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- PublicationsLife & Medical Sciences Institute

LIMES

2021

Aamer W, Hassan HY, Nakaoka H, Hosomichi K, Jaeger M, Tahir H, Abdelraheem MH, Netea MG, Inoue I. Analysis of HLA gene polymorphisms in East Africans reveals evidence of gene flow in two Semitic populations from Sudan. Eur J Hum Genet. 2021 Mar 22. doi: 10.1038/s41431-021-00845-6. Online ahead of print. PMID: 33753913

Akoumianaki T, Vaporidi K, Diamantaki E, Pène F, Beau R, Gresnigt MS, Gkountzinopulou M, Venichaki M, Drakos E, El-Benna J, Samonis G, Le KTT, Kumar V, Georgopoulos D, van de Veerdonk FL, Netea MG, Latge JP, Chamilos G. Uncoupling of IL-6 signaling and LC3-associated phagocytosis drives im-munoparalysis during sepsis. Cell Host Microbe. 2021 Aug 11;29(8):1277-1293.e6. doi: 10.1016/j.chom.2021.06.002. Epub 2021 Jul 1. PMID: 34214493

Angelidou A, Diray-Arce J, Conti MG, Netea MG, Blok BA, Liu M, Sanchez-Schmitz G, Ozonoff A, van Haren SD, Levy O. Human Newborn Monocytes Demonstrate Distinct BCG-Induced Primary and Trained Innate Cytokine Production and Metabolic Activation In Vitro. Front Immunol. 2021 Jul 13;12:674334. doi: 10.3389/fimmu.2021.674334. eCollection 2021. PMID: 34326836 Free PMC ar-ticle.

Aschenbrenner AC, Mouktaroudi M, Krämer B, Oestreich M, Antonakos N, Nuesch-Germano M, Gkizeli K, Bonaguro L, Reusch N, Baßler K, Saridaki M, Knoll R, Pecht T, Kapellos TS, Doulou S, Kröger C, Herbert M, Holsten L, Horne A, Gemünd ID, Rovina N, Agrawal S, Dahm K, van Uelft M, Drews A, Lenkeit L, Bruse N, Gerretsen J, Gierlich J, Becker M, Händler K, Kraut M, Theis H, Mengiste S, De Domenico E, Schulte-Schrepping J, Seep L, Raabe J, Hoffmeister C, ToVinh M, Keitel V, Rieke G, Talevi V, Skowasch D, Aziz NA, Pickkers P, van de Veerdonk FL, Netea MG, Schultze JL, Kox M, Breteler MMB, Nattermann J, Koutsoukou A, Giamarellos-Bourboulis EJ, Ulas T; German COVID-19 Omics Initiative (DeCOI). Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients. Genome Med. 2021 Jan 13;13(1):7. doi: 10.1186/s13073-020-00823-5. PMID: 33441124

Bain JM, Alonso MF, Childers DS, Walls CA, Mackenzie K, Pradhan A, Lewis LE, Louw J, Avelar GM, Lar-combe DE, Netea MG, Gow NAR, Brown GD, Erwig LP, Brown AJP. Immune cells fold and dam-age fungal hyphae. Proc Natl Acad Sci U S A. 2021 Apr 13;118(15):e2020484118. doi: 10.1073/pnas.2020484118. PMID: 33876755 Free PMC article.

Bajorath J. Evolution of assay interference concepts in drug discovery. Expert Opin Drug Discov. 2021 Mar 18:1-3. doi: 10.1080/17460441.2021.1902983. Online ahead of print. PMID: 33733961

Bajorath J. Minimal screening requirements for identifying highly promiscuous kinase inhibitors. Fu-ture Med Chem. 2021 May 17. doi: 10.4155/fmc-2021-0077. Online ahead of print. PMID: 33998280

Bajorath J. State-of-the-art of artificial intelligence in medicinal chemistry. Future Sci OA. 2021 Mar 29;7(6):FSO702. doi: 10.2144/fsoa-2021-0030. PMID: 34046204

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Bajorath J. Comprehensive analysis of R-groups in medicinal chemistry. Future Med Chem. 2022 Jan;14(1):5-7. doi: 10.4155/fmc-2021-0250. Epub 2021 Oct 21. PMID: 34672719 No abstract avail-able.

Baltruschat L, Prisco L, Ranft P, Lauritzen JS, Fiala A, Bock DD, Tavosanis G. Circuit reorganization in the Drosophila mushroom body calyx accompanies memory consolidation. Cell Rep. 2021 Mar 16;34(11):108871. doi: 10.1016/j.celrep.2021.108871. PMID: 33730583

Batool S, Bin-T-Abid D, Batool H, Shahid S, Saleem M, Khan AU, Hamid A, Mahmood MS, Ashraf NM. De-velopment of multi-epitope vaccine constructs for non-small cell lung cancer (NSCLC) against USA human leukocyte antigen background: an immunoinformatic approach toward future vaccine de-signing. Expert Opin Biol Ther. 2021 Nov;21(11):1525-1533. doi: 10.1080/14712598.2021.1981285. Epub 2021 Sep 29. PMID: 34547976

Beckert V, Rassmann S, Kayvanjoo AH, Klausen C, Bonaguro L, Botermann DS, Krause M, Moreth K, Spielmann N, da Silva-Buttkus P, Fuchs H, Gailus-Durner V, de Angelis MH, Händler K, Ulas T, Aschenbrenner AC, Mass E, Wachten D. Creld1 regulates myocardial development and function. J Mol Cell Cardiol. 2021 Mar 24;156:45-56. doi: 10.1016/j.yjmcc.2021.03.008. Online ahead of print. PMID: 33773996

Bejarano DA, Schlitzer A. Breathing more breadth into COVID-19 T cell responses. Med (N Y). 2021 Sep 10;2(9):999-1001. doi: 10.1016/j.medj.2021.08.009. PMID: 34522907 Free PMC article.

Bekkering S, Domínguez-Andrés J, Joosten LAB, Riksen NP, Netea MG. Trained Immunity: Reprogram-ming Innate Immunity in Health and Disease. Annu Rev Immunol. 2021 Apr 26;39:667-693. doi: 10.1146/annurev-immunol-102119-073855. Epub 2021 Feb 26. PMID: 33637018

Berendsen MLT, Smits J, Netea MG, van der Ven A. In response to the Letter to the Editor by Ould Setti and Ould Setti RE: ‘Non-specific Effects of vaccines and stunting: Timing May Be Essential’. EBi-oMedicine. 2021 Nov;73:103606. doi: 10.1016/j.ebiom.2021.103606. Epub 2021 Oct 19. PMID: 34678612 Free PMC article. No abstract available.

Bethlehem L, van Echten-Deckert G. Ectoines as novel anti-inflammatory and tissue protective lead compounds with special focus on inflammatory bowel disease and lung inflammation. Pharmacol Res. 2021 Feb;164:105389. doi: 10.1016/j.phrs.2020.105389. Epub 2020 Dec 19. PMID: 33352226 Review.

Blank N, Mayer M, Mass E. The development and physiological and pathophysiological functions of resident macrophages and glial cells. Adv Immunol. 2021;151:1-47. doi: 10.1016/bs.ai.2021.08.001. Epub 2021 Oct 4. PMID: 34656287

Blaschke T, Feldmann C, Bajorath J. Prediction of Promiscuity Cliffs Using Machine Learning. Mol In-form. 2021 Jan;40(1):e2000196. doi: 10.1002/minf.202000196. Epub 2020 Sep 29. PMID: 32881355

Blaschke T, Bajorath J. Compound dataset and custom code for deep generative multi-target com-pound design. Future Sci OA. 2021 Apr 30;7(6):FSO715. doi: 10.2144/fsoa-2021-0033. PMID: 34046209 Free PMC article.

Blaschke T, Bajorath J. Fine-tuning of a generative neural network for designing multi-target com-pounds. J Comput Aided Mol Des. 2021 May 28. doi: 10.1007/s10822-021-00392-8. Online ahead of print. PMID: 34046745

Boahen CK, Joosten LAB, Netea MG, Kumar V. Conceptualization of population-specific human func-tional immune-genomics projects to identify factors that contribute to variability in immune and infectious diseases. Heliyon. 2021 Apr 13;7(4):e06755. doi: 10.1016/j.heliyon.2021.e06755. eCol-lection 2021 Apr. PMID: 33912719 Free PMC article. Review.

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Bourgeois R, Girard A, Perrot N, Guertin J, Mitchell PL, Couture C, Gotti C, Bourassa S, Poggio P, Mass E, Capoulade R, Scipione CA, Després AA, Couture P, Droit A, Pibarot P, Boffa MB, Thériault S, Koschin-sky ML, Mathieu P, Arsenault BJ. A Comparative Analysis of the Lipoprotein(a) and Low-Density Lipoprotein Proteomic Profiles Combining Mass Spectrometry and Mendelian Randomization. CJC Open. 2020 Dec 3;3(4):450-459. doi: 10.1016/j.cjco.2020.11.019. eCollection 2021 Apr. PMID: 34027348

Brand T, van den Munckhof ICL, van der Graaf M, Schraa K, Dekker HM, Joosten LAB, Netea MG, Rik-sen NP, de Graaf J, Rutten JHW. Superficial vs Deep Subcutaneous Adipose Tissue: Sex-Specific Associations With Hepatic Steatosis and Metabolic Traits. J Clin Endocrinol Metab. 2021 Sep 27;106(10):e3881-e3889. doi: 10.1210/clinem/dgab426. PMID: 34137897

Breiden B, Sandhoff K. Acid Sphingomyelinase, a Lysosomal and Secretory Phospholipase C, Is Key for Cellular Phospholipid Catabolism. Int J Mol Sci. 2021 Aug 20;22(16):9001. doi: 10.3390/ijms22169001. PMID: 34445706 Free PMC article. Review.

Breiden B, Sandhoff K. Corrigendum to: Emerging mechanisms of drug-induced phospholipidosis. Biol Chem. 2021 Oct 27;403(2):251. doi: 10.1515/hsz-2021-0383. PMID: 34706402 No abstract available.

Brouwer MAE, Jones-Warner W, Rahman S, Kerstholt M, Ferreira AV, Oosting M, Hooiveld GJ, Netea MG, Joosten LAB. B. burgdorferi sensu lato-induced inhibition of antigen presentation is mediated by RIP1 signaling resulting in impaired functional T cell responses towards Candida albicans. Ticks Tick Borne Dis. 2021 Mar;12(2):101611. doi: 10.1016/j.ttbdis.2020.101611. Epub 2020 Nov 23. PMID: 33360386

Bruno M, Dewi IMW, Matzaraki V, Ter Horst R, Pekmezovic M, Rösler B, Groh L, Röring RJ, Kumar V, Li Y, Car-valho A, Netea MG, Latgé JP, Gresnigt MS, van de Veerdonk FL. Comparative host transcriptome in response to pathogenic fungi identifies common and species-specific transcriptional antifun-gal host response pathways. Comput Struct Biotechnol J. 2020 Dec 26;19:647-663. doi: 10.1016/j.csbj.2020.12.036. eCollection 2021. PMID: 33510868

Bruno M, Horst R, Pekmezovic M, Kumar V, Li Y, Netea MG, Latgé JP, Gresnigt MS, van de Veerdonk FL. Data of common and species-specific transcriptional host responses to pathogenic fungi. Data Brief. 2021 Mar 4;35:106928. doi: 10.1016/j.dib.2021.106928. eCollection 2021 Apr. PMID: 33850980

Bruno M, Matzaraki V, van de Veerdonk FL, Kumar V, Netea MG. Challenges and opportunities to un-derstanding genetics of fungal diseases: towards a functional genomics approach. Infect Immun. 2021 May 24:IAI.00005-21. doi: 10.1128/IAI.00005-21. Online ahead of print. PMID: 34031131 Re-view.

Cavalli G, Tengesdal IW, Gresnigt M, Nemkov T, Arts RJW, Domínguez-Andrés J, Molteni R, Stefanoni D, Cantoni E, Cassina L, Giugliano S, Schraa K, Mills TS, Pietras EM, Eisenmensser EZ, Dagna L, Boletta A, D’Alessandro A, Joosten LAB, Netea MG, Dinarello CA. The anti-inflammatory cytokine inter-leukin-37 is an inhibitor of trained immunity. Cell Rep. 2021 Apr 6;35(1):108955. doi: 10.1016/j.celrep.2021.108955. PMID: 33826894

Chumakov K, Avidan MS, Benn CS, Bertozzi SM, Blatt L, Chang AY, Jamison DT, Khader SA, Kottilil S, Netea MG, Sparrow A, Gallo RC. Old vaccines for new infections: Exploiting innate immu-nity to control COVID-19 and prevent future pandemics. Proc Natl Acad Sci U S A. 2021 May 25;118(21):e2101718118. doi: 10.1073/pnas.2101718118. PMID: 34006644

Chu X, Jaeger M, Beumer J, Bakker OB, Aguirre-Gamboa R, Oosting M, Smeekens SP, Moorlag S, Mourits VP, Koeken VACM, de Bree C, Jansen T, Mathews IT, Dao K, Najhawan M, Watrous JD, Joosten I, Shar-ma S, Koenen HJPM, Withoff S, Jonkers IH, Netea-Maier RT, Xavier RJ, Franke L, Xu CJ, Joosten LAB, Sanna S, Jain M, Kumar V, Clevers H, Wijmenga C, Netea MG, Li Y. Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease. Genome Biol. 2021 Jul 6;22(1):198. doi: 10.1186/s13059-021-02413-z. PMID: 34229738 Free PMC article.

