© Tine Norman Alver, 2020 Series of dissertations submitted to the Faculty of Medicine, University of Oslo ISBN 978-82-8377-651-5 All rights reserved. No part of this publication may be reproduced or transmitted, in any form or by any means, without permission. Cover: Hanne Baadsgaard Utigard. Print production: Reprosentralen, University of Oslo.

α

TAD TADbHLH-ZIP

S298S73 S397 S401 S405 S409S69

p90RSKGSK3 GSK3 GSK3GSK3GSK3 ERK

p300/CBP

N C

Y22 Y35 Y90

KITD816V

AKT

K316

PIAS3

K182

UBC9MITFE318K

K201

CaspaseD345

I

II

μ

μ

μ μ

μ