Hematopeitic Agents

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Hematopoietic Agents

Transcript of Hematopeitic Agents

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Hematopoietic Agents

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Problem-based Solving

Seorang ibu hamil 3 bulan datang ke praktek Anda dengan keluhan pening dan muntah. Os mengatakan bahwa pada kehamilan pertama ini, ia merasakan pening pertama sekali sebulan yang lalu. Pada pemeriksaan fisik TD 110/80 mmHg, tempaeratur 36,8˚C, frekuensi pernafasan 29x/menit, denyut nadi 90 x/menit. Pemeriksaan darah diperoleh Hb. 10.00 gr%.

1. Apa yang menyebabkanrasa pening pada ibu ini ? 2. Mengapa terjadi kekurangan pada Hb (10.00 gr%) pada ibu ini ? 3. Bagaimana cara penangannya ? 4. Apa saran Anda ?

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Hematopoeisis and Hematopoietic Growth Factor

Ep, erytropeitin; G-CSF, Granulocyte colony-stimulating factor; GM-CSF, granulocyte-macrophage colony stimulating factor; IL, interleukin; SCF; stem cell factor; Tpo thrombopoeitin

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Blood vessels and the blood cells

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Causes of Anemia

Low Reticulocyte count (Hypoproliferative anemia) : Bone marrow is not making sufficient RBC

High Reticulocyte Count : Hemolytic anemia, increased destruction of RBC despite increased production

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Iron Metabolism

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Iron Absorption by Gastrointestinal Epithelial Cell

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Structures of Folic Acid and Vitamine B12

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Biochemical Reactions involving Folic Acid and Vitamine B12

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The Role of Endogenous Hematopoietic Growth Factors in Blood Cell Differentiation

GM-CSF = glanulocyte macrophage-colony stimulating factor

SCF = Stem cell factor

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Stimulation of Erythropoeitin (Epo) Synthesis by Hypoxia