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Cox N, Crozet L, Holtman IR, Loyher PL, Lazarov T, White JB, Mass E, Stanley ER, Elemento O, Glass CK, Geissmann F. Diet-regulated production of PDGFcc by macrophages controls energy storage. Sci-ence. 2021 Jul 2;373(6550):eabe9383. doi: 10.1126/science.abe9383. PMID: 34210853

Das S, Marin ND, Esaulova E, Ahmed M, Swain A, Rosa BA, Mitreva M, Rangel-Moreno J, Netea MG, Barreiro LB, Divangahi M, Artyomov MN, Kaushal D, Khader SA. Lung Epithelial Signaling Medi-ates Early Vaccine-Induced CD4+ T Cell Activation and Mycobacterium tuberculosis Control. mBio. 2021 Aug 31;12(4):e0146821. doi: 10.1128/mBio.01468-21. Epub 2021 Jul 13. PMID: 34253059 Free PMC article.

Davidson L, van den Reek JMPA, Bruno M, van Hunsel F, Herings RMC, Matzaraki V, Boahen CK, Kumar V, Groenewoud HMM, van de Veerdonk FL, Netea MG, de Jong EMGJ, Kullberg BJ. Risk of candidiasis associated with interleukin-17 inhibitors: A real-world observational study of multiple independ-ent sources. Lancet Reg Health Eur. 2021 Nov 22;13:100266. doi: 10.1016/j.lanepe.2021.100266. eCollection 2022 Feb. PMID: 34950923 Free PMC article.

De Filippis C, Napoli B, Rigon L, Guarato G, Bauer R, Tomanin R, Orso G. Drosophila D-idua Reduction Mimics Mucopolysaccharidosis Type I Disease-Related Phenotypes. Cells. 2021 Dec 31;11(1):129. doi: 10.3390/cells11010129. PMID: 35011691 Free PMC article.

de Graaf DM, Teufel LU, van de Veerdonk FL, Joosten LAB, Netea MG, Dinarello CA, Arts RJW. IL-38 prevents induction of trained immunity by inhibition of mTOR signaling. J Leukoc Biol. 2021 Nov;110(5):907-915. doi: 10.1002/JLB.3A0220-143RRR. Epub 2021 Feb 23. PMID: 33620105 Free PMC article.

Debisarun PA, Gössling KL, Bulut O, Kilic G, Zoodsma M, Liu Z, Oldenburg M, Rüchel N, Zhang B, Xu CJ, Struycken P, Koeken VACM, Domínguez-Andrés J, Moorlag SJCFM, Taks E, Ostermann PN, Müller L, Schaal H, Adams O, Borkhardt A, Ten Oever J, van Crevel R, Li Y, Netea MG. Induction of trained im-munity by influenza vaccination - impact on COVID-19. PLoS Pathog. 2021 Oct 25;17(10):e1009928. doi: 10.1371/journal.ppat.1009928. eCollection 2021 Oct. PMID: 34695164 Free PMC article.

Dewi IM, Janssen NA, Rosati D, Bruno M, Netea MG, Brüggemann RJ, Verweij PE, van de Veerdonk FL. Invasive pulmonary aspergillosis associated with viral pneumonitis. Curr Opin Microbiol. 2021 Aug;62:21-27. doi: 10.1016/j.mib.2021.04.006. Epub 2021 May 23. PMID: 34034082 Review.

DiNardo AR, Netea MG, Musher DM. Postinfectious Epigenetic Immune Modifications - A Double-Edged Sword. N Engl J Med. 2021 Jan 21;384(3):261-270. doi: 10.1056/NEJMra2028358. PMID: 33471978

Divangahi M, Aaby P, Khader SA, Barreiro LB, Bekkering S, Chavakis T, van Crevel R, Curtis N, DiNardo AR, Dominguez-Andres J, Duivenwoorden R, Fanucchi S, Fayad Z, Fuchs E, Hamon M, Jeffrey KL, Khan N, Joosten LAB, Kaufmann E, Latz E, Matarese G, van der Meer JWM, Mhlanga M, Moorlag SJCFM, Mulder WJM, Naik S, Novakovic B, O’Neill L, Ochando J, Ozato K, Riksen NP, Sauerwein R, Sherwood ER, Schlitzer A, Schultze JL, Sieweke MH, Benn CS, Stunnenberg H, Sun J, van de Veerdonk FL, Weis S, Williams DL, Xavier R, Netea MG. Trained immunity, tolerance, priming and differentiation: distinct immunological processes. Nat Immunol. 2021 Jan;22(1):2-6. doi: 10.1038/s41590-020-00845-6. PMID: 33293712 No abstract available.

Divangahi M, Aaby P, Khader SA, Barreiro LB, Bekkering S, Chavakis T, van Crevel R, Curtis N, DiNardo AR, Dominguez-Andres J, Duivenvoorden R, Fanucchi S, Fayad Z, Fuchs E, Hamon M, Jeffrey KL, Khan N, Joosten LAB, Kaufmann E, Latz E, Matarese G, van der Meer JWM, Mhlanga M, Moorlag SJCFM, Mulder WJM, Naik S, Novakovic B, O’Neill L, Ochando J, Ozato K, Riksen NP, Sauerwein R, Sherwood ER, Schlitzer A, Schultze JL, Sieweke MH, Benn CS, Stunnenberg H, Sun J, van de Veerdonk FL, Weis S, Williams DL, Xavier R, Netea MG. Author Correction: Trained immunity, tolerance, priming and differentiation: distinct immunological processes. Nat Immunol. 2021 May 20. doi: 10.1038/s41590-021-00960-y. Online ahead of print. PMID: 34017127 No abstract available.

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Domínguez-Andrés J, Arts RJW, Bekkering S, Bahrar H, Blok BA, de Bree LCJ, Bruno M, Bulut Ö, Debisarun PA, Dijkstra H, Cristina Dos Santos J, Ferreira AV, Flores-Gomez D, Groh LA, Grondman I, Helder L, Jacobs C, Jacobs L, Jansen T, Kilic G, Klück V, Koeken VACM, Lemmers H, Moorlag SJCFM, Mourits VP, van Puffelen JH, Rabold K, Röring RJ, Rosati D, Tercan H, van Tuijl J, Quintin J, van Crevel R, Riksen NP, Joosten LAB, Netea MG. In vitro induction of trained immunity in adherent human monocytes. STAR Protoc. 2021 Feb 24;2(1):100365. doi: 10.1016/j.xpro.2021.100365. eCollection 2021 Mar 19. PMID: 33718890

Domínguez-Andrés J, Kuijpers Y, Bakker OB, Jaeger M, Xu CJ, Van der Meer JW, Jakobsson M, Bertranpetit J, Joosten LA, Li Y, Netea MG. Evolution of cytokine production capacity in ancient and modern European populations. Elife. 2021 Sep 7;10:e64971. doi: 10.7554/eLife.64971. PMID: 34488939 Free PMC article.

Edgar L, Akbar N, Braithwaite AT, Krausgruber T, Gallart-Ayala H, Bailey J, Corbin AL, Khoyratty TE, Chai JT, Alkhalil M, Rendeiro AF, Ziberna K, Arya R, Cahill TJ, Bock C, Laurencikiene J, Crabtree MJ, Le-mieux ME, Riksen NP, Netea MG, Wheelock CE, Channon KM, Rydén M, Udalova IA, Carnicer R, Choudhury RP. Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis. Circulation. 2021 Sep 21;144(12):961-982. doi: 10.1161/CIRCULA-TIONAHA.120.046464. Epub 2021 Jul 13. PMID: 34255973 Free PMC article.

Embgenbroich M, van der Zande HJP, Hussaarts L, Schulte-Schrepping J, Pelgrom LR, García-Tardón N, Schlautmann L, Stoetzel I, Händler K, Lambooij JM, Zawistowska-Deniziak A, Hoving L, de Ruiter K, Wijngaarden M, Pijl H, Willems van Dijk K, Everts B, van Harmelen V, Yazdanbakhsh M, Schultze JL, Guigas B, Burgdorf S. Soluble mannose receptor induces proinflammatory macrophage ac-tivation and metaflammation. Proc Natl Acad Sci U S A. 2021 Aug 3;118(31):e2103304118. doi: 10.1073/pnas.2103304118. PMID: 34326259

Enderes J, Mallesh S, Schneider R, Hupa KJ, Lysson M, Schneiker B, Händler K, Schlotmann B, Günther P, Schultze JL, Kalff JC, Wehner S. A Population of Radio-Resistant Macrophages in the Deep Myen-teric Plexus Contributes to Postoperative Ileus Via Toll-Like Receptor 3 Signaling. Front Immunol. 2021 Jan 13;11:581111. doi: 10.3389/fimmu.2020.581111. eCollection 2020. PMID: 33519804

Edwards-Faret G, González-Pinto K, Cebrián-Silla A, Peñailillo J, García-Verdugo JM, Larraín J. Cellu-lar response to spinal cord injury in regenerative and non-regenerative stages in Xenopus laevis. Neural Dev. 2021 Feb 2;16(1):2. doi: 10.1186/s13064-021-00152-2. PMID: 33526076

Erazo AB, Wang N, Standke L, Semeniuk AD, Fülle L, Cengiz SC, Thiem M, Weighardt H, Strugnell RA, Förster I. CCL17-expressing dendritic cells in the intestine are preferentially infected by Sal-monella but CCL17 plays a redundant role in systemic dissemination. Immun Inflamm Dis. 2021 Sep;9(3):891-904. doi: 10.1002/iid3.445. Epub 2021 May 4. PMID: 33945673 Free PMC article.

Fanucchi S, Domínguez-Andrés J, Joosten LAB, Netea MG, Mhlanga MM. The Intersection of Epigenet-ics and Metabolism in Trained Immunity. Immunity. 2021 Jan 12;54(1):32-43. doi: 10.1016/j.im-muni.2020.10.011. Epub 2020 Nov 20. PMID: 33220235 Review.

Faßbender S, Sondenheimer K, Majora M, Schindler J, Opitz FV, Pollet M, Haarmann-Stemmann T, Krutmann J, Weighardt H. Keratinocytes Counteract UVB-Induced Immunosuppression in Mice Via HIF-1a Signaling. J Invest Dermatol. 2021 Sep 24:S0022-202X(21)02217-X. doi: 10.1016/j.jid.2021.07.185. Online ahead of print. PMID: 34571000

Feldmann C, Bajorath J. Machine learning reveals that structural features distinguishing promis-cuous and non-promiscuous compounds depend on target combinations. Sci Rep. 2021 Apr 12;11(1):7863. doi: 10.1038/s41598-021-87042-z. PMID: 33846469 Free PMC article.

Feldmann C, Yonchev D, Bajorath J. Structured data sets of compounds with multi-target and cor-responding single-target activity from biological assays. Future Sci OA. 2021 Mar 11;7(5):FSO685. doi: 10.2144/fsoa-2020-0209. PMID: 34046190

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Feldmann C, Philipps M, Bajorath J. Explainable machine learning predictions of dual-target com-pounds reveal characteristic structural features. Sci Rep. 2021 Nov 3;11(1):21594. doi: 10.1038/s41598-021-01099-4. PMID: 34732806 Free PMC article.

Ferreira AV, Koeken VACM, Matzaraki V, Kostidis S, Alarcon-Barrera JC, de Bree LCJ, Moorlag SJCFM, Mourits VP, Novakovic B, Giera MA, Netea MG, Domínguez-Andrés J. Glutathione Metabolism Contributes to the Induction of Trained Immunity. Cells. 2021 Apr 21;10(5):971. doi: 10.3390/cells10050971. PMID: 33919212 Free PMC article.

Ferreira AV, Uijen RF, Bulut O, de Jonge MI, Domínguez-Andrés J, Netea MG. Limited role of the spleen in a mouse model of trained immunity: Impact on neutrophilia. J Leukoc Biol. 2022 Jan;111(1):9-17. doi: 10.1002/JLB.4HI0221-106RR. Epub 2021 Oct 1. PMID: 34596266

Frishberg A, van den Munckhof I, Ter Horst R, Schraa K, Joosten LA, Rutten JH, Iancu AC, Dregoesc IM, Tigu BA, Netea MG, Riksen NP, Gat-Viks I. An integrative model of cardiometabolic traits identifies two types of metabolic syndrome. Elife. 2021 Jan 28;10:e61710. doi: 10.7554/eLife.61710. PMID: 33507147

Fujii W, Kapellos TS, Baßler K, Händler K, Holsten L, Knoll R, Warnat-Herresthal S, Oestreich M, Hin-kley ER, Hasenauer J, Pizarro C, Thiele C, Aschenbrenner AC, Ulas T, Skowasch D, Schultze JL. Alveolar macrophage transcriptomic profiling in COPD shows major lipid metabolism changes. ERJ Open Res. 2021 Sep 13;7(3):00915-2020. doi: 10.1183/23120541.00915-2020. eCollection 2021 Jul. PMID: 34527724 Free PMC article.

Galati S, Yonchev D, Rodríguez-Pérez R, Vogt M, Tuccinardi T, Bajorath J. Predicting Isoform-Selective Carbonic Anhydrase Inhibitors via Machine Learning and Rationalizing Structural Features Impor-tant for Selectivity. ACS Omega. 2021 Jan 26;6(5):4080-4089. doi: 10.1021/acsomega.0c06153. eC-ollection 2021 Feb 9. PMID: 33585783

Georg P, Astaburuaga-García R, Bonaguro L, Brumhard S, Michalick L, Lippert LJ, Kostevc T, Gäbel C, Schneider M, Streitz M, Demichev V, Gemünd I, Barone M, Tober-Lau P, Helbig ET, Hillus D, Petrov L, Stein J, Dey HP, Paclik D, Iwert C, Mülleder M, Aulakh SK, Djudjaj S, Bülow RD, Mei HE, Schulz AR, Thiel A, Hippenstiel S, Saliba AE, Eils R, Lehmann I, Mall MA, Stricker S, Röhmel J, Corman VM, Beule D, Wyler E, Landthaler M, Obermayer B, von Stillfried S, Boor P, Demir M, Wesselmann H, Suttorp N, Uhrig A, Müller-Redetzky H, Nattermann J, Kuebler WM, Meisel C, Ralser M, Schultze JL, Aschen-brenner AC, Thibeault C, Kurth F, Sander LE, Blüthgen N, Sawitzki B; PA-COVID-19 Study Group. Complement activation induces excessive T cell cytotoxicity in severe COVID-19. Cell. 2021 Dec 28:S0092-8674(21)01562-2. doi: 10.1016/j.cell.2021.12.040. Online ahead of print. PMID: 35032429 Free PMC article.

