applicable) chemistry



Kind of subject Optional




Number of hours of


University (ZZU) 30




with grade


(X) final course








COMPETENCES

14. Knowledge of inorganic chemistry at the 1st level

SUBJECT OBJECTIVES

C1 Introducing students to the natural and disturbed by humans migrations of metals in

nature

C2 Provide basic knowledge of the geochemistry of metallic elements

C3 Education ecological sensitivity to the need to minimize the anthropogenic sources

of metals in the environment

103



PEK_W01 – student has a basic knowledge of the distribution and migration of elements

biologically and ecologically important

PEK_W02 – student knows the impact of trace elements on the wildlife

PEK_W03 – student learned new technology of extracting metals (bio- and phytomining)

PEK_W04 – student is able to explain the relationship between living conditions in water

bodies and the redox potential and pH

PEK_W05 – student knows the principles of sustainable development and the resulting

demands on manufacturing processes

PEK_W06 – student has knowledge of the ecological consequences of recycling of materials

PROGRAMME CONTENT


Lec 1 Origin of the elements. Internal structure of the Earth.

Geochemical cycles. 2

Lec 2 Chemistry of aquatic ecosystems. Redox processes, E-pH

diagrams. 2

Lec 3 Lithosphere, atmosphere. Abundance of metals in the Earth's crust.

Soil geochemical factors. 2

Lec 4 Metals in the environment. Metal toxicity. 2

Lec 5 Iron: geochemical cycle, iron in the industry, corrosion. 2

Lec 6 Geochemical characteristics and ecology of the elements: Li, K,

Na, Be, Mg, Ca, Al, Sb, Se. 2

Lec 7 Geochemical characteristics and ecology of the elements: Li, K,

Na, Be, Mg, Ca, Al, Sb, Se. 2

Lec 8 Geochemical characteristics and ecology of the elements: Hg, Pb,

As, Cd. 2

Lec 9 Recycling - recovery of metals from waste industrial products. 2

Lec 10 Radioactive elements. Environmental aspects of the use of nuclear

energy. 2

Lec 12 Soil and atmosphere - metallic contaminants, remediation. 2

Lec 12 Hydro- and biohydrometallurgy. The use of organisms in the

extraction of metals – bio- and phytomining. 2

Lec 13 Metals and the principle of sustainable development. 2

Lec 14 Metallic contaminants in selected ecosystems (Baltic Sea, North

Sea, the sea basins). 2

Lec 15 Students presentations. 2

Total hours 30

TEACHING TOOLS USED

N1 lecture and multimedia presentation

104


Evaluation


semester),


semester end)

Educational effect


achievement

C PEK_W01 –

PEK_W14

Presentation presented in electronic form

(3.0 - 4.0) or an oral presentation (3.0 - 5.5)


PRIMARY LITERATURE:

[21] P. O’Neill – ENVIRONMENTAL CHEMISTRY, LONDON : CHAPMAN AND

HALL, 1993

[22] B. J. Alloway, D. C. Ayres – CHEMICAL PRINCIPLES OF ENVIRONMENTAL

POLLUTION, LONDON : BLACKIE ACADEMIC AND PROFFESIONAL, 1994

[23] Z. M. Migaszewski, A. Gałuszka – PODSTAWY GEOCHEMII ŚRODOWISKA,

WNT 2007


[24] A. Kabata-Pendias - TRACE ELEMENTS IN SOILS AND PLANTS, CRC Press,

2011

[25] R. B. Clark – MARINE POLLUTION, Oxford 2001

[26] S. E. Manahan – TOXICOLOGICAL CHEMISTRY AND BIOCHEMISTRY, Taylor

& Francis, 2002

SUBJECT SUPERVISOR


Marek Duczmal, [email protected]


FOR SUBJECT

Metals and Environment


Chemistry

Subject

educational

effect





Subject



number***

(knowledge)

PEK_W01 optional lecture C1, C2

Lec 1, Lec 3,

Lec 5– Lec 8 N1

PEK_W02 C3 Lec 7– Lec 11 N1

105

PEK_W03 C2, C3 Lec 12, Lec 13 N1 PEK_W04 C1 Lec 2, Lec 14 N1 PEK_W05 C3 Lec 4, Lec 3 N1 PEK_W06 C3 Lec 9 N1



106

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SUBJECT CARD

Name in Polish: Procesy mineralurgiczne

Name in English: Mineral processing Main field of study (if applicable): Chemistry



level, full-time





Number of hours of







with grade


(X) final course





student contact (BK) classes 0.5 0.5



COMPETENCES

NONE

SUBJECT OBJECTIVES

C1 Student gets specialized knowledge on ores, minerals, deposits and raw material

C2 Student gets specialized knowledge on methods of minerals benefication

C3 Acquainting students with characteristic phenomena on which the methods of

benefication are based

C4 Student gets knowledge about special equipment used in processes of benefication

C5 Acquainting students with practical functioning of processes of benefication

C6 Acquainting students with material balance during benefication

C7 Acquainting students with knowledge concerning analysis of benefication and

process evaluation

107



PEK_W01 – knows basic concepts and chemical laws in mineral processing,

PEK_W02 – knows selected minerals and methods of their benefication,

PEK_W03 – knows theoretical basis of different benefication methods

PEK_W04 – can correctly specify process of benefication on the basis of literature data,

Relating to skills:

PEK_U01 – knows how to perform practicaly different benefication methods,

PEK_U02 – is capable to conduct basic separation process,

PEK_U03 – can make material balance of separation process,

PEK_U04 – is able to analyze results of separation and evaluate whole process.

PROGRAMME CONTENT


Lec1 Formation of minerals, ores and deposits. Characterization and

analysis of separation processes 2

Lec2 Evaluation of separation processes 2

Lec2 Size reduction. Sizing 2

Lec3 Hydraulic classification and gravity concentration. Magnetic

separation 2

Lec4 Electrostatic separation. Flotation 3

Lec5 Flocculation and Coagulation 2

Lec6 Oil agglomeration 1

Lec7 Test 1

Total hours 15


Lab 1 Introduction, safety rules, SI, calculations, report writing 2

Lab 2 Basic measurement in mineral processing (pH, Eh, density, content, yield,

recovery)

2

Lab 3 Magnetic separation 2

Lab 4 Flotation 2

Lab5 Oil agglomeration 2

Lab6 Screening 2

Lab7 Repetitions 2

Lab8 Final meeting 1

Total hours 15

108

TEACHING TOOLS USED


N2 Theoretical introduction.

N3 Executive instructions for laboratory exercises.

N4 Realization of exercises.


Evaluation


semester),


semester end)


achievement


C2(laboratory) PEK_U01 – PEK_U04 positive evaluation of 6 lab reports


PRIMARY LITERATURE:

[1]. J. Drzymala, Mineral Processing. Foundations of theory and practice of minerallurgy,

WUT, Wroclaw, 2007


[1] E.G. Kelly, D.J. Spottiswood, Introduction to Mineral Processing, Wiley, New York,

1982

[2] B. Wills, T.J. Napier-Munn, Mineral Processing Technology, 2006

SUBJECT SUPERVISOR


Prof. Jan Drzymała; [email protected]


FOR SUBJECT

Mineral processing


Chemistry

109

Subject

educational

effect





Subject



number***

(knowledge)





(skills)


Lab1-Lab6

N2-N4

PEK_U02 S2Ach5_U02 C4-C6 Lab2-Lab6 N2-N4


PEK_U04 S2Ach5_U02 C7 Lab2-Lab6 N3, N4



110

Faculty of Chemistry

SUBJECT CARD

Name in Polish Nowoczesne tendencje zarządzania

Name in English Modern tendencies in management Main field of study (if applicable): ………………………….

Specialization (if applicable): ……………………..


Kind of subject: university-wide

Subject code ZMZ000383

Group of courses NO


Number of hours of organized classes in

University (ZZU) 15

Number of hours of total student workload

(CNPS) 30

Form of crediting crediting with

grade

For group of courses mark (X) final course


including number of ECTS points for practical (P)

classes

including number of ECTS points for direct teacher-




1. None

2.

3. \

SUBJECT OBJECTIVES C1: To provide students with knowledge of the nature, characteristics and directions of

development of management and the challenges facing the modern management.

C2: To familiarize students with selected concepts and methods that are regarded as useful in

the management of the modern enterprise. To present the evidence and barriers to the

implementation of these methods, the basic principles, theirs components, and the advantages

and disadvantages as well.

C3: To provide students with knowledge about the values important for modern enterprises that

are taken into consideration in the management process.



Student:

PEK_W01: has a basic knowledge of management processes: can explain the nature and object

management and identify the basic problems of management.

PEK_W02: has knowledge of the characteristics and directions of the contemporary

management development and of the values relevant to the modern enterprise taken into

consideration in the management process.

PEK_W03: Knows the selected modern management concepts and methods (including TQM,

111

CSR, outsourcing, controlling, benchmarking, CRM, lean management, BPR, process

management, knowledge management, JIT, virtual organization and learning

organization, change management, projects management, time based management,

BSC). Recognizes and understands their nature, objectives, conditions and barriers to

their implementation, their basic components, and the advantages and disadvantages of

their implementation as well.

PROGRAMME CONTENT


Lec 1 Introduction: the nature, object and history of management. 2

Lec 2 Challenges for the contemporary management (globalization and

changes in the business environment, the idea of sustainable

development). Characteristics and trends of contemporary

management (focusing on customers, process approach, network

cooperation, etc.).

2

Lec 3 –

Lec 5

Chosen modern management concepts and methods (CSR,

outsourcing, controlling, benchmarking, CRM, lean management,

BPR, process management, knowledge management, JIT, virtual

organization and learning organization, TQM, value based

management, BSC etc.)

6

Lec 6 –

Lec 7

The values relevant to the modern enterprise taken into account in the

management process (management of cultural diversity, management

of small businesses, family business management, management of

information systems, management of communication in organization,

time management, business ethics etc.)

4

Lec 8 1

Total hours 15


Cl 1

Cl 2

Cl 3

Total hours


Lab 1

Lab 2

Lab 3

Total hours

Form of classes - project Number of hours

Proj 1

Proj 2

Proj 3

Total hours

112


Sem 1

Sem 2

Sem 3

Total hours

TEACHING TOOLS USED

N1. Presentation of knowledge in the form of direct communication (lecture) - audio-visual

media (slides, computer projector)

N2. Lecture materials (synthesis) available in electronic form.

N3. Case studies.


Evaluation (F – forming

(during semester), P –

concluding (at semester

end)

Educational effect

number Way of evaluating educational effect achievement

F1 PEK_W01 –

PEK_W03 Written colloquium

C==100% F1


PRIMARY LITERATURE:

[24] Brilman J.: Nowoczesne koncepcje i metody zarządzania, Polskie Wyd. Ekonomiczne,

Warszawa 2002.

[25] Współczesne metody zarządzania w teorii i praktyce, pod red. M. Hopeja i Z. Krala,

Oficyna Wydawnicza PWr, Wrocław 2011.

[26] Zimniewicz K., Współczesne koncepcje i metody zarządzania, PWE, Warszawa 2009.


[27] Bielski M.: Podstawy teorii organizacji i zarządzania, C. H. Beck, Warszawa 2004.

[28] Drucker P.F., Praktyka zarządzania, Wyd. Nowoczesność, Warszawa 1994.

[29] Podstawy nauki o przedsiębiorstwie, red. J. Lichtarski, Wydawnictwo Akademii

Ekonomicznej we Wrocławiu, Wrocław 2007.

[30] Zarządzanie. Teoria i praktyka, pod red. A.K. Koźmińskiego i W. Piotrowskiego, PWN,

Warszawa 1995.


Anna Zabłocka-Kluczka, PhD. Eng., [email protected]

113

MATRIX OF CORRELATION BETWEEN EDUCATIONAL EFFECTS FOR SUBJECT

Modern tendencies in management

AND EDUCATIONAL EFFECTS FOR MAIN FIELD OF STUDY ………………..

AND SPECIALIZATION ……………………….. Subject educational effect Correlation between subject


effects defined for main field of

study and specialization (if

applicable)**

Subject



number***

PEK_W01 (knowledge)

PEK_W02

PEK_W03

…

PEK_U01 (skills)

PEK_U02

…

PEK_K01 (competences)

PEK_K02

…



114

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish Modelowanie molekularne

Name in English Molecular modeling Main field of study (if applicable) Biotechnology

Specialization (if applicable) Bioinformatics, Medicinal Chemistry






Number of hours of


University (ZZU) 15 30 15


student workload (CNPS) 30 60 15


with grade* crediting

with grade* crediting


(X) final course

Number of ECTS points 2 2 1 including number of ECTS




student contact (BK) classes 2 1 1



COMPETENCES

15. Basic knowledge of atomic and molecular structure concepts

16. Basic knowledge of analytic geometry

17. Basic knowledge of computer science

18. Basic knowledge of organic chemistry

SUBJECT OBJECTIVES

C1 Teaching construction of 3-D molecular models

C2 Teaching elementary quantum chemistry methods

C3 Teaching elementary concepts of the theory of intermolecular interactions

C4 Teaching modeling techniques of molecular aggregates

C5 Teaching modeling chemical reactions

115



PEK_W01 – knowledge of construction of 3-dimensional molecular models and their

transformations

PEK_W02 - knowledge of elementary molecular modeling methods and limits of their

applications.

PEK_W03 - knowledge of major components of intermolecular interaction energy

PEK_W04 - knowledge of modeling drugs and biocatalysts

Relating to skills:

PEK_U01 – ability of construction of 3-D molecular model starting from assumed

hybridization type

PEK_U02 – ability to predict molecular structure and properties

PEK_U03 - ability to predict possibile structures of molecular aggregates

PEK_U04 - ability to analyse protein-ligand interactions

PEK_U05 - ability to model dynamic properties of molecular aggregates

PROGRAMME CONTENT

Form of classes – lecture Number of hours

Wy1

Basic concepts. Interdisciplinary charakter of molecular modeling.

Typical molecular modeling tasks. Molecular structure sources.

Algorithms used in construction of 3-D molecular models with

examples. Hybridization. Coordinate transformations. Basic

concepts of molecular graphics. Visualization techniques.

Literature review.

2

Wy2

Basic concepts of quantum chemistry. Review of quantum

chemistry computational methods. Hueckel Molecular Orbitals and

ab intio methods. Theoretical prediction of physical properties and

structure.

2

Wy3 Construction of molecular models – exercise and test 2

Wy4

Basic concepts of the theory of intermolecular interactions.

Perturbation theory. Characteristics of major components of

intermolecular interaction components.

