20081128-Jkt-04-Bagaimana Menggunakan Propolis Sebagai Obat

7/30/2019 20081128-Jkt-04-Bagaimana Menggunakan Propolis Sebagai Obat

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Bagaimana menggunakan

propolis sebagai obat

Aznan Lelo

Dep. Farmakologi & Terapeutik,Fakultas Kedokteran

Universitas Sumatera Utara28 November 2008 MEDCON HD meetin Jakarta


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Lem Lebah (Propolis)

getah (resin) berbau manis dari pepohonanyang dikumpulkan lebah, lalu dikunyahnya

dan menaruhnya dalam keranjang serbukyang ada pada kaki belakangnya

Dengan kata lain lem sarang lebah yang

terbuat dari resin tanamanUntuk menghangatkan sarang lebah dan

terjauh dari kuman-kuman

Berhasiat sebagai antimikrobaUntuk penyembuhan berbagai penyakit,

bagian dari apitherapy.


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Lem Lebah (Propolis)

Komposisi sangat bervariasi, bergantung darijenis tanaman yang didatangi lebah

o 50-55% getah & balsam,o 25-35% lilin lebah,o 10-15% minyak alami,

o 5% serbuk lebah dano 5% bahan organik lain dan mineral.

Kandungan kimiawi utamanyao Caffeic acid phenethyl ether orCAPE.o Phenolicso Terpeneso Hydrocarbons

oAcidso Bioflavonoids


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Interesting Properties of CAPE

Inhibits Nuclear Transcription Factor

KappaB or NF-B, which drives T-cellproliferation and effector functions.

Anti-inflammatory activity. Treats arthritis and inflammatory bowel

disease, or IBD. Inhibits IL-2 which also drives T-cell

proliferation.


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Khasiat Farmakologi PropolisMerangsang pembentukan antibodi.

Menghambat masuknya virus ke dalam CD4

lymphocytes, terutama HIV-1.Meningkatkan khasiat anti-virus, zidovudine.

Menanggulangi infeksi opportunistic pasien AIDS

Meningkatkan produksi IFN- dan aktivitas

macrophages.o anti-bakteri

o anti-inflamasi

o anti-tumor

o hepato-protective

o anti-oksidan

o anti-allergi


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Compounds responsible for the biological activity of

different propolis types

Propolis

type

Anti-

bacterial

Anti-inflam-

matory

Anti-

tumor

Hepato-

protective

Anti-

oxidant

Anti-

allergenic

European

(poplar

type)

Flavanones,flavones,

phenolic

acids and

their esters

Flavanones,flavones,

phenolic

acids and

their esters

Caffeic acid

phenethyl

ester

Caffeic acid,ferulic acids

acid, caffeic

acid their

esters

Flavonoids,phenolic

and their

esters

3,3-

Dimethyl-

allyl caffeate

Brazilian

(Baccharis

type)

Prenylated

p-coumaric

acis,

labdane

diterpenes

Unidentified

Prenylatedp-coumaric

acids,

clerodane

diterpenes,

benzofurane

Prenylated

p-coumaric

acis,

flavonoids,

lignans,

caffeoyl

quinic acids

Prenylated

p-coumaric

acis,

flavonoids

Not tested

Cuban

Prenylated

benzopheno

nes

Not tested

Prenylated

benzopheno

nes

Unidentified

Prenylated

benzopheno

nes

Not tested

Taiwanese Not tested Not tested Prenylatedflavanones

Not tested Prenylatedflavanones

Not tested

Evid Based Complement Alternat Med. 2(1):2932,2005
http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=41487http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=41487


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Total Polyphenol Content (mgGAE/g)

0 4 8 12 16

Peach

Red Grape

Red D Apple

Yellow Pear

Green Pear

Granny S Apple

Black Plum

Raspberry

Blackberry

Raisin

Cranberries

HD Bee Pollen

Peach Red Grape Red D Apple Yellow Pear Green Pear Granny S Apple

Black Plum Raspberry Blackberry Raisin Cranberries HD Bee Pollen

evidence base produkperlebahan High Desert


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ORAC (Oxygen Radical Absorbance Capacity) Chart

whole food antioxidant activity


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Published Evidence of Bee Products

Imhof M, et al. Propolis solution for the treatment ofchronic vaginitis.

Int J Gynaecol Obstet. 89(2):127-32,2005.

University of Vienna, Austriao Propolis may have a role as an alternative treatment for chronic

vaginal infection. Botushanov PI, et al. A clinical study of a silicate

toothpaste with extract from propolis.

Folia Med (Plovdiv). 43(1-2):28-30,2001.Higher Medical Institute, Faculty of Dentistry, Bulgaria.o The toothpaste shows very good plaque-cleaning, plaque-

inhibiting and anti-inflammatory effect


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Idiopathic convulsion

Eka Puji Rahayu, pr, 6 tahun.

KU: kejang tiap 10 menit, sampai merot2.sudah berobat keberbagai dokter spesialis

anak dan syaraf. Temuan: microencephali, obese.

Terapi: madu dan propolis 2 x sehari. Sesudah 3 minggu:

Kejang 2 kali sehari dan tidak gelisah.


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Pemeriksaan Trombosit,Hemoglobin dan Hematokritsetiap hari selama 4hari

Pasien DBDdengan standar pengobatanDBDdan diberi propolis 4x1gram

Kontrol (Pasien DBDdenganstandar pengobatan RSUDr.Pirngadi)

Pemeriksaan Trombosit,Hemoglobin dan Hematokrit

Pasien Demam Berdarah DengueRumah Sakit UmumDr.Pirngadi

Alur Penelitian


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Bee Propolis:Ancient Cure for Todays Ailments

By: Dana Catalfamo


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Major Components

Caffeic acid phenethyl ether or

CAPE.

Phenolics

Terpenes

Hydrocarbons

Acids Flavonoids


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Increased Antibody Production

(Sforcin, Orsi, & Bankova, 2005)


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Inhibition of NF-B

CAPE inhibited NF-B binding to macrophages

and decreased cytokine production. Tumor necrosis factor alpha, TNF-, which

stimulates macrophages to kill tumor cells was

used to see if NF- B would bind. Anti-inflammatory activity.

Macrophages underwent apoptosis in patientswith IBD leading to healing of the injuries to the

colon.


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Inhibition of NF-B

(Fitzpatrick, Wang, & Le, 2001)


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CAPE Induces Apoptosis in

Macrophages in Patients with IBD



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CAPE Reduces Injury to the Colon



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Anti-viral Activity

Viral entry of HIV-1 was inhibited in CD4

lymphocytes.

Effectiveness of the reverse transcriptase

inhibitor, zidovudine, was increased.

Virus was kept from proliferating.

HUGE BREAKTHROUGH!!!!!


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Propolis Decreased Viral Expression

in CD4 Cells

(Gekker, Hu, Spivak, Lokensgard, & Peterson, 2005)


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Pharmacology

No recommended dose.

Capsules, liquid, lozenges, tablets,creams, gels, toothpastes, mouth rinses,

and cough syrups. Well tolerated unless a person is allergic

to a component of propolis.

If allergic, hives result.


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20081128-Jkt-04-Bagaimana Menggunakan Propolis Sebagai Obat

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