Gerber JP, Russ J, Chandrasekar V, Offermann N, Lee HM, Spear S, Guzzi N, Maida S, Pattabiraman S, Zhang R, Kayvanjoo AH, Datta P, Kasturiarachchi J, Sposito T, Izotova N, Händler K, Adams PD, Marafioti T, Enver T, Wenzel J, Beyer M, Mass E, Bellodi C, Schultze JL, Capasso M, Nimmo R, Sa-lomoni P. Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haema-topoietic precursors leads to Pu.1-mediated neutrophilia and inflammation. Nat Cell Biol. 2021 Dec;23(12):1224-1239. doi: 10.1038/s41556-021-00774-y. Epub 2021 Dec 7. PMID: 34876685

Ginhoux F, Mildner A, Gautier EL, Schlitzer A, Jakubzick C, Varol C, Bain C, Guermonprez P. Editorial: Monocyte Heterogeneity and Function. Front Immunol. 2021 Jan 7;11:626725. doi: 10.3389/fim-mu.2020.626725. eCollection 2020. PMID: 33488633 Free PMC article. No abstract available.

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Hamedani NS, Biswas A, Rudan O, Tönges R, Meyring C, Tolle F, Mayer G, Oldenburg J, Müller J, Pötzsch B. Functional and Structural Characterization of Nucleic Acid Ligands That Bind to Activated Coag-ulation Factor XIII. J Clin Med. 2021 Feb 10;10(4):677. doi: 10.3390/jcm10040677. PMID: 33578732 Free PMC article.

Hansen JN, Gong A, Wachten D, Pascal R, Turpin A, Jikeli JF, Kaupp UB, Alvarez L. Multifocal imaging for precise, label-free tracking of fast biological processes in 3D. Nat Commun. 2021 Jul 28;12(1):4574. doi: 10.1038/s41467-021-24768-4. PMID: 34321468 Free PMC article.

Heng Y, Zhang X, Borggrewe M, van Weering HRJ, Brummer ML, Nijboer TW, Joosten LAB, Netea MG, Boddeke EWGM, Laman JD, Eggen BJL. Systemic administration of β-glucan induces immune training in microglia. J Neuroinflammation. 2021 Feb 22;18(1):57. doi: 10.1186/s12974-021-02103-4. PMID: 33618716

Hett T, Zbik T, Mukherjee S, Matsuoka H, Bönigk W, Klose D, Rouillon C, Brenner N, Peuker S, Klement R, Steinhoff HJ, Grubmüller H, Seifert R, Schiemann O, Kaupp UB. Spatiotemporal Resolution of Conformational Changes in Biomolecules by Combining Pulsed Electron-Electron Double Reso-nance Spectroscopy with Microsecond Freeze-Hyperquenching. J Am Chem Soc. 2021 May 12;143(18):6981-6989. doi: 10.1021/jacs.1c01081. Epub 2021 Apr 27. PMID: 33905249

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Hoersting AK, Schmucker D. Axonal branch patterning and neuronal shape diversity: roles in de-velopmental circuit assembly: Curr Opin Neurobiol. 2021 Feb;66:158-165. doi: 10.1016/j.conb.2020.10.019. Epub 2020 Nov 21. PMID: 33232861 Review.

Höhfeld J, Benzing T, Bloch W, Fürst DO, Gehlert S, Hesse M, Hoffmann B, Hoppe T, Huesgen PF, Köhn M, Kolanus W, Merkel R, Niessen CM, Pokrzywa W, Rinschen MM, Wachten D, Warscheid B. Main-taining proteostasis under mechanical stress. EMBO Rep. 2021 Aug 4;22(8):e52507. doi: 10.15252/embr.202152507. Epub 2021 Jul 26. PMID: 34309183 Free PMC article. Review.

Hückesfeld S, Schlegel P, Miroschnikow A, Schoofs A, Zinke I, Haubrich AN, Schneider-Mizell CM, Truman JW, Fetter RD, Cardona A, Pankratz MJ. Unveiling the sensory and interneuronal path-ways of the neuroendocrine connectome in Drosophila. Elife. 2021 Jun 4;10:e65745. doi: 10.7554/eLife.65745. PMID: 34085637 Free PMC article.

Hu H, Laufkötter O, Miljković F, Bajorath J. Systematic comparison of competitive and allosteric kinase inhibitors reveals common structural characteristics. Eur J Med Chem. 2021 Mar 15;214:113206. doi: 10.1016/j.ejmech.2021.113206. Epub 2021 Jan 24. PMID: 33540355

Hu H, Laufkötter O, Miljković F, Bajorath J. Data set of competitive and allosteric protein kinase in-hibitors confirmed by X-ray crystallography. Data Brief. 2021 Jan 30;35:106816. doi: 10.1016/j.dib.2021.106816. eCollection 2021 Apr. PMID: 33604432

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Hu H, Bajorath J. Systematic identification of activity cliffs with dual-atom replacements and their ra-tionalization on the basis of single-atom replacement analogs and X-ray structures. Chem Biol Drug Des. 2022 Feb;99(2):308-319. doi: 10.1111/cbdd.13985. Epub 2021 Nov 29. PMID: 34806310

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Iqbal J, Vogt M, Bajorath J. Prediction of activity cliffs on the basis of images using convolutional neu-ral networks. J Comput Aided Mol Des. 2021 Dec;35(12):1157-1164. doi: 10.1007/s10822-021-00380-y. Epub 2021 Mar 19. PMID: 33740200 Free PMC article.

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Janssen AWM, Stienstra R, Jaeger M, van Gool AJ, Joosten LAB, Netea MG, Riksen NP, Tack CJ. Under-standing the increased risk of infections in diabetes: innate and adaptive immune responses in type 1 diabetes. Metabolism. 2021 Aug;121:154795. doi: 10.1016/j.metabol.2021.154795. Epub 2021 May 8. PMID: 33971203

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Kilo L, Stürner T, Tavosanis G, Ziegler AB. Drosophila Dendritic Arborisation Neurons: Fantastic Actin Dynamics and Where to Find Them. Cells. 2021 Oct 16;10(10):2777. doi: 10.3390/cells10102777. PMID: 34685757 Free PMC article. Review.

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Hamasaki M, Han W, Hansen M, Hanson PI, Hao Z, Harada M, Harhaji-Trajkovic L, Hariharan N, Haroon N, Harris J, Hasegawa T, Hasima Nagoor N, Haspel JA, Haucke V, Hawkins WD, Hay BA, Haynes CM, Hayrabedyan SB, Hays TS, He C, He Q, He RR, He YW, He YY, Heakal Y, Heberle AM, Hejtmancik JF, Helgason GV, Henkel V, Herb M, Hergovich A, Herman-Antosiewicz A, Hernández A, Hernandez C, Hernandez-Diaz S, Hernandez-Gea V, Herpin A, Herre-ros J, Hervás JH, Hesselson D, Hetz C, Heussler VT, Higuchi Y, Hilfiker S, Hill JA, Hlavacek WS, Ho EA, Ho IHT, Ho PW, Ho SL, Ho WY, Hobbs GA, Hochstrasser M, Hoet PHM, Hofius D, Hofman P, Höhn A, Holmberg CI, Hombrebueno JR, Yi-Ren Hong CH, Hooper LV, Hoppe T, Horos R, Hoshida Y, Hsin IL, Hsu HY, Hu B, Hu D, Hu LF, Hu MC, Hu R, Hu W, Hu YC, Hu ZW, Hua F, Hua J, Hua Y, Huan C, Huang C, Huang C, Huang C, Huang C, Huang H, Huang K, Huang MLH, Huang R, Huang S, Huang T, Huang X, Huang YJ, Huber TB, Hubert V, Hubner CA, Hughes SM, Hughes WE, Humbert M, Hummer G, Hurley JH, Hussain S, Hussain S, Hussey PJ, Hutabarat M, Hwang HY, Hwang S, Ieni A, Ikeda F, Im-agawa Y, Imai Y, Imbriano C, Imoto M, Inman DM, Inoki K, Iovanna J, Iozzo RV, Ippolito G, Irazoqui JE, Iribarren P, Ishaq M, Ishikawa M, Ishimwe N, Isidoro C, Ismail N, Issazadeh-Navikas S, Itakura E, Ito D, Ivankovic D, Ivanova S, Iyer AKV, Izquierdo JM, Izumi M, Jäättelä M, Jabir MS, Jackson WT, Jacobo-Herrera N, Jacomin AC, Jacquin E, Jadiya P, Jaeschke H, Jagannath C, Jakobi AJ, Jakobsson J, Janji B, Jansen-Dürr P, Jansson PJ, Jantsch J, Januszewski S, Jassey A, Jean S, Jeltsch-David H, Jen-delova P, Jenny A, Jensen TE, Jessen N, Jewell JL, Ji J, Jia L, Jia R, Jiang L, Jiang Q, Jiang R, Jiang T, Jiang X, Jiang Y, Jimenez-Sanchez M, Jin EJ, Jin F, Jin H, Jin L, Jin L, Jin M, Jin S, Jo EK, Joffre C, Jo-hansen T, Johnson GVW, Johnston SA, Jokitalo E, Jolly MK, Joosten LAB, Jordan J, Joseph B, Ju D, Ju JS, Ju J, Juárez E, Judith D, Juhász G, Jun Y, Jung CH, Jung SC, Jung YK, Jungbluth H, Jungverdorben J, Just S, Kaarniranta K, Kaasik A, Kabuta T, Kaganovich D, Kahana A, Kain R, Kajimura S, Kalamvoki M, Kalia M, Kalinowski DS, Kaludercic N, Kalvari I, Kaminska J, Kaminskyy VO, Kanamori H, Kanasaki K, Kang C, Kang R, Kang SS, Kaniyappan S, Kanki T, Kanneganti TD, Kanthasamy AG, Kanthasamy A, Kantorow M, Kapuy O, Karamouzis MV, Karim MR, Karmakar P, Katare RG, Kato M, Kaufmann SHE, Kauppinen A, Kaushal GP, Kaushik S, Kawasaki K, Kazan K, Ke PY, Keating DJ, Keber U, Kehrl JH, Kel-ler KE, Keller CW, Kemper JK, Kenific CM, Kepp O, Kermorgant S, Kern A, Ketteler R, Keulers TG, Khalfin B, Khalil H, Khambu B, Khan SY, Khandelwal VKM, Khandia R, Kho W, Khobrekar NV, Khuan-suwan S, Khundadze M, Killackey SA, Kim D, Kim DR, Kim DH, Kim DE, Kim EY, Kim EK, Kim HR, Kim HS, Hyung-Ryong Kim, Kim JH, Kim JK, Kim JH, Kim J, Kim JH, Kim KI, Kim PK, Kim SJ, Kimball SR, Kimchi A, Kimmelman AC, Kimura T, King MA, Kinghorn KJ, Kinsey CG, Kirkin V, Kirshenbaum LA, Kiselev SL, Kishi S, Kitamoto K, Kitaoka Y, Kitazato K, Kitsis RN, Kittler JT, Kjaerulff O, Klein PS, Klop-stock T, Klucken J, Knævelsrud H, Knorr RL, Ko BCB, Ko F, Ko JL, Kobayashi H, Kobayashi S, Koch I, Koch JC, Koenig U, Kögel D, Koh YH, Koike M, Kohlwein SD, Kocaturk NM, Komatsu M, König J, Kono T, Kopp BT, Korcsmaros T, Korkmaz G, Korolchuk VI, Korsnes MS, Koskela A, Kota J, Kotake Y, Kotler ML, Kou Y, Koukourakis MI, Koustas E, Kovacs AL, Kovács T, Koya D, Kozako T, Kraft C, Krainc D, Krämer H, Krasnodembskaya AD, Kretz-Remy C, Kroemer G, Ktistakis NT, Kuchitsu K, Kuenen S, Kuerschner L, Kukar T, Kumar A, Kumar A, Kumar D, Kumar D, Kumar S, Kume S, Kumsta C, Kundu CN, Kundu M, Kunnumakkara AB, Kurgan L, Kutateladze TG, Kutlu O, Kwak S, Kwon HJ, Kwon TK, Kwon YT, Kyrmizi I, La Spada A, Labonté P, Ladoire S, Laface I, Lafont F, Lagace DC, Lahiri V, Lai Z, Laird AS, Lakkaraju A, Lamark T, Lan SH, Landajuela A, Lane DJR, Lane JD, Lang CH, Lange C, Langel Ü, Langer R, Lapaquette P, Laporte J, LaRusso NF, Lastres-Becker I, Lau WCY, Laurie GW, Lavandero