2

Wy5 Hydrogen bonding. Molecular charge distribution and electrostatic

models. Force fields. 2

Wy6 Predicting properties and structure of molecular aggregates –

exercises and test. 2

Wy7 Modeling interactions In receptors and enzyme active centers. Drug

design techniques. Molecular dynamice. Homology modeling. 2

Wy8 Analysis of enzyme catalytic activity and biocatalyst design. 1

Total hours 15


116

La1 Introduction and lab organization. 2

La2 Molecular structure graphical representations 2

La3 Preparing molecular dynamice simulations 2

La4 Analysis of molecular dynamice trajectories 2

La5 Computational task #1. 2

La6 Z matrix representation of molecular structure - introduction to

Molden program.

2

La7 Theoretical introduction to quantum chemical calculations of

molecular structure.

2

La8 Geometry optimization calculation of molecular properties. 2

La9 Analysis and visualization of results of quantum chemical

calculations. Analysis of normal vibrations.

2

La10 Noncovalent interactions. Structure of aggregates and interaction

energy calculations.

2



La13 Introduction to theoretical methods used in silico docking. 2

La14 Receptor-ligand docking simulations 2

La15 Computational task #4 2

Total hours 30


Se1 Student seminars: protein structure prediction, homology modeling 2

Se2 Student seminars: superimposing molecules, docking, predicting

protonation state

2

Se3 Student seminars: modeling receptors, sensors, molecular switches,

molecular motors

2

Se4 Student seminars: use of genetic algorithms and neural nets in

molecular modeling

2

Se5 Student seminars: drug design techniques 2

Se6 Student seminars: modeling IR, Raman, UV, NMR spectra 2

Se7 Student seminars: modeling chemical Reaction and transition states 2

Se8 Student seminars: biokatalyst design 1

Total hours 15

TEACHING TOOLS USED

N1 Lecture with multimedia presentation

N2 Solving problems

N3 Use of software

N4 Student multimedia presentation

N5 Preparing report


Evaluation


Educational effect


achievement

117

semester),


semester end)

F1 (lecture) PEK_U01 Test #1

F2 (lecture) PEK_U02

PEK_U03

Test #2

C (lecture) = F1 + F2

C (seminar) PEK_W01

PEK_W02

PEK_W03

PEK_W04

Student multimedia presentation

F3 (lab) PEK_U05 Partial report #1

F4 (lab) PEK_U01

PEK_U02

Partial report #2

F5 (lab) PEK_U02

PEK_U03

Partial report #3

F6 (lab) PEK_U04 Partial report #4

C (lab) = F3 + F4 + F5 + F6


PRIMARY LITERATURE:

[27] L. Piela, Quantum Chemistry Ideas, Elsevier, 2010

[28] A.R. Leach, Molecular Modeling:Principles and Applications, 2 wydanie,

Prentice Hall, 2001

[29] H.D. Hotje, Molecular modeling. Basic principles and applications, 3

wydanie, Wiley, 2008

[30] T. Schlick, Molecular modeling and simulation, Springer, 2002.


[31] F. Jensen, Introduction to computational chemistry, Wiley, 2006 (2-nd Ed)

[32] J.M. Goodman, Chemical Applications of Molecular Modeling, RSC, 1999.

[33] J.P. Doucet, J. Weber, Computer-Aided Molecular Design, 1996,Academic

Press, 1996

[34] G.H. Grant, W.G. Richards, Computational chemistry, Oxford Sci. Publ.,

1995

SUBJECT SUPERVISOR


W. Andrzej Sokalski, [email protected]


118


FOR SUBJECT

Molecular modeling


Bioinformatics

Subject

educational

effect





Subject



number***

(knowledge)

PEK_W01

T2A_W02 T2A_W03

X2A_W02 X2A_W03 C1

Wy1,Wy3

Se1, Se2 N1,N2, N4

PEK_W02 T2A_W02 T2A_W03

X2A_W02 X2A_W03 C2

Wy2,Wy6

Se3, Se4 N1,N2, N4


X2A_W02 X2A_W03 C3

Wy4, Wy6

Se5, Se6 N1,N2, N4


X2A_W02 X2A_W03 C4, C5

Wy7, Wy8

Se7,Se8 N1,N4

(skills)

PEK_U01

T2A_U01 T2A_U08 T2A_U11

InzA_U01 C1 La2, La6 N2, N3, N5

PEK_U02 T2A_U01 T2A_U08 T2A_U11

X2A_U03 X2A_U04 InzA_U01 C2

La7, La8, La9,

La11 N2, N3, N5


X2A_U03 X2A_U04 InzA_U01 C3 La10, La12 N3, N5


X2A_U03 X2A_U04 InzA_U01 C4

La13, La14,

La15 N3, N5


X2A_U03 X2A_U04 InzA_U01 C4 La3, La4, La5 N3, N5



119

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish Wieloetapowa Synteza Organiczna

Name in English Multistep Organic Synthesis Main field of study (if applicable) Chemistry





Group of courses NO


Number of hours of


University (ZZU) 30




with grade


(X) final course








COMPETENCES

19. Knowledge and skills at the level of completion of "Fundamentals of Organic

Chemistry - laboratory" course, or equivalent.

SUBJECT OBJECTIVES

C1 Gathering proficiency in the laboratory work using advanced experimental

techniques of organic synthesis.

C2 Abilities to employ various transformation methods in a multi-step synthesis.

C3 Planning and execution of a complex synthetic sequence based on the literature data.

120


Relating to skills:


PEK_U01 - is able to perform multistep synthesis of an organic compound, select and

assemble the appropriate equipment, identify and characterize the products

obtained,

PEK_U02 - can use professional scientific literature and databases to plan the strategy and

tactics of the synthesis,

PEK_U03 - can choose reaction conditions of various transformations, plan the methods of

products isolation and purification,

PEK_U04 - is able to interpret the results, to evaluate the purity of the product by defining

basic physicochemical properties, to interpret spectra of organic compounds and

to write laboratory notebook in English.


Lab 1 Conducting the laboratory and completion rules. Laboratory

notebook. Basic equipment (glass and metal), and laboratory

operations. Safety issues: hazardous substances, flammable, etc.

Planning the synthesis - the use of the literature and databases.

4

Lab 2

Planning and carrying out the synthesis of two organic compounds

(2-4 step sequential processes) using different types of organic

reactions: alkylation, acylation, elimination, nucleophilic

substitution, electrophilic substitution, oxidation and reduction,

cycloaddition. Conversion of alcohols, carbonyl compounds,

carboxylic acids and their derivatives, amines, expansion of the

carbon scaffold.

Purification, identification and characterization of the products.

Interpretation of the results, writing the reports.

4

Lab 3

4

Lab 4

4

Lab 5

4

Lab 6

4

Lab 7 4

Lab 8 Revision of the laboratory equipment and reports. 2

Total hours 30

TEACHING TOOLS USED

N1 planning and execution the experiments

N2 writing reports (in English)


Evaluation


semester),


semester end)

Educational effect


achievement

C PEK_U01 –PEK_U04 Planning and preparation of two organic

compounds (2-4 synthetic steps),

characterization of the products, writing the

121

reports.


PRIMARY LITERATURE:

[31] A. Mucha, R. Siedlecka, Multistep organic synthesis. practical course, Wrocław, 2010;

[32] A. I. Vogel, Preparatyka organiczna, WNT, Warszawa, 2006;

[33] Databases: Beilstein, Chemical Abstracts, Current Contents.


[35] J. Gawroński, K. Gawrońska, K. Kacprzak, M. Kwit, Współczesna synteza

organiczna, PWN, Warszawa, 2004

SUBJECT SUPERVISOR


Renata Siedlecka, [email protected]



FOR SUBJECT

Multistep Organic Synthesis



Subject

educational

effect





Subject



number***

(skills)

PEK_U01 S2Ach4_U06 C1 Lab 2 – Lab 7 N1, N2


PEK_U03 S2Ach4_U06 C2, C3 Lab 1 – Lab 7 N1




122

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish Planowanie syntezy: strategia i taktyka

Name in English Organic synthesis design: strategies and

tactics Main field of study (if applicable) Chemistry

Specialization (if applicable) Chemistry of organic compounds and polymers






Number of hours of


University (ZZU) 30




with grade


(X) final course









COMPETENCES

20. The knowledge acquired in the extended field of Organic Chemistry

21. Knowledge of different types of reactions and their mechanisms

22. Ability to use the original chemical literature and database searches (Beilstein,

Chemical Abstracts, Current Contents)

SUBJECT OBJECTIVES

C1 Introduce students to the process of planning the synthesis of complex molecules

(retro synthetic analysis)

C2 Discuss methods of synthesis of new bonds and the transformation of functional

groups (the selectivity of the reaction)

C3 Discussion of stereochemistry in the synthesis of (Stereocontrolled reactions)

C4 Show examples of the synthesis of complex products

C5 Familiar with the terminology of the subject in English

123




PEK_W01 – know the strategy to the synthesis of (retroanalysis, synthons and

corresponding reagents, functional group transformations, the selectivity of

the reaction and the economy of the synthesis)

PEK_W02 – to understand the chemical reactivity

PEK_W03 – known classical and newer methods of C-C bond formation

PEK_W04 – stereochemistry and understood phenomenon known methods for the

preparation of chiral compounds

PEK_W05 – understand the purpose and know how to protect the functional groups

Relating to skills:


PEK_U01 – using known reactions should be able to suggest a rational synthesis of the

target molecule for moderately complex structure

PROGRAMME CONTENT


Lec 1 Target molecule functional group transformations, disconnections 4

Lec 2 Retrosynthetic analysis. Synthons and their synthetic equivalents 4

Lec 3 The technique of selective reduction, oxidation and the use of

carbanions 4

Lec 4 Classical and new methods of construction carbon-carbon bonds 4

Lec 5 The stereochemistry in the synthesis: Stereocontrolled reactions:

diastereo- and enantio-selectivities

4

Lec 6 The protection of functional groups 4

Lec 7 Strategy and tactics in the synthesis 2

Lec 8 Some examples of synthesis of the products of complex structure 4

Total hours 30

TEACHING TOOLS USED


N2 examples of problem-solving methods (derived from the original literature)

N3 discussions on how to understand / solve the problems the students received


Evaluation Educational effect Way of evaluating educational effect

124


semester),


semester end)

number achievement

F1 PEK_W01 –

PEK_W05

PEK_U01

show self-designed synthetic routes chosen

by the teacher compound

C = F1


PRIMARY LITERATURE:

[34] J. Skarzewski, Wprowadzenie do syntezy organicznej, PWN, Warszawa, 1999.

[35] P. Wyatt, S. Warren, Organic Synthesis, Strategy and Control, J. Wiley, 2007.

[36] S. Warren, Organic Synthesis, The Disconnection Approach, J. Wiley, 1984.

[37] Databases: Beilstein, Chemical Abstracts, Current Contents and original publications

in the field of organic synthesis.


[36] J. Clayden, N. Greeves, S. Warren, P. Wothers, Organic Chemistry, Oxford, 2000.

[37] L. Willis, M. Wills, Organic Synthesis, Oxford University Press, 1995.

[38] W. Carruthers, I. Coldham, Modern Methods of Organic Synthesis, Cambridge

University Press, 2004.

SUBJECT SUPERVISOR


Professor. Dr. hab. Jacek Skarżewski, jacek.skarzewski @ pwr.wroc.pl


FOR SUBJECT

Organic synthesis design: strategies

and tactics AND EDUCATIONAL EFFECTS FOR MAIN FIELD OF STUDY

Chemistry of organic compounds and polymers

Subject

educational

effect





Subject



number***

(knowledge)

PEK_W01 S2Ach3_W02 C1, C4, C5

Lec1-Lec2,

Lec7 N1-N3

PEK_W02 S2Ach3_W02 C2, C4, C5 Lec3 N1-N3

PEK_W03 S2Ach3_W02 C2, C4, C5 Lec4, Lec6 N1-N3

PEK_W04 S2Ach3_W02 C3, C4, C5 Lec5 N1-N3

PEK_W05 S2Ach3_W02 C2-C5 Lec6 N1-N3

(skills) S2Ach3_W02 C1-C5 Lec1-Lec8 N3

125

PEK_U01



126

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish: Równowagi fazowe

Name in English: Phase Equilibria Main field of study (if applicable): Chemistry



level, full-time





Number of hours of


University (ZZU) 30




with grade


(X) final course









SUBJECT OBJECTIVES

C1 Familiarization students with thermodynamics related to phase equilibria.

C2 Acquainting students with theory of chemical equilibrium

C3 Familiarization students with phase diagrams of unary, binary and ternary systems.

C4 Familiarization students with practical methods that are used in phase diagrams

construction

C5 Acquainting students with interpretation of phase diagrams

C6 Familiarization students with modeling and optimization of phase equilibria

C7 Familiarization students with development of structure of alloys and with specific

technologies based on phase diagram knowledge

127




PEK_W02 – knows theory of chemical equilibria,

PEK_W03 – knows different types of phase diagrams of unary, binary and ternary systems,

PEK_W04 – can correctly make interpretation of phase diagrams,

PEK_W05 – knows how to make modeling and optimization of phase diagrams,

PEK_W06 – has basic knowledge concerning development of alloys microstructure,

PEK_W07 – knows specific technologies based on phase diagram knowledge.

PROGRAMME CONTENT


Lec1 Thermodynamic activities, chemical potentials, thermodynamics

description of condensed phases 2

Lec2 Thermodynamic stability of condensed phases, Gibbs Free entalpy

(G), Gibbs rule for multicomponent systems. 2

Lec3 Chemical equilibrium 2

Lec4 Basic Structure of Materials; mechanical properties, phases and

crystal structures, phase diagrams. 2

Lec5 Phase equilibria and diagrams for binary and ternary systems:

isothermal and compositional sections. 4

Lec6 Chemical compounds and phases / intermetallic phases. „Point”

stoichiometric compounds and compounds/phases of homogeneity

ranges.

2

Lec7

Interpretation of phase diagrams: solubility limits, lever rule,

microstructure, atomic and ionic substitution, doped materials,

defected structures, polymorphic structures, eutectics, perytectics,

eutectoids. 2

Lec8

Practical remarks concerning phase diagram determination on the

basis of Thermal Analysis (TA), Differential Thermal Analysis

(DTA) and Differential Scanning Calorimetry (DSC)

2

Lec9 Thermodynamics of Solutions: enthalpy of mixing.entropy of mixing.

Gibbs energy of mixing, making phase diagrams 2

Lec10 CALPHAD modelling of phase equilibria: modelling of Cp, H and S

for individual phases, lattice stability, optimization of thermochemical functions and phase diagram.

