Hematopeitic Agents

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Transcript of Hematopeitic Agents

Hematopoietic Agents

Problem-based Solving

Seorang ibu hamil 3 bulan datang ke praktek Anda dengan keluhan pening dan muntah. Os mengatakan bahwa pada kehamilan pertama ini, ia merasakan pening pertama sekali sebulan yang lalu. Pada pemeriksaan fisik TD 110/80 mmHg, tempaeratur 36,8˚C, frekuensi pernafasan 29x/menit, denyut nadi 90 x/menit. Pemeriksaan darah diperoleh Hb. 10.00 gr%.

1. Apa yang menyebabkanrasa pening pada ibu ini ? 2. Mengapa terjadi kekurangan pada Hb (10.00 gr%) pada ibu ini ? 3. Bagaimana cara penangannya ? 4. Apa saran Anda ?

Hematopoeisis and Hematopoietic Growth Factor

Ep, erytropeitin; G-CSF, Granulocyte colony-stimulating factor; GM-CSF, granulocyte-macrophage colony stimulating factor; IL, interleukin; SCF; stem cell factor; Tpo thrombopoeitin

Blood vessels and the blood cells

Causes of Anemia

Low Reticulocyte count (Hypoproliferative anemia) : Bone marrow is not making sufficient RBC

High Reticulocyte Count : Hemolytic anemia, increased destruction of RBC despite increased production

Iron Metabolism

Iron Absorption by Gastrointestinal Epithelial Cell

Structures of Folic Acid and Vitamine B12

Biochemical Reactions involving Folic Acid and Vitamine B12

The Role of Endogenous Hematopoietic Growth Factors in Blood Cell Differentiation

GM-CSF = glanulocyte macrophage-colony stimulating factor

SCF = Stem cell factor

Stimulation of Erythropoeitin (Epo) Synthesis by Hypoxia