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S, Law BYK, Law HK, Layfield R, Le W, Le Stunff H, Leary AY, Lebrun JJ, Leck LYW, Leduc-Gaudet JP, Lee C, Lee CP, Lee DH, Lee EB, Lee EF, Lee GM, Lee HJ, Lee HK, Lee JM, Lee JS, Lee JA, Lee JY, Lee JH, Lee M, Lee MG, Lee MJ, Lee MS, Lee SY, Lee SJ, Lee SY, Lee SB, Lee WH, Lee YR, Lee YH, Lee Y, Lefeb-vre C, Legouis R, Lei YL, Lei Y, Leikin S, Leitinger G, Lemus L, Leng S, Lenoir O, Lenz G, Lenz HJ, Lenzi P, León Y, Leopoldino AM, Leschczyk C, Leskelä S, Letellier E, Leung CT, Leung PS, Leventhal JS, Levine B, Lewis PA, Ley K, Li B, Li DQ, Li J, Li J, Li J, Li K, Li L, Li M, Li M, Li M, Li M, Li M, Li PL, Li MQ, Li Q, Li S, Li T, Li W, Li W, Li X, Li YP, Li Y, Li Z, Li Z, Li Z, Lian J, Liang C, Liang Q, Liang W, Liang Y, Liang Y, Liao G, Liao L, Liao M, Liao YF, Librizzi M, Lie PPY, Lilly MA, Lim HJ, Lima TRR, Limana F, Lin C, Lin CW, Lin DS, Lin FC, Lin JD, Lin KM, Lin KH, Lin LT, Lin PH, Lin Q, Lin S, Lin SJ, Lin W, Lin X, Lin YX, Lin YS, Linden R, Lindner P, Ling SC, Lingor P, Linnemann AK, Liou YC, Lipinski MM, Lipovšek S, Lira VA, Li-siak N, Liton PB, Liu C, Liu CH, Liu CF, Liu CH, Liu F, Liu H, Liu HS, Liu HF, Liu H, Liu J, Liu J, Liu J, Liu L, Liu L, Liu M, Liu Q, Liu W, Liu W, Liu XH, Liu X, Liu X, Liu X, Liu X, Liu Y, Liu Y, Liu Y, Liu Y, Liu Y, Living-ston JA, Lizard G, Lizcano JM, Ljubojevic-Holzer S, LLeonart ME, Llobet-Navàs D, Llorente A, Lo CH, Lobato-Márquez D, Long Q, Long YC, Loos B, Loos JA, López MG, López-Doménech G, López-Guer-rero JA, López-Jiménez AT, López-Pérez Ó, López-Valero I, Lorenowicz MJ, Lorente M, Lorincz P, Lossi L, Lotersztajn S, Lovat PE, Lovell JF, Lovy A, Lőw P, Lu G, Lu H, Lu JH, Lu JJ, Lu M, Lu S, Luciani A, Lucocq JM, Ludovico P, Luftig MA, Luhr M, Luis-Ravelo D, Lum JJ, Luna-Dulcey L, Lund AH, Lund VK, Lünemann JD, Lüningschrör P, Luo H, Luo R, Luo S, Luo Z, Luparello C, Lüscher B, Luu L, Lyak-hovich A, Lyamzaev KG, Lystad AH, Lytvynchuk L, Ma AC, Ma C, Ma M, Ma NF, Ma QH, Ma X, Ma Y, Ma Z, MacDougald OA, Macian F, MacIntosh GC, MacKeigan JP, Macleod KF, Maday S, Madeo F, Madesh M, Madl T, Madrigal-Matute J, Maeda A, Maejima Y, Magarinos M, Mahavadi P, Maiani E, Maiese K, Maiti P, Maiuri MC, Majello B, Major MB, Makareeva E, Malik F, Mallilankaraman K, Mal-orni W, Maloyan A, Mammadova N, Man GCW, Manai F, Mancias JD, Mandelkow EM, Mandell MA, Manfredi AA, Manjili MH, Manjithaya R, Manque P, Manshian BB, Manzano R, Manzoni C, Mao K, Marchese C, Marchetti S, Marconi AM, Marcucci F, Mardente S, Mareninova OA, Margeta M, Mari M, Marinelli S, Marinelli O, Mariño G, Mariotto S, Marshall RS, Marten MR, Martens S, Martin APJ, Mar-tin KR, Martin S, Martin S, Martín-Segura A, Martín-Acebes MA, Martin-Burriel I, Martin-Rincon M, Martin-Sanz P, Martina JA, Martinet W, Martinez A, Martinez A, Martinez J, Martinez Velazquez M, Martinez-Lopez N, Martinez-Vicente M, Martins DO, Martins JO, Martins WK, Martins-Marques T, Marzetti E, Masaldan S, Masclaux-Daubresse C, Mashek DG, Massa V, Massieu L, Masson GR, 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Mizushima N, Mogensen TH, Mograbi B, Mohammadinejad R, Mohamud Y, Mohanty A, Mohapatra S, Möhlmann T, Mohmmed A, Moles A, Moley KH, Molinari M, Mollace V, Møller AB, Mollereau B, Mollinedo F, Montagna C, Monteiro MJ, Montella A, Montes LR, Montico B, Mony VK, Monzio Compagnoni G, Moore MN, Moosavi MA, Mora AL, Mora M, Morales-Alamo D, Moratalla R, Moreira PI, Morelli E, Moreno S, Moreno-Blas D, Moresi V, Morga B, Morgan AH, Morin F, Morishita H, Moritz OL, Moriyama M, Moriyasu Y, Morleo M, Morselli E, Moruno-Man-chon JF, Moscat J, Mostowy S, Motori E, Moura AF, Moustaid-Moussa N, Mrakovcic M, Muciño-Hernández G, Mukherjee A, Mukhopadhyay S, Mulcahy Levy JM, Mulero V, Muller S, Münch C, Munjal A, Munoz-Canoves P, Muñoz-Galdeano T, Münz C, Murakawa T, Muratori C, Murphy BM, Murphy JP, Murthy A, Myöhänen TT, Mysorekar IU, Mytych J, Nabavi SM, Nabissi M, Nagy P, Nah J, Nahimana A, Nakagawa I, Nakamura K, Nakatogawa H, Nandi SS, Nanjundan M, Nanni M, Napoli-tano G, Nardacci R, Narita M, Nassif M, Nathan I, Natsumeda M, Naude RJ, Naumann C, Naveiras O,

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Navid F, Nawrocki ST, Nazarko TY, Nazio F, Negoita F, Neill T, Neisch AL, Neri LM, Netea MG, Neubert P, Neufeld TP, Neumann D, Neutzner A, Newton PT, Ney PA, Nezis IP, Ng CCW, Ng TB, Nguyen HTT, Nguyen LT, Ni HM, Ní Cheallaigh C, Ni Z, Nicolao MC, Nicoli F, Nieto-Diaz M, Nilsson P, Ning S, Niran-jan R, Nishimune H, Niso-Santano M, Nixon RA, Nobili A, Nobrega C, Noda T, Nogueira-Recalde U, Nolan TM, Nombela I, Novak I, Novoa B, Nozawa T, Nukina N, Nussbaum-Krammer C, Nylandsted J, O’Donovan TR, O’Leary SM, O’Rourke EJ, O’Sullivan MP, O’Sullivan TE, Oddo S, Oehme I, Ogawa M, Ogier-Denis E, Ogmundsdottir MH, Ogretmen B, Oh GT, Oh SH, Oh YJ, Ohama T, Ohashi Y, Ohmu-raya M, Oikonomou V, Ojha R, Okamoto K, Okazawa H, Oku M, Oliván S, Oliveira JMA, Ollmann M, Olzmann JA, Omari S, Omary MB, Önal G, Ondrej M, Ong SB, Ong SG, Onnis A, Orellana JA, Orella-na-Muñoz S, Ortega-Villaizan MDM, Ortiz-Gonzalez XR, Ortona E, Osiewacz HD, Osman AK, Osta R, Otegui MS, Otsu K, Ott C, Ottobrini L, Ou JJ, 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Scott MJ, Scotto KW, Scovassi AI, Scrima A, Scrivo A, Sebastian D, Sebti S, Sedej S, Segatori L, Segev N, Seglen PO,

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Seiliez I, Seki E, Selleck SB, Sellke FW, Selsby JT, Sendtner M, Senturk S, Seranova E, Sergi C, Serra-Moreno R, Sesaki H, Settembre C, Setty SRG, Sgarbi G, Sha O, Shacka JJ, Shah JA, Shang D, Shao C, Shao F, Sharbati S, Sharkey LM, Sharma D, Sharma G, Sharma K, Sharma P, Sharma S, Shen HM, Shen H, Shen J, Shen M, Shen W, Shen Z, Sheng R, Sheng Z, Sheng ZH, Shi J, Shi X, Shi YH, Shiba-Fukushima K, Shieh JJ, Shimada Y, Shimizu S, Shimozawa M, Shintani T, Shoemaker CJ, Shojaei S, Shoji I, Shravage BV, Shridhar V, Shu CW, Shu HB, Shui K, Shukla AK, Shutt TE, Sica V, Siddiqui A, Si-erra A, Sierra-Torre V, Signorelli S, Sil P, Silva BJA, Silva JD, Silva-Pavez E, Silvente-Poirot S, Simmonds RE, Simon AK, Simon HU, Simons M, Singh A, Singh LP, Singh R, Singh SV, Singh SK, Singh SB, Singh S, Singh SP, Sinha D, Sinha RA, Sinha S, Sirko A, Sirohi K, Sivridis EL, Skendros P, Skirycz A, Slaninová I, Smaili SS, Smertenko A, Smith MD, Soenen SJ, Sohn EJ, Sok SPM, Solaini G, Soldati T, Soleiman-pour 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Knoll R, Schultze JL, Schulte-Schrepping J. Monocytes and Macrophages in COVID-19. Front Immu-nol. 2021 Jul 21;12:720109. doi: 10.3389/fimmu.2021.720109. eCollection 2021. PMID: 34367190 Free PMC article. Review.

Koeken VACM, Ganiem AR, Dian S, Ruslami R, Chaidir L, Netea MG, Kumar V, Alisjahbana B, van Crev-el R, van Laarhoven A. Cerebrospinal fluid IL-1β is elevated in tuberculous meningitis patients but not associated with mortality. Tuberculosis (Edinb). 2020 Nov 11;126:102019. doi: 10.1016/j.tube.2020.102019. Online ahead of print. PMID: 33202351

Koeken VACM, van Crevel R, Netea MG, Li Y. Resolving trained immunity with systems biology. Eur J Im-munol. 2021 Apr;51(4):773-784. doi: 10.1002/eji.202048882. Epub 2021 Mar 10. PMID: 33570164 Review.

Kong L, Moorlag SJCFM, Lefkovith A, Li B, Matzaraki V, van Emst L, Kang HA, Latorre I, Jaeger M, Joosten LAB, Netea MG, Xavier RJ. Single-cell transcriptomic profiles reveal changes associated with BCG-induced trained immunity and protective effects in circulating monocytes. Cell Rep. 2021 Nov 16;37(7):110028. doi: 10.1016/j.celrep.2021.110028. PMID: 34788625 Free PMC article.

Kopf A, Kiermaier E. Dynamic Microtubule Arrays in Leukocytes and Their Role in Cell Migration and Im-mune Synapse Formation. Front Cell Dev Biol. 2021 Feb 9;9:635511. doi: 10.3389/fcell.2021.635511. eCollection 2021. PMID: 33634136 Free PMC article. Review.

Krämer B, Knoll R, Bonaguro L, ToVinh M, Raabe J, Astaburuaga-García R, Schulte-Schrepping J, Kaiser KM, Rieke GJ, Bischoff J, Monin MB, Hoffmeister C, Schlabe S, De Domenico E, Reusch N, Händler K, Reynolds G, Blüthgen N, Hack G, Finnemann C, Nischalke HD, Strassburg CP, Stephenson E, Su Y, Gardner L, Yuan D, Chen D, Goldman J, Rosenstiel P, Schmidt SV, Latz E, Hrusovsky K, Ball AJ, Johnson JM, Koenig PA, Schmidt FI, Haniffa M, Heath JR, Kümmerer BM, Keitel V, Jensen B, Stubbe-mann P, Kurth F, Sander LE, Sawitzki B; Deutsche COVID-19 OMICS Initiative (DeCOI), Aschenbren-ner AC, Schultze JL, Nattermann J. Early IFN-α signatures and persistent dysfunction are distin-guishing features of NK cells in severe COVID-19. Immunity. 2021 Nov 9;54(11):2650-2669.e14. doi: 10.1016/j.immuni.2021.09.002. Epub 2021 Sep 4. PMID: 34592166 Free PMC article.

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Kummer MP, Ising C, Kummer C, Sarlus H, Griep A, Vieira-Saecker A, Schwartz S, Halle A, Brückner M, Händler K, Schultze JL, Beyer M, Latz E, Heneka MT. Microglial PD-1 stimulation by astrocytic PD-L1 suppresses neuroinflammation and Alzheimer’s disease pathology. EMBO J. 2021 Dec 15;40(24):e108662. doi: 10.15252/embj.2021108662. Epub 2021 Nov 26. PMID: 34825707 Free PMC article.

Kyriazopoulou E, Poulakou G, Milionis H, Metallidis S, Adamis G, Tsiakos K, Fragkou A, Rapti A, Damoulari C, Fantoni M, Kalomenidis I, Chrysos G, Angheben A, Kainis I, Alexiou Z, Castelli F, Serino FS, Tsilika M, Bakakos P, Nicastri E, Tzavara V, Kostis E, Dagna L, Koufargyris P, Dimakou K, Savvanis S, Tzatza-gou G, Chini M, Cavalli G, Bassetti M, Katrini K, Kotsis V, Tsoukalas G, Selmi C, Bliziotis I, Samarkos M, Doumas M, Ktena S, Masgala A, Papanikolaou I, Kosmidou M, Myrodia DM, Argyraki A, Cardellino CS, Koliakou K, Katsigianni EI, Rapti V, Giannitsioti E, Cingolani A, Micha S, Akinosoglou K, Liatsis-Douvitsas O, Symbardi S, Gatselis N, Mouktaroudi M, Ippolito G, Florou E, Kotsaki A, Netea MG, Eugen-Olsen J, Kyprianou M, Panagopoulos P, Dalekos GN, Giamarellos-Bourboulis EJ. Early treat-ment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma lev-els: a double-blind, randomized controlled phase 3 trial. Nat Med. 2021 Oct;27(10):1752-1760. doi: 10.1038/s41591-021-01499-z. Epub 2021 Sep 3. PMID: 34480127 Free PMC article. Clinical Trial.