2

Lec11 Diffusion, Nucleation and Growth: homogenisation, processing of Al

alloys, nucleation and growth of a new phase 2

Lec12 Transformation kinetics: nucleation Rates, growth of a new phase.

isothermal transformation diagrams. 2

Lec13 Microstructure and properties of plain carbon steels: equilibrium 2

128

cooling of steels, non-equilibrium cooling of steels. TTT diagrams

Lec14

Specific technologies based on phase diagram knowledge: metallic

glasses, refractory metals and ceramics (Tungsten, Tantalum,

carbides, oxides, ceramics), polymorphic phase transitions used for

the modern data storage (GeSbTe). 2

Total hours 30

TEACHING TOOLS USED



Evaluation


semester),


semester end)


achievement



PRIMARY LITERATURE:

[1]. W. D. Callister Jr., Materials Scienec and Engineering; An Introduction, John Wiley &

Sons, 6th

Edition, 2003

[2]. F. Tamás and I. Pál, Phase equilibria spatial diagrams. Phase diagrams. Their

interpretation and anaglyph representation, Iliffe Books, 1970.

[3]. A Cottrell. An Introduction to Metallurgy, 2nd Ed., Institute of Materials, London, UK,

1995.

[4]. RE Smallman. Modern Physical Metallurgy, 4th Ed., Butterworths, 1985.


[1]. O. Kubaschewski, C.B. Alcock & P.J. Spencer, Materials Thermochemistry,: 6th edition.

Pergamon, 1993.

SUBJECT SUPERVISOR


D.Sc. Leszek Rycerz, prof.; [email protected]

129


FOR SUBJECT

Phase Equilibria


Chemistry

Subject





Subject



number***

(knowledge)





PEK_W05 S2Ach5_W03 C5 Lec2-9-Lec10 N1





130

Zał. nr 4 do ZW 64/2012

FACULTY OF CHEMISTRY / DEPARTMENT of HUMANITIES

SUBJECT CARD

Name in Polish Filozofia nauki i techniki

Name in English Philosophy of science and technology Main field of study (if applicable):

Specialization (if applicable):


Kind of subject: obligatory

Subject code FLC024004

Group of courses NO


Number of hours of


University (ZZU)

15




with grade Examination /

crediting with

grade*

Examination /

crediting with

grade*

Examination /

crediting with

grade*

Examination /

crediting with

grade*

For group of courses

mark (X) final course



points for practical (P)

classes



student contact (BK) classes

0.5



1. Non

\

SUBJECT OBJECTIVES C1 To acquaint students with specificity of philosophical reflection about science and technology. C2 Systematize and deepen the knowledge of the basic methods of inference that regulate and organize

our knowledge.

C3 Performance considerations of engineer’s activity and to present the issue of social responsibility in

science and technology.



PEK_ HUM W07 The student gains knowledge of the basic methods of inference (deduction,

induction and abduction).

PEK_ HUM W08 The student has knowledge that is essential to understanding and interpreting

social and philosophical considerations of engineer’s activity.

Relating to social competences:

PEK_HUM K01 The student is aware of the importance of understanding non-technical

aspects and of engineer’s activity, its consequences and responsibility for undertaken

decisions.

131

PROGRAMME CONTENT


Lec 1,2 What is the science and technology? The basic concepts and principles

of the philosophy of science and philosophy of technology.

2

Lec 3 The main criteria of scientific knowledge. 1

Lec 4 The tradition of doing science from the point of view of the theory 1

Lec 5 The tradition of doing science from the point of view of the experiment. 1

Lec 6 The basic methods of inference – induction. 1

Lec 7 The basic methods of inference – deduction. 1

Lec 8 The basic methods of inference – abduction. 1

Lec 9,10 The main objectives and functions of science and technology

from the point of view of classical philosophy of science.

2

Lec 11 The main aims and functions of science and technology

from the point of view of the sociology of scientific knowledge.

1

Lec 12, 13 The concept of science laboratory. 2

Lec 14, 15 The problem of social responsibility of science and technology. 2

Total hours 15

Form of classes – class Number of

hours

Cl 1

Cl 2

Cl 3

Cl 4

..

Total hours

Form of classes – laboratory Number of

hours

Lab1

Lab2

Lab3

Lab4

Lab5

…

Total hours

Form of classes – Project Number of

h

o

u

r

s

Proj1

Proj2

Proj3

Proj4

…

132

Total hours

Form of classes – seminar Number of

hours

Sem1

Sem2

Sem3

…

Total hours

TEACHING TOOLS USED

N1. Multimedia presentation.

N2. Lecture

N3. Interactive lecture


Evaluation(F – forming

(during semester), P –

concluding (at

semester end)

Educationaleffectnumber Way of evaluating educational effect

achievement

F1 PEK_ HUM W07

PEK_ HUM W08

PEK_ HUM K01

Passing test, active participation in lectures

P=F1


PRIMARY LITERATURE:

[38] E. Agazzi, Dobro, zło i nauka. Etyczny wymiar działalności naukowo-technicznej,

Warszawa 1997;

[39] S. Blackburn, Oksfordzki słownik filozoficzny, Warszawa 2004;

[40] A. Chalmers, Czym jest to, co zwiemy nauką, Wrocław 1997;

[41] R. M. Chisholm, Teoria poznania,1994;

[42] Ch. Frankfort- Nachmiast, D. Nachmiast, Metody badawcze w naukach społecznych,

Poznań 2001;

[43] A. Grobler, Metodologia nauk, Kraków 2004;

[44] M. Heidegger, Budować, mieszkać, myśleć, Warszawa 1977;

[45] T. Kuhn, Dwa bieguny, Warszawa 1985;

[46] B. Latour, Polityka natury, Warszawa 2009;

[47] K.R. Popper, Wiedza obiektywna, Warszawa 1992;

[48] J. Woleński, Epistemologia, Warszawa 2005.


[39] [1] D. Sobczyńska, P. Zeidler, Nowy eksperymentalizm. Teoretycyzm. Reprezentacja,

Poznań 1994,

[40] P. Zeidler, Spór o status poznawczy teorii, Poznań 1992.


Marek Sikora [email protected]


133

MATRIX OF CORRELATION BETWEEN EDUCATIONAL EFFECTS FOR

SUBJECT Philosophy of science and technology

AND EDUCATIONAL EFFECTS IN THE FIELD OF TECHNICAL

SCIENCES Subject educational effect Correlation between

subject educational

effect and

educational effects

defined for main

field of study and

specialization (if

applicable)**

Subject

objectives*** Programme content*** Teaching tool

number***

PEK_ HUM W07;

PEK_ HUM W08

(knowledge)

T2A_W07

T2A_W08

C1, C2 Lec1-Lec9 N1, N2

PEK_HUMK01 (competences) T2A_K01 C1 Lec1, Lec10-Lec15 N1, N2, N3


*** - from tableabove

134

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SUBJECT CARD

Name in Polish Fizyczna chemia organiczna

Name in English Physical organic chemistry Main field of study (if applicable)

Specialization (if applicable) Medicinal chemistry

Level and form of studies: 1st/ 2nd* level, full-time





Number of hours of


University (ZZU) 15




with grade


(X) final course








COMPETENCES

23. Knowledge of organic chemistry, theoretical and practical

SUBJECT OBJECTIVES

C1 Learning the type of molecular interactions

C2 Learning the basic kinetic and thermodynamic phenomena

C3 Learning acid base interaction

C4 Learnng basics of reaction mechanism in organic chemistry

C4 Learning the symmetry relation within molecule

135



PEK_W01 – He understands the basic thermodynamics.

PEK_W02 – He is able to write and predict reaction mechanism

PEK_W03 – He is able to define the symetry of the molecule

PEK_W04 – He is able to define the type of intra and inter molecular interactions

PROGRAMME CONTENT


Lec 1-2 Bonds in organic chemistry 2

Lec 3-4 Intermolecular forces 2

Lec 5-6 Reactive intermediates 2

Lec 7-8 Reaction mechanism , nucleophilic and electrophilic mechanism 2

Lec 9-10 Reaction mechanism , radical mechanism 2

Lec 11-12 Symetry of molecules 2

13-14 Acid base equilibria 2

Lec 15 Evaluation test 1

Total hours 15

TEACHING TOOLS USED

N1 Lecture with multimedial presentation


Evaluation


semester),


semester end)

Educational effect


achievement

P1 W1-W15 test

136


PRIMARY LITERATURE:

[49] Bruckner Bernard Organic mechanisms, reactions, stereochemistry and synthesis

[50] Jones Richard, Physical and mechanistic organic chemistry

[51] Carter Robert, Molecular symmetry and group theory


[41] Ilich, Predrag Peter, Selected problems in physical chemistry

[42] Deslongchamps, Stereoelectronis effects in organic chemistry

[43] Jaffe, Hans Symmetry in chemistry

SUBJECT SUPERVISOR


Roman Gancarz, [email protected]


FOR SUBJECT

Physical organic chemistry


Medicinal Chemistry

Subject

educational

effect





Subject



number***

(knowledge)

PEK_W01 S2Ach4-W07 C1 Le1-Le4 N1

(knowledge)


(knowledge)


(knowledge)

PEK_W04 S2Ach4-W07 C1 ,C3 Le1-Le4 N1



138

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SUBJECT CARD

Name in Polish Podstawy Chemii Fizjologicznej

Name in English Principles of Physiological Chemistry Main field of study (if applicable) Chemistry







Number of hours of


University (ZZU) 30





/ crediting

with grade*

Examination

/ crediting

with grade*

Examination

/ crediting

with grade*

Examination

/ crediting


(X) final course

Number of ECTS points including number of ECTS







COMPETENCES

1. The student knows biology on the high school level.

SUBJECT OBJECTIVES

C1 Knowledge of chemical compounds that build a living organism.

C2 Understanding the basic laws governing the metabolism of living organisms.

C3 Understanding the basic laws governing selected biochemical processes

139



PEK_W01 is familiar with the basic principles of biochemistry

PEK_W02 knows structures and functions of main types of macromolecules

PEK_W03 has a basic knowledge of energy conversions occurring in living organisms

PEK_W04 is able to characterize the biochemical process

PROGRAMME CONTENT


Lec 1 From amino acids and peptides to proteins and their function. 2

Lec 2 Structure and functioning of DNA and RNA. 2

Lec 3 Structure and functioning of fatty acids. 2

Lec 4 Carbohydrates and their function. 2

Lec 5 Small molecules in signal transduction. 2

Lec6 Structure and functioning of membrane. 2

Lec 7 Review of cytoplasmic organelles. 2

Lec 8 Meiosis and Mitosis 2

Lec 9 Cell death processes. 2

Lec 10 Processes of intra and extracellular signal transduction. 2

Lec 11 Processes of intra and extracellular metabolism regulation. 2

Lec 12 Additional comments. 2

Lec 13 Seminar. 2

Lec 14 Seminar. 2

Lec 15 Seminar. 2

Total hours 30


Evaluation


semester),


semester end)

Educational effect


achievement

F1 PEK_W01 do

PEK_W04

Participation in the lectures

C – grade for quality of presented seminar

140


PRIMARY LITERATURE:

[52] Jeremy M. Berg, Lubert Stryer, John L. Tymoczko , Biochemistry, Sixth Edition

[53] John C. McMurry . Organic Chemistry


[44] Pharmaceutical Bioassays – Methods and Applications, Shiqi Peng, Ming Zhao, Wiley

2009

SUBJECT SUPERVISOR


Dr hab. Marcin Drąg, prof. Pwr, [email protected]


FOR SUBJECT

Principles of Physiological Chemistry


Medicinal Chemistry

Subject

educational

effect





Subject



number***

(knowledge)

PEK_W01 K1Ach_W15 C1

Lec3, Lec 5,

Lec 7, Lec 6

N1

PEK_W02 K1Ach_W15

C1 Lec 1, Lec 2,

Lec 4,

N1

PEK_W03 K1Ach_W15 C2 Lec 10, Lec 11 N1

PEK_W04 K1Ach_W15

C3 Lec 8, Lec 9,

Lec 12

N1




141

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SUBJECT CARD

Name in Polish Polimery w medycynie

Name in English Polymers in medicine Main field of study (if applicable) Chemistry

Specialization (if applicable) Medicinal chemistry

Level and form of studies: 1st/ 2nd* level, full-time





Number of hours of


University (ZZU) 15




with grade


(X) final course








COMPETENCES

24. Completed course of organic chemistry

25.

SUBJECT OBJECTIVES

C1 To show how polymers can be used in medicine

C2 To describe specificity of polymers

C3 To allow designing of new medical appliances from polymers

142



PEK_W01 – to have a knowledge on preparation and properties of polymers

PEK_W02 – to know the place of polymers in construction of drug delivery systems

PEK_W03 – to know how to use polymers as artificial implants,

PEK_W04 – is able to predict the use of particular polymer

PROGRAMME CONTENT


Lec 1 History of polymers, definitions, properties of polymers 2

Lec 2 Molecular weights, polydispersity, determination of molecular weight 2

Lec 3 Polyaddtion and polycondensation, properties of polymers 2

Lec 4 Soluution of polymers, Thermodynamics, phase separation 2

Lec 5 Polymers in condensed phase, blends, phase transitions, characteristic

temperatures 2

Lec 6 Mechanical properties of polymers 2

Lec 7 Surfaces, modification and evaluation 2

Lec 8 Transport phenomena in polymers, Fickian an abnormal diffusion 2

Lec 9 Artificial kidney – history and perspectives 2

Lec 10 Artificial organs: liver, lung and skin 2

Lec 11 Polymer scaffolds, preparation and the use in tissue emgineering 2

Lec 12 Polymer auxalities in medicine and pharmacy 2

Lec 13 Polymers in drug production, separation, membrane systems, polymers in

water treatment 2

Lec 14 Discussion forum on the use of polymes to implants 2

Lec 15 Discussion forum on the use of polymers in designing of new drugs 2

Total hours 30

TEACHING TOOLS USED

N1 Lecture

N2 Consultations


Evaluation


semester),


semester end)

Educational effect


achievement

F1 Lecture Activity

143

6 suggestions on the use of polymers 5.5 (A)

5 suggestions on the use of polymers 5 (B)

4 suggestions on the use of polymers 4.5 (C)

3 suggestions on the use of polymers 4 (D

2 suggestions on the use of polymers 3,5 (E

1 suggestion on the use of polymers 3 (E

C


PRIMARY LITERATURE:

[54] M.Bryjak, I.Gancarz, Polymers in medicine, wyd PWr 2010


[45] L.H.Sperling, Introduction to physical polymer science

[46] F.Billmayer, Textbook of polymer science,

SUBJECT SUPERVISOR


Marek Bryjak, [email protected]


FOR SUBJECT

Polymers in medicine


Chemistry

Subject

educational

effect





Subject



number***

(knowledge)

PEK_W01 S2Ach4_W05 C2 W1-W8 N1, N2

PEK_W02 S2Ach4_W05 C1, C3 W9-W13, W15 N1, N2

PEK_W03 S2Ach4_W05 C1, C3 W9-W13, W14 N1, N2

PEK_W04 S2Ach4_W05 C1, C3 W14, W15 N1, N2




144

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SUBJECT CARD

Name in Polish Podstawy Chemii Fizjologicznej

Name in English Principles of Physiological Chemistry

Main field of study (if applicable) Chemistry







Number of hours of


University (ZZU) 30





/ crediting

with grade*

Examination

/ crediting

with grade*

Examination

/ crediting

with grade*

Examination

/ crediting


(X) final course

Number of ECTS points including number of ECTS







COMPETENCES

1. The student knows biology on the high school level.

SUBJECT OBJECTIVES

C1 Knowledge of chemical compounds that build a living organism.

