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PERBEDAAN TROMBOSIT SEBELUM DAN SESUDAH

TRANSFUSI FRESH FROZEN PLASMA PADA

PENDERITA DEMAM BERDARAH DENGUE

Menik Hastutik1, Tulus Ariyadi2, Harun Nurrachmat3

1. Program Studi D IV Analis Kesehatan Fakultas Ilmu Keperawatan dan Kesehatan

Universitas Muhammadiyah Semarang.

2. Laboratorium Patologi Klinik Fakultas Ilmu Keperawatan dan Kesehatan Universitas

Muhammadiyah Semarang.

3. Laboratorium Patologi Klinik RSU Tugurejo Semarang.

ABSTRAK

Trombositopenia berat sering terjadi pada fase akut DBD dan menjadi dilema dalam

menangani pasien karena kekhawatiran terjadi perdarahan. Transfusi darah yang biasa

diberikan dalam penanganan kasus tersebut adalah transfusi suspensi plasma beku atau

Fresh Frozen Plasma (FFP) yang mengandung plasma dan faktor koagulasi labil (faktor

V dan faktor VIII). Setiap unit biasanya dapat menaikkan masing-masing kadar faktor

pembekuan sebesar 2-3% pada orang dewasa, dosis inisial adalah 10-15 ml/kg. Transfusi

plasma diharapkan meningkatkan trombosit karena fungsi plasma tersebut untuk

menambal atau menutup perembesan atau kebocoran pada penderita DBD. Pemeriksaan

jumlah trombosit dilakukan 6 jam setelah pasien selesai transfusi darah FFP. Tujuan

penelitian untuk mengetahui perbedaan jumlah trombosit sebelum dan sesudah transfusi

jenis Fresh Frozen Plasma pada penderita DBD. Jenis penelitian analitik pendekatan

cross sectional. Penelitian dilaksanakan di RSUD Tugurejo pada bulan Juni-Juli 2017

terhadap 16 pasien rawat inap diagnosis DBD dengan menghitung jumlah trombosit

sebelum dan sesudah dilakukan transfuse FFP. Hasil diperoleh variasi peningkatan

jumlah trombosit sesudah transfusi FFP, yang meningkat dibanding sebelum transfusi

FFP. Peningkatan bervariasi, antara 3,13%-75% atau rata-rata 28,32%. Uji beda Paired t

Test diperoleh hasil terdapat perbedaan bermakna antara jumlah trombosit sebelum dan

sesudah FFP.

Kata kunci : jumlah trombosit, DBD, fresh fozen plasma

repository.unimus.ac.id

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THE DIFFERENCE OF THROMBOCYTE BEFORE AND AFTER

FRESH FROZEN PLASMA TRANSFUSION ON

DENGUE HAEMORAGIC FEVER PATIENTS

Menik Hastutik1, Tulus Ariyadi2, Harun Nurrachmat3

1. StudyProgram of D IV Health Analyst Faculty of Nursing and Health University of

Muhammadiyah Semarang.

2. Laboratory of Clinic PathologyFaculty of Nursing and Health Sciences University of

Muhammadiyah Semarang.

3. Laboratory of Clinic PathologyRSU Tugurejo Semarang.

ABSTRACT

Severe thrombocytopenia often occurs on the DHF acute phase and becomes a dilemma

in dealing with patients because of worries about bleeding. The usual blood transfusion is

given in that case treatment are frozen plasma suspension transfusion or Fresh Frozen

Plasma (FFP) which is containing plasma and unstable coagulation factors (factor V and

factor VIII). Each unit usually can raise each freezing factor level by 2-3% on adults, the

initial dose is 10-15 ml / kg. Plasma transfusion is expected to increase thrombocyte

because that plasma function is to patch or close the infiltration or leakage on DHF

patients. The examination of thrombocyte amount was performed 6 hours after the

patients completed FFP blood transfusion. The research goal is to know the difference of

thrombocyte amount before and after Fresh Frozen Plasma type transfusion on DHF

patients. The research type is cross sectional approach analytic. The research was

conducted in RSUD Tugurejo on June-July 2017 of 16 towards hospitalized patients who

were DHF diagnosed by counting thrombocyte amount before and after FFP transfusion.

The result obtained variation of thrombocyte amount increase after FFP transfusion,

which is increased compared to before the FFP transfusion. The increase varies, between

3.13% -75% or average 28.32%. Different test of Paired t Test was obtained result that

there was significant difference between thrombocyte amount before and after FFP.

Keywords: thrombocyte amount, DHF, fresh fozen plasma

repository.unimus.ac.id