Kyriazopoulou E, Poulakou G, Milionis H, Metallidis S, Adamis G, Tsiakos K, Fragkou A, Rapti A, Damoulari C, Fantoni M, Kalomenidis I, Chrysos G, Angheben A, Kainis I, Alexiou Z, Castelli F, Serino FS, Tsilika M, Bakakos P, Nicastri E, Tzavara V, Kostis E, Dagna L, Koufargyris P, Dimakou K, Savvanis S, Tzatza-gou G, Chini M, Cavalli G, Bassetti M, Katrini K, Kotsis V, Tsoukalas G, Selmi C, Bliziotis I, Samarkos M, Doumas M, Ktena S, Masgala A, Papanikolaou I, Kosmidou M, Myrodia DM, Argyraki A, Cardel-lino CS, Koliakou K, Katsigianni EI, Rapti V, Giannitsioti E, Cingolani A, Micha S, Akinosoglou K, Liatsis-Douvitsas O, Symbardi S, Gatselis N, Mouktaroudi M, Ippolito G, Florou E, Kotsaki A, Netea MG, Eugen-Olsen J, Kyprianou M, Panagopoulos P, Dalekos GN, Giamarellos-Bourboulis EJ. Au-thor Correction: Early treatment of COVID-19 with anakinra guided by soluble urokinase plasmi-nogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial. Nat Med. 2021 Oct;27(10):1850. doi: 10.1038/s41591-021-01569-2. PMID: 34625750 Free PMC article. No abstract available.

Lange C, Aaby P, Behr MA, Donald PR, Kaufmann SHE, Netea MG, Mandalakas AM. 100 years of Myco-bacterium bovis bacille Calmette-Guérin. Lancet Infect Dis. 2022 Jan;22(1):e2-e12. doi: 10.1016/S1473-3099(21)00403-5. Epub 2021 Sep 7. PMID: 34506734 Review.

Langkabel J, Horne A, Bonaguro L, Holsten L, Hesse T, Knaus A, Riedel Y, Becker M, Händler K, Elmzzahi T, Bassler K, Reusch N, Yeghiazarian LH, Pecht T, Saglam A, Ulas T, Aschenbrenner AC, Kaiser F, Kubaczka C, Schultze JL, Schorle H. Induction of Rosette-to-Lumen stage embryoids using repro-gramming paradigms in ESCs. Nat Commun. 2021 Dec 16;12(1):7322. doi: 10.1038/s41467-021-27586-w. PMID: 34916498 Free PMC article.

Laufkötter O, Hu H, Miljković F, Bajorath J. Structure- and Similarity-Based Survey of Allosteric Kinase Inhibitors, Activators, and Closely Related Compounds. J Med Chem. 2022 Jan 27;65(2):922-934. doi: 10.1021/acs.jmedchem.0c02076. Epub 2021 Jan 21. PMID: 33476146

Lauterbach MA, Saavedra V, Mangan MSJ, Penno A, Thiele C, Latz E, Kuerschner L. 1-Deoxysphin-golipids cause autophagosome and lysosome accumulation and trigger NLRP3 inflammasome activation. Autophagy. 2021 Aug;17(8):1947-1961. doi: 10.1080/15548627.2020.1804677. Epub 2020 Aug 24. PMID: 32835606 Free PMC article.

Lensen R, Netea MG, Rosendaal FR. Hepatitis C Virus Reactivation Following COVID-19 Vaccination - A Case Report. Int Med Case Rep J. 2021 Aug 29;14:573-576. doi: 10.2147/IMCRJ.S328482. eCollec-tion 2021. PMID: 34512037 Free PMC article.

López-López E, Bajorath J, Medina-Franco JL. Informatics for Chemistry, Biology, and Biomedical Sci-ences. J Chem Inf Model. 2021 Jan 25;61(1):26-35. doi: 10.1021/acs.jcim.0c01301. Epub 2020 Dec 31. PMID: 33382611

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Maggiora G, Vogt M. Set-Theoretic Formalism for Treating Ligand-Target Datasets. Molecules. 2021 Dec 7;26(24):7419. doi: 10.3390/molecules26247419. PMID: 34946500 Free PMC article.

Mahn M, Saraf-Sinik I, Patil P, Pulin M, Bitton E, Karalis N, Bruentgens F, Palgi S, Gat A, Dine J, Wietek J, Davidi I, Levy R, Litvin A, Zhou F, Sauter K, Soba P, Schmitz D, Lüthi A, Rost BR, Wiegert JS, Yizhar O. Efficient optogenetic silencing of neurotransmitter release with a mosquito rhodopsin. Neuron. 2021 May 19;109(10):1621-1635.e8. doi: 10.1016/j.neuron.2021.03.013. Epub 2021 May 11. PMID: 33979634

Makdissi N, Mass E. Of myeloid cells and fibroblasts-A love story. Immunity. 2021 Jul 13;54(7):1371-1373. doi: 10.1016/j.immuni.2021.06.016. PMID: 34260884

Mass E, Lachmann N. From macrophage biology to macrophage-based cellular immunotherapies. Gene Ther. 2021 Sep;28(9):473-476. doi: 10.1038/s41434-021-00221-5. Epub 2021 Feb 4. PMID: 33542457

Mass E, Gentek R. Fetal-Derived Immune Cells at the Roots of Lifelong Pathophysiology. Front Cell Dev Biol. 2021 Feb 23;9:648313. doi: 10.3389/fcell.2021.648313. eCollection 2021. PMID: 33708774 Free PMC article. Review.

Matzaraki V, Le KTT, Jaeger M, Aguirre-Gamboa R, Johnson MD, Sanna S, Rosati D, Franke L, Zhernakova A, Fu J, Withoff S, Jonkers I, Li Y, Joosten LAB, Netea MG, Wijmenga C, Kumar V. Inflammatory Protein Profiles in Plasma of Candidaemia Patients and the Contribution of Host Genetics to Their Variability. Front Immunol. 2021 Aug 26;12:662171. doi: 10.3389/fimmu.2021.662171. eCollection 2021. PMID: 34512620 Free PMC article.

Medina-Franco JL, Martinez-Mayorga K, Fernández-de Gortari E, Kirchmair J, Bajorath J. Rationality over fashion and hype in drug design. F1000Res. 2021 May 18;10:Chem Inf Sci-397. doi: 10.12688/f1000research.52676.1. eCollection 2021. PMID: 34164109

Melaiu O, Macauda A, Sainz J, Calvetti D, Facioni MS, Maccari G, Ter Horst R, Netea MG, Li Y, Grząśko N, Moreno V, Jurczyszyn A, Jerez A, Watek M, Varkonyi J, Garcia-Sanz R, Kruszewski M, Dudziński M, Kadar K, Jacobsen SEH, Mazur G, Andersen V, Rybicka M, Zawirska D, Raźny M, Zaucha JM, Ostro-vsky O, Iskierka-Jazdzewska E, Reis RM, Stępień A, Beider K, Nagler A, Druzd-Sitek A, Marques H, Martìnez-Lopez J, Lesueur F, Avet-Loiseau H, Vangsted AJ, Krawczyk-Kulis M, Butrym A, Jamroziak K, Dumontet C, Vogel U, Rymko M, Pelosini M, Subocz E, Szombath G, Sarasquete ME, Silvestri R, Morani F, Landi S, Campa D, Canzian F, Gemignani F. Common gene variants within 3’-untranslated regions as modulators of multiple myeloma risk and survival. Int J Cancer. 2021 Apr 15;148(8):1887-1894. doi: 10.1002/ijc.33377. Epub 2020 Nov 20. PMID: 33152124

Mertins J, Finke J, Sies R, Rink KM, Hasenauer J, Lang T. The mesoscale organization of syntaxin 1A and SNAP25 is determined by SNARE-SNARE interactions. Elife. 2021 Nov 15;10:e69236. doi: 10.7554/eLife.69236. PMID: 34779769 Free PMC article.

Miljković F, Rodríguez-Pérez R, Bajorath J. Impact of Artificial Intelligence on Compound Discovery, De-sign, and Synthesis. ACS Omega. 2021 Nov 29;6(49):33293-33299. doi: 10.1021/acsomega.1c05512. eCollection 2021 Dec 14. PMID: 34926881 Free PMC article. Review.

Mizuno Y, Imura E, Kurogi Y, Shimada-Niwa Y, Kondo S, Tanimoto H, Hückesfeld S, Pankratz MJ, Niwa R. A population of neurons that produce hugin and express the diuretic hormone 44 receptor gene projects to the corpora allata in Drosophila melanogaster. Dev Growth Differ. 2021 May 22. doi: 10.1111/dgd.12733. Online ahead of print. PMID: 34021588

Mohamed L, Madsen AMR, Schaltz-Buchholzer F, Ostenfeld A, Netea MG, Benn CS, Kofoed PE. Reactiva-tion of BCG vaccination scars after vaccination with mRNA-Covid-vaccines: two case reports. BMC Infect Dis. 2021 Dec 20;21(1):1264. doi: 10.1186/s12879-021-06949-0. PMID: 34930152 Free PMC article. Clinical Trial.

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Moorlag SJCFM, Matzaraki V, van Puffelen JH, van der Heijden C, Keating S, Groh L, Röring RJ, Bakker OB, Koeken VACM, de Bree LCJ, Smeekens SP, Oosting M, Gamboa RA, Riksen NP, Xavier RJ, Wijmenga C, Kumar V, van Crevel R, Novakovic B, Joosten LAB, Li Y, Netea MG. An integrative genomics ap-proach identifies KDM4 as a modulator of trained immunity. Eur J Immunol. 2021 Nov 25. doi: 10.1002/eji.202149577. Online ahead of print. PMID: 34821391

Moronta-Barrios F, Vargas-Domínguez S, Nuesch-Germano M, Torres V, Selvaggi K, Di Prinzio C, O’Brien E, Hernandez V, Monteiro M. Latin American Network for Scientific Culture (RedLCC): A Region-al Science Communication Initiative. Front Res Metr Anal. 2021 Mar 23;6:654022. doi: 10.3389/frma.2021.654022. eCollection 2021. PMID: 33870070 Free PMC article.

Mourits VP, van Puffelen JH, Novakovic B, Bruno M, Ferreira AV, Arts RJ, Groh L, Crișan TO, Zwaag J, Jentho E, Kox M, Pickkers P, van de Veerdonk FL, Weis S, Oosterwijk E, Vermeulen SH, Netea MG, Joos-ten LA. Lysine methyltransferase G9a is an important modulator of trained immunity. Clin Transl Immunology. 2021 Feb 18;10(2):e1253. doi: 10.1002/cti2.1253. eCollection 2021. PMID: 33708384 Free PMC article.

Mourits VP, Helder LS, Matzaraki V, Koeken VACM, Groh L, de Bree LCJ, Moorlag SJCFM, van der Hei-jden CDCC, Keating ST, van Puffelen JH, Jaeger M, Joosten LAB, Netea MG. The role of sirtuin 1 on the induction of trained immunity. Cell Immunol. 2021 Aug;366:104393. doi: 10.1016/j.cel-limm.2021.104393. Epub 2021 Jun 12. PMID: 34147841

Molteni R, Biavasco R, Stefanoni D, Nemkov T, Domínguez-Andrés J, Arts RJ, Merelli I, Mazza D, Zambrano S, Panigada M, Cantoni E, Tengesdal IW, Maksud P, Piras F, Cesana D, Cassina L, Distefano G, Loffre-da A, Gnani D, De Luca G, Tomelleri A, Campochiaro C, Joosten LAB, Dinarello CA, Kajaste-Rudnitski A, Haroche J, Cardaci S, Cenci S, Dagna L, Doglioni C, Ferrarini M, Ferrero E, Boletta A, D’Alessandro A, Montini E, Netea MG, Cavalli G. Oncogene-induced maladaptive activation of trained immunity in the pathogenesis and treatment of Erdheim-Chester disease. Blood. 2021 Oct 28;138(17):1554-1569. doi: 10.1182/blood.2020009594. PMID: 34077954

Müller P, Sahlbach M, Gasper S, Mayer G, Müller J, Pötzsch B, Heckel A. Controlling Coagulation in Blood with Red Light. Angew Chem Int Ed Engl. 2021 Oct 4;60(41):22441-22446. doi: 10.1002/anie.202108468. Epub 2021 Aug 31. PMID: 34293228 Free PMC article.