C2 Understanding the basic laws governing the metabolism of living organisms.

C3 Understanding the basic laws governing selected biochemical processes

145



PEK_W01 is familiar with the basic principles of biochemistry

PEK_W02 knows structures and functions of main types of macromolecules

PEK_W03 has a basic knowledge of energy conversions occurring in living organisms

PEK_W04 is able to characterize the biochemical process

PROGRAMME CONTENT


Lec 1 From amino acids and peptides to proteins and their function. 2

Lec 2 Structure and functioning of DNA and RNA. 2

Lec 3 Structure and functioning of fatty acids. 2

Lec 4 Carbohydrates and their function. 2

Lec 5 Small molecules in signal transduction. 2

Lec6 Structure and functioning of membrane. 2

Lec 7 Review of cytoplasmic organelles. 2

Lec 8 Meiosis and Mitosis 2

Lec 9 Cell death processes. 2

Lec 10 Processes of intra and extracellular signal transduction. 2

Lec 11 Processes of intra and extracellular metabolism regulation. 2

Lec 12 Additional comments. 2

Lec 13 Seminar. 2

Lec 14 Seminar. 2

Lec 15 Seminar. 2

Total hours 30


Evaluation


semester),


semester end)

Educational effect


achievement

F1 PEK_W01 do

PEK_W04

Participation in the lectures

C – grade for quality of presented seminar

146


PRIMARY LITERATURE:

[55] Jeremy M. Berg, Lubert Stryer, John L. Tymoczko , Biochemistry, Sixth Edition

[56] John C. McMurry . Organic Chemistry


[47] Pharmaceutical Bioassays – Methods and Applications, Shiqi Peng, Ming Zhao, Wiley

2009

SUBJECT SUPERVISOR


Dr hab. Marcin Drąg, prof. Pwr, [email protected]


FOR SUBJECT

Principles of Physiological Chemistry


Medicinal Chemistry

Subject

educational

effect





Subject



number***

(knowledge)

PEK_W01 K1Ach_W15 C1

Lec3, Lec 5,

Lec 7, Lec 6

N1

PEK_W02 K1Ach_W15

C1 Lec 1, Lec 2,

Lec 4,

N1

PEK_W03 K1Ach_W15 C2 Lec 10, Lec 11 N1

PEK_W04 K1Ach_W15

C3 Lec 8, Lec 9,

Lec 12

N1




147

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SUBJECT CARD

Name in Polish: Pirometalurgia

Name in English: Pyrometallurgy Main field of study (if applicable): Chemistry



level, full-time





Number of hours of






with grade


(X) final course





contact (BK) classes 1 1.5




SUBJECT OBJECTIVES

C1 Familiarization students with theory of chemical equilibrium.

C2 Acquainting students with thermodynamics related to the metallurgical processes.

C3 Familiarization students with reaction kinetics, process rate, transport phenomena in

metallurgy.

C4 Familiarization students with unit operations of metallurgical processes

C5 Acquainting students with theory of metallurgical processes

C6 Familiarization students with technological processes that are use for production of

Fe, Cu, Pb, Zn

C7 Familiarization students with environmental aspects of pyrometallurgy

C8 Teaching students a practical performing of unit processes of pyrometallurgy in


148

C9 Acquainting students with software used for calculation and modeling of

thermodynamic equilibria of chemical reactions from area of pyrometallurgical

processes


pyrometallurgical processes






PEK_W02 – knows theory of metallurgical processes,

PEK_W03 – knows basis of reaction kinetics, process rate, transport phenomena in

metallurgy ,

PEK_W04 – knows unit operations that are used in pyrometallurgy,

PEK_W05 – knows theoretical background of pyrometallurgical processes,

PEK_W06 – has basic knowledge concerning metallurgical processes for production Fe,

Cu,Pb, Zn,

PEK_W07 – knows environmental aspects of pyrometallurgy.

Relating to skills: PEK_U01 – can perform basic calculations related to the realization of selected unit

operation of pyrometallurgical process

PEK_U02 – can perform basic thermodynamic calculation with appropriate software

PEK_U03 – can construct alone measuring system



investigation

PEK_U06 – can operate basic equipment used in laboratory of high-temperature processes

PEK_U07 – is capable to optimize the parameters of selected pyrometallurgical process


conclusion

PEK_U09 – is capable to present experimental results as multimedia presentation


PROGRAMME CONTENT


Lec1 Chemical equilibrium, melts and solutions, thermochemical software 2

Lec2 Coulombic fluids, molten salts 2

Lec3 Reaction kinetics, process rate, transport phenomena in metallurgy 2

Lec4 Fuels and ore preparation 2

Lec5 Reduction 2

Lec6 Refining 2

Lec7 Vaporization and fuming 2

Lec8 Slags and refractories 2

149

Lec9 Sulfide processing 2

Lec10 Chlorides and chlorination 2

Lec11 Metallurgy of iron 2

Lec12 Metallurgy of copper 2

Lec13 Metallurgy of lead 2

Lec14 Metallurgy of zinc 2

Lec15 Metallurgy vs. environment 2

Total hours 30

PROGRAMME CONTENT


Lab1 Preparation of synthetic slag 6

Lab2 Reduction of copper oxide to copper alloys 6

Lab3 Oxidative refining of molten metal 6

Lab4 Roasting of lead sulfide 6

Lab5 Kinetics of sulfide oxidation 6

Lab6 Carbochlorination of oxides 6

Lab7 Reduction of cobalt chloride with hydrogen 6

Lab8 Oral presentation (with discussion) of the consolidated report

from tests 3

Total hours 45

TEACHING TOOLS USED




N4 Software utilization


N6 Multimedia presentation (presentation of experimental results)


Evaluation


semester),


semester end)


achievement


F1(laboratory) PEK_U01 – PEK_U08,

PEK_U10

mean value from 7 small written exams

F2 (laboratory) PEK_U01 – PEK_U08,

PEK_U10

Mean value from 7 lab reports

F3 (laboratory) PEK_U09 Multimedia presentation of lab. results

C2(laboratory) PEK_U01 – PEK_U10 (F1+F3+F3)/3

150


PRIMARY LITERATURE:

[1]. Chiranjib Kumar Gupta, Chemical Metallurgy: Principles and Practice, , 2003 WILEY-

VCH Verlag GmbH & Co. KGaA, Weinheim

[2]. Terkel Rosenqvist, Principles of extractive metallurgy, Tapir Akademisk Forlag,

Trondheim 2004

[3] L.Coudurier, D.W.Hopkins, I.Wilkomirsky, Fundamentals of metallurgical

processes, Pergamon Press, Oxford 1978

[4] A. Volsky, E. Sergievskaya, Theory of Metallurgical Processes, Mir Publishers, Moscow


[1]. O. Kubaschewski, C.B. Alcock & P.J. Spencer, Materials Thermochemistry,: 6th edition.

Pergamon, 1993.

[2]. Fathi Habashi, Principles of extractive metallurgy, vol.3, Pyrometallurgy, Gordon and

Breach Science Publishers, S.A. 1985

SUBJECT SUPERVISOR


Prof. Wlodzimierz Szczepaniak, [email protected]



FOR SUBJECT

Pyrometallurgy


Chemistry

Subject





Subject



number***

(knowledge)








151

(skills)


Lab1-Lab7

N2-N5








PEK_U09 S2Ach5_U05 C11 Lab8 N6




152

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SUBJECT CARD

Name in Polish Racjonalne projektowanie leków

Name in English Rational drug design Main field of study (if applicable) Biotechnology, Chemistry

Specialization (if applicable) Bioinformatics, Medicinal Chemistry



Subject code BTC024014



Number of hours of


University (ZZU)

30



Form of crediting drug design


(X) final course








COMPETENCES

26. Knowledge of basic organic chemistry

27. Knowledge of basic biology

SUBJECT OBJECTIVES

C1 Acquaintance with principles of design of biologically active substances

C2 To acknowledge economic aspects of drug design

C3 To ackonwlege principles of targetes therapy

C4 Acquaintance with principles of gene therapy

153


Student who finished the course:

Relating to knowkedge:

PEK_W01 – knows basic principles of dug design,

PEK_W02 – is able to propose suitable method of drug design in dependence of the level of

knowledge about physiologic process involved,

PEK_W03 – understands economical aspects and time-limitations of design of drug design,

PEK_W04 – understands economic and physiologic outcomes of drug design.

Relating to skills:

PEK_U01 – is able to propose the method for the design of drug against certain illness.

PROGRAMME CONTENT


Lec 1 Economics of drug design and development. Cost and time

required to introduce new drug to the market. Generic drugs.

Globalization. 2

Lec 2 Randomized screening. Historical perspective. Illustration of the

opinion of Louyis Pasteur „Fortune favors prepared minds”. Case

studies.

2

Lec 3

Natural products as a source of drugs. History of the discovery of

aspirin, morphine, artemisinin, quinine, penicillin and taxol. Current

trends in natural drug research.N

2

Lec 4

Choice of the target. HIV as an example for choice of the target for

drug design. 2

Lec 5 Theory of structural analogy. Historical perspective

(sulfonamides). Direct similarity versus topological one with

analogs of morphine and anti-influenza drugs as examples.

2

Lec 6 Theory of structural analogy. Chemical outlook, trics and “magic

methods”. Peptidomimetics. 2

Lec 7 Three-dimensional structure of receptors as a basis for drug

design. Construction of pharmacophore. Computer-aided methods

for drug design – QSAR and molecular modeling. Receptor

flexability.

2

Lec 8 Topological conformity. Antagonists and agonists. Natural

peptides as scaffolds. 2

Lec 9 Covalent drugs – enzyme killers. Overview of functional groups

able for irreversivble bonding with proteins. Techniques of design

of covalent drugs. Case studies.

2

Lec 10 Suicidal drugs (suicide substrates) – Troian horses of enzymatic

reactions. Overview of the techniques leading to suicide substrates.

Types od inhibition after conversion of suicidal drug into real

inhibitor.

2

Lec 11 Transition-state analogues. Techniques used for the identification

of transition state. Pauling's theory of the course of enzymatic

reaction. Construction of transition-state analogues. Computer-aided

2

154

techniques.

Lec12 Selective complexation of metalloenzymes. History of the

discovery of captopril. Convertase as a target for anti-hypertensive

drugs. Choice of ligand.

2

Lec13 Drug targeting and delivery. Invasive drug delivery (catheters,

stents, microdialysers etc.). Nano-carriers – liposomes, vesicles,

dendrimers, antibodies, proteins, nanopolymers and nanoparticels.

Bacterial ghosts and virosomes. Prodrugs. Engineered metabolic

activation. Targeted enzyme prodrug therapy.

2

Lec14 Gene therapy. Lacking gene delivery. Anti-sense oligonucleotides,

siRNAs, rybosymes. 2

Lec15 Evaluation and grading of projects. 2

Total hours 30

TEACHING TOOLS USED

N1 Lecture and multimedia presentatio

N2 Preparation of project

N3 Interaktive system of consultation of project dvelopment


Evaluation


semester),


semester end)

Educational effect

number

Way of evaluating educational effect

achievement

P (lecture) PEK_W01 up to

PEK_W04

PEK_U01

Drug design for chosen illness

155


PRIMARY LITERATURE:

6. K. M. Merz, Drug Design, structure and Ligand-Based Approaches, Cambridge

University Press, 2010

7. Medicinal Chemistry and Drug Design, e d. D. Dnkici, Intech (open access), 2012


3. Design of Drugs: Basic Principles and applications, ed. J. H. Poupaert, Marcel Dekker,

2002

4. The Organic Chemistry of Drug Design and Drug Action, Academic Press, 2004

5. Virtual Screening. ed. M. O. Taha, Intech (open access), 2012

6. Drug Development – A Case study Based Insight intor Modern Startegies, Intech

(open access), 2011

SUBJECT SUPERVISOR


Prof.dr hab. inż. Paweł Kafarski, [email protected]


FOR SUBJECT

Rational drug design


Biotechnology & Chemistry

Subject

educational

effect





Subject

objectives***

Programme

content***

Teaching tool

number***

(wiedza)

PEK_W01

PEK_W04

S2Ach4_W01, S2Ach4_W10,

S2bt5_W04 C1, C2 Lec1 – Lec 3 N-jeden


S2bt5_W04 C1 Lec 2, Lec 3 N1

PEK_W03 S2Ach4_W10, S2bt5_W04,

S2bt5_W02 C1,C3

Lec 2, Lec 5-

Lec 14 N-jeden

PEK_U01 S2Ach4_W10, S2bt5_W04 C1 Lek15 N2, N3



156

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SUBJECT CARD

Name in Polish Informacja naukowa i techniczna w biotechnologii

Name in English Retrieval of scientific and technical

information Main field of study (if applicable) Biotechnology, Chemistry

Specialization (if applicable) Bioinformatics, Medicinal chemistry


level, full-time


Subject code INC024008



Number of hours of


University (ZZU) 15




with grade


(X) final course








COMPETENCES

28. Basic computer science skills

29. Communication in English language

SUBJECT OBJECTIVES

C1 Teaching practical use of computer network services

C2 Teaching basic concepts of scientific literature

C3 Teaching practical use of scientific literature databases

C4 Taching practical use of factographic databases

C5 Teaching basic concepts of funding scientific research

C6 Teaching basic concepts of ethical problems in science and engineering

157



PEK_W01 – knowledge of elementary computer network services

PEK_W02 - knowledge of the structure and preparing scientific publications and major

scientific literature databases.

PEK_W03 - knowledge of the major factographic chemical and biotechnological

databases.

PEK_W04 - knowledge of the major agencies funding research and development

PEK_W05 - knowledge of the typcal ethical problems in science and technology.

