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Data Tablet Ramimprilat (Reference)

 Time (hr) Con (mg/l) time inte Averengen Conc (mg/l

0 0 0 0

0.01 1.13 0.01 0.00565

0.02 3.51 0.01 0.0232

0.04 7.23 0.02 0.1074

0.06 11.21 0.02 0.1844

0.08 13.11 0.02 0.2432

0.1 13.15 0.02 0.2626

0.12 14.03 0.02 0.2718

2.5 11.13 2.38 29.9404

3 11 0.5 5.5325

3.5 10.16 0.5 5.294 8.02 0.5 4.545

5 7.15 1 7.585

6 4.89 1 6.02

8 3.16 2 8.05

12 1.28 4 8.88

24 1.03 12 13.86

36 0.55 12 9.48

48 0.23 12 4.6872 0.15 24 4.56

109.52115

0.216

AUC 70! " 109.737

  0#693

AUC072

AUC 0-∞ AUC 0-72 ! AUC 72-∞

AUC 72! " C72 " 0.15 "

" 0.693

AUC 072 $ C %&hir "

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Data Tablet Ramimprilat (te#t)

Are% (mg'r/l) Time (hr) Con (mg/l) time int

0 0 0 0

0.00565 0.01 1.02 0.01

0.0232 0.02 2.11 0.01

0.1074 0.04 6.22 0.02

0.1844 0.06 9.01 0.02

0.2432 0.08 10.91 0.02

0.2626 0.1 12.35 0.02

0.2718 0.12 12.29 0.02

29.9404 2.5 11.51 2.38

5.5325 3 10.24 0.5

5.29 3.5 9.03 0.54.545 4 7.31 0.5

7.585 5 5.67 1

6.02 6 3.98 1

8.05 8 2 2

8.88 12 1.15 4

13.86 24 1 12

9.48 36 0.98 12

4.68 48 0.5 124.56 72 0.29 24

0.$2

AUC 70! " 110.7%

  0#693

AUC 072

AUC 0-∞ AUC 0-72 ! AUC 72-∞

AUC 72! " C72 " 0.29 "

" 0.693

AUC 072 $ C %&hir "

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Averengen Conc (mg/l) Are% (mg'r/l)

0

0.0051 0.0051

0.01565 0.01565

0.0833 0.0833

0.1523 0.1523

0.1992 0.1992

0.2326 0.2326

0.2464 0.2464

28.322 28.322

5.4375 5.4375

4.8175 4.81754.085 4.085

6.49 6.49

4.825 4.825

5.98 5.98

6.3 6.3

12.9 12.9

11.88 11.88

8.88 8.889.48 9.48

110.33155

&ra'

c+n#entrati+n pla#ma

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0 10 20 30 40 50 60 70 800

5

10

15

20

25

30

35

  ata tablet Ramiprilat (Te#t *# Reference)

Averengen Conc (mg/l)

Averengen Conc (mg/l)

time

  ,

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