Muus C, Luecken MD, Eraslan G, Sikkema L, Waghray A, Heimberg G, Kobayashi Y, Vaishnav ED, Subra-manian A, Smillie C, Jagadeesh KA, Duong ET, Fiskin E, Triglia ET, Ansari M, Cai P, Lin B, Buchanan J, Chen S, Shu J, Haber AL, Chung H, Montoro DT, Adams T, Aliee H, Allon SJ, Andrusivova Z, Angelidis I, Ashenberg O, Bassler K, Bécavin C, Benhar I, Bergenstråhle J, Bergenstråhle L, Bolt L, Braun E, Bui LT, Callori S, Chaffin M, Chichelnitskiy E, Chiou J, Conlon TM, Cuoco MS, Cuomo ASE, Deprez M, Duclos G, Fine D, Fischer DS, Ghazanfar S, Gillich A, Giotti B, Gould J, Guo M, Gutierrez AJ, Haber-mann AC, Harvey T, He P, Hou X, Hu L, Hu Y, Jaiswal A, Ji L, Jiang P, Kapellos TS, Kuo CS, Larsson L, Leney-Greene MA, Lim K, Litviňuková M, Ludwig LS, Lukassen S, Luo W, Maatz H, Madissoon E, Mamanova L, Manakongtreecheep K, Leroy S, Mayr CH, Mbano IM, McAdams AM, Nabhan AN, Nyquist SK, Penland L, Poirion OB, Poli S, Qi C, Queen R, Reichart D, Rosas I, Schupp JC, Shea CV, Shi X, Sinha R, Sit RV, Slowikowski K, Slyper M, Smith NP, Sountoulidis A, Strunz M, Sullivan TB, Sun D, Talavera-López C, Tan P, Tantivit J, Travaglini KJ, Tucker NR, Vernon KA, Wadsworth MH, Waldman J, Wang X, Xu K, Yan W, Zhao W, Ziegler CGK; NHLBI LungMap Consortium; Human Cell Atlas Lung Biological Network. Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demo-graphics. Nat Med. 2021 Mar;27(3):546-559. doi: 10.1038/s41591-020-01227-z. Epub 2021 Mar 2. PMID: 33654293

Naveja JJ, Vogt M. Automatic Identification of Analogue Series from Large Compound Data Sets: Meth-ods and Applications. Molecules. 2021 Aug 31;26(17):5291. doi: 10.3390/molecules26175291. PMID: 34500724 Free PMC article. Review.

Netea MG, van der Meer JW, van Crevel R. BCG vaccination in health care providers and the protec-tion against COVID-19. J Clin Invest. 2021 Jan 19;131(2):e145545. doi: 10.1172/JCI145545. PMID: 33306484

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Netea MG, Li Y. Immune memory in individuals with COVID-19. Nat Cell Biol. 2021 Jun;23(6):582-584. doi: 10.1038/s41556-021-00689-8. PMID: 34108656 No abstract available.

Netea MG, van Crevel R. Assessing the effect of BCG revaccination on long-term mortality. Lancet In-fect Dis. 2021 Nov;21(11):1481-1483. doi: 10.1016/S1473-3099(21)00055-4. Epub 2021 Jul 5. PMID: 34237263 No abstract available.

Netea MG. The epigenetic ghost of infections past. Nat Rev Immunol. 2021 Oct;21(10):622-623. doi: 10.1038/s41577-021-00605-z. PMID: 34580462 No abstract available.

Netea MG, Domínguez-Andrés J, van de Veerdonk FL, van Crevel R, Pulendran B, van der Meer JWM. Natural resistance against infections: focus on COVID-19. Trends Immunol. 2021 Dec 7:S1471-4906(21)00259-3. doi: 10.1016/j.it.2021.12.001. Online ahead of print. PMID: 34924297 Free PMC article. Review.

Niehues H, van der Krieken DA, Ederveen THA, Jansen PAM, van Niftrik L, Mesman R, Netea MG, Smits JPH, Schalkwijk J, van den Bogaard EH, Zeeuwen PLJM. Antimicrobial late cornified envelope (LCE) proteins: the psoriasis risk factor LCE3B/C-del affects microbiota composition. J Invest Dermatol. 2021 Dec 20:S0022-202X(21)02618-X. doi: 10.1016/j.jid.2021.11.036. Online ahead of print. PMID: 34942199

Novak N, Weighardt H, Valdelvira R, Izquierdo E, Förster I, Cabanillas B. Herpes simplex virus 1 pro-teins can induce skin inflammation in an atopic dermatitis-like mouse model. Exp Dermatol. 2021 Nov;30(11):1699-1704. doi: 10.1111/exd.14327. Epub 2021 Mar 22. PMID: 33751678

Noz MP, Ter Telgte A, Wiegertjes K, Tuladhar AM, Kaffa C, Kersten S, Bekkering S, van der Heijden CDCC, Hoischen A, Joosten LAB, Netea MG, Duering M, de Leeuw FE, Riksen NP. Pro-inflammatory Mono-cyte Phenotype During Acute Progression of Cerebral Small Vessel Disease. Front Cardiovasc Med. 2021 May 13;8:639361. doi: 10.3389/fcvm.2021.639361. eCollection 2021. PMID: 34055930

Noz MP, Plachokova AS, Smeets EMM, Aarntzen EHJG, Bekkering S, Vart P, Joosten LAB, Netea MG, Rik-sen NP. An Explorative Study on Monocyte Reprogramming in the Context of Periodontitis In Vitro and In Vivo. Front Immunol. 2021 Aug 13;12:695227. doi: 10.3389/fimmu.2021.695227. eCollec-tion 2021. PMID: 34484192 Free PMC article.

Oestreich M, Chen D, Schultze JL, Fritz M, Becker M. Privacy considerations for sharing genomics data. EXCLI J. 2021 Jul 16;20:1243-1260. doi: 10.17179/excli2021-4002. eCollection 2021. PMID: 34345236 Free PMC article. Review.

Ortega AD, Takhaveev V, Vedelaar SR, Long Y, Mestre-Farràs N, Incarnato D, Ersoy F, Olsen LF, Mayer G, Heinemann M. A synthetic RNA-based biosensor for fructose-1,6-bisphosphate that reports glyco-lytic flux. Cell Chem Biol. 2021 Nov 18;28(11):1554-1568.e8. doi: 10.1016/j.chembiol.2021.04.006. Epub 2021 Apr 28. PMID: 33915105

Osuchowski MF, Winkler MS, Skirecki T, Cajander S, Shankar-Hari M, Lachmann G, Monneret G, Venet F, Bauer M, Brunkhorst FM, Weis S, Garcia-Salido A, Kox M, Cavaillon JM, Uhle F, Weigand MA, Flohé SB, Wiersinga WJ, Almansa R, de la Fuente A, Martin-Loeches I, Meisel C, Spinetti T, Schefold JC, Cil-loniz C, Torres A, Giamarellos-Bourboulis EJ, Ferrer R, Girardis M, Cossarizza A, Netea MG, van der Poll T, Bermejo-Martín JF, Rubio I. The COVID-19 puzzle: deciphering pathophysiology and phe-notypes of a new disease entity. Lancet Respir Med. 2021 Jun;9(6):622-642. doi: 10.1016/S2213-2600(21)00218-6. Epub 2021 May 6. PMID: 33965003 Free PMC article. Review.

Palma C, La Rocca C, Gigantino V, Aquino G, Piccaro G, Di Silvestre D, Brambilla F, Rossi R, Bonacina F, Lepore MT, Audano M, Mitro N, Botti G, Bruzzaniti S, Fusco C, Procaccini C, De Rosa V, Galgani M, Alviggi C, Puca A, Grassi F, Rezzonico-Jost T, Norata GD, Mauri P, Netea MG, de Candia P, Matarese G. Caloric Restriction Promotes Immunometabolic Reprogramming Leading to Protection from Tuberculosis. Cell Metab. 2021 Feb 2;33(2):300-318.e12. doi: 10.1016/j.cmet.2020.12.016. Epub 2021 Jan 8. PMID: 33421383

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Peres NG, Wang N, Whitney P, Engel S, Shreenivas MM, Comerford I, Hocking DM, Erazo AB, Förster I, Kupz A, Gebhardt T, McColl SR, McSorley SJ, Bedoui S, Strugnell RA. CD4+ T cell immunity to Sal-monella is transient in the circulation. PLoS Pathog. 2021 Oct 25;17(10):e1010004. doi: 10.1371/journal.ppat.1010004. eCollection 2021 Oct. PMID: 34695149 Free PMC article.

Piazzesi A, Afsar SY, van Echten-Deckert G. Sphingolipid metabolism in the development and pro-gression of cancer: one cancer’s help is another’s hindrance. Mol Oncol. 2021 Dec;15(12):3256-3279. doi: 10.1002/1878-0261.13063. Epub 2021 Jul 29. PMID: 34289244 Free PMC article. Review.

Pietruś W, Kurczab R, Stumpfe D, Bojarski AJ, Bajorath J. Data-Driven Analysis of Fluorination of Li-gands of Aminergic G Protein Coupled Receptors. Biomolecules. 2021 Nov 8;11(11):1647. doi: 10.3390/biom11111647. PMID: 34827645 Free PMC article.

Pirr S, Dauter L, Vogl T, Ulas T, Bohnhorst B, Roth J, Viemann D. S100A8/A9 is the first predictive marker for neonatal sepsis. Clin Transl Med. 2021 Apr;11(4):e338. doi: 10.1002/ctm2.338. PMID: 33931974 Free PMC article. No abstract available.

Post A, Kaboré B, Berendsen M, Diallo S, Traore O, Arts RJW, Netea MG, Joosten LAB, Tinto H, Jacobs J, de Mast Q, van der Ven A. Altered Ex-Vivo Cytokine Responses in Children With Asymptomatic Plasmodium falciparum Infection in Burkina Faso: An Additional Argument to Treat Asymptomat-ic Malaria? Front Immunol. 2021 Jun 9;12:614817. doi: 10.3389/fimmu.2021.614817. eCollection 2021. PMID: 34177883 Free PMC article.

Prentice S, Nassanga B, Webb EL, Akello F, Kiwudhu F, Akurut H, Elliott AM, Arts RJW, Netea MG, Dockrell HM, Cose S; Delayed BCG Study Team. BCG-induced non-specific effects on heterologous infec-tious disease in Ugandan neonates: an investigator-blind randomised controlled trial. Lancet In-fect Dis. 2021 Jul;21(7):993-1003. doi: 10.1016/S1473-3099(20)30653-8. Epub 2021 Feb 17. PMID: 33609457 Free PMC article. Clinical Trial.

Prisco L, Deimel SH, Yeliseyeva H, Fiala A, Tavosanis G. The anterior paired lateral neuron normalizes odour-evoked activity in the Drosophila mushroom body calyx. Elife. 2021 Dec 29;10:e74172. doi: 10.7554/eLife.74172. PMID: 34964714 Free PMC article.

Rafeld HL, Kolanus W, van Driel IR, Hartland EL. Interferon-induced GTPases orchestrate host cell-au-tonomous defence against bacterial pathogens. Biochem Soc Trans. 2021 Jun 30;49(3):1287-1297. doi: 10.1042/BST20200900. PMID: 34003245 Free PMC article.

Rajewsky N, Almouzni G, Gorski SA, Aerts S, Amit I, Bertero MG, Bock C, Bredenoord AL, Cavalli G, Chiocca S, Clevers H, De Strooper B, Eggert A, Ellenberg J, Fernández XM, Figlerowicz M, Gasser SM, Hubner N, Kjems J, Knoblich JA, Krabbe G, Lichter P, Linnarsson S, Marine JC, Marioni JC, Marti-Renom MA, Netea MG, Nickel D, Nollmann M, Novak HR, Parkinson H, Piccolo S, Pinheiro I, Pombo A, Popp C, Reik W, Roman-Roman S, Rosenstiel P, Schultze JL, Stegle O, Tanay A, Testa G, Thanos D, Theis FJ, Torres-Padilla ME, Valencia A, Vallot C, van Oudenaarden A, Vidal M, Voet T; LifeTime Community Working Groups. Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine. Nature. 2021 Apr;592(7852):E8. doi: 10.1038/s41586-021-03287-8. PMID: 33731935 Free PMC article. No abstract available.

Reusch N, De Domenico E, Bonaguro L, Schulte-Schrepping J, Baßler K, Schultze JL, Aschenbren-ner AC. Neutrophils in COVID-19. Front Immunol. 2021 Mar 25;12:652470. doi: 10.3389/fim-mu.2021.652470. eCollection 2021. PMID: 33841435 Free PMC article. Review.

Reusch N, Ravichandran KA, Olabiyi BF, Komorowska-Müller JA, Hansen JN, Ulas T, Beyer M, Zimmer A, Schmöle AC. Cannabinoid receptor 2 is necessary to induce toll-like receptor-mediated microglial activation. Glia. 2022 Jan;70(1):71-88. doi: 10.1002/glia.24089. Epub 2021 Sep 9. PMID: 34499767

Rodríguez-Pérez R, Bajorath J. Feature importance correlation from machine learning indicates func-tional relationships between proteins and similar compound binding characteristics. Sci Rep. 2021 Jul 9;11(1):14245. doi: 10.1038/s41598-021-93771-y. PMID: 34244588 Free PMC article.

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Rodríguez-Pérez R, Bajorath J. Evaluation of multi-target deep neural network models for compound potency prediction under increasingly challenging test conditions. J Comput Aided Mol Des. 2021 Mar;35(3):285-295. doi: 10.1007/s10822-021-00376-8. Epub 2021 Feb 17. PMID: 33598870 Free PMC article.