Relating to skills:

PEK_U01 – ability to transfer information between different computer systems

PEK_U02 – ability to construct complex search queries in scientific literature databases

PEK_U03 - ability to construct complex search queries in factographic databases

PEK_U04 - ability to find and analyse fellowship, job and practical training offers

PEK_U05 - ability to find currently funded reasearch grants on specific topics

PEK_U06 - ability to use plagiarism checkers

PROGRAMME CONTENT

Form of classes – laboratory Number of hours

La1 Initial information, assigning accounts, Structure and composing

scientific texts

2

La2 Web of Science literature database, composing search queries 2

La3 Science citation index and various uses of impact factors 2

La4 Cambridge Structural Database, Analysis of structural information 2

La5 Research grant databases, fellowships, job and practical training

offers, preparing CV and job interviews

2

La6 Patent databases 2

La7 Beilstein database and Reaxys, Chemical Abstracts database and

Scifinder

2

La8 Ethical problems in science and industry, Individual report grading 1

Total 15

TEACHING TOOLS USED

N1 Multimedia presentation

N2 Solving problems

N3 Use of compter software to solve problems

158


Evaluation


semester end)

Educational effect


achievement

C PEK_U02 Final report maximum 100 score points

grade 3.0 for 50-60 score points






C PEK_U03

C PEK_U04

C PEK_U05


PRIMARY LITERATURE:

[1] D. Ridley, Finding scientific information – information retrieval, Wiley, 2002

SUBJECT SUPERVISOR


W. Andrzej Sokalski, [email protected]


FOR SUBJECT

Retrieval of scientific and technical information in biotechnology


Bioinformatics, medicinal chemistry

Subject

educational

effect





Subject


kontent*** Teaching tool

number***

(knowledge)

PEK_W01 T2A_U01 T2A_U07, X2A_U03 C1 La1 N1

PEK_W02 T2A_U01 T2A_U07, X2A_U03 C2 La2, La3 N2,N3

PEK_W03 T2A_U11 InzA_U05, X2A_U03 C3 La4, La6,La7 N1,N2,N3

PEK_W04 T2A_U11 InzA_U05, X2A_U03 C4 La5 N1,N3


159

PEK_W05 T2A_U11 InzA_U05, X2A_U03 C5 La8 N1,N3

(comptence)

PEK_U01 T2A_U01 T2A_U07, X2A_U03 C1 La2 N2,N3

PEK_U02 T2A_U01 T2A_U07, X2A_U03 C3 La4,La6 N2,N3


PEK_U04 T2A_U01 T2A_U07, X2A_U03 C5 La5 N3




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SUBJECT CARD

Name in Polish Wybrane reakcje w chemii organicznej

Name in English Selected reactions in organic chemistry Main field of study (if applicable) Chemistry







Number of hours of


University (ZZU) 30




with grade


(X) final course









COMPETENCES

1 Passed lecture on "Principles of Organic Chemistry"

2 Knowledge of the basic mechanisms of organic reactions

3 Knowledge of English

SUBJECT OBJECTIVES

C1 Presentation of the basic classes of organic compounds including the question of

isomerism, stereochemistry, and the most important characteristic of the reaction of

functional groups.

C2 Presentation of the selected mechanisms of organic name reactions, and a number of

other reactions.

C3 Discussion of the mechanisms of organic reactions such as addition, elimination,

radical substitution, electrophilic and nucleophilic substitution

C4 Discussion of pericyclic reaction.

C5 Discussion of the reactions of organometallic compounds.

C6 Discussion of the planning principles established synthesis of the target molecule

161




PEK_W01 – knows the basic classes of organic compounds including the question of

isomerism, stereochemistry, and the most important characteristic of the

reaction of functional groups.

PEK_W02 – know the mechanisms of organic reactions such as addition, elimination,

substitution radical, electrophilic and nucleophilic and selected name reactions

PEK_W03 – known reactivity of organometallic compounds and phosphorous- and sulfur

organic compounds and examples of their use in the synthesis

PEK_W04 – known selective reduction methods and selective oxidation method used in

organic chemistry

PEK_W05 – understand the purpose and know how to protect the functional groups

PEK_W06 – know what to do when planning a synthesis of the target molecule for

moderately complex structure

PROGRAMME CONTENT


Lec 1 Electronic structure of organic compounds. 2

Lec 2 Molecular architecture – elements of stereochemistry. 2

Lec 3 Reaction equilibrium and rate. 2

Lec 4 Intermediates, transition state. 2

Lec 5 Reactions of aromatic compounds. 2

Lec 6 Reactions of carbonyl compounds. 2

Lec 7 Reactions of some organometallic compounds (Li, Mg, Zn,...). 2

Lec 8 Reactions of organophosphorous and sulfur compounds. 3

Lec 9 Pericyclic reactions. 2

Lec 10 Selective methods for reductions of organic compounds. 2

Lec 11 Selective methods for oxidations of organic compounds. 2

Lec 12 Ideas of organic synthesis. 2

Lec 13 Selective transformations and protections of functional groups. 3

Lec 14 Targeted synthesis. 2

Total hours 30

TEACHING TOOLS USED


162


Evaluation


semester),


semester end)

Educational effect


achievement

credit on the basis of student's attendance


PRIMARY LITERATURE:

[57] J. Clayden, N. Greeves, S. Warren, P. Wothers, Organic Chemistry, Oxford, 2000;

[58] J. McMurry, Chemia organiczna, tom 1 – 5, PWN, Warszawa, 2005;

[59] Michael B. Smith, Jerry March, March’s Advanced Organic Chemistry, Wiley, 2000.

[60] J. Skarzewski, Wprowadzenie do syntezy organicznej, PWN, Warszawa, 1999.


[48] L. G. Wade, Organic Chemistry, Prentice Hall, Upper Saddle River, NJ, 2006.

SUBJECT SUPERVISOR


Professor. Dr. hab. Jacek Skarżewski, jacek.skarzewski @ pwr.wroc.pl


FOR SUBJECT

Selected reactions in organic chemistry


Chemistry

AND SPECIALIZATION

Medicinal Chemistry

Subject

educational

effect





Subject



number***

(knowledge) optional course C1 Lec 1- Lec 3, N1

163

PEK_W01 Lec 13

PEK_W02 C2-C4 Lec 4- Lec 9 N1

PEK_W03 C5 Lec 7, Lec 8 N1

PEK_W04 C2-C5 Lec 10, Lec

11 N1

PEK_W05 C2-C5 Lec 13 N1

PEK_W06 C6 Lec 12, Lec

14 N1



164

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish Analiza specjacyjna i frakcjonowana pierwiastków

w środowisku

Name in English Speciation and fractionation analysis of

elements in the environment Main field of study (if applicable) Chemistry

Specialization (if applicable) Specialization from Chemistry field

Level and form of studies: 1st/ 2nd* level, full-time / part-time*

Kind of subject obligatory / optional / university-wide*




Number of hours of


University (ZZU) 30




with grade


(X) final course








COMPETENCES

30. Has a general knowledge in analytical chemistry

SUBJECT OBJECTIVES

C1 Basic principles devoted to the role of elements, including their speciation and

fractionation

C2 Getting to know about aspects of speciation and fractionation analysis, including

sampling and sample preparation, separation techniques and methods of detection of

the species as well as quality assurance and control of the results obtained

C3 Getting to know about speciation analysis of selected elements, e.g. As, Hg, Cr

C4 Making an awareness of the role, the need and the application of speciation

(fractionation) analysis at present times

C5 Getting to know with the proper methodology of the speciation and fractionation

analysis of elements

165




PEK_W01 – knows basic concepts of speciation and fractionation analysis of elements

PEK_W02 – knows methods of the sampling, storage and sample pre-treatments strategies

in the speciation and fractionation analysis

PEK_W03 – knows basic methods of sample preparation with the special attention of

keeping original sample composition

PEK_W04 – knows methods of fractionation of elements, including sequential extraction

procedures

PEK_W05 – knows concepts of elemental speciation for water samples

PEK_W06-PEK_W9 – knows methods applied for the extraction, chromatographic and

electrophoretic separation of species of elements

PEK_W10 – knows methods of the non-chromatographic speciaciation analysis

PEK_W11-PEK_W12 – knows instrumental detection techniques for speciation forms of

elements, including AAS, ICP-OES, ICP-MS and electrochemical methods

PEK_W13-PEK_W14 – knows general principles of quality assurance and control of

analytical results obtained

PEK_W15– knows basic concepts of speciation of selected elements, e.g., As, Hg

Relating to skills:


PEK_U01 – is able to plan stages of the analytical process required for speciation

(fractionation) analysis

PROGRAMME CONTENT


Lec 1 Introduction into speciation and fractionation analisis of elements -

basic concepts and definitions, the role and importance of speciation

(fractionation) of elements

2

Lec 2 Sampling in speciation and fractionation analysis – basic rules 2

Lec 3 Introduction into preparation of environmental samples for speciation

(fractionation) analysis – stability of species of elements, sample pre-

treatments, sample storage, basic steps applied to preparation of

various environmental samples (water, air, soil and biological

samples)

2

Lec 4 Fractionation analysis of soil/sludge samples – concepts of

fractionation, types and methods of separation of fractions of

elements, procedures of sequential extraction in practice

2

Lec 5 Speciation of elements in waters – aspects of sample preparation for

speciation analysis of water samples 2

Lec 6

Overview of methods used for separation of forms of elements,

including physical fractionation using filtration and

(ultra)centrifugation - theoretical and practical applications

2

Lec 7

Overview of extraction methods used for separation of forms of

elements, including solid phase extraction (SPE) - theoretical and

practical applications

2

166

Lec 8

Overview of electrophoretic methods used for separation of forms of

elements, including capillary electrophoresis (CE) – theoretical and

practical applications, instrumentation, sample introduction

techniques, basic types of CE methods

2

Lec 9

Overview of chromatographic methods used for separation of

speciation forms of elements, including liquid and gas

chromatography (theoretical and practical applications)

2

Lec

10

Concept of non-chromatographic speciation analysis – procedures of

determination of speciation forms of elements without the need of the

previous chromatographic separation (application of chemical vapour

generation technique for speciation analysis)

2

Lec

11

Review of spectroscopic methods of detection used for speciation

forms of elements – overview of atomic, emission and mass methods 2

Lec

12

Overview of electrochemical methods of detection used for

speciation forms of elements 2

Lec

13

Quality assurance of the results of speciation and fractionation

analysis 2

Lec

14

Quality control of the results of speciation and fractionation analysis 2

Lec

15

Speciation of the selection elements (examples) 2

Total hours 30

TEACHING TOOLS USED

N1 Informative lecture

N2 Problem lecture

N3 Multimedial presentation


Evaluation


semester),


semester end)

Educational effect


achievement

C (lecture) PEK_W01-

PEK_W15

multimedia presentation

167


PRIMARY LITERATURE:

[61] D. Barałkiewicz, E. Bulska, Specjacja chemiczna – Problemy i możliwości,

Wydawnictwo Malamut, Warszawa 2009

[62] R. Cornelis, H. Crews, J. Caruso, K. Heumann, Handbook of Elemental Speciation I:

Techniques and Methodology, John Wiley and Sons, 2003

[63] R. Cornelis, H. Crews, J. Caruso, K. Heumann, Handbook of Elemental Speciation II:

Species in the Environment, Food, Medicine and Occupational Health, John Wiley

and Sons, 2003

[64] L. Ebdon, L. Pitts, R. Cornelis, H. Crews, O.F.X. Donard, P. Quevauviller, Trace

Element Speciation for Environment, Food and Health, RSC


[49] Z. Mester, R. Sturgeon, Comprehensive Analytical Chemistry, vol. Sample

Preparation for Trace Element Analysis, Elsevier, 2003

SUBJECT SUPERVISOR


Dr hab. inż. Paweł Pohl, Prof. PWr, [email protected]


FOR SUBJECT

Speciation and fractionation analysis of elements in the environment


Chemistry

Subject

educational

effect





Subject



number***

(knowledge)

PEK_W01 C1-C4 Lec1-Lec15 N1,N2

(skills)

PEK_U01 C5 Lec1-Lec15 N3




168

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish Spektroskopia

Name in English Spectroscopy Main field of study (if applicable) Chemistry







Number of hours of






with grade


(X) final course








COMPETENCES

31. Knowledge of general chemistry

32. Basic knowledge of physical chemistry

33. Ability of using the mathematical analysis

4. Basic physicochemical calculations

5. Basic knowledge of the atomic and molecular spectroscopy.

SUBJECT OBJECTIVES

C1 Acquisition of knowledge on selected experimental methods of measuring rotational

and vibrational spectra, and on measuring equipment

C2 Acquisition of knowledge of measurement techniques of photoelectron spectra

(PES), Auger electrons and the X-ray fluorescence.

C3 Acquisition of knowledge on electron spectroscopy of polyatomic molecules

including application of the group theory in chemistry.

C4 Acquisition of knowledge on methods of detection of absorption and luminescence

spectra of polyatomic molecules, in particular of spectra with highly resolved

169

vibronic structure

C5 Acquisition of knowledge about of interpretation of two-dimensional spectra of the

nuclear magnetic resonance (COSY)

C6 Getting acquainted with selected applications of the atomic and molecular

spectroscopy



Having completed the course, the student:

PEK_W01 – has a basic knowledge on selected experimental methods of measuring

rotational and vibrational spectra, and on measuring equipment

PEK_W02 – knows principles of the spectroscopy of photoelectrons (PES), Auger electrons

and the X-ray fluorescence

PEK_W03 – has a basic knowledge of molecular spectrometry with particular reference to

electronic-vibrational spectroscopy of two- and polyatomic molecules and to

techniques allowing to acquire two-dimensional spectra of high resolution

PEK_W04 – has a knowledge on classification of molecules taking into account their

symmetry and is able to apply the group theory in chemistry.

PEK_W05 – can interprete two-dimensional spectra of the nuclear magnetic resonance

(COSY)

Relating to skills:


PEK_U01 – is able to prepare samples, and to measure and interpret vibrational spectra,

PEK_U02 – can interpret NMR spectra and, based on the interpretation, can determine

structure of an organic molecule,

PEK_U03 – is able to use UV-VIS absorption spectra to determine kinetic parameters of

photochemical reactions,

PEK_U04 – is able to use the emission spectroscopy to determine fundamental parameters

of the atomic structure

PEK_U05 –is able to interpret the fine rotational structure of vibronic bands in

spectra of diatomic molecules

Relating to social competences:


PEK_K01– acquired knowledge of the rotational, vibrational and electron spectroscopy to

the degree enabling him/her a creative use of scientific literature, and developing

and presentation of related issues..

PROGRAMME CONTENT


Lec 1 Rotational and vibrational spectroscopy, experimental methods: light

sources, Fourier techniques, detectors 4

Lec 2 Spectroscopy of photoelectrons (PES), Auger electrons and the X-ray

fluorescence. 2

Lec 3 Application of the group theory in chemistry. 2

Lec 4 Two-dimensional electron spectra of polyatomic molecules and 3

170

highly resolved vibronic luminescence spectra with the application:

spectroscopy in supersonic nozzles, spectroscopy of single

molecules, laser selection of sites.

