Peran Flora Normal

8/19/2019 Peran Flora Normal

1/16


2/16

Penge!"#n Flo# Nom# T$%$&

M#n$'"# (M"ko%"o!#)

* Flo# nom#l #+#l#& k$mp$l#n

m"koog#n"'me y#ng 'e,## #l#m" !e+#p#!

p#+# !$%$& m#n$'"# nom#l +#n 'e!.

Ke%#ny#k#n -lo# nom#l y#ng !e+#p#!

p#+# ! $%$& m#n$'"# #+#l#& +#" en"'

%#k!e". N#m$n %e%e#p# /"$'0 #m$0 +#npo!o1o# $g# +#p#! +"!em$k#n p#+# o#ng

'e!.


3/16

M"ko%"o!# nom#l !$%$& m#n$'"# y#ng 'e!

pel$ +"ke!#&$" k#en# #l#'#n #l#'#n

%e"k$!3

D"ke!#&$"ny# l "n" +#p#! mem%#n!$ men+$g# m#,#m

"n-ek'" y#ng m$ngk"n !"m%$l 'e!el#& !e#+"ny#

ke$'#k#n #"ng#n p#+# '"!$' '"!$' y#ng k&$'$'.

H#l "n" mem%e"k#n pe!$n$k mengen#" kem$ngk"n#n

'$m%e +#n pen!"ngny# m"koog#n"'me y#ng !e#m#!"

p#+# %e%e#p# "n-ek'" kl"n"'.

H#l "n" +#p#! mem%$#! k"!# men#$& pe!"#n le% "&

%e'# !e+#p "n-ek'" y#ng +"'e%#%k#n ole&

m"koog#n"'me y#ng me$p#k#n m"ko%"o!# nom#l

#!#$ #'l" p#+# "n#ng m#n$'"#


4/16

A'#l M$l# M"ko%"o!# M#n$'"#

* P#+# ke#+##n #l#m"#&0 #n"n m#n$'"# m$l# m$l#

mempeole& m"koog#n"'me ke!"k# le4#!

'ep#n#ng '#l$#n l#&". 5#'#+ #'#+ en"k "!$+"peole&ny# mel#l$" kon!#k pem$k##n0 penel#n#n

#!#$ peng&"'#p#n. M"ko%#m"ko%# "n" 'ege#

+"'e!#" ole& m"ko%em"ko%e l#"n +#" %#ny#k

'$m%e y#ng l#ng'$ng %e#+# +" 'ekel"l"ng %#y"

y#ng %#$ l#&" !e'e%$!.


5/16

Ne6!..

* M"koog#n"'me y#ng menem$k#n l"ngk$ng#n y#ng 'e'$#"0

p#+# pem$k##n l$# #!#$ +#l#m !$%$&0 +eng#n ,ep#!

%e%"#k +#n mene!#p. 5#+" +" +#l#m 4#k!$ %e%e#p# #m

'e!el#& l#&"0 %#y" mempeole& -lo# m"ko%A y#ng #k#n

men#+" m"ko%"o!# y#ng #'l". Se!"#p %#g"#n !$%$& m#n$'"#0

+eng#n kon+"'" l"ng k$ng#n y#ng k&$'$'0 +"&$n" %e%#g#"m#,#m m"koog#n"'me !e!en!$. Se%#g#" ,on!o&0 +" ongg#

m$l$! %ekem%#ng pop$l#'" m"ko%e #l#m"#& y#ng %e%e+#

+eng#n y#ng #+# +" $'$'. D#l#m 4#k!$ '"ngk#!0 %eg#n!$ng

kep#+# -#k!o-#k!o 'epe!" %e#p# 'e"ngny# +"%e'"&k#n0

n$!"'"ny#0 pene#p#n p"n'"p p"n'"p ke'e!#n0 'e!#kon+"'" &"+$p0 m#k# #n#k !e'e%$! #k#n memp$ny#"

m"ko%"o!# nom#l y#ng m#,#mny# '#m# 'epe!" y#ng #+#

p#+# o#ng +e4#'#.


6/16

7#m%# 83 In" me$p#k#n %$k!" %#&4#

'#mp#" 4#k!$ +"l#&"k#n0 #n"n !"+#k

meng#n+$ng m"koog#n"'me.