Rodríguez-Pérez R, Bajorath J. Explainable Machine Learning for Property Predictions in Compound Optimization. J Med Chem. 2021 Dec 23;64(24):17744-17752. doi: 10.1021/acs.jmedchem.1c01789. Epub 2021 Dec 13. PMID: 34902252

Rodriguez-Rosales YA, Langereis JD, Gorris MAJ, van den Reek JMPA, Fasse E, Netea MG, de Vries IJM, Gomez-Muñoz L, van Cranenbroek B, Körber A, Sondermann W, Joosten I, de Jong EMGJ, Koenen HJPM.Immunomodulatory aged neutrophils are augmented in blood and skin of psoriasis pa-tients. J Allergy Clin Immunol. 2021 Oct;148(4):1030-1040. doi: 10.1016/j.jaci.2021.02.041. Epub 2021 Mar 19. PMID: 33745888

Rösler B, Heinhuis B, Wang X, Silvestre R, Joosten LAB, Netea MG, Arts P, Mantere T, Lefeber DJ, Hoischen A, van de Veerdonk FL. Mimicking Behçet’s disease: GM-CSF gain of function mutation in a family suffering from a Behçet’s disease-like disorder marked by extreme pathergy. Clin Exp Immunol. 2021 May;204(2):189-198. doi: 10.1111/cei.13568. Epub 2021 Jan 28. PMID: 33349924

Sainz J, García-Verdejo FJ, Martínez-Bueno M, Kumar A, Sánchez-Maldonado JM, Díez-Villanueva A, Vodičková L, Vymetálková V, Martin Sánchez V, Da Silva Filho MI, Sampaio-Marques B, Brezina S, But-terbach K, Ter Horst R, Hoffmeister M, Ludovico P, Jurado M, Li Y, Sánchez-Rovira P, Netea MG, Gsur A, Vodička P, Moreno V, Hemminki K, Brenner H, Chang-Claude J, Försti A. Polymorphisms within Autophagy-Related Genes Influence the Risk of Developing Colorectal Cancer: A Meta-Analysis of Four Large Cohorts. S Cancers (Basel). 2021 Mar 12;13(6):1258. doi: 10.3390/cancers13061258. PMID: 33809172

Sánchez-Maldonado JM, Cáliz R, López-Nevot MÁ, Cabrera-Serrano AJ, Moñiz-Díez A, Canhão H, Ter Horst R, Quartuccio L, Sorensen SB, Glintborg B, Hetland ML, Filipescu I, Pérez-Pampin E, Conesa-Zamora P, Swierkot J, den Broeder AA, De Vita S, Petersen ERB, Li Y, Ferrer MA, Escudero A, Netea MG, Coenen MJH, Andersen V, Fonseca JE, Jurado M, Bogunia-Kubik K, Collantes E, Sainz J. Validation of GWAS-Identified Variants for Anti-TNF Drug Response in Rheumatoid Arthritis: A Meta-Analysis of Two Large Cohorts. Front Immunol. 2021 Oct 27;12:672255. doi: 10.3389/fimmu.2021.672255. eCollection 2021. PMID: 34777329 Free PMC article.

Sandhoff K. Secondary ganglioside GM2 accumulation in mucopolysaccharidoses. Mol Genet Metab Rep. 2021 Aug 12;28:100789. doi: 10.1016/j.ymgmr.2021.100789. eCollection 2021 Sep. PMID: 34485082 Free PMC article. No abstract available.

Schmitz A, Weber A, Bayin M, Breuers S, Fieberg V, Famulok M, Mayer G. A SARS-CoV-2 Spike Bind-ing DNA Aptamer that Inhibits Pseudovirus Infection by an RBD-Independent Mechanism*. An-gew Chem Int Ed Engl. 2021 Apr 26;60(18):10279-10285. doi: 10.1002/anie.202100316. Epub 2021 Mar 23. PMID: 33683787

Schmitz A, Weber A, Bayin M, Breuers S, Fieberg V, Famulok M, Mayer G. A SARS-CoV-2 Spike Bind-ing DNA Aptamer that Inhibits Pseudovirus Infection by an RBD-Independent Mechanism. Angew Chem Weinheim Bergstr Ger. 2021 Apr 26;133(18):10367-10373. doi: 10.1002/ange.202100316. Epub 2021 Mar 25. PMID: 34230708

Schultze JL, Aschenbrenner AC. COVID-19 and the human innate immune system. Cell. 2021 Apr 1;184(7):1671-1692. doi: 10.1016/j.cell.2021.02.029. Epub 2021 Feb 16. PMID: 33743212 Free PMC article. Review.

Schultze JL. Deutsche COVID-19 Omics Initiative (DeCOI). Biospektrum (Heidelb). 2021;27(3):227. doi: 10.1007/s12268-021-1586-4. Epub 2021 May 11. PMID: 33994671

Singh AK, Netea MG, Bishai WR. BCG turns 100: its nontraditional uses against viruses, cancer, and im-munologic diseases. J Clin Invest. 2021 Jun 1;131(11):e148291. doi: 10.1172/JCI148291. PMID: 34060492 Review.

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Sohrabi Y, Reinecke H, Joosten LAB, Netea MG. Deadly COVID-19 among the elderly: Innate im-mune memory helping those most in need. Med (N Y). 2021 Apr 9;2(4):378-383. doi: 10.1016/j.medj.2021.02.004. Epub 2021 Feb 24. PMID: 33649749

Stražar M, Mourits VP, Koeken VACM, de Bree LCJ, Moorlag SJCFM, Joosten LAB, van Crevel R, Vlamakis H, Netea MG, Xavier RJ. The influence of the gut microbiome on BCG-induced trained immunity. Genome Biol. 2021 Sep 22;22(1):275. doi: 10.1186/s13059-021-02482-0. PMID: 34551799 Free PMC article.

Stumpfe D, Hoch A, Bajorath J. Introducing the metacore concept for multi-target ligand design. RSC Med Chem. 2021 Apr 15;12(4):628-635. doi: 10.1039/d1md00056j. eCollection 2021 Apr 28. PMID: 34046634

Suen TK, Al B, Placek K. Cell-to-cell proteome variability: life in a cycle. Signal Transduct Target Ther. 2021 Jun 10;6(1):229. doi: 10.1038/s41392-021-00655-8. PMID: 34112757 Free PMC article. No ab-stract available.

Takeuchi K, Kunimoto R, Bajorath J. R-group replacement database for medicinal chemistry. Future Sci OA. 2021 Jun 30;7(8):FSO742. doi: 10.2144/fsoa-2021-0062. eCollection 2021 Sep. PMID: 34295541 Free PMC article.

Takeuchi K, Kunimoto R, Bajorath J. Systematic mapping of R-group space enables the generation of an R-group replacement system for medicinal chemistry. Eur J Med Chem. 2021 Dec 5;225:113771. doi: 10.1016/j.ejmech.2021.113771. Epub 2021 Aug 12. PMID: 34403977

Takeuchi K, Kunimoto R, Bajorath J. Searchable database of frequent R-groups in medicinal chemistry and their preferred replacements. Data Brief. 2021 Oct 8;39:107456. doi: 10.1016/j.dib.2021.107456. eCollection 2021 Dec. PMID: 34692956 Free PMC article.

Tavosanis G. Dendrite enlightenment. Curr Opin Neurobiol. 2021 Aug;69:222-230. doi: 10.1016/j.conb.2021.05.001. Epub 2021 Jun 13. PMID: 34134010 Review.

Temba GS, Kullaya V, Pecht T, Mmbaga BT, Aschenbrenner AC, Ulas T, Kibiki G, Lyamuya F, Boahen CK, Kumar V, Joosten LAB, Schultze JL, van der Ven AJ, Netea MG, de Mast Q. Urban living in healthy Tanzanians is associated with an inflammatory status driven by dietary and metabolic changes. Nat Immunol. 2021 Mar;22(3):287-300. doi: 10.1038/s41590-021-00867-8. Epub 2021 Feb 11. PMID: 33574617

Ter Horst R, Jaeger M, van de Wijer L, van der Heijden WA, Janssen AMW, Smeekens SP, Brouwer MAE, van Cranenbroek B, Aguirre-Gamboa R, Netea-Maier RT, van Herwaarden AE, Lemmers H, Dijkstra H, Joosten I, Koenen H, Netea MG, Joosten LAB. Seasonal and Nonseasonal Longitudinal Variation of Immune Function. J Immunol. 2021 Jul 14:ji2000133. doi: 10.4049/jimmunol.2000133. Online ahead of print. PMID: 34261668

Ter Steeg L, Domínguez-Andrés J, Netea MG, Joosten LAB, van Crevel R. Trained Immunity as a Pre-ventive Measure for Surgical Site Infections. Clin Microbiol Rev. 2021 Dec 15;34(4):e0004921. doi: 10.1128/CMR.00049-21. Epub 2021 Sep 29. PMID: 34585978

Tercan H, Riksen NP, Joosten LAB, Netea MG, Bekkering S. Trained Immunity: Long-Term Adaptation in Innate Immune Responses. Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):55-61. doi: 10.1161/AT-VBAHA.120.314212. Epub 2020 Oct 22. PMID: 33086868

Teufel LU, Arts RJW, Netea MG, Dinarello CA, Joosten LAB. IL-1 family cytokines as drivers and inhibitors of trained immunity. Cytokine. 2022 Feb;150:155773. doi: 10.1016/j.cyto.2021.155773. Epub 2021 Nov 26. PMID: 34844039

Torres Fernández LA, Mitschka S, Ulas T, Weise S, Dahm K, Becker M, Händler K, Beyer M, Wind-hausen J, Schultze JL, Kolanus W. The stem cell-specific protein TRIM71 inhibits maturation and activity of the pro-differentiation miRNA let-7 via two independent molecular mechanisms. RNA. 2021 May 11:rna.078696.121. doi: 10.1261/rna.078696.121. Online ahead of print. PMID: 33975917

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Torres-Fernández LA, Emich J, Port Y, Mitschka S, Wöste M, Schneider S, Fietz D, Oud MS, Di Persio S, Neuhaus N, Kliesch S, Hölzel M, Schorle H, Friedrich C, Tüttelmann F, Kolanus W. TRIM71 Defi-ciency Causes Germ Cell Loss During Mouse Embryogenesis and Is Associated With Human Male Infertility. Front Cell Dev Biol. 2021 May 13;9:658966. doi: 10.3389/fcell.2021.658966. eCollection 2021. PMID: 34055789

Tsai YA, Li T, Torres-Fernández LA, Weise SC, Kolanus W, Takeoka S. Ultra-Thin Porous PDLLA Films Promote Generation, Maintenance, and Viability of Stem Cell Spheroids. Front Bioeng Biotechnol. 2021 Jun 14;9:674384. doi: 10.3389/fbioe.2021.674384. eCollection 2021. PMID: 34195179 Free PMC article.

Ulas T, Aschenbrenner AC. Neue Krankheiten mit Bluttranskriptomik entschlüsseln. Biospektrum (Hei-delb). 2021;27(4):372-375. doi: 10.1007/s12268-021-1590-8. Epub 2021 Jun 26. PMID: 34219982

Umer N, Arévalo L, Phadke S, Lohanadan K, Kirfel G, Sons D, Sofia D, Witke W, Schorle H. Loss of Profi-lin3 Impairs Spermiogenesis by Affecting Acrosome Biogenesis, Autophagy, Manchette Develop-ment and Mitochondrial Organization. Front Cell Dev Biol. 2021 Nov 4;9:749559. doi: 10.3389/fcell.2021.749559. eCollection 2021. PMID: 34869336 Free PMC article.

Vadaq N, Schirmer M, Tunjungputri RN, Vlamakis H, Chiriac C, Ardiansyah E, Gasem MH, Joosten LAB, de Groot PG, Xavier RJ, Netea MG, van der Ven AJ, de Mast Q. Untargeted Plasma Metabolomics and Gut Microbiome Profiling Provide Novel Insights into the Regulation of Platelet Reactivity in Healthy Individuals. Thromb Haemost. 2021 Jun 30. doi: 10.1055/a-1541-3706. Online ahead of print. PMID: 34192775

van de Veerdonk FL, Netea MG. Rare variants increase the risk of severe COVID-19. Elife. 2021 Mar 23;10:e67860. doi: 10.7554/eLife.67860. PMID: 33752797 Free PMC article.