Lec 5 Nuclear magnetic resonance (NMR) and multidimensional spectra

(COSY) 4

Total hours 15


Lab 1 Schedule of classes. Principles of the credit. Principles of the safe work in

the chemical laboratory. 2

Lab 2 Infrared spectroscopy - preparation of samples, measurements of spectra

and their interpretation. 4

Lab 3 Raman spectroscopy - preparation of samples, comparing IR and Raman

spectra 4

Lab 4 Introduction to one and of two-dimensional NMR techniques - recording

of spectra. 4

Lab 5 Analysis and interpretation of 1-D and 2-D NMR spectra 4

Lab 6 Photochromism - determination of the photochromic reaction rate constant. 4

Lab 7 Determination of atomic constants from emission spectra. 4

Lab 8 Analysis of rotational structure of N2+

spectra - determination of

rotational constants and distances between nitrogen atoms. 4

Total hours 30

TEACHING TOOLS USED

N1 Problem lectures - multimedia presentations

N2 Laboratory work - instructions to all exercises available online

N3 Independent student's work - writing reports on laboratory exercises

N4 Consultation

N5 Independent work - preparation for the final examination


Evaluation


semester),


semester end)

Educational effect


achievement

C1 PEK_W01

PEK_W02

PEK_W03

PEK_W04

PEK_W05

Grade from a written exam

F1 PEK_U01

PEK_U05

Report on exercises

171


PRIMARY LITERATURE:

[65] K. Pigoń, Z. Ruziewicz, Chemia fizyczna t 2 Fizykochemia molekularna, Wyd. PWN,

Warszawa 2007

[66] P.W. Atkins, Chemia fizyczna, PWN 2001

[67] R. M. Silverstein, F. X. Webster, D. J. Kiemle, Spektroskopowe metody identyfikacji

związków organicznych PWN, Wraszawa 2007.

[68] D. A. Skoog, D. M. West, F. J. Holler, S. R. Crouch, Podstawy chemii analitycznej 2,

PWN, Warszawa 2007.

[69] Z. Kęcki, Podstawy spektroskopii molekularnej, Wyd. PWN, Warszawa 1992.


[50] A. Cygański, Metody spektroskopowe w chemii analitycznej. WNT Warszawa, 2009

[2] J. Demichowicz-Pigoniowa, Chemia fizyczna t 3, Obliczenia fizykochemiczne, PWN,

Warszawa 2010

[3] W. Zieliński, A. Rajca, Metody spektroskopowe i ich zastosowanie do identyfikacji

związków organicznych, WNT, Warszawa 2000.

[4] J. Najbar, A. Turek, Fotochemia i spektroskopia optyczna, PWN, Warszawa 2009.

[5] P. Suppan, Chemia i światło, PWN, Warszawa 1997.

SUBJECT SUPERVISOR


dr hab. inż. Krystyna Palewska, [email protected]

172


FOR SUBJECT

Spectroscopy


Chemistry

Subject

educational

effect





Subject



number***

(knowledge)

PEK_W01

K2Ach_W03: X2A_W01, X2A_W03

X2A_W05, X2A_W06 C1 Lec1 N1, N5

PEK_W02 K2Ach_W03: X2A_W01, X2A_W03

X2A_W05, X2A_W06 C2 Lec2 N1, N5


X2A_W05’ X2A_W06 C3, C4 Lec3 N1, N5


X2A_W05, X2A_W06 C3,C4 Lec3,Lec4 N1, N5


X2A_W05, X2A_W06 C5 Lec5 N1, N5

(skills)

PEK_U01

K2Ach_U03: X2A_U01, X2A_U02

InżA_U01 C6 Lab2, Lab3 N2, N3, N4

PEK_U02 K2Ach_U03: X2A_U01, X2A_U02

InżA_U01 C6

Lab4, Lab5 N2, N3, N4


InżA_U01 C6

Lab6 N2, N3, N4


InżA_U01 C6

Lab7 N2, N3, N4


InżA_U01 C6

Lab8 N2, N3, N4

(competences)

PEK_K01

K2Ach_W03: X2A_W01, X2A_W03

X2A_W05, X2A_W06

K2Ach_U03: X2A_U01, X2A_U02

InżA_U01

C1--C6 Lec1-Lec5

Lab2-Lab8 N1-N5



173

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish Syntetyczne Leki Organiczne

Name in English Synthetic Organic Drugs Main field of study (if applicable) Chemistry







Number of hours of





Form of crediting Examination Crediting

with grade


(X) final course








COMPETENCES

34. Principles of organic chemistry, theoretical and practical.

35. Basic knowledge of biochemistry.

36. Knowledge in the field of basis of analytical chemistry is recommended.

SUBJECT OBJECTIVES

C1 Introduction to the type of drug targets.

C2 Basic important places and molecules as potential drug targets.

C3 The strategy of action of particular classes of drugs.

C4 Acquaintance with the different concepts in the field of analysis of the biological

active components of drugs, depending of the drug formulation.

C5 Gaining of the knowledge on the strategies of isolation of the biologically active

compounds from a drug form, in order to do qualitative and quantitative analyzes of

the separated substances.

174




PEK_W01 – has knowledge on the main drug targets,

PEK_W01 – has knowledge on the strategy of action of basic classes of drugs,

PEK_W02 – can define the possible mechanisms of action of main drug classes.

Relating to skills:


PEK_U01 – has skills of using different separation techniques to isolate biologically active

compounds from the different types of drug formulations,

PEK_U02 – has skills to do qualitative analysis of the biologically active components of

drugs using the characteristic reactions,

PEK_U03 – has skills to do quantitative analysis of the biologically active components of

drugs using different analytical techniques,

PEK_U04 – has skills to do synthesis of a biologically active compound and to be able to

compare it to the same isolated from a drug by qualitative analysis,

PEK_U05 – has skills to prepare a laboratory report according to Good Laboratory Practice

rules,

PEK_U06 – has skills to characterize a biologically active compound of a drug using

spectroscopic techniques: NMR, FT-IR and MS.

PROGRAMME CONTENT


Lec 1 Introduction to the type of drugs targets. 2

Lec 2 Basic important organelles in the living system, potential drug targets 2

Lec 3 Basic important biological molecules and macromolecules, potential

drugs targets. 2

Lec 4 Review on the molecular interactions important in biology. 2

Lec 5 Drugs interacting with lipids, mechanism of interaction. 2

Lec 6 Drugs interacting with lipids, mechanism of interaction. 2

Lec 7 Drugs interacting with proteins, mechanism of interaction. 2

Lec 8 Drugs interacting with DNA and RNA, mechanism of interaction. 2

Lec 9 Strategy of action of anti-fungi drugs. 2

Lec 10 Strategy of action of antiviral drugs. 2

Lec 11 Strategy of action of antibacterial drugs. 2

Lec 12 Strategy of action of anticancer drugs. 2

Lec 13 Drug metabolism and toxicity. 2

Lec 14 Elements of pharmacokinetics and pharmacodynamics. 2

Lec 15 The selected case studies part 2. 2

Total hours 30


Lab 1 Safety rules in the laboratory of organic chemistry, good laboratory 4

175

practice and the rules of the reports preparation. Introduction to the

separation and identification techniques in the organic chemistry

laboratory. NMR, FT-IR and MS spectra analyzes rules.

Lab 2 Paracetamol – quantitative and qualitative analyzes of one biologically

active ingredient drug. 4

Lab 3 NO-SPA – quantitative and qualitative analyzes of drotaverine

hydrochloride from a tablet. 4

Lab 4 Pyralginum – isolation, quantitative and qualitative analyzes of

metamizole sodium from a tablet. 4

Lab 5 Ascodan – two compounds drug – isolation and separation of

acetylsalicylic acid and codeine phosphate from a tablet. 4

Lab 6 Ascodan – two compounds drug - quantitative and qualitative analyzes of

acetylsalicylic acid and codeine phosphate. 4

Lab 7 Etopiryna – three compounds drug in a tablet form –separation techniques

in the isolation of acetylsalicylic acid, ethenzamide and caffeine. 4

Lab 8 Etopiryna – three compounds drug in a tablet form – qualitative and

quantitative analyzes of acetylsalicylic acid, ethenzamide and caffeine. 4

Lab 9 Cardiamidum – a drug in a form of drops (liquid formulation) -

quantitative and qualitative analyzes of cardiamide and lactic acid. 4

Lab 10 Unguentum undecylenicum – isolation of the biologically active

components from the ointment form of a drug. 4

Lab 11 Unguentum undecylenicum – qualitative and quantitative analyzes of

undecylenic acid and its zinc salt form. 4

Lab 12 Ibuprophen – a suspension form of a drug – isolation techniques,

qualitative and quantitative analyzes. 4

Lab 13 Guaiaphenezin – Wiliamson ether synthesis from guaiacol – a component

of suspensions and tablets. Isolation of guaiaphenezin from a tablet. 4

Lab 14 The comparison of qualitative and quantitative analyzes results of

guaiaphenezin isolated from tablet mass with this synthesized. 4

Lab 15 Analyzes of NMR, FT-IR and MS spectra of the isolated biologically

active components of drugs during labs meetings. Repeating of the not

successful realized experiments. 4

Total hours 60

TEACHING TOOLS USED

N1 Lecture with multimedial presentation.

N2 Experiment realizing.

N3 Report preparation.


Evaluation


semester),

P – concluding (at

semester end)

Educational effect


achievement

P1 PEK_W01– W02 The exam

F1(laboratory) PEK_U01 – U05 Completed 9 reports, containing results ,

176

calculations and conclusions, prepared

according to good laboratory practice rules

F2 (laboratory) PEK_U06 NMR, FT-IR and MS spectra analyzes of

every of the biologically active components

isolated by a student during laboratory

meetings (13 completed analyzes).

P2 (laboratory)=(F1 + F2) / 2


PRIMARY LITERATURE:

[70] Partick, Graham, An introduction to medicinal chemistry

[71] Farrell Susan, Principles of Pharmacology

[72] Moynihan, Humphrey A. The physicochemical basic of pharmaceuticals.

[73] R Gancarz, Synthetic organic drug. Script for Medicinal Chemistry – Politechnika

Wrocławska, 2011.

[74] I Pawlaczyk, R Gancarz, Synthetic organic drugs. Labotaroty. Drugs analysis. Script

for Medicinal Chemistry – Politechnika Wrocławska, 2011.

[75] AC Moffat, MD Osselton, B Widdop, Clarke's analysis of drugs and poisons.

Pharmaceutical Press, 2005.


[51] Testa Berbnard, The biochemistry of drug metabolism

[52] Donald J. Abraham, Burgers Medicinal Chemistry and Drug Discovery vol 1-6

[53] Collen Smith, and co. Marks’ Basic Medical Biochemistry A Clinical Approach

[54] Farmakopea Polska V, Urząd Rejestracji Leków, Wyrobów Medycznych I Produktów

Biobójczych, Warszawa, 1990.

[55] M Gorczycowa, A Zejc, Ćwiczenia z chemii leków, praca zbiorowa. Collegium

Medicum UJ, Kraków, 1996.

[56] R Kasprzykowska, AS Kołodziejczyk, Chemiczna analiza środków leczniczych (leki

proste). Skrypt z chemii leków. Uniwersytet Gdański, Gdańsk, 2010.

SUBJECT SUPERVISOR


Roman Gancarz, [email protected]

177


FOR SUBJECT

Synthetic Organic Drugs


Medicinal Chemistry

Subject

educational

effect





Subject



number***

PEK_W01 S2Ach4-W01 C1,C2 Lec1-Lec8 N1

PEK_W02 S2Ach4-W01 C1,C2 Lec9-Lec12 N1

PEK_W03 S2Ach4-W01 C1,C2,C3 Lec13-Lec15 N1


Lab1, Lab4,

Lab5, Lab7,

Lab9, Lab10,

Lab12, Lab13

N1


Lab1, Lab2,

Lab3, Lab4,

Lab6, Lab8,

Lab9, Lab11,

Lab12, Lab14,

Lab15

N2, N3


Lab2, Lab3,

Lab4, Lab6,

Lab8, Lab9,

Lab11, Lab12,

Lab14

N2, N3

PEK_U04 S2Ach4_U01 C4, C5 Lab13, Lab14 N2, N3 PEK_U05 S2Ach4_U01 C4, C5 Lab1 – Lab15 N2, N3


Lab1, Lab2,

Lab3, Lab4,

Lab6, Lab8,

Lab9, Lab11,

Lab12, Lab14,

Lab15

N3



178

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish Techniki syntezy związków organicznych;

operacje jednostkowe

Name in English Techniques of organic syntheses – basic

operations Main field of study (if applicable) Chemia

Specialization (if applicable) Chemia związków organicznych i polimerów






Number of hours of





Form of crediting Examination

crediting

with grade

crediting

with grade


(X) final course


points for practical (P) classes 4 1



student contact (BK) classes 0.8 0.5 0.5



COMPETENCES

1. Acquired knowledge from the field of expanded organic chemistry

2. Knowledge of different types of reactions and their mechanisms

3. Mastered the basic operations and laboratory techniques

SUBJECT OBJECTIVES

C1 familiarize students with various reagents to enable selective transformation of

major functional groups and methods of construction of the carbon skeleton

C2 the modern methods of oxidation and reduction

C3 show the applications of organometallic compounds in the synthesis

C4 discussion of the methods of asymmetric synthesis; the use of catalytic reactions

C5 main protecting groups: their introduction and deleting after the desired

transformation

179



PEK_W01 – knows the Selective method of reduction and oxidation and other functional

group transformations

PEK_W02 – Familiar with the classic and current methods for creating new C-C bonds and,

in particular, the use of carboanions as well as catalytic methods.

PEK_W03 – understands the problem of stereoselectivity and the protection of functional

groups in the multistep synthesis

Relating to skills:

PEK_U01 – Know how to use the retrosynthesis to design a synthesis of complex

molecules.

PEK_U02 – Can propose reagents to perform the planned unit transformations; uses

stereoselective reactions.

PEK_U03 – Can plan and perform selective functional group interconversion and the

creation of new C-C bonds.

PEK_U04 – Has the practical ability to choose protective groups for reaction conditions.

PEK_U05 – Know how to design and execute a multistep synthesis of target organic

compound.