7/16

Penggolong#n Flo# Nom#l T$%$& M#n$'"#

* Flo# nom#l !$%$& m#n$'"# %e+#'#k#n %en!$k+#n '"-#! ke+"#nny# +#p#! +"golongk#n men#+"

2 en"'0 y#"!$3

8. M"koog#n"'me !e!#p9nom#l (e'"+en!

-lo#9"n+"geno$')3 y#"!$ m"koog#n"'me en"'!e!en!$ y#ng %"#'#ny# +"!em$k#n p#+# %#g"#n

!$%$& !e!en!$ +#n p#+# $'"# !e!en!$.

2. M"koog#n"'me 'emen!## (!#n'"en! -lo#)3 y#"!$

m"koog#n"'me nonp#!ogen #!#$ po!en'"#lp#!ogen y#ng %e#+# +" k$l"! +#n 'el#p$!

len+"9m$ko'# 'el#m# k$$n 4#k!$ %e%e#p# #m0

"0 #!#$ m"ngg$.


8/16

Pe#n Flo# Nom#l T$%$&

M#n$'"#Flo# y#ng mene!#p +"'el#p$! len+" (m$ko'#) +#n

k$l"! +#p#! men,eg#& kolon"#l"'#'" ole& %#k!e"p#!ogen +#n men,eg#& peny#k"! #k"%#! g#ngg$#n

%#k!e". Mek#n"'me g#ngg$#n "n" !"+#k el#'.

M$ngk"n mel#l$" kompe!"'" p#+# e'ep!o #!#$

!emp#! peng"k#!#n p#+# 'el pen#m$0 kompe!"'"$n!$k 1#! m#k#n#n0 pengm%#!#n ole& po+$k

me!#%ol"k #!#$ #,$n0 pengm%#!#n ole& 1#!

#n!"%"o!"k #!#$ %#k!e"o'"n (%#,!e"o,"n'). S$pe'"

-lo# nom#l #k#n men"m%$lk#n !emp#! ko'ong

y#ng ,en+e$ng #k#n +"!emp#!" ole&

m"koog#n"'me +#" l"ngk$ng#n #!#$ !emp#! l#"n

p#+# !$%$&. Be%e#p# %#k!e" %e'"-#! opo!$n"'

+#n %"'# men#+" p#!ogen.


9/16

Ne6!..

* Te!#p" y#ng pen!"ng #+#l#& -lo# nom#l !"+#k

%e%#y# +#n +#p#! %em#n-##! %#g" !$%$& "n#ng

p#+# !emp#! y#ng 'e$'ny# #!#$ !"+#k #+#

kel#"n#n y#ng menye!#"ny#. Meek# +#p#!

men"m%$lk#n peny#k"! "k# %e#+# p#+# lok#'"

y#ng #'"ng +#l#m $ml#& %#ny#k +#n "k# !e+#p#!

-#k!o-#k!o pe+"'po'"'". (5#4e!10 Meln",k0 +#n

A+el%eg'0M"ko%"olog" Ke+ok!e#n(Me+",#lM",o%"ology)02::;3 2


10/16

Penyebaran dan Terjadinya Mikrobiota

Manusia.* K$l"! %e'"-#! 'e+"k"! #'#m +eng#n pH ; ? +#n mem"l"k"

!empe#!$ k$#ng +#" @


11/16

Ne6!C

* Pel"n+$ng l#"n !e+#p kolon"#l"'#'" k$l"! ole& %#k!e"p#!ogen #+#l#& m"ko-lo# nom#l k$l"!. M"ko-lo#

!e'e%$! me$p#k#n '$#!$ k$mp$l#n +#" %#k!e"

nonp#!ogen y#ng nom#l %ekolon"'#'" p#+# 'e!"#p #e#

k$l"! y#ng m#mp$ men+$k$ng pe!$m%$n %#k!e".

B#k!e" p#!ogen y#ng #k#n meng"n-ek'" k$l"! $'m#mp$ %e'#"ng +eng#n m"ko-lo# nom#l y#ng #+#

$n!$k men+#p#!k#n !emp#! kolon"'#'" 'e!# n$!"en

$n!$k !$m%$& +#n %ekem%#ng. M"ko-lo# nom#l k$l"!