Van de Wijer L, van der Heijden WA, Ter Horst R, Jaeger M, Trypsteen W, Rutsaert S, van Cranenbroek B, van Rijssen E, Joosten I, Joosten L, Vandekerckhove L, Schoofs T, van Lunzen J, Netea MG, Koenen HJPM, van der Ven AJAM, de Mast Q. The Architecture of Circulating Immune Cells Is Dysregu-lated in People Living With HIV on Long Term Antiretroviral Treatment and Relates With Markers of the HIV-1 Reservoir, Cytomegalovirus, and Microbial Translocation. Front Immunol. 2021 Apr 19;12:661990. doi: 10.3389/fimmu.2021.661990. eCollection 2021. PMID: 33953724 Free PMC ar-ticle.

van der Heijden WA, Wan J, Van de Wijer L, Jaeger M, Netea MG, van der Ven AJ, de Groot PG, Roest M, de Mast Q. Plasmatic Coagulation Capacity Correlates With Inflammation and Abacavir Use Dur-ing Chronic HIV Infection. J Acquir Immune Defic Syndr. 2021 May 1;87(1):711-719. doi: 10.1097/QAI.0000000000002633. PMID: 33492017

van der Heijden WA, Van de Wijer L, Keramati F, Trypsteen W, Rutsaert S, Horst RT, Jaeger M, Koenen HJ, Stunnenberg HG, Joosten I, Verweij PE, van Lunzen J, Dinarello CA, Joosten LA, Vandekerckhove L, Netea MG, van der Ven AJ, de Mast Q. Chronic HIV infection induces transcriptional and func-tional reprogramming of innate immune cells. JCI Insight. 2021 Apr 8;6(7):e145928. doi: 10.1172/jci.insight.145928. PMID: 33630761 Free PMC article.

van der Heijden WA, van de Wijer L, Jaeger M, Grintjes K, Netea MG, Urbanus RT, van Crevel R, van den Heuvel LP, Brink M, Rodenburg RJ, de Groot PG, van der Ven AJ, de Mast Q. Long-term treated HIV infection is associated with platelet mitochondrial dysfunction. Sci Rep. 2021 Mar 18;11(1):6246. doi: 10.1038/s41598-021-85775-5. PMID: 33739024 Free PMC article.

van der Heijden WA, van Deuren RC, van de Wijer L, van den Munckhof ICL, Steehouwer M, Riksen NP, Netea MG, de Mast Q, Vandekerckhove L, de Voer RM, van der Ven AJ, Hoischen A. Clonal hemat-opoiesis is associated with low CD4 nadir and increased residual HIV transcriptional activity in vi-rally suppressed individuals with HIV. J Infect Dis. 2021 Aug 21:jiab419. doi: 10.1093/infdis/jiab419. Online ahead of print. PMID: 34417800

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van der Vossen EWJ, Bastos D, Stols-Gonçalves D, de Goffau MC, Davids M, Pereira JPB, Li Yim AYF, Henne-man P, Netea MG, de Vos WM, de Jonge W, Groen AK, Nieuwdorp M, Levin E. Effects of fecal micro-biota transplant on DNA methylation in subjects with metabolic syndrome. Gut Microbes. 2021 Jan-Dec;13(1):1993513. doi: 10.1080/19490976.2021.1993513. PMID: 34747338

van der Zande HJP, Nitsche D, Schlautmann L, Guigas B, Burgdorf S. The Mannose Receptor: From Endocytic Receptor and Biomarker to Regulator of (Meta)Inflammation. Front Immunol. 2021 Oct 14;12:765034. doi: 10.3389/fimmu.2021.765034. eCollection 2021. PMID: 34721436 Free PMC ar-ticle. Review.

van Deuren RC, Arts P, Cavalli G, Jaeger M, Steehouwer M, van de Vorst M, Gilissen C, Joosten LAB, Din-arello CA, Mhlanga MM, Kumar V, Netea MG, van de Veerdonk FL, Hoischen A. Impact of rare and common genetic variation in the interleukin-1 pathway on human cytokine responses. Genome Med. 2021 May 25;13(1):94. doi: 10.1186/s13073-021-00907-w. PMID: 34034819 Free PMC article.

van Laarhoven A, Kurver L, Overheul GJ, Kooistra EJ, Abdo WF, van Crevel R, Duivenvoorden R, Kox M, Ten Oever J, Schouten J, van de Veerdonk FL, van der Hoeven H, Rahamat-Langendoen J, van Rij RP, Pickkers P, Netea MG. Interferon gamma immunotherapy in five critically ill COVID-19 patients with impaired cellular immunity: A case series. Med (N Y). 2021 Oct 8;2(10):1163-1170.e2. doi: 10.1016/j.medj.2021.09.003. Epub 2021 Sep 21. PMID: 34568856 Free PMC article.

van Leent MMT, Meerwaldt AE, Berchouchi A, Toner YC, Burnett ME, Klein ED, Verschuur AVD, Nauta SA, Munitz J, Prévot G, van Leeuwen EM, Ordikhani F, Mourits VP, Calcagno C, Robson PM, Soultanidis G, Reiner T, Joosten RRM, Friedrich H, Madsen JC, Kluza E, van der Meel R, Joosten LAB, Netea MG, Ochando J, Fayad ZA, Pérez-Medina C, Mulder WJM, Teunissen AJP. A modular approach toward producing nanotherapeutics targeting the innate immune system. Sci Adv. 2021 Mar 5;7(10):eabe7853. doi: 10.1126/sciadv.abe7853. Print 2021 Mar. PMID: 33674313 Free PMC article.

van Leent MMT, Beldman TJ, Toner YC, Lameijer MA, Rother N, Bekkering S, Teunissen AJP, Zhou X, van der Meel R, Malkus J, Nauta SA, Klein ED, Fay F, Sanchez-Gaytan BL, Pérez-Medina C, Kluza E, Ye YX, Wo-jtkiewicz G, Fisher EA, Swirski FK, Nahrendorf M, Zhang B, Li Y, Zhang B, Joosten LAB, Pasterkamp G, Boltjes A, Fayad ZA, Lutgens E, Netea MG, Riksen NP, Mulder WJM, Duivenvoorden R. Prosapo-sin mediates inflammation in atherosclerosis. Sci Transl Med. 2021 Mar 10;13(584):eabe1433. doi: 10.1126/scitranslmed.abe1433. PMID: 33692130

Vierock J, Rodriguez-Rozada S, Dieter A, Pieper F, Sims R, Tenedini F, Bergs ACF, Bendifallah I, Zhou F, Zeitzschel N, Ahlbeck J, Augustin S, Sauter K, Papagiakoumou E, Gottschalk A, Soba P, Emiliani V, Engel AK, Hegemann P, Wiegert JS. BiPOLES is an optogenetic tool developed for bidirectional dual-color control of neurons. Nat Commun. 2021 Jul 26;12(1):4527. doi: 10.1038/s41467-021-24759-5. PMID: 34312384

Vogt M. Using deep neural networks to explore chemical space. Expert Opin Drug Discov. 2021 Dec 29:1-8. doi: 10.1080/17460441.2022.2019704. Online ahead of print. PMID: 34918594

Wang D, Doestzada M, Chen L, Andreu-Sánchez S, van den Munckhof ICL, Augustijn HE, Koehorst M, Ruiz-Moreno AJ, Bloks VW, Riksen NP, Rutten JHW, Joosten LAB, Netea MG, Wijmenga C, Zherna-kova A, Kuipers F, Fu J. Characterization of gut microbial structural variations as determinants of human bile acid metabolism. Cell Host Microbe. 2021 Dec 8;29(12):1802-1814.e5. doi: 10.1016/j.chom.2021.11.003. Epub 2021 Nov 29. PMID: 34847370

Wang M, Yang Y, Cansever D, Wang Y, Kantores C, Messiaen S, Moison D, Livera G, Chakarov S, Wein-berger T, Stremmel C, Fijak M, Klein B, Pleuger C, Lian Z, Ma W, Liu Q, Klee K, Händler K, Ulas T, Schlitzer A, Schultze JL, Becher B, Greter M, Liu Z, Ginhoux F, Epelman S, Schulz C, Meinhardt A, Bhushan S. Two populations of self-maintaining monocyte-independent macrophages exist in adult epididymis and testis. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2013686117. doi: 10.1073/pnas.2013686117. PMID: 33372158

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Wan J, Vadaq N, Konings J, Jaeger M, Kumar V, de Laat B, Joosten L, Netea MG, van der Ven AJ, de Groot PG, de Mast Q, Roest M. Kallikrein augments the anticoagulant function of the protein C system in thrombin generation. J Thromb Haemost. 2022 Jan;20(1):48-57. doi: 10.1111/jth.15530. Epub 2021 Sep 28. PMID: 34532976

Warnat-Herresthal S, Schultze H, Shastry KL, Manamohan S, Mukherjee S, Garg V, Sarveswara R, Hän-dler K, Pickkers P, Aziz NA, Ktena S, Tran F, Bitzer M, Ossowski S, Casadei N, Herr C, Petersheim D, Behrends U, Kern F, Fehlmann T, Schommers P, Lehmann C, Augustin M, Rybniker J, Altmüller J, Mishra N, Bernardes JP, Krämer B, Bonaguro L, Schulte-Schrepping J, De Domenico E, Siever C, Kraut M, Desai M, Monnet B, Saridaki M, Siegel CM, Drews A, Nuesch-Germano M, Theis H, Heyck-endorf J, Schreiber S, Kim-Hellmuth S; COVID-19 Aachen Study (COVAS), Nattermann J, Skowasch D, Kurth I, Keller A, Bals R, Nürnberg P, Rieß O, Rosenstiel P, Netea MG, Theis F, Mukherjee S, Backes M, Aschenbrenner AC, Ulas T; Deutsche COVID-19 Omics Initiative (DeCOI), Breteler MMB, Giamarel-los-Bourboulis EJ, Kox M, Becker M, Cheran S, Woodacre MS, Goh EL, Schultze JL. Swarm Learning for decentralized and confidential clinical machine learning. Nature. 2021 Jun;594(7862):265-270. doi: 10.1038/s41586-021-03583-3. Epub 2021 May 26. PMID: 34040261 Free PMC article.

Wendisch D, Dietrich O, Mari T, von Stillfried S, Ibarra IL, Mittermaier M, Mache C, Chua RL, Knoll R, Timm S, Brumhard S, Krammer T, Zauber H, Hiller AL, Pascual-Reguant A, Mothes R, Bülow RD, Schulze J, Leipold AM, Djudjaj S, Erhard F, Geffers R, Pott F, Kazmierski J, Radke J, Pergantis P, Baßler K, Conrad C, Aschenbrenner AC, Sawitzki B, Landthaler M, Wyler E, Horst D; Deutsche COVID-19 OMICS Initiative (DeCOI), Hippenstiel S, Hocke A, Heppner FL, Uhrig A, Garcia C, Machleidt F, Her-old S, Elezkurtaj S, Thibeault C, Witzenrath M, Cochain C, Suttorp N, Drosten C, Goffinet C, Kurth F, Schultze JL, Radbruch H, Ochs M, Eils R, Müller-Redetzky H, Hauser AE, Luecken MD, Theis FJ, Con-rad C, Wolff T, Boor P, Selbach M, Saliba AE, Sander LE. SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis. Cell. 2021 Dec 22;184(26):6243-6261.e27. doi: 10.1016/j.cell.2021.11.033. Epub 2021 Nov 27. PMID: 34914922 Free PMC article.

Willenborg S, Sanin DE, Jais A, Ding X, Ulas T, Nüchel J, Popović M, MacVicar T, Langer T, Schultze JL, Gerbaulet A, Roers A, Pearce EJ, Brüning JC, Trifunovic A, Eming SA.Mitochondrial metabolism co-ordinates stage-specific repair processes in macrophages during wound healing. Cell Metab. 2021 Dec 7;33(12):2398-2414.e9. doi: 10.1016/j.cmet.2021.10.004. Epub 2021 Oct 28. PMID: 34715039

Wolters TLC, van der Heijden CDCC, Pinzariu O, Hijmans-Kersten BTP, Jacobs C, Kaffa C, Hoischen A, Netea MG, Smit JWA, Thijssen DHJ, Georgescu CE, Riksen NP, Netea-Maier RT. The association between treatment and systemic inflammation in acromegaly. Growth Horm IGF Res. 2021 Apr-Jun;57-58:101391. doi: 10.1016/j.ghir.2021.101391. Epub 2021 Apr 30. PMID: 33964727 76. He-patic synthesis of triacylglycerols containing medium-chain fatty acids is dominated by diacylg-lycerol acyltransferase 1 and efficiently inhibited by etomoxir. Wunderling K, Leopold C, Jamitzky I, Yaghmour M, Zink F, Kratky D, Thiele C. Mol Metab. 2021 Mar;45:101150. doi: 10.1016/j.mol-met.2020.101150. Epub 2020 Dec 23. PMID: 33359403

Wunderling K, Leopold C, Jamitzky I, Yaghmour M, Zink F, Kratky D, Thiele C. Hepatic synthesis of triacylglycerols containing medium-chain fatty acids is dominated by diacylglycerol acyltrans-ferase 1 and efficiently inhibited by etomoxir. Mol Metab. 2021 Mar;45:101150. doi: 10.1016/j.mol-met.2020.101150. Epub 2020 Dec 23. PMID: 33359403

Xu CJ, Gruzieva O, Qi C, Esplugues A, Gehring U, Bergström A, Mason D, Chatzi L, Porta D, Lodrup Carlsen KC, Baïz N, Madore AM, Alenius H, van Rijkom B, Jankipersadsing SA, van der Vlies P, Kull I, van Hage M, Bustamante M, Lertxundi A, Torrent M, Santorelli G, Fantini MP, Hovland V, Pesce G; BIOS Consortium, Fyhrquist N, Laatikainen T, Nawijn MC, Li Y, Wijmenga C, Netea MG, Bousquet J, Anto JM, Laprise C, Haahtela T, Annesi-Maesano I, Carlsen KH, Gori D, Kogevinas M, Wright J, Söderhäll C, Vonk JM, Sunyer J, Melén E, Koppelman GH. Shared DNA methylation signatures in childhood allergy: The MeDALL study. J Allergy Clin Immunol. 2021 Mar;147(3):1031-1040. doi: 10.1016/j.jaci.2020.11.044. Epub 2020 Dec 15. PMID: 33338541

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Yaghmour MH, Thiele C, Kuerschner L. An advanced method for propargylcholine phospholipid detection by direct-infusion mass spectrometry. J Lipid Res. 2021 Jan 13:100022. doi: 10.1016/j.jlr.2021.100022. Online ahead of print. PMID: 33453218

Yoshimori A, Hu H, Bajorath J. Adapting the DeepSARM approach for dual-target ligand design. J Com-put Aided Mol Des. 2021 May;35(5):587-600. doi: 10.1007/s10822-021-00379-5. Epub 2021 Mar 13. PMID: 33712972

Yudi Utomo R, Asawa Y, Okada S, Ban HS, Yoshimori A, Bajorath J, Nakamura H. Development of cur-cumin-based amyloid β aggregation inhibitors for Alzheimer’s disease using the SAR matrix ap-proach. Bioorg Med Chem. 2021 Aug 8;46:116357. doi: 10.1016/j.bmc.2021.116357. Online ahead of print. PMID: 34391121

Yu Z, Centola M, Valero J, Matthies M, Šulc P, Famulok M. A Self-Regulating DNA Rotaxane Linear Actu-ator Driven by Chemical Energy. J Am Chem Soc. 2021 Aug 25;143(33):13292-13298. doi: 10.1021/jacs.1c06226. Epub 2021 Aug 16. PMID: 34398597