PROGRAMME CONTENT


Lec1 Selective functional group interconversions: the chemo-, regio-and

stereoselective transformation 2

Lec2 Reactions and reactants for selective oxidation of hydrocarbons;

dihydroxylation 4

Lec3 Selective oxidation of alcohols. 2

Lec4 Selective oxidation of sulfides 2

Lec5 Selective catalytic reduction reactions. 4

Lec6 Reduction with metal hydrides 2

Lec7 Classical methods of construction and new carbon-carbon bonds

using organometallic reactions. 4

Lec8 Asymmetric synthesis using catalytic methods 4

Lec9 The use of organo-sulfur and organo-selenium compounds in the

synthesis. 2

Lec10 The use of the organophosphorus derivatives in the synthesis. 2

Lec11 Protection of function groups. 2

Total hours 30

Form of classes - laboratory Number of

hours

La1 First, the theoretical preparation and then the practical perform 4

180

La2 multistep synthesis of complex product using known methods of

carbon skeleton expansion, cyclization, selective functional group

transformation (oxidation, reduction) - depending on the structure of

targeted molecule. If necessary, application of the protecting groups

in the synthesis and available catalytic methods for the synthesis of

enantiomeric compound. Purification, identification and

characterization of the products. Interpretation of the results; the

report.

4

La3 4

La4 4

La5 4

La6 4

La7 4

La8 4

La9 4

La10 4

La11 4

La12 4

La13 4

La14 4

La15 4

Total hours 60

Form of classes - seminar Number of

hours

Se1

Individual preparation and presentation of the different

methodologies (including catalytic) used in the modern synthesis:

selective oxidation, reduction, construction of new C-C bonds,

asymmetric synthesis, etc., based on the current scientific literature.

2

Se2 2

Se3 2

Se4 2

Se5 2

Se6 2

Se7 2

Se8 1

Total hours 15

TEACHING TOOLS USED

N1 Lecture with a multimedia presentation

N2 examples of problem-solving methods, derived from the original literature

N3 discussions on how to solve the problems they have received to prepare ; students-

presentation in a seminar

N5 planning and perform experiments

N6 Detailed documentation of experiments - taking notes (daily laboratory / reports)


Evaluation


semester),


semester end)

Educational effect


achievement

C (laboratory) PEK_U01 –

PEK_U05

evaluation on the basis of proper

preparation, execution and results

zdokumentowania each selected syntheses

181

C (seminar) PEK_U01 –

PEK_U04 evaluation on basis of a presentation of

current methods used in the synthesis based

on the current scientific literature (paper)

C (lecture) PEK_W01 –

PEK_W03

oral test of knowledge of the expansion of

carbon skeletons, selective functional group

transformation (oxidation, reduction) and

their protection, and presented in a lecture

catalytic methods.


PRIMARY LITERATURE:

[76] J. Skarżewski, Wprowadzenie do syntezy organicznej, PWN, Warszawa, 1999.

[77] P. Wyatt, S. Warren, Organic Synthesis, Strategy and Control, J. Wiley, 2007.

[78] S. Warren, Organic Synthesis, The Disconnection Approach, J. Wiley, 1984.

[79] J. Gawroński, K. Gawrońska, K. Kacprzak, M. Kwit, Współczesna Synteza

Organiczna, PWN, Warszawa, 2004.

[80] J. Clayden, N. Greeves, S. Warren, P. Wothers, Organic Chemistry, Oxford University

Press, 2001.

[81] H. O. House, Modern synthetic reactions, A.W. Benjamin ed. 1972

Database: Beilstein, Chemical Abstracts, Current Contents and the current scientific

literature.


[57] J. Clayden, N. Greeves, S. Warren, P. Wothers, Organic Chemistry, Oxford, 2000;

[58] W. Carruthers, I. Coldham, Modern Methods of Organic Synthesis, Cambridge

University Press, 2004.

[59] C. L. Willis, M. Wills, Organic Synthesis, Oxford University Press, 1995;

[60] R. K. Mackie, D. M. Smith, R. A. Aitken, Guidebook to Organic Synthesis, Longman,

1999.

[61] C. L. Willis, M. Wills, Organic Synthesis, Oxford University Press, 1995.

[62] J. H. Fuhrhop, G. Penzlin, .Organic Synthesis, Verlag Chemie, Berlin, 1983

[63] L.-T. Ho, Tactics of Organic Synthesis, J. Wiley, New York, 1994

SUBJECT SUPERVISOR


Dr Przemysław Boratyński, [email protected]

Dr inż. Rafał Kowalczyk, rafał[email protected]

Dr inż. Renata Siedlecka, [email protected]

182


FOR SUBJECT

Techniki syntezy związków organicznych; operacje jednostkowe


Chemia

Chemia związków organicznych i polimerów

Subject

educational

effect





Subject



number***

(knowledge)

PEK_W01 S2Ach3_W01 C1-C2

Lec1-Lec6,

Se1-Se8 N1, N2

PEK_W02 S2Ach3_W01 C3-C5 Lec7, Lec9-

Lec11, Se1-Se8 N1, N2, N3

PEK_W03 S2Ach3_W01 C4 Lec8, Se1-Se8 N1, N2, N3

(skills)

PEK_U01 S2Ach3_U01, S2Ach3_U06 C1, C3, C5 La1-La15 N4-N6

PEK_U02 S2Ach3_U01, S2Ach3_U06 C1-C3 Se1-Se8, La1-

La15 N2-N6

PEK_U03 S2Ach3_U01, S2Ach3_U06 C1, C3, C5 Se1-Se8, La1-

La15 N2-N6

PEK_U04 S2Ach3_U01, S2Ach3_U06 C5 Se1-Se8, La1-

La15 N5, N6

PEK_U05 S2Ach3_U01, S2Ach3_U06 C1-C5 La1-La15 N5, N6



183

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SUBJECT CARD

Name in Polish Techniki reakcji na stałych nośnikach i synteza

kombinatoryczna

Name in English Techniques of solid supported reactions

and combinatorial synthesis Main field of study (if applicable) Chemistry

Specialization (if applicable) Organic and Polymer Chemistry






Number of hours of


University (ZZU) 15




with grade


(X) final course








COMPETENCES

37. Knowledge of organic chemistry corresponding to completion of “Fundamentals of

Organic Chemistry” course.

SUBJECT OBJECTIVES

C1 Knowledge of techniques and methods for the synthesis of organic compounds on a

solid support.

C2 Knowledge of solid support application for the synthesis of selected low molecular

weight compounds and oligomers.

C3 Presentation of combinatorial methodologies leading to combinatorial libraries,

employed for the development of compounds of targeted properties.

184




PEK_W01 – knows theoretical and practical aspects of application of solid supports in

organic synthesis,

PEK_W02 – understand the function of linkers, strategies of immobilization of substrates,

reagents and catalysts, and the cleavage of products,

PEK_W03 – knows techniques and examples for the synthetic preparation of low molecular

weight molecules, natural oligomers and combinatorial libraries of targeted

properties,

PEK_W04 – got to known instrumental techniques used in the synthesis and analysis of the

products.

PROGRAMME CONTENT


Lec 1 Fundamental concepts. Polymer resins, synthesis and structure.

Solid and soluble supports. Inorganic supports. Linkers and spacers

used in organic chemistry on a solid support, structure and function.

Products cleavage strategy.

2

Lec 2 Immobilized reagents and catalysts, obtaining and application in

organic chemistry. Selected types of reactions on a solid support.

Carbon-heteroatom bonds formation. Nucleophilic substitution.

2

Lec 3 Carbon-carbon bonds formation. Electrophilic substitution. Cross-

coupling reactions. The synthesis of heterocyclic compounds on a

solid support. Multicomponent reactions. Isonitriles. Passerini and

Ugi condensation.

2

Lec 4 The synthesis of peptides on a solid support. Protecting groups,

coupling agents. Advantages of immobilization. Flow synthesis.

Oligonucleotides. The synthesis of oligosaccharides on a solid

support.

2

Lec 5 Combinatorial libraries and their types, fundamental concepts.

Preparation by coupling of isokinetic mixtures and "mix and split"

method. Indexed libraries.

2

Lec 6 Selected examples of libraries of low molecular weight compounds

and oligomers. 2

Lec 7 Methods of deconvolution of combinatorial libraries. Isolation and

determination of the structure of the active component. Instrumental

techniques. Tags. Encoded libraries.

2

Lec 8 Instrumentation and automation of the synthesis. Analytical

techniques in the characterization of immobilized products. 1

Total hours 15

TEACHING TOOLS USED

N1 lecture with multimedia presentation

185


Evaluation


semester),


semester end)


achievement

C PEK_W01 – PEK_W04 multimedia presentation


PRIMARY LITERATURE:

[82] F. Z. Dörwald, Organic Synthesis on Solid Phase: Supports, Linkers, Reactions,

Wiley, 2002.

[83] A. Furka, Combinatorial Chemistry. Principles and Techniques,

http://members.iif.hu/furka.arpad/BookPDF.pdf


[64] A. W. Czarnik, Solid-Phase Organic Syntheses (Ed.); Wiley, 2001.

SUBJECT SUPERVISOR




FOR SUBJECT

Techniques of solid supported reactions and combinatorial synthesis



Subject

educational

effect





Subject



number***

(knowledge)

PEK_W01 S2Ach3_W03 C1 – C3 Lec 1 – Lec 6 N1

PEK_W02 S2Ach3_W03 C1 Lec 1, Lec 4,

Lec 7 N1

PEK_W03 S2Ach3_W03 C2, C3 Lec 2 – Lec 7 N1

PEK_W04 S2Ach3_W03 C1 Lec 7, Lec 8 N1



186

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish Chemia Teoretyczna

Name in English Theoretical Chemistry Main field of study (if applicable) Chemistry







Number of hours of







with grade


(X) final course


points for practical (P) classes 1 2



student contact (BK) classes 1 0.5 1



COMPETENCES

38. General Chemistry, Physics I and II

39. Algebra, Mathematical Analysis

40. Ohysical Chemistry, Introduction to Quantum-Chemistry

SUBJECT OBJECTIVES

C1 Introduction to basic concepts of atoms and molecules.

C2 The skills for predicting structure of molecular systems basing on quantum-

chemical methods.

C3 The theoretical interpretation of thermodynamical and electronic properties of

molecules and ions.

C4 The ability to make molecular modeling.

187



PEK_W01 – the understanding of problems and shortcomings of classical physics in the

microscopic description,

PEK_W02 – the knowledge of quantum mechanical postulates and elements of operator

mathematics,

PEK_W03 – the ability to construct of Schrödinger equation (SE) for selected physical

problems and for any molecular system,

PEK_W04 – the understanding of SE for hydrogen atom and the interpretation of equation

solution,

PEK_W05 – the understanding of atomic structure,

PEK_W06 – the basic knowledge of molecular orbital theory,

PEK_W07 – the understanding of the theory of hybrid orbitals, mesomeric concept, and the

idea of multi-center bonds,

PEK_W08 – the knowledge of procedures to solve Hartree-Fock equations and the

correlation energy,

PEK_W09 – the understanding of molecular interactions.

Relating to skills:

PEK_U01 – is able to practical apply data from periodic system of elements,

PEK_U02 – knows the interpretation of electronic spectra of hydrogen atom and heavy

atoms,

PEK_U03 – the ability to predict molecular structure of organic and inorganic molecules,

PEK_U04 – the ability to interpret of spectroscopic data with regard to quantum-chemical

calculations,

PEK_UO5 – the ability to study chemical reaction mechanisms.

PROGRAMME CONTENT


Lec 1 Classical and quantum mechanics. Mathematical bases of

probability theory. Experimental base for wave-corpuscular dualism.

The development of quantum concept with elements of Bohr theory

and reasons for its collapse.

2

Lec 2 The foundations of quantum mechanics. Postulates of quantum

mechanics. The definition of wavefunction and its probabilistic

interpretation. The definition of operators representing observables.

2

Lec 3 The foundations of quantum mechanics II. Schrödinger equation.

Eigenvalues and eigenfunctions of Schrödinger equation. Mean

values of observables. Properties of eigenfunctions in the case of

Schrödinger equation without time.

2

Lec 4 Hydrogen atom. Schrödinger equation for hydrogen and hydrogen-

like cations. The solution with regard energies and wavefunction.

Geometric properties of hydrogen-like orbitals. Quantum numbers.

Energy levels and emission spectra of hydrogen.

2

Lec 5 Pauli exclusion. Electron spin. Multiplicity of many-electron system. 2

188

Electronic states of atoms (atomic terms). Fermions and bosons. The

concept of spinorbital. Pauli exclusion principle. Slater determinant.

Electronic configuration. The structure of periodic system of

elements. Hundt’s rules.

Lec 6 Many-electron atom. Hamiltonian and Schrödinger equation for

many-electron atom. Slater determinant. Wavefunctions for many

electron atoms. Single-electron approximation – spinorbitals and

orbitals. Pauli exclusion principle as an antysymmetric function.

2

Lec 7 Hartree-Fock equations. The energy expression in single electron

approximation. The derivation of Hartree-Fock equations. One and

two electron integrals. Exchange energy. Closed and open-shell

electronic configuration. The selection rules for optical transition.

2

Lec 8 Molecule. Born-Oppenheimer approximation. Schrödinger equation

for molecules. Molecular orbital theory. Linear combination of

molecular orbitals concept. Hartree-Fock-Roothaan-Hall equations.

Thae atomic basis set. Slater and Gaussian functions.

2

Lec 9 Chemical bond. Electrostatic and covalent character of chemical

bonds. Type of bonds. Orbitals σ and π. Bonding, antybonding, and

nonbonding orbitals – energies and geometrical representation. The

electronic structure of diatomic molecules. The bond order.

2

Lec

10

Localized orbitals. Hybridization sp3, sp

2 and sp. The representation

of electronic density in molecules. Localized orbitals as a tool for the

structure prediction. The molecular structure of moieties including

phosphorous. The concept of mesomeric representation. Multicenter

bonds.

2

Lec

11

Molecular spectroscopy I. The rotation and vibration separation.

Rotational spectra of diatomic molecules and elements of microwave

spectroscopy. The selection rules.

2

Lec

12

Molecular spectroscopy II. Vibarational spectra of diatomic and

many-atoms molecules. IR and Raman spectra. The selection rules. 2

Lec

13

Molecular properties based on energy. Ionization energy, electron

affinity. Thermodynamics of chemical processes. Mass spectrometry.

The transition state theory. Reaction mechanism.

2

Lec

14

Properties of molecules based on wavefunction. Electronic density

in the molecule. The bond order. Charge distribution in molecules.

Dipole and higher moments in molecules.

2

Lec

15

Molecular interactions. The theory of molecular interactions.

Electrostatic, exchange, induction, dispersion interactions. Charge-

transfer complexes. Hydrogen bond. The second order structure of

molecular complexes. Conformational analysis.

2

Total hours 30


Cl 1 Organization of classes. Problems with experiment interpretation in

classical mechanics and the Born of quantum theory. 2

Cl 2 Operator mathematics. The properties of operators. The Schrödinger

equation. 2

Cl 3 The solution of simple quantum mechanical problems: potential well and 2

189

particle in the box. Related chemical problems. Rotor and oscillator

models. The elements of spectroscopy.