!e$!#m# !e+"" +#" %#k!e" g#m po'"!"-. Te!#p" %#k!e"

g#m neg#!"- 'epe!" E',&e",&"# ,ol" y#ng %"!#!ny#

#+# +" +#l#m $'$' m#n$'"#0 $g# %"'# !e+#p#! p#+#

k$l"! m#n$'"# k#en# #+#ny# kon!#m"n#'" ko!o#n


12/16

Ne6!..

•#l#$p$n #+# pe!#n#n !e'e%$! +" #!#'0%e%e#p# %#k!e" p#!ogen +#p#! %ekolon"'#'"

'emen!## p#+# k$l"! +#n +#p#! meng#m%"l

m#n-##! +#" l$k# y#ng #+# p#+# pem$k##n k$l"!

$n!$k mempeole& #l#n m#'$k ke #"ng#n y#ng

#+# +" %#4#& k$l"!. D" %#4#& k$l"!0 meek# #k#n

meng+#p" 'e$ml#& 'el y#ng !el#& !e'pe'"-"k#'"

y#ng +"'e%$! +eng#n 'k"n #''o,"#!e+ lymp&o"+

!"''$e (SALT). F$ng'" SALT #+#l#& men,eg#&

%#k!e" p#!ogen !"+#k '#mp#" ke #e# y#ng le%"& #$& +" %#4#& k$l"! +#n men,eg#& meek# !"+#k

'#mp#" ke #l"#n +##&. Rel#!"- 'e+"k"! y#ng

+"ke!#&$" !en!#ng 'el 'el y#ng meny$'$n SALT.


13/16

Ne6!..

* S#l#& '#!$ !"pe 'elny# #+#l#& 'el y#ngmem#p#k#n #n!"gen y#ng !e'pe'"#l"'#'" y#ng

mem%#n!$ !"pe 'el y#ng l#"n0 'pe,"#l"1e+ 'k"n

'eek"ng lymp&o,y!e0 $n!$k mempo+$k'" #n!"%o+".

Sel 'el l"m-o'"! !e'e%$! $g# mempo+$k'" '"!ok"n0

po!e"n y#ng me#ng'#ng 'el 'el +#" '"'!em "m$n

+#n mem"l"k" 'e$ml#& e-ek l#"n. Komponen SALT

y#ng l#"n #+#l#& ke#!"no'"! y#ng %#ny#k !e+#p#!

p#+# l#p"'#n ep"+em"' +#n %e!#ngg$ng #4#%

$n!$k memel"# l"ngk$ng#n m"kok$l"! y#ng%e'"-#! #'#m. Ke#!"no'"! mempo+$k'" '"!ok"n

+#n $g# m#mp$ $n!$k "nge'!" +#n mem%$n$&

%#k!e".


14/16

NET..

* F#k!o-#k!o y#ng %epe#n meng&"l#ngk#n -lo#

'emen!## p#+# k$l"! #+#l#& pH en+#&0 #'#m lem#kp#+# 'eke'" 'e%#'e# +#n #+#ny# l"'o1"m. Beke"ng#!

y#ng %ele%"n #!#$ pen,$,"#n +#n m#n+" !"+#k

meng&"l#ngk#n #!#$ meng$%#& 'e,## '"gn"-"k#n -lo#

!e!#p. 5$ml#& m"koog#n"'me pem$k##n m$ngk"n

%ek$#ng +eng#n menggo'ok 'e,## k$#! 'e!"#p "

+eng#n '#%$n y#ng meng#n+$ng &ek'#klo-oen #!#$

+e'"n-ek!#n l#"n0 n#m$n -lo# 'e,## ,ep#! m$n,$l

kem%#l" +#" kelen# 'e%#'e# +#n ke"ng#!0 me'k"p$n

!"+#k #+# &$%$ng#n 'e,## !o!#l !e+#p k$l"! %#g"#nl#"n m#$p$n l"ngk$ng#n. Pengg$n##n !$!$p #p#! p#+#

k$l"! ,en+e$ng menye%#%k#n pop$l#'" m"ko%"o!#

'e,## ke'el$$n '#ng#! men"ngk#! +#n +#p#!

men"m%$lk#n pe$%#n k$#l"!#!"- -lo# k$l"!.


15/16


16/16

SELESAI

TERIMA KASIH

Peran Flora Normal

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