Cl 4 Hydrogen-like orbitals. Space properties of s, p, d orbitals. Unitary

transformation of orbitals. The radial and angular picture of orbitals.The

studies of untysymmetric properties of function. 2

Cl 5 Hybridization model. The prediction of molecular structure. 2

Cl 6 Energetical and electronic properties of molecules. 2

Cl 7 Calculations of molecular interactions. Atonic charge distribution. Dipole

moment and polarizability. 2

Cl 8 Review and Test. 1

Total hours 15

Form of classes - laboratory Liczba

godzin

La1 The local lab and the computing center organization. Accounts

distribution and basic information about systems.

2

La2 Elements of UNIX (commends). 2

La3 Elements of UNIX (editors). 2

La4 Gaussian-90 program structure. Execution of the program. 2

La5 The structure representation, matrix-Z. 2

La6 The Hartree-Fock calculations. The output file structure. 2

La7 Molecular graphics program – Molden. 2

La8 Structure optimizations. 2

La9 Frequencies, thermochemistry, and vibrational spectra. 2

La10 Project I – structure and properties of molecule. 2

La11 Energetics of chemical reaction. 2

La12 Project II – frequency calculations, spectra simulation. 2

La13 Heat of reaction, synthesis reaction, atomic charge distribution. 2

La14 Project III – the reaction mechanism. 2

La15 Transition state. Molecular interactions. 2

Total houres 30

TEACHING TOOLS USED

N1 Lecture

N2 Problems solving

N3 Project preparation


Evaluation


semester),


semester end)

Educational effect


achievement

C PEK_Lec01-

PEK_Lec15

Final exam

190

F1 PEK_Cl01-

PEK_Cl08

Electronic test

F2 PEK_La1-

PEK_La15

Projects


PRIMARY LITERATURE:

[84] W. Kołos, J. Sadlej, Atom i Cząsteczka, WNT, Warszawa, 1998.

[85] Mechanika Kwantowa dla Chemików, D. O. Hayward, PWN, Warszawa, 2007.

[86] M. A. Ratner, G. C. Schatz, Introduction to Quantum Mechanics in Chemistry,

Prentience Hall, Upper Saddle River, 2001.

[87] Gausisian-90 – Electronic manual.


[65] L. Piela, Idee Chemii Kwantowej, PWN, Warszawa, 2010.

[66] W. Kołos, Chemia Kwantowa, PWN, Warszawa, 1975.

[67] K. Pigoń, Z. Ruziewicz, Chemia Fizyczna (cz. 2), PWN, Warszawa, 2005.

[68] System elektronicznych korepetycji (e – learning).

SUBJECT SUPERVISOR


Szczepan Roszak, [email protected]


FOR SUBJECT

Theoretical Chemistry


Chemistry

Subject

educational

effects





Subject

objectives

***

Programme

content***

Teaching too

number***

(knowladge)

PEK_W01

K2Ach_W02, K2Ach_W03,

S2Ach1_W06, S2Ach4_W06 C1 Wy1 N1

PEK_W02 K2Ach_W02, K2Ach_W03,

S2Ach1_W06, S2Ach4_W06 C1 Wy3, Wy4 N1




S2Ach1_W06, S2Ach4_W06 C2 Wy5 – Wy9 N1

PEK_W05 K2Ach_W02, K2Ach_W03, C3 Wy10 N1

191

S2Ach1_W06, S2Ach4_W06




S2Ach1_W06, S2Ach4_W06 C3 Wy12 – Wy14 N1



(skills)

PEK_U01

K2Ach_U01, K2Ach_U02,

S2Ach2_U05,S2Ach3_ U05 C4

Ćw1 – Ćw3

La6 - La14 N2, N3

PEK_U02 K2Ach_U01, K2Ach_U02,


Ćw3 – Ćw7

La6 - La14 N2, N3



Ćw1 – Ćw5

La6 - La14 N2, N3



Ćw7

La6 - La14 N2, N3



Ćw7

La6 - La14 N2, N3



192

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish: Analiza termiczna i kalorymetria

Name in English: Thermal analysis and calorimetry

Main field of study (if applicable): Chemistry



level, full-time





Number of hours of


University (ZZU) 30




with grade


(X) final course









SUBJECT OBJECTIVES

C1 Familiarization students with definition, range and limits and nomenclature of

thermal analysis

C2 Acquainting students with thermogravimetry

C3 Familiarization students with differential thermal analysis (DTA).

C4 Familiarization students with phase diagrams construction on the basis of Dta and

DSC measurements

C5 Acquainting students with thermomechanica analysis ™ and evolved gas analysis

C6 Familiarization students with coupling methods in thermal analysis

C7 Familiarization students with application of thermal analysis for studies of inorganic

materials, ceramics, metals, pharmaceutics and polymers.

193



PEK_W01 – knows definition, range and limits and nomenclature of thermal analysis,

PEK_W02 – knows apparatus, calibration procedure and working conditions, interpretations

of curves and sources of error,

PEK_W03 – knows basic theory, apparatus used and way of results interpretation,

PEK_W04 – knows how to use results of DTA or DSC measurements for construction of

phase diagram,

PEK_W05 – knows theoretical background and instrumentation of thermomechanical

analysis and evolved gas analysis,

PEK_W06 – has basic knowledge concerning coupling methods: TG-DTA, TG-DTA/DSC-

MS, TG-FTIR, TG-GC-MS,

PEK_W07 – knows different areas where methods of thermal analysis can be applied.

PROGRAMME CONTENT


Lec1 Introduction, definition, range and limits and nomenclature of

thermal analysis 2

Lec2 Classification, names and definitions of thermoanalytical methods 2

Lec3 Thermogravimetry (TGA) – apparatus, calibration, sources of

error 2

Lec4 TGA: optimal working conditions, TG, DTG curves and their

interpretation 2

Lec5 Differential thermal analysis (DTA) – apparatus, calibration,

sources of error 2

Lec6 Differential scanning calorimetry (DSC) - apparatus, calibration,

sources of error 2

Lec7 DTA/DSC curves, their characteristics, comparison and

interpretation 2

Lec8 Heat reactions determination by DSC 2

Lec9 Phase diagrams construction by DSC curves 4

Lec10 Thermomechanical methods (TMA) - review of methods,

instrumentation, applications 2

Lec11 Evolved gas analysis (EGA) – methods, instrumentation examples

of applications 2

Lec12 Coupling methods: TG-DTA, TG-DTA/DSC-MS, TG-FTIR, TG-

GC-MS 2

Lec13 Examples of TA applications to studies of inorganic materials,

ceramics and metals 2

Lec14 Examples of TA applications to studies of polymers,

pharmaceuticals and foods. 2

Total hours 30

194

TEACHING TOOLS USED



Evaluation


semester),


semester end)


achievement



PRIMARY LITERATURE:

[1]. J.W. Dodd, K.H. Tonge, Thermal methods, ACOL, J. Wiley &Sons, Chichester, New

York, Brisbane, Toronto, Singapure, 1987;

[2]. M.E. Brown (ED, Handbook of Thermal Analysis and Calorimetry, vol.1, Principles and

Practice, Elsevier, Amsterdam 1998.


[1]. E.L. Charsley, S.B. Warrington (Eds.),Thermal Analysis – Techniques& Applications,

The Royal Society of Chemistry, Cambridge, 1992;.

[2]. , F. Paulik, Special Trends in Thermal Analysis, J. Wiley & Sons, Chichester, 1995

[3]. W. W. Wendlandt, Thermal Analysis, J. Wiley & Sons, New York, Brisbane, Toronto,

Singapure,1986

SUBJECT SUPERVISOR




FOR SUBJECT

Thermal analysis and calorimetry


Chemistry

Subject





Subject



number***

(knowledge)

PEK_W01 Optional C1 Lec1-Lec2 N1

195





PEK_W06 C6 Lec12 N1




196

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish: Metalurgia metali nieżelaznych

Name in English: Waste materials in metallurgy

Main field of study (if applicable): Chemistry



level, full-time





Number of hours of


University (ZZU) 15




with grade


(X) final course









SUBJECT OBJECTIVES

C1 Familiarization students with sources and types of wastes generated in metallurgy

C2 Acquainting students with properties and utilization of waste from metallurgical

processes

C3 Familiarization students with metallurgical recovery of metal-bearing and non-metal

bearing wastes.

197



PEK_W01 – knows sources and types of wastes that are produced by metallurgy,

PEK_W02 – knows basic properties of wastes and ways of their utilization,

PEK_W03 – knows unit processes used in metallurgical recovery of metal-bearing and non-

metal bearing wastes.

PROGRAMME CONTENT


Lec1 Metallurgical process as a source of waste 2

Lec2 Slag (and solid waste) 2

Lec3 Dust (fly ashes) 2

Lec4 Fumes and gases 2

Lec5 Waste waters and sludges 2

Lec6 Waste recovery in metallurgical operations 2

Lec7 Scarp and metal-bearing waste 2

Lec8 Non-metal bearing waste processing 1

Total hours 15

TEACHING TOOLS USED



Evaluation


semester),


semester end)


achievement


198


PRIMARY LITERATURE:

[1]. S. Ramachandra Rao, Resource, recovery and recycling from metallurgical wastes,

Elsevier B.V. 2006



SUBJECT SUPERVISOR




FOR SUBJECT

Waste materials in metallurgy


Chemistry

Subject





Subject



number***

(knowledge)






199

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish: Analiza termiczna i kalorymetria

Name in English: Thermal analysis and calorimetry Main field of study (if applicable): Chemistry



level, full-time





Number of hours of


University (ZZU) 30




with grade


(X) final course









SUBJECT OBJECTIVES

C1 Familiarization students with definition, range and limits and nomenclature of

thermal analysis

C2 Acquainting students with thermogravimetry

C3 Familiarization students with differential thermal analysis (DTA).

C4 Familiarization students with phase diagrams construction on the basis of Dta and

DSC measurements

C5 Acquainting students with thermomechanica analysis ™ and evolved gas analysis

C6 Familiarization students with coupling methods in thermal analysis

C7 Familiarization students with application of thermal analysis for studies of inorganic

materials, ceramics, metals, pharmaceutics and polymers.

200



PEK_W01 – knows definition, range and limits and nomenclature of thermal analysis,

PEK_W02 – knows apparatus, calibration procedure and working conditions, interpretations

of curves and sources of error,

PEK_W03 – knows basic theory, apparatus used and way of results interpretation,

PEK_W04 – knows how to use results of DTA or DSC measurements for construction of

phase diagram,

PEK_W05 – knows theoretical background and instrumentation of thermomechanical

analysis and evolved gas analysis,

PEK_W06 – has basic knowledge concerning coupling methods: TG-DTA, TG-DTA/DSC-

MS, TG-FTIR, TG-GC-MS,

PEK_W07 – knows different areas where methods of thermal analysis can be applied.

PROGRAMME CONTENT


Lec1 Introduction, definition, range and limits and nomenclature of

thermal analysis 2

Lec2 Classification, names and definitions of thermoanalytical methods 2

Lec3 Thermogravimetry (TGA) – apparatus, calibration, sources of

error 2

Lec4 TGA: optimal working conditions, TG, DTG curves and their

interpretation 2

Lec5 Differential thermal analysis (DTA) – apparatus, calibration,

sources of error 2

Lec6 Differential scanning calorimetry (DSC) - apparatus, calibration,

sources of error 2

Lec7 DTA/DSC curves, their characteristics, comparison and

interpretation 2

Lec8 Heat reactions determination by DSC 2

Lec9 Phase diagrams construction by DSC curves 4

Lec10 Thermomechanical methods (TMA) - review of methods,

instrumentation, applications 2

Lec11 Evolved gas analysis (EGA) – methods, instrumentation examples

of applications 2

Lec12 Coupling methods: TG-DTA, TG-DTA/DSC-MS, TG-FTIR, TG-

GC-MS 2

Lec13 Examples of TA applications to studies of inorganic materials,

ceramics and metals 2

Lec14 Examples of TA applications to studies of polymers,

pharmaceuticals and foods. 2

Total hours 30

201

TEACHING TOOLS USED



Evaluation


semester),


semester end)


achievement



PRIMARY LITERATURE:

[1]. J.W. Dodd, K.H. Tonge, Thermal methods, ACOL, J. Wiley &Sons, Chichester, New

York, Brisbane, Toronto, Singapure, 1987;

[2]. M.E. Brown (ED, Handbook of Thermal Analysis and Calorimetry, vol.1, Principles and

Practice, Elsevier, Amsterdam 1998.


[1]. E.L. Charsley, S.B. Warrington (Eds.),Thermal Analysis – Techniques& Applications,

The Royal Society of Chemistry, Cambridge, 1992;.

[2]. , F. Paulik, Special Trends in Thermal Analysis, J. Wiley & Sons, Chichester, 1995

[3]. W. W. Wendlandt, Thermal Analysis, J. Wiley & Sons, New York, Brisbane, Toronto,

Singapure,1986

SUBJECT SUPERVISOR



202


FOR SUBJECT

Thermal analysis and calorimetry


Chemistry

Subject





Subject



number***

(knowledge)

PEK_W01

Optional

C1 Lec1-Lec2 N1





PEK_W06 C6 Lec12 N1




203

Zał. nr 4 do ZW 64/2012



SUBJECT CARD

Name in Polish: Metalurgia metali nieżelaznych

Name in English: Waste materials in metallurgy Main field of study (if applicable): Chemistry



level, full-time





Number of hours of


University (ZZU) 15




with grade


(X) final course









SUBJECT OBJECTIVES

C1 Familiarization students with sources and types of wastes generated in metallurgy

C2 Acquainting students with properties and utilization of waste from metallurgical

processes

C3 Familiarization students with metallurgical recovery of metal-bearing and non-metal

bearing wastes.

204



PEK_W01 – knows sources and types of wastes that are produced by metallurgy,

PEK_W02 – knows basic properties of wastes and ways of their utilization,

PEK_W03 – knows unit processes used in metallurgical recovery of metal-bearing and non-

metal bearing wastes.

PROGRAMME CONTENT


Lec1 Metallurgical process as a source of waste 2

Lec2 Slag (and solid waste) 2

Lec3 Dust (fly ashes) 2

Lec4 Fumes and gases 2

Lec5 Waste waters and sludges 2

Lec6 Waste recovery in metallurgical operations 2

Lec7 Scarp and metal-bearing waste 2

Lec8 Non-metal bearing waste processing 1

Total hours 15

TEACHING TOOLS USED



Evaluation


semester),


semester end)


achievement


205


PRIMARY LITERATURE:

[1]. S. Ramachandra Rao, Resource, recovery and recycling from metallurgical wastes,

Elsevier B.V. 2006



SUBJECT SUPERVISOR




FOR SUBJECT

Waste materials in metallurgy


Chemistry

Subject





Subject



number***

(knowledge)






1 Advanced methods of identification of organic compounds ...

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